psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E180	R:R:M33	2.71	No	No	0	2	2
2	R:R:K277	R:R:Q35	2.71	No	No	0	3	4
3	R:R:F36	R:R:V94	3.93	No	No	0	5	4
4	R:R:F36	R:R:L284	4.87	No	No	0	5	5
5	R:R:P39	R:R:V37	7.07	No	No	0	5	6
6	R:R:L40	R:R:V37	7.45	No	No	0	5	6
7	R:R:P38	R:R:P39	5.84	No	No	0	6	5
8	R:R:P38	R:R:V94	7.07	No	No	0	6	4
9	R:R:V44	R:R:Y41	2.52	No	Yes	0	6	7
10	R:R:L87	R:R:Y41	5.86	No	Yes	2	7	7
11	R:R:I91	R:R:Y41	7.25	No	Yes	2	6	7
12	R:R:V288	R:R:Y41	6.31	No	Yes	0	4	7
13	R:R:S292	R:R:V44	4.85	No	No	0	5	6
14	R:R:C295	R:R:V44	3.42	No	No	0	7	6
15	R:R:F45	R:R:L49	9.74	No	No	0	6	6
16	R:R:F45	R:R:P88	10.11	No	No	0	6	9
17	R:R:L50	R:R:T46	2.95	No	No	0	4	5
18	R:R:C295	R:R:V47	3.42	No	No	0	7	6
19	R:R:L49	R:R:L84	4.15	No	Yes	0	6	6
20	R:R:D80	R:R:N52	6.73	Yes	No	0	9	9
21	R:R:L84	R:R:N52	5.49	Yes	No	0	6	9
22	R:R:N52	R:R:P298	8.15	No	No	0	9	9
23	R:R:F308	R:R:V55	2.62	Yes	No	0	8	8
24	R:R:L74	R:R:V56	4.47	No	No	0	5	7
25	R:R:F315	R:R:M57	8.71	No	No	0	4	4
26	R:R:F308	R:R:I58	3.77	Yes	Yes	5	8	8
27	R:R:I58	R:R:L312	2.85	Yes	No	5	8	6
28	R:R:F315	R:R:I58	5.02	No	Yes	0	4	8
29	R:R:L59	R:R:N70	4.12	No	Yes	0	6	8
30	R:R:L59	R:R:L73	5.54	No	No	0	6	8
31	R:R:I60	R:R:L65	4.28	No	No	0	3	6
32	R:R:K61	R:R:Y62	4.78	No	No	0	5	4
33	R:R:K61	R:R:R318	7.43	No	No	0	5	5
34	R:R:H314	R:R:Y62	3.27	No	No	0	4	4
35	R:R:F315	R:R:Y62	8.25	No	No	0	4	4
36	R:R:N70	R:R:R63	9.64	Yes	No	0	8	6
37	R:R:R63	R:R:Y311	18.52	No	No	0	6	4
38	R:R:I71	R:R:L65	2.85	No	No	0	5	6
39	R:R:L65	R:R:L74	6.92	No	No	0	6	5
40	R:R:R66	R:R:V147	2.62	No	No	0	7	3
41	R:R:I67	R:R:N70	9.91	No	Yes	0	7	8
42	R:R:M68	R:R:Y72	10.78	Yes	Yes	3	6	7
43	R:R:D130	R:R:M68	15.25	Yes	Yes	3	8	6
44	R:R:M68	R:R:R145	6.2	Yes	Yes	3	6	7
45	R:R:F149	R:R:M68	4.98	No	Yes	0	3	6
46	R:R:N70	R:R:T69	4.39	Yes	No	0	8	8
47	R:R:D130	R:R:T69	2.89	Yes	No	3	8	8
48	R:R:R145	R:R:T69	3.88	Yes	No	3	7	8
49	R:R:L126	R:R:Y72	9.38	No	Yes	0	5	7
50	R:R:L127	R:R:Y72	4.69	No	Yes	0	8	7
51	R:R:D130	R:R:Y72	8.05	Yes	Yes	3	8	7
52	R:R:T153	R:R:Y72	8.74	No	Yes	0	5	7
53	R:R:A302	R:R:L73	4.73	No	No	0	6	8
54	R:R:I78	R:R:L74	5.71	No	No	0	6	5
55	R:R:F123	R:R:N75	7.25	Yes	No	1	7	9
56	R:R:N75	R:R:S154	5.96	No	No	0	9	7
57	R:R:N75	R:R:W158	3.39	No	Yes	1	9	9
58	R:R:D80	R:R:L76	4.07	Yes	Yes	1	9	9
59	R:R:F123	R:R:L76	7.31	Yes	Yes	1	7	9
60	R:R:I124	R:R:L76	5.71	No	Yes	1	8	9
61	R:R:L76	R:R:N297	6.87	Yes	Yes	1	9	9
62	R:R:S119	R:R:S79	6.52	Yes	No	1	7	8
63	R:R:F123	R:R:S79	2.64	Yes	No	1	7	8
64	R:R:S79	R:R:W158	3.71	No	Yes	1	8	9
