Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L23 3.55426
2A:A:L37 4.7325409
3A:A:L38 5.61254178
4A:A:L39 3.4925419
5A:A:K46 5.715179
6A:A:I49 4.9725457
7A:A:F191 9.66754135
8A:A:L194 5.214134
9A:A:F196 7.3785137
10A:A:F199 5.78333615
11A:A:D200 5.334179
12A:A:V201 4.082519
13A:A:Q204 3.936519
14A:A:R208 4.724519
15A:A:K210 5.972519
16A:A:W211 5.386519
17A:A:H213 5.545418
18A:A:C214 4.5425417
19A:A:F215 6.858519
20A:A:I222 2.894177
21A:A:F223 6.625409
22A:A:Y230 5.64667658
23A:A:M243 3.3825408
24A:A:F250 7.3954149
25A:A:C254 4.9554145
26A:A:N256 5.4925418
27A:A:W258 8.62515
28A:A:F259 6.3025419
29A:A:I264 4.26754146
30A:A:I265 3.3025408
31A:A:L266 4.705409
32A:A:F267 5.448559
33A:A:L268 6.42408
34A:A:N269 4.99559
35A:A:K270 4.8425459
36A:A:F274 6.375409
37A:A:C286 3.138506
38A:A:Y287 4.96607
39A:A:Y290 9.3175407
40A:A:Y296 4.898336214
41A:A:I303 3.895407
42A:A:F307 3.77408
43A:A:N311 4.7525148
44A:A:R313 6.9654144
45A:A:K317 5.564147
46A:A:T324 6.524559
47A:A:F336 5.728336138
48A:A:K345 6.44155
49A:A:L348 3.685109
50A:A:L353 5.18254107
51B:B:L14 3.4675408
52B:B:V40 5.535673
53B:B:L51 6.59529
54B:B:H54 8.04667629
55B:B:K57 8.265419
56B:B:Y59 9.05333618
57B:B:M61 5.1775426
58B:B:W63 8.14527
59B:B:L70 6.66425
60B:B:Q75 6.855419
61B:B:I80 11.22428
62B:B:W82 10.5314729
63B:B:Y85 9.59524
64B:B:N88 3.3725407
65B:B:K89 6.46714729
66B:B:L95 6.64118
67B:B:W99 7.97667619
68B:B:Y105 4.65506
69B:B:Y111 7.0025404
70B:B:C114 3.1765118
71B:B:I123 3.57406
72B:B:Y124 7.0056116
73B:B:T128 4.854223
74B:B:E130 4.70754223
75B:B:H142 8.086569
76B:B:Y145 4.508518
77B:B:F151 6.142509
78B:B:L152 3.092543
79B:B:T159 5.4175469
80B:B:D163 6.824569
81B:B:T165 3.7375467
82B:B:L168 4.505446
83B:B:W169 10.278568
84B:B:H183 8.07667649
85B:B:V187 5.145449
86B:B:L190 4.812545
87B:B:S201 4.62449
88B:B:C204 4.798517
89B:B:D205 7.7475449
90B:B:S207 4.875445
91B:B:W211 12.74408
92B:B:H225 6.99667619
93B:B:D228 6.9575419
94B:B:I229 4.76517
95B:B:I232 3.62667618
96B:B:F235 7.86167686
97B:B:N237 10.765485
98B:B:N239 6.0075482
99B:B:F241 5.65333616
100B:B:S245 5.5625419
101B:B:D246 6.885419
102B:B:F253 7.9475416
103B:B:D254 4.26689
104B:B:R256 4.848589
105B:B:Y264 4.8505
106B:B:H266 6.41254124
107B:B:I269 3.73254124
108B:B:F278 6.035487
109B:B:R283 6.84679
110B:B:L284 4.7275475
111B:B:L285 4.41586
112B:B:N295 6.268336126
113B:B:D298 8.974579
114B:B:L300 3.3275476
115B:B:R304 6.574125
116B:B:H311 7.235699
117B:B:R314 12.4825418
118B:B:W332 11.5633619
119B:B:D333 8.4325499
120B:B:L336 4.06427
121B:B:K337 6.104596
122B:B:W339 8.84167699
123G:G:I9 1.442502
124G:G:L19 3.5225409
125G:G:K29 6.8825404
