Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 3.9875444
2A:A:R38 4.244184
3A:A:H41 4.324556
4A:A:K53 74199
5A:A:T55 3.83409
6A:A:I56 4.27407
7A:A:V214 4.4275456
8A:A:F219 5.276558
9A:A:H220 6.5417
10A:A:M221 3.1425408
11A:A:F222 8.81417
12A:A:D223 5.4254199
13A:A:V224 4.6425419
14A:A:Q227 4.054519
15A:A:K233 4.468519
16A:A:W234 5.134519
17A:A:F238 4.99857719
18A:A:F246 3.602509
19A:A:V248 3.135467
20A:A:S250 4.4825406
21A:A:S251 4.2254209
22A:A:F273 4.094569
23A:A:W277 6.525666
24A:A:W281 6.8415
25A:A:F290 3.99509
26A:A:L291 4.38468
27A:A:Q294 5.66466
28A:A:L302 7.85754162
29A:A:F312 4.57333698
30A:A:F315 7.07506
31A:A:Y318 4.26696
32A:A:P321 4.082595
33A:A:D331 8.62754164
34A:A:Y339 4.456593
35A:A:F340 8.22597
36A:A:R342 4.808504
37A:A:F345 5.385668
38A:A:Y358 5.49474
39A:A:Y360 5.134578
40A:A:F363 4.97465
41A:A:T364 4.9545159
42A:A:C365 2.7475408
43A:A:D368 4.1554159
44A:A:N371 5.74754159
45A:A:R374 6.46254154
46A:A:F376 4.91658
47A:A:I383 3.42558
48A:A:Q384 3.77476
49A:A:R385 8.02475
50A:A:H387 4.6375458
51A:A:L388 3.324508
52B:B:L4 2.0125404
53B:B:L30 2.5325405
54B:B:R48 5.6675407
55B:B:R52 5.665407
56B:B:H54 6.223336139
57B:B:L55 7.4354186
58B:B:K57 8.818519
59B:B:Y59 6.056518
60B:B:M61 3.044106
61B:B:W63 4.6456107
62B:B:R68 9.96445
63B:B:L69 3.94445
64B:B:D76 4.865409
65B:B:I80 6.024138
66B:B:I81 3.6875447
67B:B:W82 9.16754139
68B:B:K89 5.1054139
69B:B:W99 5.79857719
70B:B:Y105 2.87333646
71B:B:L117 2.7625419
72B:B:Y124 4.2975406
73B:B:H142 5.56143719
74B:B:Y145 3.345818
75B:B:R150 4.6025406
76B:B:L152 3.9465243
77B:B:T159 4.99419
78B:B:D163 8.5725419
79B:B:W169 6.53618
80B:B:F180 5.094587
81B:B:H183 6.40833689
82B:B:F199 4.612589
83B:B:D205 4.7025489
84B:B:K209 8.9225486
85B:B:W211 7.698588
86B:B:Q220 8.3525427
87B:B:H225 7.805629
88B:B:I229 4.435427
89B:B:I232 3.842528
90B:B:F235 4.655717176
91B:B:F241 6.904526
92B:B:T243 4.534528
93B:B:D247 4.755429
94B:B:R251 9.386528
95B:B:F253 5.576526
96B:B:Q259 4.0925406
97B:B:Y264 4.33625
98B:B:I269 3.276524
99B:B:I273 4.6275426
100B:B:F278 3.4607
101B:B:L284 3.706505
102B:B:L285 3.375426
103B:B:Y289 5.73571727
104B:B:W297 4.64167628
105B:B:D298 6.83254229
106B:B:R304 7.55425
107B:B:L308 5.22754117
108B:B:H311 7.5925119
109B:B:R314 9.102518
110B:B:W332 8.22619
111B:B:D333 10.084119
112B:B:W339 7.0965119
113G:G:L19 3.145409
114G:G:Y40 5.54176
115G:G:D48 6.042509
116G:G:N59 6.9625449
117G:G:F61 3.31833648
118R:R:G55 3.1575436
119R:R:I58 4.828537
120R:R:N62 5.65667639
121R:R:N72 6.454266
122R:R:F80 4.738508
123R:R:D90 7.7975439
124R:R:F101 5.945406
125R:R:S123 4.0325436
126R:R:R138 7.17409
127R:R:L146 3.905457
128R:R:Y148 4.9458
129R:R:W165 4.3825409
130R:R:G172 1.98254126
131R:R:T187 4.4475402
