Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 9.5385114
2A:A:H41 11.2525436
3A:A:L46 5.0875448
4A:A:I56 7.5675437
5A:A:M60 8.6475439
6A:A:F212 8.6175439
7A:A:F219 7.21167638
8A:A:M221 9.9875438
9A:A:F222 9.1154217
10A:A:Q227 6.365619
11A:A:R232 9.3675418
12A:A:K233 9.7719
13A:A:F238 12.56754219
14A:A:I245 6.464537
15A:A:F246 6.396549
16A:A:Q267 5.8025404
17A:A:L270 9.51446
18A:A:F273 6.94749
19A:A:I276 5.495448
20A:A:W277 10.165646
21A:A:W281 9.07286715
22A:A:L282 8.07409
23A:A:L289 8.192549
24A:A:F290 11.16539
25A:A:N292 7.3575409
26A:A:Q294 8.5475406
27A:A:F312 7.67648
28A:A:E314 10.0175446
29A:A:D323 8.66754164
30A:A:R333 8.34754235
31A:A:Y339 9.0025163
32A:A:F340 9.908547
33A:A:R342 6.05754164
34A:A:E344 10.984545
35A:A:F345 10.444548
36A:A:S349 6.45447
37A:A:Y360 13.62588
38A:A:N371 8.32539
39A:A:F376 6.31538
40A:A:I383 5.076538
41A:A:R385 10.8025485
42A:A:H387 5.6375408
43A:A:L388 5.048588
44A:A:Y391 11.352584
45B:B:R19 9.545404
46B:B:V40 4.965403
47B:B:H54 10.92529
48B:B:L55 7.63754116
49B:B:W63 8.606527
50B:B:L70 7.915425
51B:B:V71 5.595408
52B:B:Q75 11.1525409
53B:B:D76 7.4565119
54B:B:L79 5.875407
55B:B:I80 7.848528
56B:B:W82 10.54729
57B:B:N88 7.564527
58B:B:K89 7.27333629
59B:B:H91 8.0254195
60B:B:I93 7.19407
61B:B:L95 6.3385268
62B:B:W99 12.2645219
63B:B:Y105 5.922506
64B:B:Y111 7.4775404
65B:B:Y124 8.2065266
66B:B:E130 4.1075403
67B:B:L139 8.6925409
68B:B:H142 7.9345139
69B:B:Y145 7.05714718
70B:B:C149 4.24254138
71B:B:F151 7.27509
72B:B:L152 7.985403
73B:B:I157 6.92754137
74B:B:T159 5.5865139
75B:B:L168 6.7275466
76B:B:W169 9.165138
77B:B:F180 8.976567
78B:B:H183 8.79167669
79B:B:D186 12.72419
80B:B:F199 9.166569
81B:B:D205 7.4575469
82B:B:K209 9.86667666
83B:B:L210 6.286555
84B:B:W211 11.5725468
85B:B:R219 7.125405
86B:B:Q220 7.478557
87B:B:F222 10.575458
88B:B:H225 10.586559
89B:B:I232 6.995458
90B:B:F234 5.238505
91B:B:F235 6.8885106
92B:B:P236 5.30754107
93B:B:F241 8.85167656
94B:B:T243 7.688558
95B:B:D246 9.8575419
96B:B:T249 5.595456
97B:B:R251 8.11857758
98B:B:F253 9.272556
99B:B:Q259 6.335406
100B:B:L261 5.85405
101B:B:Y264 8.6775405
102B:B:I269 4.09254124
103B:B:F278 9.2754107
104B:B:K280 8.024281
105B:B:R283 7.094509
106B:B:L286 6.7325177
107B:B:Y289 8.276676127
108B:B:D290 8.095416
109B:B:C294 5.8325405
110B:B:N295 5.891676126
111B:B:V296 4.645405
112B:B:D298 8.084249
113B:B:L300 6.26406
114B:B:V307 4.68754123
115B:B:L308 10.78407
116B:B:H311 10.69254149
117B:B:R314 18.938518
118B:B:L318 6.645406
119B:B:W332 13.0067619
120B:B:D333 10.224149
121B:B:L336 5.3775427
122B:B:K337 11.774146
123B:B:W339 11.095149
124R:R:H2723 4.7325299
