psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q25	R:R:Y21	6.76	No	No	0	4	4
2	R:R:N274	R:R:Y21	8.14	No	No	0	4	4
3	R:R:F277	R:R:Y21	16.5	No	No	0	4	4
4	R:R:K22	R:R:T24	7.51	No	No	0	4	5
5	R:R:F28	R:R:Y32	11.35	No	Yes	1	6	8
6	R:R:E281	R:R:F28	9.33	Yes	No	1	5	6
7	R:R:F28	R:R:W285	5.01	No	Yes	1	6	4
8	R:R:D84	R:R:P29	4.83	No	No	0	5	5
9	R:R:L31	R:R:W285	7.97	No	Yes	0	4	4
10	R:R:E281	R:R:Y32	5.61	Yes	Yes	1	5	8
11	R:R:L284	R:R:Y32	3.52	Yes	Yes	1	6	8
12	R:R:W285	R:R:Y32	12.54	Yes	Yes	1	4	8
13	R:R:S288	R:R:Y32	3.82	No	Yes	1	6	8
14	R:R:F77	R:R:L35	3.65	Yes	Yes	1	8	7
15	R:R:L35	R:R:W285	6.83	Yes	Yes	1	7	4
16	R:R:L35	R:R:S288	4.5	Yes	No	1	7	6
17	R:R:L289	R:R:L35	5.54	Yes	Yes	1	5	7
18	R:R:F36	R:R:L40	7.31	Yes	No	0	7	6
19	R:R:F36	R:R:I74	3.77	Yes	No	0	7	5
20	R:R:F36	R:R:P78	5.78	Yes	No	0	7	9
21	R:R:G39	R:R:T42	5.46	No	Yes	0	8	7
22	R:R:P295	R:R:T42	6.99	No	Yes	0	9	7
23	R:R:F296	R:R:T42	5.19	No	Yes	0	6	7
24	R:R:D70	R:R:N43	9.42	No	Yes	0	9	9
25	R:R:I74	R:R:N43	4.25	No	Yes	0	5	9
26	R:R:N43	R:R:P295	6.52	Yes	No	0	9	9
27	R:R:L309	R:R:L45	4.15	No	No	3	6	6
28	R:R:A46	R:R:F50	5.55	No	Yes	0	8	7
29	R:R:Q52	R:R:R48	5.84	No	No	0	6	4
30	R:R:F299	R:R:I49	5.02	Yes	No	0	6	7
31	R:R:F50	R:R:L63	15.83	Yes	No	0	7	8
32	R:R:F50	R:R:V67	3.93	Yes	No	0	7	8
33	R:R:F299	R:R:F50	7.5	Yes	Yes	3	6	7
34	R:R:F305	R:R:F50	13.93	No	Yes	3	8	7
35	R:R:F51	R:R:K64	14.89	No	No	0	3	5
36	R:R:F51	R:R:I68	3.77	No	No	0	3	5
37	R:R:I53	R:R:K56	5.82	No	No	0	6	5
38	R:R:I53	R:R:I60	4.42	No	No	0	6	8
39	R:R:I61	R:R:S55	4.64	No	No	0	7	5
40	R:R:F62	R:R:N58	3.62	Yes	Yes	0	7	6
41	R:R:D121	R:R:N58	5.39	No	Yes	0	8	6
42	R:R:L138	R:R:N58	5.49	No	Yes	0	4	6
43	R:R:A141	R:R:N58	6.25	No	Yes	0	7	6
44	R:R:F59	R:R:I60	3.77	No	No	0	7	8
45	R:R:F59	R:R:L63	4.87	No	No	0	7	8
46	R:R:F59	R:R:I118	8.79	No	Yes	0	7	9
47	R:R:I60	R:R:K64	4.36	No	No	0	8	5
48	R:R:I61	R:R:K142	7.27	No	No	0	7	4
49	R:R:F114	R:R:F62	7.5	Yes	Yes	2	7	7
50	R:R:F62	R:R:L117	12.18	Yes	No	2	7	6
51	R:R:F62	R:R:I118	5.02	Yes	Yes	2	7	9
52	R:R:L63	R:R:Y298	7.03	No	Yes	0	8	9
53	R:R:F114	R:R:N65	16.92	Yes	No	2	7	9
54	R:R:N65	R:R:S145	5.96	No	No	2	9	6
55	R:R:D294	R:R:D70	5.32	No	No	0	9	9
56	R:R:F77	R:R:M73	3.73	Yes	Yes	1	8	6
57	R:R:F104	R:R:M73	3.73	Yes	Yes	1	6	6
58	R:R:A291	R:R:M73	4.83	No	Yes	0	8	6
59	R:R:F104	R:R:T76	6.49	Yes	No	0	6	6
60	R:R:F104	R:R:F77	4.29	Yes	Yes	1	6	8
61	R:R:F77	R:R:S288	3.96	Yes	No	1	8	6
62	R:R:F79	R:R:F95	10.72	No	No	4	6	1
63	R:R:F79	R:R:T100	11.67	No	No	4	6	5
64	R:R:D84	R:R:K80	12.44	No	No	0	5	6
65	R:R:E281	R:R:K80	5.4	Yes	No	0	5	6
66	R:R:L87	R:R:S83	7.51	No	No	0	4	6
67	R:R:R93	R:R:S83	7.91	Yes	No	0	7	6
68	R:R:S83	R:R:V96	9.7	No	No	0	6	5
69	R:R:G88	R:R:L87	3.42	No	No	0	4	4
70	R:R:L87	R:R:L92	13.84	No	No	0	4	6
71	R:R:G88	R:R:P91	4.06	No	No	0	4	3
72	R:R:P167	R:R:T89	3.5	Yes	No	0	1	4
73	R:R:G90	R:R:P91	4.06	No	No	0	9	3
74	R:R:C97	R:R:R93	4.18	No	Yes	1	9	7
75	R:R:C175	R:R:R93	8.36	No	Yes	1	9	7
76	R:R:P167	R:R:T94	5.25	Yes	No	0	1	4
77	R:R:F95	R:R:T100	6.49	No	No	4	1	5
78	R:R:C175	R:R:C97	7.28	No	No	1	9	9
79	R:R:Q98	R:R:T163	5.67	No	No	0	7	5
80	R:R:S101	R:R:Y105	5.09	No	No	1	6	5
81	L:L:?1	R:R:S101	7.46	Yes	No	1	0	6
82	R:R:M160	R:R:V102	7.61	No	No	0	4	6
83	L:L:?1	R:R:V102	8.33	Yes	No	0	0	6
84	R:R:F106	R:R:I103	6.28	Yes	No	0	5	4
85	R:R:F104	R:R:L284	3.65	Yes	Yes	1	6	6
86	R:R:L284	R:R:Y105	3.52	Yes	No	1	6	5
87	L:L:?1	R:R:Y105	26.94	Yes	No	1	0	5
88	R:R:F106	R:R:T107	3.89	Yes	No	0	5	9
89	R:R:F106	R:R:I110	3.77	Yes	Yes	0	5	7
90	R:R:F106	R:R:F153	4.29	Yes	No	0	5	3
91	R:R:F106	R:R:S156	10.57	Yes	No	0	5	6
92	R:R:M108	R:R:Y109	5.99	No	No	0	7	7
