Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q31 7.75254104
2A:A:D33 5.18405
3A:A:K34 10.1554104
4A:A:Y37 9.5385104
5A:A:H41 11.2525486
6A:A:F219 7.21167688
7A:A:M221 9.6275488
8A:A:Q227 6.365619
9A:A:R232 10.26418
10A:A:K233 9.70333619
11A:A:W234 11.3225419
12A:A:I245 6.6225467
13A:A:F246 5.3075409
14A:A:D249 8.60754128
15A:A:S251 6.024129
16A:A:F273 7.398336139
17A:A:W277 11.215136
18A:A:W281 9.995615
19A:A:I288 8.328569
20A:A:L289 8.1925139
21A:A:F290 12.3517669
22A:A:N292 7.7409
23A:A:Q294 8.79406
24A:A:L296 5.34254126
25A:A:E309 7.8125404
26A:A:F312 7.521676148
27A:A:D331 10.4654224
28A:A:V334 5.8245224
29A:A:F340 11.72754147
30A:A:F345 10.72254138
31A:A:S349 6.454137
32A:A:R356 10.4575402
33A:A:H362 15.4675469
34A:A:T364 9.8275469
35A:A:D368 10.79469
36A:A:N371 8.286569
37A:A:R374 13.8717664
38A:A:F376 7.41488
39A:A:I383 5.076588
40A:A:H387 5.6375408
41A:A:L388 5.048528
42A:A:Y391 11.352524
43A:A:L394 4.9275428
44B:B:L30 5.7175405
45B:B:H54 12.5925409
46B:B:L55 7.63754106
47B:B:K57 11.78419
48B:B:Y59 11.0775418
49B:B:W63 8.606577
50B:B:V71 5.595408
51B:B:Q75 12.2775419
52B:B:D76 7.4565109
53B:B:L79 5.875407
54B:B:I80 8.72408
55B:B:W82 11.5917679
56B:B:N88 7.5645197
57B:B:K89 7.856509
58B:B:H91 8.0254215
59B:B:I93 7.19407
60B:B:L95 6.3385158
61B:B:W99 12.264509
62B:B:Y105 5.922506
63B:B:Y111 7.132504
64B:B:I120 5.38254156
65B:B:Y124 8.2065156
66B:B:R137 15.42535
67B:B:H142 7.934539
68B:B:Y145 8.37143718
69B:B:C149 4.2425438
70B:B:F151 7.27509
71B:B:L152 7.985403
72B:B:N155 7.7825433
73B:B:I157 6.544537
74B:B:T159 5.586539
75B:B:D163 5.81409
76B:B:L168 6.72754116
77B:B:W169 11.1417638
78B:B:I171 12.7075436
79B:B:T173 6.6425435
80B:B:F180 10.17254117
81B:B:H183 9.038509
82B:B:F199 10.414119
83B:B:K209 10506
84B:B:L210 6.772545
85B:B:W211 11.57254118
86B:B:Q220 7.13447
87B:B:F222 9.176548
88B:B:H225 11.406549
89B:B:I232 6.615448
90B:B:F234 5.238505
91B:B:F235 7.574186
92B:B:F241 9.808546
93B:B:T243 7.90333648
94B:B:R251 7.28714748
95B:B:F253 9.298546
96B:B:L261 5.17405
97B:B:M262 8.12404
98B:B:Y264 9.875405
99B:B:I269 4.09254164
100B:B:F278 9.2754187
101B:B:R283 7.705409
102B:B:L286 7.03557
103B:B:Y289 8.276676167
104B:B:D290 8.7775416
105B:B:C294 5.8325405
106B:B:N295 6.1065166
107B:B:V296 4.926555
108B:B:L308 10.78457
109B:B:R314 18.7518
110B:B:L318 6.645406
111B:B:W332 13.4719
112B:B:D333 10.22459
113B:B:K337 11.77456
114B:B:W339 11.09559
115G:G:R27 2.6625408
116G:G:F61 8.5678
117R:R:H2723 4.885409
118R:R:F2724 9.215409
119R:R:M2728 6.204598
120R:R:F2757 6.675239
121R:R:L2758 5.77409
122R:R:Y2765 6.545408
123R:R:Y2775 16.694525
124R:R:I2779 8.645429
125R:R:L2800 4.4575404
126R:R:L2816 6.7025409
127R:R:H2817 8.763336179
128R:R:Y2818 7.535428
129R:R:W2826 10.09628
130R:R:M2827 5.49409
131R:R:H2833 11.59429
132R:R:F2842 10.64488
133R:R:Y2845 9.6054108
134R:R:Y2849 14.4875428
135R:R:F2853 8.972528
136R:R:W2858 7.74667626
137R:R:Y2876 8.0465178
138R:R:F2885 10.2125407
139R:R:W2887 8.175178
140R:R:I2888 9.3745179
141R:R:F2894 8.23254179
142R:R:F2906 6.7525409
143R:R:V2923 5.6725426
