psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E2740	R:R:T2722	8.47	No	No	0	9	9
2	R:R:F2885	R:R:T2722	14.27	Yes	No	0	7	9
3	R:R:D2729	R:R:H2723	6.3	No	Yes	0	9	9
4	R:R:E2740	R:R:H2723	4.92	No	Yes	0	9	9
5	R:R:H2723	R:R:L2743	5.14	Yes	No	0	9	8
6	R:R:F2724	R:R:T2747	6.49	Yes	No	0	9	9
7	R:R:F2724	R:R:F2794	7.5	Yes	No	0	9	8
8	R:R:F2724	R:R:W2953	6.01	Yes	Yes	0	9	8
9	R:R:F2724	R:R:T2976	16.86	Yes	No	0	9	7
10	R:R:F2885	R:R:V2726	13.11	Yes	No	0	7	9
11	R:R:F2794	R:R:L2727	7.31	No	No	0	8	9
12	R:R:L2727	R:R:L2820	5.54	No	No	0	9	8
13	R:R:L2727	R:R:W2887	10.25	No	Yes	0	9	8
14	R:R:F2902	R:R:M2728	11.2	No	Yes	0	9	8
15	R:R:M2728	R:R:W2953	5.82	Yes	Yes	1	8	8
16	R:R:F2971	R:R:M2728	6.22	No	Yes	1	9	8
17	R:R:L2730	R:R:V2899	10.43	No	No	0	8	9
18	R:R:F2894	R:R:R2732	11.76	Yes	No	0	9	9
19	R:R:N2739	R:R:V2735	5.91	No	No	0	9	8
20	R:R:E2740	R:R:S2737	11.5	No	No	0	9	4
21	R:R:N2739	R:R:Y2969	11.63	No	No	0	9	8
22	R:R:L2743	R:R:Y2969	7.03	No	No	0	8	8
23	R:R:S2798	R:R:Y2748	6.36	No	No	0	8	7
24	R:R:C2751	R:R:N2791	7.87	No	No	0	8	9
25	R:R:F2757	R:R:I2753	6.28	Yes	No	0	9	9
26	R:R:N2791	R:R:S2754	5.96	No	No	0	9	9
27	R:R:L2792	R:R:S2755	6.01	No	No	0	6	9
28	R:R:F2757	R:R:I2756	7.54	Yes	No	0	9	8
29	R:R:F2757	R:R:F2980	6.43	Yes	No	0	9	9
30	R:R:F2757	R:R:F2983	11.79	Yes	Yes	5	9	9
31	R:R:C2784	R:R:L2758	9.52	No	Yes	0	8	9
32	R:R:G2979	R:R:L2758	5.13	No	Yes	0	9	9
33	R:R:G2759	R:R:L2788	5.13	No	No	0	9	9
34	R:R:F2768	R:R:T2764	5.19	No	No	0	8	9
35	R:R:T2764	R:R:W2997	10.92	No	No	0	9	8
36	R:R:L2780	R:R:Y2765	7.03	No	Yes	0	8	8
37	R:R:I2781	R:R:Y2765	6.04	No	Yes	0	8	8
38	R:R:C2987	R:R:Y2765	8.06	No	Yes	0	8	8
39	R:R:V2993	R:R:Y2765	5.05	No	Yes	0	8	8
40	R:R:F2768	R:R:L2771	6.09	No	No	6	8	7
41	R:R:F2768	R:R:Q2996	10.54	No	No	6	8	9
42	R:R:L2771	R:R:V2993	5.96	No	No	0	7	8
43	R:R:L2771	R:R:Q2996	7.99	No	No	6	7	9
44	R:R:K2778	R:R:R2772	21.04	No	No	0	9	8
45	R:R:D2774	R:R:K2773	6.91	No	No	0	9	8
46	R:R:I2779	R:R:Y2775	14.51	Yes	Yes	3	9	5
47	R:R:H2833	R:R:Y2775	16.33	No	Yes	0	9	5
48	R:R:Y2775	R:R:Y2849	27.8	Yes	Yes	3	5	8
49	R:R:I2850	R:R:Y2775	14.51	No	Yes	0	8	5
50	R:R:F2853	R:R:Y2775	10.32	Yes	Yes	3	8	5
51	R:R:H2833	R:R:P2776	12.2	No	No	0	9	9
52	R:R:I2850	R:R:K2778	26.17	No	No	0	8	9