65	R:R:D80	R:R:E120	5.2	Yes	No	0	9	9
66	R:R:C294	R:R:D80	6.22	No	Yes	0	9	9
67	R:R:D80	R:R:N297	5.39	Yes	Yes	1	9	9
68	R:R:L81	R:R:V85	2.98	No	No	0	7	5
69	R:R:F112	R:R:L82	9.74	Yes	No	0	4	7
70	R:R:F83	R:R:Y113	7.22	No	Yes	2	7	6
71	R:R:F83	R:R:L117	12.18	No	No	0	7	7
72	R:R:F83	R:R:Y291	11.35	No	No	2	7	7
73	R:R:C294	R:R:L84	3.17	No	Yes	0	9	6
74	R:R:F112	R:R:T86	3.89	Yes	No	0	4	6
75	R:R:T86	R:R:Y113	3.75	No	Yes	0	6	6
76	R:R:I91	R:R:L87	2.85	No	No	2	6	7
77	R:R:L87	R:R:Y113	4.69	No	Yes	2	7	6
78	R:R:F89	R:R:L109	3.65	No	No	0	6	5
79	R:R:W90	R:R:Y113	8.68	No	Yes	0	6	6
80	R:R:H92	R:R:H97	7.17	No	No	0	3	5
81	R:R:N98	R:R:Y93	5.81	No	No	0	5	4
82	R:R:W99	R:R:Y93	21.22	Yes	No	0	9	4
83	R:R:L182	R:R:Y93	8.21	No	No	0	2	4
84	R:R:H97	R:R:R95	4.51	No	No	0	5	3
85	R:R:E180	R:R:N98	7.89	No	No	0	2	5
86	R:R:N98	R:R:T181	2.92	No	No	0	5	4
87	R:R:C106	R:R:W99	2.61	No	Yes	6	9	9
88	R:R:L109	R:R:W99	7.97	No	Yes	0	5	9
89	R:R:T181	R:R:W99	3.64	No	Yes	0	4	9
90	R:R:C183	R:R:W99	9.14	No	Yes	6	9	9
91	R:R:F101	R:R:G102	3.01	No	No	0	7	8
92	R:R:F101	R:R:G104	3.01	No	No	0	7	1
93	R:R:G102	R:R:H103	4.77	No	No	0	8	3
94	R:R:C106	R:R:T174	3.38	No	No	0	9	4
95	R:R:C106	R:R:C183	7.28	No	No	6	9	9
96	R:R:F171	R:R:S110	9.25	No	No	0	4	5
97	R:R:C183	R:R:S110	3.44	No	No	0	9	5
98	R:R:F169	R:R:G111	6.02	No	No	0	5	6
99	R:R:F112	R:R:F169	4.29	Yes	No	0	4	5
100	R:R:Y113	R:R:Y291	5.96	Yes	No	2	6	7
101	R:R:E168	R:R:H114	29.54	No	No	7	5	4
102	R:R:H114	R:R:M203	2.63	No	Yes	7	4	5
103	R:R:A165	R:R:T115	3.36	No	No	0	7	5
104	R:R:F169	R:R:T115	2.59	No	No	0	5	5
105	R:R:G116	R:R:S119	3.71	No	Yes	0	8	7
106	R:R:E120	R:R:L117	6.63	No	No	0	9	7
107	R:R:A164	R:R:Y118	2.67	No	Yes	0	5	7
108	R:R:C207	R:R:Y118	2.69	Yes	Yes	0	6	7
109	R:R:S119	R:R:W158	6.18	Yes	Yes	1	7	9
110	R:R:E120	R:R:W252	5.45	No	Yes	0	9	9
111	R:R:I121	R:R:I125	2.94	Yes	No	1	8	7
112	R:R:C207	R:R:I121	3.27	Yes	Yes	1	6	8
113	R:R:I121	R:R:P211	3.39	Yes	Yes	1	8	9
114	R:R:I121	R:R:W252	8.22	Yes	Yes	1	8	9
115	R:R:F123	R:R:T157	6.49	Yes	No	0	7	7
116	R:R:F123	R:R:W158	14.03	Yes	Yes	1	7	9
117	R:R:I124	R:R:N297	5.66	No	Yes	1	8	9
118	R:R:I124	R:R:Y301	8.46	No	Yes	0	8	9
119	R:R:I125	R:R:P211	3.39	No	Yes	1	7	9
120	R:R:I125	R:R:V214	3.07	No	No	0	7	6
121	R:R:L126	R:R:T157	5.9	No	No	0	5	7
122	R:R:L127	R:R:Y301	8.21	No	Yes	0	8	9
123	R:R:M215	R:R:T128	4.52	Yes	No	1	8	9
124	R:R:C218	R:R:T128	3.38	No	No	0	6	9
125	R:R:T128	R:R:Y219	7.49	No	Yes	1	9	9
126	R:R:I129	R:R:V214	3.07	No	No	0	6	6
127	R:R:C218	R:R:I129	3.27	No	No	0	6	6
128	R:R:D130	R:R:R145	10.72	Yes	Yes	3	8	7
