psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E32	R:R:N33	6.57	No	No	4	6	5
2	R:R:E32	R:R:F34	3.5	No	No	4	6	5
3	R:R:F34	R:R:N33	8.46	No	No	4	5	5
4	R:R:L37	R:R:N33	4.12	No	No	0	5	5
5	R:R:I286	R:R:T36	9.12	No	No	0	4	5
6	R:R:A97	R:R:L37	4.73	No	No	0	4	5
7	R:R:I43	R:R:V39	3.07	No	No	0	7	5
8	R:R:C290	R:R:F40	4.19	No	No	0	5	6
9	R:R:F40	R:R:Y293	7.22	No	Yes	0	6	7
10	R:R:L42	R:R:L46	4.15	No	No	0	5	5
11	R:R:I43	R:R:S297	3.1	No	No	0	7	8
12	R:R:F44	R:R:I89	8.79	No	Yes	1	7	7
13	R:R:F44	R:R:P90	10.11	No	No	1	7	8
14	R:R:D81	R:R:N51	6.73	Yes	No	1	9	9
15	R:R:L82	R:R:N51	5.49	No	No	1	8	9
16	R:R:N51	R:R:P300	6.52	No	No	1	9	9
17	R:R:L58	R:R:V54	2.98	Yes	No	5	7	9
18	R:R:S78	R:R:V54	4.85	No	No	0	8	9
19	R:R:F310	R:R:V54	3.93	Yes	No	5	8	9
20	R:R:F310	R:R:V57	6.55	Yes	No	0	8	7
21	R:R:V57	R:R:Y314	6.31	No	No	0	7	5
22	R:R:I74	R:R:L58	2.85	No	Yes	0	8	7
23	R:R:L58	R:R:L75	4.15	Yes	Yes	0	7	6
24	R:R:F310	R:R:L58	4.87	Yes	Yes	5	8	7
25	R:R:S61	R:R:V317	4.85	No	No	0	4	5
26	R:R:K62	R:R:R67	9.9	No	No	0	6	6
27	R:R:K65	R:R:P63	5.02	No	No	0	5	4
28	R:R:N71	R:R:S68	5.96	No	No	0	8	7
29	R:R:D132	R:R:T69	8.67	Yes	No	6	8	6
30	R:R:R147	R:R:T69	16.82	No	No	6	6	6
31	R:R:A152	R:R:T69	3.36	No	No	0	7	6
32	R:R:I74	R:R:T70	3.04	No	No	0	8	7
33	R:R:R147	R:R:T70	3.88	No	No	0	6	7
34	R:R:L153	R:R:L72	2.77	No	No	0	3	5
35	R:R:L72	R:R:V156	2.98	No	No	0	5	7
36	R:R:F73	R:R:M129	3.73	No	Yes	0	7	8
37	R:R:D132	R:R:F73	8.36	Yes	No	0	8	7
38	R:R:A152	R:R:F73	2.77	No	No	0	7	7
39	R:R:I74	R:R:M129	4.37	No	Yes	0	8	8
40	R:R:L75	R:R:S78	4.5	Yes	No	0	6	8
41	R:R:I79	R:R:L75	4.28	No	Yes	0	6	6
42	R:R:N76	R:R:V121	2.96	Yes	Yes	7	9	7
43	R:R:N76	R:R:T125	8.77	Yes	No	0	9	7
44	R:R:N76	R:R:V156	7.39	Yes	No	0	9	7
45	R:R:N76	R:R:W160	9.04	Yes	No	7	9	9
46	R:R:D81	R:R:L77	5.43	Yes	No	0	9	9
47	R:R:L77	R:R:T125	4.42	No	No	0	9	7
48	R:R:L126	R:R:L77	2.77	No	No	0	8	9
49	R:R:D81	R:R:S296	10.31	Yes	No	1	9	9
50	R:R:D81	R:R:N299	8.08	Yes	No	0	9	9
51	R:R:D81	R:R:P300	3.22	Yes	No	1	9	9
52	R:R:L82	R:R:L86	8.3	No	No	1	8	5
53	R:R:A83	R:R:S118	3.42	No	No	0	6	8
54	R:R:L85	R:R:Y84	3.52	No	Yes	1	7	7
55	R:R:C88	R:R:Y84	5.38	Yes	Yes	1	7	7
56	R:R:F115	R:R:Y84	6.19	No	Yes	1	5	7
57	R:R:W260	R:R:Y84	4.82	Yes	Yes	1	8	7
58	R:R:Y293	R:R:Y84	2.98	Yes	Yes	1	7	7
59	R:R:S296	R:R:Y84	3.82	No	Yes	1	9	7
60	R:R:I89	R:R:L85	2.85	Yes	No	1	7	7
61	R:R:L85	R:R:S296	9.01	No	No	1	7	9
62	R:R:F114	R:R:F87	8.57	No	No	0	5	5
63	R:R:C88	R:R:Q92	6.1	Yes	Yes	1	7	6
64	R:R:C88	R:R:F115	8.38	Yes	No	1	7	5
65	R:R:C88	R:R:Y293	5.38	Yes	Yes	1	7	7
66	R:R:I89	R:R:P90	5.08	Yes	No	1	7	8
67	R:R:I89	R:R:Y293	21.76	Yes	Yes	1	7	7
68	R:R:F91	R:R:I111	15.07	No	No	0	6	5
69	R:R:H289	R:R:Q92	4.95	Yes	Yes	1	5	6
70	R:R:Q92	R:R:Y293	7.89	Yes	Yes	1	6	7
71	L:L:Y9	R:R:Q92	9.02	No	Yes	0	0	6
72	R:R:L98	R:R:T94	4.42	No	No	0	3	4
73	L:L:N5	R:R:V95	5.91	No	No	0	0	4
74	L:L:Y9	R:R:V95	3.79	No	No	0	0	4
75	R:R:R285	R:R:Y96	3.09	Yes	No	1	4	4
76	R:R:H289	R:R:Y96	8.71	Yes	No	1	5	4
77	L:L:S6	R:R:Y96	3.82	No	No	0	0	4
78	R:R:L98	R:R:P99	3.28	No	No	0	3	4
79	R:R:L103	R:R:W101	13.67	No	Yes	0	7	8
80	R:R:G104	R:R:W101	2.81	No	Yes	0	8	8
81	R:R:C108	R:R:W101	5.22	Yes	Yes	3	9	8