53	R:R:I2779	R:R:W2826	8.22	Yes	Yes	0	9	8
54	R:R:E2830	R:R:I2779	6.83	No	Yes	0	8	9
55	R:R:F2853	R:R:I2779	5.02	Yes	Yes	3	8	9
56	R:R:H2986	R:R:L2780	5.14	No	No	0	6	8
57	R:R:N2782	R:R:W2826	20.34	No	Yes	0	9	8
58	R:R:L2783	R:R:M2827	7.07	No	Yes	0	7	9
59	R:R:A2786	R:R:W2826	5.19	No	Yes	0	9	8
60	R:R:L2787	R:R:Q2978	9.32	No	Yes	0	9	9
61	R:R:F2819	R:R:M2789	14.93	No	No	0	8	9
62	R:R:L2790	R:R:L2820	5.54	No	No	0	8	8
63	R:R:L2816	R:R:V2793	5.96	Yes	No	0	9	5
64	R:R:F2794	R:R:L2816	8.53	No	Yes	0	8	9
65	R:R:L2816	R:R:N2797	5.49	Yes	No	0	9	8
66	R:R:F2885	R:R:N2797	8.46	Yes	No	0	7	8
67	R:R:S2798	R:R:W2799	4.94	No	No	0	8	5
68	R:R:L2800	R:R:V2808	7.45	Yes	No	0	4	6
69	R:R:F2803	R:R:V2808	6.55	No	No	0	6	6
70	R:R:C2809	R:R:C2886	7.28	No	No	4	8	8
71	R:R:L2816	R:R:W2887	6.83	Yes	Yes	0	9	8
72	R:R:H2817	R:R:L2821	5.14	Yes	No	0	9	9
73	R:R:H2817	R:R:V2865	9.69	Yes	No	0	9	9
74	R:R:H2817	R:R:T2868	9.58	Yes	No	2	9	6
75	R:R:H2817	R:R:Y2876	11.98	Yes	Yes	2	9	8
76	R:R:H2817	R:R:I2888	10.61	Yes	Yes	2	9	9
77	R:R:H2817	R:R:S2897	5.58	Yes	No	0	9	9
78	R:R:F2819	R:R:Y2818	8.25	No	Yes	0	8	8
79	R:R:V2822	R:R:Y2818	8.83	No	Yes	7	6	8
80	R:R:W2858	R:R:Y2818	7.72	Yes	Yes	7	6	8
81	R:R:A2862	R:R:Y2818	5.34	No	Yes	0	8	8
82	R:R:F2824	R:R:L2820	12.18	No	No	0	7	8
83	R:R:L2821	R:R:Y2901	7.03	No	No	0	9	8
84	R:R:V2822	R:R:W2858	12.26	No	Yes	7	6	6
85	R:R:P2861	R:R:V2822	5.3	No	No	0	9	6
86	R:R:F2824	R:R:F2902	22.51	No	No	0	7	9
87	R:R:F2824	R:R:W2953	16.04	No	Yes	0	7	8
88	R:R:G2857	R:R:T2825	5.46	No	No	0	7	7
89	R:R:P2861	R:R:T2825	5.25	No	No	0	9	7
90	R:R:T2825	R:R:Y2901	4.99	No	No	0	7	8
91	R:R:L2829	R:R:W2826	9.11	No	Yes	0	8	8
92	R:R:W2826	R:R:W2858	13.12	Yes	Yes	0	8	6
93	R:R:M2827	R:R:Q2978	6.8	Yes	Yes	0	9	9
94	R:R:F2853	R:R:L2829	12.18	Yes	No	0	8	8
95	R:R:L2829	R:R:V2856	7.45	No	No	0	8	6
96	R:R:E2830	R:R:L2948	14.58	No	No	0	8	9
97	R:R:A2837	R:R:H2833	5.85	No	No	0	8	9
98	R:R:L2949	R:R:M2834	7.07	No	No	0	9	8
99	R:R:V2839	R:R:Y2835	7.57	No	No	0	9	8
100	R:R:K2840	R:R:Y2835	5.97	No	No	0	6	8
101	R:R:M2912	R:R:Y2835	8.38	No	No	0	8	8
102	R:R:L2836	R:R:Y2849	5.86	No	Yes	0	5	8
103	R:R:T2915	R:R:V2839	6.35	No	No	0	6	9
104	R:R:I2846	R:R:P2847	5.08	No	No	0	7	7
105	R:R:I2846	R:R:Y2849	10.88	No	Yes	0	7	8
