psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
2	L:L:H1	R:R:Q210	9.89	Yes	Yes	0	0	7
3	L:L:H1	R:R:I213	7.95	Yes	No	0	0	5
4	L:L:H1	R:R:I288	3.98	Yes	No	0	0	8
5	L:L:S2	R:R:Q356	4.33	No	Yes	0	0	7
6	L:L:S2	R:R:E360	5.75	No	No	0	0	7
7	L:L:S2	R:R:L361	3	No	Yes	0	0	7
8	L:L:D3	R:R:V176	7.3	No	Yes	0	0	7
9	L:L:D3	R:R:L361	5.43	No	Yes	0	0	7
10	L:L:I5	R:R:W281	3.52	No	Yes	0	0	6
11	L:L:I5	R:R:Q356	5.49	No	Yes	0	0	7
12	L:L:F6	R:R:V126	3.93	Yes	No	0	0	6
13	L:L:F6	R:R:Y130	7.22	Yes	Yes	1	0	7
14	L:L:F6	R:R:I357	3.77	Yes	No	0	0	6
15	L:L:F6	R:R:L361	6.09	Yes	Yes	1	0	7
16	L:L:T7	R:R:K179	10.51	No	Yes	1	0	6
17	L:L:T7	R:R:Y184	3.75	No	Yes	1	0	3
18	L:L:T7	R:R:D273	2.89	No	Yes	1	0	6
19	L:L:D8	L:L:R12	4.76	No	No	0	0	0
20	L:L:D8	R:R:T274	5.78	No	Yes	0	0	5
21	L:L:D8	R:R:N275	9.42	No	No	0	0	6
22	L:L:S9	R:R:Y123	8.9	No	Yes	0	0	5
23	L:L:R14	L:L:Y10	11.32	No	No	0	0	0
24	L:L:Y10	R:R:Y123	6.95	No	Yes	0	0	5
25	L:L:Y10	R:R:Y184	16.88	No	Yes	0	0	3
26	L:L:S11	R:R:D273	8.83	No	Yes	1	0	6
27	L:L:S11	R:R:T274	3.2	No	Yes	1	0	5
28	L:L:R12	R:R:N81	4.82	No	Yes	0	0	5
29	L:L:Y13	R:R:D116	4.6	Yes	Yes	0	0	3
30	L:L:Y13	R:R:K119	3.58	Yes	No	7	0	3
31	L:L:Y13	R:R:I120	12.09	Yes	No	0	0	1
32	L:L:Y13	R:R:Y123	9.93	Yes	Yes	7	0	5
33	L:L:M17	L:L:R14	3.72	No	No	0	0	0
34	L:L:Q16	R:R:N81	10.56	No	Yes	0	0	5
35	L:L:K21	L:L:M17	2.88	No	No	0	0	0
36	L:L:V19	R:R:F79	10.49	No	Yes	0	0	5
37	L:L:K20	R:R:Y111	15.53	No	No	0	0	1
38	L:L:K20	R:R:D116	9.68	No	Yes	0	0	3
39	L:L:V26	L:L:Y22	6.31	No	No	3	0	0
40	L:L:Y22	R:R:I59	7.25	No	No	3	0	6
41	L:L:L27	L:L:V26	2.98	No	No	0	0	0
42	L:L:V26	R:R:I59	4.61	No	No	3	0	6
43	R:R:F27	R:R:R26	19.24	No	No	0	4	4
44	R:R:R26	R:R:W199	5	No	No	0	4	4
45	R:R:H28	R:R:L29	6.43	No	No	0	4	4
46	R:R:L29	R:R:Q32	7.99	No	No	0	4	4
47	R:R:C192	R:R:L29	4.76	No	No	0	4	4
48	R:R:E30	R:R:E33	3.81	No	No	0	5	4
49	R:R:E30	R:R:F79	5.83	No	Yes	0	5	5
50	R:R:E34	R:R:I31	5.47	Yes	No	0	4	6
51	R:R:E34	R:R:E35	6.34	Yes	No	3	4	5
52	R:R:E34	R:R:W56	7.63	Yes	Yes	3	4	7
53	R:R:E35	R:R:W56	16.36	No	Yes	3	5	7
54	R:R:C38	R:R:C61	7.28	No	No	0	9	9
55	R:R:L41	R:R:Q45	6.65	No	No	0	1	1
56	R:R:L41	R:R:P64	3.28	No	Yes	0	1	5
57	R:R:L42	R:R:P64	3.28	No	Yes	0	5	5
58	R:R:K50	R:R:P64	3.35	No	Yes	0	1	5
59	R:R:K50	R:R:N66	9.79	No	No	0	1	1
60	R:R:C52	R:R:C93	7.28	Yes	No	2	9	9
61	R:R:C52	R:R:G97	3.92	Yes	No	0	9	9
62	R:R:C52	R:R:W98	14.37	Yes	Yes	2	9	8
63	R:R:S53	R:R:V55	3.23	No	No	0	5	6
64	R:R:G54	R:R:P64	4.06	No	Yes	0	5	5
65	R:R:D57	R:R:V55	5.84	Yes	No	0	9	6
66	R:R:I59	R:R:W56	7.05	No	Yes	3	6	7
67	R:R:D57	R:R:N58	4.04	Yes	Yes	2	9	6
68	R:R:D57	R:R:W62	6.7	Yes	Yes	2	9	9
69	R:R:D57	R:R:K91	8.3	Yes	Yes	2	9	8
70	R:R:D57	R:R:W98	5.58	Yes	Yes	2	9	8
71	R:R:K91	R:R:N58	12.59	Yes	Yes	2	8	6
72	R:R:N58	R:R:T101	7.31	Yes	No	2	6	5
73	R:R:F105	R:R:N58	7.25	No	Yes	0	7	6
74	R:R:T60	R:R:W62	7.28	No	Yes	0	5	9
75	R:R:K91	R:R:W62	13.92	Yes	Yes	2	8	9
76	R:R:W62	R:R:W98	8.43	Yes	Yes	2	9	8
77	R:R:E69	R:R:R63	3.49	No	No	0	5	6
78	R:R:A65	R:R:E69	7.54	No	No	0	7	5
79	R:R:E69	R:R:N66	3.94	No	No	0	5	1
80	R:R:T70	R:R:W98	4.85	No	Yes	0	5	8
81	R:R:N88	R:R:T72	8.77	No	No	0	3	5
82	R:R:S90	R:R:T72	4.8	No	No	0	4	5
83	R:R:N88	R:R:P74	4.89	No	No	0	3	4
84	R:R:C75	R:R:Y83	10.75	No	Yes	0	9	4
85	R:R:C109	R:R:C75	7.28	No	No	0	4	9
86	R:R:P76	R:R:V78	3.53	No	No	8	9	5
87	R:R:F79	R:R:P76	5.78	Yes	No	8	5	9
88	R:R:K77	R:R:S80	6.12	No	No	0	2	4
89	R:R:F79	R:R:V78	5.24	Yes	No	8	5	5
90	R:R:F79	R:R:Y83	5.16	Yes	Yes	0	5	4
91	R:R:N81	R:R:Y83	6.98	Yes	Yes	0	5	4
92	R:R:G110	R:R:K85	3.49	No	No	0	2	1
93	R:R:K85	R:R:S112	6.12	No	No	0	1	4
94	R:R:I89	R:R:P103	3.39	No	No	0	7	7
95	R:R:F105	R:R:I89	7.54	No	No	0	7	7
96	R:R:P103	R:R:S90	3.56	No	No	0	7	4
97	R:R:K91	R:R:W98	8.12	Yes	Yes	2	8	8
98	R:R:K91	R:R:T101	12.01	Yes	No	2	8	5
99	R:R:N92	R:R:S99	8.94	No	No	0	4	5
100	R:R:E100	R:R:N92	11.83	No	No	9	3	4
101	R:R:F102	R:R:N92	7.25	No	No	9	5	4
102	R:R:C93	R:R:W98	5.22	No	Yes	2	9	8
103	R:R:D96	R:R:T94	7.23	No	No	0	4	5
104	R:R:S99	R:R:T94	4.8	No	No	0	5	5