82	R:R:C187	R:R:W101	18.28	Yes	Yes	3	9	8
83	R:R:I107	R:R:L103	9.99	No	No	0	5	7
84	R:R:A105	R:R:L176	3.15	No	No	0	2	5
85	R:R:I107	R:R:I111	4.42	No	No	0	5	5
86	R:R:C108	R:R:L176	3.17	Yes	No	0	9	5
87	R:R:C108	R:R:C187	7.28	Yes	Yes	3	9	9
88	R:R:F110	R:R:F114	10.72	No	No	0	4	5
89	R:R:H112	R:R:I111	6.63	Yes	No	0	5	5
90	R:R:H112	R:R:Q174	17.31	Yes	No	3	5	4
91	R:R:C187	R:R:H112	4.42	Yes	Yes	3	9	5
92	L:L:Y9	R:R:H112	10.89	No	Yes	0	0	5
93	R:R:V117	R:R:Y113	8.83	No	No	0	5	5
94	R:R:I164	R:R:Y113	3.63	No	No	0	4	5
95	R:R:A171	R:R:Y113	5.34	No	No	0	5	5
96	R:R:F115	R:R:T116	9.08	No	Yes	0	5	5
97	R:R:L120	R:R:T116	2.95	No	Yes	0	6	5
98	R:R:A167	R:R:T116	3.36	No	Yes	0	6	5
99	R:R:T116	R:R:V170	4.76	Yes	No	0	5	4
100	R:R:S163	R:R:V117	3.23	No	No	0	8	5
101	R:R:M119	R:R:W260	6.98	No	Yes	0	7	8
102	R:R:L120	R:R:M166	7.07	No	No	0	6	5
103	R:R:V121	R:R:W160	15.94	Yes	No	7	7	9
104	R:R:S163	R:R:V121	4.85	No	Yes	0	8	7
105	R:R:I123	R:R:P212	3.39	No	Yes	0	7	9
106	R:R:F124	R:R:I159	7.54	No	No	0	5	7
107	R:R:L126	R:R:Y303	5.86	No	Yes	0	8	9
108	R:R:M129	R:R:R133	9.93	Yes	No	2	8	9
109	R:R:M129	R:R:Y303	4.79	Yes	Yes	2	8	9
110	R:R:I216	R:R:S130	10.84	No	No	2	8	9
111	R:R:S130	R:R:Y220	3.82	No	Yes	2	9	9
112	R:R:C219	R:R:V131	3.42	No	No	0	7	5
113	R:R:D132	R:R:R147	11.91	Yes	No	6	8	6
114	R:R:R133	R:R:Y220	7.2	No	Yes	2	9	9
115	R:R:R133	R:R:Y303	8.23	No	Yes	2	9	9
116	R:R:V135	R:R:Y134	3.79	No	Yes	0	5	8
117	R:R:V138	R:R:Y134	3.79	No	Yes	0	7	8
118	R:R:C219	R:R:Y134	8.06	No	Yes	0	7	8
119	R:R:K222	R:R:Y134	3.58	No	Yes	0	5	8
120	R:R:I137	R:R:V223	7.68	No	No	0	8	8
121	R:R:H226	R:R:I137	5.3	No	No	0	5	8
122	R:R:H139	R:R:V138	2.77	No	No	0	6	7
123	R:R:H139	R:R:R142	3.39	No	No	0	6	5
124	R:R:L146	R:R:R142	3.64	No	No	0	3	5
125	R:R:L146	R:R:S145	3	No	No	0	3	2
126	R:R:R150	R:R:V148	3.92	No	No	0	5	7
127	R:R:L153	R:R:S149	3	No	No	0	3	1
128	R:R:H173	R:R:P169	3.05	Yes	No	0	5	6
129	R:R:P169	R:R:Y200	12.52	No	No	0	6	5
130	R:R:V170	R:R:Y200	3.79	No	No	0	4	5
131	R:R:H173	R:R:Y172	13.07	Yes	No	0	5	4
132	R:R:H173	R:R:W191	34.91	Yes	Yes	0	5	5
133	R:R:H173	R:R:P192	3.05	Yes	No	0	5	4
134	R:R:C187	R:R:Q174	3.05	Yes	No	3	9	4
135	R:R:E189	R:R:Q174	15.29	No	No	0	4	4
136	R:R:L176	R:R:T185	5.9	No	No	0	5	3
137	R:R:F177	R:R:W188	8.02	Yes	No	0	2	5
138	R:R:F177	R:R:Q190	10.54	Yes	No	8	2	4
139	L:L:P13	R:R:F177	5.78	No	Yes	8	0	2
140	R:R:H178	R:R:T185	17.8	No	No	0	3	3
141	R:R:P179	R:R:Q184	7.9	No	No	9	2	3
142	R:R:F186	R:R:P179	5.78	Yes	No	9	4	2
143	L:L:V16	R:R:R180	3.92	No	No	0	0	1
144	R:R:F186	R:R:Q184	10.54	Yes	No	9	4	3
145	R:R:F186	R:R:W188	20.04	Yes	No	0	4	5
146	L:L:N5	R:R:F186	8.46	No	Yes	0	0	4
147	L:L:G8	R:R:W188	7.04	No	No	0	0	5
148	R:R:E189	R:R:W191	4.36	No	Yes	0	4	5
149	L:L:P13	R:R:Q190	3.16	No	No	8	0	4
150	R:R:K197	R:R:W191	27.85	No	Yes	0	4	5
151	R:R:W191	R:R:Y200	6.75	Yes	No	0	5	5
152	R:R:D193	R:R:P192	6.44	No	No	0	5	4
153	R:R:D193	R:R:R195	8.34	No	No	10	5	3
154	R:R:D193	R:R:H196	21.43	No	No	10	5	2
155	R:R:H196	R:R:R195	9.03	No	No	10	2	3
156	R:R:E271	R:R:K197	18.9	Yes	No	0	5	4
157	R:R:E271	R:R:K198	8.1	Yes	No	11	5	2
158	R:R:F272	R:R:K198	9.93	No	No	11	5	2
159	R:R:E271	R:R:V201	8.56	Yes	No	0	5	5