93	R:R:F249	R:R:M108	3.73	Yes	No	0	9	7
94	R:R:M108	R:R:T287	4.52	No	No	0	7	8
95	R:R:C194	R:R:Y109	10.75	No	No	0	5	7
96	L:L:?1	R:R:Y109	10.92	Yes	No	0	0	7
97	R:R:I110	R:R:W149	12.92	Yes	No	0	7	9
98	R:R:I110	R:R:M152	5.83	Yes	No	0	7	7
99	R:R:F198	R:R:I112	3.77	Yes	No	5	9	8
100	R:R:I112	R:R:N201	5.66	No	No	0	8	9
101	R:R:F249	R:R:I112	7.54	Yes	No	5	9	8
102	R:R:F114	R:R:L117	3.65	Yes	No	2	7	6
103	R:R:F114	R:R:S145	6.61	Yes	No	2	7	6
104	R:R:F114	R:R:I148	10.05	Yes	No	0	7	7
105	R:R:F114	R:R:W149	4.01	Yes	No	0	7	9
106	R:R:F245	R:R:L115	3.65	No	No	0	9	8
107	R:R:L115	R:R:Y298	3.52	No	Yes	0	8	9
108	R:R:G116	R:R:T119	3.64	No	Yes	0	7	9
109	R:R:G116	R:R:N201	5.09	No	No	0	7	9
110	R:R:I118	R:R:R122	6.26	Yes	No	2	9	9
111	R:R:I118	R:R:Y298	6.04	Yes	Yes	2	9	9
112	R:R:T119	R:R:V205	11.11	Yes	No	0	9	7
113	R:R:T119	R:R:Y209	9.99	Yes	Yes	0	9	9
114	R:R:D121	R:R:K125	8.3	No	No	0	8	8
115	R:R:R122	R:R:Y209	4.12	No	Yes	0	9	9
116	R:R:R122	R:R:Y298	7.2	No	Yes	2	9	9
117	R:R:T127	R:R:Y123	11.24	No	Yes	0	7	8
118	R:R:C208	R:R:Y123	9.41	Yes	Yes	0	6	8
119	R:R:L211	R:R:Y123	8.21	Yes	Yes	0	4	8
120	R:R:I212	R:R:T126	9.12	No	No	0	8	8
121	R:R:R128	R:R:T127	3.88	No	No	0	6	7
122	R:R:E215	R:R:T127	4.23	Yes	No	0	5	7
123	R:R:N134	R:R:N137	6.81	No	No	0	4	5
124	R:R:F151	R:R:L155	12.18	No	No	0	4	5
125	R:R:P158	R:R:W186	12.16	No	No	0	8	5
126	L:L:?1	R:R:N159	10.23	Yes	No	0	0	5
127	R:R:G183	R:R:L162	5.13	No	No	0	3	4
128	R:R:P167	R:R:Q166	4.74	Yes	No	0	1	1
129	R:R:K170	R:R:P167	6.69	No	Yes	0	1	1
130	R:R:L178	R:R:P167	6.57	No	Yes	0	4	1
131	R:R:D169	R:R:N171	6.73	No	No	0	1	5
132	R:R:D169	R:R:V172	7.3	No	No	0	1	2
133	R:R:K174	R:R:S176	7.65	No	No	0	3	4
134	R:R:F177	R:R:K174	9.93	No	No	0	5	3
135	L:L:?1	R:R:C175	3.94	Yes	No	1	0	9
136	R:R:Q263	R:R:S176	11.55	Yes	No	0	4	4
137	R:R:G183	R:R:K179	3.49	No	Yes	0	3	5
138	R:R:K179	R:R:L184	7.05	Yes	No	0	5	3
139	R:R:H187	R:R:K179	9.17	Yes	Yes	0	4	5
140	R:R:F182	R:R:V185	3.93	No	No	0	3	1
141	R:R:V190	R:R:W186	4.9	No	No	0	5	5
142	R:R:H187	R:R:N191	16.58	Yes	Yes	1	4	5
143	L:L:?1	R:R:H187	11.98	Yes	Yes	1	0	4
144	R:R:E188	R:R:T264	5.64	No	No	0	4	3
145	L:L:?1	R:R:V190	3.7	Yes	No	0	0	5
146	R:R:N191	R:R:R256	6.03	Yes	Yes	1	5	6
147	R:R:N191	R:R:T260	14.62	Yes	No	1	5	5
148	L:L:?1	R:R:N191	6.82	Yes	Yes	1	0	5
149	R:R:Q195	R:R:W199	6.57	Yes	No	0	3	4
150	R:R:H253	R:R:Q195	12.36	No	Yes	0	8	3
151	R:R:Q195	R:R:R256	3.5	Yes	Yes	0	3	6
152	R:R:I257	R:R:Q195	4.12	No	Yes	0	6	3
153	R:R:F198	R:R:W199	12.03	Yes	No	0	9	4
154	R:R:F198	R:R:F249	4.29	Yes	Yes	5	9	9
155	R:R:F198	R:R:H253	38.46	Yes	No	0	9	8
156	R:R:F254	R:R:W199	6.01	No	No	0	5	4
157	R:R:F202	R:R:I206	8.79	Yes	No	0	6	4
158	R:R:F202	R:R:F245	5.36	Yes	No	0	6	9
159	R:R:F202	R:R:F246	5.36	Yes	No	7	6	5
160	R:R:F202	R:R:V250	3.93	Yes	Yes	7	6	6
161	R:R:I206	R:R:I242	4.42	No	No	0	4	7
162	R:R:V238	R:R:Y209	6.31	No	Yes	0	7	9
163	R:R:I241	R:R:Y209	10.88	No	Yes	0	7	9
164	R:R:I242	R:R:Y209	6.04	No	Yes	0	7	9
165	R:R:K214	R:R:L211	4.23	No	Yes	0	5	4
166	R:R:T213	R:R:V238	4.76	No	No	0	5	7
167	R:R:E215	R:R:R218	8.14	Yes	No	0	5	5
168	R:R:V221	R:R:Y217	7.57	No	No	0	1	4
169	R:R:R231	R:R:Y217	5.14	No	No	0	6	4
170	R:R:R222	R:R:S219	5.27	No	No	0	3	5
171	R:R:R224	R:R:Y220	17.49	No	No	0	3	4
172	R:R:G227	R:R:Y220	5.79	No	No	0	4	4
173	R:R:P230	R:R:Y220	9.74	No	No	0	5	4
174	R:R:G227	R:R:K228	3.49	No	No	0	4	3
175	R:R:P230	R:R:V229	3.53	No	No	0	5	4
176	R:R:K232	R:R:V229	4.55	No	No	0	5	4
177	R:R:N235	R:R:R231	6.03	No	No	0	5	6
178	R:R:K237	R:R:L301	4.23	No	No	0	7	6
179	R:R:I241	R:R:L301	8.56	No	No	0	7	6
180	R:R:F245	R:R:F249	7.5	No	Yes	0	9	9
181	R:R:F246	R:R:V250	5.24	No	Yes	7	5	6
