psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V50	R:R:W203	3.68	No	Yes	0	4	4
2	R:R:F54	R:R:S51	7.93	Yes	No	0	4	7
3	R:R:V52	R:R:Y114	13.88	No	No	0	5	8
4	R:R:F54	R:R:P55	2.89	Yes	No	1	4	7
5	R:R:F54	R:R:T57	3.89	Yes	No	0	4	4
6	R:R:F54	R:R:R333	5.34	Yes	No	1	4	8
7	R:R:P55	R:R:V110	3.53	No	No	1	7	8
8	R:R:P55	R:R:R333	8.65	No	No	1	7	8
9	R:R:M58	R:R:S336	3.07	No	No	0	8	8
10	R:R:L337	R:R:M58	2.83	No	No	2	4	8
11	R:R:I340	R:R:M58	8.75	Yes	No	2	9	8
12	R:R:F63	R:R:L59	9.74	No	No	0	7	7
13	R:R:L59	R:R:T107	14.74	No	No	0	7	8
14	R:R:G62	R:R:T61	1.82	Yes	No	2	9	6
15	R:R:I340	R:R:T61	7.6	Yes	No	2	9	6
16	R:R:G62	R:R:N66	1.7	Yes	Yes	2	9	9
17	R:R:G62	R:R:Q103	1.64	Yes	Yes	2	9	8
18	R:R:G62	R:R:I340	3.53	Yes	Yes	2	9	9
19	R:R:F63	R:R:L100	6.09	No	No	0	7	7
20	R:R:F63	R:R:L104	12.18	No	No	0	7	5
21	R:R:G65	R:R:V64	3.68	No	No	6	9	4
22	R:R:L68	R:R:V64	2.98	No	No	6	5	4
23	R:R:G65	R:R:L68	1.71	No	No	6	9	5
24	R:R:D99	R:R:N66	4.04	Yes	Yes	2	9	9
25	R:R:L100	R:R:N66	10.98	No	Yes	0	7	9
26	R:R:N66	R:R:P343	3.26	Yes	Yes	2	9	9
27	R:R:A69	R:R:M70	1.61	No	Yes	2	9	7
28	R:R:A69	R:R:A96	1.79	No	No	2	9	9
29	R:R:A69	R:R:P343	3.74	No	Yes	2	9	9
30	R:R:A96	R:R:M70	1.61	No	Yes	2	9	7
31	R:R:L97	R:R:M70	4.24	No	Yes	0	6	7
32	R:R:L100	R:R:M70	5.65	No	Yes	0	7	7
33	R:R:L71	R:R:R75	8.5	No	No	0	4	5
34	R:R:L347	R:R:L72	2.77	No	No	0	9	8
35	R:R:S74	R:R:V73	1.62	No	No	0	3	8
36	R:R:L89	R:R:V73	4.47	No	No	0	8	8
37	R:R:G93	R:R:V73	3.68	No	No	0	6	8
38	R:R:R78	R:R:Y77	23.66	No	No	0	4	6
39	R:R:K86	R:R:Y77	3.58	No	No	0	7	6
40	R:R:K83	R:R:R79	3.71	No	No	0	5	5
41	R:R:R79	R:R:R84	5.33	No	No	0	5	7
42	R:R:F88	R:R:K85	6.2	Yes	No	0	8	6
43	R:R:K85	R:R:L89	7.05	No	No	0	6	8
44	R:R:K86	R:R:T171	9.01	No	No	0	7	4
45	R:R:M169	R:R:S87	4.6	No	No	0	5	6
46	R:R:S87	R:R:T174	1.6	No	No	0	6	6
47	R:R:F88	R:R:I92	7.54	Yes	No	0	8	8
48	R:R:F88	R:R:M151	4.98	Yes	Yes	7	8	9
49	R:R:F88	R:R:R155	4.28	Yes	No	7	8	9
50	R:R:L90	R:R:T174	4.42	No	No	0	6	6
51	R:R:C91	R:R:M151	4.86	No	Yes	0	7	9
52	R:R:C91	R:R:L178	4.76	No	Yes	0	7	7
53	R:R:G93	R:R:I92	1.76	No	No	0	6	8
54	R:R:I92	R:R:Y346	3.63	No	Yes	0	8	9
55	R:R:T98	R:R:W94	6.06	No	No	0	9	8
56	R:R:L178	R:R:W94	4.56	Yes	No	0	7	8
57	R:R:L179	R:R:W94	7.97	No	No	0	3	8