160	R:R:C203	R:R:F207	2.79	No	No	0	3	5
161	R:R:F205	R:R:Y209	5.16	No	Yes	13	5	8
162	R:R:F205	R:R:H264	10.18	No	No	13	5	7
163	R:R:F205	R:R:L268	8.53	No	No	0	5	5
164	R:R:F207	R:R:V206	3.93	No	No	12	5	4
165	R:R:L211	R:R:V206	2.98	No	No	12	5	4
166	R:R:F207	R:R:L211	3.65	No	No	12	5	5
167	R:R:G208	R:R:P212	4.06	No	Yes	0	6	9
168	R:R:L213	R:R:Y209	3.52	No	Yes	0	6	8
169	R:R:L261	R:R:Y209	9.38	No	Yes	0	6	8
170	R:R:H264	R:R:Y209	9.8	No	Yes	13	7	8
171	R:R:L210	R:R:L214	5.54	No	No	0	4	4
172	R:R:F256	R:R:P212	2.89	No	Yes	0	9	9
173	R:R:C217	R:R:L213	3.17	No	No	0	4	6
174	R:R:F256	R:R:L213	6.09	No	No	0	9	6
175	R:R:C219	R:R:L215	3.17	No	No	0	7	7
176	R:R:I216	R:R:Y220	3.63	No	Yes	2	8	9
177	R:R:F218	R:R:K222	11.17	No	No	0	5	5
178	R:R:V249	R:R:Y220	8.83	No	Yes	0	7	9
179	R:R:V252	R:R:Y220	3.79	No	Yes	0	8	9
180	R:R:L227	R:R:V223	2.98	No	No	0	8	8
181	R:R:L224	R:R:V249	4.47	No	No	0	5	7
182	R:R:K229	R:R:N225	6.99	No	No	0	4	3
183	R:R:H226	R:R:K230	11.79	No	No	0	5	5
184	R:R:L227	R:R:L231	4.15	No	No	0	8	3
185	R:R:L227	R:R:T245	4.42	No	No	0	8	7
186	R:R:L231	R:R:S238	6.01	No	No	14	3	4
187	R:R:K242	R:R:L231	5.64	Yes	No	14	6	3
188	R:R:N233	R:R:S235	5.96	No	No	0	2	4
189	R:R:N233	R:R:S238	7.45	No	No	0	2	4
190	R:R:K242	R:R:S238	6.12	Yes	No	14	6	4
191	R:R:E239	R:R:K242	10.8	No	Yes	0	2	6
192	R:R:K243	R:R:Q247	5.42	No	No	0	4	5
193	R:R:L250	R:R:V254	2.98	No	No	0	4	4
194	R:R:V252	R:R:Y303	6.31	No	Yes	0	8	9
195	R:R:I302	R:R:V255	4.61	No	No	0	8	6
196	R:R:S259	R:R:W260	8.65	No	Yes	1	8	8
197	R:R:N295	R:R:S259	8.94	No	No	1	9	8
198	R:R:A292	R:R:W260	3.89	No	Yes	0	7	8
199	R:R:N295	R:R:W260	16.95	No	Yes	1	9	8
200	R:R:L261	R:R:P262	3.28	No	No	0	6	9
201	R:R:L291	R:R:P262	3.28	No	No	0	8	9
202	R:R:H263	R:R:H267	19.11	No	No	1	6	5
203	R:R:H263	R:R:R285	3.39	No	Yes	1	6	4
204	R:R:F284	R:R:I266	13.82	No	No	0	5	5
205	R:R:I266	R:R:R285	3.76	No	Yes	0	5	4
206	R:R:H267	R:R:R285	6.77	No	Yes	1	5	4
207	R:R:F275	R:R:W269	4.01	Yes	No	1	1	4
208	R:R:P276	R:R:W269	4.05	Yes	No	1	3	4
209	L:L:L10	R:R:A270	3.15	Yes	No	0	0	3
210	R:R:E271	R:R:F272	4.66	Yes	No	11	5	5
211	R:R:F275	R:R:P276	4.33	Yes	Yes	1	1	3
212	R:R:F275	R:R:S281	6.61	Yes	No	1	1	3
213	L:L:W2	R:R:F275	6.01	Yes	Yes	0	0	1
214	L:L:L10	R:R:F275	7.31	Yes	Yes	1	0	1
215	L:L:L11	R:R:F275	4.87	No	Yes	1	0	1
216	R:R:P276	R:R:T278	5.25	Yes	Yes	1	3	4
217	R:R:P276	R:R:S281	5.34	Yes	No	1	3	3
218	L:L:W2	R:R:L277	7.97	Yes	No	0	0	1
219	R:R:S281	R:R:T278	4.8	No	Yes	1	3	4
220	R:R:F282	R:R:I286	10.05	Yes	No	0	4	4
221	L:L:G1	R:R:F282	4.52	No	Yes	0	0	4
222	L:L:W2	R:R:F282	7.02	Yes	Yes	0	0	4
223	R:R:F284	R:R:T287	3.89	No	No	0	5	5
224	R:R:H289	R:R:R285	15.8	Yes	Yes	1	5	4
225	L:L:L10	R:R:R285	4.86	Yes	Yes	1	0	4
226	R:R:H289	R:R:Y293	3.27	Yes	Yes	1	5	7
227	R:R:L291	R:R:S294	3	No	No	0	8	5
228	R:R:N295	R:R:N299	10.9	No	No	0	9	9
229	R:R:S297	R:R:V298	3.23	No	No	0	8	7
230	R:R:I301	R:R:V298	7.68	No	No	0	6	7
231	R:R:I302	R:R:V298	3.07	No	No	0	8	7
232	R:R:F305	R:R:I301	3.77	No	No	0	6	6
233	R:R:I302	R:R:Y303	3.63	No	Yes	0	8	9
234	R:R:A304	R:R:F310	8.32	No	Yes	0	6	8
235	R:R:F305	R:R:F310	6.43	No	Yes	0	6	8
236	R:R:E308	R:R:R311	3.49	No	No	0	4	8
237	R:R:F318	R:R:Y314	13.41	No	No	0	5	5