126G:G:Y40 12.97486
127G:G:D48 6.694579
128G:G:P49 3.415407
129G:G:L51 2.98143776
130G:G:F61 5.426528
131R:R:Y41 5.4854167
132R:R:I58 3.2954248
133R:R:R66 2.645407
134R:R:M68 9.30254186
135R:R:T69 4.484188
136R:R:N70 7.015408
137R:R:Y72 8.3285187
138R:R:L76 5.99439
139R:R:D80 5.522539
140R:R:L84 3.575406
141R:R:W99 10.4925409
142R:R:F112 5.09404
143R:R:Y113 6.065166
144R:R:Y118 2.4525407
145R:R:S119 4.53437
146R:R:I121 4.455438
147R:R:F123 8.77437
148R:R:D130 9.22754188
149R:R:I135 5.5585108
150R:R:R145 6.23754187
151R:R:W158 5.744539
152R:R:Y187 8.334195
153R:R:T191 3.65754193
154R:R:W195 5.6645192
155R:R:C207 3.65436
156R:R:P211 3.65439
157R:R:M215 6.39438
158R:R:Y219 9.675439
159R:R:L226 3.425108
160R:R:F248 6.1375439
161R:R:W252 7.27571739
162R:R:Y255 2.735407
163R:R:Q265 3.6575404
164R:R:N297 8.625439
165R:R:Y301 7.1325409
166R:R:R307 4.5654157
167R:R:F308 4.6185248
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G:G:D48 G:G:L51 10.09235.43YesYes796
2B:B:R283 G:G:L51 10.86773.64YesYes796
3B:B:L300 B:B:R283 11.73896.07YesYes769
4B:B:A299 B:B:L300 13.29031.58NoYes056
5B:B:A299 B:B:L285 13.36091.58NoYes056
6B:B:L285 B:B:Y264 14.44577.03YesYes065
7B:B:W297 B:B:Y264 15.91096.75NoYes085
8B:B:N295 B:B:W297 15.97316.78YesNo1268
9B:B:N293 B:B:N295 17.06124.09NoYes056
10B:B:D291 B:B:N293 17.13188.08NoNo085
11B:B:C271 B:B:D291 17.20264.67NoNo058
12B:B:C271 B:B:D290 17.34433.11NoNo056
13B:B:D290 B:B:R314 17.407319.06NoYes168
14A:A:C214 B:B:W99 11.75323.92YesYes179
15B:B:L117 B:B:W99 17.61495.69NoYes199
16B:B:L117 B:B:Y145 17.50263.52NoYes198
17B:B:M188 B:B:Y145 1003.59NoYes188
18A:A:K210 B:B:M188 66.58917.2YesNo198
19A:A:K210 B:B:D228 33.23388.3YesYes199
20B:B:D228 B:B:S227 66.36594.42YesNo196
21B:B:S227 B:B:S245 99.35213.26NoYes169
22B:B:H225 B:B:S245 50.77065.58YesYes199
23B:B:F253 B:B:H225 48.22034.53YesYes169
24B:B:F241 B:B:F253 43.91448.57YesYes166
25B:B:F241 B:B:L255 87.08352.44YesNo066
26B:B:L210 B:B:L255 86.69165.54NoNo056
27B:B:L198 B:B:L210 86.29964.15NoNo035
28B:B:D212 B:B:L198 85.90775.43NoNo093
29B:B:D212 B:B:R219 85.12378.34NoNo095
30B:B:M217 B:B:R219 84.33963.72NoNo035
31B:B:M217 G:G:Q18 83.55555.44NoNo039
32B:B:C218 G:G:Q18 83.16347.63NoNo059
33B:B:C218 B:B:F180 60.30622.79NoNo057
34B:B:C166 B:B:F180 17.73875.59NoNo087
35B:B:C166 B:B:S201 16.16223.44NoYes489
36B:B:L190 B:B:S201 31.54723YesYes459
37B:B:C148 B:B:L190 46.14984.76NoYes065
38B:B:C148 B:B:R150 42.60085.57NoNo066
39B:B:H62 B:B:R150 41.41774.51NoNo066
40B:B:H62 B:B:Y105 40.23534.36NoYes066
41B:B:V71 B:B:Y105 34.31953.79NoYes086
42B:B:I81 B:B:V71 31.95343.07NoNo078
43B:B:I81 B:B:V90 28.40374.61NoNo075
