psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:Q210	8.65	No	No	0	0	7
2	L:L:H1	R:R:I213	11.93	No	Yes	0	0	5
3	L:L:S2	R:R:Q356	4.33	No	Yes	2	0	7
4	L:L:S2	R:R:E360	10.06	No	Yes	2	0	7
5	L:L:D3	R:R:Y134	5.75	Yes	Yes	2	0	7
6	L:L:D3	R:R:R172	4.76	Yes	Yes	2	0	8
7	L:L:D3	R:R:V176	5.84	Yes	No	2	0	7
8	L:L:D3	R:R:I213	5.6	Yes	Yes	2	0	5
9	L:L:D3	R:R:L361	5.43	Yes	No	2	0	7
10	L:L:I5	R:R:Q356	4.12	No	Yes	0	0	7
11	L:L:F6	R:R:Y123	4.13	Yes	Yes	0	0	5
12	L:L:F6	R:R:V126	6.55	Yes	No	0	0	6
13	L:L:F6	R:R:Y130	8.25	Yes	Yes	2	0	7
14	L:L:F6	R:R:I357	3.77	Yes	No	0	0	6
15	L:L:F6	R:R:L361	4.87	Yes	No	2	0	7
16	L:L:T7	R:R:K179	12.01	No	Yes	0	0	6
17	L:L:T7	R:R:Y184	4.99	No	Yes	0	0	3
18	L:L:D8	L:L:R12	15.48	No	Yes	1	0	0
19	L:L:D8	R:R:T274	5.78	No	Yes	1	0	5
20	L:L:D8	R:R:N275	5.39	No	No	0	0	6
21	L:L:S9	R:R:Y123	7.63	No	Yes	0	0	5
22	L:L:R14	L:L:Y10	12.35	Yes	No	7	0	0
23	L:L:Y10	R:R:Y123	10.92	No	Yes	0	0	5
24	L:L:Y10	R:R:Y184	18.86	No	Yes	7	0	3
25	L:L:S11	R:R:Y184	5.09	No	Yes	0	0	3
26	L:L:S11	R:R:D273	8.83	No	Yes	0	0	6
27	L:L:R12	R:R:T274	5.17	Yes	Yes	1	0	5
28	L:L:R12	R:R:D276	10.72	Yes	No	1	0	3
29	L:L:M17	L:L:Y13	15.57	No	Yes	0	0	0
30	L:L:Y13	R:R:K119	5.97	Yes	No	0	0	3
31	L:L:Y13	R:R:I120	8.46	Yes	No	0	0	1
32	L:L:Y13	R:R:Y123	9.93	Yes	Yes	0	0	5
33	L:L:R14	R:R:E24	4.65	Yes	No	0	0	5
34	L:L:R14	R:R:C25	8.36	Yes	No	0	0	8
35	L:L:R14	R:R:R26	5.33	Yes	No	0	0	4
36	L:L:R14	R:R:Y184	9.26	Yes	Yes	7	0	3
37	L:L:K15	R:R:F82	13.65	No	No	0	0	5
38	L:L:Q16	R:R:F82	4.68	No	No	0	0	5
39	L:L:Q16	R:R:D113	5.22	No	No	5	0	1
40	L:L:Q16	R:R:D116	5.22	No	Yes	5	0	3
41	L:L:M17	R:R:D116	4.16	No	Yes	5	0	3
42	L:L:M17	R:R:E117	6.77	No	No	5	0	2
43	L:L:V19	R:R:F79	5.24	No	Yes	0	0	5
44	L:L:V19	R:R:F82	10.49	No	No	0	0	5
45	L:L:K20	R:R:Y111	7.17	No	No	0	0	1
46	L:L:K20	R:R:D116	8.3	No	Yes	5	0	3
47	L:L:K20	R:R:E117	6.75	No	No	5	0	2
48	L:L:Y22	R:R:H28	8.71	No	No	8	0	4
49	L:L:Y22	R:R:Q32	10.15	No	Yes	8	0	4
50	L:L:L27	L:L:V26	5.96	No	No	0	0	0
51	R:R:E24	R:R:S185	4.31	No	No	0	5	3
52	R:R:E24	R:R:L190	15.9	No	No	0	5	1
53	R:R:L29	R:R:R26	6.07	No	No	0	4	4
54	R:R:C192	R:R:R26	4.18	No	No	0	4	4
55	R:R:F27	R:R:W199	21.05	No	Yes	0	4	4
56	R:R:H28	R:R:Q32	13.6	No	Yes	8	4	4
57	R:R:I31	R:R:V78	7.68	No	No	0	6	5
58	R:R:E35	R:R:Q32	3.82	No	Yes	0	5	4
59	R:R:I59	R:R:Q32	6.86	No	Yes	0	6	4
60	R:R:E35	R:R:V78	9.98	No	No	0	5	5
61	R:R:T36	R:R:W56	9.7	No	No	0	3	7
62	R:R:C38	R:R:C61	7.28	No	No	0	9	9
63	R:R:A39	R:R:W56	3.89	No	No	0	1	7
64	R:R:P64	R:R:R43	5.76	No	No	0	5	1
65	R:R:H49	R:R:T46	4.11	No	No	0	2	2
66	R:R:K48	R:R:K50	4.31	No	No	0	1	1
67	R:R:C52	R:R:C93	7.28	Yes	Yes	4	9	9
68	R:R:C52	R:R:W98	18.28	Yes	Yes	4	9	8
69	R:R:G54	R:R:P64	4.06	No	No	0	5	5
70	R:R:D57	R:R:N58	10.77	No	Yes	0	9	6
71	R:R:N58	R:R:W62	9.04	Yes	Yes	4	6	9
72	R:R:K91	R:R:N58	6.99	Yes	Yes	4	8	6
73	R:R:N58	R:R:T101	7.31	Yes	No	4	6	5
74	R:R:F105	R:R:N58	8.46	No	Yes	0	7	6
75	R:R:T60	R:R:W62	13.34	No	Yes	0	5	9
76	R:R:V71	R:R:W62	3.68	No	Yes	0	7	9
77	R:R:K91	R:R:W62	11.6	Yes	Yes	4	8	9
78	R:R:E69	R:R:N66	10.52	No	No	0	5	1
79	R:R:N92	R:R:T70	5.85	No	No	0	4	5
80	R:R:S90	R:R:T72	9.59	No	No	0	4	5
81	R:R:C75	R:R:Y83	8.06	No	Yes	6	9	4
82	R:R:C109	R:R:C75	7.28	No	No	6	4	9
83	R:R:F79	R:R:P76	5.78	Yes	No	6	5	9
84	R:R:P76	R:R:Y83	4.17	No	Yes	6	9	4
85	R:R:F79	R:R:V78	13.11	Yes	No	0	5	5
86	R:R:F79	R:R:Y83	11.35	Yes	Yes	6	5	4
87	R:R:C109	R:R:Y83	13.44	No	Yes	6	4	4
88	R:R:S112	R:R:S84	6.52	No	No	0	4	4
