psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:P55	7.37	Yes	Yes	1	0	7
2	L:L:?1	R:R:M58	12.69	Yes	Yes	1	0	8
3	L:L:?1	R:R:Q103	21.9	Yes	No	1	0	8
4	L:L:?1	R:R:T106	3.31	Yes	No	1	0	6
5	L:L:?1	R:R:T107	7.72	Yes	Yes	0	0	8
6	L:L:?1	R:R:M137	14.8	Yes	Yes	1	0	7
7	L:L:?1	R:R:G141	2.56	Yes	No	0	0	7
8	L:L:?1	R:R:W207	6.81	Yes	Yes	1	0	7
9	L:L:?1	R:R:F209	2.73	Yes	No	1	0	8
10	L:L:?1	R:R:W295	3.41	Yes	Yes	1	0	8
11	L:L:?1	R:R:R333	10.9	Yes	Yes	1	0	8
12	L:L:?1	R:R:S336	17.96	Yes	No	1	0	8
13	R:R:F54	R:R:M58	3.73	No	Yes	1	4	8
14	R:R:F54	R:R:R333	3.21	No	Yes	1	4	8
15	R:R:P55	R:R:V110	3.53	Yes	Yes	1	7	8
16	R:R:I111	R:R:P55	3.39	Yes	Yes	0	7	7
17	R:R:P55	R:R:Y114	4.17	Yes	Yes	1	7	8
18	R:R:I111	R:R:I56	2.94	Yes	No	0	7	4
19	R:R:M58	R:R:R333	2.48	Yes	Yes	1	8	8
20	R:R:I340	R:R:M58	4.37	Yes	Yes	0	9	8
21	R:R:L59	R:R:T107	8.84	No	Yes	0	7	8
22	R:R:G62	R:R:I340	3.53	No	Yes	0	9	9
23	R:R:G65	R:R:W344	5.63	No	No	0	9	8
24	R:R:D99	R:R:N66	13.46	No	No	0	9	9
25	R:R:L100	R:R:N66	2.75	No	No	0	7	9
26	R:R:N66	R:R:P343	16.29	No	No	0	9	9
27	R:R:L348	R:R:L68	2.77	Yes	No	3	8	5
28	R:R:R75	R:R:S76	5.27	No	No	0	5	7
29	R:R:S87	R:R:Y165	2.54	No	Yes	0	6	8
30	R:R:F88	R:R:L89	3.65	No	No	0	8	8
31	R:R:F88	R:R:I92	5.02	No	Yes	0	8	8
32	R:R:F88	R:R:M151	2.49	No	No	0	8	9
33	R:R:L90	R:R:W94	19.36	No	Yes	0	6	8
34	R:R:L90	R:R:T174	2.95	No	No	0	6	6
35	R:R:C91	R:R:I147	3.27	No	No	0	7	7
36	R:R:C91	R:R:M151	3.24	No	No	0	7	9
37	R:R:C91	R:R:L178	4.76	No	Yes	0	7	7
38	R:R:I92	R:R:L347	7.14	Yes	No	0	8	9
39	R:R:R175	R:R:W94	6	No	Yes	0	5	8
40	R:R:L178	R:R:W94	4.56	Yes	Yes	0	7	8
41	R:R:I147	R:R:L95	14.27	No	No	0	7	9
42	R:R:D342	R:R:L95	12.21	Yes	No	0	9	9
43	R:R:F140	R:R:T98	2.59	Yes	No	0	8	9
44	R:R:S143	R:R:T98	4.8	No	No	0	7	9
45	R:R:D99	R:R:Q339	7.83	No	No	0	9	8
46	R:R:F140	R:R:V101	3.93	Yes	No	0	8	5
47	R:R:F140	R:R:G102	7.53	Yes	No	0	8	8
48	R:R:Q103	R:R:S336	2.89	No	No	1	8	8
49	R:R:F132	R:R:L105	3.65	No	No	0	4	6
50	R:R:L105	R:R:T136	2.95	No	Yes	0	6	5
51	R:R:F133	R:R:T106	7.78	Yes	No	1	6	6
52	R:R:T106	R:R:T136	4.71	No	Yes	1	6	5
53	R:R:P108	R:R:T107	3.5	No	Yes	0	8	8
54	R:R:I111	R:R:T107	3.04	Yes	Yes	0	7	8
55	R:R:V109	R:R:W120	2.45	No	Yes	0	6	5
56	R:R:V110	R:R:V113	3.21	Yes	Yes	1	8	7
57	R:R:V110	R:R:Y114	5.05	Yes	Yes	1	8	8
58	R:R:F133	R:R:V110	2.62	Yes	Yes	1	6	8
59	R:R:T206	R:R:V110	6.35	No	Yes	1	8	8
60	R:R:V113	R:R:Y114	5.05	Yes	Yes	1	7	8
61	R:R:V113	R:R:W120	2.45	Yes	Yes	1	7	5
62	R:R:T206	R:R:V113	3.17	No	Yes	1	8	7
63	R:R:T206	R:R:Y114	11.24	No	Yes	1	8	8
64	R:R:Q118	R:R:S116	2.89	No	No	0	3	4
65	R:R:I123	R:R:Q118	2.74	No	No	0	3	3