129	R:R:R131	R:R:Y301	8.23	No	Yes	0	9	9
130	R:R:V136	R:R:Y132	11.36	No	No	0	6	8
131	R:R:C218	R:R:Y132	6.72	No	No	0	6	8
132	R:R:I222	R:R:Y132	4.84	No	No	0	8	8
133	R:R:H137	R:R:L133	2.57	No	No	0	6	5
134	R:R:F140	R:R:L133	6.09	No	No	0	5	5
135	R:R:A134	R:R:R145	4.15	No	Yes	0	8	7
136	R:R:I135	R:R:I222	13.25	No	No	8	8	8
137	R:R:I135	R:R:T225	3.04	No	No	0	8	6
138	R:R:I135	R:R:L226	4.28	No	Yes	8	8	8
139	R:R:H137	R:R:V136	13.84	No	No	0	6	6
140	R:R:T225	R:R:V136	3.17	No	No	0	6	6
141	R:R:A144	R:R:F140	6.93	No	No	0	4	5
142	R:R:T146	R:R:T148	3.14	No	No	0	6	4
143	R:R:F149	R:R:T146	3.89	No	No	0	3	6
144	R:R:F149	R:R:T153	7.78	No	No	0	3	5
145	R:R:S154	R:R:V151	3.23	No	No	0	7	3
146	R:R:I155	R:R:V151	3.07	No	No	0	3	3
147	R:R:L166	R:R:P167	3.28	No	No	0	4	8
148	R:R:E168	R:R:M203	2.71	No	Yes	7	5	5
149	R:R:I170	R:R:Y172	14.51	No	No	0	4	5
150	R:R:E173	R:R:S184	2.87	No	No	0	4	3
151	R:R:E176	R:R:T174	4.23	No	No	0	2	4
152	R:R:E175	R:R:L182	3.98	No	No	0	2	2
153	R:R:E175	R:R:S184	7.19	No	No	0	2	3
154	R:R:E176	R:R:T181	2.82	No	No	0	2	4
155	R:R:H199	R:R:L186	9	No	No	0	5	3
156	R:R:P188	R:R:Y187	9.74	No	Yes	0	6	5
157	R:R:T191	R:R:Y187	4.99	Yes	Yes	4	3	5
158	R:R:S194	R:R:Y187	5.09	No	Yes	4	1	5
159	R:R:W195	R:R:Y187	13.5	Yes	Yes	4	2	5
160	R:R:T191	R:R:Y193	4.99	Yes	No	0	3	3
161	R:R:S194	R:R:T191	3.2	No	Yes	4	1	3
162	R:R:R196	R:R:Y193	3.09	No	No	0	3	3
163	R:R:S194	R:R:W195	6.18	No	Yes	4	1	2
164	R:R:F198	R:R:W195	4.01	No	Yes	0	3	2
165	R:R:H197	R:R:L201	9	No	No	0	3	4
166	R:R:H197	R:R:R202	6.77	No	No	0	3	4
167	R:R:F198	R:R:R202	16.03	No	No	0	3	4
168	R:R:H199	R:R:M203	10.51	No	Yes	0	5	5
169	R:R:L201	R:R:T200	4.42	No	No	0	4	5
170	R:R:T200	R:R:Y264	13.73	No	No	0	5	3
171	R:R:C207	R:R:W252	3.92	Yes	Yes	1	6	9
172	R:R:C207	R:R:N256	4.72	Yes	No	1	6	7
173	R:R:L208	R:R:T253	4.42	No	No	0	8	5
174	R:R:L208	R:R:N256	17.85	No	No	0	8	7
175	R:R:L210	R:R:P211	4.93	No	Yes	0	5	9
176	R:R:L210	R:R:V214	2.98	No	No	0	5	6
177	R:R:F248	R:R:P211	2.89	Yes	Yes	1	9	9
178	R:R:F249	R:R:L212	4.87	No	No	0	5	6
179	R:R:M215	R:R:Y219	13.17	Yes	Yes	1	8	9
180	R:R:M215	R:R:M245	2.89	Yes	No	1	8	7
181	R:R:F248	R:R:M215	4.98	Yes	Yes	1	9	8
182	R:R:I241	R:R:Y219	8.46	No	Yes	0	7	9
183	R:R:M245	R:R:Y219	9.58	No	Yes	1	7	9
184	R:R:G221	R:R:T220	3.64	No	No	0	4	3
185	R:R:I222	R:R:L226	2.85	No	Yes	8	8	8
186	R:R:I223	R:R:I238	10.3	No	No	0	4	5
187	R:R:I223	R:R:I241	4.42	No	No	0	4	7
188	R:R:I238	R:R:L226	2.85	No	Yes	0	5	8
189	R:R:E306	R:R:K233	4.05	No	No	0	5	5