105	R:R:D96	R:R:G97	3.35	No	No	0	4	9
106	R:R:E100	R:R:F102	13.99	No	No	9	3	5
107	R:R:D104	R:R:V106	2.92	No	No	0	7	6
108	R:R:D104	R:R:D107	7.98	No	No	0	7	4
109	R:R:D113	R:R:P114	4.83	No	No	10	1	4
110	R:R:D113	R:R:E115	9.09	No	No	10	1	1
111	R:R:D113	R:R:D116	13.31	No	Yes	0	1	3
112	R:R:E115	R:R:P114	9.43	No	No	10	1	4
113	R:R:K119	R:R:Y123	11.94	No	Yes	7	3	5
114	R:R:F122	R:R:V126	7.87	No	No	0	4	6
115	R:R:F122	R:R:K354	8.69	No	No	0	4	3
116	R:R:C362	R:R:I129	4.91	No	No	0	6	7
117	R:R:V176	R:R:Y130	5.05	Yes	Yes	1	7	7
118	R:R:L361	R:R:Y130	4.69	Yes	Yes	1	7	7
119	R:R:L177	R:R:T131	2.95	No	No	0	7	6
120	R:R:L132	R:R:S135	3	No	No	0	7	7
121	R:R:F366	R:R:G133	3.01	No	No	0	7	9
122	R:R:R172	R:R:Y134	4.12	Yes	Yes	0	8	7
123	R:R:V176	R:R:Y134	7.57	Yes	Yes	0	7	7
124	R:R:L177	R:R:Y134	3.52	No	Yes	0	7	7
125	R:R:S365	R:R:Y134	5.09	No	Yes	0	9	7
126	R:R:L369	R:R:V136	7.45	No	No	0	6	5
127	R:R:G368	R:R:S137	3.71	No	No	0	9	9
128	R:R:I170	R:R:L138	4.28	Yes	No	0	7	6
129	R:R:A173	R:R:L138	4.73	No	No	0	7	6
130	R:R:L369	R:R:S140	3	No	No	0	6	7
131	R:R:F166	R:R:L141	3.65	Yes	Yes	0	8	9
132	R:R:F169	R:R:L141	3.65	Yes	Yes	0	8	9
133	R:R:I170	R:R:L141	4.28	Yes	Yes	0	7	9
134	R:R:A372	R:R:L141	3.15	No	Yes	0	8	9
135	R:R:G144	R:R:T143	3.64	No	No	0	9	5
136	R:R:F166	R:R:G144	3.01	Yes	No	6	8	9
137	R:R:C376	R:R:G144	3.92	Yes	No	6	8	9
138	R:R:I170	R:R:S145	3.1	Yes	No	0	7	6
139	R:R:I146	R:R:I147	2.94	No	No	0	4	8
140	R:R:C376	R:R:I147	3.27	Yes	No	0	8	8
141	R:R:L148	R:R:N159	4.12	Yes	No	0	7	8
142	R:R:F166	R:R:L148	3.65	Yes	Yes	6	8	7
143	R:R:C376	R:R:L148	3.17	Yes	Yes	6	8	7
144	R:R:F151	R:R:L154	4.87	No	No	0	7	8
145	R:R:E385	R:R:F151	12.83	Yes	No	0	7	7
146	R:R:H155	R:R:R152	3.39	No	No	0	8	8
147	R:R:L154	R:R:N159	5.49	No	No	0	8	8
148	R:R:H155	R:R:Y160	14.16	No	No	0	8	6
149	R:R:C156	R:R:N159	4.72	No	No	0	8	8
150	R:R:T157	R:R:Y226	9.99	No	Yes	0	7	7
151	R:R:H162	R:R:R158	3.39	No	No	0	9	9
152	R:R:R158	R:R:Y226	3.09	No	Yes	0	9	7
153	R:R:F241	R:R:Y160	6.19	No	No	0	6	6
154	R:R:I161	R:R:W219	3.52	Yes	Yes	0	9	9
155	R:R:E223	R:R:I161	4.1	No	Yes	0	9	9
156	R:R:I161	R:R:Y244	3.63	Yes	Yes	0	9	7
157	R:R:E223	R:R:H162	9.85	No	No	0	9	9
158	R:R:H162	R:R:Y375	4.36	No	No	0	9	8
159	R:R:N164	R:R:W219	16.95	No	Yes	11	8	9
160	R:R:L245	R:R:N164	5.49	No	No	0	6	8
161	R:R:N164	R:R:W249	3.39	No	No	11	8	9
162	R:R:F169	R:R:L165	4.87	Yes	No	0	8	9
163	R:R:L165	R:R:L220	5.54	No	No	0	9	9
164	R:R:F166	R:R:V371	3.93	Yes	No	0	8	9
165	R:R:C376	R:R:F166	4.19	Yes	Yes	6	8	8
166	R:R:N216	R:R:S168	4.47	Yes	No	0	8	9
167	R:R:S168	R:R:W219	7.41	No	Yes	0	9	9
168	R:R:F169	R:R:N216	9.67	Yes	Yes	0	8	8
169	R:R:F169	R:R:G368	3.01	Yes	No	0	8	9
170	R:R:F169	R:R:V371	5.24	Yes	No	0	8	9
171	R:R:I170	R:R:I174	2.94	Yes	No	0	7	4
172	R:R:C212	R:R:L171	7.94	No	No	0	6	7
173	R:R:I213	R:R:R172	6.26	No	Yes	0	5	8
174	R:R:N216	R:R:R172	12.05	Yes	Yes	5	8	8
175	R:R:F217	R:R:R172	4.28	Yes	Yes	5	8	8
176	R:R:R172	R:R:Y341	3.09	Yes	Yes	5	8	8
177	R:R:S175	R:R:V176	3.23	Yes	Yes	1	6	7
178	R:R:F208	R:R:S175	5.28	No	Yes	1	6	6
179	R:R:L209	R:R:S175	6.01	Yes	Yes	1	6	6
180	R:R:C212	R:R:S175	6.89	No	Yes	1	6	6
181	R:R:L209	R:R:V176	4.47	Yes	Yes	1	6	7
182	R:R:S205	R:R:V178	4.85	No	No	0	6	6
183	R:R:K179	R:R:L183	4.23	Yes	Yes	1	6	6
184	R:R:K179	R:R:Y184	4.78	Yes	Yes	1	6	3
185	R:R:K179	R:R:L209	5.64	Yes	Yes	1	6	6
186	R:R:D180	R:R:D181	5.32	No	No	0	6	4
187	R:R:L183	R:R:V182	2.98	Yes	No	0	6	5
188	R:R:C202	R:R:V182	3.42	No	No	0	9	5
189	R:R:S205	R:R:V182	6.46	No	No	0	6	5
190	R:R:L183	R:R:Y184	9.38	Yes	Yes	1	6	3
191	R:R:D273	R:R:L183	4.07	Yes	Yes	1	6	6
192	R:R:H191	R:R:T189	9.58	No	No	0	3	1
193	R:R:H191	R:R:P193	9.15	No	No	0	3	3
194	R:R:P193	R:R:Q195	9.47	No	Yes	0	3	3
195	R:R:Q195	R:R:S197	7.22	Yes	No	0	3	3
196	R:R:Q195	R:R:S198	8.66	Yes	No	0	3	6
197	R:R:S198	R:R:W199	3.71	No	No	0	6	4
198	R:R:K203	R:R:W199	4.64	No	No	0	7	4
199	R:R:C202	R:R:C271	7.28	No	No	0	9	9
200	R:R:K203	R:R:W272	12.76	No	Yes	0	7	8
201	R:R:T260	R:R:V207	3.17	No	No	0	5	6