106	R:R:F2853	R:R:Y2849	13.41	Yes	Yes	3	8	8
107	R:R:C2854	R:R:W2858	5.22	No	Yes	0	8	6
108	R:R:I2860	R:R:V2856	6.14	No	No	0	6	6
109	R:R:T2868	R:R:Y2876	8.74	No	Yes	2	6	8
110	R:R:D2874	R:R:D2890	5.32	No	No	0	9	9
111	R:R:I2888	R:R:Y2876	10.88	Yes	Yes	2	9	8
112	R:R:F2885	R:R:W2887	5.01	Yes	Yes	0	7	8
113	R:R:I2888	R:R:W2887	11.74	Yes	Yes	2	9	8
114	R:R:F2894	R:R:W2887	7.02	Yes	Yes	2	9	8
115	R:R:I2888	R:R:I2893	7.36	Yes	No	0	9	3
116	R:R:F2894	R:R:I2888	6.28	Yes	Yes	2	9	9
117	R:R:D2890	R:R:I2893	18.19	No	No	0	9	3
118	R:R:D2891	R:R:S2892	5.89	No	No	0	9	6
119	R:R:F2894	R:R:V2898	7.87	Yes	No	0	9	9
120	R:R:V2899	R:R:Y2895	5.05	No	No	0	9	8
121	R:R:I2905	R:R:Y2901	10.88	No	No	0	7	8
122	R:R:F2902	R:R:F2906	8.57	No	No	0	9	9
123	R:R:F2906	R:R:N2909	6.04	No	No	0	9	9
124	R:R:F2906	R:R:G2954	7.53	No	No	0	9	9
125	R:R:L2949	R:R:N2909	5.49	No	No	0	9	9
126	R:R:F2913	R:R:T2942	6.49	No	No	0	9	7
127	R:R:F2913	R:R:L2945	10.96	No	No	0	9	9
128	R:R:F2913	R:R:L2951	15.83	No	No	0	9	8
129	R:R:L2917	R:R:T2942	7.37	No	No	0	6	7
130	R:R:K2924	R:R:M2934	5.76	No	No	0	8	7
131	R:R:G2941	R:R:K2940	5.23	No	Yes	0	8	9
132	R:R:F2985	R:R:M2943	11.2	No	No	0	9	4
133	R:R:L2945	R:R:L2949	5.54	No	No	0	9	9
134	R:R:L2951	R:R:T2946	7.37	No	No	0	8	8
135	R:R:F2947	R:R:T2952	9.08	Yes	Yes	1	9	9
136	R:R:F2947	R:R:F2974	5.36	Yes	Yes	1	9	5
137	R:R:F2947	R:R:Q2978	9.37	Yes	Yes	0	9	9
138	R:R:F2947	R:R:F2981	19.29	Yes	No	0	9	4
139	R:R:H2986	R:R:L2948	19.28	No	No	0	6	9
140	R:R:F2955	R:R:T2952	6.49	No	Yes	1	8	9
141	R:R:F2974	R:R:T2952	7.78	Yes	Yes	1	5	9
142	R:R:N2975	R:R:T2952	8.77	No	Yes	1	9	9
143	R:R:F2971	R:R:W2953	6.01	No	Yes	1	9	8
144	R:R:N2975	R:R:W2953	24.86	No	Yes	1	9	8
145	R:R:Q2978	R:R:W2953	8.76	Yes	Yes	0	9	8
146	R:R:F2955	R:R:F2974	6.43	No	Yes	1	8	5
147	R:R:F2958	R:R:F2967	10.72	No	No	0	9	8
148	R:R:F2967	R:R:R2964	6.41	No	No	0	8	8
149	R:R:F2966	R:R:Y2969	7.22	No	No	0	3	8
150	R:R:F2966	R:R:L2970	8.53	No	No	0	3	9
151	R:R:F2971	R:R:N2975	15.71	No	No	1	9	9
152	R:R:F2980	R:R:L2977	8.53	No	No	0	9	7
153	R:R:F2981	R:R:L2977	9.74	No	No	0	4	7
154	R:R:F2980	R:R:V2984	7.87	No	No	0	9	8
155	R:R:C2987	R:R:F2983	6.98	No	Yes	0	8	9
156	R:R:F2983	R:R:V2988	7.87	Yes	No	0	9	5
157	R:R:F2985	R:R:V2984	7.87	No	No	0	9	8