238	R:R:Q316	R:R:V317	4.3	No	No	0	4	5
239	L:L:S6	L:L:W2	4.94	No	Yes	0	0	0
240	L:L:A7	L:L:W2	3.89	No	Yes	0	0	0
241	L:L:L10	L:L:L11	2.77	Yes	No	1	0	0
242	L:L:G12	L:L:P13	4.06	No	No	0	0	0
243	R:R:F124	R:R:S163	2.64	No	No	0	5	8
244	R:R:R60	R:R:V317	2.62	No	No	0	5	5
245	R:R:F272	R:R:V202	2.62	No	No	0	5	5
246	R:R:V223	R:R:Y134	2.52	No	Yes	0	8	8
247	R:R:F256	R:R:I216	2.51	No	No	0	9	8
248	R:R:F305	R:R:L53	2.44	No	No	0	6	6
249	R:R:F87	R:R:L86	2.44	No	No	0	5	5
250	R:R:F124	R:R:L162	2.44	No	No	0	5	4
251	R:R:L75	R:R:R67	2.43	Yes	No	0	6	6
252	R:R:L306	R:R:R311	2.43	No	No	0	6	8
253	R:R:K315	R:R:Y314	2.39	No	No	0	6	5
254	R:R:C108	R:R:G175	1.96	Yes	No	0	9	4
255	R:R:A127	R:R:P212	1.87	No	Yes	0	7	9
256	R:R:A288	R:R:P262	1.87	No	No	0	6	9
257	R:R:G47	R:R:S297	1.86	No	No	0	8	8
258	L:L:A15	L:L:A7	1.79	No	No	0	0	0
259	R:R:P63	R:R:S61	1.78	No	No	0	4	4
260	R:R:P169	R:R:S168	1.78	No	No	0	6	4
261	R:R:P279	R:R:T278	1.75	No	Yes	0	2	4
262	R:R:G175	R:R:K109	1.74	No	No	0	4	6
263	R:R:G47	R:R:L46	1.71	No	No	0	8	5
264	R:R:G50	R:R:L49	1.71	No	No	0	7	4
265	R:R:A313	R:R:S61	1.71	No	No	0	5	4
266	R:R:A80	R:R:S122	1.71	No	No	0	8	9
267	R:R:C217	R:R:V253	1.71	No	No	0	4	7
268	R:R:A80	R:R:V121	1.7	No	Yes	0	8	7
269	R:R:A280	R:R:T278	1.68	No	Yes	0	3	4
270	R:R:K62	R:R:P63	1.67	No	No	0	6	4
271	R:R:K65	R:R:P66	1.67	No	No	0	5	7
272	R:R:K198	R:R:P194	1.67	No	No	0	2	2
273	L:L:G1	R:R:E32	1.64	No	No	0	0	6
274	R:R:L211	R:R:P212	1.64	No	Yes	0	5	9
275	R:R:A128	R:R:I159	1.62	No	No	0	7	7
276	R:R:S130	R:R:V131	1.62	No	No	0	9	5
277	R:R:V35	R:R:V39	1.6	No	No	0	5	5
278	R:R:S68	R:R:T70	1.6	No	No	0	7	7
279	R:R:V251	R:R:V255	1.6	No	No	0	6	6
280	L:L:S6	L:L:T3	1.6	No	No	0	0	0
281	R:R:T56	R:R:V57	1.59	No	No	0	4	7
282	R:R:T100	R:R:V102	1.59	No	No	0	4	1
283	R:R:T248	R:R:V252	1.59	No	No	0	8	8
284	R:R:A93	R:R:L37	1.58	No	No	0	7	5
285	R:R:A181	R:R:N183	1.56	No	No	0	3	5
286	R:R:A136	R:R:D132	1.54	No	Yes	0	8	8
287	R:R:K242	R:R:S241	1.53	Yes	No	0	6	5
288	R:R:I55	R:R:T56	1.52	No	No	0	7	4
289	R:R:F40	R:R:G41	1.51	No	No	0	6	5
290	R:R:F44	R:R:G41	1.51	No	No	0	7	5
291	R:R:L49	R:R:S52	1.5	No	No	0	4	3
292	R:R:L53	R:R:S52	1.5	No	No	0	6	3
293	R:R:L82	R:R:V48	1.49	No	No	1	8	7
294	R:R:L86	R:R:V48	1.49	No	No	1	5	7
295	R:R:L98	R:R:V102	1.49	No	No	0	3	1
296	R:R:N309	R:R:S307	1.49	No	No	0	6	8
297	R:R:N151	R:R:V148	1.48	No	No	0	4	7
298	R:R:I265	R:R:I266	1.47	No	No	0	6	5
299	L:L:L4	L:L:T3	1.47	No	No	0	0	0
300	R:R:G257	R:R:Y209	1.45	No	Yes	0	5	8
301	R:R:E308	R:R:S307	1.44	No	No	0	4	8
302	R:R:Q184	R:R:T100	1.42	No	No	0	3	4
303	R:R:E308	R:R:K244	1.35	No	No	0	4	7
304	R:R:F310	R:R:S307	1.32	Yes	No	0	8	8
305	R:R:S118	R:R:Y84	1.27	No	Yes	0	8	7
306	R:R:F106	R:R:I107	1.26	No	No	0	1	5
307	R:R:F282	R:R:L283	1.22	Yes	No	0	4	1
308	R:R:R141	R:R:R142	1.07	No	No	0	5	5
309	R:R:F177	R:R:R180	1.07	Yes	No	0	2	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L58	3.7125	4	5	7
2	R:R:L75	3.84	4	0	6
3	R:R:N76	7.04	4	7	9
4	R:R:D81	6.754	5	1	9
5	R:R:Y84	3.99714	7	1	7
6	R:R:C88	6.31	4	1	7
7	R:R:I89	9.62	4	1	7
8	R:R:Q92	6.99	4	1	6
9	R:R:W101	9.995	4	3	8
10	R:R:C108	4.4075	4	3	9
11	R:R:H112	9.8125	4	3	5
12	R:R:T116	5.0375	4	0	5
