psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I50	R:R:M47	8.75	No	No	4	6	4
2	R:R:H294	R:R:M47	9.19	Yes	No	4	3	4
3	R:R:I50	R:R:Y54	6.04	No	Yes	4	6	6
4	R:R:H294	R:R:I50	3.98	Yes	No	4	3	6
5	R:R:I298	R:R:I53	13.25	Yes	No	0	5	5
6	R:R:A104	R:R:Y54	4	No	Yes	0	6	6
7	R:R:H294	R:R:Y54	3.27	Yes	Yes	4	3	6
8	R:R:I298	R:R:Y54	4.84	Yes	Yes	0	5	6
9	R:R:I298	R:R:V57	3.07	Yes	No	0	5	7
10	R:R:A302	R:R:V57	3.39	No	No	0	6	7
11	R:R:C305	R:R:V57	5.12	No	No	0	7	7
12	R:R:C58	R:R:V100	3.42	No	Yes	0	6	7
13	R:R:C305	R:R:G61	3.92	No	No	0	7	8
14	R:R:E94	R:R:L62	5.3	No	No	0	7	6
15	R:R:D93	R:R:N65	10.77	No	No	5	9	9
16	R:R:E94	R:R:N65	7.89	No	No	0	7	9
17	R:R:N65	R:R:P308	13.03	No	No	5	9	9
18	R:R:I72	R:R:V68	3.07	No	No	0	7	8
19	R:R:F318	R:R:V71	3.93	Yes	No	0	8	8
20	R:R:I72	R:R:L87	7.14	No	No	0	7	6
21	R:R:F318	R:R:I72	8.79	Yes	No	0	8	7
22	R:R:A76	R:R:K79	3.21	No	No	2	5	6
23	R:R:A76	R:R:N83	6.25	No	Yes	2	5	8
24	R:R:I84	R:R:M78	5.83	Yes	No	0	5	7
25	R:R:K79	R:R:N83	9.79	No	Yes	2	6	8
26	R:R:K79	R:R:R320	3.71	No	No	0	6	4
27	R:R:T80	R:R:T82	3.14	No	No	2	8	8
28	R:R:R158	R:R:T80	7.76	Yes	No	2	6	8
29	R:R:A81	R:R:Y85	5.34	No	Yes	2	5	7
30	R:R:A81	R:R:D143	3.09	No	No	2	5	8
31	R:R:R158	R:R:T82	6.47	Yes	No	2	6	8
32	R:R:F318	R:R:N83	3.62	Yes	Yes	0	8	8
33	R:R:A163	R:R:I84	4.87	No	Yes	0	7	5
34	R:R:L140	R:R:Y85	10.55	No	Yes	0	9	7
35	R:R:D143	R:R:Y85	10.34	No	Yes	2	8	7
36	R:R:I166	R:R:Y85	3.63	No	Yes	0	6	7
37	R:R:F318	R:R:L86	13.4	Yes	No	0	8	8
38	R:R:C136	R:R:N88	7.87	No	No	0	7	9
39	R:R:N167	R:R:N88	13.62	No	No	0	7	9
40	R:R:N88	R:R:W171	5.65	No	Yes	0	9	9
41	R:R:C136	R:R:L89	4.76	No	No	0	7	9
42	R:R:D93	R:R:S304	5.89	No	No	0	9	9
43	R:R:D93	R:R:P308	3.22	No	No	5	9	9
44	R:R:L95	R:R:N129	8.24	No	No	0	7	8
45	R:R:D126	R:R:F96	4.78	Yes	No	1	6	7
46	R:R:F96	R:R:Y301	17.54	No	Yes	1	7	6
47	R:R:M97	R:R:V100	3.04	No	Yes	0	7	7
48	R:R:C305	R:R:M97	4.86	No	No	0	7	7
49	R:R:S99	R:R:V122	3.23	No	No	0	6	5
50	R:R:D126	R:R:S99	10.31	Yes	No	0	6	6
51	R:R:P101	R:R:V100	5.3	No	Yes	0	8	7
52	R:R:V100	R:R:Y301	5.05	Yes	Yes	0	7	6
53	R:R:F102	R:R:W112	4.01	No	Yes	1	5	8
54	R:R:F102	R:R:F114	4.29	No	Yes	1	5	6
55	R:R:V103	R:R:Y301	6.31	No	Yes	0	5	6
56	L:L:?1	R:R:V103	13.93	Yes	No	0	0	5
57	R:R:S106	R:R:W112	7.41	No	Yes	0	4	8
58	R:R:L109	R:R:P113	3.28	No	No	0	4	3
59	R:R:H111	R:R:P113	3.05	No	No	0	5	3
60	R:R:F114	R:R:W112	20.04	Yes	Yes	1	6	8
61	R:R:C119	R:R:W112	15.67	No	Yes	1	9	8
62	R:R:C198	R:R:W112	3.92	No	Yes	1	9	8
63	L:L:?1	R:R:W112	5.32	Yes	Yes	1	0	8
64	R:R:R120	R:R:S116	5.27	No	No	0	6	2
65	R:R:S116	R:R:T187	7.99	No	No	0	2	5
66	R:R:C119	R:R:C198	7.28	No	No	1	9	9