66	R:R:D124	R:R:W120	13.4	Yes	Yes	1	6	5
67	R:R:L129	R:R:W120	7.97	No	Yes	1	5	5
68	R:R:C130	R:R:W120	5.22	No	Yes	1	9	5
69	R:R:V201	R:R:W120	6.13	No	Yes	1	5	5
70	R:R:D124	R:R:I123	7	Yes	No	0	6	3
71	R:R:D124	R:R:L129	14.93	Yes	No	1	6	5
72	R:R:C130	R:R:V201	3.42	No	No	1	9	5
73	R:R:C130	R:R:C208	7.28	No	No	1	9	9
74	R:R:F133	R:R:T136	2.59	Yes	Yes	1	6	5
75	R:R:F133	R:R:M137	2.49	Yes	Yes	1	6	7
76	R:R:G134	R:R:Y199	7.24	No	Yes	0	7	6
77	R:R:L135	R:R:V139	5.96	No	Yes	0	6	7
78	R:R:A189	R:R:L135	3.15	No	No	0	8	6
79	R:R:L135	R:R:L190	2.77	No	No	0	6	6
80	R:R:F140	R:R:T136	5.19	Yes	Yes	0	8	5
81	R:R:F209	R:R:M137	8.71	No	Yes	1	8	7
82	R:R:M137	R:R:V332	3.04	Yes	No	0	7	7
83	R:R:T138	R:R:V139	3.17	No	Yes	0	7	7
84	R:R:T138	R:R:Y199	2.5	No	Yes	0	7	6
85	R:R:V139	R:R:W182	3.68	Yes	No	0	7	7
86	R:R:L186	R:R:V139	8.94	No	Yes	0	4	7
87	R:R:L142	R:R:V185	2.98	No	No	0	7	7
88	R:R:F234	R:R:L142	6.09	No	No	0	8	7
89	R:R:I147	R:R:S144	3.1	No	No	0	7	8
90	R:R:Q339	R:R:S144	8.66	No	No	0	8	8
91	R:R:D342	R:R:S144	2.94	Yes	No	0	9	8
92	R:R:A241	R:R:L145	3.15	No	No	0	7	8
93	R:R:L145	R:R:W295	14.81	No	Yes	0	8	8
94	R:R:F146	R:R:V181	5.24	No	No	0	6	6
95	R:R:F146	R:R:L237	3.65	No	No	0	6	5
96	R:R:A148	R:R:Y346	2.67	No	Yes	0	8	9
97	R:R:S149	R:R:V244	4.85	No	No	0	6	5
98	R:R:M151	R:R:Y346	4.79	No	Yes	0	9	9
99	R:R:L157	R:R:V153	2.98	No	No	0	6	6
100	R:R:C248	R:R:V153	5.12	Yes	No	0	7	6
101	R:R:E154	R:R:Y165	4.49	No	Yes	4	8	8
102	R:R:E154	R:R:M169	2.71	No	No	4	8	5
103	R:R:L284	R:R:R155	4.86	Yes	No	0	9	9
104	R:R:I287	R:R:R155	2.51	No	No	0	8	9
105	R:R:A255	R:R:R160	8.3	No	No	0	7	7
106	R:R:H168	R:R:W164	15.87	No	No	0	3	4
107	R:R:M169	R:R:Y165	7.18	No	Yes	4	5	8
108	R:R:H168	R:R:S167	9.76	No	No	0	3	4
109	R:R:T171	R:R:T174	3.14	No	No	0	4	6
110	R:R:L178	R:R:T174	4.42	Yes	No	0	7	6
111	R:R:F188	R:R:L191	3.65	Yes	No	2	8	7
112	R:R:F188	R:R:F230	16.08	Yes	Yes	2	8	6
113	R:R:A233	R:R:F188	2.77	No	Yes	0	5	8
114	R:R:L190	R:R:V193	8.94	No	No	0	6	4
115	R:R:F230	R:R:L191	4.87	Yes	No	2	6	7
116	R:R:P192	R:R:Y199	19.47	No	Yes	2	9	6
117	R:R:F230	R:R:P192	5.78	Yes	No	2	6	9
118	R:R:L194	R:R:V193	2.98	No	No	0	4	4
119	R:R:G197	R:R:N227	6.79	No	No	0	7	5
120	R:R:Q198	R:R:T200	2.83	No	No	5	2	4
121	R:R:Q198	R:R:S211	8.66	No	No	5	2	5
122	R:R:F230	R:R:Y199	7.22	Yes	Yes	2	6	6
123	R:R:S211	R:R:T200	6.4	No	No	5	5	4
124	R:R:C208	R:R:V201	3.42	No	No	1	9	5
125	R:R:Q202	R:R:W207	15.33	No	Yes	0	8	7
126	R:R:P204	R:R:W203	8.11	Yes	No	1	7	4
127	R:R:N326	R:R:W203	3.39	No	No	1	1	4
128	R:R:L329	R:R:W203	12.53	Yes	No	1	7	4