202	R:R:C212	R:R:F208	8.38	No	No	1	6	6
203	R:R:L209	R:R:Q210	5.32	Yes	Yes	1	6	7
204	R:R:Q210	R:R:W259	6.57	Yes	Yes	1	7	8
205	R:R:I284	R:R:Q210	6.86	Yes	Yes	1	7	7
206	R:R:W249	R:R:Y211	7.72	No	Yes	0	9	8
207	R:R:P252	R:R:Y211	4.17	Yes	Yes	0	9	8
208	R:R:T253	R:R:Y211	6.24	No	Yes	0	5	8
209	R:R:I256	R:R:Y211	4.84	No	Yes	0	7	8
210	R:R:M214	R:R:P252	3.35	Yes	Yes	0	6	9
211	R:R:I284	R:R:M214	2.92	Yes	Yes	0	7	6
212	R:R:I288	R:R:M214	5.83	No	Yes	0	8	6
213	R:R:A215	R:R:P252	3.74	No	Yes	0	8	9
214	R:R:F217	R:R:N216	3.62	Yes	Yes	5	8	8
215	R:R:F217	R:R:I288	10.05	Yes	No	0	8	8
216	R:R:F217	R:R:Y341	13.41	Yes	Yes	5	8	8
217	R:R:F218	R:R:L251	9.74	No	No	12	6	4
218	R:R:F218	R:R:P252	5.78	No	Yes	12	6	9
219	R:R:F218	R:R:S291	3.96	No	No	0	6	8
220	R:R:V222	R:R:W219	3.68	No	Yes	0	8	9
221	R:R:G248	R:R:W219	9.85	No	Yes	0	9	9
222	R:R:W219	R:R:W249	19.68	Yes	No	11	9	9
223	R:R:L221	R:R:S291	4.5	No	No	0	8	8
224	R:R:L221	R:R:V294	2.98	No	No	0	8	7
225	R:R:I247	R:R:V222	3.07	No	No	0	7	8
226	R:R:E223	R:R:L336	11.93	No	No	0	9	9
227	R:R:F337	R:R:G224	4.52	Yes	No	0	8	9
228	R:R:L225	R:R:Y244	4.69	No	Yes	0	7	7
229	R:R:L230	R:R:Y226	14.07	No	Yes	0	7	7
230	R:R:Y226	R:R:Y244	2.98	Yes	Yes	0	7	7
231	R:R:I302	R:R:L227	11.42	Yes	No	4	9	9
232	R:R:F337	R:R:L227	3.65	Yes	No	4	8	9
233	R:R:H228	R:R:V232	4.15	Yes	No	0	8	7
234	R:R:H228	R:R:L298	5.14	Yes	No	0	8	7
235	R:R:H228	R:R:S301	6.97	Yes	No	0	8	7
236	R:R:T229	R:R:Y244	3.75	No	Yes	0	8	7
237	R:R:I305	R:R:L231	4.28	No	No	0	8	8
238	R:R:L235	R:R:M234	4.24	No	No	0	7	7
239	R:R:C240	R:R:P237	5.65	No	No	0	5	5
240	R:R:R238	R:R:R239	8.53	No	No	0	4	5
241	R:R:G250	R:R:T253	3.64	No	No	0	8	5
242	R:R:L251	R:R:P252	3.28	No	Yes	12	4	9
243	R:R:C255	R:R:P287	3.77	No	No	0	7	9
244	R:R:R263	R:R:W259	8	Yes	Yes	0	7	8
245	R:R:V283	R:R:W259	3.68	No	Yes	0	8	8
246	R:R:I284	R:R:W259	3.52	Yes	Yes	1	7	8
247	R:R:L264	R:R:T260	2.95	No	No	0	4	5
248	R:R:R263	R:R:W272	39.98	Yes	Yes	0	7	8
249	R:R:P280	R:R:R263	4.32	No	Yes	0	4	7
250	R:R:E267	R:R:L266	7.95	No	No	0	5	3
251	R:R:L266	R:R:V279	5.96	No	No	0	3	4
252	R:R:E267	R:R:H277	18.46	No	Yes	0	5	5
253	R:R:D268	R:R:W272	3.35	No	Yes	0	6	8
254	R:R:G270	R:R:T269	3.64	No	No	0	4	4
255	R:R:T269	R:R:W272	6.06	No	Yes	0	4	8
256	R:R:D273	R:R:T274	4.34	Yes	Yes	1	6	5
257	R:R:D276	R:R:T274	5.78	No	Yes	0	3	5
258	R:R:N275	R:R:W281	13.56	No	Yes	0	6	6
259	R:R:H277	R:R:V279	5.54	Yes	No	13	5	4
260	R:R:H277	R:R:P280	6.1	Yes	No	13	5	4
261	R:R:P280	R:R:V279	5.3	No	No	13	4	4
262	R:R:I284	R:R:W281	3.52	Yes	Yes	0	7	6
263	R:R:R285	R:R:W281	12	No	Yes	0	6	6
264	R:R:I286	R:R:P287	3.39	No	No	0	4	9
265	R:R:I286	R:R:I290	2.94	No	No	0	4	3
266	R:R:I292	R:R:Y341	4.84	No	Yes	0	7	8
267	R:R:I292	R:R:M342	2.92	No	No	0	7	6
268	R:R:F337	R:R:N295	14.5	Yes	No	0	8	9
269	R:R:F296	R:R:I300	5.02	No	No	0	6	5
270	R:R:F296	R:R:M342	7.46	No	No	0	6	6
271	R:R:I300	R:R:V297	3.07	No	No	0	5	4
272	R:R:F299	R:R:I303	7.54	Yes	No	0	8	7
273	R:R:F299	R:R:L333	4.87	Yes	No	4	8	9
274	R:R:F299	R:R:F337	7.5	Yes	Yes	4	8	8
275	R:R:F299	R:R:V339	3.93	Yes	No	0	8	7
276	R:R:F337	R:R:I302	3.77	Yes	Yes	4	8	9
277	R:R:I303	R:R:T330	3.04	No	No	0	7	9
278	R:R:L306	R:R:S329	3	No	No	0	8	9
279	R:R:K309	R:R:Q308	5.42	No	No	0	8	7
280	R:R:K324	R:R:Q322	5.42	No	No	0	6	6
281	R:R:L326	R:R:T330	2.95	Yes	No	0	8	9
282	R:R:I334	R:R:T330	3.04	Yes	No	0	8	9
283	R:R:L332	R:R:L374	6.92	No	No	0	8	8
284	R:R:F337	R:R:L333	8.53	Yes	No	4	8	9
285	R:R:I334	R:R:P335	3.39	Yes	No	0	8	9
286	R:R:I334	R:R:V339	4.61	Yes	No	0	8	7
287	R:R:L336	R:R:Y375	18.76	No	No	0	9	8
288	R:R:G338	R:R:Y341	2.9	No	Yes	0	9	8
289	R:R:H340	R:R:Q367	8.65	No	No	0	9	9
290	R:R:E360	R:R:Y341	6.73	No	Yes	0	7	8
291	R:R:Q367	R:R:Y341	14.65	No	Yes	0	9	8
292	R:R:M342	R:R:V346	3.04	No	No	0	6	5
293	R:R:F344	R:R:V343	3.93	No	No	14	7	7
294	R:R:F359	R:R:V343	5.24	No	No	14	5	7
295	R:R:F344	R:R:Q356	3.51	No	Yes	0	7	7
296	R:R:F344	R:R:F359	8.57	No	No	14	7	5
297	R:R:F347	R:R:P348	10.11	No	No	0	5	7