144R:R:F2947 10.775499
145R:R:L2951 8.055408
146R:R:T2952 8.03499
147R:R:W2953 11.25698
148R:R:F2974 5.835495
149R:R:Q2978 8.5625409
150R:R:F2983 6.98754239
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:K34 B:B:L55 28.78457.05YesYes1046
2A:A:K34 A:A:Q31 52.54138.14YesYes1044
3A:A:R38 A:A:Y37 71.35718.23NoYes1044
4A:A:R38 R:R:Y2845 47.60118.23NoYes1048
5A:A:Q35 R:R:Y2845 23.8244.51NoYes1038
6A:A:Q31 R:R:P2847 76.27886.32YesNo1047
7A:A:R42 A:A:Y37 96.593323.66NoYes094
8A:A:R42 B:B:W99 96.50386NoYes099
9R:R:I2846 R:R:P2847 1005.08NoNo077
10R:R:I2846 R:R:Y2849 99.553510.88NoYes078
11R:R:Y2775 R:R:Y2849 43.631727.8YesYes258
12R:R:H2833 R:R:Y2775 14.790916.33YesYes295
13A:A:F238 B:B:W99 21.856920.04NoYes099
14A:A:F238 A:A:L44 21.470820.7NoNo099
15A:A:I244 A:A:L44 11.60518.56NoNo089
16B:B:L117 B:B:W99 27.76114.56NoYes099
17A:A:Q227 B:B:L117 27.35465.32YesNo099
18B:B:W332 B:B:Y59 31.852613.5YesYes198
19B:B:K57 B:B:W332 29.60419.73YesYes199
20B:B:K57 B:B:Q75 29.962417.63YesYes199
21B:B:Q75 B:B:Y59 29.832614.65YesYes198
22B:B:Q75 B:B:W99 60.10297.67YesYes099
23A:A:I244 A:A:V287 11.4764.61NoNo086
24R:R:I2779 R:R:Y2775 29.744314.51YesYes295
25R:R:F2853 R:R:Y2849 55.748413.41YesYes288
26R:R:F2853 R:R:I2779 29.1325.02YesYes289
27R:R:I2779 R:R:W2826 53.19988.22YesYes298
28R:R:L2783 R:R:W2826 56.65364.56NoYes078
29R:R:L2783 R:R:M2827 56.30297.07NoYes079
30R:R:M2827 R:R:Q2978 50.61486.8YesYes099
31R:R:F2947 R:R:Q2978 19.57079.37YesYes099
32R:R:F2853 R:R:L2829 26.470112.18YesNo088
33R:R:L2829 R:R:W2826 26.09489.11NoYes088
34B:B:N313 B:B:W332 57.59676.78NoYes079
35B:B:D312 B:B:N313 57.34785.39NoNo057
36B:B:D312 B:B:D333 57.098813.31NoYes059
37B:B:D333 B:B:H311 27.40738.82YesNo599
38B:B:H311 B:B:K337 27.155113.1NoYes596
39B:B:K337 B:B:W339 26.4046.96YesYes569
40B:B:L308 B:B:W339 25.647525.06YesYes579
41B:B:L308 B:B:V296 50.25174.47YesYes575
42B:B:L284 B:B:V296 49.25835.96NoYes055
43B:B:L284 B:B:S279 48.2389.01NoNo059
44B:B:S279 G:G:D48 47.72784.42NoNo099
45G:G:D48 G:G:L51 46.19679.5NoNo096
46B:B:R283 G:G:L51 44.15447.29YesNo096
47B:B:L300 B:B:R283 40.06674.86NoYes069
48B:B:L30 B:B:L300 37.50984.15YesNo056
49B:B:L30 B:B:M262 26.73517.07YesYes054
50B:B:M262 B:B:S31 10.31014.6YesNo041
51B:B:D333 B:B:S331 28.4324.42YesNo599
52B:B:S331 B:B:V315 28.17984.85NoNo097
53B:B:C294 B:B:V315 27.9275.12YesNo057
54B:B:C294 B:B:L308 25.62757.94YesYes057
55B:B:G162 B:B:Y145 26.716410.14NoYes198
56B:B:G162 B:B:S161 26.61173.71NoNo099
57B:B:D163 B:B:S161 17.56445.89YesNo099
58B:B:D163 B:B:T164 16.63664.34YesNo096
59B:B:H183 B:B:T164 16.10184.11YesNo096
60B:B:H183 B:B:K209 13.381117.03YesYes096
61B:B:K209 G:G:Q18 10.70744.07YesNo069
62G:G:L15 G:G:Q18 10.4345.32NoNo029
63B:B:M262 B:B:Y264 15.438414.37YesYes045
64B:B:W297 B:B:Y264 14.427115.43NoYes085
65R:R:Q2978 R:R:W2953 26.53668.76YesYes098
66R:R:F2724 R:R:W2953 17.77376.01YesYes098
67R:R:F2724 R:R:F2794 13.80687.5YesNo098
68R:R:F2955 R:R:L2970 12.88314.87NoNo089
69R:R:W2826 R:R:W2858 21.37513.12YesYes286
70R:R:V2822 R:R:W2858 18.125112.26NoYes266
71R:R:P2861 R:R:V2822 17.77875.3NoNo096