89	R:R:F105	R:R:I89	10.05	No	No	0	7	7
90	R:R:K91	R:R:W98	6.96	Yes	Yes	4	8	8
91	R:R:K91	R:R:T101	12.01	Yes	No	4	8	5
92	R:R:C93	R:R:W98	3.92	Yes	Yes	4	9	8
93	R:R:D96	R:R:T94	7.23	No	No	0	4	5
94	R:R:F102	R:R:P103	4.33	No	No	0	5	7
95	R:R:D104	R:R:D107	10.65	No	No	0	7	4
96	R:R:D113	R:R:D116	7.98	No	Yes	5	1	3
97	R:R:D116	R:R:E117	9.09	Yes	No	5	3	2
98	R:R:I120	R:R:I124	5.89	No	No	0	1	1
99	R:R:F122	R:R:Y123	5.16	No	Yes	0	4	5
100	R:R:F122	R:R:V126	5.24	No	No	0	4	6
101	R:R:F122	R:R:L358	4.87	No	No	0	4	6
102	R:R:C362	R:R:V126	5.12	No	No	0	6	6
103	R:R:D180	R:R:K127	11.06	No	No	0	6	5
104	R:R:C362	R:R:I129	6.55	No	No	0	6	7
105	R:R:T131	R:R:Y130	3.75	No	Yes	0	6	7
106	R:R:Y130	R:R:Y134	6.95	Yes	Yes	2	7	7
107	R:R:D180	R:R:Y130	6.9	No	Yes	0	6	7
108	R:R:L361	R:R:Y130	14.07	No	Yes	2	7	7
109	R:R:G133	R:R:S365	3.71	No	No	0	9	9
110	R:R:F366	R:R:G133	9.03	No	No	0	7	9
111	R:R:R172	R:R:Y134	7.2	Yes	Yes	2	8	7
112	R:R:A173	R:R:Y134	4	No	Yes	0	7	7
113	R:R:V176	R:R:Y134	11.36	No	Yes	2	7	7
114	R:R:S365	R:R:Y134	7.63	No	Yes	0	9	7
115	R:R:G368	R:R:S137	3.71	No	No	0	9	9
116	R:R:I170	R:R:L138	4.28	Yes	No	0	7	6
117	R:R:L369	R:R:S140	4.5	No	No	0	6	7
118	R:R:F166	R:R:L141	4.87	No	Yes	0	8	9
119	R:R:F169	R:R:L141	7.31	Yes	Yes	9	8	9
120	R:R:I170	R:R:L141	4.28	Yes	Yes	0	7	9
121	R:R:G368	R:R:L141	5.13	No	Yes	9	9	9
122	R:R:C376	R:R:G144	3.92	No	No	0	8	9
123	R:R:C376	R:R:I147	4.91	No	No	0	8	8
124	R:R:L148	R:R:N159	5.49	No	Yes	0	7	8
125	R:R:L148	R:R:L163	4.15	No	No	0	7	6
126	R:R:C149	R:R:L163	4.76	No	No	0	3	6
127	R:R:E385	R:R:F151	13.99	No	Yes	0	7	7
128	R:R:F151	R:R:K389	9.93	Yes	No	0	7	4
129	R:R:E385	R:R:K153	8.1	No	No	0	7	6
130	R:R:L154	R:R:N159	4.12	Yes	Yes	0	8	8
131	R:R:E381	R:R:L154	6.63	No	Yes	0	9	8
132	R:R:L154	R:R:V382	5.96	Yes	No	0	8	9
133	R:R:H155	R:R:Y160	10.89	No	No	0	8	6
134	R:R:C156	R:R:R158	5.57	No	No	3	8	9
135	R:R:C156	R:R:N159	6.3	No	Yes	3	8	8
136	R:R:T157	R:R:Y226	8.74	No	Yes	0	7	7
137	R:R:N159	R:R:R158	6.03	Yes	No	3	8	9
138	R:R:H162	R:R:R158	4.51	Yes	No	3	9	9
139	R:R:E223	R:R:I161	6.83	Yes	No	0	9	9
140	R:R:I161	R:R:Y226	6.04	No	Yes	0	9	7
141	R:R:F241	R:R:I161	3.77	No	No	0	6	9
142	R:R:E223	R:R:H162	8.62	Yes	Yes	3	9	9
143	R:R:H162	R:R:L336	3.86	Yes	Yes	3	9	9
144	R:R:H162	R:R:Y375	7.62	Yes	No	3	9	8
145	R:R:N164	R:R:W219	15.82	No	Yes	10	8	9
146	R:R:L245	R:R:N164	4.12	No	No	0	6	8
147	R:R:N164	R:R:W249	5.65	No	Yes	10	8	9
148	R:R:F169	R:R:L165	6.09	Yes	No	0	8	9
149	R:R:E223	R:R:L165	11.93	Yes	No	0	9	9
150	R:R:F166	R:R:V371	3.93	No	No	0	8	9
151	R:R:L167	R:R:W249	4.56	No	Yes	0	4	9
152	R:R:N216	R:R:S168	7.45	Yes	No	0	8	9
153	R:R:S168	R:R:W219	7.41	No	Yes	0	9	9
154	R:R:F169	R:R:N216	16.92	Yes	Yes	0	8	8
155	R:R:F169	R:R:Q367	9.37	Yes	No	0	8	9
156	R:R:F169	R:R:G368	9.03	Yes	No	9	8	9
157	R:R:F169	R:R:V371	5.24	Yes	No	0	8	9
158	R:R:C212	R:R:L171	4.76	No	No	0	6	7
159	R:R:I213	R:R:R172	8.77	Yes	Yes	2	5	8
160	R:R:N216	R:R:R172	9.64	Yes	Yes	0	8	8
161	R:R:F217	R:R:R172	5.34	Yes	Yes	2	8	8
162	R:R:F208	R:R:S175	5.28	No	No	11	6	6
163	R:R:C212	R:R:S175	6.89	No	No	11	6	6
164	R:R:D180	R:R:K179	5.53	No	Yes	0	6	6
165	R:R:K179	R:R:L209	5.64	Yes	No	0	6	6
166	R:R:S205	R:R:V182	6.46	No	No	0	6	5
167	R:R:L183	R:R:Y184	10.55	No	Yes	0	6	3
168	R:R:D273	R:R:L183	9.5	Yes	No	0	6	6
169	R:R:H191	R:R:T189	6.85	No	No	0	3	1
170	R:R:H191	R:R:P193	9.15	No	No	0	3	3
171	R:R:P193	R:R:Q195	4.74	No	Yes	0	3	3