13	R:R:V121	6.3625	4	7	7
14	R:R:M129	5.705	4	2	8
15	R:R:D132	7.62	4	6	8
16	R:R:Y134	4.348	5	0	8
17	R:R:H173	13.52	4	0	5
18	R:R:F177	6.3525	4	8	2
19	R:R:F186	11.205	4	9	4
20	R:R:C187	8.2575	4	3	9
21	R:R:W191	18.4675	4	0	5
22	R:R:Y209	5.862	5	13	8
23	R:R:P212	2.77	5	0	9
24	R:R:Y220	5.454	5	2	9
25	R:R:K242	6.0225	4	14	6
26	R:R:W260	8.258	5	1	8
27	R:R:E271	10.055	4	11	5
28	R:R:F275	5.52333	6	1	1
29	R:R:P276	4.7425	4	1	3
30	R:R:T278	3.37	4	1	4
31	R:R:F282	5.7025	4	0	4
32	R:R:R285	6.27833	6	1	4
33	R:R:H289	8.1825	4	1	5
34	R:R:Y293	8.08333	6	1	7
35	R:R:Y303	5.764	5	2	9
36	R:R:F310	5.23667	6	5	8
37	L:L:W2	5.966	5	0	0
38	L:L:L10	4.5225	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:W2	R:R:F282	10.884	7.02	Yes	Yes	0	0	4
2	L:L:S6	L:L:W2	13.9322	4.94	No	Yes	0	0	0
3	L:L:S6	R:R:Y96	16.4358	3.82	No	No	0	0	4
4	R:R:H289	R:R:Y96	16.7989	8.71	Yes	No	1	5	4
5	R:R:H289	R:R:Y293	27.7913	3.27	Yes	Yes	1	5	7
6	R:R:Y293	R:R:Y84	52.8213	2.98	Yes	Yes	1	7	7
7	R:R:S296	R:R:Y84	93.3736	3.82	No	Yes	1	9	7
8	R:R:D81	R:R:S296	96.4364	10.31	Yes	No	1	9	9
9	R:R:D81	R:R:L77	100	5.43	Yes	No	0	9	9
10	R:R:L126	R:R:L77	99.4729	2.77	No	No	0	8	9
11	R:R:L126	R:R:Y303	99.3734	5.86	No	Yes	0	8	9
12	R:R:I302	R:R:Y303	16.0317	3.63	No	Yes	0	8	9
13	R:R:I302	R:R:V298	13.3349	3.07	No	No	0	8	7
14	R:R:M129	R:R:Y303	25.9377	4.79	Yes	Yes	2	8	9
15	R:R:I74	R:R:M129	27.68	4.37	No	Yes	0	8	8
16	R:R:I74	R:R:L58	24.5791	2.85	No	Yes	0	8	7
17	R:R:L58	R:R:L75	11.3818	4.15	Yes	Yes	0	7	6
18	R:R:F310	R:R:L58	12.9747	4.87	Yes	Yes	5	8	7
19	R:R:L77	R:R:T125	19.5807	4.42	No	No	0	9	7
20	R:R:N76	R:R:T125	18.6027	8.77	Yes	No	0	9	7
21	R:R:N76	R:R:V121	12.5765	2.96	Yes	Yes	7	9	7
22	R:R:C88	R:R:Q92	25.8675	6.1	Yes	Yes	1	7	6
23	R:R:F115	R:R:Y84	20.4181	6.19	No	Yes	1	5	7
24	L:L:Y9	R:R:Q92	54.7832	9.02	No	Yes	0	0	6
25	L:L:Y9	R:R:H112	30.3622	10.89	No	Yes	0	0	5
26	L:L:Y9	R:R:V95	27.1295	3.79	No	No	0	0	4
27	L:L:N5	R:R:V95	25.6742	5.91	No	No	0	0	4
28	L:L:N5	R:R:F186	24.1984	8.46	No	Yes	0	0	4
29	L:L:L10	R:R:R285	12.0816	4.86	Yes	Yes	1	0	4
30	R:R:C187	R:R:H112	16.0288	4.42	Yes	Yes	3	9	5
31	R:R:C108	R:R:C187	10.8196	7.28	Yes	Yes	3	9	9
32	R:R:F115	R:R:T116	22.7168	9.08	No	Yes	0	5	5
33	R:R:T116	R:R:V170	18.6027	4.76	Yes	No	0	5	4
34	R:R:R133	R:R:Y303	34.4148	8.23	No	Yes	2	9	9
35	R:R:R133	R:R:Y220	41.3663	7.2	No	Yes	2	9	9
36	R:R:I216	R:R:Y220	33.021	3.63	No	Yes	2	8	9
37	R:R:F256	R:R:I216	33.3812	2.51	No	No	0	9	8
38	R:R:F256	R:R:P212	12.5062	2.89	No	Yes	0	9	9
39	R:R:V252	R:R:Y303	35.346	6.31	No	Yes	0	8	9
40	R:R:V252	R:R:Y220	34.1454	3.79	No	Yes	0	8	9
41	R:R:S130	R:R:Y220	38.7631	3.82	No	Yes	2	9	9
42	R:R:C219	R:R:V131	37.709	3.42	No	No	0	7	5
43	R:R:S130	R:R:V131	39.1467	1.62	No	No	0	9	5
44	R:R:C219	R:R:Y134	34.816	8.06	No	Yes	0	7	8
45	R:R:V223	R:R:Y134	19.9994	2.52	No	Yes	0	8	8
46	R:R:V170	R:R:Y200	17.7037	3.79	No	No	0	4	5
47	R:R:F186	R:R:W188	12.2778	20.04	Yes	No	0	4	5
48	R:R:F256	R:R:L213	20.0199	6.09	No	No	0	9	6
49	R:R:L213	R:R:Y209	15.4607	3.52	No	Yes	0	6	8
50	R:R:L227	R:R:V223	13.9059	2.98	No	No	0	8	8
51	R:R:L227	R:R:L231	10.9631	4.15	No	No	0	8	3
52	R:R:C88	R:R:Y84	24.6171	5.38	Yes	Yes	1	7	7
