psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G1	R:R:F282	4.52	No	Yes	0	0	4
2	L:L:S6	L:L:W2	6.18	No	Yes	0	0	0
3	L:L:L10	L:L:W2	3.42	No	Yes	1	0	0
4	L:L:W2	R:R:S281	8.65	Yes	No	0	0	3
5	L:L:W2	R:R:F282	8.02	Yes	Yes	0	0	4
6	L:L:W2	R:R:R285	3	Yes	Yes	1	0	4
7	L:L:S6	L:L:T3	4.8	No	No	0	0	0
8	L:L:L4	R:R:F186	4.87	No	Yes	0	0	4
9	L:L:N5	R:R:V95	2.96	No	No	0	0	4
10	L:L:N5	R:R:F186	8.46	No	Yes	0	0	4
11	L:L:G8	L:L:V16	5.52	No	No	0	0	0
12	L:L:G8	R:R:W188	8.44	No	Yes	0	0	5
13	L:L:Y9	R:R:Q92	11.27	No	No	0	0	6
14	L:L:Y9	R:R:V95	10.09	No	No	0	0	4
15	L:L:Y9	R:R:H112	11.98	No	No	0	0	5
16	L:L:L10	R:R:F275	12.18	No	Yes	0	0	1
17	L:L:L10	R:R:R285	15.79	No	Yes	1	0	4
18	L:L:A15	L:L:L11	4.73	No	No	0	0	0
19	L:L:L11	R:R:V274	2.98	No	No	0	0	3
20	L:L:G12	L:L:P13	4.06	No	No	0	0	0
21	L:L:P13	R:R:W188	12.16	No	Yes	0	0	5
22	R:R:N33	R:R:T36	8.77	No	Yes	0	5	5
23	R:R:F282	R:R:N33	4.83	Yes	No	0	4	5
24	R:R:L37	R:R:T36	5.9	No	Yes	0	5	5
25	R:R:I286	R:R:T36	3.04	No	Yes	0	4	5
26	R:R:A97	R:R:L37	4.73	No	No	0	4	5
27	R:R:I43	R:R:V39	3.07	No	No	0	7	5
28	R:R:F40	R:R:I286	6.28	Yes	No	0	6	4
29	R:R:F40	R:R:H289	3.39	Yes	Yes	1	6	5
30	R:R:F40	R:R:Y293	5.16	Yes	Yes	1	6	7
31	R:R:C290	R:R:I43	3.27	No	No	0	5	7
32	R:R:F44	R:R:I89	15.07	No	No	0	7	7
33	R:R:G47	R:R:L46	3.42	No	No	0	8	5
34	R:R:L46	R:R:S297	3	No	No	0	5	8
35	R:R:L82	R:R:V48	2.98	No	No	0	8	7
36	R:R:N51	R:R:S78	2.98	No	No	0	9	8
37	R:R:D81	R:R:N51	6.73	Yes	No	0	9	9
38	R:R:N51	R:R:P300	11.4	No	No	0	9	9
39	R:R:S78	R:R:V54	4.85	No	Yes	0	8	9
40	R:R:P300	R:R:V54	3.53	No	Yes	0	9	9
41	R:R:A304	R:R:V54	3.39	No	Yes	3	6	9
42	R:R:F305	R:R:V54	3.93	Yes	Yes	3	6	9
43	R:R:F310	R:R:V54	7.87	Yes	Yes	3	8	9
44	R:R:I55	R:R:L75	4.28	No	No	0	7	6
45	R:R:I55	R:R:S78	3.1	No	No	0	7	8
46	R:R:F310	R:R:V57	10.49	Yes	Yes	0	8	7
47	R:R:V57	R:R:Y314	3.79	Yes	No	0	7	5
48	R:R:L58	R:R:N71	5.49	No	No	0	7	8
49	R:R:L58	R:R:L75	5.54	No	No	0	7	6
50	R:R:F310	R:R:L58	6.09	Yes	No	0	8	7
51	R:R:N71	R:R:S68	5.96	No	No	0	8	7
52	R:R:D132	R:R:T69	5.78	No	No	0	8	6
53	R:R:A152	R:R:L72	3.15	No	No	0	7	5
54	R:R:A128	R:R:F73	5.55	No	Yes	0	7	7
55	R:R:F73	R:R:M129	7.46	Yes	Yes	0	7	8
56	R:R:D132	R:R:F73	7.17	No	Yes	0	8	7
57	R:R:I74	R:R:M129	5.83	No	Yes	1	8	8
58	R:R:I74	R:R:Y303	3.63	No	Yes	1	8	9
59	R:R:N76	R:R:T125	7.31	No	No	0	9	7
60	R:R:N76	R:R:V156	7.39	No	No	0	9	7
61	R:R:N76	R:R:W160	6.78	No	No	0	9	9
62	R:R:D81	R:R:L77	8.14	Yes	Yes	1	9	9
63	R:R:L77	R:R:S122	3	Yes	No	1	9	9
64	R:R:L126	R:R:L77	5.54	No	Yes	1	8	9
65	R:R:L77	R:R:M129	4.24	Yes	Yes	1	9	8
66	R:R:L77	R:R:N299	8.24	Yes	Yes	1	9	9
67	R:R:L77	R:R:Y303	4.69	Yes	Yes	1	9	9
68	R:R:A80	R:R:V121	3.39	No	No	0	8	7
69	R:R:D81	R:R:S122	7.36	Yes	No	1	9	9
70	R:R:D81	R:R:S296	10.31	Yes	No	1	9	9
71	R:R:D81	R:R:N299	8.08	Yes	Yes	1	9	9
72	R:R:L82	R:R:L86	5.54	No	No	0	8	5
73	R:R:L85	R:R:Y84	3.52	No	Yes	1	7	7
74	R:R:F115	R:R:Y84	12.38	No	Yes	0	5	7
75	R:R:S118	R:R:Y84	7.63	No	Yes	0	8	7
76	R:R:M119	R:R:Y84	3.59	No	Yes	1	7	7
77	R:R:W260	R:R:Y84	6.75	Yes	Yes	1	8	7
78	R:R:Y293	R:R:Y84	5.96	Yes	Yes	1	7	7
79	R:R:S296	R:R:Y84	7.63	No	Yes	1	9	7
80	R:R:L85	R:R:S296	7.51	No	No	1	7	9