172	R:R:Q195	R:R:S197	8.66	Yes	No	0	3	3
173	R:R:Q195	R:R:S198	5.78	Yes	No	0	3	6
174	R:R:S198	R:R:W199	3.71	No	Yes	0	6	4
175	R:R:C202	R:R:C271	7.28	No	No	0	9	9
176	R:R:D268	R:R:K203	6.91	No	No	1	6	7
177	R:R:K203	R:R:W272	18.57	No	Yes	1	7	8
178	R:R:D273	R:R:L206	4.07	Yes	No	0	6	6
179	R:R:V207	R:R:W259	3.68	No	Yes	0	6	8
180	R:R:C212	R:R:F208	8.38	No	No	11	6	6
181	R:R:I213	R:R:L209	4.28	Yes	No	0	5	6
182	R:R:Q210	R:R:W259	10.95	No	Yes	1	7	8
183	R:R:I284	R:R:Q210	6.86	No	No	1	7	7
184	R:R:W249	R:R:Y211	7.72	Yes	Yes	0	9	8
185	R:R:P252	R:R:Y211	4.17	Yes	Yes	0	9	8
186	R:R:T253	R:R:Y211	6.24	No	Yes	0	5	8
187	R:R:I256	R:R:Y211	6.04	No	Yes	0	7	8
188	R:R:F218	R:R:M214	7.46	Yes	No	0	6	6
189	R:R:C255	R:R:M214	4.86	No	No	0	7	6
190	R:R:A215	R:R:P252	3.74	No	Yes	0	8	9
191	R:R:L220	R:R:N216	4.12	No	Yes	0	9	8
192	R:R:F217	R:R:I288	12.56	Yes	No	0	8	8
193	R:R:F217	R:R:I292	5.02	Yes	Yes	2	8	7
194	R:R:F217	R:R:Y341	15.47	Yes	Yes	2	8	8
195	R:R:F218	R:R:L251	8.53	Yes	No	0	6	4
196	R:R:F218	R:R:P252	8.67	Yes	Yes	0	6	9
197	R:R:F218	R:R:S291	3.96	Yes	No	0	6	8
198	R:R:V222	R:R:W219	6.13	No	Yes	0	8	9
199	R:R:G248	R:R:W219	9.85	No	Yes	0	9	9
200	R:R:W219	R:R:W249	20.62	Yes	Yes	10	9	9
201	R:R:L220	R:R:Q367	3.99	No	No	0	9	9
202	R:R:L221	R:R:S291	9.01	No	No	0	8	8
203	R:R:V222	R:R:Y244	5.05	No	Yes	0	8	7
204	R:R:E223	R:R:L336	9.28	Yes	Yes	3	9	9
205	R:R:F337	R:R:G224	6.02	Yes	No	0	8	9
206	R:R:L230	R:R:Y226	14.07	No	Yes	0	7	7
207	R:R:Y226	R:R:Y244	6.95	Yes	Yes	0	7	7
208	R:R:L227	R:R:L231	4.15	No	No	0	9	8
209	R:R:I302	R:R:L227	7.14	No	No	0	9	9
210	R:R:F337	R:R:L227	3.65	Yes	No	0	8	9
211	R:R:H228	R:R:V232	8.3	No	No	0	8	7
212	R:R:H228	R:R:L298	7.71	No	No	0	8	7
213	R:R:H228	R:R:S301	4.18	No	No	0	8	7
214	R:R:T229	R:R:Y244	3.75	No	Yes	0	8	7
215	R:R:R238	R:R:R239	6.4	No	No	0	4	5
216	R:R:C240	R:R:Y244	9.41	No	Yes	0	5	7
217	R:R:F241	R:R:L245	10.96	No	No	0	6	6
218	R:R:C255	R:R:P287	3.77	No	No	0	7	9
219	R:R:R263	R:R:W259	18.99	Yes	Yes	1	7	8
220	R:R:W259	R:R:W272	4.69	Yes	Yes	1	8	8
221	R:R:I284	R:R:W259	7.05	No	Yes	1	7	8
222	R:R:A262	R:R:P280	3.74	No	Yes	0	4	4
223	R:R:E267	R:R:R263	13.96	Yes	Yes	1	5	7
224	R:R:R263	R:R:W272	25.99	Yes	Yes	1	7	8
225	R:R:P280	R:R:R263	4.32	Yes	Yes	1	4	7
226	R:R:D268	R:R:L264	4.07	No	No	1	6	4
227	R:R:L264	R:R:W272	5.69	No	Yes	1	4	8
228	R:R:H277	R:R:L266	11.57	Yes	No	1	5	3
229	R:R:L266	R:R:V279	4.47	No	No	1	3	4
230	R:R:D276	R:R:E267	5.2	No	Yes	1	3	5
231	R:R:E267	R:R:H277	6.15	Yes	Yes	1	5	5
232	R:R:E267	R:R:P280	6.29	Yes	Yes	1	5	4
233	R:R:D268	R:R:W272	7.82	No	Yes	1	6	8
234	R:R:D273	R:R:T274	5.78	Yes	Yes	0	6	5
235	R:R:D276	R:R:T274	4.34	No	Yes	1	3	5
236	R:R:N275	R:R:W281	12.43	No	No	0	6	6
237	R:R:H277	R:R:V279	5.54	Yes	No	1	5	4
238	R:R:H277	R:R:P280	6.1	Yes	Yes	1	5	4
239	R:R:I284	R:R:W281	4.7	No	No	0	7	6
240	R:R:R285	R:R:W282	4	No	No	0	6	6
241	R:R:I292	R:R:Y341	4.84	Yes	Yes	2	7	8
242	R:R:F296	R:R:I300	5.02	No	No	0	6	5
243	R:R:F296	R:R:M342	16.17	No	No	0	6	6
244	R:R:F299	R:R:I303	10.05	Yes	No	3	8	7
245	R:R:F299	R:R:T330	3.89	Yes	No	3	8	9
246	R:R:F299	R:R:L333	4.87	Yes	No	3	8	9
247	R:R:F299	R:R:F337	6.43	Yes	Yes	3	8	8
248	R:R:F299	R:R:V339	5.24	Yes	No	0	8	7
249	R:R:I303	R:R:T330	9.12	No	No	3	7	9
250	R:R:L307	R:R:L326	4.15	No	Yes	0	5	8
251	R:R:L310	R:R:R325	6.07	No	No	0	7	8
252	R:R:K324	R:R:Q322	4.07	No	No	0	6	6
253	R:R:K328	R:R:R325	9.9	No	No	0	8	8
254	R:R:R325	R:R:S329	10.54	No	No	0	8	9