298	R:R:F347	R:R:I351	3.77	No	No	0	5	5
299	R:R:S352	R:R:Y355	6.36	No	No	0	5	5
300	R:R:I357	R:R:Q356	5.49	No	Yes	0	6	7
301	R:R:C362	R:R:L358	3.17	No	No	0	6	6
302	R:R:E360	R:R:F359	11.66	No	No	0	7	5
303	R:R:G364	R:R:L363	3.42	No	No	0	7	6
304	R:R:F366	R:R:L369	6.09	No	No	0	7	6
305	R:R:L374	R:R:V373	4.47	No	No	0	8	6
306	R:R:L374	R:R:Y375	8.21	No	No	0	8	8
307	R:R:E381	R:R:N379	6.57	No	No	0	9	9
308	R:R:N379	R:R:V382	5.91	No	No	0	9	9
309	R:R:E381	R:R:S380	10.06	No	No	0	9	5
310	R:R:E385	R:R:L386	5.3	Yes	No	0	7	5
311	R:R:K389	R:R:R388	7.43	No	No	0	4	6
312	R:R:R391	R:R:W390	13	No	No	0	5	4
313	R:R:E385	R:R:V382	2.85	Yes	No	0	7	9
314	R:R:C192	R:R:F27	2.79	No	No	0	4	4
315	R:R:L148	R:R:L163	2.77	Yes	No	0	7	6
316	R:R:L167	R:R:L171	2.77	No	No	0	4	7
317	R:R:L183	R:R:L206	2.77	Yes	No	0	6	6
318	R:R:L306	R:R:L310	2.77	No	No	0	8	7
319	R:R:I305	R:R:Q308	2.74	No	No	0	8	7
320	R:R:I349	R:R:Q356	2.74	No	Yes	0	5	7
321	R:R:E30	R:R:I31	2.73	No	No	0	5	6
322	R:R:D180	R:R:L177	2.71	No	No	0	6	7
323	R:R:E385	R:R:K153	2.7	Yes	No	0	7	6
324	R:R:E385	R:R:K389	2.7	Yes	No	0	7	4
325	R:R:H228	R:R:I302	2.65	Yes	Yes	0	8	9
326	R:R:H340	R:R:I334	2.65	No	Yes	0	9	8
327	R:R:F377	R:R:V373	2.62	No	No	0	8	6
328	R:R:C61	R:R:W56	2.61	No	Yes	0	9	7
329	R:R:R263	R:R:T260	2.59	Yes	No	0	7	5
330	R:R:F241	R:R:I161	2.51	No	Yes	0	6	9
331	R:R:F27	R:R:L190	2.44	No	No	0	4	1
332	R:R:F122	R:R:L358	2.44	No	No	0	4	6
333	R:R:F151	R:R:L150	2.44	No	No	0	7	2
334	R:R:D104	R:R:F105	2.39	No	No	0	7	7
335	R:R:K127	R:R:Y130	2.39	No	Yes	0	5	7
336	R:R:A108	R:R:G87	1.95	No	No	0	9	5
337	R:R:P236	R:R:P237	1.95	No	No	0	7	5
338	R:R:A108	R:R:P103	1.87	No	No	0	9	7
339	R:R:G68	R:R:V67	1.84	No	No	0	8	6
340	R:R:G110	R:R:V106	1.84	No	No	0	2	6
341	R:R:A51	R:R:C52	1.81	No	Yes	2	4	9
342	R:R:A51	R:R:C93	1.81	No	No	2	4	9
343	R:R:P348	R:R:S350	1.78	No	No	0	7	4
344	R:R:P74	R:R:V73	1.77	No	No	0	4	6
345	R:R:P335	R:R:V370	1.77	No	No	0	9	7
346	R:R:G201	R:R:L204	1.71	No	No	0	3	5
347	R:R:A51	R:R:V67	1.7	No	No	0	4	6
348	R:R:A258	R:R:V283	1.7	No	No	0	5	8
349	R:R:M214	R:R:P287	1.68	Yes	No	0	6	9
350	R:R:A233	R:R:T229	1.68	No	No	0	5	8
351	R:R:L230	R:R:P236	1.64	No	No	0	7	7
352	R:R:L235	R:R:P236	1.64	No	No	0	7	7
353	R:R:S135	R:R:V136	1.62	No	No	0	7	5
354	L:L:A18	L:L:M17	1.61	No	No	0	0	0
355	R:R:V71	R:R:V73	1.6	No	No	0	7	6
356	R:R:S118	R:R:T121	1.6	No	No	0	1	1
357	R:R:S312	R:R:T311	1.6	No	No	0	6	5
358	R:R:C149	R:R:L163	1.59	No	No	0	3	6
359	R:R:P196	R:R:Q195	1.58	No	Yes	0	1	3
360	R:R:I351	R:R:S352	1.55	No	No	0	5	5
361	R:R:I293	R:R:V346	1.54	No	No	0	3	5
362	R:R:K354	R:R:S352	1.53	No	No	0	3	5
363	R:R:K389	R:R:S392	1.53	No	No	0	4	5
364	R:R:I120	R:R:T121	1.52	No	No	0	1	1
365	R:R:L42	R:R:S53	1.5	No	No	0	5	5
366	R:R:L141	R:R:S140	1.5	Yes	No	0	9	7
367	L:L:L23	L:L:V19	1.49	No	No	0	0	0
368	R:R:L378	R:R:V373	1.49	No	No	0	6	6
369	R:R:D96	R:R:S95	1.47	No	No	0	4	1
370	R:R:G110	R:R:Y83	1.45	No	Yes	0	2	4
371	R:R:I124	R:R:K127	1.45	No	No	0	1	5
372	R:R:Q45	R:R:S44	1.44	No	No	0	1	1
373	R:R:K48	R:R:K50	1.44	No	No	0	1	1
374	R:R:P237	R:R:R239	1.44	No	No	0	5	5
375	R:R:I124	R:R:L125	1.43	No	No	0	1	4
376	R:R:I302	R:R:L231	1.43	Yes	No	0	9	8
377	R:R:I293	R:R:L289	1.43	No	No	0	3	5
378	R:R:Q383	R:R:V382	1.43	No	No	0	8	9
379	R:R:E33	R:R:T36	1.41	No	No	0	4	3
380	R:R:H277	R:R:S278	1.39	Yes	No	0	5	5
381	R:R:L306	R:R:L326	1.38	No	Yes	0	8	8
382	R:R:L307	R:R:L326	1.38	No	Yes	0	5	8
383	R:R:K387	R:R:Q383	1.36	No	No	0	5	8
384	R:R:E34	R:R:K37	1.35	Yes	No	0	4	3
385	R:R:A261	R:R:Y265	1.33	No	No	0	4	3
386	L:L:R14	R:R:S186	1.32	No	No	0	0	3
387	R:R:R393	R:R:S392	1.32	No	No	0	1	5
388	R:R:D116	R:R:E117	1.3	Yes	No	0	3	2
389	R:R:I305	R:R:R304	1.25	No	No	0	8	6
390	R:R:L42	R:R:R43	1.21	No	No	0	5	1
391	R:R:F82	R:R:N81	1.21	No	Yes	0	5	5
392	R:R:L310	R:R:R325	1.21	No	No	0	7	8
393	R:R:L326	R:R:Y323	1.17	Yes	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	6.25	4	0	0
2	L:L:F6	5.2525	4	1	0
3	L:L:Y13	7.55	4	7	0
4	R:R:E34	5.1975	4	3	4
5	R:R:C52	6.845	4	2	9