158	R:R:F2985	R:R:M2989	6.22	No	No	0	9	9
159	R:R:K2990	R:R:S2992	6.12	No	No	0	9	6
160	R:R:E2991	R:R:R2994	6.98	No	No	0	6	8
161	R:R:F2957	R:R:L2730	4.87	No	No	0	8	8
162	R:R:S2870	R:R:V2871	4.85	No	No	0	6	8
163	R:R:I2810	R:R:Y2876	4.84	No	Yes	0	5	8
164	R:R:V2760	R:R:V2763	4.81	No	No	0	6	7
165	R:R:V2814	R:R:V2865	4.81	No	No	0	7	9
166	R:R:S2737	R:R:T2734	4.8	No	No	0	4	7
167	R:R:C2751	R:R:L2795	4.76	No	No	0	8	8
168	R:R:T2785	R:R:V2762	4.76	No	No	0	7	4
169	R:R:M2827	R:R:S2823	4.6	Yes	No	0	9	9
170	R:R:K2940	R:R:S2944	4.59	Yes	No	0	9	9
171	R:R:M2728	R:R:V2899	4.56	Yes	No	0	8	9
172	R:R:M2834	R:R:V2916	4.56	No	No	0	8	9
173	R:R:K2805	R:R:V2808	4.55	No	No	0	4	6
174	R:R:N2791	R:R:S2755	4.47	No	No	0	9	9
175	R:R:I2766	R:R:I2781	4.42	No	No	0	9	8
176	R:R:K2940	R:R:M2989	4.32	Yes	No	0	9	9
177	R:R:I2982	R:R:L2758	4.28	No	Yes	0	9	9
178	R:R:I2796	R:R:L2800	4.28	No	Yes	0	4	4
179	R:R:L2939	R:R:M2943	4.24	No	No	0	6	4
180	R:R:D2938	R:R:I2935	4.2	No	No	0	8	8
181	R:R:L2758	R:R:L2787	4.15	Yes	No	0	9	9
182	R:R:L2910	R:R:L2951	4.15	No	No	0	4	8
183	R:R:L2968	R:R:N2965	4.12	No	No	0	7	7
184	R:R:K2770	R:R:Q2996	4.07	No	No	0	7	9
185	R:R:G2961	R:R:P2962	4.06	No	No	0	9	9
186	R:R:F2853	R:R:V2832	3.93	Yes	No	0	8	8
187	R:R:H2986	R:R:K2990	3.93	No	No	0	6	9
188	R:R:V2869	R:R:Y2876	3.79	No	Yes	0	6	8
189	R:R:F2974	R:R:I2973	3.77	Yes	No	0	5	8
190	R:R:T2747	R:R:Y2748	3.75	No	No	0	9	7
191	R:R:G2979	R:R:S2754	3.71	No	No	0	9	9
192	R:R:T2785	R:R:W2858	3.64	No	Yes	0	7	6
193	R:R:A2761	R:R:C2987	3.61	No	No	0	7	8
194	R:R:G2828	R:R:I2905	3.53	No	No	0	8	7
195	R:R:G2950	R:R:M2827	3.49	No	Yes	0	9	9
196	R:R:A2815	R:R:V2793	3.39	No	No	0	6	5
197	R:R:C2809	R:R:T2878	3.38	No	No	4	8	5
198	R:R:C2886	R:R:T2878	3.38	No	No	4	8	5
199	R:R:A2972	R:R:T2747	3.36	No	No	0	9	9
200	R:R:A2972	R:R:I2746	3.25	No	No	0	9	9
201	R:R:A2956	R:R:M2728	3.22	No	Yes	0	9	8
202	R:R:A2831	R:R:M2908	3.22	No	No	0	8	3
203	R:R:A2831	R:R:M2912	3.22	No	No	0	8	8
204	R:R:G2725	R:R:H2723	3.18	No	Yes	0	9	9
205	R:R:A2812	R:R:L2800	3.15	No	Yes	0	6	4
206	R:R:A2959	R:R:L2968	3.15	No	No	0	9	7
207	R:R:A2812	R:R:N2797	3.13	No	No	0	6	8
208	R:R:L2788	R:R:S2755	3	No	No	0	9	9
209	R:R:L2968	R:R:V2735	2.98	No	No	0	7	8
210	R:R:L2838	R:R:V2916	2.98	No	No	0	8	9