255	R:R:L332	R:R:L374	5.54	No	No	0	8	8
256	R:R:F337	R:R:L333	8.53	Yes	No	3	8	9
257	R:R:I334	R:R:P335	5.08	No	No	0	8	9
258	R:R:I334	R:R:V339	4.61	No	No	0	8	7
259	R:R:L374	R:R:P335	4.93	No	No	0	8	9
260	R:R:F337	R:R:L336	6.09	Yes	Yes	3	8	9
261	R:R:L336	R:R:Y375	21.1	Yes	No	3	9	8
262	R:R:H340	R:R:Y341	11.98	No	Yes	0	9	8
263	R:R:H340	R:R:Q367	8.65	No	No	0	9	9
264	R:R:E360	R:R:Y341	7.86	Yes	Yes	2	7	8
265	R:R:F344	R:R:V343	3.93	Yes	No	0	7	7
266	R:R:F344	R:R:Q356	17.57	Yes	Yes	2	7	7
267	R:R:F344	R:R:F359	6.43	Yes	No	0	7	5
268	R:R:E360	R:R:F344	4.66	Yes	Yes	2	7	7
269	R:R:F347	R:R:P348	8.67	No	No	0	5	7
270	R:R:I351	R:R:Y355	12.09	No	No	0	5	5
271	R:R:K354	R:R:S352	4.59	No	No	0	3	5
272	R:R:E360	R:R:Q356	8.92	Yes	Yes	2	7	7
273	R:R:F359	R:R:L363	3.65	No	No	0	5	6
274	R:R:F377	R:R:V373	3.93	No	No	0	8	6
275	R:R:L374	R:R:Y375	4.69	No	No	0	8	8
276	R:R:C376	R:R:F377	5.59	No	No	0	8	8
277	R:R:N379	R:R:V382	7.39	No	No	0	9	9
278	R:R:E385	R:R:R388	11.63	No	No	0	7	6
279	R:R:K389	R:R:R388	9.9	No	No	0	4	6
280	R:R:R391	R:R:W390	9	No	No	0	5	4
281	R:R:R393	R:R:W390	8	No	No	0	1	4
282	R:R:G257	R:R:T260	3.64	No	No	0	4	5
283	R:R:G270	R:R:T269	3.64	No	No	0	4	4
284	L:L:R12	R:R:N81	3.62	Yes	No	0	0	5
285	R:R:F337	R:R:N295	3.62	Yes	No	0	8	9
286	R:R:P335	R:R:V370	3.53	No	No	0	9	7
287	R:R:I286	R:R:W282	3.52	No	No	0	4	6
288	R:R:P103	R:R:T101	3.5	No	No	0	7	5
289	R:R:G338	R:R:L220	3.42	No	No	0	9	9
290	R:R:G87	R:R:N88	3.39	No	No	0	5	3
291	R:R:I286	R:R:P287	3.39	No	No	0	4	9
292	R:R:K50	R:R:P64	3.35	No	No	0	1	5
293	R:R:D96	R:R:G97	3.35	No	No	0	4	9
294	R:R:N88	R:R:P74	3.26	No	No	0	3	4
295	L:L:G4	L:L:H1	3.18	No	No	0	0	0
296	R:R:T260	R:R:V207	3.17	No	No	0	5	6
297	R:R:P196	R:R:Q195	3.16	No	Yes	0	1	3
298	R:R:A372	R:R:L141	3.15	No	Yes	0	8	9
299	L:L:I5	R:R:S353	3.1	No	No	0	0	4
300	L:L:V26	R:R:I59	3.07	No	No	0	0	6
301	R:R:I89	R:R:V73	3.07	No	No	0	7	6
302	R:R:I247	R:R:V222	3.07	No	No	0	7	8
303	R:R:K179	R:R:S205	3.06	Yes	No	0	6	6
304	R:R:K389	R:R:S392	3.06	No	No	0	4	5
305	R:R:M139	R:R:V136	3.04	No	No	0	4	5
306	R:R:I146	R:R:T143	3.04	No	No	0	4	5
307	R:R:M342	R:R:V346	3.04	No	No	0	6	5
308	R:R:A65	R:R:E69	3.02	No	No	0	7	5
309	R:R:L369	R:R:S137	3	No	No	0	6	9
310	R:R:L163	R:R:S145	3	No	No	0	6	6
311	R:R:L209	R:R:S175	3	No	No	0	6	6
312	R:R:L306	R:R:S329	3	No	No	0	8	9
313	R:R:L132	R:R:V136	2.98	No	No	0	7	5
314	R:R:L221	R:R:V294	2.98	No	No	0	8	7
315	R:R:L298	R:R:V294	2.98	No	No	0	7	7
316	R:R:L307	R:R:T311	2.95	No	No	0	5	5
317	R:R:L326	R:R:T330	2.95	Yes	No	0	8	9
318	R:R:I170	R:R:I174	2.94	Yes	No	0	7	4
319	R:R:D104	R:R:V106	2.92	No	No	0	7	6
320	R:R:I292	R:R:M342	2.92	Yes	No	0	7	6
321	R:R:I129	R:R:L125	2.85	No	No	0	7	4
322	R:R:I305	R:R:L231	2.85	No	No	0	8	8
323	R:R:I293	R:R:L289	2.85	No	No	0	3	5
324	R:R:G270	R:R:W199	2.81	No	Yes	0	4	4
325	R:R:C271	R:R:F27	2.79	No	No	0	9	4
326	R:R:L225	R:R:L298	2.77	No	No	0	7	7
327	R:R:L306	R:R:L326	2.77	No	Yes	0	8	8
328	R:R:L310	R:R:L326	2.77	No	Yes	0	7	8
329	R:R:F366	R:R:V136	2.62	No	No	0	7	5
330	R:R:D194	R:R:E30	2.6	No	No	0	1	5
331	R:R:F151	R:R:I147	2.51	Yes	No	0	7	8
332	R:R:S278	R:R:W282	2.47	No	No	0	5	6
333	L:L:L27	R:R:F105	2.44	No	No	0	0	7
334	R:R:F151	R:R:L154	2.44	Yes	Yes	0	7	8
335	R:R:F151	R:R:L386	2.44	Yes	No	0	7	5
336	R:R:L42	R:R:R43	2.43	No	No	0	5	1
337	R:R:L307	R:R:Y323	2.34	No	No	0	5	6
338	R:R:K203	R:R:W199	2.32	No	Yes	0	7	4
339	R:R:F344	R:R:F347	2.14	Yes	No	0	7	5