190	R:R:K234	R:R:Y235	8.36	No	No	0	7	5
191	R:R:L240	R:R:V304	7.45	No	No	0	7	5
192	R:R:M296	R:R:V247	3.04	No	No	0	5	6
193	R:R:F248	R:R:W252	11.02	Yes	Yes	1	9	9
194	R:R:F248	R:R:H293	5.66	Yes	No	1	9	9
195	R:R:F249	R:R:T253	14.27	No	No	0	5	5
196	R:R:F251	R:R:I250	5.02	No	No	0	7	5
197	R:R:F251	R:R:I289	8.79	No	No	0	7	7
198	R:R:F251	R:R:M296	6.22	No	No	0	7	5
199	R:R:W252	R:R:Y255	4.82	Yes	Yes	0	9	7
200	R:R:N256	R:R:W252	9.04	No	Yes	1	7	9
201	R:R:H293	R:R:W252	8.46	No	Yes	1	9	9
202	R:R:P254	R:R:T253	3.5	No	No	0	9	5
203	R:R:A290	R:R:Y255	2.67	No	Yes	0	8	7
204	R:R:L261	R:R:V257	2.98	No	No	0	5	5
205	R:R:A258	R:R:T286	3.36	No	No	0	4	6
206	R:R:I259	R:R:S262	3.1	No	No	0	6	4
207	R:R:L261	R:R:Q265	9.32	No	Yes	0	5	4
208	R:R:L279	R:R:S262	3	No	No	0	4	4
209	R:R:S263	R:R:Y264	6.36	No	No	0	5	3
210	R:R:F269	R:R:R275	8.55	No	No	0	4	1
211	R:R:E274	R:R:H278	9.85	No	No	0	3	2
212	R:R:D280	R:R:S276	2.94	No	No	0	3	4
213	R:R:L284	R:R:M283	2.83	No	No	0	5	5
214	R:R:E287	R:R:M283	8.12	No	No	0	6	5
215	R:R:I289	R:R:V285	3.07	No	No	0	7	5
216	R:R:H293	R:R:N297	16.58	No	Yes	1	9	9
217	R:R:F303	R:R:V299	10.49	No	No	0	6	5
218	R:R:I300	R:R:Y301	3.63	No	Yes	0	7	9
219	R:R:A302	R:R:F308	5.55	No	Yes	0	6	8
220	R:R:F303	R:R:F308	7.5	No	Yes	0	6	8
221	R:R:R307	R:R:Y311	6.17	No	No	0	7	4
222	R:R:F308	R:R:L312	3.65	Yes	No	5	8	6
223	R:R:H317	R:R:R313	5.64	No	No	0	4	5
224	R:R:F316	R:R:L320	9.74	No	No	0	5	2
225	R:R:M322	R:R:R318	11.17	No	No	0	4	5
226	R:R:H319	R:R:H323	13.14	No	No	0	3	5
227	R:R:F242	R:R:I238	2.51	No	No	0	5	5
228	R:R:F112	R:R:L108	2.44	Yes	No	0	4	4
229	R:R:M203	R:R:Y118	2.39	Yes	Yes	0	5	7
230	R:R:D272	R:R:R275	2.38	No	No	0	5	1
231	R:R:I170	R:R:W195	2.35	No	Yes	0	4	2
232	R:R:F269	R:R:Q265	2.34	No	Yes	0	4	4
233	R:R:E168	R:R:F171	2.33	No	No	0	5	4
234	R:R:L186	R:R:W195	2.28	No	Yes	0	3	2
235	R:R:E287	R:R:Y255	2.24	No	Yes	0	6	7
236	R:R:F206	R:R:R202	2.14	No	No	0	5	4
237	R:R:F122	R:R:Y118	2.06	No	Yes	0	5	7
238	R:R:C295	R:R:G48	1.96	No	No	0	7	8
239	R:R:C229	R:R:P230	1.88	No	No	0	4	4
240	R:R:G150	R:R:T153	1.82	No	No	0	7	5
241	R:R:A134	R:R:A141	1.79	No	No	0	8	6
242	R:R:G150	R:R:I71	1.76	No	No	0	7	5
243	R:R:P254	R:R:T286	1.75	No	No	0	9	6
244	R:R:A161	R:R:S119	1.71	No	Yes	0	7	7
245	R:R:A77	R:R:V55	1.7	No	No	0	8	8
246	R:R:A77	R:R:V56	1.7	No	No	0	8	7
247	R:R:G270	R:R:Q265	1.64	No	Yes	0	1	4
248	R:R:C229	R:R:K234	1.62	No	No	0	4	7
249	R:R:A244	R:R:I300	1.62	No	No	0	7	7
250	R:R:A246	R:R:I250	1.62	No	No	0	4	5
251	R:R:A216	R:R:M245	1.61	No	No	0	4	7
252	R:R:V147	R:R:V151	1.6	No	No	0	3	3