211	R:R:L2800	R:R:T2811	2.95	Yes	No	0	4	6
212	R:R:I2905	R:R:M2908	2.92	No	No	0	7	3
213	R:R:I2846	R:R:K2852	2.91	No	No	0	7	9
214	R:R:I2844	R:R:L2836	2.85	No	No	0	8	5
215	R:R:I2742	R:R:N2739	2.83	No	No	0	8	9
216	R:R:L2821	R:R:M2864	2.83	No	No	0	9	5
217	R:R:K2852	R:R:N2848	2.8	No	No	0	9	8
218	R:R:C2903	R:R:F2957	2.79	No	No	0	7	8
219	R:R:L2851	R:R:L2855	2.77	No	No	0	5	6
220	R:R:D2874	R:R:K2889	2.77	No	No	0	9	9
221	R:R:A2744	R:R:Y2748	2.67	No	No	0	5	7
222	R:R:M2963	R:R:R2964	2.48	No	No	0	8	8
223	R:R:F2967	R:R:L2970	2.44	No	No	0	8	9
224	R:R:L2936	R:R:R2932	2.43	No	No	0	8	4
225	R:R:D2891	R:R:Y2895	2.3	No	No	0	9	8
226	R:R:C2809	R:R:G2877	1.96	No	No	4	8	9
227	R:R:C2886	R:R:G2877	1.96	No	No	4	8	9
228	R:R:A2813	R:R:G2877	1.95	No	No	0	8	9
229	R:R:A2862	R:R:G2859	1.95	No	No	0	8	9
230	R:R:G2807	R:R:V2806	1.84	No	No	0	5	1
231	R:R:G2750	R:R:T2749	1.82	No	No	0	9	5
232	R:R:G2750	R:R:T2976	1.82	No	No	0	9	7
233	R:R:G2807	R:R:I2810	1.76	No	No	0	5	5
234	R:R:P2884	R:R:T2878	1.75	No	No	0	4	5
235	R:R:G2941	R:R:L2920	1.71	No	No	0	8	8
236	R:R:A2813	R:R:I2810	1.62	No	No	0	8	5
237	R:R:A2900	R:R:I2896	1.62	No	No	0	8	5
238	R:R:S2922	R:R:V2923	1.62	No	No	0	9	6
239	R:R:D2774	R:R:P2776	1.61	No	No	0	9	9
240	R:R:A2777	R:R:K2990	1.61	No	No	0	9	9
241	R:R:C2914	R:R:L2910	1.59	No	No	0	8	4
242	R:R:T2915	R:R:V2918	1.59	No	No	0	6	4
243	R:R:I2867	R:R:S2870	1.55	No	No	0	5	6
244	R:R:I2896	R:R:S2897	1.55	No	No	0	5	9
245	R:R:M2912	R:R:S2911	1.53	No	No	0	8	7
246	R:R:K2873	R:R:V2871	1.52	No	No	0	8	8
247	R:R:D2729	R:R:S2731	1.47	No	No	0	9	9
248	R:R:I2863	R:R:I2867	1.47	No	No	0	7	5
249	R:R:I2867	R:R:M2864	1.46	No	No	0	5	5
250	R:R:Q2919	R:R:V2918	1.43	No	No	0	9	4
251	R:R:K2933	R:R:L2936	1.41	No	No	0	6	8
252	R:R:G2961	R:R:W2960	1.41	No	No	0	9	8
253	R:R:P2847	R:R:Y2845	1.39	No	No	0	7	8
254	R:R:L2851	R:R:N2848	1.37	No	No	0	5	8
255	R:R:D2938	R:R:L2917	1.36	No	No	0	8	6
256	R:R:D2938	R:R:L2939	1.36	No	No	0	8	6
257	R:R:F2757	R:R:V2760	1.31	Yes	No	5	9	6
258	R:R:F2983	R:R:V2760	1.31	Yes	No	5	9	6
259	R:R:H2937	R:R:K2940	1.31	No	Yes	0	4	9
260	R:R:R2994	R:R:V2993	1.31	No	No	0	8	8
261	R:R:I2935	R:R:R2931	1.25	No	No	0	8	5
262	R:R:F2842	R:R:N2843	1.21	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H2723	4.885	4	0	9