340	R:R:R43	R:R:R63	2.13	No	No	0	1	6
341	R:R:F241	R:R:Y160	2.06	No	No	0	6	6
342	R:R:G250	R:R:P252	2.03	No	Yes	0	8	9
343	R:R:C52	R:R:G97	1.96	Yes	No	0	9	9
344	R:R:P236	R:R:P237	1.95	No	No	0	7	5
345	R:R:C240	R:R:P237	1.88	No	No	0	5	5
346	R:R:G188	R:R:S187	1.86	No	No	0	4	3
347	R:R:G68	R:R:V67	1.84	No	No	0	8	6
348	R:R:G144	R:R:T143	1.82	No	No	0	9	5
349	R:R:A51	R:R:C52	1.81	No	Yes	4	4	9
350	R:R:A51	R:R:C93	1.81	No	Yes	4	4	9
351	R:R:A65	R:R:C93	1.81	No	Yes	0	7	9
352	R:R:P348	R:R:S350	1.78	No	No	0	7	4
353	R:R:P74	R:R:V73	1.77	No	No	0	4	6
354	R:R:G364	R:R:L363	1.71	No	No	0	7	6
355	R:R:A51	R:R:V67	1.7	No	No	0	4	6
356	R:R:A258	R:R:V283	1.7	No	No	0	5	8
357	R:R:A233	R:R:T229	1.68	No	No	0	5	8
358	R:R:L235	R:R:P236	1.64	No	No	0	7	7
359	R:R:S53	R:R:V55	1.62	No	No	0	5	6
360	R:R:A142	R:R:I170	1.62	No	Yes	0	3	7
361	R:R:S205	R:R:V178	1.62	No	No	0	6	6
362	R:R:A345	R:R:I292	1.62	No	Yes	0	6	7
363	R:R:D113	R:R:P114	1.61	No	No	0	1	4
364	R:R:S95	R:R:T94	1.6	No	No	0	1	5
365	R:R:S135	R:R:T131	1.6	No	No	0	7	6
366	R:R:V279	R:R:V283	1.6	No	No	0	4	8
367	R:R:C38	R:R:L42	1.59	No	No	0	9	5
368	R:R:A345	R:R:L289	1.58	No	No	0	6	5
369	R:R:T70	R:R:T72	1.57	No	No	0	5	5
370	R:R:I349	R:R:S353	1.55	No	No	0	5	4
371	R:R:I290	R:R:V294	1.54	No	No	0	3	7
372	R:R:K77	R:R:S80	1.53	No	No	0	2	4
373	R:R:K85	R:R:S84	1.53	No	No	0	1	4
374	R:R:C192	R:R:E30	1.52	No	No	0	4	5
375	R:R:I120	R:R:T121	1.52	No	No	0	1	1
376	R:R:L41	R:R:S44	1.5	No	No	0	1	1
377	L:L:L23	L:L:V26	1.49	No	No	0	0	0
378	R:R:L204	R:R:V200	1.49	No	No	0	5	4
379	R:R:L378	R:R:V373	1.49	No	No	0	6	6
380	R:R:L177	R:R:T131	1.47	No	No	0	7	6
381	R:R:D181	R:R:S185	1.47	No	No	0	4	3
382	L:L:A18	R:R:H28	1.46	No	No	0	0	4
383	R:R:N88	R:R:T72	1.46	No	No	0	3	5
384	R:R:I305	R:R:K309	1.45	No	No	0	8	8
385	R:R:Q45	R:R:S44	1.44	No	No	0	1	1
386	R:R:E100	R:R:S99	1.44	No	No	0	3	5
387	R:R:I146	R:R:L150	1.43	No	No	0	4	2
388	R:R:I334	R:R:L331	1.43	No	No	0	8	7
389	R:R:E40	R:R:T36	1.41	No	No	0	4	3
390	R:R:G54	R:R:W62	1.41	No	Yes	0	5	9
391	R:R:G54	R:R:W98	1.41	No	Yes	0	5	8
392	R:R:E34	R:R:I31	1.37	No	No	0	4	6
393	R:R:E33	R:R:K37	1.35	No	No	0	4	3
394	R:R:R393	R:R:S392	1.32	No	No	0	1	5
395	R:R:E47	R:R:Q45	1.27	No	No	0	1	1
396	R:R:V106	R:R:Y111	1.26	No	No	0	6	1
397	R:R:I59	R:R:W56	1.17	No	No	0	6	7
398	R:R:L264	R:R:Y265	1.17	No	No	0	4	3
399	R:R:L266	R:R:Y265	1.17	No	No	0	3	3
400	R:R:Q308	R:R:R304	1.17	No	No	0	7	6
401	R:R:F344	R:R:Y355	1.03	Yes	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:D3	5.476	5	2	0
2	L:L:F6	5.514	5	2	0
3	L:L:R12	8.7475	4	1	0
4	L:L:Y13	9.9825	4	0	0
5	L:L:R14	7.99	5	7	0
6	R:R:Q32	8.6075	4	8	4
7	R:R:C52	7.3325	4	4	9
8	R:R:N58	8.514	5	4	6
9	R:R:W62	7.814	5	4	9
10	R:R:F79	8.87	4	6	5
11	R:R:Y83	9.255	4	6	4
12	R:R:K91	9.39	4	4	8
13	R:R:C93	3.705	4	4	9
14	R:R:W98	7.6425	4	4	8
15	R:R:D116	6.95	5	5	3
16	R:R:Y123	7.554	5	0	5
17	R:R:Y130	7.984	5	2	7
18	R:R:Y134	7.14833	6	2	7
19	R:R:L141	4.948	5	9	9
20	R:R:F151	6.262	5	0	7
21	R:R:L154	4.7875	4	0	8
22	R:R:N159	5.485	4	3	8
23	R:R:H162	6.1525	4	3	9
24	R:R:F169	8.99333	6	9	8
25	R:R:I170	3.28	4	0	7
26	R:R:R172	7.142	5	2	8
27	R:R:K179	6.56	4	0	6
28	R:R:Y184	9.75	5	7	3
29	R:R:Q195	5.585	4	0	3
30	R:R:W199	7.4725	4	0	4
31	R:R:Y211	6.0425	4	0	8
32	R:R:I213	7.645	4	2	5
33	R:R:N216	9.5325	4	0	8
34	R:R:F217	9.5975	4	2	8
35	R:R:F218	7.155	4	0	6
36	R:R:W219	11.966	5	10	9
37	R:R:E223	9.165	4	3	9
38	R:R:Y226	8.95	4	0	7
39	R:R:Y244	6.29	4	0	7