81	R:R:F114	R:R:F87	8.57	No	No	0	5	5
82	R:R:C88	R:R:Q92	3.05	No	No	0	7	6
83	R:R:C88	R:R:F115	6.98	No	No	0	7	5
84	R:R:C88	R:R:Y293	6.72	No	Yes	0	7	7
85	R:R:I89	R:R:P90	3.39	No	No	0	7	8
86	R:R:I89	R:R:Y293	8.46	No	Yes	0	7	7
87	R:R:F91	R:R:W101	5.01	No	Yes	0	6	8
88	R:R:F91	R:R:I111	23.86	No	No	0	6	5
89	R:R:L98	R:R:T94	4.42	No	No	0	3	4
90	R:R:F282	R:R:Y96	8.25	Yes	No	0	4	4
91	R:R:R285	R:R:Y96	7.2	Yes	No	1	4	4
92	R:R:H289	R:R:Y96	9.8	Yes	No	1	5	4
93	R:R:Q184	R:R:T100	4.25	Yes	No	4	3	4
94	R:R:F186	R:R:T100	6.49	Yes	No	4	4	4
95	R:R:L103	R:R:W101	4.56	No	Yes	0	7	8
96	R:R:C108	R:R:W101	3.92	Yes	Yes	2	9	8
97	R:R:L176	R:R:W101	4.56	Yes	Yes	2	5	8
98	R:R:C187	R:R:W101	18.28	Yes	Yes	2	9	8
99	R:R:L103	R:R:V102	2.98	No	No	0	7	1
100	R:R:I107	R:R:L103	9.99	No	No	0	5	7
101	R:R:G104	R:R:L176	3.42	No	Yes	0	8	5
102	R:R:C108	R:R:Q174	4.58	Yes	Yes	2	9	4
103	R:R:C108	R:R:L176	3.17	Yes	Yes	2	9	5
104	R:R:C108	R:R:C187	7.28	Yes	Yes	2	9	9
105	R:R:F110	R:R:F114	9.65	No	No	0	4	5
106	R:R:H112	R:R:Q174	17.31	No	Yes	2	5	4
107	R:R:C187	R:R:H112	4.42	Yes	No	2	9	5
108	R:R:F114	R:R:Y113	5.16	No	Yes	0	5	5
109	R:R:V117	R:R:Y113	7.57	No	Yes	5	5	5
110	R:R:I164	R:R:Y113	9.67	No	Yes	0	4	5
111	R:R:A167	R:R:Y113	9.34	No	Yes	5	6	5
112	R:R:A171	R:R:Y113	4	No	Yes	0	5	5
113	R:R:T116	R:R:V170	9.52	No	No	0	5	4
114	R:R:S163	R:R:V117	9.7	No	No	0	8	5
115	R:R:A167	R:R:V117	3.39	No	No	5	6	5
116	R:R:M119	R:R:W260	9.31	No	Yes	1	7	8
117	R:R:F124	R:R:L120	4.87	No	No	0	5	6
118	R:R:L120	R:R:M166	5.65	No	No	0	6	5
119	R:R:V121	R:R:W160	24.52	No	No	0	7	9
120	R:R:S163	R:R:V121	3.23	No	No	0	8	7
121	R:R:I123	R:R:P212	3.39	No	Yes	0	7	9
122	R:R:I123	R:R:W260	7.05	No	Yes	0	7	8
123	R:R:F124	R:R:I159	5.02	No	No	0	5	7
124	R:R:L126	R:R:N299	5.49	No	Yes	1	8	9
125	R:R:L126	R:R:Y303	9.38	No	Yes	1	8	9
126	R:R:A127	R:R:P212	3.74	No	Yes	0	7	9
127	R:R:M129	R:R:Y303	4.79	Yes	Yes	1	8	9
128	R:R:I216	R:R:S130	10.84	No	No	0	8	9
129	R:R:S130	R:R:Y220	10.17	No	Yes	0	9	9
130	R:R:C219	R:R:V131	3.42	No	No	0	7	5
131	R:R:R133	R:R:Y220	14.4	No	Yes	0	9	9
132	R:R:V138	R:R:Y134	8.83	No	Yes	6	7	8
133	R:R:H139	R:R:Y134	3.27	No	Yes	6	6	8
134	R:R:C219	R:R:Y134	6.72	No	Yes	0	7	8
135	R:R:K222	R:R:Y134	3.58	No	Yes	0	5	8
136	R:R:I137	R:R:V223	6.14	No	No	0	8	8
137	R:R:H139	R:R:V138	8.3	No	No	6	6	7
138	R:R:H226	R:R:V138	4.15	No	No	0	5	7
139	R:R:N151	R:R:V148	10.35	No	No	0	4	7
140	R:R:G157	R:R:V156	3.68	No	No	0	3	7
141	R:R:I164	R:R:S163	3.1	No	No	0	4	8
142	R:R:A165	R:R:M166	3.22	No	No	0	4	5
143	R:R:M166	R:R:Y200	5.99	No	No	0	5	5
144	R:R:P169	R:R:S168	7.13	No	No	0	6	4
145	R:R:P169	R:R:Y200	15.3	No	No	0	6	5
146	R:R:H173	R:R:Y172	10.89	No	No	0	5	4
147	R:R:H173	R:R:W191	24.33	No	Yes	0	5	5
148	R:R:C187	R:R:Q174	4.58	Yes	Yes	2	9	4
149	R:R:E189	R:R:Q174	8.92	No	Yes	2	4	4
150	R:R:L176	R:R:T185	7.37	Yes	No	0	5	3
151	R:R:F177	R:R:P179	7.22	No	No	0	2	2
152	R:R:F177	R:R:W188	9.02	No	Yes	0	2	5
153	R:R:F177	R:R:Q190	5.86	No	No	0	2	4
154	R:R:H178	R:R:T185	10.95	No	No	0	3	3
155	R:R:P179	R:R:Q184	4.74	No	Yes	4	2	3
156	R:R:F186	R:R:P179	5.78	Yes	No	4	4	2