67	L:L:?1	R:R:L123	7.55	Yes	No	0	0	4
68	R:R:I181	R:R:S124	3.1	No	No	0	4	6
69	R:R:N129	R:R:V125	4.43	No	No	0	8	5
70	R:R:D126	R:R:Y301	4.6	Yes	Yes	1	6	6
71	L:L:?1	R:R:D126	16.92	Yes	Yes	1	0	6
72	R:R:G127	R:R:M130	3.49	No	Yes	0	5	7
73	R:R:L128	R:R:W171	6.83	Yes	Yes	0	6	9
74	R:R:L128	R:R:S174	4.5	Yes	Yes	0	6	8
75	R:R:L128	R:R:L175	6.92	Yes	No	0	6	3
76	R:R:L128	R:R:T178	5.9	Yes	No	0	6	7
77	R:R:F131	R:R:M130	4.98	Yes	Yes	1	6	7
78	R:R:M130	R:R:W272	5.82	Yes	Yes	0	7	8
79	L:L:?1	R:R:M130	6.61	Yes	Yes	1	0	7
80	R:R:F131	R:R:S174	5.28	Yes	Yes	0	6	8
81	R:R:F131	R:R:V177	9.18	Yes	No	0	6	5
82	R:R:F131	R:R:T178	6.49	Yes	No	0	6	7
83	R:R:F131	R:R:T215	3.89	Yes	No	1	6	5
84	L:L:?1	R:R:F131	6.64	Yes	Yes	1	0	6
85	R:R:T132	R:R:W171	19.41	No	Yes	0	7	9
86	R:R:S174	R:R:T132	3.2	Yes	No	0	8	7
87	R:R:P223	R:R:V134	3.53	No	No	0	8	8
88	R:R:F268	R:R:V134	3.93	No	No	0	9	8
89	R:R:F135	R:R:S174	3.96	No	Yes	0	6	8
90	R:R:F135	R:R:V177	3.93	No	No	0	6	5
91	R:R:L137	R:R:Y311	7.03	No	Yes	0	8	9
92	R:R:V139	R:R:V170	3.21	No	No	0	7	7
93	R:R:L140	R:R:R144	13.36	No	No	0	9	9
94	R:R:I227	R:R:S141	7.74	No	No	3	8	9
95	R:R:C230	R:R:S141	3.44	No	No	0	7	9
96	R:R:S141	R:R:Y231	7.63	No	Yes	3	9	9
97	R:R:C230	R:R:V142	3.42	No	No	0	7	6
98	R:R:D143	R:R:R158	7.15	No	Yes	2	8	6
99	R:R:R144	R:R:Y231	7.2	No	Yes	0	9	9
100	R:R:R144	R:R:Y311	4.12	No	Yes	0	9	9
101	R:R:V149	R:R:Y145	8.83	Yes	Yes	0	7	8
102	R:R:L233	R:R:Y145	8.21	No	Yes	0	4	8
103	R:R:A147	R:R:R158	5.53	No	Yes	0	8	6
104	R:R:I234	R:R:V148	6.14	No	No	0	8	8
105	R:R:H150	R:R:V149	11.07	No	Yes	0	6	7
106	R:R:K237	R:R:V149	7.59	No	Yes	0	5	7
107	R:R:H150	R:R:R153	7.9	No	No	0	6	4
108	R:R:T156	R:R:Y157	8.74	No	No	0	4	3
109	R:R:R159	R:R:T156	3.88	No	No	0	7	4
110	R:R:L168	R:R:W171	6.83	No	Yes	0	5	9
111	R:R:G169	R:R:L172	3.42	No	No	0	4	3
112	R:R:L179	R:R:P180	6.57	No	No	0	4	6
113	R:R:F211	R:R:P180	5.78	No	No	0	5	6
114	R:R:I181	R:R:L200	5.71	No	Yes	0	4	3
115	R:R:F184	R:R:I183	3.77	No	No	0	4	4
116	R:R:F184	R:R:W202	17.04	No	Yes	0	4	3
117	R:R:F184	R:R:P203	5.78	No	No	0	4	4
118	R:R:D186	R:R:R188	10.72	No	No	6	3	5
119	R:R:D186	R:R:Q201	3.92	No	No	6	3	1
120	R:R:P189	R:R:T187	3.5	No	No	0	1	5
121	R:R:C198	R:R:T187	8.45	No	No	0	9	5
122	R:R:Q201	R:R:R188	9.35	No	No	6	1	5
123	R:R:A197	R:R:N199	4.69	No	No	0	3	4
124	L:L:?1	R:R:N199	4.28	Yes	No	0	0	4
125	R:R:L200	R:R:W202	6.83	Yes	Yes	1	3	3
126	R:R:F211	R:R:L200	3.65	No	Yes	1	5	3
127	L:L:?1	R:R:L200	5.39	Yes	Yes	1	0	3
128	R:R:S208	R:R:W202	6.18	No	Yes	0	4	3
129	R:R:F211	R:R:W202	16.04	No	Yes	1	5	3
130	R:R:H204	R:R:P203	3.05	No	No	0	1	4
131	R:R:H204	R:R:W207	7.41	No	No	0	1	3