2	R:R:F2724	9.215	4	0	9
3	R:R:M2728	6.204	5	1	8
4	R:R:F2757	6.67	5	5	9
5	R:R:L2758	5.77	4	0	9
6	R:R:Y2765	6.545	4	0	8
7	R:R:Y2775	16.694	5	3	5
8	R:R:I2779	8.645	4	3	9
9	R:R:L2800	4.4575	4	0	4
10	R:R:L2816	6.7025	4	0	9
11	R:R:H2817	8.76333	6	2	9
12	R:R:Y2818	7.535	4	7	8
13	R:R:W2826	11.196	5	0	8
14	R:R:M2827	5.49	4	0	9
15	R:R:Y2849	14.4875	4	3	8
16	R:R:F2853	8.972	5	3	8
17	R:R:W2858	8.392	5	7	6
18	R:R:Y2876	8.046	5	2	8
19	R:R:F2885	10.2125	4	0	7
20	R:R:W2887	8.17	5	2	8
21	R:R:I2888	9.374	5	2	9
22	R:R:F2894	8.2325	4	2	9
23	R:R:K2940	3.8625	4	0	9
24	R:R:F2947	10.775	4	1	9
25	R:R:T2952	8.03	4	1	9
26	R:R:W2953	11.25	6	1	8
27	R:R:F2974	5.835	4	1	5
28	R:R:Q2978	8.5625	4	0	9
29	R:R:F2983	6.9875	4	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E2740	R:R:T2722	46.7433	8.47	No	No	0	9	9
2	R:R:F2885	R:R:T2722	48.7032	14.27	Yes	No	0	7	9
3	R:R:E2740	R:R:H2723	40.2797	4.92	No	Yes	0	9	9
4	R:R:H2723	R:R:L2743	31.7431	5.14	Yes	No	0	9	8
5	R:R:F2885	R:R:N2797	15.3714	8.46	Yes	No	0	7	8
6	R:R:L2816	R:R:N2797	19.8977	5.49	Yes	No	0	9	8
7	R:R:F2794	R:R:L2816	49.8936	8.53	No	Yes	0	8	9
8	R:R:F2724	R:R:F2794	82.2478	7.5	Yes	No	0	9	8
9	R:R:F2885	R:R:W2887	47.7527	5.01	Yes	Yes	0	7	8
10	R:R:L2816	R:R:W2887	40.7233	6.83	Yes	Yes	0	9	8
11	R:R:L2727	R:R:W2887	79.5908	10.25	No	Yes	0	9	8
12	R:R:F2794	R:R:L2727	35.3189	7.31	No	No	0	8	9
13	R:R:F2724	R:R:T2747	13.7057	6.49	Yes	No	0	9	9
14	R:R:F2724	R:R:W2953	72.8149	6.01	Yes	Yes	0	9	8
15	R:R:L2727	R:R:L2820	46.9108	5.54	No	No	0	9	8
16	R:R:F2824	R:R:L2820	46.3903	12.18	No	No	0	7	8
17	R:R:F2824	R:R:W2953	33.0105	16.04	No	Yes	0	7	8
18	R:R:F2824	R:R:F2902	23.297	22.51	No	No	0	7	9
19	R:R:M2728	R:R:W2953	27.7961	5.82	Yes	Yes	1	8	8
20	R:R:F2902	R:R:M2728	11.9812	11.2	No	Yes	0	9	8
21	R:R:M2728	R:R:V2899	23.1883	4.56	Yes	No	0	8	9
22	R:R:L2743	R:R:Y2969	29.5342	7.03	No	No	0	8	8
23	R:R:N2739	R:R:Y2969	13.8189	11.63	No	No	0	9	8
24	R:R:N2791	R:R:S2754	15.1405	5.96	No	No	0	9	9
25	R:R:G2979	R:R:S2754	17.2679	3.71	No	No	0	9	9
26	R:R:G2979	R:R:L2758	19.3862	5.13	No	Yes	0	9	9
27	R:R:L2758	R:R:L2787	25.6869	4.15	Yes	No	0	9	9
28	R:R:L2787	R:R:Q2978	27.769	9.32	No	Yes	0	9	9
29	R:R:Q2978	R:R:W2953	76.8207	8.76	Yes	Yes	0	9	8
