psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V39	R:R:W38	14.71	No	No	0	4	3
2	R:R:G288	R:R:W38	2.81	No	No	0	3	3
3	R:R:V291	R:R:V39	4.81	No	No	0	4	4
4	R:R:L295	R:R:L43	4.15	Yes	No	0	5	5
5	R:R:L47	R:R:T51	2.95	Yes	No	1	6	5
6	R:R:L47	R:R:Y94	17.58	Yes	Yes	1	6	7
7	R:R:I97	R:R:L47	2.85	No	Yes	0	5	6
8	R:R:L47	R:R:L98	2.77	Yes	No	0	6	6
9	R:R:I48	R:R:L98	4.28	No	No	0	4	6
10	R:R:C302	R:R:T50	8.45	No	No	0	7	7
11	R:R:T51	R:R:Y94	7.49	No	Yes	1	5	7
12	R:R:D54	R:R:N58	9.42	No	Yes	0	8	9
13	R:R:D54	R:R:D86	6.65	No	Yes	0	8	9
14	R:R:L59	R:R:V55	2.98	No	No	4	5	5
15	R:R:L87	R:R:V55	5.96	Yes	No	4	7	5
16	R:R:A83	R:R:N58	4.69	No	Yes	0	9	9
17	R:R:L87	R:R:N58	6.87	Yes	Yes	0	7	9
18	R:R:L59	R:R:L87	4.15	No	Yes	4	5	7
19	R:R:L60	R:R:L63	4.15	No	No	5	7	4
20	R:R:I322	R:R:L60	2.85	Yes	No	5	6	7
21	R:R:V61	R:R:Y319	3.79	No	Yes	0	9	5
22	R:R:I62	R:R:V80	3.07	Yes	No	0	7	6
23	R:R:A83	R:R:I62	3.25	No	Yes	0	9	7
24	R:R:I62	R:R:L84	5.71	Yes	No	0	7	6
25	R:R:I322	R:R:L63	5.71	Yes	No	5	6	4
26	R:R:S64	R:R:Y319	5.09	No	Yes	0	8	5
27	R:R:I322	R:R:S64	4.64	Yes	No	0	6	8
28	R:R:V65	R:R:V80	4.81	No	No	0	7	6
29	R:R:F315	R:R:V65	2.62	Yes	No	0	8	7
30	R:R:L66	R:R:R72	3.64	No	No	0	3	6
31	R:R:N68	R:R:R67	3.62	No	No	0	5	5
32	R:R:I322	R:R:R67	3.76	Yes	No	0	6	5
33	R:R:L71	R:R:N68	8.24	No	No	0	7	5
34	R:R:E318	R:R:N68	15.77	No	No	0	6	5
35	R:R:R69	R:R:R72	11.73	No	No	0	6	6
36	R:R:L71	R:R:N314	4.12	No	No	0	7	6
37	R:R:N73	R:R:R72	8.44	No	No	0	7	6
38	R:R:A74	R:R:N76	4.69	No	No	0	6	8
39	R:R:G75	R:R:N137	3.39	No	No	0	7	8
40	R:R:G75	R:R:R153	6	No	No	0	7	7
41	R:R:F315	R:R:N76	4.83	Yes	No	0	8	8
42	R:R:L77	R:R:T157	4.42	No	No	0	5	7
43	R:R:I161	R:R:L77	2.85	No	No	0	7	5
44	R:R:A133	R:R:F78	2.77	No	No	0	6	7
45	R:R:F78	R:R:H160	7.92	No	No	0	7	5
46	R:R:F78	R:R:I161	3.77	No	No	0	7	7
47	R:R:I134	R:R:L79	4.28	No	No	2	9	8
48	R:R:L79	R:R:Y308	3.52	No	Yes	2	8	9
49	R:R:N130	R:R:S81	2.98	No	No	0	8	9
50	R:R:I161	R:R:S81	7.74	No	No	0	7	9
51	R:R:L82	R:R:N130	6.87	No	No	0	9	8
52	R:R:I131	R:R:L82	2.85	Yes	No	0	9	9
53	R:R:A85	R:R:W165	5.19	No	No	0	8	9
54	R:R:D86	R:R:V89	2.92	Yes	Yes	0	9	7
55	R:R:D86	R:R:S127	7.36	Yes	No	0	9	9
56	R:R:D86	R:R:S301	4.42	Yes	No	0	9	9
57	R:R:D86	R:R:N304	2.69	Yes	No	0	9	9
58	R:R:F91	R:R:L87	9.74	No	Yes	0	5	7
59	R:R:P93	R:R:V89	8.84	Yes	Yes	1	6	7
60	R:R:V89	R:R:Y94	11.36	Yes	Yes	1	7	7
61	R:R:M120	R:R:V89	3.04	Yes	Yes	1	5	7
62	R:R:S123	R:R:V89	9.7	No	Yes	0	8	7
63	R:R:P93	R:R:Y92	2.78	Yes	No	1	6	6
64	R:R:V119	R:R:Y92	6.31	No	No	1	4	6
65	R:R:P93	R:R:V119	10.6	Yes	No	1	6	4