132	R:R:A209	R:R:L283	3.15	No	No	0	3	4
133	L:L:?1	R:R:V212	3.48	Yes	No	0	0	4
134	R:R:L218	R:R:Y214	5.86	No	No	0	5	3
135	L:L:?1	R:R:T215	5.74	Yes	No	1	0	5
136	R:R:F216	R:R:F220	8.57	No	No	1	5	8
137	R:R:F216	R:R:L221	4.87	No	No	0	5	4
138	R:R:F216	R:R:Y276	10.32	No	No	1	5	7
139	R:R:L217	R:R:L221	5.54	No	No	0	4	4
140	R:R:L217	R:R:L222	4.15	No	No	0	4	5
141	R:R:G219	R:R:P223	4.06	No	No	0	5	8
142	R:R:F220	R:R:M273	4.98	No	No	0	8	5
143	R:R:F220	R:R:Y276	13.41	No	No	1	8	7
144	R:R:F268	R:R:V224	3.93	No	No	0	9	6
145	R:R:I227	R:R:Y231	9.67	No	Yes	3	8	9
146	R:R:I227	R:R:V265	4.61	No	No	0	8	8
147	R:R:V261	R:R:Y231	12.62	No	Yes	0	7	9
148	R:R:F264	R:R:Y231	8.25	Yes	Yes	3	7	9
149	R:R:E254	R:R:M238	6.77	Yes	No	0	6	7
150	R:R:I257	R:R:M238	5.83	No	No	0	7	7
151	R:R:A242	R:R:R239	5.53	No	Yes	0	3	5
152	R:R:R239	R:R:R250	25.59	Yes	No	7	5	4
153	R:R:E254	R:R:R239	15.12	Yes	Yes	7	6	5
154	R:R:L243	R:R:Q248	13.31	No	No	0	3	2
155	R:R:E254	R:R:R250	5.82	Yes	No	7	6	4
156	R:R:K255	R:R:R250	17.33	No	No	0	5	4
157	R:R:R251	R:R:S253	14.5	No	No	0	2	4
158	R:R:E254	R:R:T258	4.23	Yes	No	0	6	6
159	R:R:F264	R:R:L260	9.74	Yes	No	0	7	8
160	R:R:F264	R:R:L310	7.31	Yes	No	3	7	8
161	R:R:F264	R:R:Y311	31.98	Yes	Yes	3	7	9
162	R:R:F268	R:R:W272	12.03	No	Yes	0	9	8
163	R:R:M273	R:R:V269	4.56	No	No	0	5	6
164	R:R:C271	R:R:N303	9.45	No	No	0	8	9
165	R:R:S300	R:R:W272	6.18	No	Yes	0	7	8
166	R:R:N303	R:R:W272	11.3	No	Yes	0	9	8
167	R:R:M273	R:R:P274	3.35	No	No	0	5	9
168	R:R:L299	R:R:P274	6.57	No	No	0	8	9
169	R:R:F275	R:R:Q279	3.51	Yes	No	1	6	6
170	R:R:F275	R:R:L297	7.31	Yes	No	0	6	4
171	R:R:F275	R:R:S300	3.96	Yes	No	0	6	7
172	L:L:?1	R:R:F275	14.24	Yes	Yes	1	0	6
173	L:L:?1	R:R:Y276	3.65	Yes	No	1	0	7
174	R:R:S296	R:R:V278	8.08	No	No	0	6	4
175	R:R:N282	R:R:Q279	6.6	No	No	0	3	6
176	L:L:?1	R:R:Q279	15.56	Yes	No	1	0	6
177	R:R:L288	R:R:N282	5.49	No	No	0	1	3
178	R:R:F284	R:R:L283	8.53	No	No	0	5	4
179	R:R:D289	R:R:V292	7.3	No	No	0	3	4
180	R:R:L297	R:R:N293	4.12	No	No	0	4	3
181	R:R:I298	R:R:V295	4.61	Yes	No	0	5	4
182	R:R:L297	R:R:Y301	4.69	No	Yes	0	4	6
183	R:R:N303	R:R:N307	8.17	No	No	0	9	9
184	R:R:N307	R:R:Y311	8.14	No	Yes	0	9	9
185	R:R:L310	R:R:Y311	4.69	No	Yes	3	8	9
186	R:R:F318	R:R:G312	6.02	Yes	No	0	8	7
187	R:R:F318	R:R:S315	5.28	Yes	No	0	8	8
188	R:R:D316	R:R:R319	3.57	No	No	0	4	8
189	R:R:N317	R:R:R320	7.23	No	No	0	6	4
190	R:R:A108	R:R:Q51	3.03	No	No	0	4	6
191	R:R:L281	R:R:V278	2.98	No	No	0	4	4
192	R:R:A107	R:R:H294	2.93	No	Yes	0	4	3
193	R:R:N83	R:R:T82	2.92	Yes	No	2	8	8
194	R:R:I84	R:R:K164	2.91	Yes	No	0	5	2
195	R:R:F114	R:R:P113	2.89	Yes	No	0	6	3