182	R:R:C248	R:R:N290	9.45	No	No	0	8	9
183	R:R:F249	R:R:N290	14.5	Yes	No	0	9	9
184	R:R:P251	R:R:V250	3.53	No	Yes	0	9	6
185	R:R:F254	R:R:V250	6.55	No	Yes	0	5	6
186	R:R:F252	R:R:H253	4.53	Yes	No	0	7	8
187	R:R:F252	R:R:R256	5.34	Yes	Yes	0	7	6
188	R:R:F252	R:R:T283	9.08	Yes	No	0	7	6
189	R:R:F252	R:R:L284	3.65	Yes	Yes	0	7	6
190	R:R:F252	R:R:T287	5.19	Yes	No	0	7	8
191	R:R:R256	R:R:Y259	5.14	Yes	Yes	1	6	4
192	R:R:R256	R:R:T260	5.17	Yes	No	1	6	5
193	R:R:Q263	R:R:R256	3.5	Yes	Yes	1	4	6
194	L:L:?1	R:R:R256	8.3	Yes	Yes	1	0	6
195	R:R:I257	R:R:P258	5.08	No	No	0	6	5
196	R:R:Q263	R:R:Y259	12.4	Yes	Yes	1	4	4
197	R:R:F277	R:R:Y259	6.19	No	Yes	0	4	4
198	R:R:K280	R:R:Y259	28.66	No	Yes	1	5	4
199	L:L:?1	R:R:Y259	5.82	Yes	Yes	1	0	4
200	R:R:E273	R:R:S262	8.62	No	No	0	4	2
201	L:L:?1	R:R:Q263	14.88	Yes	Yes	1	0	4
202	R:R:F268	R:R:V267	6.55	No	No	0	1	1
203	R:R:F268	R:R:L276	4.87	No	No	0	1	4
204	R:R:D269	R:R:T271	4.34	No	No	0	6	2
205	R:R:E273	R:R:L276	3.98	No	No	0	4	4
206	R:R:N274	R:R:Y278	16.28	No	No	0	4	2
207	L:L:?1	R:R:K280	6.13	Yes	No	1	0	5
208	R:R:E281	R:R:L284	9.28	Yes	Yes	1	5	6
209	R:R:L286	R:R:W285	3.42	No	Yes	0	7	4
210	R:R:L289	R:R:W285	4.56	Yes	Yes	1	5	4
211	R:R:L289	R:R:L293	5.54	Yes	No	0	5	7
212	R:R:F299	R:R:F305	9.65	Yes	No	3	6	8
213	R:R:F299	R:R:L309	10.96	Yes	No	3	6	6
214	R:R:C302	R:R:S304	5.16	No	No	0	8	6
215	R:R:C302	R:R:F305	8.38	No	No	0	8	8
216	R:R:K303	R:R:R306	3.71	No	No	0	6	8
217	R:R:K303	R:R:N307	11.19	No	No	0	6	5
218	R:R:I81	R:R:P29	3.39	No	No	0	7	5
219	R:R:Q124	R:R:Y123	3.38	No	Yes	0	6	8
220	R:R:E188	R:R:Y192	3.37	No	No	0	4	4
221	R:R:K233	R:R:P230	3.35	No	No	0	8	5
222	R:R:C248	R:R:I247	3.27	No	No	0	8	6
223	R:R:F300	R:R:R306	3.21	No	No	0	7	8
224	R:R:C292	R:R:L289	3.17	No	Yes	0	7	5
225	R:R:T100	R:R:T76	3.14	No	No	0	5	6
226	R:R:I49	R:R:S308	3.1	No	No	0	7	5
227	R:R:I110	R:R:S69	3.1	Yes	No	0	7	8
228	R:R:A272	R:R:D269	3.09	No	No	0	1	6
229	R:R:M73	R:R:S111	3.07	Yes	No	0	6	9
230	R:R:I200	R:R:V196	3.07	No	No	0	5	4
231	R:R:I297	R:R:V244	3.07	No	No	0	7	7
232	R:R:M160	R:R:V99	3.04	No	No	0	4	4
233	R:R:L138	R:R:S55	3	No	No	0	4	5
234	R:R:L138	R:R:S133	3	No	No	0	4	4
235	R:R:L211	R:R:V207	2.98	Yes	No	0	4	3
236	R:R:L216	R:R:V234	2.98	No	No	0	8	7
237	R:R:N43	R:R:V67	2.96	Yes	No	0	9	8
238	R:R:L72	R:R:T107	2.95	No	No	0	6	9
239	R:R:L211	R:R:T210	2.95	Yes	No	0	4	1
240	R:R:I120	R:R:I204	2.94	No	Yes	6	5	6
241	R:R:N134	R:R:T132	2.92	No	No	0	4	6
242	R:R:F268	R:R:P258	2.89	No	No	0	1	5
243	R:R:I143	R:R:L139	2.85	No	No	0	3	4
244	R:R:I204	R:R:L203	2.85	Yes	No	0	6	3
245	R:R:E215	R:R:T126	2.82	Yes	No	0	5	8
246	R:R:K136	R:R:N134	2.8	No	No	0	7	4
247	R:R:D294	R:R:I297	2.8	No	No	0	9	7
248	R:R:A243	R:R:F239	2.77	No	No	0	4	4
249	R:R:H187	R:R:T264	2.74	Yes	No	0	4	3
250	R:R:F36	R:R:T33	2.59	Yes	No	0	7	5
251	R:R:F114	R:R:T66	2.59	Yes	No	0	7	9
252	R:R:R93	R:R:T89	2.59	Yes	No	0	7	4
253	R:R:K131	R:R:R128	2.48	No	No	0	5	6
254	R:R:F153	R:R:L157	2.44	No	No	0	3	4
255	R:R:F182	R:R:L162	2.44	No	No	0	3	4
256	R:R:K22	R:R:Y278	2.39	No	No	0	4	2
257	R:R:A85	R:R:P29	1.87	No	No	0	3	5
258	R:R:G39	R:R:V38	1.84	No	No	0	8	6
259	R:R:G140	R:R:I143	1.76	No	No	0	2	3
260	R:R:G44	R:R:M47	1.75	No	No	0	3	7
261	R:R:A255	R:R:V279	1.7	No	No	0	4	5
262	R:R:C208	R:R:T119	1.69	Yes	Yes	0	6	9
263	R:R:C270	R:R:T271	1.69	No	No	0	6	2
264	R:R:A255	R:R:T283	1.68	No	No	0	4	6
265	R:R:K136	R:R:P135	1.67	No	No	0	7	4
266	R:R:C208	R:R:I120	1.64	Yes	No	6	6	5
267	R:R:C208	R:R:I204	1.64	Yes	Yes	6	6	6
268	R:R:S133	R:R:S57	1.63	No	No	0	4	7
269	R:R:S282	R:R:V279	1.62	No	No	0	5	5
270	R:R:S219	R:R:T223	1.6	No	No	0	5	3