53	R:R:Q92	R:R:Y293	25.1471	7.89	Yes	Yes	1	6	7
54	R:R:H289	R:R:R285	17.5163	15.8	Yes	Yes	1	5	4
55	R:R:W191	R:R:Y200	10.8899	6.75	Yes	No	0	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E32	R:R:N33	6.57	4	No	No	6	5	1	2
R:R:E32	R:R:F34	3.5	4	No	No	6	5	1	2
R:R:F34	R:R:N33	8.46	4	No	No	5	5	2	2
R:R:C88	R:R:Q92	6.1	1	Yes	Yes	7	6	2	1
R:R:C88	R:R:Y293	5.38	1	Yes	Yes	7	7	2	2
R:R:H289	R:R:Q92	4.95	1	Yes	Yes	5	6	2	1
R:R:Q92	R:R:Y293	7.89	1	Yes	Yes	6	7	1	2
L:L:Y9	R:R:Q92	9.02	0	No	Yes	0	6	0	1
L:L:N5	R:R:V95	5.91	0	No	No	0	4	0	1
L:L:Y9	R:R:V95	3.79	0	No	No	0	4	0	1
R:R:R285	R:R:Y96	3.09	1	Yes	No	4	4	1	1
R:R:H289	R:R:Y96	8.71	1	Yes	No	5	4	2	1
L:L:S6	R:R:Y96	3.82	0	No	No	0	4	0	1
R:R:H112	R:R:I111	6.63	3	Yes	No	5	5	1	2
R:R:H112	R:R:Q174	17.31	3	Yes	No	5	4	1	2
R:R:C187	R:R:H112	4.42	3	Yes	Yes	9	5	2	1
L:L:Y9	R:R:H112	10.89	0	No	Yes	0	5	0	1
R:R:C187	R:R:Q174	3.05	3	Yes	No	9	4	2	2
R:R:F177	R:R:W188	8.02	8	Yes	No	2	5	1	1
R:R:F177	R:R:Q190	10.54	8	Yes	No	2	4	1	1
L:L:P13	R:R:F177	5.78	8	No	Yes	0	2	0	1
R:R:P179	R:R:Q184	7.9	9	No	No	2	3	2	2
R:R:F186	R:R:P179	5.78	9	Yes	No	4	2	1	2
L:L:V16	R:R:R180	3.92	0	No	No	0	1	0	1
R:R:F186	R:R:Q184	10.54	9	Yes	No	4	3	1	2
R:R:F186	R:R:W188	20.04	9	Yes	No	4	5	1	1
L:L:N5	R:R:F186	8.46	0	No	Yes	0	4	0	1
L:L:G8	R:R:W188	7.04	0	No	No	0	5	0	1
L:L:P13	R:R:Q190	3.16	8	No	No	0	4	0	1
R:R:H263	R:R:H267	19.11	1	No	No	6	5	2	2
R:R:H263	R:R:R285	3.39	1	No	Yes	6	4	2	1
R:R:I266	R:R:R285	3.76	0	No	Yes	5	4	2	1
R:R:H267	R:R:R285	6.77	1	No	Yes	5	4	2	1
R:R:F275	R:R:W269	4.01	1	Yes	No	1	4	1	2
R:R:P276	R:R:W269	4.05	1	Yes	No	3	4	2	2
L:L:L10	R:R:A270	3.15	1	Yes	No	0	3	0	1
R:R:F275	R:R:P276	4.33	1	Yes	Yes	1	3	1	2
R:R:F275	R:R:S281	6.61	1	Yes	No	1	3	1	2
L:L:W2	R:R:F275	6.01	0	Yes	Yes	0	1	0	1
L:L:L10	R:R:F275	7.31	1	Yes	Yes	0	1	0	1
L:L:L11	R:R:F275	4.87	1	No	Yes	0	1	0	1
R:R:P276	R:R:S281	5.34	1	Yes	No	3	3	2	2
L:L:W2	R:R:L277	7.97	0	Yes	No	0	1	0	1
R:R:F282	R:R:I286	10.05	0	Yes	No	4	4	1	2
L:L:G1	R:R:F282	4.52	0	No	Yes	0	4	0	1
L:L:W2	R:R:F282	7.02	0	Yes	Yes	0	4	0	1
R:R:H289	R:R:R285	15.8	1	Yes	Yes	5	4	2	1
L:L:L10	R:R:R285	4.86	1	Yes	Yes	0	4	0	1
R:R:H289	R:R:Y293	3.27	1	Yes	Yes	5	7	2	2
L:L:G1	R:R:E32	1.64	0	No	No	0	6	0	1
R:R:F282	R:R:L283	1.22	0	Yes	No	4	1	1	2
R:R:F177	R:R:R180	1.07	8	Yes	No	2	1	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WQ3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	274
Number of Links	309
Number of Hubs	38
Number of Links mediated by Hubs	146
Number of Communities	14
Number of Nodes involved in Communities	75
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	56460
Length Of Smallest Path	3
Average Path Length	14.9494
Length of Longest Path	29
Minimum Path Strength	1.37
Average Path Strength	5.8109
Maximum Path Strength	31.38
Minimum Path Correlation	0.7
Average Path Correlation	0.932518
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	50.0305
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.1923