6	R:R:W56	8.4125	4	3	7
7	R:R:D57	6.092	5	2	9
8	R:R:N58	7.7975	4	2	6
9	R:R:W62	9.0825	4	2	9
10	R:R:P64	3.4925	4	0	5
11	R:R:F79	6.5	5	8	5
12	R:R:N81	5.8925	4	0	5
13	R:R:Y83	6.085	4	0	4
14	R:R:K91	10.988	5	2	8
15	R:R:W98	7.76167	6	2	8
16	R:R:D116	7.2225	4	0	3
17	R:R:Y123	9.43	4	7	5
18	R:R:Y130	4.8375	4	1	7
19	R:R:Y134	5.075	4	0	7
20	R:R:L141	3.246	5	0	9
21	R:R:L148	3.4275	4	6	7
22	R:R:I161	3.44	4	0	9
23	R:R:F166	3.686	5	6	8
24	R:R:F169	5.288	5	0	8
25	R:R:I170	3.65	4	0	7
26	R:R:R172	5.96	5	5	8
27	R:R:S175	5.3525	4	1	6
28	R:R:V176	5.524	5	1	7
29	R:R:K179	6.29	4	1	6
30	R:R:L183	4.686	5	1	6
31	R:R:Y184	8.6975	4	1	3
32	R:R:Q195	6.7325	4	0	3
33	R:R:L209	5.36	4	1	6
34	R:R:Q210	7.16	4	1	7
35	R:R:Y211	5.7425	4	0	8
36	R:R:M214	3.445	4	0	6
37	R:R:N216	7.4525	4	5	8
38	R:R:F217	7.84	4	5	8
39	R:R:W219	10.1817	6	11	9
40	R:R:Y226	7.5325	4	0	7
41	R:R:H228	4.7275	4	0	8
42	R:R:Y244	3.7625	4	0	7
43	R:R:P252	4.064	5	12	9
44	R:R:W259	5.4425	4	1	8
45	R:R:R263	13.7225	4	0	7
46	R:R:W272	15.5375	4	0	8
47	R:R:D273	5.0325	4	1	6
48	R:R:T274	4.775	4	1	5
49	R:R:H277	7.8725	4	13	5
50	R:R:W281	8.15	4	0	6
51	R:R:I284	4.205	4	1	7
52	R:R:F299	5.96	4	4	8
53	R:R:I302	4.8175	4	4	9
54	R:R:L326	1.72	4	0	8
55	R:R:I334	3.4225	4	0	8
56	R:R:F337	7.07833	6	4	8
57	R:R:Y341	7.60333	6	5	8
58	R:R:Q356	4.312	5	0	7
59	R:R:L361	4.8025	4	1	7
60	R:R:C376	3.6375	4	6	8
61	R:R:E385	5.276	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:Q210	21.8684	9.89	Yes	Yes	0	0	7
2	L:L:H1	R:R:I213	11.4916	7.95	Yes	No	0	0	5
3	L:L:H1	R:R:I288	11.1499	3.98	Yes	No	0	0	8
4	R:R:I213	R:R:R172	11.4843	6.26	No	Yes	0	5	8
5	R:R:R172	R:R:Y341	24.4638	3.09	Yes	Yes	5	8	8
6	R:R:E360	R:R:Y341	20.0945	6.73	No	Yes	0	7	8
7	L:L:S2	R:R:E360	17.6324	5.75	No	No	0	0	7
8	R:R:F217	R:R:I288	56.6461	10.05	Yes	No	0	8	8
9	R:R:F217	R:R:Y341	34.5402	13.41	Yes	Yes	5	8	8
10	R:R:I284	R:R:W281	64.3524	3.52	Yes	Yes	0	7	6
11	L:L:I5	R:R:W281	21.5655	3.52	No	Yes	0	0	6
12	L:L:I5	R:R:Q356	21.3644	5.49	No	Yes	0	0	7
13	R:R:L209	R:R:Q210	14.0628	5.32	Yes	Yes	1	6	7
14	R:R:L209	R:R:V176	31.5255	4.47	Yes	Yes	1	6	7
15	R:R:V176	R:R:Y130	14.9691	5.05	Yes	Yes	1	7	7
16	L:L:F6	R:R:V126	12.0078	3.93	Yes	No	0	0	6
17	R:R:K179	R:R:L209	33.5102	5.64	Yes	Yes	1	6	6
18	R:R:K179	R:R:Y184	14.5014	4.78	Yes	Yes	1	6	3
19	L:L:T7	R:R:D273	12.4827	2.89	No	Yes	1	0	6
20	R:R:K179	R:R:L183	11.5425	4.23	Yes	Yes	1	6	6
21	R:R:D273	R:R:L183	14.1549	4.07	Yes	Yes	1	6	6
22	L:L:D8	R:R:N275	79.7383	9.42	No	No	0	0	6
23	R:R:N275	R:R:W281	80.1091	13.56	No	Yes	0	6	6
24	L:L:D8	L:L:R12	100	4.76	No	No	0	0	0
25	R:R:D273	R:R:T274	24.3112	4.34	Yes	Yes	1	6	5
26	L:L:D8	R:R:T274	24.9315	5.78	No	Yes	0	0	5
27	L:L:Y10	R:R:Y184	24.7159	16.88	No	Yes	0	0	3
28	L:L:Y10	R:R:Y123	17.5039	6.95	No	Yes	0	0	5
29	L:L:R12	R:R:N81	99.2633	4.82	No	Yes	0	0	5
30	L:L:Y13	R:R:Y123	13.8059	9.93	Yes	Yes	7	0	5
31	R:R:N81	R:R:Y83	97.0241	6.98	Yes	Yes	0	5	4
32	R:R:F79	R:R:Y83	22.3652	5.16	Yes	Yes	0	5	4
33	R:R:E30	R:R:F79	16.6218	5.83	No	Yes	0	5	5
34	R:R:E30	R:R:I31	13.1177	2.73	No	No	0	5	6
35	R:R:E34	R:R:I31	11.9399	5.47	Yes	No	0	4	6
36	R:R:Q210	R:R:W259	24.7886	6.57	Yes	Yes	1	7	8
37	R:R:R263	R:R:W259	44.4178	8	Yes	Yes	0	7	8
38	R:R:R263	R:R:W272	30.0957	39.98	Yes	Yes	0	7	8
39	R:R:K203	R:R:W272	24.2312	12.76	No	Yes	0	7	8
40	R:R:K203	R:R:W199	22.7529	4.64	No	No	0	7	4
41	R:R:R26	R:R:W199	10.7525	5	No	No	0	4	4
42	R:R:G110	R:R:Y83	79.3287	1.45	No	Yes	0	2	4
43	R:R:G110	R:R:V106	76.726	1.84	No	No	0	2	6
44	R:R:D104	R:R:V106	75.8488	2.92	No	No	0	7	6
45	R:R:D104	R:R:F105	74.0797	2.39	No	No	0	7	7
46	R:R:F105	R:R:N58	63.9937	7.25	No	Yes	0	7	6
47	R:R:D57	R:R:N58	39.193	4.04	Yes	Yes	2	9	6
48	R:R:D57	R:R:V55	17.1913	5.84	Yes	No	0	9	6
49	R:R:S53	R:R:V55	16.079	3.23	No	No	0	5	6
50	R:R:L42	R:R:S53	14.9618	1.5	No	No	0	5	5
51	R:R:L42	R:R:P64	12.713	3.28	No	Yes	0	5	5
52	R:R:D57	R:R:W98	20.2738	5.58	Yes	Yes	2	9	8
53	R:R:C52	R:R:W98	26.7515	14.37	Yes	Yes	2	9	8
54	R:R:K91	R:R:N58	22.8305	12.59	Yes	Yes	2	8	6
