psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V50	R:R:W203	3.68	No	Yes	0	4	4
2	R:R:F54	R:R:S51	7.93	Yes	No	0	4	7
3	R:R:V52	R:R:Y114	13.88	No	No	0	5	8
4	R:R:F54	R:R:P55	2.89	Yes	No	1	4	7
5	R:R:F54	R:R:T57	3.89	Yes	No	0	4	4
6	R:R:F54	R:R:R333	5.34	Yes	No	1	4	8
7	R:R:P55	R:R:V110	3.53	No	No	1	7	8
8	R:R:P55	R:R:R333	8.65	No	No	1	7	8
9	R:R:M58	R:R:S336	3.07	No	No	0	8	8
10	R:R:L337	R:R:M58	2.83	No	No	2	4	8
11	R:R:I340	R:R:M58	8.75	Yes	No	2	9	8
12	R:R:F63	R:R:L59	9.74	No	No	0	7	7
13	R:R:L59	R:R:T107	14.74	No	No	0	7	8
14	R:R:G62	R:R:T61	1.82	Yes	No	2	9	6
15	R:R:I340	R:R:T61	7.6	Yes	No	2	9	6
16	R:R:G62	R:R:N66	1.7	Yes	Yes	2	9	9
17	R:R:G62	R:R:Q103	1.64	Yes	Yes	2	9	8
18	R:R:G62	R:R:I340	3.53	Yes	Yes	2	9	9
19	R:R:F63	R:R:L100	6.09	No	No	0	7	7
20	R:R:F63	R:R:L104	12.18	No	No	0	7	5
21	R:R:G65	R:R:V64	3.68	No	No	6	9	4
22	R:R:L68	R:R:V64	2.98	No	No	6	5	4
23	R:R:G65	R:R:L68	1.71	No	No	6	9	5
24	R:R:D99	R:R:N66	4.04	Yes	Yes	2	9	9
25	R:R:L100	R:R:N66	10.98	No	Yes	0	7	9
26	R:R:N66	R:R:P343	3.26	Yes	Yes	2	9	9
27	R:R:A69	R:R:M70	1.61	No	Yes	2	9	7
28	R:R:A69	R:R:A96	1.79	No	No	2	9	9
29	R:R:A69	R:R:P343	3.74	No	Yes	2	9	9
30	R:R:A96	R:R:M70	1.61	No	Yes	2	9	7
31	R:R:L97	R:R:M70	4.24	No	Yes	0	6	7
32	R:R:L100	R:R:M70	5.65	No	Yes	0	7	7
33	R:R:L71	R:R:R75	8.5	No	No	0	4	5
34	R:R:L347	R:R:L72	2.77	No	No	0	9	8
35	R:R:S74	R:R:V73	1.62	No	No	0	3	8
36	R:R:L89	R:R:V73	4.47	No	No	0	8	8
37	R:R:G93	R:R:V73	3.68	No	No	0	6	8
38	R:R:R78	R:R:Y77	23.66	No	No	0	4	6
39	R:R:K86	R:R:Y77	3.58	No	No	0	7	6
40	R:R:K83	R:R:R79	3.71	No	No	0	5	5
41	R:R:R79	R:R:R84	5.33	No	No	0	5	7
42	R:R:F88	R:R:K85	6.2	Yes	No	0	8	6
43	R:R:K85	R:R:L89	7.05	No	No	0	6	8
44	R:R:K86	R:R:T171	9.01	No	No	0	7	4
45	R:R:M169	R:R:S87	4.6	No	No	0	5	6
46	R:R:S87	R:R:T174	1.6	No	No	0	6	6
47	R:R:F88	R:R:I92	7.54	Yes	No	0	8	8
48	R:R:F88	R:R:M151	4.98	Yes	Yes	7	8	9
49	R:R:F88	R:R:R155	4.28	Yes	No	7	8	9
50	R:R:L90	R:R:T174	4.42	No	No	0	6	6
51	R:R:C91	R:R:M151	4.86	No	Yes	0	7	9
52	R:R:C91	R:R:L178	4.76	No	Yes	0	7	7
53	R:R:G93	R:R:I92	1.76	No	No	0	6	8
54	R:R:I92	R:R:Y346	3.63	No	Yes	0	8	9
55	R:R:T98	R:R:W94	6.06	No	No	0	9	8
56	R:R:L178	R:R:W94	4.56	Yes	No	0	7	8
57	R:R:L179	R:R:W94	7.97	No	No	0	3	8
58	R:R:D99	R:R:L95	2.71	Yes	No	2	9	9
59	R:R:I147	R:R:L95	5.71	No	No	0	7	9
60	R:R:D342	R:R:L95	12.21	Yes	No	2	9	9
61	R:R:A96	R:R:P343	1.87	No	Yes	2	9	9
62	R:R:S143	R:R:T98	1.6	No	No	0	7	9
63	R:R:D99	R:R:Q339	15.66	Yes	No	0	9	8
64	R:R:D342	R:R:D99	3.99	Yes	Yes	2	9	9