44B:B:H91 B:B:V90 27.22055.54NoNo055
45B:B:R314 B:B:W332 13.70722.99YesYes189
46B:B:C204 B:B:M188 33.36013.24YesNo178
47B:B:C204 B:B:D228 33.258412.45YesYes179
48A:A:K210 B:B:D246 33.23395.53YesYes199
49B:B:D246 B:B:S227 33.1785.89YesNo196
50B:B:I229 B:B:S245 47.6223.1YesYes179
51B:B:I229 B:B:I232 47.03732.94YesYes178
52B:B:F241 B:B:I232 43.89745.02YesYes168
53B:B:C218 B:B:K209 22.46784.85NoNo056
54B:B:H183 B:B:K209 20.105318.34YesNo096
55B:B:H183 B:B:S201 16.1735.58YesYes499
56B:B:F180 B:B:W211 42.177832.07NoYes078
57B:B:F199 B:B:W211 37.056510.02NoYes098
58B:B:F199 B:B:L190 15.77117.31NoYes495
59R:R:N70 R:R:T69 78.14514.39YesYes088
60R:R:N70 R:R:R63 81.50319.64YesNo086
61R:R:R63 R:R:Y311 81.762118.52NoNo064
62R:R:R307 R:R:Y311 82.02126.17YesNo074
63A:A:K349 R:R:R307 82.79873.71NoYes1557
64A:A:K345 A:A:K349 83.03084.31YesNo1555
65A:A:E318 A:A:K345 42.169410.8NoYes045
66A:A:E318 A:A:Y320 42.42344.49NoNo047
67A:A:S263 A:A:Y320 85.36965.09NoNo077
68A:A:S263 A:A:V342 85.49343.23NoNo077
69A:A:T219 A:A:V342 85.61733.17NoNo077
70A:A:T219 A:A:V34 85.74166.35NoNo075
71A:A:L194 A:A:V34 42.9154.47YesNo045
72A:A:D341 A:A:K345 42.18915.53NoYes085
73A:A:D341 A:A:Y320 42.82414.94NoNo087
74A:A:V339 A:A:V34 42.95253.21NoNo085
75A:A:F223 A:A:I253 45.85133.77YesNo098
76A:A:F223 A:A:V225 87.40673.93YesNo097
77A:A:F307 A:A:V225 86.53343.93YesNo087
78A:A:F307 A:A:I303 86.42323.77YesYes087
79A:A:I303 A:A:M243 86.34652.92YesYes078
80A:A:D229 A:A:M243 86.93712.77NoYes088
81A:A:A226 A:A:D229 86.91724.63NoNo088
82A:A:A226 A:A:K270 86.91094.82NoYes089
83A:A:K270 A:A:N269 88.33784.2YesYes599
84A:A:I49 A:A:N269 44.12485.66YesYes579
85A:A:F267 A:A:I49 44.04326.28YesYes597
86A:A:N269 A:A:T324 44.15955.85YesYes599
87A:A:F267 A:A:T324 44.07177.78YesYes599
88A:A:F267 A:A:V335 86.69912.62YesNo098
89A:A:F196 A:A:V335 86.64372.62YesNo078
90B:B:F199 B:B:V158 20.89215.24NoNo495
91B:B:L152 B:B:V158 20.53162.98YesNo435
92B:B:L152 B:B:T196 18.95452.95YesNo031
93B:B:D153 B:B:T196 18.56017.23NoNo051
94B:B:D153 B:B:P107 18.16563.22NoNo056
95B:B:F151 B:B:P107 17.37672.89YesNo096
96B:B:F151 B:B:I157 15.798512.56YesNo097
97B:B:I123 B:B:I157 15.00932.94YesNo067
98A:A:R208 A:A:W211 84.68454YesYes199
99A:A:S206 A:A:W211 83.09587.41NoYes089
100A:A:S206 B:B:Y145 83.05615.09NoYes088
101A:A:L249 A:A:R208 42.4316.07NoYes099
102A:A:C351 R:R:T69 65.8176.76NoYes048
103A:A:C351 R:R:R131 65.54965.57NoNo049
104A:A:L353 R:R:R131 10.82112.15YesNo079
105B:B:H91 B:B:V133 24.85394.15NoNo054
106B:B:V133 B:B:Y124 21.30353.79NoYes1146
107R:R:R131 R:R:Y301 54.51868.23NoYes099
108R:R:I124 R:R:Y301 51.61418.46NoYes089