66	R:R:M120	R:R:P93	3.35	Yes	Yes	1	5	6
67	R:R:Y298	R:R:Y94	5.96	No	Yes	0	7	7
68	R:R:S301	R:R:Y94	3.82	No	Yes	0	9	7
69	R:R:F108	R:R:L96	6.09	Yes	No	0	6	5
70	R:R:I97	R:R:S189	4.64	No	No	0	5	4
71	R:R:F102	R:R:L98	6.09	No	No	0	4	6
72	R:R:F108	R:R:V99	6.55	Yes	No	0	6	4
73	R:R:A107	R:R:Y103	8.01	No	No	0	3	4
74	R:R:G105	R:R:Y183	2.9	No	Yes	0	4	2
75	R:R:F108	R:R:W106	4.01	Yes	Yes	0	6	8
76	R:R:C113	R:R:W106	5.22	No	Yes	0	9	8
77	R:R:W106	R:R:Y183	11.58	Yes	Yes	0	8	2
78	R:R:F108	R:R:H112	15.84	Yes	No	0	6	5
79	R:R:E110	R:R:K114	6.75	No	No	0	3	7
80	R:R:E111	R:R:H112	4.92	No	No	0	2	5
81	R:R:E111	R:R:K114	6.75	No	No	0	2	7
82	R:R:C190	R:R:S116	3.44	No	No	0	9	4
83	R:R:A117	R:R:L181	3.15	No	No	0	5	3
84	R:R:F118	R:R:L172	10.96	No	No	0	6	7
85	R:R:F118	R:R:F176	16.08	No	No	0	6	5
86	R:R:M120	R:R:V124	3.04	Yes	No	0	5	7
87	L:L:?1	R:R:M120	3.56	Yes	Yes	1	0	5
88	L:L:?1	R:R:G121	5.74	Yes	No	0	0	4
89	R:R:L122	R:R:W165	4.56	No	No	0	5	9
90	R:R:L122	R:R:T168	2.95	No	No	0	5	7
91	R:R:S123	R:R:V124	3.23	No	No	0	8	7
92	R:R:H208	R:R:V124	2.77	No	No	0	5	7
93	R:R:I125	R:R:T168	3.04	No	No	0	7	7
94	L:L:?1	R:R:I125	5.98	Yes	No	0	0	7
95	R:R:G126	R:R:W165	2.81	No	No	0	7	9
96	R:R:I131	R:R:V128	4.61	Yes	Yes	2	9	7
97	R:R:H208	R:R:V128	9.69	No	Yes	0	5	7
98	R:R:P212	R:R:V128	3.53	No	Yes	0	9	7
99	R:R:F260	R:R:V128	2.62	No	Yes	2	9	7
100	R:R:I207	R:R:W129	5.87	No	No	0	4	5
101	R:R:F260	R:R:I131	8.79	No	Yes	2	9	9
102	R:R:I131	R:R:N304	2.83	Yes	No	0	9	9
103	R:R:I131	R:R:Y308	6.04	Yes	Yes	2	9	9
104	R:R:P212	R:R:T132	3.5	No	No	0	9	8
105	R:R:T132	R:R:V215	4.76	No	Yes	0	8	6
106	R:R:T132	R:R:V216	3.17	No	No	0	8	8
107	R:R:I134	R:R:R138	5.01	No	Yes	2	9	9
108	R:R:I134	R:R:Y308	6.04	No	Yes	2	9	9
109	R:R:A135	R:R:V216	5.09	No	No	0	9	8
110	R:R:A135	R:R:Y220	2.67	No	No	0	9	9
111	R:R:I136	R:R:V215	3.07	No	Yes	0	6	6
112	R:R:N137	R:R:Y148	3.49	No	No	0	8	5
113	R:R:R138	R:R:Y220	8.23	Yes	No	2	9	9
114	R:R:F257	R:R:R138	3.21	Yes	Yes	2	8	9
115	R:R:R138	R:R:Y308	3.09	Yes	Yes	2	9	9
116	R:R:C143	R:R:Y139	4.03	No	Yes	0	7	8
117	R:R:C219	R:R:Y139	9.41	No	Yes	0	7	8
118	R:R:I223	R:R:Y139	6.04	No	Yes	0	8	8
119	R:R:I142	R:R:I223	7.36	No	No	0	9	8
120	R:R:C143	R:R:H144	4.42	No	No	0	7	6
121	R:R:C143	R:R:L226	3.17	No	No	0	7	5
122	R:R:H149	R:R:Y148	3.27	No	No	0	3	5
123	R:R:R153	R:R:Y148	9.26	No	No	0	7	5
124	R:R:R153	R:R:T157	15.52	No	No	0	7	7
125	R:R:R154	R:R:W155	8	No	No	0	3	4
126	R:R:H156	R:R:W155	27.51	No	No	0	5	4
127	R:R:P158	R:R:T157	3.5	No	No	0	1	7