65	R:R:D99	R:R:P343	1.61	Yes	Yes	2	9	9
66	R:R:G102	R:R:V101	1.84	No	No	8	8	5
67	R:R:F140	R:R:V101	2.62	Yes	No	8	8	5
68	R:R:G102	R:R:L105	1.71	No	No	0	8	6
69	R:R:F140	R:R:G102	3.01	Yes	No	8	8	8
70	R:R:Q103	R:R:T107	2.83	Yes	No	0	8	8
71	R:R:Q103	R:R:S336	2.89	Yes	No	0	8	8
72	R:R:Q103	R:R:Q339	7.68	Yes	No	0	8	8
73	R:R:I340	R:R:Q103	2.74	Yes	Yes	2	9	8
74	R:R:L104	R:R:P108	1.64	No	No	0	5	8
75	R:R:L105	R:R:T136	4.42	No	No	0	6	5
76	R:R:F133	R:R:T106	9.08	No	No	0	6	6
77	R:R:P108	R:R:T107	5.25	No	No	0	8	8
78	R:R:V109	R:R:V113	1.6	No	Yes	1	6	7
79	R:R:V109	R:R:W120	3.68	No	Yes	1	6	5
80	R:R:F133	R:R:V109	23.6	No	No	0	6	6
81	R:R:V110	R:R:Y114	2.52	No	No	1	8	8
82	R:R:T206	R:R:V110	9.52	Yes	No	1	8	8
83	R:R:V112	R:R:W120	4.9	No	Yes	0	5	5
84	R:R:S116	R:R:V113	1.62	No	Yes	1	4	7
85	R:R:V113	R:R:W120	14.71	Yes	Yes	1	7	5
86	R:R:T206	R:R:V113	3.17	Yes	Yes	1	8	7
87	R:R:T206	R:R:Y114	2.5	Yes	No	1	8	8
88	R:R:S116	R:R:W120	3.71	No	Yes	1	4	5
89	R:R:I123	R:R:S116	10.84	No	No	1	3	4
90	R:R:I123	R:R:W120	9.4	No	Yes	1	3	5
91	R:R:L129	R:R:W120	4.56	No	Yes	0	5	5
92	R:R:V201	R:R:W120	4.9	Yes	Yes	1	5	5
93	R:R:E121	R:R:V201	7.13	No	Yes	0	2	5
94	R:R:D124	R:R:P125	4.83	No	No	0	6	4
95	R:R:D124	R:R:G127	1.68	No	No	0	6	3
96	R:R:D124	R:R:L129	10.86	No	No	0	6	5
97	R:R:G127	R:R:S126	3.71	No	No	0	3	4
98	R:R:R128	R:R:S126	11.86	No	No	0	2	4
99	R:R:C130	R:R:V201	3.42	No	Yes	1	9	5
100	R:R:C130	R:R:C208	5.46	No	No	1	9	9
101	R:R:L135	R:R:T131	4.42	Yes	No	3	6	5
102	R:R:T131	R:R:Y199	3.75	No	Yes	3	5	6
103	R:R:F132	R:R:L135	2.44	No	Yes	0	4	6
104	R:R:F133	R:R:W207	3.01	No	Yes	0	6	7
105	R:R:G134	R:R:Y199	10.14	No	Yes	0	7	6
106	R:R:A189	R:R:L135	3.15	No	Yes	0	8	6
107	R:R:L135	R:R:P192	4.93	Yes	Yes	3	6	9
108	R:R:L135	R:R:V193	2.98	Yes	No	0	6	4
109	R:R:L135	R:R:Y199	4.69	Yes	Yes	3	6	6
110	R:R:F188	R:R:T138	5.19	Yes	Yes	3	8	7
111	R:R:A189	R:R:T138	1.68	No	Yes	0	8	7
112	R:R:T138	R:R:Y199	4.99	Yes	Yes	3	7	6
113	R:R:F234	R:R:T138	5.19	No	Yes	3	8	7
114	R:R:F140	R:R:V139	3.93	Yes	Yes	0	8	7
115	R:R:S185	R:R:V139	6.46	Yes	Yes	0	7	7
116	R:R:L186	R:R:V139	8.94	No	Yes	0	4	7
117	R:R:A189	R:R:V139	3.39	No	Yes	0	8	7
118	R:R:G141	R:R:W295	2.81	No	Yes	0	7	8
119	R:R:F146	R:R:L142	10.96	No	No	0	6	7
120	R:R:L142	R:R:S185	7.51	No	Yes	0	7	7
121	R:R:S143	R:R:S185	3.26	No	Yes	0	7	7
122	R:R:A241	R:R:L145	4.73	No	Yes	0	7	8
123	R:R:L145	R:R:L242	2.77	Yes	No	0	8	8
124	R:R:L145	R:R:L291	2.77	Yes	No	0	8	9
125	R:R:L145	R:R:W295	9.11	Yes	Yes	0	8	8
126	R:R:F146	R:R:V181	5.24	No	No	0	6	6