157	R:R:N183	R:R:Q184	5.28	No	Yes	0	5	3
158	R:R:F186	R:R:Q184	12.88	Yes	Yes	4	4	3
159	R:R:F186	R:R:W188	11.02	Yes	Yes	0	4	5
160	R:R:E189	R:R:W191	3.27	No	Yes	2	4	5
161	R:R:E189	R:R:K197	8.1	No	Yes	2	4	4
162	R:R:K197	R:R:W191	20.89	Yes	Yes	2	4	5
163	R:R:W191	R:R:Y200	6.75	Yes	No	0	5	5
164	R:R:D193	R:R:P194	8.05	No	No	0	5	2
165	R:R:D193	R:R:R195	3.57	No	No	2	5	3
166	R:R:D193	R:R:H196	11.35	No	No	2	5	2
167	R:R:H196	R:R:R195	4.51	No	No	2	2	3
168	R:R:A199	R:R:R195	4.15	No	No	0	4	3
169	R:R:K197	R:R:V201	3.04	Yes	No	2	4	5
170	R:R:E271	R:R:K197	10.8	No	Yes	2	5	4
171	R:R:E271	R:R:K198	5.4	No	No	0	5	2
172	R:R:F272	R:R:K198	12.41	No	No	0	5	2
173	R:R:E271	R:R:V201	9.98	No	No	2	5	5
174	R:R:F205	R:R:V206	3.93	Yes	No	0	5	4
175	R:R:F205	R:R:Y209	4.13	Yes	Yes	7	5	8
176	R:R:F205	R:R:L210	3.65	Yes	No	0	5	4
177	R:R:F205	R:R:H264	9.05	Yes	No	7	5	7
178	R:R:F205	R:R:L268	6.09	Yes	No	0	5	5
179	R:R:F207	R:R:L211	3.65	No	No	0	5	5
180	R:R:G208	R:R:P212	4.06	No	Yes	0	6	9
181	R:R:L213	R:R:Y209	4.69	No	Yes	0	6	8
182	R:R:L261	R:R:Y209	10.55	No	Yes	0	6	8
183	R:R:H264	R:R:Y209	5.44	No	Yes	7	7	8
184	R:R:L210	R:R:L214	4.15	No	No	0	4	4
185	R:R:C217	R:R:L213	3.17	No	No	0	4	6
186	R:R:F256	R:R:L213	6.09	No	No	0	9	6
187	R:R:C217	R:R:V253	3.42	No	No	0	4	7
188	R:R:F218	R:R:K222	11.17	No	No	0	5	5
189	R:R:V249	R:R:Y220	11.36	No	Yes	0	7	9
190	R:R:K242	R:R:L224	7.05	No	No	0	6	5
191	R:R:H226	R:R:K230	17.03	No	No	0	5	5
192	R:R:K229	R:R:K230	8.62	No	No	0	4	5
193	R:R:L231	R:R:S238	7.51	No	No	0	3	4
194	R:R:E239	R:R:M234	5.41	No	No	0	2	4
195	R:R:S235	R:R:S238	6.52	No	No	0	4	4
196	R:R:A240	R:R:E239	3.02	No	No	0	4	2
197	R:R:K242	R:R:T245	3	No	No	0	6	7
198	R:R:A246	R:R:K242	3.21	No	No	0	6	6
199	R:R:I302	R:R:V251	3.07	No	No	0	8	6
200	R:R:V252	R:R:Y303	8.83	No	Yes	0	8	9
201	R:R:I258	R:R:V254	3.07	No	No	0	5	4
202	R:R:I302	R:R:V255	4.61	No	No	0	8	6
203	R:R:F256	R:R:G257	3.01	No	No	0	9	5
204	R:R:S259	R:R:W260	3.71	No	Yes	1	8	8
205	R:R:N295	R:R:S259	10.43	No	No	1	9	8
206	R:R:H263	R:R:W260	6.35	No	Yes	0	6	8
207	R:R:A292	R:R:W260	5.19	No	Yes	0	7	8
208	R:R:N295	R:R:W260	7.91	No	Yes	1	9	8
209	R:R:L291	R:R:P262	4.93	No	No	0	8	9
210	R:R:H263	R:R:H264	5.97	No	No	0	6	7
211	R:R:H263	R:R:H267	15.53	No	No	0	6	5
212	R:R:I266	R:R:R285	5.01	Yes	Yes	0	5	4
213	R:R:A288	R:R:I266	4.87	No	Yes	0	6	5
214	R:R:F275	R:R:W269	4.01	Yes	No	0	1	4
215	R:R:A270	R:R:F275	4.16	No	Yes	0	3	1
216	R:R:F275	R:R:S281	3.96	Yes	No	0	1	3
217	R:R:H289	R:R:R285	19.18	Yes	Yes	1	5	4
218	R:R:H289	R:R:Y293	13.07	Yes	Yes	1	5	7
219	R:R:L291	R:R:S294	3	No	No	0	8	5
220	R:R:N295	R:R:N299	12.26	No	Yes	1	9	9
221	R:R:S297	R:R:V298	3.23	No	No	0	8	7
222	R:R:I301	R:R:V298	4.61	No	No	0	6	7
223	R:R:F305	R:R:I301	3.77	Yes	No	0	6	6
224	R:R:I302	R:R:Y303	6.04	No	Yes	0	8	9
225	R:R:A304	R:R:F310	9.71	No	Yes	3	6	8
226	R:R:F305	R:R:F310	5.36	Yes	Yes	3	6	8
227	R:R:E308	R:R:R311	10.47	No	No	0	4	8
228	R:R:K312	R:R:Q316	6.78	No	No	0	4	4
229	R:R:L77	R:R:T125	2.95	Yes	No	0	9	7
230	R:R:L291	R:R:T287	2.95	No	No	0	8	5
231	L:L:A15	L:L:H14	2.93	No	No	0	0	0
232	R:R:K312	R:R:K315	2.87	No	No	0	4	6