132R:R:R192 8.1854124
133R:R:L202 6.834276
134R:R:F206 9.688538
135R:R:F210 7.8125437
136R:R:M213 2.7025438
137R:R:Y217 4.21857739
138R:R:H227 5.824577
139R:R:F260 4.20571739
140R:R:W264 4.464538
141R:R:Y270 7.3125144
142R:R:Y278 10.54754143
143R:R:Y282 11.6454144
144R:R:N293 4.392539
145R:R:I295 4.79436
146R:R:I296 3.434535
147R:R:N297 4.295439
148R:R:P298 4.3375439
149R:R:Y301 3.242539
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:Q19 B:B:D83 11.70613.92YesNo448
2A:A:Q19 B:B:N88 12.38773.96YesNo447
3A:A:N23 B:B:N88 24.77129.54NoNo077
4A:A:N23 B:B:K89 25.7885.6NoYes079
5B:B:I80 B:B:K89 13.2282.91YesYes1389
6B:B:H54 B:B:I80 13.73576.63YesYes1398
7B:B:H54 B:B:S74 28.30369.76YesNo099
8B:B:D76 B:B:S74 28.46892.94YesNo099
9B:B:K89 B:B:W82 13.2354.64YesYes1399
10B:B:H54 B:B:W82 13.73573.17YesYes1399
11B:B:D76 B:B:L55 29.296612.21YesYes096
12A:A:Y37 B:B:L55 30.29147.03NoYes046
13A:A:R42 A:A:Y37 30.457715.43NoNo094
14A:A:F376 R:R:L146 22.71834.87YesYes587
15A:A:F376 A:A:V214 22.35846.55YesYes586
16A:A:I372 A:A:V214 44.59494.61NoYes086
17A:A:I372 A:A:Q59 66.78054.12NoNo089
18A:A:N371 A:A:Q59 66.512213.2YesNo099
19A:A:D368 A:A:N371 66.5234.04YesYes1599
20A:A:C365 A:A:D368 1004.67YesYes089
21A:A:C365 A:A:Q294 99.79223.05YesYes086
22A:A:Q294 A:A:S250 49.57125.78YesYes066
23A:A:L291 A:A:S250 45.33936.01YesYes086
24A:A:L291 A:A:V248 87.62392.98YesYes687
25A:A:F246 A:A:V248 87.5182.62YesYes097
26A:A:F246 A:A:L46 39.43923.65YesNo098
27A:A:L44 A:A:L46 38.62194.15NoNo098
28A:A:F238 A:A:L44 38.152812.18YesNo099
29A:A:F238 B:B:W99 34.20517.02YesYes199
30A:A:F222 B:B:W99 31.963916.04YesYes179
31A:A:F222 A:A:R42 30.62424.28YesNo079
32A:A:F363 A:A:Q294 49.90657.03YesYes656
33A:A:F363 A:A:L291 45.48516.09YesYes658
34A:A:D368 A:A:T364 22.27734.34YesYes1599
35A:A:F290 A:A:T364 22.23877.78YesYes099
36A:A:F290 A:A:I245 22.48382.51YesNo097
37A:A:I245 A:A:L43 22.49072.85NoNo077
38A:A:L43 A:A:T242 22.66262.95NoNo078
39A:A:H41 A:A:T242 22.67754.11YesNo068
40A:A:F212 A:A:I372 22.23122.51NoNo098
41A:A:F212 A:A:F219 22.42738.57NoYes098
42A:A:F219 A:A:H41 44.59045.66YesYes586
43A:A:F219 A:A:V214 22.22273.93YesYes586
44A:A:H41 A:A:I383 67.2592.65YesYes568
45A:A:I383 R:R:L146 22.75442.85YesYes587
46A:A:R231 A:A:W234 47.95218NoYes099
47A:A:L272 A:A:R231 48.1174.86NoNo089
48A:A:D378 A:A:H362 11.455710.08NoNo079
49A:A:H362 A:A:R374 11.31726.77NoYes094
50A:A:D368 A:A:R374 11.27213.57YesYes1594
51A:A:D378 A:A:Y360 11.38414.6NoYes078
52A:A:R385 A:A:Y360 11.38678.23YesYes758
53A:A:R385 R:R:H227 12.098810.16YesYes757
54A:A:H387 A:A:I383 89.87593.98YesYes588
55A:A:H387 R:R:Y148 86.38422.18YesYes588
56A:A:Y391 R:R:S141 10.27873.82NoNo049
57A:A:Y391 R:R:R138 10.13318.52NoYes049
58R:R:T153 R:R:Y148 93.1667.49NoYes088