127	R:R:I147	R:R:V181	4.61	No	No	0	7	6
128	R:R:S149	R:R:V244	3.23	No	No	0	6	5
129	R:R:M151	R:R:R155	6.2	Yes	No	7	9	9
130	R:R:M151	R:R:Y346	8.38	Yes	Yes	0	9	9
131	R:R:A152	R:R:T245	3.36	No	Yes	5	9	9
132	R:R:A152	R:R:C248	1.81	No	Yes	5	9	7
133	R:R:A152	R:R:N249	4.69	No	Yes	5	9	9
134	R:R:V153	R:R:V244	1.6	No	No	0	6	5
135	R:R:C248	R:R:V153	3.42	Yes	No	0	7	6
136	R:R:E154	R:R:Y165	6.73	No	No	0	8	8
137	R:R:Q283	R:R:R155	2.34	No	No	0	8	9
138	R:R:A156	R:R:C248	1.81	No	Yes	0	6	7
139	R:R:A156	R:R:T252	1.68	No	No	0	6	9
140	R:R:L157	R:R:W164	2.28	No	No	0	6	4
141	R:R:A158	R:R:Y165	6.67	No	No	0	9	8
142	R:R:A255	R:R:I159	1.62	No	No	0	7	8
143	R:R:I159	R:R:L256	4.28	No	No	0	8	8
144	R:R:A255	R:R:R160	4.15	No	No	0	7	7
145	R:R:A161	R:R:P162	1.87	No	No	0	4	9
146	R:R:A161	R:R:W164	6.48	No	No	0	4	4
147	R:R:H163	R:R:P162	3.05	No	No	0	6	9
148	R:R:H168	R:R:W164	17.98	No	No	0	3	4
149	R:R:M169	R:R:Y165	16.76	No	No	0	5	8
150	R:R:H168	R:R:S167	6.97	No	No	0	3	4
151	R:R:I173	R:R:K170	2.91	No	No	0	5	6
152	R:R:L179	R:R:R175	4.86	No	No	0	3	5
153	R:R:L178	R:R:V177	2.98	Yes	No	0	7	5
154	R:R:G180	R:R:L179	1.71	No	No	0	2	3
155	R:R:G180	R:R:L183	1.71	No	No	0	2	3
156	R:R:S185	R:R:V181	1.62	Yes	No	0	7	6
157	R:R:F188	R:R:L191	3.65	Yes	No	3	8	7
158	R:R:F188	R:R:F230	10.72	Yes	Yes	3	8	6
159	R:R:F188	R:R:F234	5.36	Yes	No	3	8	8
160	R:R:L190	R:R:L194	8.3	No	No	0	6	4
161	R:R:L191	R:R:P192	1.64	No	Yes	3	7	9
162	R:R:F230	R:R:L191	6.09	Yes	No	3	6	7
163	R:R:P192	R:R:Y199	6.95	Yes	Yes	3	9	6
164	R:R:F230	R:R:P192	5.78	Yes	Yes	3	6	9
165	R:R:G195	R:R:L194	1.71	No	No	0	6	4
166	R:R:G226	R:R:V196	1.84	No	No	0	1	4
167	R:R:F230	R:R:V196	2.62	Yes	No	0	6	4
168	R:R:G197	R:R:N227	1.7	No	Yes	0	7	5
169	R:R:F230	R:R:G197	6.02	Yes	No	0	6	7
170	R:R:Q198	R:R:S211	5.78	No	No	9	2	5
171	R:R:N227	R:R:Q198	5.28	Yes	No	9	5	2
172	R:R:I210	R:R:Y199	3.63	No	Yes	0	6	6
173	R:R:S211	R:R:T200	4.8	No	No	0	5	4
174	R:R:G205	R:R:V201	1.84	No	Yes	0	6	5
175	R:R:C208	R:R:V201	1.71	No	Yes	1	9	5
176	R:R:Q202	R:R:W207	15.33	No	Yes	1	8	7
177	R:R:F209	R:R:Q202	7.03	No	No	1	8	8
178	R:R:P204	R:R:W203	5.4	Yes	Yes	1	7	4
179	R:R:C325	R:R:W203	5.22	No	Yes	0	3	4
180	R:R:N326	R:R:W203	6.78	No	Yes	0	1	4
181	R:R:L329	R:R:W203	11.39	No	Yes	1	7	4
182	R:R:P204	R:R:T206	8.74	Yes	Yes	1	7	8
183	R:R:P204	R:R:W207	2.7	Yes	Yes	1	7	7
184	R:R:L329	R:R:P204	4.93	No	Yes	1	7	7
185	R:R:T206	R:R:W207	6.06	Yes	Yes	1	8	7
186	R:R:F209	R:R:W207	8.02	No	Yes	1	8	7
187	R:R:V332	R:R:W207	8.58	No	Yes	0	7	7