128	R:R:L163	R:R:L167	4.15	No	No	0	4	4
129	R:R:I164	R:R:L167	2.85	No	No	0	6	4
130	R:R:L172	R:R:N175	5.49	No	Yes	0	7	5
131	L:L:?1	R:R:L172	4.64	Yes	No	0	0	7
132	R:R:L173	R:R:P174	3.28	No	No	0	4	7
133	R:R:P174	R:R:Y200	9.74	No	No	0	7	6
134	R:R:N175	R:R:S180	4.47	Yes	Yes	1	5	4
135	R:R:L181	R:R:N175	6.87	No	Yes	1	3	5
136	R:R:F192	R:R:N175	4.83	Yes	Yes	1	4	5
137	R:R:S180	R:R:V178	3.23	Yes	No	0	4	3
138	R:R:L181	R:R:S180	4.5	No	Yes	1	3	4
139	R:R:F192	R:R:S180	2.64	Yes	Yes	1	4	4
140	R:R:D184	R:R:E182	7.8	Yes	No	3	4	1
141	R:R:E182	R:R:I193	4.1	No	No	3	1	4
142	R:R:P185	R:R:Y183	5.56	No	Yes	0	1	2
143	R:R:Y183	R:R:Y188	2.98	Yes	No	0	2	5
144	R:R:D184	R:R:R186	3.57	Yes	Yes	0	4	3
145	R:R:D184	R:R:I187	4.2	Yes	Yes	3	4	1
146	R:R:D184	R:R:I193	4.2	Yes	No	3	4	4
147	R:R:I285	R:R:R186	3.76	No	Yes	0	3	3
148	R:R:E287	R:R:R186	4.65	No	Yes	0	4	3
149	R:R:F290	R:R:R186	13.9	Yes	Yes	0	4	3
150	R:R:I187	R:R:S189	9.29	Yes	No	0	1	4
151	R:R:F290	R:R:I187	5.02	Yes	Yes	3	4	1
152	R:R:I187	R:R:Y294	6.04	Yes	Yes	3	1	5
153	R:R:S189	R:R:Y298	3.82	No	No	0	4	7
154	R:R:T191	R:R:Y294	11.24	No	Yes	0	4	5
155	L:L:?1	R:R:T191	6.18	Yes	No	0	0	4
156	R:R:F192	R:R:V204	2.62	Yes	No	1	4	5
157	L:L:?1	R:R:F192	24.51	Yes	Yes	1	0	4
158	R:R:I193	R:R:T195	3.04	No	No	0	4	4
159	R:R:Q194	R:R:T201	4.25	No	No	0	4	4
160	R:R:Q194	R:R:V274	5.73	No	No	0	4	3
161	R:R:F290	R:R:Q194	4.68	Yes	No	0	4	4
162	R:R:Q199	R:R:S197	4.33	No	No	0	3	5
163	R:R:Q199	R:R:T198	9.92	No	No	0	3	3
164	R:R:A203	R:R:Y200	2.67	No	No	0	2	6
165	R:R:A275	R:R:T201	3.36	No	No	0	4	4
166	L:L:?1	R:R:V204	11.24	Yes	No	1	0	5
167	R:R:N268	R:R:V205	5.91	No	No	0	7	5
168	R:R:L272	R:R:V205	4.47	No	No	0	6	5
169	R:R:H208	R:R:W264	4.23	No	Yes	0	5	8
170	R:R:F209	R:R:I213	5.02	No	No	0	8	6
171	R:R:F209	R:R:N268	20.54	No	No	0	8	7
172	R:R:L211	R:R:P212	4.93	No	No	0	5	9
173	R:R:L211	R:R:V215	2.98	No	Yes	0	5	6
174	R:R:F260	R:R:I213	5.02	No	No	0	9	6
175	R:R:A261	R:R:I213	3.25	No	No	0	5	6
176	R:R:F254	R:R:S217	2.64	Yes	No	0	6	5
177	R:R:F218	R:R:R222	8.55	No	No	0	4	5
178	R:R:F257	R:R:Y220	17.54	Yes	No	2	8	9
179	R:R:F254	R:R:L221	6.09	Yes	No	0	6	4
180	R:R:L228	R:R:W224	4.56	No	Yes	0	5	5
181	R:R:F250	R:R:W224	13.03	No	Yes	0	6	5
182	R:R:L228	R:R:R232	7.29	No	No	0	5	4
183	R:R:F250	R:R:F254	8.57	No	Yes	0	6	6
184	R:R:M253	R:R:T252	6.02	No	No	0	7	8
185	R:R:F257	R:R:V256	7.87	Yes	No	0	8	8
186	R:R:F257	R:R:Y308	6.19	Yes	Yes	2	8	9
187	R:R:C263	R:R:L296	6.35	No	No	0	8	7
188	R:R:L267	R:R:W264	5.69	No	Yes	0	6	8
189	R:R:A297	R:R:W264	5.19	No	Yes	0	7	8