125R:R:F2724 9.215409
126R:R:L2727 6.8125499
127R:R:M2728 6.204578
128R:R:F2757 6.418579
129R:R:L2758 5.77409
130R:R:Y2765 6.545408
131R:R:F2794 6.9075498
132R:R:L2800 4.4575404
133R:R:L2816 6.192599
134R:R:H2817 8.76333699
135R:R:Y2818 7.5354158
136R:R:W2826 10.096158
137R:R:M2827 5.49409
138R:R:F2842 8.50667638
139R:R:F2853 8.635408
140R:R:W2858 7.746676156
141R:R:Y2876 8.046598
142R:R:F2885 9.158507
143R:R:W2887 8.96498
144R:R:I2888 9.8775499
145R:R:I2893 5.4475403
146R:R:F2894 8.2325499
147R:R:F2902 11.6425409
148R:R:F2906 6.7525409
149R:R:V2923 5.3486
150R:R:F2947 10.775479
151R:R:L2949 5.5625409
152R:R:L2951 7.274508
153R:R:T2952 8.03479
154R:R:W2953 11.25678
155R:R:F2974 5.526575
156R:R:Q2978 8.5625409
157R:R:F2980 6.78479
158R:R:F2981 9.4025474
159R:R:F2983 6.9875479
160R:R:H2986 8.1325406
161R:R:K2990 5.2775409
162G:G:Q18 8.6775469
163G:G:R27 9.302558
164G:G:L51 5.7665256
165G:G:F61 7.90429728
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:S23 B:B:K89 10.07096.12NoYes079
2A:A:I26 B:B:K89 27.26917.27NoYes099
3A:A:I26 A:A:R22 26.67715.01NoNo095
4A:A:R22 B:B:H91 26.09019.03NoYes055
5B:B:I80 B:B:K89 20.33364.36YesYes289
6A:A:L30 B:B:I80 12.04814.28NoYes058
7A:A:L30 B:B:K78 12.26894.23NoNo058
8B:B:D76 B:B:L55 11.04712.21YesYes1196
9B:B:H54 B:B:S74 23.798216.74YesNo099
10B:B:D76 B:B:S74 23.994210.31YesNo099
11B:B:K89 B:B:W82 18.29911.6YesYes299
12B:B:H54 B:B:W82 13.98514.23YesYes299
13A:A:K34 B:B:L55 14.3667.05NoYes1146
14A:A:Y37 B:B:D76 22.65544.6YesYes1149
15A:A:R38 A:A:Y37 85.94198.23NoYes1144
16A:A:K34 R:R:Y2845 14.302115.53NoNo1148
17A:A:R38 R:R:Y2845 85.78388.23NoNo1148
18A:A:Q35 R:R:Y2845 1004.51NoNo038
19A:A:Q35 R:R:P2847 99.915212.63NoNo037
20A:A:R42 A:A:Y37 87.108623.66NoYes094
21A:A:R42 B:B:W99 87.11456NoYes099
22B:B:H91 B:B:V133 16.15065.54YesNo054
23B:B:I93 B:B:V133 15.5926.14YesNo074
24B:B:I93 B:B:Y124 11.122812.09YesYes076
25B:B:S122 B:B:Y124 10.20876.36NoYes086
26B:B:I120 B:B:S122 11.04414.64NoNo068
27B:B:D118 B:B:I120 11.34549.8NoNo096
28A:A:S205 B:B:D118 11.50155.89NoNo079
29A:A:F208 A:A:S205 11.66216.61NoNo057
30A:A:D223 A:A:F208 11.98568.36NoNo095
31A:A:D223 A:A:V57 12.148510.22NoNo097
32A:A:L45 A:A:V57 12.80674.47NoNo087
33A:A:F212 A:A:F219 21.602111.79YesYes398
34A:A:F219 A:A:H41 14.68586.79YesYes386
35A:A:H41 A:A:I383 15.28165.3YesYes368
36A:A:F219 R:R:F2842 14.7415.36YesYes388
37A:A:I383 R:R:F2842 17.48788.79YesYes388
38R:R:I2846 R:R:P2847 99.83315.08NoNo077
39R:R:I2846 R:R:Y2849 99.344210.88NoNo078
40R:R:F2853 R:R:Y2849 99.184213.41YesNo088
41R:R:F2853 R:R:I2779 64.50625.02YesNo089
42R:R:E2830 R:R:I2779 36.99676.83NoNo089