58	R:R:D99	R:R:L95	2.71	Yes	No	2	9	9
59	R:R:I147	R:R:L95	5.71	No	No	0	7	9
60	R:R:D342	R:R:L95	12.21	Yes	No	2	9	9
61	R:R:A96	R:R:P343	1.87	No	Yes	2	9	9
62	R:R:S143	R:R:T98	1.6	No	No	0	7	9
63	R:R:D99	R:R:Q339	15.66	Yes	No	0	9	8
64	R:R:D342	R:R:D99	3.99	Yes	Yes	2	9	9
65	R:R:D99	R:R:P343	1.61	Yes	Yes	2	9	9
66	R:R:G102	R:R:V101	1.84	No	No	8	8	5
67	R:R:F140	R:R:V101	2.62	Yes	No	8	8	5
68	R:R:G102	R:R:L105	1.71	No	No	0	8	6
69	R:R:F140	R:R:G102	3.01	Yes	No	8	8	8
70	R:R:Q103	R:R:T107	2.83	Yes	No	0	8	8
71	R:R:Q103	R:R:S336	2.89	Yes	No	0	8	8
72	R:R:Q103	R:R:Q339	7.68	Yes	No	0	8	8
73	R:R:I340	R:R:Q103	2.74	Yes	Yes	2	9	8
74	R:R:L104	R:R:P108	1.64	No	No	0	5	8
75	R:R:L105	R:R:T136	4.42	No	No	0	6	5
76	R:R:F133	R:R:T106	9.08	No	No	0	6	6
77	R:R:P108	R:R:T107	5.25	No	No	0	8	8
78	R:R:V109	R:R:V113	1.6	No	Yes	1	6	7
79	R:R:V109	R:R:W120	3.68	No	Yes	1	6	5
80	R:R:F133	R:R:V109	23.6	No	No	0	6	6
81	R:R:V110	R:R:Y114	2.52	No	No	1	8	8
82	R:R:T206	R:R:V110	9.52	Yes	No	1	8	8
83	R:R:V112	R:R:W120	4.9	No	Yes	0	5	5
84	R:R:S116	R:R:V113	1.62	No	Yes	1	4	7
85	R:R:V113	R:R:W120	14.71	Yes	Yes	1	7	5
86	R:R:T206	R:R:V113	3.17	Yes	Yes	1	8	7
87	R:R:T206	R:R:Y114	2.5	Yes	No	1	8	8
88	R:R:S116	R:R:W120	3.71	No	Yes	1	4	5
89	R:R:I123	R:R:S116	10.84	No	No	1	3	4
90	R:R:I123	R:R:W120	9.4	No	Yes	1	3	5
91	R:R:L129	R:R:W120	4.56	No	Yes	0	5	5
92	R:R:V201	R:R:W120	4.9	Yes	Yes	1	5	5
93	R:R:E121	R:R:V201	7.13	No	Yes	0	2	5
94	R:R:D124	R:R:P125	4.83	No	No	0	6	4
95	R:R:D124	R:R:G127	1.68	No	No	0	6	3
96	R:R:D124	R:R:L129	10.86	No	No	0	6	5
97	R:R:G127	R:R:S126	3.71	No	No	0	3	4
98	R:R:R128	R:R:S126	11.86	No	No	0	2	4
99	R:R:C130	R:R:V201	3.42	No	Yes	1	9	5
100	R:R:C130	R:R:C208	5.46	No	No	1	9	9
101	R:R:L135	R:R:T131	4.42	Yes	No	3	6	5
102	R:R:T131	R:R:Y199	3.75	No	Yes	3	5	6
103	R:R:F132	R:R:L135	2.44	No	Yes	0	4	6
104	R:R:F133	R:R:W207	3.01	No	Yes	0	6	7
105	R:R:G134	R:R:Y199	10.14	No	Yes	0	7	6
106	R:R:A189	R:R:L135	3.15	No	Yes	0	8	6
107	R:R:L135	R:R:P192	4.93	Yes	Yes	3	6	9
108	R:R:L135	R:R:V193	2.98	Yes	No	0	6	4
109	R:R:L135	R:R:Y199	4.69	Yes	Yes	3	6	6
110	R:R:F188	R:R:T138	5.19	Yes	Yes	3	8	7
111	R:R:A189	R:R:T138	1.68	No	Yes	0	8	7
112	R:R:T138	R:R:Y199	4.99	Yes	Yes	3	7	6
113	R:R:F234	R:R:T138	5.19	No	Yes	3	8	7