190	R:R:N300	R:R:W264	11.3	No	Yes	0	9	8
191	R:R:P266	R:R:S293	3.56	No	No	0	9	5
192	R:R:L267	R:R:Y294	9.38	No	Yes	0	6	5
193	L:L:?1	R:R:L267	5.8	Yes	No	0	0	6
194	R:R:I270	R:R:I285	5.89	No	No	0	4	3
195	R:R:A282	R:R:V274	3.39	No	No	0	2	3
196	R:R:I276	R:R:N277	7.08	No	No	0	4	3
197	R:R:E280	R:R:N277	13.15	No	No	0	2	3
198	R:R:P278	R:R:Q279	9.47	No	No	0	2	1
199	R:R:E280	R:R:Q279	6.37	No	No	0	2	1
200	R:R:I285	R:R:P286	3.39	No	No	0	3	5
201	R:R:G288	R:R:V291	3.68	No	No	0	3	4
202	R:R:F290	R:R:Y294	12.38	Yes	Yes	3	4	5
203	R:R:L295	R:R:V291	2.98	Yes	No	0	5	4
204	R:R:Y294	R:R:Y298	8.94	Yes	No	0	5	7
205	R:R:C302	R:R:F299	2.79	No	No	0	7	5
206	R:R:L303	R:R:N300	2.75	No	No	0	6	9
207	R:R:N300	R:R:N304	6.81	No	No	0	9	9
208	R:R:I306	R:R:L303	2.85	No	No	0	6	6
209	R:R:V307	R:R:Y308	3.79	No	Yes	0	8	9
210	R:R:Q313	R:R:R316	9.35	No	No	0	4	8
211	R:R:F315	R:R:Y319	9.28	Yes	Yes	0	8	5
212	R:R:E318	R:R:R321	4.65	No	No	0	6	5
213	R:R:E318	R:R:I322	4.1	No	Yes	0	6	6
214	R:R:S197	R:R:Y200	2.54	No	No	0	5	6
215	R:R:V99	R:R:Y103	2.52	No	No	0	4	4
216	R:R:M146	R:R:R150	2.48	No	No	0	5	4
217	R:R:V225	R:R:W224	2.45	No	Yes	0	3	5
218	R:R:F177	R:R:L173	2.44	No	No	0	4	4
219	R:R:F315	R:R:N312	2.42	Yes	No	0	8	8
220	R:R:I125	R:R:W129	2.35	No	No	0	7	5
221	R:R:L140	R:R:Y139	2.34	No	Yes	0	4	8
222	R:R:L310	R:R:Y319	2.34	No	Yes	0	6	5
223	R:R:L159	R:R:W155	2.28	No	No	0	2	4
224	R:R:H149	R:R:Y141	2.18	No	No	0	3	8
225	R:R:H156	R:R:Y152	2.18	No	No	0	5	6
226	R:R:R222	R:R:Y139	2.06	No	Yes	0	5	8
227	R:R:A40	R:R:P41	1.87	No	No	0	4	3
228	R:R:A265	R:R:P266	1.87	No	No	0	6	9
229	R:R:A282	R:R:P283	1.87	No	No	0	2	1
230	R:R:G57	R:R:V56	1.84	No	No	0	8	5
231	R:R:G179	R:R:V178	1.84	No	No	0	4	3
232	R:R:G271	R:R:V274	1.84	No	No	0	4	3
233	R:R:C113	R:R:C190	1.82	No	No	0	9	9
234	R:R:A117	R:R:C190	1.81	No	No	0	5	9
235	R:R:G57	R:R:L60	1.71	No	No	0	8	7
236	R:R:A196	R:R:S180	1.71	No	Yes	0	4	4
237	R:R:C219	R:R:V215	1.71	No	Yes	0	7	6
238	R:R:A90	R:R:V55	1.7	No	No	0	7	5
239	R:R:A261	R:R:V258	1.7	No	No	0	5	4
240	R:R:L296	R:R:P266	1.64	No	No	0	7	9
241	R:R:L289	R:R:P286	1.64	No	No	0	4	5
242	R:R:E287	R:R:G288	1.64	No	No	0	4	3
243	R:R:A133	R:R:I164	1.62	No	No	0	6	6
244	R:R:A147	R:R:I151	1.62	No	No	0	4	3
245	R:R:S197	R:R:V178	1.62	No	No	0	5	3
246	R:R:S217	R:R:V258	1.62	No	No	0	5	4
247	R:R:A273	R:R:M281	1.61	No	No	0	4	1
248	R:R:V49	R:R:V53	1.6	No	No	0	5	5
249	R:R:V119	R:R:V88	1.6	No	No	0	4	6
250	R:R:S293	R:R:T292	1.6	No	No	0	5	5
251	R:R:T50	R:R:V49	1.59	No	No	0	7	5
252	R:R:T168	R:R:V169	1.59	No	No	0	7	3