43A:A:Y391 R:R:E2830 33.54057.86YesNo048
44A:A:Y391 R:R:P2776 18.083916.69YesNo849
45A:A:Q390 R:R:P2776 17.93611.05NoNo049
46A:A:H387 A:A:Q390 17.64977.42YesNo084
47A:A:H387 A:A:I383 34.62735.3YesYes088
48A:A:Y391 R:R:H2833 17.906811.98YesNo849
49R:R:A2837 R:R:H2833 17.75865.85NoNo089
50A:A:H387 R:R:A2837 17.61555.85YesNo088
51A:A:F238 B:B:W99 33.53520.04YesYes2199
52A:A:F238 A:A:L44 33.348820.7YesNo099
53A:A:L44 A:A:L46 16.54196.92NoYes098
54A:A:I244 A:A:L44 16.72848.56NoNo089
55B:B:L70 B:B:W82 13.60349.11YesYes259
56B:B:L70 B:B:W63 15.980913.67YesYes257
57B:B:M61 B:B:W63 16.45774.65NoYes067
58B:B:C317 B:B:M61 16.48568.1NoNo076
59B:B:C317 B:B:S316 16.68175.16NoNo079
60B:B:S316 B:B:W332 16.88084.94NoYes099
61A:A:W281 B:B:W332 28.56084.69YesYes159
62A:A:N279 A:A:W281 22.10644.52NoYes085
63A:A:L282 A:A:N279 22.047913.73YesNo098
64A:A:F246 A:A:L46 15.97434.87YesYes498
65A:A:I276 A:A:L282 10.76764.28YesYes089
66A:A:I56 A:A:M60 11.27235.83YesYes379
67B:B:L117 B:B:W99 33.59074.56NoYes099
68A:A:Q227 B:B:L117 33.17345.32YesNo099
69A:A:Q227 B:B:Y145 32.76215.64YesYes198
70A:A:Q236 A:A:W281 26.93410.95NoYes185
71A:A:K233 A:A:Q236 43.29139.49YesNo198
72B:B:R314 B:B:W332 28.411733.99YesYes189
73A:A:Q236 B:B:R314 16.525412.85NoYes188
74B:B:R314 B:B:T274 11.66127.76YesNo188
75B:B:N230 B:B:T274 11.64438.77NoNo198
76A:A:K233 B:B:D246 49.63968.3YesYes199
77B:B:D246 B:B:N230 11.528.08YesNo199
78B:B:Q75 B:B:W99 28.5437.67YesYes099
79B:B:K57 B:B:W332 28.194919.73NoYes099
80A:A:I244 A:A:V287 27.30654.61NoNo086
81A:A:F246 A:A:F273 25.77568.57YesYes499
82A:A:F273 A:A:V287 25.69227.87YesNo496
83A:A:F273 A:A:L289 25.06454.87YesYes499
84A:A:L289 A:A:L291 13.46096.92YesNo098
85A:A:F273 A:A:F345 24.704211.79YesYes498
86A:A:I341 A:A:L291 13.10454.28NoNo088
87A:A:I341 A:A:S250 25.55684.64NoNo086
88A:A:Q294 A:A:S250 15.34024.33YesNo066
89A:A:E344 A:A:F345 21.81369.33YesYes458
90A:A:E344 A:A:I341 13.18510.93YesNo058
91A:A:L289 A:A:P361 11.28818.21YesNo095
92A:A:P361 A:A:R342 10.92515.76NoYes054
93A:A:K338 A:A:Q294 13.157716.27NoYes056
94A:A:K338 A:A:V334 20.09317.59NoNo054
95A:A:L302 A:A:V334 16.44154.47NoNo024
96A:A:L302 A:A:R333 10.96156.07NoYes2325
97A:A:Y391 R:R:M2834 15.198214.37YesNo048
98B:B:D246 B:B:S227 61.03114.42YesNo096
99B:B:D247 B:B:S227 60.79214.42NoNo096
100B:B:D247 B:B:E226 30.015419.49NoNo593
101B:B:E226 B:B:R251 29.765111.63NoYes538
102B:B:F253 B:B:R251 52.29867.48YesYes568
103B:B:F222 B:B:F253 42.426613.93YesYes586
104B:B:F222 B:B:Q220 37.275111.71YesYes587
105B:B:D258 B:B:Q220 22.11386.53NoYes577
106B:B:D258 G:G:R27 13.691721.44NoYes578
107B:B:R22 G:G:R27 25.35492.13NoYes068