196	R:R:E254	R:R:V235	2.85	Yes	Yes	0	6	5
197	R:R:L87	R:R:M78	2.83	No	No	0	6	7
198	R:R:I84	R:R:N167	2.83	Yes	No	0	5	7
199	R:R:L310	R:R:M263	2.83	No	No	0	8	6
200	R:R:L73	R:R:L87	2.77	No	No	0	4	6
201	R:R:L95	R:R:L98	2.77	No	No	0	7	5
202	R:R:A154	R:R:R158	2.77	No	Yes	0	5	6
203	R:R:L260	R:R:L314	2.77	No	No	0	8	6
204	R:R:M47	R:R:Q51	2.72	No	No	0	4	6
205	R:R:E94	R:R:M97	2.71	No	No	0	7	7
206	R:R:C230	R:R:Y145	2.69	No	Yes	0	7	8
207	R:R:F135	R:R:V170	2.62	No	No	0	6	7
208	R:R:Q248	R:R:Q249	2.56	No	No	0	2	3
209	R:R:V146	R:R:Y145	2.52	No	Yes	0	5	8
210	R:R:K256	R:R:R259	2.48	No	No	0	7	6
211	R:R:L152	R:R:R153	2.43	No	No	0	7	4
212	R:R:L243	R:R:R239	2.43	No	Yes	0	3	5
213	R:R:F96	R:R:N129	2.42	No	No	0	7	8
214	R:R:F70	R:R:R74	2.14	No	No	8	4	5
215	R:R:F70	R:R:Y75	2.06	No	No	8	4	5
216	R:R:R74	R:R:Y75	2.06	No	No	8	5	5
217	R:R:G64	R:R:P308	2.03	No	No	0	8	9
218	R:R:R251	R:R:W247	2	No	No	0	2	1
219	R:R:G64	R:R:V63	1.84	No	No	0	8	4
220	R:R:G228	R:R:V265	1.84	No	No	0	4	8
221	R:R:G236	R:R:V235	1.84	No	Yes	0	4	5
222	R:R:A55	R:R:C58	1.81	No	No	0	3	6
223	R:R:P274	R:R:S296	1.78	No	No	0	9	6
224	R:R:P223	R:R:T138	1.75	No	No	0	8	7
225	R:R:C52	R:R:V48	1.71	No	No	0	5	6
226	R:R:A92	R:R:S133	1.71	No	No	0	8	9
227	R:R:C271	R:R:V267	1.71	No	No	0	8	7
228	R:R:A90	R:R:V68	1.7	No	No	0	9	8
229	R:R:A92	R:R:T132	1.68	No	No	0	8	7
230	R:R:A226	R:R:T138	1.68	No	No	0	6	7
231	R:R:A90	R:R:I69	1.62	No	No	0	9	7
232	R:R:V148	R:R:V149	1.6	No	Yes	0	8	7
233	R:R:V212	R:R:V213	1.6	No	No	0	4	4
234	R:R:V235	R:R:V261	1.6	Yes	No	0	5	7
235	R:R:V266	R:R:V267	1.6	No	No	0	5	7
236	R:R:V277	R:R:V278	1.6	No	No	0	6	4
237	R:R:C58	R:R:L59	1.59	No	No	0	6	6
238	R:R:C271	R:R:L270	1.59	No	No	0	8	6
239	R:R:I69	R:R:V91	1.54	No	No	0	7	7
240	R:R:H150	R:R:P151	1.53	No	No	0	6	8
241	R:R:H204	R:R:P205	1.53	No	No	0	1	2
242	R:R:M238	R:R:S253	1.53	No	No	0	7	4
243	R:R:K237	R:R:V241	1.52	No	No	0	5	6
244	R:R:F114	R:R:G115	1.51	Yes	No	0	6	8
245	R:R:L283	R:R:S208	1.5	No	No	0	4	4
246	R:R:L118	R:R:V122	1.49	No	No	0	4	5
247	R:R:L280	R:R:V212	1.49	No	No	0	5	4
248	R:R:L225	R:R:V224	1.49	No	No	0	2	6
249	R:R:L232	R:R:V235	1.49	No	Yes	0	3	5
250	R:R:D289	R:R:T291	1.45	No	No	0	3	2
251	R:R:P160	R:R:R159	1.44	No	No	0	3	7
252	R:R:P189	R:R:R188	1.44	No	No	0	1	5
253	R:R:I53	R:R:L56	1.43	No	No	0	5	5
254	R:R:A185	R:R:R120	1.38	No	No	0	4	6
255	R:R:L218	R:R:L222	1.38	No	No	0	5	5
256	R:R:A240	R:R:R244	1.38	No	No	0	5	4
257	R:R:F70	R:R:V71	1.31	No	No	0	4	8
258	R:R:R259	R:R:T258	1.29	No	No	0	6	6
259	R:R:F313	R:R:I309	1.26	No	No	0	6	6
260	R:R:V210	R:R:W207	1.23	No	No	0	3	3