253	R:R:V243	R:R:V247	1.6	No	No	0	5	6
254	R:R:T115	R:R:V162	1.59	No	No	0	5	3
255	R:R:C229	R:R:L226	1.59	No	Yes	0	4	8
256	R:R:T286	R:R:V282	1.59	No	No	0	6	5
257	R:R:A185	R:R:L186	1.58	No	No	0	5	3
258	R:R:A237	R:R:L226	1.58	No	Yes	0	7	8
259	R:R:I267	R:R:S266	1.55	No	No	0	3	3
260	R:R:I58	R:R:V54	1.54	Yes	No	0	8	6
261	R:R:I152	R:R:V156	1.54	No	No	0	2	4
262	R:R:I300	R:R:V243	1.54	No	No	0	7	5
263	R:R:A34	R:R:Q35	1.52	No	No	0	5	4
264	R:R:I205	R:R:T204	1.52	No	No	0	5	5
265	R:R:K224	R:R:T220	1.5	No	No	0	4	3
266	R:R:L279	R:R:S266	1.5	No	No	0	4	3
267	R:R:L49	R:R:V53	1.49	No	No	0	6	4
268	R:R:L81	R:R:V53	1.49	No	No	0	7	4
269	R:R:L84	R:R:V85	1.49	Yes	No	0	6	5
270	R:R:L43	R:R:T46	1.47	No	No	0	5	5
271	R:R:D190	R:R:T191	1.45	No	Yes	0	3	3
272	R:R:I170	R:R:L166	1.43	No	No	0	4	4
273	R:R:I205	R:R:L201	1.43	No	No	0	5	4
274	R:R:I217	R:R:L213	1.43	No	No	0	4	3
275	R:R:I223	R:R:L227	1.43	No	No	0	4	5
276	R:R:G159	R:R:W158	1.41	No	Yes	0	4	9
277	R:R:K236	R:R:L240	1.41	No	No	0	7	7
278	R:R:L279	R:R:Q265	1.33	No	Yes	0	4	4
279	R:R:D272	R:R:E274	1.3	No	No	0	5	3
280	R:R:F178	R:R:L177	1.22	No	No	0	1	1
281	R:R:I259	R:R:Y255	1.21	No	Yes	0	6	7
282	R:R:E180	R:R:F178	1.17	No	No	0	2	1
283	R:R:E306	R:R:R309	1.16	No	No	0	5	8
284	R:R:F316	R:R:H317	1.13	No	No	0	5	4
285	R:R:R64	R:R:R66	1.07	No	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y41	5.485	4	2	7
2	R:R:I58	3.295	4	5	8
3	R:R:M68	9.3025	4	3	6
4	R:R:N70	7.015	4	0	8
5	R:R:Y72	8.328	5	3	7
6	R:R:L76	5.99	4	1	9
7	R:R:D80	5.522	5	1	9
8	R:R:L84	3.575	4	0	6
9	R:R:W99	8.916	5	6	9
10	R:R:F112	5.09	4	0	4
11	R:R:Y113	6.06	5	2	6
12	R:R:Y118	2.4525	4	0	7
13	R:R:S119	4.53	4	1	7
14	R:R:I121	4.455	4	1	8
15	R:R:F123	7.544	5	1	7
16	R:R:D130	9.2275	4	3	8
17	R:R:R145	6.2375	4	3	7
18	R:R:W158	5.744	5	1	9
19	R:R:Y187	8.33	4	4	5
20	R:R:T191	3.6575	4	4	3
21	R:R:W195	5.664	5	4	2
22	R:R:M203	4.56	4	7	5
23	R:R:C207	3.65	4	1	6
24	R:R:P211	3.65	4	1	9
25	R:R:M215	6.39	4	1	8
26	R:R:Y219	9.675	4	1	9
27	R:R:L226	2.63	5	8	8
28	R:R:F248	6.1375	4	1	9
29	R:R:W252	7.27571	7	1	9
30	R:R:Y255	2.735	4	0	7
31	R:R:Q265	3.6575	4	0	4
32	R:R:N297	8.625	4	1	9
33	R:R:Y301	7.1325	4	0	9
34	R:R:F308	4.618	5	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E180	R:R:N98	15.5205	7.89	No	No	0	2	5
2	R:R:W99	R:R:Y93	19.3797	21.22	Yes	No	0	9	4
3	R:R:C183	R:R:W99	38.0015	9.14	No	Yes	6	9	9
4	R:R:C183	R:R:S110	45.3793	3.44	No	No	0	9	5
5	R:R:F171	R:R:S110	47.1316	9.25	No	No	0	4	5
6	R:R:E168	R:R:F171	48.8492	2.33	No	No	0	5	4
