Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F54 13.0665124
2R:R:M58 7.6045128
3R:R:D99 9.22754189
4R:R:L100 7.7454207
5R:R:W120 96165
6R:R:D124 7.69254166
7R:R:L135 3.85754106
8R:R:F140 5.3408
9R:R:L142 7.08754107
10R:R:L145 4.8454118
11R:R:R155 4.6775409
12R:R:I159 3.6375408
13R:R:Y165 8.1985158
14R:R:F188 6.2025108
15R:R:Y199 6.3145106
16R:R:V201 8.20254165
17R:R:W203 6.4945134
18R:R:P204 6.67254137
19R:R:T206 6.87254138
20R:R:W207 7.283336137
21R:R:F230 5.623336106
22R:R:F234 8.13254108
23R:R:C248 3.3125407
24R:R:N249 6.9354119
25R:R:W273 6.41404
26R:R:L291 3.49754119
27R:R:W295 4.785118
28R:R:P297 2.2409
29R:R:L299 5.985408
30R:R:I340 6.87254129
31R:R:D342 6.4485189
32R:R:Y346 7.48409
33A:A:R21 1.4354304
34A:A:F191 9.35754195
35A:A:H195 8.23754234
36A:A:F196 6.445247
37A:A:F199 5.37167645
38A:A:K210 8.2765149
39A:A:C214 4.34447
40A:A:F215 4.90833649
41A:A:W258 5.00167645
42A:A:F259 5.2785269
43A:A:I265 2.698508
44A:A:K317 1.90754277
45A:A:F336 5.64198
46B:B:L7 5.354288
47B:B:K15 7.4725426
48B:B:R22 8.162526
49B:B:D27 4.7725408
50B:B:I37 4.96432
51B:B:V40 3.778533
52B:B:I43 3.765403
53B:B:M45 3.55404
54B:B:T50 6.375493
55B:B:L51 7.115419
56B:B:H54 8.65667619
57B:B:M61 5.115416
58B:B:W63 6.804517
59B:B:R68 11.7725415
60B:B:L70 5.6175415
61B:B:V71 3.9775458
62B:B:D76 4.25419
63B:B:L79 3.71667657
64B:B:I81 3.93667657
65B:B:W82 8.60571719
66B:B:S84 3.7515
67B:B:Y85 12.515414
68B:B:N88 4.978517
69B:B:K89 5.72719
70B:B:H91 5.76455
71B:B:I93 4.626557
72B:B:L95 4.79558
73B:B:W99 7.876549
74B:B:M101 3.7525449
75B:B:Y105 4.72286756
76B:B:Y111 4.49504
77B:B:V112 4.31558
78B:B:I123 4.0775466
79B:B:Y124 5.17571756
80B:B:L126 4.394555
81B:B:E130 2.715403
82B:B:V133 5.025454
83B:B:L139 5.14669
84B:B:H142 6.81143769
85B:B:Y145 9.0754258
86B:B:F151 5.51333609
87B:B:L152 4.7525173
88B:B:I157 5.8875407
89B:B:T159 6.086569
90B:B:S160 5.2476
91B:B:D163 8.5275469
92B:B:C166 4.0475478
93B:B:L168 3.576176
94B:B:W169 9.665668
95B:B:Q176 6.82464
96B:B:F180 7.242577
97B:B:H183 5.72429779
98B:B:V187 5.1275479
99B:B:M188 4.04754148
100B:B:F199 5.36409
101B:B:V200 5.22426
102B:B:D205 5.505479
103B:B:K209 6.90167676
104B:B:L210 4.89525
105B:B:W211 8.675408
106B:B:D212 7.935429
107B:B:E215 8.74423
108B:B:C218 4.15475
109B:B:R219 6.894525
110B:B:Q220 5.89427
111B:B:H225 8.21167629
112B:B:D228 6.678336149
113B:B:I232 5.68628
114B:B:F234 5.585425
115B:B:F235 7.36667636
116B:B:P236 5.655437
117B:B:F241 5.53143726
118B:B:T243 6.452528
119B:B:D246 6.15149
120B:B:T249 6.1075426
121B:B:R251 7.225628
122B:B:F253 6.75667626
123B:B:Y264 5.71167605
124B:B:H266 7.675484
125B:B:I269 4.2325484
126B:B:F278 6.2975437
127B:B:R283 7.22857739
128B:B:Y289 7.61333687
129B:B:N293 5.1825485
130B:B:N295 6.8225486
131B:B:W297 5.27588
132B:B:D298 8.765439
133B:B:K301 9.064535
134B:B:R304 8.115485
135B:B:L308 7.75407
136B:B:H311 9.192599
137B:B:R314 13.16448
138B:B:V315 4.3925497
139B:B:L318 3.254506
140B:B:M325 4.675415
141B:B:W332 13.346549
142B:B:D333 5.5025499
143B:B:F335 6.438594
144B:B:L336 3.368517
145B:B:K337 6.988596