261	R:R:F313	R:R:L314	1.22	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y54	4.5375	4	4	6
2	R:R:N83	5.645	4	2	8
3	R:R:I84	4.11	4	0	5
4	R:R:Y85	7.465	4	2	7
5	R:R:V100	4.2025	4	0	7
6	R:R:W112	9.395	6	1	8
7	R:R:F114	7.1825	4	1	6
8	R:R:D126	9.1525	4	1	6
9	R:R:L128	6.0375	4	0	6
10	R:R:M130	5.225	4	1	7
11	R:R:F131	6.07667	6	1	6
12	R:R:Y145	5.5625	4	0	8
13	R:R:V149	7.2725	4	0	7
14	R:R:R158	5.936	5	2	6
15	R:R:W171	9.68	4	0	9
16	R:R:S174	4.235	4	0	8
17	R:R:L200	5.395	4	1	3
18	R:R:W202	11.5225	4	1	3
19	R:R:Y231	9.074	5	3	9
20	R:R:V235	1.945	4	0	5
21	R:R:R239	12.1675	4	7	5
22	R:R:E254	6.958	5	7	6
23	R:R:F264	14.32	4	3	7
24	R:R:W272	8.8325	4	0	8
25	R:R:F275	7.255	4	1	6
26	R:R:H294	4.8425	4	4	3
27	R:R:I298	6.4425	4	0	5
28	R:R:Y301	7.638	5	1	6
29	R:R:Y311	11.192	5	3	9
30	R:R:F318	6.84	6	0	8
31	L:L:?1	8.40846	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I298	R:R:Y54	32.3829	4.84	Yes	Yes	0	5	6
2	R:R:I50	R:R:Y54	11.8898	6.04	No	Yes	4	6	6
3	R:R:I298	R:R:V57	44.1466	3.07	Yes	No	0	5	7
4	R:R:C305	R:R:V57	49.9797	5.12	No	No	0	7	7
5	R:R:M97	R:R:V100	81.4798	3.04	No	Yes	0	7	7
6	R:R:C305	R:R:M97	55.7802	4.86	No	No	0	7	7
7	R:R:E94	R:R:M97	24.1092	2.71	No	No	0	7	7
8	R:R:E94	R:R:N65	18.1297	7.89	No	No	0	7	9
9	R:R:V100	R:R:Y301	95.4157	5.05	Yes	Yes	0	7	6
10	R:R:V103	R:R:Y301	40.1155	6.31	No	Yes	0	5	6
11	L:L:?1	R:R:V103	41.0308	13.93	Yes	No	0	0	5
12	L:L:?1	R:R:F131	62.26	6.64	Yes	Yes	1	0	6
13	R:R:F131	R:R:S174	52.1355	5.28	Yes	Yes	0	6	8
14	R:R:L128	R:R:S174	24.1376	4.5	Yes	Yes	0	6	8
15	R:R:L128	R:R:W171	43.7032	6.83	Yes	Yes	0	6	9
16	R:R:N88	R:R:W171	59.9252	5.65	No	Yes	0	9	9
17	R:R:N167	R:R:N88	50.8217	13.62	No	No	0	7	9
18	R:R:I84	R:R:N167	47.7872	2.83	Yes	No	0	5	7
19	R:R:I84	R:R:M78	42.0151	5.83	Yes	No	0	5	7
20	R:R:L87	R:R:M78	40.2416	2.83	No	No	0	6	7
21	R:R:I72	R:R:L87	36.7027	7.14	No	No	0	7	6
22	R:R:D126	R:R:Y301	40.2416	4.6	Yes	Yes	1	6	6
23	L:L:?1	R:R:D126	50.2034	16.92	Yes	Yes	1	0	6
24	R:R:F131	R:R:T178	24.5078	6.49	Yes	No	0	6	7
25	R:R:L128	R:R:T178	23.5804	5.9	Yes	No	0	6	7
26	R:R:S174	R:R:T132	25.2034	3.2	Yes	No	0	8	7
27	R:R:T132	R:R:W171	22.4089	19.41	No	Yes	0	7	9
28	R:R:F318	R:R:I72	28.1199	8.79	Yes	No	0	8	7
29	R:R:F318	R:R:N83	15.323	3.62	Yes	Yes	0	8	8
30	R:R:N83	R:R:T82	11.0682	2.92	Yes	No	2	8	8
31	R:R:R158	R:R:T82	11.7841	6.47	Yes	No	2	6	8
32	R:R:D143	R:R:R158	15.7297	7.15	No	Yes	2	8	6
33	R:R:D143	R:R:Y85	16.5555	10.34	No	Yes	2	8	7
34	R:R:L140	R:R:Y85	19.5534	10.55	No	Yes	0	9	7
35	R:R:L140	R:R:R144	20.5784	13.36	No	No	0	9	9
36	R:R:R144	R:R:Y311	52.644	4.12	No	Yes	0	9	9
37	R:R:N307	R:R:Y311	96.8353	8.14	No	Yes	0	9	9