108B:B:R19 B:B:R22 13.747312.79YesNo046
109B:B:D247 B:B:T249 30.53745.78NoYes596
110B:B:R251 B:B:T249 29.78647.76YesYes586
111B:B:Q220 G:G:I25 14.2165.49YesNo072
112G:G:I25 G:G:R27 13.74116.26NoYes028
113B:B:Q259 B:B:R22 10.57763.5YesNo066
114B:B:N313 B:B:W332 78.29866.78NoYes079
115B:B:D312 B:B:N313 78.12544.04NoNo057
116B:B:D312 B:B:D333 77.431313.31NoYes059
117B:B:D333 B:B:H311 57.4738.82YesYes1499
118B:B:H311 B:B:T329 38.05744.11YesNo098
119B:B:L318 B:B:T329 19.25194.42YesNo068
120B:B:L286 B:B:L318 18.84978.3YesYes076
121B:B:L286 B:B:V296 17.83944.47YesYes075
122B:B:L284 B:B:V296 69.60225.96NoYes055
123B:B:L284 B:B:S279 67.94029.01NoNo059
124B:B:S279 G:G:D48 67.10894.42NoNo099
125G:G:D48 G:G:L51 65.43849.5NoYes2596
126B:B:R283 G:G:L51 56.24597.29YesYes096
127B:B:L300 B:B:R283 48.7574.86YesYes069
128B:B:L30 B:B:L300 41.23254.15NoYes056
129B:B:L261 B:B:L30 39.55836.92YesNo055
130B:B:L252 B:B:L261 25.29775.54NoYes075
131B:B:L252 B:B:Y264 24.45717.03NoYes075
132B:B:T329 B:B:W339 18.62128.49NoYes089
133B:B:L308 B:B:W339 36.45825.06YesYes079
134B:B:L308 B:B:V296 53.43144.47YesYes075
135B:B:H311 B:B:K337 19.238513.1YesYes1496
136B:B:K337 B:B:W339 18.65446.96YesYes1469
137B:B:D333 B:B:S331 19.01844.42YesNo1499
138B:B:S331 B:B:V315 18.81914.85NoNo097
139B:B:C294 B:B:V315 18.61885.12YesNo057
140B:B:C294 B:B:L308 18.21647.94YesYes057
141B:B:G162 B:B:Y145 28.709310.14NoYes198
142B:B:G162 B:B:S161 28.52083.71NoNo099
143B:B:H142 B:B:S161 26.567615.34YesNo099
144B:B:H142 B:B:T159 22.30155.48YesYes1399
145B:B:C149 B:B:T159 17.1555.07YesYes1389
146B:B:C149 B:B:T102 16.78283.38YesNo088
147B:B:C148 B:B:T102 16.27823.38NoNo068
148B:B:C148 B:B:R150 16.02566.96NoNo066
149B:B:L192 B:B:R150 15.51983.64NoNo056
150B:B:L192 B:B:V158 12.68924.47NoNo055
151B:B:L261 G:G:L37 10.13924.15YesNo057
152B:B:W297 B:B:Y264 18.568115.43NoYes085
153R:R:I2779 R:R:W2826 40.9438.22NoYes098
154R:R:L2783 R:R:W2826 56.32214.56NoYes078
155R:R:L2783 R:R:M2827 55.99067.07NoYes079
156R:R:M2827 R:R:Q2978 50.51996.8YesYes099
157R:R:Q2978 R:R:W2953 28.58668.76YesYes098
158R:R:F2724 R:R:W2953 26.95146.01YesYes098
159R:R:F2724 R:R:F2794 21.53887.5YesYes098
160R:R:F2794 R:R:F2885 15.7494.29YesYes087
161R:R:F2853 R:R:L2829 34.730912.18YesNo088
162R:R:L2829 R:R:W2826 34.33079.11NoYes088
163R:R:F2947 R:R:Q2978 18.96739.37YesYes099
164R:R:L2949 R:R:M2834 14.16017.07YesNo098
165R:R:F2902 R:R:F2906 11.47368.57YesYes099
166R:R:W2826 R:R:W2858 17.948613.12YesYes1586
167R:R:V2822 R:R:W2858 14.699912.26NoYes1566
168R:R:P2861 R:R:V2822 14.36975.3NoNo096
169R:R:P2861 R:R:T2825 14.02265.25NoNo097
170R:R:T2825 R:R:Y2901 13.34214.99NoNo078