7	R:R:E168	R:R:M203	50.2608	2.71	No	Yes	7	5	5
8	R:R:M203	R:R:Y118	96.2172	2.39	Yes	Yes	0	5	7
9	R:R:C207	R:R:Y118	100	2.69	Yes	Yes	0	6	7
10	R:R:C207	R:R:W252	87.8937	3.92	Yes	Yes	1	6	9
11	R:R:W252	R:R:Y255	44.8091	4.82	Yes	Yes	0	9	7
12	R:R:E287	R:R:Y255	17.092	2.24	No	Yes	0	6	7
13	R:R:E287	R:R:M283	15.2354	8.12	No	No	0	6	5
14	R:R:L284	R:R:M283	13.3649	2.83	No	No	0	5	5
15	R:R:F36	R:R:L284	11.4804	4.87	No	No	0	5	5
16	R:R:T181	R:R:W99	13.5109	3.64	No	Yes	0	4	9
17	R:R:E120	R:R:W252	54.4399	5.45	No	Yes	0	9	9
18	R:R:E120	R:R:L117	55.8376	6.63	No	No	0	9	7
19	R:R:F83	R:R:L117	53.5498	12.18	No	No	0	7	7
20	R:R:F83	R:R:Y113	48.7935	7.22	No	Yes	2	7	6
21	R:R:L87	R:R:Y113	22.7244	4.69	No	Yes	2	7	6
22	R:R:L87	R:R:Y41	17.697	5.86	No	Yes	2	7	7
23	R:R:V44	R:R:Y41	12.8225	2.52	No	Yes	0	6	7
24	R:R:D80	R:R:E120	66.3028	5.2	Yes	No	0	9	9
25	R:R:D80	R:R:N52	24.5393	6.73	Yes	No	0	9	9
26	R:R:L84	R:R:N52	19.185	5.49	Yes	No	0	6	9
27	R:R:L49	R:R:L84	21.9317	4.15	No	Yes	0	6	6
28	R:R:F45	R:R:L49	11.0076	9.74	No	No	0	6	6
29	R:R:C294	R:R:D80	21.8135	6.22	No	Yes	0	9	9
30	R:R:C294	R:R:L84	19.1364	3.17	No	Yes	0	9	6
31	R:R:H293	R:R:W252	58.8207	8.46	No	Yes	1	9	9
32	R:R:H293	R:R:N297	86.6351	16.58	No	Yes	1	9	9
33	R:R:I124	R:R:N297	79.7024	5.66	No	Yes	1	8	9
34	R:R:I124	R:R:Y301	98.5884	8.46	No	Yes	0	8	9
35	R:R:L127	R:R:Y301	82.3587	8.21	No	Yes	0	8	9
36	R:R:L127	R:R:Y72	81.0514	4.69	No	Yes	0	8	7
37	R:R:D130	R:R:Y72	57.8541	8.05	Yes	Yes	3	8	7
38	R:R:D130	R:R:T69	49.8783	2.89	Yes	No	3	8	8
39	R:R:N70	R:R:T69	48.8979	4.39	Yes	No	0	8	8
40	R:R:L59	R:R:N70	38.4466	4.12	No	Yes	0	6	8
41	R:R:L59	R:R:L73	36.3118	5.54	No	No	0	6	8
42	R:R:A302	R:R:L73	34.184	4.73	No	No	0	6	8
43	R:R:A302	R:R:F308	32.0562	5.55	No	Yes	0	6	8
44	R:R:T153	R:R:Y72	28.5724	8.74	No	Yes	0	5	7
45	R:R:G150	R:R:T153	20.395	1.82	No	No	0	7	5
46	R:R:G150	R:R:I71	18.2463	1.76	No	No	0	7	5
47	R:R:I71	R:R:L65	16.0976	2.85	No	No	0	5	6
48	R:R:L65	R:R:L74	11.7864	6.92	No	No	0	6	5
49	R:R:F308	R:R:I58	21.1738	3.77	Yes	Yes	5	8	8
50	R:R:F315	R:R:I58	16.5635	5.02	No	Yes	0	4	8
51	R:R:F315	R:R:Y62	11.995	8.25	No	No	0	4	4
52	R:R:D80	R:R:L76	51.867	4.07	Yes	Yes	1	9	9
53	R:R:F123	R:R:L76	54.0922	7.31	Yes	Yes	1	7	9
54	R:R:F123	R:R:N75	17.2728	7.25	Yes	No	1	7	9
55	R:R:N75	R:R:S154	15.0963	5.96	No	No	0	9	7
56	R:R:S154	R:R:V151	12.6139	3.23	No	No	0	7	3
57	R:R:L76	R:R:N297	20.0195	6.87	Yes	Yes	1	9	9
58	R:R:M68	R:R:Y72	14.9781	10.78	Yes	Yes	3	6	7
59	R:R:F123	R:R:T157	24.4211	6.49	Yes	No	0	7	7