253	R:R:A42	R:R:L295	1.58	No	Yes	0	4	5
254	R:R:C302	R:R:D54	1.56	No	No	0	7	8
255	R:R:A305	R:R:N58	1.56	No	Yes	0	9	9
256	R:R:I48	R:R:S44	1.55	No	No	0	4	5
257	R:R:I270	R:R:S293	1.55	No	No	0	4	5
258	R:R:I259	R:R:V307	1.54	No	No	0	6	8
259	R:R:F108	R:R:G109	1.51	Yes	No	0	6	8
260	R:R:L295	R:R:V46	1.49	Yes	No	0	5	6
261	R:R:L251	R:R:V255	1.49	No	No	0	5	6
262	R:R:I101	R:R:I97	1.47	No	No	0	4	5
263	R:R:I259	R:R:I262	1.47	No	No	0	6	5
264	R:R:G309	R:R:Y319	1.45	No	Yes	0	7	5
265	R:R:I62	R:R:L66	1.43	Yes	No	0	7	3
266	R:R:Q229	R:R:V225	1.43	No	No	0	4	3
267	R:R:M281	R:R:N277	1.4	No	No	0	1	3
268	R:R:P95	R:R:Y94	1.39	No	Yes	0	8	7
269	R:R:L310	R:R:L311	1.38	No	No	0	6	7
270	R:R:M281	R:R:Q284	1.36	No	No	0	1	3
271	R:R:H144	R:R:M146	1.31	No	No	0	6	5
272	R:R:R231	R:R:V227	1.31	No	No	0	4	8
273	R:R:F254	R:R:V255	1.31	Yes	No	0	6	6
274	R:R:A100	R:R:W106	1.3	No	Yes	0	4	8
275	R:R:I151	R:R:R150	1.25	No	No	0	3	4
276	R:R:K320	R:R:R316	1.24	No	No	0	4	8
277	R:R:F209	R:R:L210	1.22	No	No	0	8	4
278	R:R:K320	R:R:Y319	1.19	No	Yes	0	4	5
279	R:R:Q313	R:R:R317	1.17	No	No	0	4	4
280	R:R:M253	R:R:W224	1.16	No	Yes	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L47	6.5375	4	1	6
2	R:R:N58	5.635	4	0	9
3	R:R:I62	3.365	4	0	7
4	R:R:D86	4.808	5	0	9
5	R:R:L87	6.68	4	4	7
6	R:R:V89	7.172	5	1	7
7	R:R:P93	6.3925	4	1	6
8	R:R:Y94	7.93333	6	1	7
9	R:R:W106	5.5275	4	0	8
10	R:R:F108	6.8	5	0	6
11	R:R:M120	3.2475	4	1	5
12	R:R:V128	5.1125	4	2	7
13	R:R:I131	5.024	5	2	9
14	R:R:R138	4.885	4	2	9
15	R:R:Y139	4.776	5	0	8
16	R:R:N175	5.415	4	1	5
17	R:R:S180	3.31	5	1	4
18	R:R:Y183	5.755	4	0	2
19	R:R:D184	4.9425	4	3	4
20	R:R:R186	6.47	4	0	3
21	R:R:I187	6.1375	4	3	1
22	R:R:F192	8.65	4	1	4
23	R:R:V215	3.13	4	0	6
24	R:R:W224	5.3	4	0	5
25	R:R:F254	4.6525	4	0	6
26	R:R:F257	8.7025	4	2	8
27	R:R:W264	6.6025	4	0	8
28	R:R:F290	8.995	4	3	4
29	R:R:Y294	9.596	5	3	5
30	R:R:L295	2.55	4	0	5
31	R:R:Y308	4.77833	6	2	9
32	R:R:F315	4.7875	4	0	8
33	R:R:Y319	3.85667	6	0	5
34	R:R:I322	4.212	5	5	6
35	L:L:?1	8.45625	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G288	R:R:V291	11.4996	3.68	No	No	0	3	4
2	R:R:L47	R:R:Y94	13.6104	17.58	Yes	Yes	1	6	7
3	R:R:Y298	R:R:Y94	19.966	5.96	No	Yes	0	7	7
4	R:R:Y294	R:R:Y298	19.7962	8.94	Yes	No	0	5	7
5	R:R:F290	R:R:Y294	50.4438	12.38	Yes	Yes	3	4	5
6	R:R:F290	R:R:R186	38.0759	13.9	Yes	Yes	0	4	3
7	R:R:E287	R:R:R186	19.0438	4.65	No	Yes	0	4	3
8	R:R:E287	R:R:G288	17.1876	1.64	No	No	0	4	3
9	R:R:D54	R:R:D86	60.6622	6.65	No	Yes	0	8	9