30	R:R:F2947	R:R:Q2978	53.7636	9.37	Yes	Yes	0	9	9
31	R:R:F2947	R:R:F2981	51.5548	19.29	Yes	No	0	9	4
32	R:R:F2981	R:R:L2977	50.4232	9.74	No	No	0	4	7
33	R:R:F2980	R:R:L2977	49.3505	8.53	No	No	0	9	7
34	R:R:F2757	R:R:F2980	40.583	6.43	Yes	No	0	9	9
35	R:R:F2757	R:R:F2983	34.1239	11.79	Yes	Yes	5	9	9
36	R:R:C2987	R:R:F2983	33.0195	6.98	No	Yes	0	8	9
37	R:R:C2987	R:R:Y2765	31.1682	8.06	No	Yes	0	8	8
38	R:R:V2993	R:R:Y2765	14.1764	5.05	No	Yes	0	8	8
39	R:R:L2780	R:R:Y2765	23.9578	7.03	No	Yes	0	8	8
40	R:R:I2888	R:R:W2887	100	11.74	Yes	Yes	2	9	8
41	R:R:H2817	R:R:I2888	78.9164	10.61	Yes	Yes	2	9	9
42	R:R:H2817	R:R:L2821	79.3781	5.14	Yes	No	0	9	9
43	R:R:L2821	R:R:Y2901	73.0096	7.03	No	No	0	9	8
44	R:R:T2825	R:R:Y2901	61.0872	4.99	No	No	0	7	8
45	R:R:P2861	R:R:T2825	59.2857	5.25	No	No	0	9	7
46	R:R:P2861	R:R:V2822	58.548	5.3	No	No	0	9	6
47	R:R:V2822	R:R:W2858	51.9712	12.26	No	Yes	7	6	6
48	R:R:W2826	R:R:W2858	51.1293	13.12	Yes	Yes	0	8	6
49	R:R:I2779	R:R:W2826	37.1656	8.22	Yes	Yes	0	9	8
50	R:R:E2830	R:R:I2779	24.2882	6.83	No	Yes	0	8	9
51	R:R:E2830	R:R:L2948	24.0076	14.58	No	No	0	8	9
52	R:R:H2986	R:R:L2948	23.8628	19.28	No	No	0	6	9
53	R:R:H2986	R:R:L2780	23.6048	5.14	No	No	0	6	8
54	R:R:I2779	R:R:Y2775	23.1748	14.51	Yes	Yes	3	9	5
55	R:R:Y2775	R:R:Y2849	12.5243	27.8	Yes	Yes	3	5	8
56	R:R:F2853	R:R:I2779	15.5886	5.02	Yes	Yes	3	8	9
57	R:R:F2853	R:R:Y2849	20.7894	13.41	Yes	Yes	3	8	8
58	R:R:L2829	R:R:W2826	14.3394	9.11	No	Yes	0	8	8
59	R:R:F2853	R:R:L2829	11.2117	12.18	Yes	No	0	8	8
60	R:R:A2812	R:R:N2797	14.7286	3.13	No	No	0	6	8
61	R:R:A2812	R:R:L2800	12.6511	3.15	No	Yes	0	6	4
62	R:R:A2813	R:R:G2877	12.7009	1.95	No	No	0	8	9
63	R:R:A2813	R:R:I2810	14.4797	1.62	No	No	0	8	5
64	R:R:I2810	R:R:Y2876	19.7619	4.84	No	Yes	0	5	8
65	R:R:I2888	R:R:Y2876	18.1189	10.88	Yes	Yes	2	9	8
66	R:R:F2902	R:R:F2906	22.2378	8.57	No	No	0	9	9
67	R:R:F2906	R:R:N2909	19.1418	6.04	No	No	0	9	9
68	R:R:L2949	R:R:N2909	17.6481	5.49	No	No	0	9	9
69	R:R:I2905	R:R:Y2901	20.812	10.88	No	No	0	7	8
70	R:R:I2905	R:R:M2908	17.3992	2.92	No	No	0	7	3
71	R:R:A2831	R:R:M2908	15.6792	3.22	No	No	0	8	3
72	R:R:A2831	R:R:M2912	13.9501	3.22	No	No	0	8	8
73	R:R:M2912	R:R:Y2835	10.4603	8.38	No	No	0	8	8
74	R:R:I2846	R:R:Y2849	23.641	10.88	No	Yes	0	7	8
