Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:H2723 4.885409
2R:R:F2724 9.215409
3R:R:M2728 6.204518
4R:R:F2757 6.67559
5R:R:L2758 5.77409
6R:R:Y2765 6.545408
7R:R:Y2775 16.694535
8R:R:I2779 8.645439
9R:R:L2800 4.4575404
10R:R:L2816 6.7025409
11R:R:H2817 8.76333629
12R:R:Y2818 7.535478
13R:R:W2826 11.196508
14R:R:M2827 5.49409
15R:R:Y2849 14.4875438
16R:R:F2853 8.972538
17R:R:W2858 8.392576
18R:R:Y2876 8.046528
19R:R:F2885 10.2125407
20R:R:W2887 8.17528
21R:R:I2888 9.374529
22R:R:F2894 8.2325429
23R:R:K2940 3.8625409
24R:R:F2947 10.775419
25R:R:T2952 8.03419
26R:R:W2953 11.25618
27R:R:F2974 5.835415
28R:R:Q2978 8.5625409
29R:R:F2983 6.9875459
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E2740 R:R:T2722 46.74338.47NoNo099
2R:R:F2885 R:R:T2722 48.703214.27YesNo079
3R:R:E2740 R:R:H2723 40.27974.92NoYes099
4R:R:H2723 R:R:L2743 31.74315.14YesNo098
5R:R:F2885 R:R:N2797 15.37148.46YesNo078
6R:R:L2816 R:R:N2797 19.89775.49YesNo098
7R:R:F2794 R:R:L2816 49.89368.53NoYes089
8R:R:F2724 R:R:F2794 82.24787.5YesNo098
9R:R:F2885 R:R:W2887 47.75275.01YesYes078
10R:R:L2816 R:R:W2887 40.72336.83YesYes098
11R:R:L2727 R:R:W2887 79.590810.25NoYes098
12R:R:F2794 R:R:L2727 35.31897.31NoNo089
13R:R:F2724 R:R:T2747 13.70576.49YesNo099
14R:R:F2724 R:R:W2953 72.81496.01YesYes098
15R:R:L2727 R:R:L2820 46.91085.54NoNo098
16R:R:F2824 R:R:L2820 46.390312.18NoNo078
17R:R:F2824 R:R:W2953 33.010516.04NoYes078
18R:R:F2824 R:R:F2902 23.29722.51NoNo079
19R:R:M2728 R:R:W2953 27.79615.82YesYes188
20R:R:F2902 R:R:M2728 11.981211.2NoYes098
21R:R:M2728 R:R:V2899 23.18834.56YesNo089
22R:R:L2743 R:R:Y2969 29.53427.03NoNo088
23R:R:N2739 R:R:Y2969 13.818911.63NoNo098
24R:R:N2791 R:R:S2754 15.14055.96NoNo099
25R:R:G2979 R:R:S2754 17.26793.71NoNo099
26R:R:G2979 R:R:L2758 19.38625.13NoYes099
27R:R:L2758 R:R:L2787 25.68694.15YesNo099
28R:R:L2787 R:R:Q2978 27.7699.32NoYes099
29R:R:Q2978 R:R:W2953 76.82078.76YesYes098
30R:R:F2947 R:R:Q2978 53.76369.37YesYes099
31R:R:F2947 R:R:F2981 51.554819.29YesNo094
32R:R:F2981 R:R:L2977 50.42329.74NoNo047
33R:R:F2980 R:R:L2977 49.35058.53NoNo097
34R:R:F2757 R:R:F2980 40.5836.43YesNo099
35R:R:F2757 R:R:F2983 34.123911.79YesYes599
36R:R:C2987 R:R:F2983 33.01956.98NoYes089
37R:R:C2987 R:R:Y2765 31.16828.06NoYes088
38R:R:V2993 R:R:Y2765 14.17645.05NoYes088
39R:R:L2780 R:R:Y2765 23.95787.03NoYes088
40R:R:I2888 R:R:W2887 10011.74YesYes298
41R:R:H2817 R:R:I2888 78.916410.61YesYes299
42R:R:H2817 R:R:L2821 79.37815.14YesNo099
43R:R:L2821 R:R:Y2901 73.00967.03NoNo098
44R:R:T2825 R:R:Y2901 61.08724.99NoNo078
45R:R:P2861 R:R:T2825 59.28575.25NoNo097
46R:R:P2861 R:R:V2822 58.5485.3NoNo096
47R:R:V2822 R:R:W2858 51.971212.26NoYes766
48R:R:W2826 R:R:W2858 51.129313.12YesYes086
49R:R:I2779 R:R:W2826 37.16568.22YesYes098
50R:R:E2830 R:R:I2779 24.28826.83NoYes089
51R:R:E2830 R:R:L2948 24.007614.58NoNo089
52R:R:H2986 R:R:L2948 23.862819.28NoNo069