40	R:R:W249	9.6375	4	10	9
41	R:R:P252	4.6525	4	0	9
42	R:R:W259	9.072	5	1	8
43	R:R:R263	15.815	4	1	7
44	R:R:E267	7.9	4	1	5
45	R:R:W272	12.552	5	1	8
46	R:R:D273	7.045	4	0	6
47	R:R:T274	5.2675	4	1	5
48	R:R:H277	7.34	4	1	5
49	R:R:P280	5.1125	4	1	4
50	R:R:I292	3.6	4	2	7
51	R:R:F299	6.096	5	3	8
52	R:R:L326	3.16	4	0	8
53	R:R:L336	10.0825	4	3	9
54	R:R:F337	5.72333	6	3	8
55	R:R:Y341	10.0375	4	2	8
56	R:R:F344	5.96	6	2	7
57	R:R:Q356	8.735	4	2	7
58	R:R:E360	7.875	4	2	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:I213	28.1328	11.93	No	Yes	0	0	5
2	R:R:I213	R:R:R172	30.0661	8.77	Yes	Yes	2	5	8
3	R:R:F217	R:R:R172	22.7915	5.34	Yes	Yes	2	8	8
4	R:R:F217	R:R:Y341	13.3735	15.47	Yes	Yes	2	8	8
5	R:R:E360	R:R:Y341	15.4159	7.86	Yes	Yes	2	7	8
6	R:R:R172	R:R:Y134	46.195	7.2	Yes	Yes	2	8	7
7	L:L:D3	R:R:L361	48.1505	5.43	Yes	No	2	0	7
8	L:L:F6	R:R:L361	47.5708	4.87	Yes	No	2	0	7
9	L:L:F6	R:R:Y123	87.6851	4.13	Yes	Yes	0	0	5
10	R:R:Y130	R:R:Y134	45.2375	6.95	Yes	Yes	2	7	7
11	R:R:I213	R:R:L209	13.1492	4.28	Yes	No	0	5	6
12	R:R:K179	R:R:L209	12.0785	5.64	Yes	No	0	6	6
13	L:L:T7	R:R:K179	10.6927	12.01	No	Yes	0	0	6
14	L:L:T7	R:R:Y184	10.5311	4.99	No	Yes	0	0	3
15	L:L:H1	R:R:Q210	26.9772	8.65	No	No	0	0	7
16	R:R:Q210	R:R:W259	23.044	10.95	No	Yes	1	7	8
17	L:L:Y10	R:R:Y123	22.0056	10.92	No	Yes	0	0	5
18	L:L:Y10	R:R:Y184	10.8765	18.86	No	Yes	7	0	3
19	R:R:D273	R:R:T274	10.8341	5.78	Yes	Yes	0	6	5
20	L:L:Y13	R:R:Y123	87.2972	9.93	Yes	Yes	0	0	5
21	L:L:M17	L:L:Y13	83.2367	15.57	No	Yes	0	0	0
22	L:L:M17	R:R:D116	76.449	4.16	No	Yes	5	0	3
23	L:L:Q16	R:R:D116	69.4733	5.22	No	Yes	5	0	3
24	L:L:Q16	R:R:F82	68.8774	4.68	No	No	0	0	5
25	L:L:V19	R:R:F82	67.1158	10.49	No	No	0	0	5
26	L:L:V19	R:R:F79	66.229	5.24	No	Yes	0	0	5
27	R:R:F79	R:R:V78	61.7341	13.11	Yes	No	0	5	5
28	R:R:E35	R:R:V78	58.9746	9.98	No	No	0	5	5
29	R:R:E35	R:R:Q32	58.0675	3.82	No	Yes	0	5	4
30	R:R:I59	R:R:Q32	54.3201	6.86	No	Yes	0	6	4
31	L:L:V26	R:R:I59	49.5929	3.07	No	No	0	0	6
32	L:L:L27	L:L:V26	47.6859	5.96	No	No	0	0	0
33	R:R:W259	R:R:W272	12.4644	4.69	Yes	Yes	1	8	8
34	R:R:K203	R:R:W272	10.8866	18.57	No	Yes	1	7	8
35	R:R:K203	R:R:W199	10.319	2.32	No	Yes	0	7	4
36	L:L:L27	R:R:F105	46.7081	2.44	No	No	0	0	7
37	R:R:F105	R:R:N58	36.7892	8.46	No	Yes	0	7	6
38	R:R:N58	R:R:W62	13.1028	9.04	Yes	Yes	4	6	9
39	R:R:G54	R:R:W62	10.0584	1.41	No	Yes	0	5	9
40	R:R:K91	R:R:N58	18.4643	6.99	Yes	Yes	4	8	6
41	R:R:K91	R:R:W98	17.6865	6.96	Yes	Yes	4	8	8
42	R:R:F105	R:R:I89	10.1978	10.05	No	No	0	7	7
43	R:R:N216	R:R:R172	100	9.64	Yes	Yes	0	8	8
44	R:R:F169	R:R:N216	66.9421	16.92	Yes	Yes	0	8	8
45	R:R:F169	R:R:L165	62.5705	6.09	Yes	No	0	8	9
46	R:R:E223	R:R:L165	61.9139	11.93	Yes	No	0	9	9
47	R:R:E223	R:R:H162	34.2821	8.62	Yes	Yes	3	9	9
48	R:R:H162	R:R:R158	29.2136	4.51	Yes	No	3	9	9
49	R:R:N159	R:R:R158	27.3853	6.03	Yes	No	3	8	9
50	R:R:L154	R:R:N159	22.949	4.12	Yes	Yes	0	8	8
51	R:R:F151	R:R:L154	19.2804	2.44	Yes	Yes	0	7	8
52	R:R:N216	R:R:S168	34.9245	7.45	Yes	No	0	8	9
53	R:R:S168	R:R:W219	34.1124	7.41	No	Yes	0	9	9
54	R:R:E223	R:R:I161	12.6927	6.83	Yes	No	0	9	9
55	R:R:E223	R:R:L336	28.1631	9.28	Yes	Yes	3	9	9
56	R:R:W219	R:R:W249	20.5349	20.62	Yes	Yes	10	9	9
57	R:R:W249	R:R:Y211	22.8339	7.72	Yes	Yes	0	9	8
58	R:R:P252	R:R:Y211	20.1067	4.17	Yes	Yes	0	9	8
59	R:R:F218	R:R:P252	17.3431	8.67	Yes	Yes	0	6	9
60	R:R:F337	R:R:L336	22.7632	6.09	Yes	Yes	3	8	9
61	R:R:F299	R:R:F337	14.43	6.43	Yes	Yes	3	8	8