129	R:R:P204	R:R:W207	12.16	Yes	Yes	1	7	7
130	R:R:L329	R:R:P204	6.57	Yes	Yes	1	7	7
131	R:R:F209	R:R:W207	8.02	No	Yes	1	8	7
132	R:R:F328	R:R:W207	7.02	No	Yes	0	6	7
133	R:R:V332	R:R:W207	3.68	No	Yes	0	7	7
134	R:R:F230	R:R:I210	8.79	Yes	No	0	6	6
135	R:R:I306	R:R:L228	8.56	Yes	No	0	5	4
136	R:R:A231	R:R:I306	3.25	No	Yes	0	6	5
137	R:R:I306	R:R:S232	9.29	Yes	No	0	5	4
138	R:R:F234	R:R:M302	2.49	No	No	0	8	7
139	R:R:A235	R:R:L303	3.15	No	No	0	8	5
140	R:R:L239	R:R:L242	2.77	No	No	1	6	8
141	R:R:L239	R:R:L299	4.15	No	Yes	1	6	8
142	R:R:L240	R:R:V244	2.98	No	No	0	2	5
143	R:R:L242	R:R:L299	5.54	No	Yes	1	8	8
144	R:R:F246	R:R:T245	2.59	No	Yes	6	5	9
145	R:R:M288	R:R:T245	4.52	Yes	Yes	6	8	9
146	R:R:L291	R:R:T245	4.42	No	Yes	0	9	9
147	R:R:F246	R:R:M288	4.98	No	Yes	6	5	8
148	R:R:F246	R:R:S292	5.28	No	No	0	5	6
149	R:R:L284	R:R:N249	6.87	Yes	No	0	9	9
150	R:R:M288	R:R:N249	11.22	Yes	No	0	8	9
151	R:R:L256	R:R:W273	3.42	Yes	Yes	0	8	4
152	R:R:L256	R:R:T277	10.32	Yes	No	0	8	8
153	R:R:L256	R:R:T280	4.42	Yes	No	0	8	8
154	R:R:R261	R:R:V257	2.62	No	No	0	4	5
155	R:R:C260	R:R:W273	3.92	No	Yes	0	5	4
156	R:R:C260	R:R:T277	3.38	No	No	0	5	8
157	R:R:I276	R:R:W273	10.57	No	Yes	0	6	4
158	R:R:Q283	R:R:R350	15.19	No	No	0	8	8
159	R:R:I287	R:R:M288	2.92	No	Yes	0	8	8
160	R:R:I287	R:R:Y346	12.09	No	Yes	0	8	9
161	R:R:N338	R:R:V290	4.43	Yes	No	0	9	8
162	R:R:L291	R:R:N338	4.12	No	Yes	0	9	9
163	R:R:S292	R:R:S296	3.26	No	No	0	6	6
164	R:R:C294	R:R:V293	3.42	No	No	0	8	6
165	R:R:C294	R:R:N338	3.15	No	Yes	0	8	9
166	R:R:L298	R:R:W295	12.53	No	Yes	1	7	8
167	R:R:L299	R:R:W295	4.56	Yes	Yes	1	8	8
168	R:R:A335	R:R:W295	5.19	No	Yes	1	8	8
169	R:R:N338	R:R:W295	9.04	Yes	Yes	0	9	8
170	R:R:P297	R:R:S296	3.56	No	No	0	9	6
171	R:R:L334	R:R:P297	3.28	No	No	0	6	9
172	R:R:L298	R:R:L299	6.92	No	Yes	1	7	8
173	R:R:A335	R:R:L298	3.15	No	No	1	8	7
174	R:R:F328	R:R:M302	2.49	No	No	0	6	7
175	R:R:L329	R:R:N326	5.49	Yes	No	1	7	1
176	R:R:L329	R:R:R333	13.36	Yes	Yes	1	7	8
177	R:R:I330	R:R:L334	5.71	No	No	0	4	6
178	R:R:I340	R:R:L337	5.71	Yes	No	0	9	4
179	R:R:D342	R:R:N338	4.04	Yes	Yes	0	9	9
180	R:R:D342	R:R:Y346	6.9	Yes	Yes	0	9	9
181	R:R:P343	R:R:W344	4.05	No	No	0	9	8
182	R:R:L348	R:R:W344	7.97	Yes	No	0	8	8
183	R:R:I352	R:R:L348	4.28	No	Yes	0	6	8
184	R:R:I352	R:R:L353	7.14	No	No	0	6	7
185	R:R:F63	R:R:L100	2.44	No	No	0	7	7
186	R:R:H122	R:R:R119	2.26	No	No	0	3	4
187	R:R:F188	R:R:F234	2.14	Yes	No	0	8	8
188	R:R:G197	R:R:P192	2.03	No	No	0	7	9
189	R:R:G205	R:R:P204	2.03	No	Yes	0	6	7
190	R:R:C260	R:R:G274	1.96	No	No	0	5	5
191	R:R:A96	R:R:G93	1.95	No	No	0	9	6