114	R:R:F140	R:R:V139	3.93	Yes	Yes	0	8	7
115	R:R:S185	R:R:V139	6.46	Yes	Yes	0	7	7
116	R:R:L186	R:R:V139	8.94	No	Yes	0	4	7
117	R:R:A189	R:R:V139	3.39	No	Yes	0	8	7
118	R:R:G141	R:R:W295	2.81	No	Yes	0	7	8
119	R:R:F146	R:R:L142	10.96	No	No	0	6	7
120	R:R:L142	R:R:S185	7.51	No	Yes	0	7	7
121	R:R:S143	R:R:S185	3.26	No	Yes	0	7	7
122	R:R:A241	R:R:L145	4.73	No	Yes	0	7	8
123	R:R:L145	R:R:L242	2.77	Yes	No	0	8	8
124	R:R:L145	R:R:L291	2.77	Yes	No	0	8	9
125	R:R:L145	R:R:W295	9.11	Yes	Yes	0	8	8
126	R:R:F146	R:R:V181	5.24	No	No	0	6	6
127	R:R:I147	R:R:V181	4.61	No	No	0	7	6
128	R:R:S149	R:R:V244	3.23	No	No	0	6	5
129	R:R:M151	R:R:R155	6.2	Yes	No	7	9	9
130	R:R:M151	R:R:Y346	8.38	Yes	Yes	0	9	9
131	R:R:A152	R:R:T245	3.36	No	Yes	5	9	9
132	R:R:A152	R:R:C248	1.81	No	Yes	5	9	7
133	R:R:A152	R:R:N249	4.69	No	Yes	5	9	9
134	R:R:V153	R:R:V244	1.6	No	No	0	6	5
135	R:R:C248	R:R:V153	3.42	Yes	No	0	7	6
136	R:R:E154	R:R:Y165	6.73	No	No	0	8	8
137	R:R:Q283	R:R:R155	2.34	No	No	0	8	9
138	R:R:A156	R:R:C248	1.81	No	Yes	0	6	7
139	R:R:A156	R:R:T252	1.68	No	No	0	6	9
140	R:R:L157	R:R:W164	2.28	No	No	0	6	4
141	R:R:A158	R:R:Y165	6.67	No	No	0	9	8
142	R:R:A255	R:R:I159	1.62	No	No	0	7	8
143	R:R:I159	R:R:L256	4.28	No	No	0	8	8
144	R:R:A255	R:R:R160	4.15	No	No	0	7	7
145	R:R:A161	R:R:P162	1.87	No	No	0	4	9
146	R:R:A161	R:R:W164	6.48	No	No	0	4	4
147	R:R:H163	R:R:P162	3.05	No	No	0	6	9
148	R:R:H168	R:R:W164	17.98	No	No	0	3	4
149	R:R:M169	R:R:Y165	16.76	No	No	0	5	8
150	R:R:H168	R:R:S167	6.97	No	No	0	3	4
151	R:R:I173	R:R:K170	2.91	No	No	0	5	6
152	R:R:L179	R:R:R175	4.86	No	No	0	3	5
153	R:R:L178	R:R:V177	2.98	Yes	No	0	7	5
154	R:R:G180	R:R:L179	1.71	No	No	0	2	3
155	R:R:G180	R:R:L183	1.71	No	No	0	2	3
156	R:R:S185	R:R:V181	1.62	Yes	No	0	7	6
157	R:R:F188	R:R:L191	3.65	Yes	No	3	8	7
158	R:R:F188	R:R:F230	10.72	Yes	Yes	3	8	6
159	R:R:F188	R:R:F234	5.36	Yes	No	3	8	8
160	R:R:L190	R:R:L194	8.3	No	No	0	6	4
161	R:R:L191	R:R:P192	1.64	No	Yes	3	7	9
162	R:R:F230	R:R:L191	6.09	Yes	No	3	6	7
163	R:R:P192	R:R:Y199	6.95	Yes	Yes	3	9	6
164	R:R:F230	R:R:P192	5.78	Yes	Yes	3	6	9
165	R:R:G195	R:R:L194	1.71	No	No	0	6	4
166	R:R:G226	R:R:V196	1.84	No	No	0	1	4
167	R:R:F230	R:R:V196	2.62	Yes	No	0	6	4