10	R:R:D86	R:R:V89	49.5678	2.92	Yes	Yes	0	9	7
11	R:R:V89	R:R:Y94	22.8294	11.36	Yes	Yes	1	7	7
12	R:R:D86	R:R:S301	15.5129	4.42	Yes	No	0	9	9
13	R:R:S301	R:R:Y94	15.127	3.82	No	Yes	0	9	7
14	R:R:D54	R:R:N58	54.3876	9.42	No	Yes	0	8	9
15	R:R:A83	R:R:N58	46.7161	4.69	No	Yes	0	9	9
16	R:R:I322	R:R:S64	18.9589	4.64	Yes	No	0	6	8
17	R:R:S64	R:R:Y319	20.2555	5.09	No	Yes	0	8	5
18	R:R:F315	R:R:Y319	31.5698	9.28	Yes	Yes	0	8	5
19	R:R:F315	R:R:V65	36.2815	2.62	Yes	No	0	8	7
20	R:R:V65	R:R:V80	37.4778	4.81	No	No	0	7	6
21	R:R:I62	R:R:V80	38.6664	3.07	Yes	No	0	7	6
22	R:R:A83	R:R:I62	45.5854	3.25	No	Yes	0	9	7
23	R:R:R153	R:R:T157	16.4351	15.52	No	No	0	7	7
24	R:R:L77	R:R:T157	21.2433	4.42	No	No	0	5	7
25	R:R:I161	R:R:L77	23.6436	2.85	No	No	0	7	5
26	R:R:I161	R:R:S81	40.1752	7.74	No	No	0	7	9
27	R:R:N130	R:R:S81	42.506	2.98	No	No	0	8	9
28	R:R:L82	R:R:N130	44.829	6.87	No	No	0	9	8
29	R:R:I131	R:R:L82	47.1444	2.85	Yes	No	0	9	9
30	R:R:I131	R:R:V128	43.2044	4.61	Yes	Yes	2	9	7
31	R:R:H208	R:R:V128	87.1266	9.69	No	Yes	0	5	7
32	R:R:H208	R:R:W264	49.3749	4.23	No	Yes	0	5	8
33	R:R:L267	R:R:W264	67.2069	5.69	No	Yes	0	6	8
34	R:R:L267	R:R:Y294	35.2667	9.38	No	Yes	0	6	5
35	R:R:I131	R:R:N304	57.5095	2.83	Yes	No	0	9	9
36	R:R:N300	R:R:N304	19.4181	6.81	No	No	0	9	9
37	R:R:N300	R:R:W264	19.5107	11.3	No	Yes	0	9	8
38	R:R:F78	R:R:I161	14.6523	3.77	No	No	0	7	7
39	R:R:I131	R:R:Y308	26.2484	6.04	Yes	Yes	2	9	9
40	R:R:I125	R:R:T168	11.6424	3.04	No	No	0	7	7
41	L:L:?1	R:R:I125	17.3613	5.98	Yes	No	0	0	7
42	L:L:?1	R:R:T191	17.1876	6.18	Yes	No	0	0	4
43	R:R:T191	R:R:Y294	16.3695	11.24	No	Yes	0	4	5
44	L:L:?1	R:R:L267	63.2708	5.8	Yes	No	0	0	6
45	L:L:?1	R:R:M120	73.4314	3.56	Yes	Yes	1	0	5
46	R:R:F108	R:R:W106	50.6251	4.01	Yes	Yes	0	6	8
47	R:R:C113	R:R:W106	80.6321	5.22	No	Yes	0	9	8
48	R:R:C113	R:R:C190	85.6062	1.82	No	No	0	9	9
49	R:R:A117	R:R:C190	95.049	1.81	No	No	0	5	9
50	R:R:A117	R:R:L181	100	3.15	No	No	0	5	3
51	R:R:L181	R:R:N175	69.1981	6.87	No	Yes	1	3	5
52	R:R:L172	R:R:N175	36.3279	5.49	No	Yes	0	7	5
53	L:L:?1	R:R:L172	40.5804	4.64	Yes	No	0	0	7
54	R:R:F192	R:R:N175	36.2661	4.83	Yes	Yes	1	4	5
55	L:L:?1	R:R:F192	91.7921	24.51	Yes	Yes	1	0	4
56	R:R:L181	R:R:S180	35.5715	4.5	No	Yes	1	3	4
57	R:R:F192	R:R:S180	54.4648	2.64	Yes	Yes	1	4	4
58	R:R:F108	R:R:V99	15.2659	6.55	Yes	No	0	6	4
59	R:R:V99	R:R:Y103	10.1837	2.52	No	No	0	4	4
60	R:R:W106	R:R:Y183	20.3404	11.58	Yes	Yes	0	8	2
61	R:R:F108	R:R:H112	20.3404	15.84	Yes	No	0	6	5
62	R:R:E111	R:R:K114	10.1837	6.75	No	No	0	2	7