271	R:R:V234	R:R:V238	1.6	No	No	0	7	7
272	R:R:T33	R:R:V34	1.59	No	No	0	5	4
273	R:R:T275	R:R:V279	1.59	No	No	0	1	5
274	R:R:I148	R:R:S113	1.55	No	No	0	7	5
275	R:R:I143	R:R:V147	1.54	No	No	0	3	3
276	R:R:I189	R:R:V185	1.54	No	No	0	5	1
277	R:R:I41	R:R:T42	1.52	No	Yes	0	4	7
278	R:R:K174	R:R:V172	1.52	No	No	0	3	2
279	R:R:K228	R:R:V226	1.52	No	No	0	3	3
280	R:R:A272	R:R:E273	1.51	No	No	0	1	4
281	R:R:K179	R:R:T163	1.5	Yes	No	0	5	5
282	R:R:L261	R:R:V267	1.49	No	No	0	4	1
283	R:R:L30	R:R:T33	1.47	No	No	0	4	5
284	R:R:I189	R:R:I193	1.47	No	No	0	5	5
285	R:R:I193	R:R:I197	1.47	No	No	0	5	5
286	R:R:I200	R:R:I204	1.47	No	Yes	0	5	6
287	R:R:I240	R:R:I297	1.47	No	No	0	6	7
288	R:R:N235	R:R:T213	1.46	No	No	0	5	5
289	R:R:I23	R:R:K22	1.45	No	No	0	5	4
290	R:R:P129	R:R:R128	1.44	No	No	0	8	6
291	R:R:F130	R:R:P129	1.44	No	No	0	5	8
292	R:R:E181	R:R:S180	1.44	No	No	0	4	5
293	R:R:I148	R:R:L144	1.43	No	No	0	7	5
294	R:R:I193	R:R:L155	1.43	No	No	0	5	5
295	R:R:I161	R:R:L157	1.43	No	No	0	5	4
296	R:R:I161	R:R:L162	1.43	No	No	0	5	4
297	R:R:L45	R:R:M312	1.41	No	No	3	6	3
298	R:R:L309	R:R:M312	1.41	No	No	3	6	3
299	R:R:L82	R:R:L92	1.38	No	No	0	3	6
300	R:R:L154	R:R:L155	1.38	No	No	0	4	5
301	R:R:K173	R:R:Q25	1.36	No	No	0	4	4
302	R:R:E181	R:R:L184	1.33	No	No	0	4	3
303	R:R:F37	R:R:V38	1.31	No	No	0	5	6
304	R:R:R224	R:R:T223	1.29	No	No	0	3	3
305	R:R:F300	R:R:K237	1.24	No	No	0	7	7
306	R:R:N164	R:R:R165	1.21	No	No	0	4	4
307	R:R:L261	R:R:R265	1.21	No	No	0	4	3
308	R:R:E215	R:R:R222	1.16	Yes	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y32	7.368	5	1	8
2	R:R:L35	5.13	4	1	7
3	R:R:F36	4.8625	4	0	7
4	R:R:T42	4.79	4	0	7
5	R:R:N43	5.7875	4	0	9
6	R:R:F50	9.348	5	3	7
7	R:R:N58	5.1875	4	0	6
8	R:R:F62	7.08	4	2	7
9	R:R:M73	3.84	4	1	6
10	R:R:F77	3.9075	4	1	8
11	R:R:R93	5.76	4	1	7
12	R:R:F104	4.54	4	1	6
13	R:R:F106	5.76	5	0	5
14	R:R:I110	6.405	4	0	7
15	R:R:F114	7.33286	7	2	7
16	R:R:I118	6.5275	4	2	9
17	R:R:T119	6.6075	4	0	9
18	R:R:Y123	8.06	4	0	8
19	R:R:P167	5.35	5	0	1
20	R:R:K179	5.3025	4	0	5
21	R:R:H187	10.1175	4	1	4
22	R:R:N191	11.0125	4	1	5
23	R:R:Q195	6.6375	4	0	3
24	R:R:F198	14.6375	4	5	9
25	R:R:F202	5.86	4	7	6
26	R:R:I204	2.225	4	6	6
27	R:R:C208	3.595	4	6	6
28	R:R:Y209	7.468	5	0	9
29	R:R:L211	4.5925	4	0	4
30	R:R:E215	4.0875	4	0	5
31	R:R:F249	7.512	5	5	9
32	R:R:V250	4.8125	4	7	6
33	R:R:F252	5.558	5	0	7
34	R:R:R256	5.28286	7	1	6
35	R:R:Y259	11.642	5	1	4
36	R:R:Q263	10.5825	4	1	4
37	R:R:E281	7.405	4	1	5
38	R:R:L284	4.724	5	1	6
39	R:R:W285	6.72167	6	1	4
40	R:R:L289	4.7025	4	1	5
41	R:R:Y298	5.9475	4	2	9
42	R:R:F299	8.2825	4	3	6
43	L:L:?1	9.65	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N274	R:R:Y21	16.3117	8.14	No	No	0	4	4
2	R:R:F277	R:R:Y21	25.2304	16.5	No	No	0	4	4
3	R:R:N274	R:R:Y278	13.0824	16.28	No	No	0	4	2
4	R:R:L284	R:R:Y32	25.5737	3.52	Yes	Yes	1	6	8
5	R:R:L284	R:R:Y105	14.8433	3.52	Yes	No	1	6	5
6	L:L:?1	R:R:Y105	15.6506	26.94	Yes	No	1	0	5
7	L:L:?1	R:R:Y259	15.5298	5.82	Yes	Yes	1	0	4
8	R:R:F277	R:R:Y259	27.9957	6.19	No	Yes	0	4	4
9	R:R:E281	R:R:L284	16.1973	9.28	Yes	Yes	1	5	6
10	R:R:F252	R:R:L284	52.654	3.65	Yes	Yes	0	7	6
11	R:R:F252	R:R:R256	22.8148	5.34	Yes	Yes	0	7	6
12	R:R:R256	R:R:Y259	15.1039	5.14	Yes	Yes	1	6	4
13	R:R:W285	R:R:Y32	16.7504	12.54	Yes	Yes	1	4	8
14	R:R:D84	R:R:K80	10.0884	12.44	No	No	0	5	6
15	R:R:E281	R:R:K80	12.3006	5.4	Yes	No	0	5	6
16	R:R:F104	R:R:L284	23.8001	3.65	Yes	Yes	1	6	6
17	R:R:F36	R:R:I74	14.0678	3.77	Yes	No	0	7	5
18	R:R:I74	R:R:N43	16.369	4.25	No	Yes	0	5	9
19	R:R:N43	R:R:V67	45.0321	2.96	Yes	No	0	9	8
20	R:R:F50	R:R:V67	47.1172	3.93	Yes	No	0	7	8
21	R:R:F50	R:R:L63	68.7051	15.83	Yes	No	0	7	8