60	R:R:L126	R:R:T157	22.641	5.9	No	No	0	5	7
61	R:R:F123	R:R:W158	12.301	14.03	Yes	Yes	1	7	9
62	R:R:L84	R:R:V85	10.9728	1.49	Yes	No	0	6	5
63	R:R:T86	R:R:Y113	22.8357	3.75	No	Yes	0	6	6
64	R:R:F112	R:R:T86	20.3532	3.89	Yes	No	0	4	6
65	R:R:F112	R:R:F169	12.8225	4.29	Yes	No	0	4	5
66	R:R:I121	R:R:I125	12.2384	2.94	Yes	No	1	8	7
67	R:R:I125	R:R:V214	11.9602	3.07	No	No	0	7	6
68	R:R:F248	R:R:W252	32.8489	11.02	Yes	Yes	1	9	9
69	R:R:F248	R:R:M215	54.7111	4.98	Yes	Yes	1	9	8
70	R:R:M215	R:R:T128	29.5529	4.52	Yes	No	1	8	9
71	R:R:C218	R:R:T128	28.3082	3.38	No	No	0	6	9
72	R:R:I129	R:R:V214	10.6182	3.07	No	No	0	6	6
73	R:R:M215	R:R:Y219	20.4158	13.17	Yes	Yes	1	8	9
74	R:R:C218	R:R:Y132	33.134	6.72	No	No	0	6	8
75	R:R:V136	R:R:Y132	13.8029	11.36	No	No	0	6	8
76	R:R:I222	R:R:Y132	17.9821	4.84	No	No	0	8	8
77	R:R:I222	R:R:L226	13.5596	2.85	No	Yes	8	8	8
78	R:R:I241	R:R:Y219	19.0668	8.46	No	Yes	0	7	9
79	R:R:I223	R:R:I241	17.4536	4.42	No	No	0	4	7
80	R:R:I223	R:R:I238	14.2062	10.3	No	No	0	4	5
81	R:R:I238	R:R:L226	11.0006	2.85	No	Yes	0	5	8
82	R:R:H199	R:R:M203	54.0088	10.51	No	Yes	0	5	5
83	R:R:H199	R:R:L186	52.326	9	No	No	0	5	3
84	R:R:L186	R:R:W195	49.023	2.28	No	Yes	0	3	2
85	R:R:W195	R:R:Y187	11.9463	13.5	Yes	Yes	4	2	5
86	R:R:F198	R:R:W195	19.8804	4.01	No	Yes	0	3	2
87	R:R:F198	R:R:R202	17.9403	16.03	No	No	0	3	4
88	R:R:H197	R:R:R202	14.0185	6.77	No	No	0	3	4
89	R:R:H197	R:R:L201	12.0367	9	No	No	0	3	4
90	R:R:L208	R:R:N256	15.6804	17.85	No	No	0	8	7
91	R:R:L208	R:R:T253	13.7682	4.42	No	No	0	8	5
92	R:R:C229	R:R:L226	16.2089	1.59	No	Yes	0	4	8
93	R:R:I300	R:R:Y301	20.6592	3.63	No	Yes	0	7	9
94	R:R:I300	R:R:V243	16.7026	1.54	No	No	0	7	5
95	R:R:V243	R:R:V247	14.7903	1.6	No	No	0	5	6
96	R:R:M296	R:R:V247	12.7182	3.04	No	No	0	5	6
97	R:R:F251	R:R:M296	10.6321	6.22	No	No	0	7	5
98	R:R:I259	R:R:Y255	26.1804	1.21	No	Yes	0	6	7
99	R:R:I259	R:R:S262	24.3933	3.1	No	No	0	6	4
100	R:R:L279	R:R:S262	22.5784	3	No	No	0	4	4
101	R:R:L279	R:R:Q265	17.1824	1.33	No	Yes	0	4	4
102	R:R:N256	R:R:W252	13.3231	9.04	No	Yes	1	7	9
103	R:R:L126	R:R:Y72	20.9373	9.38	No	Yes	0	5	7
104	R:R:I124	R:R:L76	20.2003	5.71	No	Yes	1	8	9
105	R:R:D80	R:R:N297	22.8148	5.39	Yes	Yes	1	9	9
106	R:R:F248	R:R:H293	28.2595	5.66	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7X9Y_nogp

PDB Summary
PDB	7X9Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.52
Number of Linked Nodes	263
Number of Links	285
Number of Hubs	34
Number of Links mediated by Hubs	123
Number of Communities	8
Number of Nodes involved in Communities	48