109R:R:I124 R:R:N297 39.71635.66NoYes389
110R:R:H293 R:R:N297 28.124316.58NoYes399
111R:R:H293 R:R:W252 26.76548.46NoYes399
112R:R:C207 R:R:W252 16.83523.92YesYes369
113R:R:C207 R:R:Y118 16.57962.69YesYes067
114R:R:M203 R:R:Y118 15.76592.39NoYes057
115R:R:I124 R:R:L76 11.62955.71NoYes389
116R:R:D80 R:R:L76 11.39114.07YesYes399
117R:R:D80 R:R:E120 13.0285.2YesNo099
118R:R:E120 R:R:L117 12.4766.63NoNo097
119R:R:F83 R:R:L117 11.933812.18NoNo077
120R:R:F83 R:R:Y113 10.84917.22NoYes1676
121R:R:D80 R:R:N297 11.35585.39YesYes399
122A:A:F196 A:A:L194 42.96219.74YesYes1374
123A:A:F223 A:A:L249 42.43314.87YesNo099
124A:A:F196 A:A:V339 42.89445.24YesNo078
125A:A:I253 A:A:R208 42.42083.76NoYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7X9Y
Class A
SubFamily Protein
Type Chemokine
SubType CCR3
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.1
Date 2022-08-24
D.O.I. 10.1038/s41421-022-00403-4
Net Summary
Imin 2.66
Number of Linked Nodes 851
Number of Links 1020
Number of Hubs 167
Number of Links mediated by Hubs 592
Number of Communities 24
Number of Nodes involved in Communities 232
Number of Links involved in Communities 336
Path Summary
Number Of Nodes in MetaPath 126
Number Of Links MetaPath 125
Number of Shortest Paths 11761134
Length Of Smallest Path 3
Average Path Length 57.3653
Length of Longest Path 88
Minimum Path Strength 1.07
Average Path Strength 5.45428
Maximum Path Strength 21.045
Minimum Path Correlation 0.71
Average Path Correlation 0.996678
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5873
Average % Of Corr. Nodes 27.6074
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.98
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7X9Y_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKN 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLMNRMH ASMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7X9Y_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7X9Y_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP51677
Sequence
>7X9Y_Chain_R
ALMAQFVPP LYSLVFTVG LLGNVVVVM ILIKYRRLR IMTNIYLLN 
LAISDLLFL VTLPFWIHY VRGHNWVFG HGMCKLLSG FYHTGLYSE 
IFFIILLTI DRYLAIVHA VFALRARTV TFGVITSIV TWGLAVLAA 
LPEFIFYET EELFEETLC SALYPEDTV YSWRHFHTL RMTIFCLVL 
PLLVMAICY TGIIKTLLR CPSKKKYKA IRLIFVAMA VFFIFWTPY 
NVAILLSSY QSILFGNDC ERSKHLDLV MLVTEVIAY SHCCMNPVI 
YAFVGERFR KYLRHFFHR HLLMH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7X9YAProteinChemokineCCR3Homo sapiens--Gi1/&β;1/&γ;23.12022-08-2410.1038/s41421-022-00403-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7X9Y.zip



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