168	R:R:G197	R:R:N227	1.7	No	Yes	0	7	5
169	R:R:F230	R:R:G197	6.02	Yes	No	0	6	7
170	R:R:Q198	R:R:S211	5.78	No	No	9	2	5
171	R:R:N227	R:R:Q198	5.28	Yes	No	9	5	2
172	R:R:I210	R:R:Y199	3.63	No	Yes	0	6	6
173	R:R:S211	R:R:T200	4.8	No	No	0	5	4
174	R:R:G205	R:R:V201	1.84	No	Yes	0	6	5
175	R:R:C208	R:R:V201	1.71	No	Yes	1	9	5
176	R:R:Q202	R:R:W207	15.33	No	Yes	1	8	7
177	R:R:F209	R:R:Q202	7.03	No	No	1	8	8
178	R:R:P204	R:R:W203	5.4	Yes	Yes	1	7	4
179	R:R:C325	R:R:W203	5.22	No	Yes	0	3	4
180	R:R:N326	R:R:W203	6.78	No	Yes	0	1	4
181	R:R:L329	R:R:W203	11.39	No	Yes	1	7	4
182	R:R:P204	R:R:T206	8.74	Yes	Yes	1	7	8
183	R:R:P204	R:R:W207	2.7	Yes	Yes	1	7	7
184	R:R:L329	R:R:P204	4.93	No	Yes	1	7	7
185	R:R:T206	R:R:W207	6.06	Yes	Yes	1	8	7
186	R:R:F209	R:R:W207	8.02	No	Yes	1	8	7
187	R:R:V332	R:R:W207	8.58	No	Yes	0	7	7
188	R:R:F209	R:R:F328	9.65	No	No	0	8	6
189	R:R:F230	R:R:I210	2.51	Yes	No	0	6	6
190	R:R:N227	R:R:S211	4.47	Yes	No	9	5	5
191	R:R:A231	R:R:T212	1.68	No	No	0	6	6
192	R:R:M305	R:R:T212	9.03	No	No	0	6	6
193	R:R:G226	R:R:L228	1.71	No	No	0	1	4
194	R:R:L228	R:R:N227	4.12	No	Yes	0	4	5
195	R:R:A231	R:R:M302	1.61	No	No	0	6	7
196	R:R:A231	R:R:I306	1.62	No	No	0	6	5
197	R:R:I306	R:R:S232	6.19	No	No	0	5	4
198	R:R:A235	R:R:M302	3.22	No	No	0	8	7
199	R:R:G238	R:R:L237	1.71	No	No	0	7	5
200	R:R:G238	R:R:L242	1.71	No	No	0	7	8
201	R:R:L239	R:R:T243	4.42	No	No	0	6	4
202	R:R:L239	R:R:L299	5.54	No	No	0	6	8
203	R:R:C248	R:R:T245	1.69	Yes	Yes	5	7	9
204	R:R:N249	R:R:T245	4.39	Yes	Yes	5	9	9
205	R:R:L291	R:R:T245	2.95	No	Yes	0	9	9
206	R:R:F246	R:R:L250	3.65	No	No	0	5	4
207	R:R:F246	R:R:M288	6.22	No	No	0	5	8
208	R:R:C248	R:R:N249	6.3	Yes	Yes	5	7	9
209	R:R:L284	R:R:N249	12.36	No	Yes	0	9	9
210	R:R:K254	R:R:L250	7.05	No	No	0	3	4
211	R:R:A251	R:R:K254	1.61	No	No	0	5	3
212	R:R:L284	R:R:T252	2.95	No	No	0	9	9
213	R:R:A281	R:R:I253	1.62	No	Yes	0	7	6
214	R:R:I253	R:R:L284	2.85	Yes	No	0	6	9
215	R:R:L256	R:R:T280	4.42	No	Yes	0	8	8
216	R:R:K263	R:R:R259	11.14	No	No	4	4	7
217	R:R:R259	R:R:W273	5	No	No	4	7	4
218	R:R:C260	R:R:G274	1.96	No	No	4	5	5
219	R:R:C260	R:R:T277	8.45	No	Yes	4	5	8
220	R:R:A262	R:R:K263	1.61	No	No	0	5	4
221	R:R:K263	R:R:W273	9.28	No	No	4	4	4
222	R:R:Q272	R:R:R275	2.34	No	No	0	3	6