171A:A:K233 B:B:Y145 33.00854.78YesYes198
172B:B:K57 B:B:Q75 28.151917.63NoYes099
173A:A:I244 A:A:L282 11.15534.28NoYes089
174A:A:F212 A:A:M60 12.28888.71YesYes399
175A:A:F246 A:A:I276 10.38695.02YesYes498
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WUJ
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRG4
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.3
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04590-8
Net Summary
Imin 4.08
Number of Linked Nodes 845
Number of Links 1037
Number of Hubs 165
Number of Links mediated by Hubs 603
Number of Communities 31
Number of Nodes involved in Communities 243
Number of Links involved in Communities 340
Path Summary
Number Of Nodes in MetaPath 176
Number Of Links MetaPath 175
Number of Shortest Paths 2412336
Length Of Smallest Path 3
Average Path Length 29.1764
Length of Longest Path 54
Minimum Path Strength 1.30333
Average Path Strength 8.30073
Maximum Path Strength 26.86
Minimum Path Correlation 0.7
Average Path Correlation 0.98763
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 46.9251
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.7022
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7WUJ_Chain_A
CTLSAEDKA AVERSKMIE KQLQKDKQV YRATHRLLL LGADNSGKS 
TIVKQMRIY HVVKTSGIF ETKFQVDKV NFHMFDVGA QRDERRKWI 
QCFNDVTAI IFVVDSSDY LQEALNDFK SIWNNRWLR TISVILFLN 
KQDLLAEKV LAGKSKIED YFPEFARYT TPEDAGEDP RVTRAKYFI 
RDEFLRIST ASGDGRHYC YPHFTCSVD TENARRIFN DCRDIIQRM 
HLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WUJ_Chain_B
LRQEAEQLK NQIRDARKA CADATLSQI TNNIDPVGR IQMRTRRTL 
RGHLAKIYA MHWGTDSRL LVSASQDGK LIIWDSYTT NKVHAIPLR 
SSWVMTCAY APSGNYVAC GGLDNICSI YNLKTREGN VRVSRELAG 
HTGYLSCCR FLDDNQIVT SSGDTTCAL WDIETGQQT TTFTGHTGD 
VMSLSLAPD TRLFVSGAC DASAKLWDV REGMCRQTF TGHESDINA 
ICFFPNGNA FATGSDDAT CRLFDLRAD QELMTYSHD NIICGITSV 
SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT 
DDGMAVATG SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8IZF6
Sequence
>7WUJ_Chain_R
THFGVLMDL SRSTVSVNE QILALITYT GCGISSIFL GVAVVTYIA 
FHKLRKDYP AKILINLCT ALLMLNLVF LINSWLSSF QKVGVCITA 
AVALHYFLL VSFTWMGLE AVHMYLALV KVFNIYIPN YILKFCLVG 
WGIPAIMVA ITVSVKKDL YGTPFCWIK DDSIFYISV VAYFCLIFL 
MNLSMFCTV LVQLNSVKS RRKMILHDL KGTMSLTFL LGLTWGFAF 
FAWGPMRNF FLYLFAIFN TLQGFFIFV FHCVMKESV REQWQI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WUJ_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WUJB2AdhesionAdhesionADGRG4Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.32022-04-2710.1038/s41586-022-04590-8




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WUJ.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.