55	R:R:K91	R:R:W98	19.6704	8.12	Yes	Yes	2	8	8
56	R:R:C52	R:R:G97	17.9305	3.92	Yes	No	0	9	9
57	R:R:F105	R:R:I89	12.0417	7.54	No	No	0	7	7
58	R:R:I89	R:R:P103	10.8591	3.39	No	No	0	7	7
59	R:R:D96	R:R:G97	15.7058	3.35	No	No	0	4	9
60	R:R:D96	R:R:T94	11.242	7.23	No	No	0	4	5
61	R:R:F122	R:R:V126	11.0336	7.87	No	No	0	4	6
62	R:R:R172	R:R:Y134	26.9938	4.12	Yes	Yes	0	8	7
63	R:R:N216	R:R:R172	42.4064	12.05	Yes	Yes	5	8	8
64	R:R:F169	R:R:N216	81.3232	9.67	Yes	Yes	0	8	8
65	R:R:F169	R:R:L141	45.5907	3.65	Yes	Yes	0	8	9
66	R:R:F217	R:R:N216	50.5586	3.62	Yes	Yes	5	8	8
67	R:R:F166	R:R:L141	30.9342	3.65	Yes	Yes	0	8	9
68	R:R:F169	R:R:V371	31.1305	5.24	Yes	No	0	8	9
69	R:R:F166	R:R:V371	30.0909	3.93	Yes	No	0	8	9
70	R:R:F166	R:R:L148	47.5633	3.65	Yes	Yes	6	8	7
71	R:R:L148	R:R:N159	41.1366	4.12	Yes	No	0	7	8
72	R:R:L154	R:R:N159	36.6388	5.49	No	No	0	8	8
73	R:R:F151	R:R:L154	34.3826	4.87	No	No	0	7	8
74	R:R:E385	R:R:F151	29.8558	12.83	Yes	No	0	7	7
75	R:R:N216	R:R:S168	28.1086	4.47	Yes	No	0	8	9
76	R:R:S168	R:R:W219	27.0932	7.41	No	Yes	0	9	9
77	R:R:I161	R:R:W219	36.7188	3.52	Yes	Yes	0	9	9
78	R:R:I161	R:R:Y244	15.684	3.63	Yes	Yes	0	9	7
79	R:R:Y226	R:R:Y244	11.6031	2.98	Yes	Yes	0	7	7
80	R:R:E223	R:R:I161	16.6994	4.1	No	Yes	0	9	9
81	R:R:I288	R:R:M214	45.8863	5.83	No	Yes	0	8	6
82	R:R:M214	R:R:P252	24.8443	3.35	Yes	Yes	0	6	9
83	R:R:P252	R:R:Y211	19.5008	4.17	Yes	Yes	0	9	8
84	R:R:W249	R:R:Y211	17.8626	7.72	No	Yes	0	9	8
85	R:R:S198	R:R:W199	10.7525	3.71	No	No	0	6	4
86	R:R:Q367	R:R:Y341	50.5949	14.65	No	Yes	0	9	8
87	R:R:H340	R:R:Q367	49.0706	8.65	No	No	0	9	9
88	R:R:H340	R:R:I334	47.5051	2.65	No	Yes	0	9	8
89	R:R:I334	R:R:V339	27.9898	4.61	Yes	No	0	8	7
90	R:R:F299	R:R:V339	26.3662	3.93	Yes	No	0	8	7
91	R:R:F299	R:R:F337	23.4072	7.5	Yes	Yes	4	8	8
92	R:R:F337	R:R:I302	16.8157	3.77	Yes	Yes	4	8	9
93	R:R:I292	R:R:Y341	13.5102	4.84	No	Yes	0	7	8
94	R:R:I292	R:R:M342	11.8381	2.92	No	No	0	7	6
95	R:R:I334	R:R:T330	14.8261	3.04	Yes	No	0	8	9
96	R:R:L326	R:R:T330	11.8381	2.95	Yes	No	0	8	9
97	R:R:L374	R:R:Y375	10.6434	8.21	No	No	0	8	8
98	R:R:E385	R:R:V382	13.898	2.85	Yes	No	0	7	9
99	L:L:S2	R:R:Q356	16.5201	4.33	No	Yes	0	0	7
100	R:R:V176	R:R:Y134	30.3526	7.57	Yes	Yes	0	7	7
101	R:R:W219	R:R:W249	16.9805	19.68	Yes	No	11	9	9
102	R:R:I284	R:R:M214	65.501	2.92	Yes	Yes	0	7	6
103	R:R:I284	R:R:W259	23.8289	3.52	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:Q210	9.89	0	Yes	Yes	0	7	0	1
L:L:H1	R:R:I213	7.95	0	Yes	No	0	5	0	1
L:L:H1	R:R:I288	3.98	0	Yes	No	0	8	0	1
L:L:S2	R:R:Q356	4.33	0	No	Yes	0	7	0	1
L:L:S2	R:R:E360	5.75	0	No	No	0	7	0	1
L:L:S2	R:R:L361	3	0	No	Yes	0	7	0	1
L:L:D3	R:R:V176	7.3	0	No	Yes	0	7	0	1
L:L:D3	R:R:L361	5.43	0	No	Yes	0	7	0	1
L:L:I5	R:R:W281	3.52	0	No	Yes	0	6	0	1
L:L:I5	R:R:Q356	5.49	0	No	Yes	0	7	0	1
L:L:F6	R:R:V126	3.93	1	Yes	No	0	6	0	1
L:L:F6	R:R:Y130	7.22	1	Yes	Yes	0	7	0	1
L:L:F6	R:R:I357	3.77	1	Yes	No	0	6	0	1
L:L:F6	R:R:L361	6.09	1	Yes	Yes	0	7	0	1
L:L:T7	R:R:K179	10.51	1	No	Yes	0	6	0	1
L:L:T7	R:R:Y184	3.75	1	No	Yes	0	3	0	1
L:L:T7	R:R:D273	2.89	1	No	Yes	0	6	0	1
L:L:D8	R:R:T274	5.78	0	No	Yes	0	5	0	1
L:L:D8	R:R:N275	9.42	0	No	No	0	6	0	1
L:L:S9	R:R:Y123	8.9	0	No	Yes	0	5	0	1
L:L:Y10	R:R:Y123	6.95	0	No	Yes	0	5	0	1
L:L:Y10	R:R:Y184	16.88	0	No	Yes	0	3	0	1
L:L:S11	R:R:D273	8.83	1	No	Yes	0	6	0	1
L:L:S11	R:R:T274	3.2	1	No	Yes	0	5	0	1
L:L:R12	R:R:N81	4.82	0	No	Yes	0	5	0	1
L:L:Y13	R:R:D116	4.6	7	Yes	Yes	0	3	0	1
L:L:Y13	R:R:K119	3.58	7	Yes	No	0	3	0	1
L:L:Y13	R:R:I120	12.09	7	Yes	No	0	1	0	1
L:L:Y13	R:R:Y123	9.93	7	Yes	Yes	0	5	0	1
L:L:Q16	R:R:N81	10.56	0	No	Yes	0	5	0	1
L:L:V19	R:R:F79	10.49	0	No	Yes	0	5	0	1
L:L:K20	R:R:Y111	15.53	0	No	No	0	1	0	1
L:L:K20	R:R:D116	9.68	0	No	Yes	0	3	0	1
L:L:Y22	R:R:I59	7.25	3	No	No	0	6	0	1
L:L:V26	R:R:I59	4.61	3	No	No	0	6	0	1
R:R:E30	R:R:F79	5.83	0	No	Yes	5	5	2	1
R:R:I59	R:R:W56	7.05	3	No	Yes	6	7	1	2
R:R:P76	R:R:V78	3.53	8	No	No	9	5	2	2
R:R:F79	R:R:P76	5.78	8	Yes	No	5	9	1	2
R:R:F79	R:R:V78	5.24	8	Yes	No	5	5	1	2