146B:B:I338 3.415415
147B:B:W339 7.784599
148G:G:R27 6.195428
149G:G:D48 8.322539
150G:G:L51 5.22167636
151G:G:N59 4.564519
152G:G:P60 7.8825419
153G:G:F61 4.91857718
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F54 R:R:P55 12.45085.78YesNo047
2R:R:P55 R:R:V110 12.18733.53NoNo078
3R:R:T206 R:R:V110 11.39489.52YesNo088
4R:R:F54 R:R:M58 13.23166.22YesYes1248
5R:R:I340 R:R:M58 16.89195.83YesYes1298
6R:R:I340 R:R:Q103 17.39715.49YesNo1298
7R:R:N66 R:R:Q103 18.18926.6NoNo098
8R:R:D99 R:R:N66 19.46865.39YesNo099
9R:R:D342 R:R:D99 18.09855.32YesYes1899
10R:R:D342 R:R:Y346 52.69094.6YesYes099
11R:R:M151 R:R:R155 60.0294.96NoYes099
12R:R:M151 R:R:Y346 57.83057.18NoYes099
13A:A:I344 R:R:P162 63.54365.08NoNo069
14A:A:I344 R:R:I159 63.35112.94NoYes068
15A:A:L348 R:R:I159 62.10565.71NoYes098
16A:A:L348 A:A:L353 61.91116.92NoNo097
17A:A:L353 R:R:R155 61.79936.07NoYes079
18B:B:L318 B:B:S275 95.62673YesNo068
19B:B:S275 B:B:T274 95.70923.2NoNo088
20B:B:R314 B:B:T274 95.79135.17YesNo088
21A:A:W258 B:B:R314 96.23684YesYes458
22A:A:I212 A:A:W258 50.23384.7NoYes085
23A:A:F259 A:A:I212 50.21636.28YesNo098
24A:A:F259 A:A:I221 1006.28YesNo2698
25A:A:F223 A:A:I221 99.96312.51NoNo098
26A:A:F223 A:A:L39 99.25183.65NoNo099
27A:A:L39 A:A:V201 99.13212.98NoNo099
28A:A:D200 A:A:V201 76.05894.38NoNo099
29A:A:D200 A:A:L38 75.71745.43NoNo098
30A:A:L38 A:A:M198 75.54624.24NoNo087
31A:A:L36 A:A:M198 75.20284.24NoNo077
32A:A:F196 A:A:L36 68.06913.65YesNo077
33A:A:F196 A:A:L194 67.14143.65YesNo074
34A:A:L194 R:R:H163 66.9556.43NoNo046
35R:R:H163 R:R:P162 66.76813.05NoNo069
36A:A:N256 A:A:W258 50.23227.91NoYes085
37A:A:F259 A:A:N256 50.21474.83YesNo098
38R:R:I147 R:R:L95 34.71485.71NoNo079
39R:R:F188 R:R:L142 11.11193.65YesYes1087
40R:R:F146 R:R:L142 33.53252.44NoYes067
41R:R:F146 R:R:V181 34.24285.24NoNo066
42R:R:I147 R:R:V181 34.47894.61NoNo076
43R:R:F234 R:R:L142 13.168519.49YesYes1087
44R:R:L242 R:R:L299 16.20442.77NoYes088
45R:R:L242 R:R:L291 12.02634.15NoYes1189
46G:G:F61 G:G:N59 33.07513.62YesYes189
47B:B:N340 G:G:N59 44.35915.45NoYes099
48B:B:M45 B:B:N340 45.27482.8YesNo049
49B:B:L308 B:B:M45 47.0054.24YesYes074
50B:B:C294 B:B:L308 45.38246.35NoYes057
51B:B:C294 B:B:L318 44.51043.17NoYes056
52A:A:I222 A:A:I265 10.07792.94NoYes078
53A:A:I222 A:A:L36 10.61045.71NoNo077
54B:B:R68 B:B:S84 11.12452.64YesYes155
55B:B:S84 G:G:F61 12.89755.28YesYes158
56B:B:R68 B:B:Y85 24.038827.78YesYes154
57B:B:Y85 G:G:F61 10.95497.22YesYes148
58B:B:Y85 G:G:P60 13.525512.52YesYes149
59G:G:N59 G:G:P60 11.09466.52YesYes199
60B:B:V112 B:B:Y124 10.22193.79YesYes586
61B:B:V112 B:B:Y105 16.81092.52YesYes586
62B:B:L69 B:B:Y105 29.99517.03NoYes056
63B:B:D66 B:B:L69 30.58698.14NoNo085
64B:B:D66 B:B:R68 31.17833.57NoYes085
65A:A:R208 A:A:V201 39.99876.54NoNo099
66A:A:W211 B:B:Y145 39.54318.68NoYes098
67A:A:R208 A:A:W211 39.771618.99NoNo099
68B:B:I37 B:B:T34 31.43536.08YesNo025
69B:B:I37 B:B:R283 31.73693.76YesYes329
70B:B:R283 G:G:L51 51.93737.29YesYes396
71B:B:L284 G:G:L51 46.50682.77NoYes056
72B:B:L284 B:B:V296 47.66284.47NoNo055