233	R:R:Q316	R:R:V317	2.87	No	No	0	4	5
234	R:R:I55	R:R:L82	2.85	No	No	0	7	8
235	R:R:I79	R:R:L75	2.85	No	No	0	6	6
236	R:R:K232	R:R:N233	2.8	No	No	0	2	2
237	R:R:C290	R:R:F40	2.79	No	Yes	0	5	6
238	R:R:C203	R:R:F207	2.79	No	No	0	3	5
239	R:R:L49	R:R:L53	2.77	No	No	3	4	6
240	R:R:L227	R:R:L231	2.77	No	No	0	8	3
241	R:R:F310	R:R:S307	2.64	Yes	No	0	8	8
242	R:R:F272	R:R:V202	2.62	No	No	0	5	5
243	R:R:V223	R:R:Y134	2.52	No	Yes	0	8	8
244	R:R:V223	R:R:Y220	2.52	No	Yes	0	8	9
245	R:R:F284	R:R:I266	2.51	No	Yes	0	5	5
246	L:L:L11	R:R:F275	2.44	No	Yes	0	0	1
247	R:R:F73	R:R:L72	2.44	Yes	No	0	7	5
248	R:R:F124	R:R:L162	2.44	No	No	0	5	4
249	L:L:W2	R:R:L277	2.28	Yes	No	0	0	1
250	R:R:H196	R:R:W191	2.12	No	Yes	2	2	5
251	R:R:C108	R:R:G175	1.96	Yes	No	0	9	4
252	R:R:C158	R:R:G155	1.96	No	No	0	3	5
253	L:L:A7	L:L:G8	1.95	No	No	0	0	0
254	R:R:A288	R:R:P262	1.87	No	No	0	6	9
255	L:L:G17	L:L:V16	1.84	No	No	0	0	0
256	R:R:G155	R:R:I159	1.76	No	No	0	5	7
257	R:R:P99	R:R:T100	1.75	No	No	0	4	4
258	R:R:P276	R:R:T278	1.75	No	Yes	0	3	4
259	R:R:P279	R:R:T278	1.75	No	Yes	0	2	4
260	R:R:G50	R:R:L49	1.71	No	No	3	7	4
261	R:R:G50	R:R:L53	1.71	No	No	3	7	6
262	R:R:A83	R:R:S118	1.71	No	No	0	6	8
263	R:R:G155	R:R:L154	1.71	No	No	0	5	2
264	R:R:A313	R:R:V57	1.7	No	Yes	0	5	7
265	R:R:A280	R:R:T278	1.68	No	Yes	0	3	4
266	R:R:L98	R:R:P99	1.64	No	No	0	3	4
267	R:R:L211	R:R:P212	1.64	No	Yes	0	5	9
268	R:R:A171	R:R:K109	1.61	No	No	0	5	6
269	R:R:V38	R:R:V39	1.6	No	No	0	7	5
270	R:R:S68	R:R:T70	1.6	No	No	0	7	7
271	R:R:S241	R:R:T245	1.6	No	No	0	5	7
272	R:R:V249	R:R:V253	1.6	No	No	0	7	7
273	R:R:S281	R:R:T278	1.6	No	Yes	0	3	4
274	R:R:T36	R:R:V35	1.59	Yes	No	0	5	5
275	R:R:T56	R:R:V57	1.59	No	Yes	0	4	7
276	R:R:T245	R:R:V249	1.59	No	No	0	7	7
277	R:R:T248	R:R:V252	1.59	No	No	0	8	8
278	R:R:A105	R:R:L176	1.58	No	Yes	0	2	5
279	R:R:A127	R:R:L215	1.58	No	No	0	7	7
280	R:R:A136	R:R:D132	1.54	No	No	0	8	8
281	R:R:F40	R:R:G41	1.51	Yes	No	0	6	5
282	R:R:F44	R:R:G41	1.51	No	No	0	7	5
283	R:R:M119	R:R:T116	1.51	No	No	0	7	5
284	R:R:L42	R:R:V38	1.49	No	No	0	5	7
285	R:R:L250	R:R:V254	1.49	No	No	0	4	4
286	R:R:N309	R:R:S307	1.49	No	No	0	6	8
287	R:R:I265	R:R:I266	1.47	No	Yes	0	6	5
288	R:R:I137	R:R:L227	1.43	No	No	0	8	8
289	R:R:I286	R:R:L283	1.43	No	No	0	4	1
290	R:R:L224	R:R:N225	1.37	No	No	0	5	3
291	R:R:P192	R:R:W191	1.35	No	Yes	0	4	5
292	R:R:E239	R:R:K243	1.35	No	No	0	2	4
293	R:R:R150	R:R:V148	1.31	No	No	0	5	7
294	R:R:V135	R:R:Y134	1.26	No	Yes	0	5	8
295	R:R:F305	R:R:L53	1.22	Yes	No	3	6	6
296	R:R:F106	R:R:F110	1.07	No	No	0	1	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:W2	5.25833	6	1	0
2	R:R:T36	4.825	4	0	5
3	R:R:F40	3.826	5	1	6
4	R:R:V54	4.714	5	3	9
5	R:R:V57	4.3925	4	0	7
6	R:R:F73	5.655	4	0	7
7	R:R:L77	5.25714	7	1	9
8	R:R:D81	8.124	5	1	9
9	R:R:Y84	6.78	7	1	7
10	R:R:W101	7.266	5	2	8
11	R:R:C108	4.182	5	2	9
12	R:R:Y113	7.148	5	5	5
13	R:R:M129	5.58	4	1	8
14	R:R:Y134	4.36333	6	6	8
15	R:R:Q174	8.8475	4	2	4
16	R:R:L176	4.02	5	2	5
17	R:R:Q184	6.7875	4	4	3
18	R:R:F186	8.25	6	4	4
19	R:R:C187	8.64	4	2	9
20	R:R:W188	10.16	4	0	5