192	R:R:A161	R:R:P162	1.87	No	No	0	4	9
193	R:R:G65	R:R:V64	1.84	No	No	0	9	4
194	R:R:A152	R:R:C248	1.81	No	Yes	0	9	7
195	R:R:A156	R:R:C248	1.81	No	Yes	0	6	7
196	R:R:P125	R:R:S126	1.78	No	No	0	4	4
197	R:R:G93	R:R:I92	1.76	No	Yes	0	6	8
198	R:R:C248	R:R:S247	1.72	Yes	No	0	7	3
199	R:R:G180	R:R:L183	1.71	No	No	0	2	3
200	R:R:G238	R:R:L299	1.71	No	Yes	0	7	8
201	R:R:C248	R:R:V244	1.71	Yes	No	0	7	5
202	R:R:G226	R:R:N227	1.7	No	No	0	1	5
203	R:R:A53	R:R:T57	1.68	No	No	0	4	4
204	R:R:A156	R:R:T252	1.68	No	No	0	6	9
205	R:R:M301	R:R:P297	1.68	Yes	No	0	5	9
206	R:R:G197	R:R:Q198	1.64	No	No	0	7	2
207	R:R:A231	R:R:I210	1.62	No	No	0	6	6
208	R:R:C289	R:R:M285	1.62	No	No	0	4	6
209	R:R:D124	R:R:P125	1.61	Yes	No	0	6	4
210	R:R:A173	R:R:M169	1.61	No	No	0	5	5
211	R:R:A331	R:R:M301	1.61	No	Yes	0	7	5
212	R:R:S87	R:R:T171	1.6	No	No	0	6	4
213	R:R:S149	R:R:T245	1.6	No	Yes	0	6	9
214	R:R:V181	R:R:V185	1.6	No	No	0	6	7
215	R:R:V290	R:R:V345	1.6	No	No	0	8	8
216	R:R:A67	R:R:L68	1.58	No	No	0	5	5
217	R:R:A150	R:R:L178	1.58	No	Yes	0	7	7
218	R:R:T57	R:R:T61	1.57	No	No	0	4	6
219	R:R:I92	R:R:V73	1.54	Yes	No	0	8	8
220	R:R:I111	R:R:V112	1.54	Yes	No	0	7	5
221	R:R:I253	R:R:V257	1.54	No	No	0	6	5
222	R:R:M70	R:R:S74	1.53	No	No	0	7	3
223	R:R:I340	R:R:T61	1.52	Yes	No	0	9	6
224	R:R:I159	R:R:T252	1.52	No	No	0	8	9
225	R:R:M305	R:R:T212	1.51	No	No	0	6	6
226	R:R:L89	R:R:S76	1.5	No	No	0	8	7
227	R:R:L60	R:R:V64	1.49	No	No	0	5	4
228	R:R:L178	R:R:V177	1.49	Yes	No	0	7	5
229	R:R:L97	R:R:T98	1.47	No	No	0	6	9
230	R:R:L284	R:R:T280	1.47	Yes	No	0	9	8
231	R:R:I300	R:R:M301	1.46	No	Yes	0	7	5
232	R:R:K304	R:R:M305	1.44	No	No	0	3	6
233	R:R:I253	R:R:L256	1.43	No	Yes	0	6	8
234	R:R:I253	R:R:L284	1.43	No	Yes	0	6	9
235	R:R:I306	R:R:L303	1.43	Yes	No	0	5	5
236	R:R:I340	R:R:L341	1.43	Yes	No	0	9	7
237	R:R:K351	R:R:L72	1.41	No	No	0	5	8
238	R:R:K86	R:R:L89	1.41	No	No	0	7	8
239	R:R:L68	R:R:L72	1.38	No	No	3	5	8
240	R:R:L348	R:R:L72	1.38	Yes	No	3	8	8
241	R:R:I276	R:R:Q272	1.37	No	No	0	6	3
242	R:R:A158	R:R:Y165	1.33	No	Yes	0	9	8
243	R:R:A161	R:R:W164	1.3	No	No	0	4	4
244	R:R:H122	R:R:Q118	1.24	No	No	0	3	3
245	R:R:F327	R:R:M301	1.24	No	Yes	0	3	5
246	R:R:F236	R:R:L237	1.22	No	No	0	4	5
247	R:R:Q283	R:R:R155	1.17	No	No	0	8	9
248	R:R:E121	R:R:R119	1.16	No	No	0	2	4
249	R:R:K263	R:R:W273	1.16	No	Yes	0	4	4
250	R:R:E279	R:R:R275	1.16	No	No	0	7	6
251	R:R:L179	R:R:W94	1.14	No	Yes	0	3	8
252	R:R:L157	R:R:W164	1.14	No	No	0	6	4
253	R:R:F132	R:R:R128	1.07	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.34667	12	1	0
2	R:R:P55	4.615	4	1	7