63	R:R:E111	R:R:H112	15.2659	4.92	No	No	0	2	5
64	R:R:M120	R:R:V124	37.8907	3.04	Yes	No	0	5	7
65	R:R:H208	R:R:V124	39.3378	2.77	No	No	0	5	7
66	R:R:P212	R:R:V128	55.5568	3.53	No	Yes	0	9	7
67	R:R:F260	R:R:V128	23.3272	2.62	No	Yes	2	9	7
68	R:R:P212	R:R:T132	28.4055	3.5	No	No	0	9	8
69	R:R:T132	R:R:V215	24.8514	4.76	No	Yes	0	8	6
70	R:R:L211	R:R:V215	24.3073	2.98	No	Yes	0	5	6
71	R:R:L211	R:R:P212	25.7853	4.93	No	No	0	5	9
72	R:R:C143	R:R:Y139	21.664	4.03	No	Yes	0	7	8
73	R:R:C219	R:R:Y139	40.1212	9.41	No	Yes	0	7	8
74	R:R:C219	R:R:V215	43.1697	1.71	No	Yes	0	7	6
75	R:R:C143	R:R:H144	15.6633	4.42	No	No	0	7	6
76	R:R:S197	R:R:V178	14.1352	1.62	No	No	0	5	3
77	R:R:S180	R:R:V178	17.5928	3.23	Yes	No	0	4	3
78	R:R:I285	R:R:R186	19.0322	3.76	No	Yes	0	3	3
79	R:R:F290	R:R:Q194	13.128	4.68	Yes	No	0	4	4
80	R:R:F260	R:R:I213	32.0367	5.02	No	No	0	9	6
81	R:R:A261	R:R:I213	23.1921	3.25	No	No	0	5	6
82	R:R:F254	R:R:S217	18.6656	2.64	Yes	No	0	6	5
83	R:R:S217	R:R:V258	20.1821	1.62	No	No	0	5	4
84	R:R:A261	R:R:V258	21.691	1.7	No	No	0	5	4
85	R:R:F250	R:R:W224	10.9632	13.03	No	Yes	0	6	5
86	R:R:F250	R:R:F254	12.5222	8.57	No	Yes	0	6	6
87	R:R:I270	R:R:S293	11.515	1.55	No	No	0	4	5
88	R:R:I270	R:R:I285	13.4097	5.89	No	No	0	4	3
89	R:R:H144	R:R:M146	12.5453	1.31	No	No	0	6	5
90	R:R:D86	R:R:N304	42.4442	2.69	Yes	No	0	9	9
91	R:R:M120	R:R:V89	38.3384	3.04	Yes	Yes	1	5	7
92	R:R:F260	R:R:I131	10.1528	8.79	No	Yes	2	9	9
93	R:R:I187	R:R:Y294	11.133	6.04	Yes	Yes	3	1	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P93	R:R:V89	8.84	1	Yes	Yes	6	7	2	2
R:R:M120	R:R:V89	3.04	1	Yes	Yes	5	7	1	2
R:R:M120	R:R:P93	3.35	1	Yes	Yes	5	6	1	2
R:R:F118	R:R:L172	10.96	0	No	No	6	7	2	1
R:R:M120	R:R:V124	3.04	1	Yes	No	5	7	1	2
L:L:?1	R:R:M120	3.56	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:G121	5.74	1	Yes	No	0	4	0	1
R:R:I125	R:R:T168	3.04	0	No	No	7	7	1	2
L:L:?1	R:R:I125	5.98	1	Yes	No	0	7	0	1
R:R:L172	R:R:N175	5.49	0	No	Yes	7	5	1	2
L:L:?1	R:R:L172	4.64	1	Yes	No	0	7	0	1
R:R:N175	R:R:S180	4.47	1	Yes	Yes	5	4	2	2
R:R:F192	R:R:N175	4.83	1	Yes	Yes	4	5	1	2
R:R:F192	R:R:S180	2.64	1	Yes	Yes	4	4	1	2
R:R:T191	R:R:Y294	11.24	0	No	Yes	4	5	1	2
L:L:?1	R:R:T191	6.18	1	Yes	No	0	4	0	1
R:R:F192	R:R:V204	2.62	1	Yes	No	4	5	1	1
L:L:?1	R:R:F192	24.51	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:V204	11.24	1	Yes	No	0	5	0	1
R:R:L267	R:R:W264	5.69	0	No	Yes	6	8	1	2
R:R:L267	R:R:Y294	9.38	0	No	Yes	6	5	1	2
L:L:?1	R:R:L267	5.8	1	Yes	No	0	6	0	1