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • positive regulation of cell communication • multicellular organismal process • regulation of localization • system process • positive regulation of steroid hormone secretion • regulation of system process • regulation of glucocorticoid secretion • localization • positive regulation of cortisol secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • regulation of biological quality • cortisol secretion • positive regulation of corticosteroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • positive regulation of lipid transport • lipid export from cell • regulation of cortisol secretion • positive regulation of multicellular organismal process • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of hormone secretion • transport • steroid hormone secretion • positive regulation of biological process • regulation of lipid transport • organic hydroxy compound transport • positive regulation of secretion by cell • hormone secretion • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • lipid localization • export from cell • cell-cell signaling • positive regulation of lipid localization • endocrine process • positive regulation of transport • regulation of lipid localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • neuropeptide signaling pathway • positive regulation of cytosolic calcium ion concentration • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • cellular anatomical structure • membrane • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • amide transport • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • galanin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • galanin receptor binding • neuropeptide receptor binding • type 2 galanin receptor binding • type 1 galanin receptor binding • type 3 galanin receptor binding • response to xenobiotic stimulus • response to estrogen • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • regulation of developmental process • epidermis development • molting cycle process • regulation of hair cycle • catagen • hair cycle phase • positive regulation of hair follicle maturation • positive regulation of developmental process • multicellular organism development • regulation of timing of catagen • skin epidermis development • hair follicle development • anatomical structure development • positive regulation of timing of catagen • hair follicle maturation • developmental process • regulation of hair follicle maturation • epithelium development • regulation of multicellular organismal development • biological phase • hair cycle • animal organ development • developmental maturation • tissue development • positive regulation of hair follicle development • skin development • anatomical structure maturation • molting cycle • regulation of hair follicle development • hair cycle process • behavior • feeding behavior • positive regulation of cation transmembrane transport • monoatomic ion transmembrane transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • positive regulation of large conductance calcium-activated potassium channel activity • monoatomic cation transmembrane transport • positive regulation of molecular function • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of monoatomic