62	R:R:L374	R:R:Y375	11.026	4.69	No	No	0	8	8
63	L:L:D3	R:R:R172	40.7325	4.76	Yes	Yes	2	0	8
64	L:L:F6	R:R:Y130	45.2718	8.25	Yes	Yes	2	0	7
65	L:L:R14	L:L:Y10	10.3978	12.35	Yes	No	7	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:Q210	8.65	0	No	No	0	7	0	1
L:L:H1	R:R:I213	11.93	0	No	Yes	0	5	0	1
L:L:S2	R:R:Q356	4.33	2	No	Yes	0	7	0	1
L:L:S2	R:R:E360	10.06	2	No	Yes	0	7	0	1
L:L:D3	R:R:Y134	5.75	2	Yes	Yes	0	7	0	1
L:L:D3	R:R:R172	4.76	2	Yes	Yes	0	8	0	1
L:L:D3	R:R:V176	5.84	2	Yes	No	0	7	0	1
L:L:D3	R:R:I213	5.6	2	Yes	Yes	0	5	0	1
L:L:D3	R:R:L361	5.43	2	Yes	No	0	7	0	1
L:L:I5	R:R:Q356	4.12	0	No	Yes	0	7	0	1
L:L:F6	R:R:Y123	4.13	2	Yes	Yes	0	5	0	1
L:L:F6	R:R:V126	6.55	2	Yes	No	0	6	0	1
L:L:F6	R:R:Y130	8.25	2	Yes	Yes	0	7	0	1
L:L:F6	R:R:I357	3.77	2	Yes	No	0	6	0	1
L:L:F6	R:R:L361	4.87	2	Yes	No	0	7	0	1
L:L:T7	R:R:K179	12.01	0	No	Yes	0	6	0	1
L:L:T7	R:R:Y184	4.99	0	No	Yes	0	3	0	1
L:L:D8	R:R:T274	5.78	1	No	Yes	0	5	0	1
L:L:D8	R:R:N275	5.39	1	No	No	0	6	0	1
L:L:S9	R:R:Y123	7.63	0	No	Yes	0	5	0	1
L:L:Y10	R:R:Y123	10.92	7	No	Yes	0	5	0	1
L:L:Y10	R:R:Y184	18.86	7	No	Yes	0	3	0	1
L:L:S11	R:R:Y184	5.09	0	No	Yes	0	3	0	1
L:L:S11	R:R:D273	8.83	0	No	Yes	0	6	0	1
L:L:R12	R:R:T274	5.17	1	Yes	Yes	0	5	0	1
L:L:R12	R:R:D276	10.72	1	Yes	No	0	3	0	1
L:L:Y13	R:R:K119	5.97	0	Yes	No	0	3	0	1
L:L:Y13	R:R:I120	8.46	0	Yes	No	0	1	0	1
L:L:Y13	R:R:Y123	9.93	0	Yes	Yes	0	5	0	1
L:L:R14	R:R:E24	4.65	7	Yes	No	0	5	0	1
L:L:R14	R:R:C25	8.36	7	Yes	No	0	8	0	1
L:L:R14	R:R:R26	5.33	7	Yes	No	0	4	0	1
L:L:R14	R:R:Y184	9.26	7	Yes	Yes	0	3	0	1
L:L:K15	R:R:F82	13.65	0	No	No	0	5	0	1
L:L:Q16	R:R:F82	4.68	5	No	No	0	5	0	1
L:L:Q16	R:R:D113	5.22	5	No	No	0	1	0	1
L:L:Q16	R:R:D116	5.22	5	No	Yes	0	3	0	1
L:L:M17	R:R:D116	4.16	5	No	Yes	0	3	0	1
L:L:M17	R:R:E117	6.77	5	No	No	0	2	0	1
L:L:V19	R:R:F79	5.24	0	No	Yes	0	5	0	1
L:L:V19	R:R:F82	10.49	0	No	No	0	5	0	1
L:L:K20	R:R:Y111	7.17	5	No	No	0	1	0	1
L:L:K20	R:R:D116	8.3	5	No	Yes	0	3	0	1
L:L:K20	R:R:E117	6.75	5	No	No	0	2	0	1
L:L:Y22	R:R:H28	8.71	8	No	No	0	4	0	1
L:L:Y22	R:R:Q32	10.15	8	No	Yes	0	4	0	1
R:R:E24	R:R:S185	4.31	0	No	No	5	3	1	2
R:R:E24	R:R:L190	15.9	0	No	No	5	1	1	2
R:R:L29	R:R:R26	6.07	0	No	No	4	4	2	1
R:R:C192	R:R:R26	4.18	0	No	No	4	4	2	1
R:R:H28	R:R:Q32	13.6	8	No	Yes	4	4	1	1
R:R:E35	R:R:Q32	3.82	0	No	Yes	5	4	2	1
R:R:I59	R:R:Q32	6.86	0	No	Yes	6	4	1	1
R:R:E35	R:R:V78	9.98	0	No	No	5	5	2	2
R:R:F105	R:R:N58	8.46	0	No	Yes	7	6	1	2
R:R:F79	R:R:P76	5.78	6	Yes	No	5	9	1	2
R:R:P76	R:R:Y83	4.17	6	No	Yes	9	4	2	2
R:R:F79	R:R:V78	13.11	6	Yes	No	5	5	1	2
R:R:F79	R:R:Y83	11.35	6	Yes	Yes	5	4	1	2
R:R:F105	R:R:I89	10.05	0	No	No	7	7	1	2
R:R:D113	R:R:D116	7.98	5	No	Yes	1	3	1	1
R:R:D116	R:R:E117	9.09	5	Yes	No	3	2	1	1
R:R:I120	R:R:I124	5.89	0	No	No	1	1	1	2
R:R:F122	R:R:Y123	5.16	0	No	Yes	4	5	2	1
R:R:F122	R:R:V126	5.24	0	No	No	4	6	2	1
R:R:C362	R:R:V126	5.12	0	No	No	6	6	2	1
R:R:T131	R:R:Y130	3.75	0	No	Yes	6	7	2	1
R:R:Y130	R:R:Y134	6.95	2	Yes	Yes	7	7	1	1
R:R:D180	R:R:Y130	6.9	0	No	Yes	6	7	2	1
R:R:L361	R:R:Y130	14.07	2	No	Yes	7	7	1	1
R:R:R172	R:R:Y134	7.2	2	Yes	Yes	8	7	1	1
R:R:A173	R:R:Y134	4	0	No	Yes	7	7	2	1
R:R:V176	R:R:Y134	11.36	2	No	Yes	7	7	1	1
R:R:S365	R:R:Y134	7.63	0	No	Yes	9	7	2	1
R:R:I213	R:R:R172	8.77	2	Yes	Yes	5	8	1	1
R:R:N216	R:R:R172	9.64	0	Yes	Yes	8	8	2	1
R:R:F217	R:R:R172	5.34	2	Yes	Yes	8	8	2	1
R:R:D180	R:R:K179	5.53	0	No	Yes	6	6	2	1
R:R:K179	R:R:L209	5.64	0	Yes	No	6	6	1	2