R:R:I125	R:R:W129	2.35	0	No	No	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VH0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	254
Number of Links	280
Number of Hubs	35
Number of Links mediated by Hubs	132
Number of Communities	5
Number of Nodes involved in Communities	35
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	68959
Length Of Smallest Path	3
Average Path Length	14.9019
Length of Longest Path	30
Minimum Path Strength	1.215
Average Path Strength	5.64084
Maximum Path Strength	17.755
Minimum Path Correlation	0.7
Average Path Correlation	0.928894
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	46.3613
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.5794
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JEV
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JEV
Name	Ramelteon
Synonyms	Ramelteon
Identifier
Formula	C16 H21 N O2
Molecular Weight	259.343
SMILES
PubChem	208902
Formal Charge	0
Total Atoms	40
Total Chiral Atoms	1
Total Bonds	42
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49286
Sequence	>7VH0_nogp_Chain_R W V A P A L S A V L I V T T A V D V V G N L L V I L S V L R N R K L R N A G N L F L V S L A L A D L V V A F Y P Y P L I L V A I F Y D G W A F G E E H C K A S A F V M G L S V I G S V W N I T A I A I N R Y L Y I C H S M A Y H R I Y R R W H T P L H I C L I W L L T V V A L L P N F F V G S L E Y D P R I Y S C T F I Q T A S T Q Y T A A V V V I H F L L P I A V V S F C Y L R I W V L V L Q A R R K A K S F L T M F V V F V I F A I C W A P L N C I G L A V A I N P Q E M A P Q I P E G L F V T S Y L L A Y F N S C L N A I V Y G L L N Q N F R R E Y K R I L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VH0	A	Melatonin	Melatonin	MT₂	Homo sapiens	Ramelteon	-	Gi1/β1/γ1	3.46	2022-03-02	doi.org/10.1038/s41467-022-28111-3
	7VH0 (No Gprot)	A	Melatonin	Melatonin	MT₂	Homo sapiens	Ramelteon	-		3.46	2022-03-02	doi.org/10.1038/s41467-022-28111-3
	6ME6	A	Melatonin	Melatonin	MT₂	Homo sapiens	2-Phenylmelatonin	-	-	2.8	2019-04-24	doi.org/10.1038/s41586-019-1144-0
	6ME7	A	Melatonin	Melatonin	MT₂	Homo sapiens	2-Phenylmelatonin	-	-	3.2	2019-04-24	doi.org/10.1038/s41586-019-1144-0
	6ME8	A	Melatonin	Melatonin	MT₂	Homo sapiens	2-Phenylmelatonin	-	-	3.1	2019-04-24	doi.org/10.1038/s41586-019-1144-0
	6ME9	A	Melatonin	Melatonin	MT₂	Homo sapiens	Ramelteon	-	-	3.3	2019-04-24	doi.org/10.1038/s41586-019-1144-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7VH0_nogp.zip

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