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	107
Number Of Links MetaPath	106
Number of Shortest Paths	42352
Length Of Smallest Path	3
Average Path Length	14.1756
Length of Longest Path	33
Minimum Path Strength	1.195
Average Path Strength	5.94342
Maximum Path Strength	15.935
Minimum Path Correlation	0.7
Average Path Correlation	0.934618
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	52.9241
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.3499
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • chemokine binding • cytokine binding • chemotaxis • taxis • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell chemotaxis • cell migration • cell motility • immune response • immune system process • regulation of developmental process • positive regulation of biological process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • positive regulation of multicellular organismal process • cell adhesion • defense response • response to stress • cellular defense response • inflammatory response • positive regulation of cell population proliferation • endothelial cell proliferation • positive regulation of epithelial cell proliferation • regulation of endothelial cell proliferation • regulation of cell population proliferation • positive regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • positive regulation of cellular process • calcium-mediated signaling • cell surface • external side of plasma membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51677
Sequence	>7X9Y_nogp_Chain_R A L M A Q F V P P L Y S L V F T V G L L G N V V V V M I L I K Y R R L R I M T N I Y L L N L A I S D L L F L V T L P F W I H Y V R G H N W V F G H G M C K L L S G F Y H T G L Y S E I F F I I L L T I D R Y L A I V H A V F A L R A R T V T F G V I T S I V T W G L A V L A A L P E F I F Y E T E E L F E E T L C S A L Y P E D T V Y S W R H F H T L R M T I F C L V L P L L V M A I C Y T G I I K T L L R C P S K K K Y K A I R L I F V A M A V F F I F W T P Y N V A I L L S S Y Q S I L F G N D C E R S K H L D L V M L V T E V I A Y S H C C M N P V I Y A F V G E R F R K Y L R H F F H R H L L M H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X9Y	A	Protein	Chemokine	CCR3	Homo sapiens	-	-	Gi1/β1/γ2	3.1	2022-08-24	10.1038/s41421-022-00403-4
	7X9Y (No Gprot)	A	Protein	Chemokine	CCR3	Homo sapiens	-	-		3.1	2022-08-24	10.1038/s41421-022-00403-4

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