223	R:R:T277	R:R:W273	2.43	Yes	No	4	8	4
224	R:R:G274	R:R:T277	3.64	No	Yes	4	5	8
225	R:R:E279	R:R:L353	2.65	No	No	0	7	7
226	R:R:A281	R:R:M285	3.22	No	No	0	7	6
227	R:R:G286	R:R:M285	1.75	No	No	0	5	6
228	R:R:I287	R:R:V345	3.07	No	No	0	8	8
229	R:R:I287	R:R:Y346	12.09	No	Yes	0	8	9
230	R:R:M288	R:R:S292	3.07	No	No	0	8	6
231	R:R:L289	R:R:V293	2.98	No	No	0	4	6
232	R:R:V290	R:R:V345	1.6	No	No	0	8	8
233	R:R:L291	R:R:N338	4.12	No	Yes	0	9	9
234	R:R:C294	R:R:W295	7.84	No	Yes	2	8	8
235	R:R:A335	R:R:C294	1.81	No	No	2	8	8
236	R:R:C294	R:R:N338	9.45	No	Yes	2	8	9
237	R:R:A335	R:R:W295	2.59	No	Yes	2	8	8
238	R:R:N338	R:R:W295	6.78	Yes	Yes	2	9	8
239	R:R:P297	R:R:S296	1.78	No	No	0	9	6
240	R:R:L298	R:R:P297	1.64	No	No	0	7	9
241	R:R:A331	R:R:P297	3.74	No	No	0	7	9
242	R:R:F328	R:R:M301	22.39	No	No	0	6	5
243	R:R:K304	R:R:Q322	4.07	No	No	0	3	1
244	R:R:E324	R:R:K304	5.4	No	No	0	3	3
245	R:R:M305	R:R:Q322	10.88	No	No	0	6	1
246	R:R:I330	R:R:L334	2.85	No	No	0	4	6
247	R:R:L334	R:R:L337	5.54	No	No	0	6	4
248	R:R:I340	R:R:L337	5.71	Yes	No	2	9	4
249	R:R:D342	R:R:N338	4.04	Yes	Yes	2	9	9
250	R:R:I340	R:R:L341	5.71	Yes	No	0	9	7
251	R:R:D342	R:R:P343	1.61	Yes	Yes	2	9	9
252	R:R:D342	R:R:Y346	5.75	Yes	Yes	0	9	9
253	R:R:L348	R:R:P343	1.64	No	Yes	0	8	9
254	R:R:L348	R:R:W344	28.47	No	No	0	8	8
255	R:R:L347	R:R:L348	4.15	No	No	0	9	8
256	R:R:L349	R:R:R350	10.93	No	No	0	7	8
257	R:R:I352	R:R:L349	5.71	No	No	0	6	7
258	R:R:L353	R:R:R350	8.5	No	No	0	7	8
259	R:R:K356	R:R:L353	4.23	No	No	0	5	7
260	R:R:L354	R:R:R355	8.5	No	No	0	7	5
261	R:R:A235	R:R:L299	1.58	No	No	0	8	8
262	R:R:T106	R:R:T136	1.57	No	No	0	6	5
263	R:R:T277	R:R:T280	1.57	Yes	Yes	0	8	8
264	R:R:I111	R:R:V112	1.54	No	No	0	7	5
265	R:R:I253	R:R:V257	1.54	Yes	No	0	6	5
266	R:R:I159	R:R:T252	1.52	No	No	0	8	9
267	R:R:I253	R:R:T280	1.52	Yes	Yes	0	6	8
268	R:R:I276	R:R:T280	1.52	No	Yes	0	6	8
269	R:R:L60	R:R:V64	1.49	No	No	0	5	4
270	R:R:L190	R:R:V193	1.49	No	No	0	6	4
271	R:R:L240	R:R:V244	1.49	No	No	0	2	5
272	R:R:I111	R:R:I56	1.47	No	No	0	7	4
273	R:R:L90	R:R:T171	1.47	No	No	0	6	4
274	R:R:D342	R:R:S144	1.47	Yes	No	0	9	8
275	R:R:L178	R:R:T174	1.47	Yes	No	0	7	6
276	R:R:I210	R:R:M137	1.46	No	No	0	6	7