21	R:R:W191	9.785	6	2	5
22	R:R:K197	10.7075	4	2	4
23	R:R:F205	5.37	5	7	5
24	R:R:Y209	6.2025	4	7	8
25	R:R:P212	3.2075	4	0	9
26	R:R:Y220	9.6125	4	0	9
27	R:R:W260	6.61	7	1	8
28	R:R:I266	3.465	4	0	5
29	R:R:F275	5.35	5	0	1
30	R:R:T278	1.695	4	0	4
31	R:R:F282	6.405	4	0	4
32	R:R:R285	10.036	5	1	4
33	R:R:H289	11.36	4	1	5
34	R:R:Y293	7.874	5	1	7
35	R:R:N299	8.5175	4	1	9
36	R:R:Y303	6.22667	6	1	9
37	R:R:F305	3.57	4	3	6
38	R:R:F310	7.02667	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H289	R:R:Y293	25.4734	13.07	Yes	Yes	1	5	7
2	R:R:C88	R:R:Y293	56.9001	6.72	No	Yes	0	7	7
3	R:R:C88	R:R:Q92	100	3.05	No	No	0	7	6
4	L:L:Y9	R:R:Q92	99.0677	11.27	No	No	0	0	6
5	L:L:Y9	R:R:V95	31.6888	10.09	No	No	0	0	4
6	L:L:N5	R:R:V95	30.3389	2.96	No	No	0	0	4
7	L:L:N5	R:R:F186	28.9534	8.46	No	Yes	0	0	4
8	R:R:F186	R:R:W188	13.321	11.02	Yes	Yes	0	4	5
9	L:L:Y9	R:R:H112	74.2482	11.98	No	No	0	0	5
10	R:R:Y293	R:R:Y84	70.7326	5.96	Yes	Yes	1	7	7
11	R:R:S296	R:R:Y84	83.704	7.63	No	Yes	1	9	7
12	R:R:D81	R:R:S296	83.4968	10.31	Yes	No	1	9	9
13	R:R:D81	R:R:N51	68.7644	6.73	Yes	No	0	9	9
14	R:R:N51	R:R:S78	39.9696	2.98	No	No	0	9	8
15	R:R:S78	R:R:V54	26.8913	4.85	No	Yes	0	8	9
16	R:R:F305	R:R:V54	22.1391	3.93	Yes	Yes	3	6	9
17	R:R:F305	R:R:I301	12.5894	3.77	Yes	No	0	6	6
18	R:R:I301	R:R:V298	10.0838	4.61	No	No	0	6	7
19	R:R:N51	R:R:P300	27.8042	11.4	No	No	0	9	9
20	R:R:P300	R:R:V54	26.6647	3.53	No	Yes	0	9	9
21	R:R:I55	R:R:S78	12.4794	3.1	No	No	0	7	8
22	R:R:F310	R:R:V54	26.5579	7.87	Yes	Yes	3	8	9
23	R:R:F310	R:R:V57	10.1227	10.49	Yes	Yes	0	8	7
24	R:R:L58	R:R:N71	11.0097	5.49	No	No	0	7	8
25	R:R:D81	R:R:L77	38.2927	8.14	Yes	Yes	1	9	9
26	R:R:L77	R:R:M129	10.4496	4.24	Yes	Yes	1	9	8
27	R:R:L77	R:R:T125	28.8077	2.95	Yes	No	0	9	7
28	R:R:N76	R:R:T125	27.733	7.31	No	No	0	9	7
29	R:R:N76	R:R:W160	24.4699	6.78	No	No	0	9	9
30	R:R:W260	R:R:Y84	49.8754	6.75	Yes	Yes	1	8	7
31	R:R:N295	R:R:W260	21.7345	7.91	No	Yes	1	9	8
32	R:R:N295	R:R:N299	21.5726	12.26	No	Yes	1	9	9
33	R:R:D81	R:R:N299	12.2366	8.08	Yes	Yes	1	9	9
34	R:R:V121	R:R:W160	23.3693	24.52	No	No	0	7	9
35	R:R:F115	R:R:Y84	44.7282	12.38	No	Yes	0	5	7
36	R:R:C88	R:R:F115	44.4434	6.98	No	No	0	7	5
37	R:R:S163	R:R:V121	21.1486	3.23	No	No	0	8	7
38	R:R:S163	R:R:V117	10.605	9.7	No	No	0	8	5
39	R:R:C187	R:R:H112	25.4314	4.42	Yes	No	2	9	5
40	R:R:C187	R:R:W101	15.299	18.28	Yes	Yes	2	9	8
41	R:R:H112	R:R:Q174	47.6935	17.31	No	Yes	2	5	4
42	R:R:C108	R:R:Q174	10.4658	4.58	Yes	Yes	2	9	4
43	R:R:C108	R:R:L176	13.9167	3.17	Yes	Yes	2	9	5
44	R:R:E189	R:R:Q174	39.0308	8.92	No	Yes	2	4	4
45	R:R:E189	R:R:W191	29.3581	3.27	No	Yes	2	4	5
46	R:R:W191	R:R:Y200	17.2316	6.75	Yes	No	0	5	5
47	R:R:M166	R:R:Y200	13.1462	5.99	No	No	0	5	5
48	R:R:L120	R:R:M166	10.3299	5.65	No	No	0	6	5
49	R:R:I123	R:R:W260	11.314	7.05	No	Yes	0	7	8
50	R:R:H263	R:R:W260	55.6052	6.35	No	Yes	0	6	8
51	R:R:H263	R:R:H264	53.2679	5.97	No	No	0	6	7
52	R:R:H264	R:R:Y209	45.5343	5.44	No	Yes	7	7	8
53	R:R:L213	R:R:Y209	43.647	4.69	No	Yes	0	6	8
54	R:R:C217	R:R:L213	39.9372	3.17	No	No	0	4	6
55	R:R:C217	R:R:V253	38.6876	3.42	No	No	0	4	7