59R:R:P78 R:R:T153 93.11858.74NoNo058
60R:R:A77 R:R:P78 92.88081.87NoNo075
61R:R:A77 R:R:F80 92.83322.77NoYes078
62R:R:F80 R:R:I69 46.21462.51YesNo087
63R:R:I308 R:R:I69 46.15812.94NoNo087
64R:R:I308 R:R:I68 92.22924.42NoNo088
65R:R:I68 R:R:N72 91.97662.83NoYes2686
66R:R:N72 R:R:P73 91.74143.26YesNo065
67B:B:R52 R:R:P73 91.61937.21YesNo075
68B:B:F335 B:B:R52 91.25397.48NoYes047
69B:B:D333 B:B:F335 91.009713.14YesNo094
70B:B:D333 B:B:H311 90.63465.04YesYes1199
71B:B:H311 B:B:T329 45.13395.48YesNo098
72B:B:T329 B:B:W339 45.00749.7NoYes089
73B:B:L308 B:B:W339 87.66799.11YesYes1179
74B:B:L308 B:B:V296 86.89932.98YesNo075
75B:B:L284 B:B:V296 85.88484.47YesNo055
76B:B:L284 B:B:R283 81.24072.43YesNo059
77B:B:L300 B:B:R283 79.1743.64NoNo069
78B:B:L300 G:G:C41 78.91564.76NoNo067
79B:B:G282 G:G:C41 78.65711.96NoNo097
80B:B:F235 B:B:G282 78.39863.01YesNo069
81B:B:F235 B:B:F278 73.22368.57YesYes067
82B:B:F278 B:B:L252 33.0752.44YesNo077
83B:B:L252 B:B:Y264 32.81433.52NoYes075
84B:B:C250 B:B:Y264 53.06294.03NoYes285
85B:B:C250 B:B:G244 52.01291.96NoNo285
86B:B:G244 B:B:T243 51.5133.64NoYes258
87B:B:F241 B:B:T243 20.50392.59YesYes268
88B:B:F222 B:B:F241 15.249812.86NoYes286
89B:B:F222 B:B:Q220 29.45237.03NoYes287
90B:B:D258 B:B:Q220 25.246918.27NoYes277
91B:B:D258 B:B:R22 24.19613.57NoNo076
92B:B:I18 B:B:R22 23.14445.01NoNo076
93B:B:I18 G:G:L19 21.04081.43NoYes079
94G:G:L15 G:G:L19 13.67772.77NoYes029
95G:G:L15 G:G:Q11 12.62572.66NoNo023
96G:G:A12 G:G:Q11 11.57371.52NoNo053
97R:R:F80 R:R:N305 46.47572.42YesNo088
98R:R:I308 R:R:N305 46.19315.66NoNo088
99B:B:H311 B:B:K337 45.26476.55YesNo1196
100B:B:K337 B:B:W339 45.00734.64NoYes1169
101B:B:F278 B:B:L285 39.11252.44YesYes076
102B:B:L285 B:B:Y264 32.81723.52YesYes265
103B:B:F253 B:B:T243 19.97815.19YesYes268
104B:B:F222 B:B:F253 15.25394.29NoYes286
105B:B:M262 B:B:Y264 11.58468.38NoYes245
106B:B:L30 B:B:M262 11.05852.83YesNo054
107B:B:D83 B:B:R68 22.727214.29NoYes485
108B:B:R68 B:B:Y85 32.870419.55YesNo454
109B:B:Y85 G:G:F61 26.70753.09NoYes448
110B:B:I338 G:G:F61 15.41042.51NoYes058
111B:B:I338 B:B:S84 13.3563.1NoNo055
112B:B:S84 B:B:W63 11.30143.71NoYes1057
113B:B:L69 B:B:R68 11.45962.43YesYes455
114B:B:L69 B:B:Y105 12.12032.34YesYes456
115B:B:H62 B:B:Y105 13.48583.27NoYes066
116B:B:H62 B:B:R150 13.14046.77NoYes066
117B:B:G109 B:B:Y105 29.12332.9NoYes056
118B:B:G109 B:B:S108 29.46331.86NoNo056
119B:B:N110 B:B:S108 30.14414.47NoNo046
120B:B:N110 B:B:Y111 30.82532.33NoNo044
121B:B:I123 B:B:Y111 31.50734.84NoNo064
122B:B:I123 B:B:I171 32.18991.47NoNo066
123B:B:I157 B:B:I171 32.53141.47NoNo076
124B:B:I157 B:B:T159 16.43043.04NoYes179
125B:B:H142 B:B:T159 16.5985.48YesYes199
126B:B:I157 B:B:W169 16.4433.52NoYes178