75	R:R:L2945	R:R:L2949	12.4519	5.54	No	No	0	9	9
76	R:R:F2913	R:R:L2945	11.4471	10.96	No	No	0	9	9
77	R:R:F2980	R:R:V2984	22.6225	7.87	No	No	0	9	8
78	R:R:F2985	R:R:V2984	20.8799	7.87	No	No	0	9	8
79	R:R:F2985	R:R:M2989	11.2434	6.22	No	No	0	9	9
80	R:R:F2966	R:R:Y2969	13.8189	7.22	No	No	0	3	8
81	R:R:F2966	R:R:L2970	11.5376	8.53	No	No	0	3	9
82	R:R:L2821	R:R:M2864	10.8586	2.83	No	No	0	9	5
83	R:R:I2846	R:R:K2852	13.7691	2.91	No	No	0	7	9
84	R:R:K2852	R:R:N2848	10.3426	2.8	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7WUJ_nogp

PDB Summary
PDB	7WUJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.91
Number of Linked Nodes	246
Number of Links	262
Number of Hubs	29
Number of Links mediated by Hubs	104
Number of Communities	7
Number of Nodes involved in Communities	31
Number of Links involved in Communities	38

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	52005
Length Of Smallest Path	3
Average Path Length	14.953
Length of Longest Path	30
Minimum Path Strength	1.36
Average Path Strength	8.09856
Maximum Path Strength	23.605
Minimum Path Correlation	0.7
Average Path Correlation	0.924668
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.6629
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.1491
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8IZF6
Sequence	>7WUJ_nogp_Chain_R T H F G V L M D L S R S T V S V N E Q I L A L I T Y T G C G I S S I F L G V A V V T Y I A F H K L R K D Y P A K I L I N L C T A L L M L N L V F L I N S W L S S F Q K V G V C I T A A V A L H Y F L L V S F T W M G L E A V H M Y L A L V K V F N I Y I P N Y I L K F C L V G W G I P A I M V A I T V S V K K D L Y G T P F C W I K D D S I F Y I S V V A Y F C L I F L M N L S M F C T V L V Q L N S V K S R R K M I L H D L K G T M S L T F L L G L T W G F A F F A W G P M R N F F L Y L F A I F N T L Q G F F I F V F H C V M K E S V R E Q W Q I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WUJ	B2	Adhesion	Adhesion	ADGRG4	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2022-04-27	10.1038/s41586-022-04590-8
	7WUJ (No Gprot)	B2	Adhesion	Adhesion	ADGRG4	Homo sapiens	-	-		3.3	2022-04-27	10.1038/s41586-022-04590-8

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