R:R:L183	R:R:Y184	10.55	0	No	Yes	6	3	2	1
R:R:D273	R:R:L183	9.5	0	Yes	No	6	6	1	2
R:R:D273	R:R:L206	4.07	0	Yes	No	6	6	1	2
R:R:I213	R:R:L209	4.28	2	Yes	No	5	6	1	2
R:R:Q210	R:R:W259	10.95	1	No	Yes	7	8	1	2
R:R:I284	R:R:Q210	6.86	1	No	No	7	7	2	1
R:R:F217	R:R:Y341	15.47	2	Yes	Yes	8	8	2	2
R:R:I284	R:R:W259	7.05	1	No	Yes	7	8	2	2
R:R:D276	R:R:E267	5.2	1	No	Yes	3	5	1	2
R:R:D273	R:R:T274	5.78	0	Yes	Yes	6	5	1	1
R:R:D276	R:R:T274	4.34	1	No	Yes	3	5	1	1
R:R:N275	R:R:W281	12.43	0	No	No	6	6	1	2
R:R:I284	R:R:W281	4.7	1	No	No	7	6	2	2
R:R:E360	R:R:Y341	7.86	2	Yes	Yes	7	8	1	2
R:R:F344	R:R:Q356	17.57	2	Yes	Yes	7	7	2	1
R:R:E360	R:R:F344	4.66	2	Yes	Yes	7	7	1	2
R:R:E360	R:R:Q356	8.92	2	Yes	Yes	7	7	1	1
L:L:R12	R:R:N81	3.62	1	Yes	No	0	5	0	1
L:L:I5	R:R:S353	3.1	0	No	No	0	4	0	1
L:L:V26	R:R:I59	3.07	0	No	No	0	6	0	1
R:R:K179	R:R:S205	3.06	0	Yes	No	6	6	1	2
L:L:L27	R:R:F105	2.44	0	No	No	0	7	0	1
R:R:D113	R:R:P114	1.61	5	No	No	1	4	1	2
R:R:I349	R:R:S353	1.55	0	No	No	5	4	2	1
R:R:I120	R:R:T121	1.52	0	No	No	1	1	1	2
L:L:A18	R:R:H28	1.46	0	No	No	0	4	0	1
R:R:V106	R:R:Y111	1.26	0	No	No	6	1	2	1
R:R:I59	R:R:W56	1.17	0	No	No	6	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VQX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	363
Number of Links	401
Number of Hubs	58
Number of Links mediated by Hubs	204
Number of Communities	11
Number of Nodes involved in Communities	78
Number of Links involved in Communities	103

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	94798
Length Of Smallest Path	3
Average Path Length	17.7005
Length of Longest Path	42
Minimum Path Strength	1.17
Average Path Strength	7.38974
Maximum Path Strength	22.28
Minimum Path Correlation	0.7
Average Path Correlation	0.956805
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	57.7623
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.9728
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• FnI-like domain • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• FnI-like domain • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41587
Sequence	>7VQX_nogp_Chain_R E C R F H L E I Q E E E T K C A E L L R S Q T E K H K A C S G V W D N I T C W R P A N V G E T V T V P C P K V F S N F Y S K A G N I S K N C T S D G W S E T F P D F V D A C G Y S D P E D E S K I T F Y I L V K A I Y T L G Y S V S L M S L A T G S I I L C L F R K L H C T R N Y I H L N L F L S F I L R A I S V L V K D D V L Y S S S G T L H C P D Q P S S W V G C K L S L V F L Q Y C I M A N F F W L L V E G L Y L H T L L V A M L P P R R C F L A Y L L I G W G L P T V C I G A W T A A R L Y L E D T G C W D T N D H S V P W W V I R I P I L I S I I V N F V L F I S I I R I L L Q K L T S Q Y K R L A K S T L L L I P L F G V H Y M V F A V F P I S I S S K Y Q I L F E L C L G S F Q G L V V A V L Y C F L N S E V Q C E L K R K W R S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7VQX	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.74	2022-05-18	doi.org/10.1038/s41467-022-30041-z
	7VQX (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-		2.74	2022-05-18	doi.org/10.1038/s41467-022-30041-z
	7WBJ	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3.42	2022-05-18	doi.org/10.1038/s41467-022-30041-z
	7WBJ (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-		3.42	2022-05-18	doi.org/10.1038/s41467-022-30041-z

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