127B:B:H142 B:B:W169 18.1462.12YesYes198
128B:B:H142 B:B:S161 41.39716.74YesNo199
129B:B:G162 B:B:S161 41.90933.71NoNo199
130B:B:G162 B:B:Y145 42.05942.9NoYes198
131B:B:D83 B:B:T86 11.70395.78NoNo486
132B:B:N88 B:B:T86 12.04475.85NoNo476
133A:A:F246 A:A:L272 48.44754.87YesNo098
134A:A:W234 B:B:Y145 45.95032.89YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7Y3G
Class A
SubFamily Orphan
Type Orphan
SubType GPR12
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.77
Date 2023-06-07 
D.O.I. 10.1016/j.scib.2022.12.023
Net Summary
Imin 1.96
Number of Linked Nodes 816
Number of Links 990
Number of Hubs 149
Number of Links mediated by Hubs 557
Number of Communities 27
Number of Nodes involved in Communities 229
Number of Links involved in Communities 319
Path Summary
Number Of Nodes in MetaPath 135
Number Of Links MetaPath 134
Number of Shortest Paths 9093244
Length Of Smallest Path 3
Average Path Length 54.972
Length of Longest Path 85
Minimum Path Strength 1.3
Average Path Strength 4.90712
Maximum Path Strength 16.92
Minimum Path Correlation 0.7
Average Path Correlation 0.996217
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5625
Average % Of Corr. Nodes 30.3116
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.0969
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • cation binding   • ion binding   • phosphatidylcholine binding   • phospholipid binding   • lipid binding   • quaternary ammonium group binding   • small molecule binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • metabolic process   • regulation of metabolic process   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7Y3G_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GGKNTIVKQ 
SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND VTAIIFVVA 
SSNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL AEKVLAGKI 
EDYFPEFAR YTTPEDATP EPGDPRVTR AKYFIRDEF LRISTASGD 
GRHYCYPHF TCAVDTENI RRVFNDCRD IIQRMHLRQ YELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7Y3G_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7Y3G_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP47775
Sequence
>7Y3G_Chain_R
VNPWDIVLC TSGTLISCE NAIVVLIIF HNPSLRAPM FLLIGSLAL 
ADLLAGIGL ITNFVFAYL LQSEATKLV TIGLIVASF SASVCSLLA 
ITVDRYLSL YYALTYHSE RTVTFTYVM LVMLWGTSI CLGLLPVMG 
WNCLRDEST CSVVRPLTK NNAAILSVS FLFMFALML QLYIQICKI 
VMRHAHQIA LQHHFTRKG VSTLAIILG TFAACWMPF TLYSLIADY 
TYPSIYTYA TLLPATYNS IINPVIYAF RNQEIQKA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y3GAOrphanOrphanGPR12Homo sapiens--Gs/β1/γ22.772023-06-0710.1016/j.scib.2022.12.023
7Y3G (No Gprot) AOrphanOrphanGPR12Homo sapiens--2.772023-06-0710.1016/j.scib.2022.12.023




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