56	R:R:V249	R:R:V253	37.4316	1.6	No	No	0	7	7
57	R:R:V249	R:R:Y220	28.62	11.36	No	Yes	0	7	9
58	R:R:V223	R:R:Y220	23.4502	2.52	No	Yes	0	8	9
59	R:R:V223	R:R:Y134	15.4511	2.52	No	Yes	0	8	8
60	R:R:H289	R:R:R285	22.4175	19.18	Yes	Yes	1	5	4
61	R:R:F40	R:R:Y293	11.5471	5.16	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:G1	R:R:F282	4.52	0	No	Yes	0	4	0	1
L:L:W2	R:R:S281	8.65	1	Yes	No	0	3	0	1
L:L:W2	R:R:F282	8.02	1	Yes	Yes	0	4	0	1
L:L:W2	R:R:R285	3	1	Yes	Yes	0	4	0	1
L:L:L4	R:R:F186	4.87	0	No	Yes	0	4	0	1
L:L:N5	R:R:V95	2.96	0	No	No	0	4	0	1
L:L:N5	R:R:F186	8.46	0	No	Yes	0	4	0	1
L:L:G8	R:R:W188	8.44	0	No	Yes	0	5	0	1
L:L:Y9	R:R:Q92	11.27	0	No	No	0	6	0	1
L:L:Y9	R:R:V95	10.09	0	No	No	0	4	0	1
L:L:Y9	R:R:H112	11.98	0	No	No	0	5	0	1
L:L:L10	R:R:F275	12.18	1	No	Yes	0	1	0	1
L:L:L10	R:R:R285	15.79	1	No	Yes	0	4	0	1
L:L:L11	R:R:V274	2.98	0	No	No	0	3	0	1
L:L:P13	R:R:W188	12.16	0	No	Yes	0	5	0	1
R:R:F282	R:R:N33	4.83	0	Yes	No	4	5	1	2
R:R:C88	R:R:Q92	3.05	0	No	No	7	6	2	1
R:R:F282	R:R:Y96	8.25	0	Yes	No	4	4	1	2
R:R:R285	R:R:Y96	7.2	1	Yes	No	4	4	1	2
R:R:H289	R:R:Y96	9.8	1	Yes	No	5	4	2	2
R:R:Q184	R:R:T100	4.25	4	Yes	No	3	4	2	2
R:R:F186	R:R:T100	6.49	4	Yes	No	4	4	1	2
R:R:H112	R:R:Q174	17.31	2	No	Yes	5	4	1	2
R:R:C187	R:R:H112	4.42	2	Yes	No	9	5	2	1
R:R:C187	R:R:Q174	4.58	2	Yes	Yes	9	4	2	2
R:R:F177	R:R:P179	7.22	0	No	No	2	2	2	2
R:R:F177	R:R:W188	9.02	0	No	Yes	2	5	2	1
R:R:P179	R:R:Q184	4.74	4	No	Yes	2	3	2	2
R:R:F186	R:R:P179	5.78	4	Yes	No	4	2	1	2
R:R:F186	R:R:Q184	12.88	4	Yes	Yes	4	3	1	2
R:R:F186	R:R:W188	11.02	4	Yes	Yes	4	5	1	1
R:R:I266	R:R:R285	5.01	0	Yes	Yes	5	4	2	1
R:R:F275	R:R:W269	4.01	0	Yes	No	1	4	1	2
R:R:A270	R:R:F275	4.16	0	No	Yes	3	1	2	1
R:R:F275	R:R:S281	3.96	0	Yes	No	1	3	1	1
R:R:H289	R:R:R285	19.18	1	Yes	Yes	5	4	2	1
L:L:L11	R:R:F275	2.44	0	No	Yes	0	1	0	1
L:L:W2	R:R:L277	2.28	1	Yes	No	0	1	0	1
R:R:S281	R:R:T278	1.6	0	No	Yes	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XJJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.96
Number of Linked Nodes	266
Number of Links	296
Number of Hubs	38
Number of Links mediated by Hubs	153
Number of Communities	7
Number of Nodes involved in Communities	56
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	59793
Length Of Smallest Path	3
Average Path Length	14.7475
Length of Longest Path	31
Minimum Path Strength	1.465
Average Path Strength	7.05457
Maximum Path Strength	22.61
Minimum Path Correlation	0.7
Average Path Correlation	0.931024
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	52.2493
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.001
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • molecular function activator activity • signaling receptor binding • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • galanin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • galanin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 2 galanin receptor binding • type 1 galanin receptor binding • type 3 galanin receptor binding • positive regulation of cell communication • regulation of localization • positive