53R:R:H2986 R:R:L2780 23.60485.14NoNo068
54R:R:I2779 R:R:Y2775 23.174814.51YesYes395
55R:R:Y2775 R:R:Y2849 12.524327.8YesYes358
56R:R:F2853 R:R:I2779 15.58865.02YesYes389
57R:R:F2853 R:R:Y2849 20.789413.41YesYes388
58R:R:L2829 R:R:W2826 14.33949.11NoYes088
59R:R:F2853 R:R:L2829 11.211712.18YesNo088
60R:R:A2812 R:R:N2797 14.72863.13NoNo068
61R:R:A2812 R:R:L2800 12.65113.15NoYes064
62R:R:A2813 R:R:G2877 12.70091.95NoNo089
63R:R:A2813 R:R:I2810 14.47971.62NoNo085
64R:R:I2810 R:R:Y2876 19.76194.84NoYes058
65R:R:I2888 R:R:Y2876 18.118910.88YesYes298
66R:R:F2902 R:R:F2906 22.23788.57NoNo099
67R:R:F2906 R:R:N2909 19.14186.04NoNo099
68R:R:L2949 R:R:N2909 17.64815.49NoNo099
69R:R:I2905 R:R:Y2901 20.81210.88NoNo078
70R:R:I2905 R:R:M2908 17.39922.92NoNo073
71R:R:A2831 R:R:M2908 15.67923.22NoNo083
72R:R:A2831 R:R:M2912 13.95013.22NoNo088
73R:R:M2912 R:R:Y2835 10.46038.38NoNo088
74R:R:I2846 R:R:Y2849 23.64110.88NoYes078
75R:R:L2945 R:R:L2949 12.45195.54NoNo099
76R:R:F2913 R:R:L2945 11.447110.96NoNo099
77R:R:F2980 R:R:V2984 22.62257.87NoNo098
78R:R:F2985 R:R:V2984 20.87997.87NoNo098
79R:R:F2985 R:R:M2989 11.24346.22NoNo099
80R:R:F2966 R:R:Y2969 13.81897.22NoNo038
81R:R:F2966 R:R:L2970 11.53768.53NoNo039
82R:R:L2821 R:R:M2864 10.85862.83NoNo095
83R:R:I2846 R:R:K2852 13.76912.91NoNo079
84R:R:K2852 R:R:N2848 10.34262.8NoNo098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WUJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 4.91
Number of Linked Nodes 246
Number of Links 262
Number of Hubs 29
Number of Links mediated by Hubs 104
Number of Communities 7
Number of Nodes involved in Communities 31
Number of Links involved in Communities 38
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 52005
Length Of Smallest Path 3
Average Path Length 14.953
Length of Longest Path 30
Minimum Path Strength 1.36
Average Path Strength 8.09856
Maximum Path Strength 23.605
Minimum Path Correlation 0.7
Average Path Correlation 0.924689
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 44.6629
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.1491
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8IZF6
Sequence
>7WUJ_nogp_Chain_R
THFGVLMDL SRSTVSVNE QILALITYT GCGISSIFL GVAVVTYIA 
FHKLRKDYP AKILINLCT ALLMLNLVF LINSWLSSF QKVGVCITA 
AVALHYFLL VSFTWMGLE AVHMYLALV KVFNIYIPN YILKFCLVG 
WGIPAIMVA ITVSVKKDL YGTPFCWIK DDSIFYISV VAYFCLIFL 
MNLSMFCTV LVQLNSVKS RRKMILHDL KGTMSLTFL LGLTWGFAF 
FAWGPMRNF FLYLFAIFN TLQGFFIFV FHCVMKESV REQWQI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WUJB2AdhesionAdhesionADGRG4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32022-04-27doi.org/10.1038/s41586-022-04590-8
7WUJ (No Gprot) B2AdhesionAdhesionADGRG4Homo sapiens--3.32022-04-27doi.org/10.1038/s41586-022-04590-8




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Download 7WUJ_nogp.zip



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