72R:R:P2861 R:R:T2825 17.41985.25NoNo097
73R:R:T2825 R:R:Y2901 16.70714.99NoNo078
74R:R:L2821 R:R:Y2901 12.4677.03NoNo098
75R:R:H2817 R:R:L2821 10.03165.14YesNo099
76A:A:K34 A:A:R38 23.80889.9YesNo1044
77A:A:Y37 B:B:L55 23.93155.86YesYes1046
78A:A:Q227 B:B:Y145 26.15695.64YesYes198
79A:A:Q31 R:R:Y2845 23.809410.15YesYes1048
80A:A:Q35 R:R:P2847 23.81212.63NoNo1037
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WUJ
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRG4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.3
Date 2022-04-27
D.O.I. doi.org/10.1038/s41586-022-04590-8
Net Summary
Imin 4.41
Number of Linked Nodes 844
Number of Links 999
Number of Hubs 150
Number of Links mediated by Hubs 547
Number of Communities 24
Number of Nodes involved in Communities 210
Number of Links involved in Communities 296
Path Summary
Number Of Nodes in MetaPath 81
Number Of Links MetaPath 80
Number of Shortest Paths 3812651
Length Of Smallest Path 3
Average Path Length 33.0586
Length of Longest Path 58
Minimum Path Strength 1.285
Average Path Strength 8.87905
Maximum Path Strength 26.86
Minimum Path Correlation 0.7
Average Path Correlation 0.99038
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 40.8863
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.6096
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7WUJ_Chain_A
CTLSAEDKA AVERSKMIE KQLQKDKQV YRATHRLLL LGADNSGKS 
TIVKQMRIY HVVKTSGIF ETKFQVDKV NFHMFDVGA QRDERRKWI 
QCFNDVTAI IFVVDSSDY LQEALNDFK SIWNNRWLR TISVILFLN 
KQDLLAEKV LAGKSKIED YFPEFARYT TPEDAGEDP RVTRAKYFI 
RDEFLRIST ASGDGRHYC YPHFTCSVD TENARRIFN DCRDIIQRM 
HLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WUJ_Chain_B
LRQEAEQLK NQIRDARKA CADATLSQI TNNIDPVGR IQMRTRRTL 
RGHLAKIYA MHWGTDSRL LVSASQDGK LIIWDSYTT NKVHAIPLR 
SSWVMTCAY APSGNYVAC GGLDNICSI YNLKTREGN VRVSRELAG 
HTGYLSCCR FLDDNQIVT SSGDTTCAL WDIETGQQT TTFTGHTGD 
VMSLSLAPD TRLFVSGAC DASAKLWDV REGMCRQTF TGHESDINA 
ICFFPNGNA FATGSDDAT CRLFDLRAD QELMTYSHD NIICGITSV 
SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT 
DDGMAVATG SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WUJ_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8IZF6
Sequence
>7WUJ_Chain_R
THFGVLMDL SRSTVSVNE QILALITYT GCGISSIFL GVAVVTYIA 
FHKLRKDYP AKILINLCT ALLMLNLVF LINSWLSSF QKVGVCITA 
AVALHYFLL VSFTWMGLE AVHMYLALV KVFNIYIPN YILKFCLVG 
WGIPAIMVA ITVSVKKDL YGTPFCWIK DDSIFYISV VAYFCLIFL 
MNLSMFCTV LVQLNSVKS RRKMILHDL KGTMSLTFL LGLTWGFAF 
FAWGPMRNF FLYLFAIFN TLQGFFIFV FHCVMKESV REQWQI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
adgrg4_on7WUJ-ADGRG4-chim(NtGi1-Gs)/β1/γ2
adgrg4_on_gp7WUJ-ADGRG4-chim(NtGi1-Gs)/β1/γ2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WUJB2AdhesionAdhesionADGRG4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32022-04-27doi.org/10.1038/s41586-022-04590-8
7WUJ (No Gprot) B2AdhesionAdhesionADGRG4Homo sapiens--3.32022-04-27doi.org/10.1038/s41586-022-04590-8




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WUJ.zip



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