ion transport • positive regulation of cation channel activity • transmembrane transport • regulation of transmembrane transport • positive regulation of transporter activity • positive regulation of ion transmembrane transporter activity • regulation of monoatomic cation transmembrane transport • negative regulation of lymphocyte proliferation • regulation of leukocyte activation • regulation of cell activation • lymphocyte activation • negative regulation of lymphocyte activation • leukocyte proliferation • leukocyte activation • negative regulation of mononuclear cell proliferation • negative regulation of leukocyte proliferation • lymphocyte proliferation • regulation of immune system process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • negative regulation of cell population proliferation • cell population proliferation • cell activation • negative regulation of cell activation • negative regulation of immune system process • regulation of cell population proliferation • mononuclear cell proliferation • regulation of mononuclear cell proliferation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • regulation of lymphocyte activation • regulation of hormone metabolic process • hormone metabolic process • glucocorticoid metabolic process • regulation of glucocorticoid metabolic process • nervous system development • system development • response to immobilization stress • response to stress • response to insulin • parental behavior • reproductive process • multicellular organismal reproductive process • reproductive behavior • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • somatodendritic compartment • cell body • neuronal cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • cardiac muscle cell apoptotic process • photoreceptor inner segment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47211
Sequence	>7WQ3_nogp_Chain_R E N F V T L V V F G L I F A L G V L G N S L V I T V L A R S K P G K P R S T T N L F I L N L S I A D L A Y L L F C I P F Q A T V Y A L P T W V L G A F I C K F I H Y F F T V S M L V S I F T L A A M S V D R Y V A I V H S R R S S S L R V S R N A L L G V G C I W A L S I A M A S P V A Y H Q G L F H P R A S N Q T F C W E Q W P D P R H K K A Y V V C T F V F G Y L L P L L L I C F C Y A K V L N H L H K K L K N M S K K S E A S K K K T A Q T V L V V V V V F G I S W L P H H I I H L W A E F G V F P L T P A S F L F R I T A H C L A Y S N S S V N P I I Y A F L S E N F R K A Y K Q V F K C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WQ3	A	Peptide	Galanin	GAL₁	Homo sapiens	Galanin	-	Gi1/β1/γ2	2.7	2022-04-20	doi.org/10.1038/s41467-022-29072-3
	7WQ3 (No Gprot)	A	Peptide	Galanin	GAL₁	Homo sapiens	Galanin	-		2.7	2022-04-20	doi.org/10.1038/s41467-022-29072-3
	7XJJ	A	Peptide	Galanin	GAL₁	Homo sapiens	Galanin	-	Go/β1/γ2	3.3	2023-05-03	doi.org/10.1073/pnas.2121465119
	7XJJ (No Gprot)	A	Peptide	Galanin	GAL₁	Homo sapiens	Galanin	-		3.3	2023-05-03	doi.org/10.1073/pnas.2121465119

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WQ3_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.