regulation of steroid hormone secretion • regulation of system process • regulation of glucocorticoid secretion • localization • positive regulation of cortisol secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • regulation of biological quality • cortisol secretion • positive regulation of corticosteroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • positive regulation of lipid transport • lipid export from cell • regulation of cortisol secretion • positive regulation of multicellular organismal process • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of hormone secretion • transport • steroid hormone secretion • positive regulation of biological process • regulation of lipid transport • organic hydroxy compound transport • positive regulation of secretion by cell • hormone secretion • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • lipid localization • export from cell • positive regulation of lipid localization • endocrine process • positive regulation of transport • regulation of lipid localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • response to xenobiotic stimulus • neuropeptide signaling pathway • response to estrogen • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • regulation of developmental process • epidermis development • molting cycle process • regulation of hair cycle • catagen • hair cycle phase • positive regulation of hair follicle maturation • positive regulation of developmental process • regulation of timing of catagen • skin epidermis development • hair follicle development • positive regulation of timing of catagen • hair follicle maturation • regulation of hair follicle maturation • epithelium development • regulation of multicellular organismal development • biological phase • hair cycle • developmental maturation • tissue development • positive regulation of hair follicle development • skin development • anatomical structure maturation • molting cycle • regulation of hair follicle development • hair cycle process • behavior • feeding behavior • positive regulation of cation transmembrane transport • monoatomic ion transmembrane transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • positive regulation of large conductance calcium-activated potassium channel activity • monoatomic cation transmembrane transport • positive regulation of molecular function • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of monoatomic ion transport • positive regulation of cation channel activity • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • positive regulation of transporter activity • positive regulation of ion transmembrane transporter activity • regulation of monoatomic cation transmembrane transport • negative regulation of lymphocyte proliferation • regulation of leukocyte activation • negative regulation of biological process • regulation of cell activation • lymphocyte activation • negative regulation of lymphocyte activation • leukocyte proliferation • leukocyte activation • negative regulation of mononuclear cell proliferation • negative regulation of leukocyte proliferation • lymphocyte proliferation • negative regulation of cellular process • regulation of immune system process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • negative regulation of cell population proliferation • cell activation • negative regulation of cell activation • negative regulation of immune system process • regulation of cell population proliferation • mononuclear cell proliferation • immune system process • regulation of mononuclear cell proliferation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • regulation of lymphocyte activation • regulation of hormone metabolic process • steroid metabolic process • regulation of steroid metabolic process • regulation of lipid metabolic process • primary metabolic process • hormone metabolic process • regulation of primary metabolic process • glucocorticoid metabolic process • regulation of glucocorticoid metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • nervous system development • response to immobilization stress • response to stress • response to peptide hormone • response to insulin • parental behavior • reproductive process • multicellular organismal reproductive process • reproductive behavior • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • establishment of protein localization • nitrogen compound transport • protein localization to extracellular region • peptide secretion • amide transport • intracellular protein localization • establishment of protein localization to extracellular region • protein secretion • peptide transport • protein transport • peptide hormone secretion • insulin secretion • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal cell body • neuropeptide binding • peptide binding • amide binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47211
Sequence	>7XJJ_nogp_Chain_R N F V T L V V F G L I F A L G V L G N S L V I T V L A S T T N L F I L N L S I A D L A Y L L F C I P F Q A T V Y A L P T W V L G A F I C K F I H Y F F T V S M L V S I F T L A A M S V D R Y V A I V H S R V S R N A L L G V G C I W A L S I A M A S P V A Y H Q G L F H P R N Q T F C W E Q W P D P R H K K A Y V V C T F V F G Y L L P L L L I C F C Y A K V L N H L H K K L K N M S K K S E A S K K K T A Q T V L V V V V V F G I S W L P H H I I H L W A E F G V F P L T P A S F L F R I T A H C L A Y S N S S V N P I I Y A F L S E N F R K A Y K Q V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WQ3	A	Peptide	Galanin	GAL₁	Homo sapiens	Galanin	-	Gi1/β1/γ2	2.7	2022-04-20	doi.org/10.1038/s41467-022-29072-3
	7WQ3 (No Gprot)	A	Peptide	Galanin	GAL₁	Homo sapiens	Galanin	-		2.7	2022-04-20	doi.org/10.1038/s41467-022-29072-3
	7XJJ	A	Peptide	Galanin	GAL₁	Homo sapiens	Galanin	-	Go/β1/γ2	3.3	2023-05-03	doi.org/10.1073/pnas.2121465119
	7XJJ (No Gprot)	A	Peptide	Galanin	GAL₁	Homo sapiens	Galanin	-		3.3	2023-05-03	doi.org/10.1073/pnas.2121465119

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