3	R:R:M58	5.8175	4	1	8
4	R:R:I92	3.865	4	0	8
5	R:R:W94	7.765	4	0	8
6	R:R:T107	5.775	4	0	8
7	R:R:V110	4.152	5	1	8
8	R:R:I111	2.7275	4	0	7
9	R:R:V113	3.47	4	1	7
10	R:R:Y114	6.3775	4	1	8
11	R:R:W120	6.27	6	1	5
12	R:R:D124	9.235	4	1	6
13	R:R:F133	3.87	4	1	6
14	R:R:T136	3.86	4	1	5
15	R:R:M137	7.26	4	1	7
16	R:R:V139	5.4375	4	0	7
17	R:R:F140	4.81	4	0	8
18	R:R:Y165	3.885	4	4	8
19	R:R:L178	3.362	5	0	7
20	R:R:F188	6.16	4	2	8
21	R:R:Y199	9.1075	4	2	6
22	R:R:P204	7.2175	4	1	7
23	R:R:W207	8.83667	6	1	7
24	R:R:F230	8.548	5	2	6
25	R:R:T245	3.2825	4	6	9
26	R:R:C248	2.434	5	0	7
27	R:R:L256	4.8975	4	0	8
28	R:R:W273	4.7675	4	0	4
29	R:R:L284	3.6575	4	0	9
30	R:R:M288	5.91	4	6	8
31	R:R:W295	8.25667	6	1	8
32	R:R:L299	4.576	5	1	8
33	R:R:M301	1.4975	4	0	5
34	R:R:I306	5.6325	4	0	5
35	R:R:L329	9.4875	4	1	7
36	R:R:R333	7.4875	4	1	8
37	R:R:N338	4.956	5	0	9
38	R:R:I340	3.312	5	0	9
39	R:R:D342	6.5225	4	0	9
40	R:R:Y346	6.6125	4	0	9
41	R:R:L348	4.1	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M58	11.4845	12.69	Yes	Yes	1	0	8
2	L:L:?1	R:R:P55	44.8424	7.37	Yes	Yes	1	0	7
3	R:R:P55	R:R:V110	20.899	3.53	Yes	Yes	1	7	8
4	R:R:P55	R:R:Y114	20.7301	4.17	Yes	Yes	1	7	8
5	L:L:?1	R:R:W295	97.9906	3.41	Yes	Yes	1	0	8
6	R:R:N338	R:R:W295	100	9.04	Yes	Yes	0	9	8
7	R:R:D342	R:R:N338	71.1025	4.04	Yes	Yes	0	9	9
8	R:R:D342	R:R:S144	28.6549	2.94	Yes	No	0	9	8
9	R:R:Q339	R:R:S144	18.7684	8.66	No	No	0	8	8
10	R:R:D99	R:R:Q339	17.7334	7.83	No	No	0	9	8
11	R:R:D99	R:R:N66	16.6898	13.46	No	No	0	9	9
12	R:R:N66	R:R:P343	13.5068	16.29	No	No	0	9	9
13	R:R:P343	R:R:W344	12.4285	4.05	No	No	0	9	8
14	R:R:D342	R:R:Y346	39.806	6.9	Yes	Yes	0	9	9
15	R:R:M151	R:R:Y346	25.0909	4.79	No	Yes	0	9	9
16	R:R:F88	R:R:M151	10.9302	2.49	No	No	0	8	9
17	R:R:D342	R:R:L95	12.238	12.21	Yes	No	0	9	9
18	R:R:I147	R:R:L95	11.3979	14.27	No	No	0	7	9
19	R:R:C91	R:R:I147	23.1682	3.27	No	No	0	7	7
20	R:R:C91	R:R:L178	35.3932	4.76	No	Yes	0	7	7
21	R:R:L178	R:R:T174	19.9073	4.42	Yes	No	0	7	6
22	R:R:T171	R:R:T174	15.5335	3.14	No	No	0	4	6
23	R:R:S87	R:R:T171	13.2687	1.6	No	No	0	6	4
24	R:R:I147	R:R:S144	13.5328	3.1	No	No	0	7	8
25	R:R:C91	R:R:M151	16.6594	3.24	No	No	0	7	9
26	L:L:?1	R:R:T106	12.5455	3.31	Yes	No	1	0	6
27	R:R:T106	R:R:T136	10.7267	4.71	No	Yes	1	6	5
28	R:R:V110	R:R:V113	19.7947	3.21	Yes	Yes	1	8	7
29	R:R:V113	R:R:W120	36.3892	2.45	Yes	Yes	1	7	5
30	R:R:V113	R:R:Y114	18.7511	5.05	Yes	Yes	1	7	8
31	R:R:D124	R:R:W120	20.925	13.4	Yes	Yes	1	6	5
32	R:R:D124	R:R:I123	14.0525	7	Yes	No	0	6	3
33	R:R:I123	R:R:Q118	11.7313	2.74	No	No	0	3	3