73B:B:L286 B:B:V296 46.332.98NoNo075
74B:B:L286 B:B:L318 46.43284.15NoYes076
75B:B:L30 B:B:T34 21.81735.9NoNo055
76B:B:L30 B:B:M262 17.235.65NoNo054
77B:B:C148 B:B:L190 23.46584.76NoNo065
78B:B:L190 B:B:S160 29.34396.01NoYes056
79B:B:S147 B:B:S160 38.39584.89NoYes096
80B:B:S147 B:B:Y145 38.62592.54NoYes098
81B:B:C149 B:B:I157 14.54843.27NoYes087
82B:B:C149 B:B:T102 22.4665.07NoNo088
83B:B:C148 B:B:T102 22.71673.38NoNo068
84B:B:G244 B:B:T243 21.15821.82NoYes058
85B:B:G244 B:B:I273 22.9133.53NoNo056
86B:B:C250 B:B:I273 22.94366.55NoNo086
87B:B:C250 B:B:Y264 23.37854.03NoYes085
88B:B:M262 B:B:Y264 16.82045.99NoYes045
89B:B:L285 B:B:Y264 17.12484.69NoYes065
90B:B:F278 B:B:L285 17.290910.96YesNo376
91B:B:F235 B:B:F278 17.51018.57YesYes367
92B:B:F235 G:G:C41 21.91882.79YesNo367
93B:B:R283 G:G:C41 22.08052.79YesNo397
94B:B:W297 B:B:Y264 10.08378.68YesYes085
95R:R:D342 R:R:L95 33.305513.57YesNo1899
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WU9
Class A
SubFamily Lipid
Type Prostanoid
SubType EP3
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.38
Date 2022-08-17
D.O.I. 10.1016/j.celrep.2022.111323
Net Summary
Imin 2.51
Number of Linked Nodes 762
Number of Links 938
Number of Hubs 153
Number of Links mediated by Hubs 565
Number of Communities 30
Number of Nodes involved in Communities 249
Number of Links involved in Communities 372
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 911402
Length Of Smallest Path 3
Average Path Length 34.3702
Length of Longest Path 69
Minimum Path Strength 1.12
Average Path Strength 5.32434
Maximum Path Strength 26.94
Minimum Path Correlation 0.7
Average Path Correlation 0.978317
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 43.176
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.5464
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP43115
Sequence
>7WU9_Chain_R
SVSVAFPIT MLLTGFVGN ALAMLLVSR SYRRRKRKK SFLLCIGWL 
ALTDLVGQL LTTPVVIVV YLSKWEHID PSGRLCTFF GLTMTVFGL 
SSLFIASAM AVERALAIR APHWYASHM KTRITRAVL LGVWLASLA 
FALLPVLGV GQYTVQWPG TWCFISTGN LFFASAFAF LGLLALTVT 
FSCNLATIK ALVDRCRAK ATSAQWGRI TTETAIQLM GIMLVLSVC 
WSPLLIMML KMIFQKECN FFLIAVRLA SLNQILDPW VYLLLRKIL 
LRKF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7WU9_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GTGIVETHF 
TFKDLHFKM FDVERKKWI HCFEGVTAI IFCVLFDSI CNNKWFTDT 
SIILFLNKE IYTHFTCAT DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WU9_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WU9_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6AK3ALipidProstanoidEP3Homo sapiensDinoprostone IPGE2--2.92018-12-0510.1038/s41589-018-0171-8
6M9TALipidProstanoidEP3Homo sapiensMisoprostol-FA--2.52018-12-0510.1038/s41589-018-0160-y
8GDCALipidProstanoidEP3Homo sapiensPGE2-Gi1/&β;1/&γ;23.52024-01-0310.1073/pnas.2216329120
6AK3 (Dimer)ALipidProstanoidEP3Homo sapiensDinoprostone IPGE2--2.92018-12-0510.1038/s41589-018-0171-8




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WU9.zip



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