22	R:R:L63	R:R:Y298	68.864	7.03	No	Yes	0	8	9
23	R:R:L115	R:R:Y298	91.6216	3.52	No	Yes	0	8	9
24	R:R:F245	R:R:L115	92.092	3.65	No	No	0	9	8
25	R:R:F245	R:R:F249	100	7.5	No	Yes	0	9	9
26	R:R:F249	R:R:M108	87.5532	3.73	Yes	No	0	9	7
27	R:R:M108	R:R:Y109	67.4528	5.99	No	No	0	7	7
28	L:L:?1	R:R:Y109	66.7281	10.92	Yes	No	0	0	7
29	R:R:P295	R:R:T42	14.0678	6.99	No	Yes	0	9	7
30	R:R:N43	R:R:P295	16.369	6.52	Yes	No	0	9	9
31	R:R:D70	R:R:N43	11.6585	9.42	No	Yes	0	9	9
32	R:R:F299	R:R:F50	13.1778	7.5	Yes	Yes	3	6	7
33	R:R:F59	R:R:I60	18.8799	3.77	No	No	0	7	8
34	R:R:F59	R:R:L63	18.079	4.87	No	No	0	7	8
35	R:R:F59	R:R:I118	20.8887	8.79	No	Yes	0	7	9
36	R:R:I118	R:R:Y298	42.6356	6.04	Yes	Yes	2	9	9
37	R:R:L138	R:R:N58	13.5719	5.49	No	Yes	0	4	6
38	R:R:F62	R:R:N58	22.3508	3.62	Yes	Yes	0	7	6
39	R:R:F62	R:R:I118	55.2158	5.02	Yes	Yes	2	7	9
40	R:R:F114	R:R:F62	33.6533	7.5	Yes	Yes	2	7	7
41	R:R:L87	R:R:S83	11.6649	7.51	No	No	0	4	6
42	R:R:R93	R:R:S83	15.4536	7.91	Yes	No	0	7	6
43	R:R:C175	R:R:R93	27.9575	8.36	No	Yes	1	9	7
44	L:L:?1	R:R:C175	31.2758	3.94	Yes	No	1	0	9
45	R:R:R93	R:R:T89	11.6649	2.59	Yes	No	0	7	4
46	L:L:?1	R:R:H187	37.3212	11.98	Yes	Yes	1	0	4
47	R:R:H187	R:R:K179	36.5965	9.17	Yes	Yes	0	4	5
48	R:R:F106	R:R:F153	18.4095	4.29	Yes	No	0	5	3
49	R:R:F153	R:R:L157	18.3777	2.44	No	No	0	3	4
50	R:R:I161	R:R:L157	18.454	1.43	No	No	0	5	4
51	R:R:I161	R:R:L162	18.5684	1.43	No	No	0	5	4
52	R:R:G183	R:R:L162	25.1478	5.13	No	No	0	3	4
53	R:R:G183	R:R:K179	26.7561	3.49	No	Yes	0	3	5
54	R:R:F106	R:R:I110	18.9816	3.77	Yes	Yes	0	5	7
55	R:R:F252	R:R:T287	20.3102	5.19	Yes	No	0	7	8
56	R:R:F114	R:R:W149	21.4735	4.01	Yes	No	0	7	9
57	R:R:I110	R:R:W149	20.164	12.92	Yes	No	0	7	9
58	R:R:F198	R:R:W199	22.6495	12.03	Yes	No	0	9	4
59	R:R:Q195	R:R:W199	30.0044	6.57	Yes	No	0	3	4
60	R:R:Q195	R:R:R256	37.0288	3.5	Yes	Yes	0	3	6
61	R:R:F198	R:R:H253	60.6128	38.46	Yes	No	0	9	8
62	R:R:H253	R:R:Q195	25.4402	12.36	No	Yes	0	8	3
63	R:R:F252	R:R:H253	44.7715	4.53	Yes	No	0	7	8
64	R:R:F198	R:R:I112	43.106	3.77	Yes	No	5	9	8
65	R:R:F249	R:R:I112	25.0334	7.54	Yes	No	5	9	8
66	R:R:I112	R:R:N201	66.6264	5.66	No	No	0	8	9
67	R:R:G116	R:R:N201	65.8509	5.09	No	No	0	7	9
68	R:R:G116	R:R:T119	65.3296	3.64	No	Yes	0	7	9
69	R:R:R122	R:R:Y298	19.522	7.2	No	Yes	2	9	9
70	R:R:T119	R:R:Y209	41.8537	9.99	Yes	Yes	0	9	9
71	R:R:F202	R:R:I206	14.322	8.79	Yes	No	0	6	4
72	R:R:I206	R:R:I242	13.6991	4.42	No	No	0	4	7
73	R:R:I242	R:R:Y209	13.2287	6.04	No	Yes	0	7	9
74	R:R:F202	R:R:F245	13.2287	5.36	Yes	No	0	6	9
75	R:R:R122	R:R:Y209	32.8905	4.12	No	Yes	0	9	9
76	R:R:C208	R:R:T119	64.0519	1.69	Yes	Yes	0	6	9
77	R:R:C208	R:R:Y123	53.3342	9.41	Yes	Yes	0	6	8
78	R:R:T127	R:R:Y123	42.1588	11.24	No	Yes	0	7	8
79	R:R:E215	R:R:T127	32.4836	4.23	Yes	No	0	5	7
80	R:R:I189	R:R:I193	11.5949	1.47	No	No	0	5	5
81	R:R:I189	R:R:V185	13.8771	1.54	No	No	0	5	1
82	R:R:F182	R:R:V185	16.1465	3.93	No	No	0	3	1
83	R:R:F182	R:R:L162	18.4032	2.44	No	No	0	3	4
84	R:R:K174	R:R:S176	16.3626	7.65	No	No	0	3	4
85	R:R:Q263	R:R:S176	19.5982	11.55	Yes	No	0	4	4
86	R:R:I257	R:R:Q195	39.9911	4.12	No	Yes	0	6	3
87	R:R:V238	R:R:Y209	23.5904	6.31	No	Yes	0	7	9
88	R:R:I241	R:R:Y209	21.2574	10.88	No	Yes	0	7	9
89	R:R:T213	R:R:V238	15.4027	4.76	No	No	0	5	7
90	R:R:N235	R:R:T213	12.2688	1.46	No	No	0	5	5
91	R:R:E215	R:R:R222	24.8045	1.16	Yes	No	0	5	3
92	R:R:R222	R:R:S219	22.783	5.27	No	No	0	3	5
93	R:R:S219	R:R:T223	20.7488	1.6	No	No	0	5	3
94	R:R:R224	R:R:T223	18.7019	1.29	No	No	0	3	3
95	R:R:R224	R:R:Y220	16.6423	17.49	No	No	0	3	4
96	R:R:K237	R:R:L301	15.4281	4.23	No	No	0	7	6