34	L:L:?1	R:R:W207	48.2981	6.81	Yes	Yes	1	0	7
35	R:R:F328	R:R:W207	44.1408	7.02	No	Yes	0	6	7
36	R:R:F328	R:R:M302	43.2877	2.49	No	No	0	6	7
37	R:R:F234	R:R:M302	42.4389	2.49	No	No	0	8	7
38	R:R:F188	R:R:F234	34.9125	2.14	Yes	No	0	8	8
39	R:R:F188	R:R:F230	31.6517	16.08	Yes	Yes	2	8	6
40	R:R:F230	R:R:Y199	13.6801	7.22	Yes	Yes	2	6	6
41	R:R:T138	R:R:Y199	11.6664	2.5	No	Yes	0	7	6
42	R:R:T138	R:R:V139	10.3889	3.17	No	Yes	0	7	7
43	R:R:L291	R:R:N338	35.5404	4.12	No	Yes	0	9	9
44	R:R:L291	R:R:T245	34.8129	4.42	No	Yes	0	9	9
45	R:R:S149	R:R:T245	16.1484	1.6	No	Yes	0	6	9
46	R:R:S149	R:R:V244	15.1957	4.85	No	No	0	6	5
47	R:R:C248	R:R:V244	13.2643	1.71	Yes	No	0	7	5
48	R:R:S87	R:R:Y165	10.9908	2.54	No	Yes	0	6	8
49	R:R:M288	R:R:T245	20.3447	4.52	Yes	Yes	6	8	9
50	R:R:M288	R:R:N249	18.5995	11.22	Yes	No	0	8	9
51	R:R:L284	R:R:N249	17.7551	6.87	Yes	No	0	9	9
52	R:R:I287	R:R:Y346	28.2002	12.09	No	Yes	0	8	9
53	R:R:I287	R:R:R155	22.904	2.51	No	No	0	8	9
54	R:R:L284	R:R:R155	20.4919	4.86	Yes	No	0	9	9
55	R:R:F246	R:R:S292	10.2157	5.28	No	No	0	5	6
56	R:R:I253	R:R:L284	20.0069	1.43	No	Yes	0	6	9
57	R:R:I253	R:R:L256	15.4686	1.43	No	Yes	0	6	8
58	R:R:L284	R:R:T280	16.7287	1.47	Yes	No	0	9	8
59	R:R:L256	R:R:T280	15.369	4.42	Yes	No	0	8	8
60	R:R:L256	R:R:W273	18.4479	3.42	Yes	Yes	0	8	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:P55	7.37	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M58	12.69	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Q103	21.9	1	Yes	No	0	8	0	1
L:L:?1	R:R:T106	3.31	1	Yes	No	0	6	0	1
L:L:?1	R:R:T107	7.72	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M137	14.8	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:G141	2.56	1	Yes	No	0	7	0	1
L:L:?1	R:R:W207	6.81	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F209	2.73	1	Yes	No	0	8	0	1
L:L:?1	R:R:W295	3.41	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:R333	10.9	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S336	17.96	1	Yes	No	0	8	0	1
R:R:F54	R:R:M58	3.73	1	No	Yes	4	8	2	1
R:R:F54	R:R:R333	3.21	1	No	Yes	4	8	2	1
R:R:P55	R:R:V110	3.53	1	Yes	Yes	7	8	1	2
R:R:I111	R:R:P55	3.39	0	Yes	Yes	7	7	2	1
R:R:P55	R:R:Y114	4.17	1	Yes	Yes	7	8	1	2
R:R:M58	R:R:R333	2.48	1	Yes	Yes	8	8	1	1
R:R:I340	R:R:M58	4.37	0	Yes	Yes	9	8	2	1
R:R:L59	R:R:T107	8.84	0	No	Yes	7	8	2	1
R:R:Q103	R:R:S336	2.89	1	No	No	8	8	1	1
R:R:F133	R:R:T106	7.78	1	Yes	No	6	6	2	1
R:R:T106	R:R:T136	4.71	1	No	Yes	6	5	1	2
R:R:P108	R:R:T107	3.5	0	No	Yes	8	8	2	1
R:R:I111	R:R:T107	3.04	0	Yes	Yes	7	8	2	1
R:R:V110	R:R:Y114	5.05	1	Yes	Yes	8	8	2	2