277	R:R:Q272	R:R:S270	1.44	No	No	0	3	4
278	R:R:K304	R:R:M301	1.44	No	No	0	3	5
279	R:R:I253	R:R:L250	1.43	Yes	No	0	6	4
280	R:R:G65	R:R:W344	1.41	No	No	0	9	8
281	R:R:A331	R:R:F328	1.39	No	No	0	7	6
282	R:R:L71	R:R:L72	1.38	No	No	0	4	8
283	R:R:A264	R:R:R261	1.38	No	No	0	3	4
284	R:R:E279	R:R:I276	1.37	No	No	0	7	6
285	R:R:E324	R:R:K323	1.35	No	No	0	3	1
286	R:R:F229	R:R:S232	1.32	No	No	0	4	4
287	R:R:R261	R:R:T265	1.29	No	No	0	4	3
288	R:R:R275	R:R:T278	1.29	No	No	0	6	5
289	R:R:F327	R:R:M301	1.24	No	No	0	3	5
290	R:R:F357	R:R:R275	1.07	No	No	0	3	6
291	R:R:F140	R:R:W182	1	Yes	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F54	5.0125	4	1	4
2	R:R:G62	2.1725	4	2	9
3	R:R:N66	4.995	4	2	9
4	R:R:M70	3.2775	4	2	7
5	R:R:F88	5.75	4	7	8
6	R:R:D99	5.602	5	2	9
7	R:R:Q103	3.556	5	2	8
8	R:R:V113	5.275	4	1	7
9	R:R:W120	6.55143	7	1	5
10	R:R:L135	3.76833	6	3	6
11	R:R:T138	4.2625	4	3	7
12	R:R:V139	5.68	4	0	7
13	R:R:F140	2.64	4	8	8
14	R:R:L145	4.845	4	0	8
15	R:R:M151	6.105	4	7	9
16	R:R:L178	3.4425	4	0	7
17	R:R:S185	4.7125	4	0	7
18	R:R:F188	6.23	4	3	8
19	R:R:P192	4.825	4	3	9
20	R:R:Y199	5.69167	6	3	6
21	R:R:V201	3.8	5	1	5
22	R:R:W203	6.494	5	1	4
23	R:R:P204	5.4425	4	1	7
24	R:R:T206	5.998	5	1	8
25	R:R:W207	7.28333	6	1	7
26	R:R:N227	3.8925	4	9	5
27	R:R:F230	5.62333	6	3	6
28	R:R:T245	3.0975	4	5	9
29	R:R:C248	3.006	5	5	7
30	R:R:N249	6.935	4	5	9
31	R:R:I253	1.792	5	0	6
32	R:R:T277	4.0225	4	4	8
33	R:R:T280	2.2575	4	0	8
34	R:R:W295	5.826	5	2	8
35	R:R:N338	6.0975	4	2	9
36	R:R:I340	5.67333	6	2	9
37	R:R:D342	4.845	6	2	9
38	R:R:P343	2.28833	6	2	9
39	R:R:Y346	7.4625	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q103	R:R:Q339	13.7111	7.68	Yes	No	0	8	8
2	R:R:D99	R:R:Q339	14.8512	15.66	Yes	No	0	9	8
3	R:R:D99	R:R:L95	27.6936	2.71	Yes	No	2	9	9
4	R:R:I147	R:R:L95	87.6265	5.71	No	No	0	7	9
5	R:R:I147	R:R:V181	87.508	4.61	No	No	0	7	6
6	R:R:S185	R:R:V181	86.6295	1.62	Yes	No	0	7	6
7	R:R:S185	R:R:V139	100	6.46	Yes	Yes	0	7	7
8	R:R:F140	R:R:V139	75.6379	3.93	Yes	Yes	0	8	7
9	R:R:F140	R:R:G102	72.9579	3.01	Yes	No	8	8	8
10	R:R:G102	R:R:L105	72.4791	1.71	No	No	0	8	6
11	R:R:L105	R:R:T136	71.6598	4.42	No	No	0	6	5
12	R:R:T106	R:R:T136	70.7764	1.57	No	No	0	6	5
13	R:R:F133	R:R:T106	69.8929	9.08	No	No	0	6	6