R:R:F79	R:R:Y83	5.16	8	Yes	Yes	5	4	1	2
R:R:N81	R:R:Y83	6.98	0	Yes	Yes	5	4	1	2
R:R:D113	R:R:D116	13.31	10	No	Yes	1	3	2	1
R:R:K119	R:R:Y123	11.94	7	No	Yes	3	5	1	1
R:R:F122	R:R:V126	7.87	0	No	No	4	6	2	1
R:R:V176	R:R:Y130	5.05	1	Yes	Yes	7	7	1	1
R:R:L361	R:R:Y130	4.69	1	Yes	Yes	7	7	1	1
R:R:R172	R:R:Y134	4.12	5	Yes	Yes	8	7	2	2
R:R:V176	R:R:Y134	7.57	1	Yes	Yes	7	7	1	2
R:R:I213	R:R:R172	6.26	0	No	Yes	5	8	1	2
R:R:F217	R:R:R172	4.28	5	Yes	Yes	8	8	2	2
R:R:R172	R:R:Y341	3.09	5	Yes	Yes	8	8	2	2
R:R:S175	R:R:V176	3.23	1	Yes	Yes	6	7	2	1
R:R:L209	R:R:S175	6.01	1	Yes	Yes	6	6	2	2
R:R:L209	R:R:V176	4.47	1	Yes	Yes	6	7	2	1
R:R:K179	R:R:L183	4.23	1	Yes	Yes	6	6	1	2
R:R:K179	R:R:Y184	4.78	1	Yes	Yes	6	3	1	1
R:R:K179	R:R:L209	5.64	1	Yes	Yes	6	6	1	2
R:R:L183	R:R:Y184	9.38	1	Yes	Yes	6	3	2	1
R:R:D273	R:R:L183	4.07	1	Yes	Yes	6	6	1	2
R:R:L209	R:R:Q210	5.32	1	Yes	Yes	6	7	2	1
R:R:Q210	R:R:W259	6.57	1	Yes	Yes	7	8	1	2
R:R:I284	R:R:Q210	6.86	1	Yes	Yes	7	7	2	1
R:R:I284	R:R:M214	2.92	1	Yes	Yes	7	6	2	2
R:R:I288	R:R:M214	5.83	0	No	Yes	8	6	1	2
R:R:F217	R:R:I288	10.05	5	Yes	No	8	8	2	1
R:R:F217	R:R:Y341	13.41	5	Yes	Yes	8	8	2	2
R:R:I284	R:R:W259	3.52	1	Yes	Yes	7	8	2	2
R:R:D273	R:R:T274	4.34	1	Yes	Yes	6	5	1	1
R:R:D276	R:R:T274	5.78	0	No	Yes	3	5	2	1
R:R:N275	R:R:W281	13.56	0	No	Yes	6	6	1	1
R:R:I284	R:R:W281	3.52	1	Yes	Yes	7	6	2	1
R:R:R285	R:R:W281	12	0	No	Yes	6	6	2	1
R:R:E360	R:R:Y341	6.73	0	No	Yes	7	8	1	2
R:R:F344	R:R:Q356	3.51	14	No	Yes	7	7	2	1
R:R:F344	R:R:F359	8.57	14	No	No	7	5	2	2
R:R:I357	R:R:Q356	5.49	0	No	Yes	6	7	1	1
R:R:E360	R:R:F359	11.66	0	No	No	7	5	1	2
R:R:I349	R:R:Q356	2.74	0	No	Yes	5	7	2	1
R:R:K127	R:R:Y130	2.39	0	No	Yes	5	7	2	1
R:R:I120	R:R:T121	1.52	0	No	No	1	1	1	2
L:L:R14	R:R:S186	1.32	0	No	No	0	3	0	1
R:R:D116	R:R:E117	1.3	0	Yes	No	3	2	1	2
R:R:F82	R:R:N81	1.21	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WBJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.88
Number of Linked Nodes	355
Number of Links	393
Number of Hubs	61
Number of Links mediated by Hubs	206
Number of Communities	14
Number of Nodes involved in Communities	70
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	104
Number Of Links MetaPath	103
Number of Shortest Paths	105345
Length Of Smallest Path	3
Average Path Length	16.4902
Length of Longest Path	37
Minimum Path Strength	1.275
Average Path Strength	6.20502
Maximum Path Strength	26.37
Minimum Path Correlation	0.7
Average Path Correlation	0.960982
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	59.4645
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.8447
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell surface receptor signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of biological process • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • negative regulation of cellular process • muscle cell proliferation • cell-cell signaling • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • peptide hormone receptor binding • hormone receptor binding • vasoactive intestinal polypeptide receptor binding • type 2 vasoactive intestinal polypeptide receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • pituitary adenylate cyclase activating polypeptide activity • type 1 vasoactive intestinal polypeptide receptor binding • neuropeptide signaling pathway • chemokine (C-C motif) ligand 5 production • multicellular organismal process • positive regulation of biological process • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • biosynthetic process • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of chemokine (C-C motif) ligand 5 production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • negative regulation of cell cycle • cell cycle • regulation of cell cycle • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of G protein-coupled receptor signaling pathway • protein localization • regulation of localization • cellular localization • regulation of protein localization • localization • regulation of cellular localization • cellular macromolecule localization • macromolecule localization • positive regulation of adenylate cyclase activity • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • positive regulation of lyase activity • regulation of protein modification process • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of protein modification process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • protein metabolic process • positive regulation of protein kinase activity • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • protein phosphorylation • positive regulation of transferase activity • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • primary metabolic process • regulation of protein kinase activity • positive regulation of kinase activity • regulation of kinase activity • macromolecule modification • regulation of phosphorylation • regulation of phosphorus metabolic process • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • regulation of peptide hormone secretion • positive regulation of peptide secretion • growth hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of growth hormone secretion • regulation of peptide transport • positive regulation of peptide hormone secretion • export from cell • establishment of localization • regulation of secretion • peptide transport • positive regulation of growth hormone secretion • positive regulation of transport • peptide hormone secretion • hormone transport • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • establishment of protein localization • protein localization to extracellular region • establishment of protein localization to extracellular region • protein secretion • protein transport • insulin secretion • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • cellular component organization • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • cellular component organization or biogenesis • system development • somatodendritic compartment • cell body • perikaryon • neuronal cell body • cell projection • neuron projection • plasma membrane bounded cell projection • extracellular region • extracellular space • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • dendrite • dendritic tree • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • G-protein beta-subunit binding • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• FnI-like domain • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• FnI-like domain • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41587
Sequence	>7WBJ_nogp_Chain_R R F H L E I Q E E E T K C A E L L R S Q T E K H K A C S G V W D N I T C W R P A N V G E T V T V P C P K V F S N F Y S K A G N I S K N C T S D G W S E T F P D F V D A C G Y S D P E D E S K I T F Y I L V K A I Y T L G Y S V S L M S L A T G S I I L C L F R K L H C T R N Y I H L N L F L S F I L R A I S V L V K D D V L Y S S S G T L H C P D Q P S S W V G C K L S L V F L Q Y C I M A N F F W L L V E G L Y L H T L L V A M L P P R R C F L A Y L L I G W G L P T V C I G A W T A A R L Y L E D T G C W D T N D H S V P W W V I R I P I L I S I I V N F V L F I S I I R I L L Q K L T S Q Y K R L A K S T L L L I P L F G V H Y M V F A V F P I S I S S K Y Q I L F E L C L G S F Q G L V V A V L Y C F L N S E V Q C E L K R K W R S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WBJ	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3.42	2022-05-18	10.1038/s41467-022-30041-z
	7WBJ (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-		3.42	2022-05-18	10.1038/s41467-022-30041-z
	7VQX	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.74	2022-05-18	10.1038/s41467-022-30041-z
	7VQX (No Gprot)	B1	Peptide	VIP and PACAP	VPAC₁	Homo sapiens	PACAP27	-		2.74	2022-05-18	10.1038/s41467-022-30041-z

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