97	R:R:I241	R:R:L301	18.2315	8.56	No	No	0	7	6
98	R:R:F252	R:R:T283	13.1206	9.08	Yes	No	0	7	6
99	R:R:I257	R:R:P258	36.9907	5.08	No	No	0	6	5
100	R:R:E273	R:R:L276	18.721	3.98	No	No	0	4	4
101	R:R:F268	R:R:L276	21.7977	4.87	No	No	0	1	4
102	R:R:F268	R:R:P258	33.9775	2.89	No	No	0	1	5
103	R:R:A272	R:R:E273	12.5294	1.51	No	No	0	1	4
104	R:R:F300	R:R:K237	12.701	1.24	No	No	0	7	7
105	R:R:A255	R:R:T283	10.5206	1.68	No	No	0	4	6
106	R:R:F198	R:R:F249	36.8444	4.29	Yes	Yes	5	9	9
107	R:R:M108	R:R:T287	20.6916	4.52	No	No	0	7	8
108	R:R:Q263	R:R:R256	10.6414	3.5	Yes	Yes	1	4	6
109	L:L:?1	R:R:Q263	11.2199	14.88	Yes	Yes	1	0	4
110	L:L:?1	R:R:R256	12.9871	8.3	Yes	Yes	1	0	6
111	R:R:I118	R:R:R122	14.5636	6.26	Yes	No	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C97	R:R:R93	4.18	1	No	Yes	9	7	2	2
R:R:C175	R:R:R93	8.36	1	No	Yes	9	7	1	2
R:R:C175	R:R:C97	7.28	1	No	No	9	9	1	2
R:R:S101	R:R:Y105	5.09	1	No	No	6	5	1	1
L:L:?1	R:R:S101	7.46	1	Yes	No	0	6	0	1
R:R:M160	R:R:V102	7.61	0	No	No	4	6	2	1
L:L:?1	R:R:V102	8.33	1	Yes	No	0	6	0	1
R:R:L284	R:R:Y105	3.52	1	Yes	No	6	5	2	1
L:L:?1	R:R:Y105	26.94	1	Yes	No	0	5	0	1
R:R:M108	R:R:Y109	5.99	0	No	No	7	7	2	1
R:R:C194	R:R:Y109	10.75	0	No	No	5	7	2	1
L:L:?1	R:R:Y109	10.92	1	Yes	No	0	7	0	1
L:L:?1	R:R:N159	10.23	1	Yes	No	0	5	0	1
L:L:?1	R:R:C175	3.94	1	Yes	No	0	9	0	1
R:R:Q263	R:R:S176	11.55	1	Yes	No	4	4	1	2
R:R:H187	R:R:K179	9.17	1	Yes	Yes	4	5	1	2
R:R:V190	R:R:W186	4.9	0	No	No	5	5	1	2
R:R:H187	R:R:N191	16.58	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:H187	11.98	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:V190	3.7	1	Yes	No	0	5	0	1
R:R:N191	R:R:R256	6.03	1	Yes	Yes	5	6	1	1
R:R:N191	R:R:T260	14.62	1	Yes	No	5	5	1	2
L:L:?1	R:R:N191	6.82	1	Yes	Yes	0	5	0	1
R:R:Q195	R:R:R256	3.5	0	Yes	Yes	3	6	2	1
R:R:F252	R:R:R256	5.34	0	Yes	Yes	7	6	2	1
R:R:F252	R:R:L284	3.65	0	Yes	Yes	7	6	2	2
R:R:R256	R:R:Y259	5.14	1	Yes	Yes	6	4	1	1
R:R:R256	R:R:T260	5.17	1	Yes	No	6	5	1	2
R:R:Q263	R:R:R256	3.5	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:R256	8.3	1	Yes	Yes	0	6	0	1
R:R:Q263	R:R:Y259	12.4	1	Yes	Yes	4	4	1	1
R:R:F277	R:R:Y259	6.19	0	No	Yes	4	4	2	1
R:R:K280	R:R:Y259	28.66	1	No	Yes	5	4	1	1
L:L:?1	R:R:Y259	5.82	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Q263	14.88	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K280	6.13	1	Yes	No	0	5	0	1
R:R:H187	R:R:T264	2.74	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XXI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	279
Number of Links	308
Number of Hubs	43
Number of Links mediated by Hubs	159
Number of Communities	7
Number of Nodes involved in Communities	50
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	112
Number Of Links MetaPath	111
Number of Shortest Paths	50961
Length Of Smallest Path	3
Average Path Length	13.0047
Length of Longest Path	30
Minimum Path Strength	1.35
Average Path Strength	6.58198
Maximum Path Strength	25.41
Minimum Path Correlation	0.7
Average Path Correlation	0.924764
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	47.9979
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.7361