14	R:R:F133	R:R:W207	48.275	3.01	No	Yes	0	6	7
15	R:R:G62	R:R:I340	10.3006	3.53	Yes	Yes	2	9	9
16	R:R:G62	R:R:N66	14.0023	1.7	Yes	Yes	2	9	9
17	R:R:D99	R:R:N66	15.7347	4.04	Yes	Yes	2	9	9
18	R:R:L348	R:R:P343	18.701	1.64	No	Yes	0	8	9
19	R:R:D99	R:R:P343	10.6461	1.61	Yes	Yes	2	9	9
20	R:R:D342	R:R:P343	25.5664	1.61	Yes	Yes	2	9	9
21	R:R:D342	R:R:L95	60.1254	12.21	Yes	No	2	9	9
22	R:R:I92	R:R:Y346	10.2019	3.63	No	Yes	0	8	9
23	R:R:D342	R:R:Y346	33.5077	5.75	Yes	Yes	0	9	9
24	R:R:M151	R:R:Y346	20.0286	8.38	Yes	Yes	0	9	9
25	R:R:C91	R:R:M151	17.4374	4.86	No	Yes	0	7	9
26	R:R:C91	R:R:L178	17.4078	4.76	No	Yes	0	7	7
27	R:R:L178	R:R:W94	16.0407	4.56	Yes	No	0	7	8
28	R:R:T98	R:R:W94	15.1523	6.06	No	No	0	9	8
29	R:R:S143	R:R:T98	15.784	1.6	No	No	0	7	9
30	R:R:S143	R:R:S185	16.855	3.26	No	Yes	0	7	7
31	R:R:L178	R:R:T174	14.6587	1.47	Yes	No	0	7	6
32	R:R:F133	R:R:V109	25.137	23.6	No	No	0	6	6
33	R:R:A189	R:R:L135	28.735	3.15	No	Yes	0	8	6
34	R:R:A189	R:R:V139	51.8385	3.39	No	Yes	0	8	7
35	R:R:A189	R:R:T138	22.2348	1.68	No	Yes	0	8	7
36	R:R:L135	R:R:P192	15.4533	4.93	Yes	Yes	3	6	9
37	R:R:F188	R:R:T138	14.9845	5.19	Yes	Yes	3	8	7
38	R:R:D342	R:R:N338	68.4764	4.04	Yes	Yes	2	9	9
39	R:R:L291	R:R:N338	58.0327	4.12	No	Yes	0	9	9
40	R:R:C248	R:R:T245	12.6795	1.69	Yes	Yes	5	7	9
41	R:R:L291	R:R:T245	53.5808	2.95	No	Yes	0	9	9
42	R:R:N249	R:R:T245	38.8085	4.39	Yes	Yes	5	9	9
43	R:R:L284	R:R:N249	38.6407	12.36	No	Yes	0	9	9
44	R:R:I253	R:R:T280	19.8312	1.52	Yes	Yes	0	6	8
45	R:R:I253	R:R:L284	32.2393	2.85	Yes	No	0	6	9
46	R:R:F188	R:R:F230	12.5463	10.72	Yes	Yes	3	8	6
47	R:R:F230	R:R:P192	13.0744	5.78	Yes	Yes	3	6	9
48	R:R:F230	R:R:G197	15.631	6.02	Yes	No	0	6	7
49	R:R:G197	R:R:N227	13.0497	1.7	No	Yes	0	7	5
50	R:R:F209	R:R:W207	31.9135	8.02	No	Yes	1	8	7
51	R:R:F209	R:R:F328	30.8524	9.65	No	No	0	8	6
52	R:R:A231	R:R:T212	13.3656	1.68	No	No	0	6	6
53	R:R:M305	R:R:T212	14.6538	9.03	No	No	0	6	6
54	R:R:M305	R:R:Q322	16.0802	10.88	No	No	0	6	1
55	R:R:K304	R:R:Q322	17.4967	4.07	No	No	0	3	1
56	R:R:K304	R:R:M301	21.682	1.44	No	No	0	3	5
57	R:R:F328	R:R:M301	24.2979	22.39	No	No	0	6	5
58	R:R:T206	R:R:W207	13.8295	6.06	Yes	Yes	1	8	7
59	R:R:D342	R:R:D99	13.7209	3.99	Yes	Yes	2	9	9