188	R:R:F209	R:R:F328	9.65	No	No	0	8	6
189	R:R:F230	R:R:I210	2.51	Yes	No	0	6	6
190	R:R:N227	R:R:S211	4.47	Yes	No	9	5	5
191	R:R:A231	R:R:T212	1.68	No	No	0	6	6
192	R:R:M305	R:R:T212	9.03	No	No	0	6	6
193	R:R:G226	R:R:L228	1.71	No	No	0	1	4
194	R:R:L228	R:R:N227	4.12	No	Yes	0	4	5
195	R:R:A231	R:R:M302	1.61	No	No	0	6	7
196	R:R:A231	R:R:I306	1.62	No	No	0	6	5
197	R:R:I306	R:R:S232	6.19	No	No	0	5	4
198	R:R:A235	R:R:M302	3.22	No	No	0	8	7
199	R:R:G238	R:R:L237	1.71	No	No	0	7	5
200	R:R:G238	R:R:L242	1.71	No	No	0	7	8
201	R:R:L239	R:R:T243	4.42	No	No	0	6	4
202	R:R:L239	R:R:L299	5.54	No	No	0	6	8
203	R:R:C248	R:R:T245	1.69	Yes	Yes	5	7	9
204	R:R:N249	R:R:T245	4.39	Yes	Yes	5	9	9
205	R:R:L291	R:R:T245	2.95	No	Yes	0	9	9
206	R:R:F246	R:R:L250	3.65	No	No	0	5	4
207	R:R:F246	R:R:M288	6.22	No	No	0	5	8
208	R:R:C248	R:R:N249	6.3	Yes	Yes	5	7	9
209	R:R:L284	R:R:N249	12.36	No	Yes	0	9	9
210	R:R:K254	R:R:L250	7.05	No	No	0	3	4
211	R:R:A251	R:R:K254	1.61	No	No	0	5	3
212	R:R:L284	R:R:T252	2.95	No	No	0	9	9
213	R:R:A281	R:R:I253	1.62	No	Yes	0	7	6
214	R:R:I253	R:R:L284	2.85	Yes	No	0	6	9
215	R:R:L256	R:R:T280	4.42	No	Yes	0	8	8
216	R:R:K263	R:R:R259	11.14	No	No	4	4	7
217	R:R:R259	R:R:W273	5	No	No	4	7	4
218	R:R:C260	R:R:G274	1.96	No	No	4	5	5
219	R:R:C260	R:R:T277	8.45	No	Yes	4	5	8
220	R:R:A262	R:R:K263	1.61	No	No	0	5	4
221	R:R:K263	R:R:W273	9.28	No	No	4	4	4
222	R:R:Q272	R:R:R275	2.34	No	No	0	3	6
223	R:R:T277	R:R:W273	2.43	Yes	No	4	8	4
224	R:R:G274	R:R:T277	3.64	No	Yes	4	5	8
225	R:R:E279	R:R:L353	2.65	No	No	0	7	7
226	R:R:A281	R:R:M285	3.22	No	No	0	7	6
227	R:R:G286	R:R:M285	1.75	No	No	0	5	6
228	R:R:I287	R:R:V345	3.07	No	No	0	8	8
229	R:R:I287	R:R:Y346	12.09	No	Yes	0	8	9
230	R:R:M288	R:R:S292	3.07	No	No	0	8	6
231	R:R:L289	R:R:V293	2.98	No	No	0	4	6
232	R:R:V290	R:R:V345	1.6	No	No	0	8	8
233	R:R:L291	R:R:N338	4.12	No	Yes	0	9	9
234	R:R:C294	R:R:W295	7.84	No	Yes	2	8	8
235	R:R:A335	R:R:C294	1.81	No	No	2	8	8
236	R:R:C294	R:R:N338	9.45	No	Yes	2	8	9
237	R:R:A335	R:R:W295	2.59	No	Yes	2	8	8
238	R:R:N338	R:R:W295	6.78	Yes	Yes	2	9	8
239	R:R:P297	R:R:S296	1.78	No	No	0	9	6
240	R:R:L298	R:R:P297	1.64	No	No	0	7	9
241	R:R:A331	R:R:P297	3.74	No	No	0	7	9
242	R:R:F328	R:R:M301	22.39	No	No	0	6	5
243	R:R:K304	R:R:Q322	4.07	No	No	0	3	1
244	R:R:E324	R:R:K304	5.4	No	No	0	3	3
245	R:R:M305	R:R:Q322	10.88	No	No	0	6	1
246	R:R:I330	R:R:L334	2.85	No	No	0	4	6
247	R:R:L334	R:R:L337	5.54	No	No	0	6	4
248	R:R:I340	R:R:L337	5.71	Yes	No	2	9	4