R:R:F133	R:R:V110	2.62	1	Yes	Yes	6	8	2	2
R:R:F133	R:R:T136	2.59	1	Yes	Yes	6	5	2	2
R:R:F133	R:R:M137	2.49	1	Yes	Yes	6	7	2	1
R:R:F209	R:R:M137	8.71	1	No	Yes	8	7	1	1
R:R:M137	R:R:V332	3.04	1	Yes	No	7	7	1	2
R:R:L145	R:R:W295	14.81	0	No	Yes	8	8	2	1
R:R:Q202	R:R:W207	15.33	0	No	Yes	8	7	2	1
R:R:P204	R:R:W207	12.16	1	Yes	Yes	7	7	2	1
R:R:L329	R:R:P204	6.57	1	Yes	Yes	7	7	2	2
R:R:F209	R:R:W207	8.02	1	No	Yes	8	7	1	1
R:R:F328	R:R:W207	7.02	0	No	Yes	6	7	2	1
R:R:V332	R:R:W207	3.68	0	No	Yes	7	7	2	1
R:R:L298	R:R:W295	12.53	1	No	Yes	7	8	2	1
R:R:L299	R:R:W295	4.56	1	Yes	Yes	8	8	2	1
R:R:A335	R:R:W295	5.19	1	No	Yes	8	8	2	1
R:R:N338	R:R:W295	9.04	0	Yes	Yes	9	8	2	1
R:R:L298	R:R:L299	6.92	1	No	Yes	7	8	2	2
R:R:A335	R:R:L298	3.15	1	No	No	8	7	2	2
R:R:L329	R:R:R333	13.36	1	Yes	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GDC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.45
Number of Linked Nodes	224
Number of Links	253
Number of Hubs	41
Number of Links mediated by Hubs	151
Number of Communities	6
Number of Nodes involved in Communities	50
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	38120
Length Of Smallest Path	3
Average Path Length	13.0363
Length of Longest Path	27
Minimum Path Strength	1.22
Average Path Strength	5.358
Maximum Path Strength	18.35
Minimum Path Correlation	0.7
Average Path Correlation	0.921861
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	45.3962
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.1094
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • prostaglandin E receptor activity • prostanoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • icosanoid receptor activity • prostaglandin receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • intestine smooth muscle contraction • gastro-intestinal system smooth muscle contraction • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • muscle system process • cell death • defense response • response to stress • inflammatory response • regulation of localization • transport • digestive system process • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of multicellular organismal process • negative regulation of digestive system process • regulation of gastric acid secretion • regulation of transport • secretion • acid secretion • regulation of digestive system process • establishment of localization • gastric acid secretion • regulation of secretion • digestion • negative regulation of multicellular organismal process • negative regulation of gastric acid secretion • acute-phase response • regulation of defense response • regulation of heat generation • regulation of response to external stimulus • homeostatic process • positive regulation of heat generation • positive regulation of biological process • positive regulation of acute inflammatory response • heat generation • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stress • positive regulation of fever generation • acute inflammatory response • fever generation • response to external stimulus • regulation of inflammatory response • multicellular organismal-level homeostasis • regulation of response to stimulus • positive regulation of defense response • temperature homeostasis • regulation of acute inflammatory response • positive regulation of multicellular organismal process • regulation of fever generation • organelle envelope • nuclear envelope
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P2E
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P2E
Name	Dinoprostone
Synonyms	Dinoprostona
Identifier
Formula	C20 H32 O5
Molecular Weight	352.465
SMILES
PubChem	5280360
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	57
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43115
Sequence	>8GDC_nogp_Chain_R V A F P I T M L L T G F V G N A L A M L L V S R S K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K Q R W E H I D P S G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A P H W Y A S H M K T R A T R A V L L G V W L A V L A F A L L P V L G V G Q Y T V Q W P G T W C F I S T G G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V S R C R A K A A Q W G R I T T E T A I Q L M G I M C V L S V C W S P L L I M M L K M I F C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GDC	A	Lipid	Prostanoid	EP₃	Homo sapiens	PGE2	-	Gi1/β1/γ2	3.5	2024-01-03	10.1073/pnas.2216329120
	8GDC (No Gprot)	A	Lipid	Prostanoid	EP₃	Homo sapiens	PGE2	-		3.5	2024-01-03	10.1073/pnas.2216329120
	7WU9	A	Lipid	Prostanoid	EP₃	Homo sapiens	-	-	Gi1/β1/γ2	3.38	2022-08-17	10.1016/j.celrep.2022.111323
	7WU9 (No Gprot)	A	Lipid	Prostanoid	EP₃	Homo sapiens	-	-		3.38	2022-08-17	10.1016/j.celrep.2022.111323
	6M9T	A	Lipid	Prostanoid	EP₃	Homo sapiens	Misoprostol-FA	-	-	2.5	2018-12-05	10.1038/s41589-018-0160-y
	6AK3	A	Lipid	Prostanoid	EP₃	Homo sapiens	Dinoprostone IPGE2	-	-	2.9	2018-12-05	10.1038/s41589-018-0171-8
	6AK3 (Multimeric)	A	Lipid	Prostanoid	EP₃	Homo sapiens	Dinoprostone IPGE2	-		2.9	2018-12-05	10.1038/s41589-018-0171-8

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