60	R:R:V109	R:R:W120	21.6524	3.68	No	Yes	1	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7WU9_nogp

PDB Summary
PDB	7WU9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.6
Number of Linked Nodes	249
Number of Links	291
Number of Hubs	39
Number of Links mediated by Hubs	145
Number of Communities	9
Number of Nodes involved in Communities	69
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	39227
Length Of Smallest Path	3
Average Path Length	14.7193
Length of Longest Path	39
Minimum Path Strength	1.18
Average Path Strength	5.02504
Maximum Path Strength	16.31
Minimum Path Correlation	0.7
Average Path Correlation	0.927843
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	48.4022
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.007
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43115
Sequence	>7WU9_nogp_Chain_R S V S V A F P I T M L L T G F V G N A L A M L L V S R S Y R R R K R K K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K W E H I D P S G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A P H W Y A S H M K T R I T R A V L L G V W L A S L A F A L L P V L G V G Q Y T V Q W P G T W C F I S T G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V D R C R A K A T S A Q W G R I T T E T A I Q L M G I M L V L S V C W S P L L I M M L K M I F Q K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I L L R K F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6AK3	A	Lipid	Prostanoid	EP₃	Homo sapiens	PGE2	-	-	2.9	2018-12-05	doi.org/10.1038/s41589-018-0171-8
	6M9T	A	Lipid	Prostanoid	EP₃	Homo sapiens	Misoprostol-FA	-	-	2.5	2018-12-05	doi.org/10.1038/s41589-018-0160-y
	7WU9	A	Lipid	Prostanoid	EP₃	Homo sapiens	-	-	Gi1/β1/γ2	3.38	2022-08-17	doi.org/10.1016/j.celrep.2022.111323
	7WU9 (No Gprot)	A	Lipid	Prostanoid	EP₃	Homo sapiens	-	-		3.38	2022-08-17	doi.org/10.1016/j.celrep.2022.111323
	8GDC	A	Lipid	Prostanoid	EP₃	Homo sapiens	PGE2	-	Gi1/β1/γ2	3.5	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GDC (No Gprot)	A	Lipid	Prostanoid	EP₃	Homo sapiens	PGE2	-		3.5	2024-01-03	doi.org/10.1073/pnas.2216329120

there is no ligand in network 7WU9_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.