249	R:R:D342	R:R:N338	4.04	Yes	Yes	2	9	9
250	R:R:I340	R:R:L341	5.71	Yes	No	0	9	7
251	R:R:D342	R:R:P343	1.61	Yes	Yes	2	9	9
252	R:R:D342	R:R:Y346	5.75	Yes	Yes	0	9	9
253	R:R:L348	R:R:P343	1.64	No	Yes	0	8	9
254	R:R:L348	R:R:W344	28.47	No	No	0	8	8
255	R:R:L347	R:R:L348	4.15	No	No	0	9	8
256	R:R:L349	R:R:R350	10.93	No	No	0	7	8
257	R:R:I352	R:R:L349	5.71	No	No	0	6	7
258	R:R:L353	R:R:R350	8.5	No	No	0	7	8
259	R:R:K356	R:R:L353	4.23	No	No	0	5	7
260	R:R:L354	R:R:R355	8.5	No	No	0	7	5
261	R:R:A235	R:R:L299	1.58	No	No	0	8	8
262	R:R:T106	R:R:T136	1.57	No	No	0	6	5
263	R:R:T277	R:R:T280	1.57	Yes	Yes	0	8	8
264	R:R:I111	R:R:V112	1.54	No	No	0	7	5
265	R:R:I253	R:R:V257	1.54	Yes	No	0	6	5
266	R:R:I159	R:R:T252	1.52	No	No	0	8	9
267	R:R:I253	R:R:T280	1.52	Yes	Yes	0	6	8
268	R:R:I276	R:R:T280	1.52	No	Yes	0	6	8
269	R:R:L60	R:R:V64	1.49	No	No	0	5	4
270	R:R:L190	R:R:V193	1.49	No	No	0	6	4
271	R:R:L240	R:R:V244	1.49	No	No	0	2	5
272	R:R:I111	R:R:I56	1.47	No	No	0	7	4
273	R:R:L90	R:R:T171	1.47	No	No	0	6	4
274	R:R:D342	R:R:S144	1.47	Yes	No	0	9	8
275	R:R:L178	R:R:T174	1.47	Yes	No	0	7	6
276	R:R:I210	R:R:M137	1.46	No	No	0	6	7
277	R:R:Q272	R:R:S270	1.44	No	No	0	3	4
278	R:R:K304	R:R:M301	1.44	No	No	0	3	5
279	R:R:I253	R:R:L250	1.43	Yes	No	0	6	4
280	R:R:G65	R:R:W344	1.41	No	No	0	9	8
281	R:R:A331	R:R:F328	1.39	No	No	0	7	6
282	R:R:L71	R:R:L72	1.38	No	No	0	4	8
283	R:R:A264	R:R:R261	1.38	No	No	0	3	4
284	R:R:E279	R:R:I276	1.37	No	No	0	7	6
285	R:R:E324	R:R:K323	1.35	No	No	0	3	1
286	R:R:F229	R:R:S232	1.32	No	No	0	4	4
287	R:R:R261	R:R:T265	1.29	No	No	0	4	3
288	R:R:R275	R:R:T278	1.29	No	No	0	6	5
289	R:R:F327	R:R:M301	1.24	No	No	0	3	5
290	R:R:F357	R:R:R275	1.07	No	No	0	3	6
291	R:R:F140	R:R:W182	1	Yes	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F54	5.0125	4	1	4
2	R:R:G62	2.1725	4	2	9
3	R:R:N66	4.995	4	2	9
4	R:R:M70	3.2775	4	2	7
5	R:R:F88	5.75	4	7	8
6	R:R:D99	5.602	5	2	9
7	R:R:Q103	3.556	5	2	8
8	R:R:V113	5.275	4	1	7
9	R:R:W120	6.55143	7	1	5
10	R:R:L135	3.76833	6	3	6
11	R:R:T138	4.2625	4	3	7
12	R:R:V139	5.68	4	0	7
13	R:R:F140	2.64	4	8	8
14	R:R:L145	4.845	4	0	8
15	R:R:M151	6.105	4	7	9
16	R:R:L178	3.4425	4	0	7
17	R:R:S185	4.7125	4	0	7
18	R:R:F188	6.23	4	3	8
19	R:R:P192	4.825	4	3	9
20	R:R:Y199	5.69167	6	3	6
21	R:R:V201	3.8	5	1	5
22	R:R:W203	6.494	5	1	4
23	R:R:P204	5.4425	4	1	7
24	R:R:T206	5.998	5	1	8
25	R:R:W207	7.28333	6	1	7
26	R:R:N227	3.8925	4	9	5
27	R:R:F230	5.62333	6	3	6
28	R:R:T245	3.0975	4	5	9
29	R:R:C248	3.006	5	5	7
30	R:R:N249	6.935	4	5	9