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of localization • regulation of biological process • transport • regulation of transport • regulation of monoatomic ion transport • biological regulation • positive regulation of biological process • establishment of localization • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • response to stimulus • response to stress • response to wounding • response to axon injury • regulation of body fluid levels • hemostasis • regulation of biological quality • chemotaxis • regulation of response to external stimulus • response to external stimulus • regulation of chemotaxis • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • positive regulation of locomotion • multicellular organismal process • regulation of cell motility • regulation of cellular process • cellular developmental process • regulation of microglial cell migration • glial cell migration • macrophage migration • regulation of glial cell migration • positive regulation of cell migration • neurogenesis • multicellular organism development • regulation of macrophage migration • gliogenesis • cell differentiation • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • anatomical structure development • positive regulation of microglial cell migration • cell migration • regulation of immune system process • regulation of mononuclear cell migration • cell motility • positive regulation of immune system process • positive regulation of cellular process • system development • developmental process • positive regulation of macrophage migration • regulation of leukocyte migration • microglial cell migration • positive regulation of leukocyte migration • nervous system development • leukocyte migration • positive regulation of glial cell migration • immune system process • mononuclear cell migration • cellular process • lamellipodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component organization • cellular component biogenesis • cellular component assembly • lamellipodium organization • cellular component organization or biogenesis • cell projection assembly • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • wound healing • homotypic cell-cell adhesion • cell activation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • platelet activation • visual system development • sensory system development • cellular response to stimulus • positive regulation of cell communication • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of signal transduction • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of intracellular signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of cell communication • phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of signaling • calcium-mediated signaling • substrate-dependent cell migration, cell extension • substrate-dependent cell migration • cellular localization • establishment of localization in cell • positive regulation of cell adhesion mediated by integrin • positive regulation of cell adhesion • regulation of cell adhesion mediated by integrin • regulation of cell adhesion • cell adhesion mediated by integrin • positive regulation of cellular component organization • regulation of cellular component organization • positive regulation of protein-containing complex assembly • regulation of protein-containing complex assembly • protein-containing complex assembly • regulation of integrin activation • positive regulation of integrin activation • cell surface receptor signaling pathway • protein-containing complex organization • positive regulation of cellular component biogenesis • regulation of cellular component biogenesis • positive regulation of integrin activation by cell surface receptor linked signal transduction • integrin activation • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • forebrain development • telencephalon glial cell migration • cerebral cortex development • telencephalon cell migration • forebrain cell migration • cerebral cortex