38	R:R:N303	R:R:N307	97.356	8.17	No	No	0	9	9
39	R:R:N303	R:R:W272	100	11.3	No	Yes	0	9	8
40	R:R:M130	R:R:W272	85.7753	5.82	Yes	Yes	0	7	8
41	L:L:?1	R:R:M130	67.906	6.61	Yes	Yes	1	0	7
42	R:R:S300	R:R:W272	19.769	6.18	No	Yes	0	7	8
43	R:R:F275	R:R:S300	19.7161	3.96	Yes	No	0	6	7
44	R:R:F275	R:R:L297	19.1059	7.31	Yes	No	0	6	4
45	R:R:L297	R:R:Y301	17.2104	4.69	No	Yes	0	4	6
46	L:L:?1	R:R:W112	25.663	5.32	Yes	Yes	1	0	8
47	R:R:C198	R:R:W112	13.2485	3.92	No	Yes	1	9	8
48	R:R:C198	R:R:T187	11.841	8.45	No	No	0	9	5
49	L:L:?1	R:R:L200	25.4068	5.39	Yes	Yes	1	0	3
50	R:R:F268	R:R:W272	12.0688	12.03	No	Yes	0	9	8
51	R:R:R144	R:R:Y231	43.4226	7.2	No	Yes	0	9	9
52	R:R:F264	R:R:Y231	38.8871	8.25	Yes	Yes	3	7	9
53	R:R:F264	R:R:Y311	42.727	31.98	Yes	Yes	3	7	9
54	R:R:S141	R:R:Y231	32.5334	7.63	No	Yes	3	9	9
55	R:R:C230	R:R:S141	30.5768	3.44	No	No	0	7	9
56	R:R:C230	R:R:Y145	26.2732	2.69	No	Yes	0	7	8
57	R:R:V149	R:R:Y145	19.7568	8.83	Yes	Yes	0	7	8
58	R:R:F184	R:R:W202	10.3889	17.04	No	Yes	0	4	3
59	R:R:L200	R:R:W202	17.4219	6.83	Yes	Yes	1	3	3
60	L:L:?1	R:R:Y276	23.0678	3.65	Yes	No	1	0	7
61	R:R:F220	R:R:Y276	13.0654	13.41	No	No	1	8	7
62	R:R:F220	R:R:M273	11.841	4.98	No	No	0	8	5
63	R:R:V261	R:R:Y231	43.0646	12.62	No	Yes	0	7	9
64	R:R:E254	R:R:V235	34.6038	2.85	Yes	Yes	0	6	5
65	R:R:V235	R:R:V261	40.9575	1.6	Yes	No	0	5	7
66	R:R:E254	R:R:M238	11.1658	6.77	Yes	No	0	6	7
67	R:R:E254	R:R:R239	10.9014	15.12	Yes	Yes	7	6	5
68	R:R:M47	R:R:Q51	11.7719	2.72	No	No	0	4	6
69	R:R:H294	R:R:Y54	14.5542	3.27	Yes	Yes	4	3	6
70	R:R:F131	R:R:M130	18.7561	4.98	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D126	R:R:F96	4.78	1	Yes	No	6	7	1	2
R:R:F96	R:R:Y301	17.54	1	No	Yes	7	6	2	2
R:R:D126	R:R:S99	10.31	1	Yes	No	6	6	1	2
R:R:F102	R:R:W112	4.01	1	No	Yes	5	8	2	1
R:R:F102	R:R:F114	4.29	1	No	Yes	5	6	2	2
R:R:V103	R:R:Y301	6.31	0	No	Yes	5	6	1	2
L:L:?1	R:R:V103	13.93	1	Yes	No	0	5	0	1
R:R:S106	R:R:W112	7.41	0	No	Yes	4	8	2	1
R:R:F114	R:R:W112	20.04	1	Yes	Yes	6	8	2	1
R:R:C119	R:R:W112	15.67	1	No	Yes	9	8	2	1
R:R:C198	R:R:W112	3.92	1	No	Yes	9	8	2	1
L:L:?1	R:R:W112	5.32	1	Yes	Yes	0	8	0	1
R:R:C119	R:R:C198	7.28	1	No	No	9	9	2	2
L:L:?1	R:R:L123	7.55	1	Yes	No	0	4	0	1
R:R:D126	R:R:Y301	4.6	1	Yes	Yes	6	6	1	2
L:L:?1	R:R:D126	16.92	1	Yes	Yes	0	6	0	1
R:R:G127	R:R:M130	3.49	0	No	Yes	5	7	2	1
R:R:F131	R:R:M130	4.98	1	Yes	Yes	6	7	1	1
R:R:M130	R:R:W272	5.82	1	Yes	Yes	7	8	1	2
L:L:?1	R:R:M130	6.61	1	Yes	Yes	0	7	0	1
R:R:F131	R:R:S174	5.28	1	Yes	Yes	6	8	1	2
R:R:F131	R:R:V177	9.18	1	Yes	No	6	5	1	2
R:R:F131	R:R:T178	6.49	1	Yes	No	6	7	1	2