31	R:R:I253	1.792	5	0	6
32	R:R:T277	4.0225	4	4	8
33	R:R:T280	2.2575	4	0	8
34	R:R:W295	5.826	5	2	8
35	R:R:N338	6.0975	4	2	9
36	R:R:I340	5.67333	6	2	9
37	R:R:D342	4.845	6	2	9
38	R:R:P343	2.28833	6	2	9
39	R:R:Y346	7.4625	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q103	R:R:Q339	13.7111	7.68	Yes	No	0	8	8
2	R:R:D99	R:R:Q339	14.8512	15.66	Yes	No	0	9	8
3	R:R:D99	R:R:L95	27.6936	2.71	Yes	No	2	9	9
4	R:R:I147	R:R:L95	87.6265	5.71	No	No	0	7	9
5	R:R:I147	R:R:V181	87.508	4.61	No	No	0	7	6
6	R:R:S185	R:R:V181	86.6295	1.62	Yes	No	0	7	6
7	R:R:S185	R:R:V139	100	6.46	Yes	Yes	0	7	7
8	R:R:F140	R:R:V139	75.6379	3.93	Yes	Yes	0	8	7
9	R:R:F140	R:R:G102	72.9579	3.01	Yes	No	8	8	8
10	R:R:G102	R:R:L105	72.4791	1.71	No	No	0	8	6
11	R:R:L105	R:R:T136	71.6598	4.42	No	No	0	6	5
12	R:R:T106	R:R:T136	70.7764	1.57	No	No	0	6	5
13	R:R:F133	R:R:T106	69.8929	9.08	No	No	0	6	6
14	R:R:F133	R:R:W207	48.275	3.01	No	Yes	0	6	7
15	R:R:G62	R:R:I340	10.3006	3.53	Yes	Yes	2	9	9
16	R:R:G62	R:R:N66	14.0023	1.7	Yes	Yes	2	9	9
17	R:R:D99	R:R:N66	15.7347	4.04	Yes	Yes	2	9	9
18	R:R:L348	R:R:P343	18.701	1.64	No	Yes	0	8	9
19	R:R:D99	R:R:P343	10.6461	1.61	Yes	Yes	2	9	9
20	R:R:D342	R:R:P343	25.5664	1.61	Yes	Yes	2	9	9
21	R:R:D342	R:R:L95	60.1254	12.21	Yes	No	2	9	9
22	R:R:I92	R:R:Y346	10.2019	3.63	No	Yes	0	8	9
23	R:R:D342	R:R:Y346	33.5077	5.75	Yes	Yes	0	9	9
24	R:R:M151	R:R:Y346	20.0286	8.38	Yes	Yes	0	9	9
25	R:R:C91	R:R:M151	17.4374	4.86	No	Yes	0	7	9
26	R:R:C91	R:R:L178	17.4078	4.76	No	Yes	0	7	7
27	R:R:L178	R:R:W94	16.0407	4.56	Yes	No	0	7	8
28	R:R:T98	R:R:W94	15.1523	6.06	No	No	0	9	8
29	R:R:S143	R:R:T98	15.784	1.6	No	No	0	7	9
30	R:R:S143	R:R:S185	16.855	3.26	No	Yes	0	7	7
31	R:R:L178	R:R:T174	14.6587	1.47	Yes	No	0	7	6
32	R:R:F133	R:R:V109	25.137	23.6	No	No	0	6	6
33	R:R:A189	R:R:L135	28.735	3.15	No	Yes	0	8	6
34	R:R:A189	R:R:V139	51.8385	3.39	No	Yes	0	8	7
35	R:R:A189	R:R:T138	22.2348	1.68	No	Yes	0	8	7
36	R:R:L135	R:R:P192	15.4533	4.93	Yes	Yes	3	6	9
37	R:R:F188	R:R:T138	14.9845	5.19	Yes	Yes	3	8	7
38	R:R:D342	R:R:N338	68.4764	4.04	Yes	Yes	2	9	9
39	R:R:L291	R:R:N338	58.0327	4.12	No	Yes	0	9	9
40	R:R:C248	R:R:T245	12.6795	1.69	Yes	Yes	5	7	9
41	R:R:L291	R:R:T245	53.5808	2.95	No	Yes	0	9	9
42	R:R:N249	R:R:T245	38.8085	4.39	Yes	Yes	5	9	9
43	R:R:L284	R:R:N249	38.6407	12.36	No	Yes	0	9	9
44	R:R:I253	R:R:T280	19.8312	1.52	Yes	Yes	0	6	8
45	R:R:I253	R:R:L284	32.2393	2.85	Yes	No	0	6	9
46	R:R:F188	R:R:F230	12.5463	10.72	Yes	Yes	3	8	6