cell migration • head development • animal organ development • brain development • cerebral cortex radially oriented cell migration • pallium development • central nervous system development • cerebral cortex radial glia-guided migration • telencephalon development • cellular response to nitrogen compound • cellular response to ATP • response to organophosphorus • response to oxygen-containing compound • response to nitrogen compound • response to ATP • response to purine-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • ruffle organization • ruffle assembly • positive regulation of cell projection organization • regulation of cell projection organization • regulation of cell projection assembly • positive regulation of ruffle assembly • regulation of plasma membrane bounded cell projection assembly • regulation of ruffle assembly • regulation of plasma membrane bounded cell projection organization • positive regulation of plasma membrane bounded cell projection assembly • cell periphery • cell body • cellular anatomical structure • cell body membrane • plasma membrane • membrane • cell surface • cell projection • plasma membrane region • cell projection membrane • plasma membrane bounded cell projection • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cell population proliferation • positive regulation of cell population proliferation • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • metal ion transport • calcium ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • dendrite • dendritic tree • neuron projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • camera-type eye development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	6AD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	6AD
Name	2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate)
Synonyms	2-methylthio-adenosine-5'-diphosphate
Identifier
Formula	C11 H17 N5 O10 P2 S
Molecular Weight	473.293
SMILES
PubChem	121990
Formal Charge	0
Total Atoms	46
Total Chiral Atoms	4
Total Bonds	48
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H244
Sequence	>7XXI_nogp_Chain_R D Y K I T Q V L F P L L Y T V L F F V G L I T N G L A M R I F F Q I R S K S N F I I F L K N T V I S D L L M I L T F P F K I L S D A K L G T G P L R T F V C Q V T S V I F Y F T M Y I S I S F L G L I T I D R Y Q K T T R P F K T S N P K N L L G A K I L S V V I W A F M F L L S L P N M I L T N R Q P R D K N V K K C S F L K S E F G L V W H E I V N Y I C Q V I F W I N F L I V I V C Y T L I T K E L Y R S Y V R T R G V G K V P R K K V N V K V F I I I A V F F I C F V P F H F A R I P Y T L S Q T R D V F D C T A E N T L F Y V K E S T L W L T S L N A C L D P F I Y F F L C K S F R N S L I S M L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7PP1	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	Selatogrel	-	-	2.78	2022-11-02	doi.org/10.1016/j.bcp.2022.115291
	4NTJ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	AZD1283	-	-	2.62	2014-03-26	doi.org/10.1038/nature13083
	4PXZ	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	2MeSADP	-	-	2.5	2014-04-30	doi.org/10.1038/nature13288
	4PY0	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	2MeSATP	-	-	3.1	2014-04-30	doi.org/10.1038/nature13288
	7XXI	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	2MeSADP	-	Gi2/β1/γ2	3	2023-06-07	doi.org/10.1093/procel/pwac025
	7XXI (No Gprot)	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	2MeSADP	-		3	2023-06-07	doi.org/10.1093/procel/pwac025

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