R:R:F131	R:R:T215	3.89	1	Yes	No	6	5	1	1
L:L:?1	R:R:F131	6.64	1	Yes	Yes	0	6	0	1
R:R:I181	R:R:L200	5.71	0	No	Yes	4	3	2	1
R:R:A197	R:R:N199	4.69	0	No	No	3	4	2	1
L:L:?1	R:R:N199	4.28	1	Yes	No	0	4	0	1
R:R:L200	R:R:W202	6.83	1	Yes	Yes	3	3	1	2
R:R:F211	R:R:L200	3.65	1	No	Yes	5	3	2	1
L:L:?1	R:R:L200	5.39	1	Yes	Yes	0	3	0	1
R:R:F211	R:R:W202	16.04	1	No	Yes	5	3	2	2
L:L:?1	R:R:V212	3.48	1	Yes	No	0	4	0	1
L:L:?1	R:R:T215	5.74	1	Yes	No	0	5	0	1
R:R:F216	R:R:F220	8.57	1	No	No	5	8	2	2
R:R:F216	R:R:Y276	10.32	1	No	No	5	7	2	1
R:R:F220	R:R:Y276	13.41	1	No	No	8	7	2	1
R:R:S300	R:R:W272	6.18	0	No	Yes	7	8	2	2
R:R:F275	R:R:Q279	3.51	1	Yes	No	6	6	1	1
R:R:F275	R:R:L297	7.31	1	Yes	No	6	4	1	2
R:R:F275	R:R:S300	3.96	1	Yes	No	6	7	1	2
L:L:?1	R:R:F275	14.24	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y276	3.65	1	Yes	No	0	7	0	1
R:R:N282	R:R:Q279	6.6	0	No	No	3	6	2	1
L:L:?1	R:R:Q279	15.56	1	Yes	No	0	6	0	1
R:R:L297	R:R:Y301	4.69	0	No	Yes	4	6	2	2
R:R:V212	R:R:V213	1.6	0	No	No	4	4	1	2
R:R:L280	R:R:V212	1.49	0	No	No	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XMT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	241
Number of Links	261
Number of Hubs	31
Number of Links mediated by Hubs	121
Number of Communities	8
Number of Nodes involved in Communities	51
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	55982
Length Of Smallest Path	3
Average Path Length	14.3046
Length of Longest Path	28
Minimum Path Strength	1.24
Average Path Strength	6.94422
Maximum Path Strength	21.46
Minimum Path Correlation	0.7
Average Path Correlation	0.915969
Maximum Path Correlation	0.98
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	42.9015
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.9221
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • negative regulation of signaling • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of localization • positive regulation of arachidonate secretion • transport • regulation of lipid transport • regulation of arachidonate secretion • localization • arachidonate secretion • monocarboxylic acid transport • positive regulation of secretion • fatty acid transport • icosanoid transport • regulation of icosanoid secretion • icosanoid secretion • long-chain fatty acid transport • positive regulation of icosanoid secretion • organic anion transport • carboxylic acid transport • secretion • arachidonate transport • regulation of transport • lipid localization • lipid transport • positive regulation of lipid localization • establishment of localization • regulation of fatty acid transport • regulation of secretion • positive regulation of organic acid transport • organic acid transport • positive regulation of lipid transport • positive regulation of transport • regulation of lipid localization • macromolecule localization • regulation of organic acid transport • positive regulation of fatty acid transport • cell migration • cell motility • response to lipid • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • cellular response to chemical stimulus • response to hormone • response to chemical • response to steroid hormone • cellular response to lipid • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • neuron projection • plasma membrane bounded cell projection • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to alcohol • response to forskolin • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • ciliary basal body • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • synapse • cell junction • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	I8B
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	I8B
Name	(2~{S})-2-[[(2~{S})-4-azanyl-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanoyl]amino]-3-phenyl-propanimidic acid
Synonyms
Identifier
Formula	C24 H28 N4 O4 S
Molecular Weight	468.569
SMILES
PubChem	11442741
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	2
Total Bonds	63
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P31391
Sequence	>7XMT_nogp_Chain_R G M V A I Q C I Y A L V C L V G L V G N A L V I F V I L R Y A K M K T A T N I Y L L N L A V A D E L F M L S V P F V A S S A A L R H W P F G S V L C R A V L S V D G L N M F T S V F C L T V L S V D R Y V A V V H P L R A A T Y R R P S V A K L I N L G V W L A S L L V T L P I A I F A D T R P A C N L Q W P H P A W S A V F V V Y T F L L G F L L P V L A I G L C Y L L I V G K M R A V A L R A G W Q Q R R R S E K K I T R L V L M F V V V F V L C W M P F Y V V Q L L N L F L D A T V N H V S L I L S Y A N S C A N P I L Y G F L S D N F R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XMT	A	Peptide	Somatostatin	SST4	Homo sapiens	J-2156	-	Gi1/β1/γ2	2.8	2022-08-03	10.1038/s41422-022-00679-x
	7XMT (No Gprot)	A	Peptide	Somatostatin	SST4	Homo sapiens	J-2156	-		2.8	2022-08-03	10.1038/s41422-022-00679-x
	7XMS	A	Peptide	Somatostatin	SST4	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.9	2022-08-03	10.1038/s41422-022-00679-x
	7XMS (No Gprot)	A	Peptide	Somatostatin	SST4	Homo sapiens	Somatostatin-14	-		2.9	2022-08-03	10.1038/s41422-022-00679-x

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