47	R:R:F230	R:R:P192	13.0744	5.78	Yes	Yes	3	6	9
48	R:R:F230	R:R:G197	15.631	6.02	Yes	No	0	6	7
49	R:R:G197	R:R:N227	13.0497	1.7	No	Yes	0	7	5
50	R:R:F209	R:R:W207	31.9135	8.02	No	Yes	1	8	7
51	R:R:F209	R:R:F328	30.8524	9.65	No	No	0	8	6
52	R:R:A231	R:R:T212	13.3656	1.68	No	No	0	6	6
53	R:R:M305	R:R:T212	14.6538	9.03	No	No	0	6	6
54	R:R:M305	R:R:Q322	16.0802	10.88	No	No	0	6	1
55	R:R:K304	R:R:Q322	17.4967	4.07	No	No	0	3	1
56	R:R:K304	R:R:M301	21.682	1.44	No	No	0	3	5
57	R:R:F328	R:R:M301	24.2979	22.39	No	No	0	6	5
58	R:R:T206	R:R:W207	13.8295	6.06	Yes	Yes	1	8	7
59	R:R:D342	R:R:D99	13.7209	3.99	Yes	Yes	2	9	9
60	R:R:V109	R:R:W120	21.6524	3.68	No	Yes	1	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7WU9_nogp

PDB Summary
PDB	7WU9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.6
Number of Linked Nodes	249
Number of Links	291
Number of Hubs	39
Number of Links mediated by Hubs	145
Number of Communities	9
Number of Nodes involved in Communities	69
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	39227
Length Of Smallest Path	3
Average Path Length	14.7193
Length of Longest Path	39
Minimum Path Strength	1.18
Average Path Strength	5.02504
Maximum Path Strength	16.31
Minimum Path Correlation	0.7
Average Path Correlation	0.927833
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	48.3979
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.007
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • intestine smooth muscle contraction • multicellular organismal process • gastro-intestinal system smooth muscle contraction • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • muscle system process • cell death • phospholipase C-activating G protein-coupled receptor signaling pathway • defense response • response to stress • inflammatory response • regulation of localization • transport • digestive system process • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of multicellular organismal process • negative regulation of digestive system process • regulation of gastric acid secretion • regulation of transport • secretion • acid secretion • regulation of digestive system process • establishment of localization • gastric acid secretion • regulation of secretion • digestion • negative regulation of multicellular organismal process • negative regulation of gastric acid secretion • acute-phase response • regulation of defense response • regulation of heat generation • regulation of response to external stimulus • homeostatic process • positive regulation of heat generation • positive regulation of biological process • positive regulation of acute inflammatory response • heat generation • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stress • positive regulation of fever generation • acute inflammatory response • fever generation • response to external stimulus • regulation of inflammatory response • multicellular organismal-level homeostasis • regulation of response to stimulus • positive regulation of defense response • temperature homeostasis • regulation of acute inflammatory response • positive regulation of multicellular organismal process • regulation of fever generation • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular organelle • organelle envelope • intracellular anatomical structure • organelle • nuclear envelope • nucleus • intracellular membrane-bounded organelle • endomembrane system • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43115
Sequence	>7WU9_nogp_Chain_R S V S V A F P I T M L L T G F V G N A L A M L L V S R S Y R R R K R K K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K W E H I D P S G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A P H W Y A S H M K T R I T R A V L L G V W L A S L A F A L L P V L G V G Q Y T V Q W P G T W C F I S T G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V D R C R A K A T S A Q W G R I T T E T A I Q L M G I M L V L S V C W S P L L I M M L K M I F Q K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I L L R K F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GDC	A	Lipid	Prostanoid	EP₃	Homo sapiens	PGE2	-	Gi1/β1/γ2	3.5	2024-01-03	10.1073/pnas.2216329120
	8GDC (No Gprot)	A	Lipid	Prostanoid	EP₃	Homo sapiens	PGE2	-		3.5	2024-01-03	10.1073/pnas.2216329120
	7WU9	A	Lipid	Prostanoid	EP₃	Homo sapiens	-	-	Gi1/β1/γ2	3.38	2022-08-17	10.1016/j.celrep.2022.111323
	7WU9 (No Gprot)	A	Lipid	Prostanoid	EP₃	Homo sapiens	-	-		3.38	2022-08-17	10.1016/j.celrep.2022.111323
	6M9T	A	Lipid	Prostanoid	EP₃	Homo sapiens	Misoprostol-FA	-	-	2.5	2018-12-05	10.1038/s41589-018-0160-y
	6AK3	A	Lipid	Prostanoid	EP₃	Homo sapiens	Dinoprostone IPGE2	-	-	2.9	2018-12-05	10.1038/s41589-018-0171-8
	6AK3 (Multimeric)	A	Lipid	Prostanoid	EP₃	Homo sapiens	Dinoprostone IPGE2	-		2.9	2018-12-05	10.1038/s41589-018-0171-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WU9_nogp.zip

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