Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 3.9875474
2A:A:K53 74139
3A:A:T55 3.83409
4A:A:F219 5.276588
5A:A:H220 6.54127
6A:A:F222 8.814127
7A:A:D223 5.4254139
8A:A:Q227 4.52409
9A:A:W234 5.87409
10A:A:F238 5.986509
11A:A:F246 3.8475409
12A:A:S250 4.4825406
13A:A:S251 4.2254149
14A:A:W277 8.7225406
15A:A:Q294 5.66406
16A:A:L302 7.85754102
17A:A:F315 7.07506
18A:A:Y318 5.1975456
19A:A:P321 4.40754155
20A:A:D331 8.62754104
21A:A:Y339 5.07254153
22A:A:F340 8.22557
23A:A:R342 4.808504
24A:A:F345 6.84408
25A:A:Y360 5.134548
26A:A:T364 4.954599
27A:A:C365 2.7475408
28A:A:D368 4.155499
29A:A:R374 6.4625494
30A:A:F376 5.5425488
31B:B:H54 7.19529
32B:B:L55 7.4354116
33B:B:K57 8.1225439
34B:B:W63 3.574167
35B:B:D76 4.865409
36B:B:I80 6.02428
37B:B:W82 9.1675429
38B:B:K89 5.105429
39B:B:W99 7.192509
40B:B:Y105 3.12406
41B:B:Y124 4.2975406
42B:B:H142 6.814519
43B:B:Y145 3.928518
44B:B:L152 4.255403
45B:B:T159 4.99419
46B:B:D163 8.5725419
47B:B:W169 7.412518
48B:B:F180 5.094567
49B:B:H183 8.285409
50B:B:K209 8.9225466
51B:B:W211 7.698568
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:Q19 B:B:D83 12.35053.92YesNo748
2A:A:Q19 B:B:N88 14.0113.96YesNo747
3A:A:N23 B:B:N88 27.87169.54NoNo077
4A:A:N23 B:B:K89 30.26395.6NoYes079
5B:B:D76 B:B:S74 35.54792.94YesNo099
6B:B:H54 B:B:S74 35.36659.76YesNo099
7B:B:H54 B:B:I80 16.67856.63YesYes298
8B:B:I80 B:B:K89 15.52292.91YesYes289
9B:B:H54 B:B:W82 18.17593.17YesYes299
10B:B:K89 B:B:W82 16.19094.64YesYes299
11B:B:D76 B:B:L55 36.52312.21YesYes096
12A:A:Y37 B:B:L55 37.26677.03NoYes046
13A:A:R42 A:A:Y37 37.682315.43NoNo094
14A:A:F222 A:A:R42 38.10884.28YesNo079
15A:A:F222 B:B:W99 41.557316.04YesYes079
16A:A:F238 B:B:W99 47.64337.02YesYes099
17A:A:F238 A:A:L44 43.590512.18YesNo099
18A:A:L44 A:A:L46 42.81684.15NoNo098
19A:A:F246 A:A:L46 44.16923.65YesNo098
20A:A:F246 A:A:F273 52.42333.22YesNo099
21A:A:F273 A:A:F345 51.51747.5NoYes098
22A:A:F345 A:A:V248 1005.24YesNo087
23A:A:L291 A:A:V248 99.34022.98NoNo087
24A:A:L291 A:A:S250 40.24416.01NoYes086
25A:A:Q294 A:A:S250 35.76025.78YesYes066
26A:A:C365 A:A:Q294 68.94053.05YesYes086
27A:A:C365 A:A:D368 65.87564.67YesYes089
28A:A:D368 A:A:N371 27.40784.04YesNo999
29A:A:N371 A:A:Q59 27.426913.2NoNo099
30A:A:I372 A:A:Q59 26.3054.12NoNo089
31A:A:I372 A:A:V214 25.18144.61NoNo086
32A:A:F219 A:A:V214 14.89143.93YesNo886
33A:A:F246 A:A:L289 49.22443.65YesNo099
34A:A:F345 A:A:L289 49.15976.09YesNo089
35A:A:F363 A:A:L291 59.63756.09NoNo058
36A:A:F363 A:A:Q294 38.11527.03NoYes056
37A:A:F219 A:A:H41 11.54585.66YesNo086
38A:A:D368 A:A:T364 19.45454.34YesYes999
39A:A:N292 A:A:T364 17.03215.85NoYes099
40A:A:N292 A:A:V247 10.26812.96NoNo097
41A:A:W234 B:B:Y145 60.33922.89YesYes098
42A:A:R231 A:A:W234 56.91898NoYes099
43A:A:L272 A:A:R231 57.06844.86NoNo089
44A:A:D378 A:A:H362 16.5610.08NoNo079
45A:A:H362 A:A:R374 17.14516.77NoYes094
46A:A:D368 A:A:R374 18.76093.57YesYes994
47A:A:F363 A:A:R342 27.79784.28NoYes054
48A:A:D343 A:A:R342 16.78423.57NoYes034
49A:A:D343 A:A:Y318 15.61778.05NoYes036
50A:A:D378 A:A:Y360 13.04134.6NoYes078
51B:B:D83 B:B:R68 22.84114.29NoNo085
52B:B:D66 B:B:R68 10.65643.57NoNo085
53B:B:I93 B:B:V133 11.17037.68NoNo074
54B:B:I93 B:B:Y124 12.04894.84NoYes076
55B:B:H62 B:B:Y105 20.11883.27NoYes066
56B:B:H62 B:B:R150 19.53836.77NoNo066
57B:B:R68 B:B:Y85 11.804619.55NoNo054
58B:B:C114 B:B:L95 12.6653.17NoNo088
59B:B:C114 B:B:G115 13.9081.96NoNo089
60B:B:G115 B:B:T102 14.56781.82NoNo098
61B:B:C149 B:B:T102 14.90695.07NoNo088
62B:B:G109 B:B:Y105 19.78892.9NoYes056
63B:B:G109 B:B:S108 20.1071.86NoNo056
64B:B:N110 B:B:S108 20.81784.47NoNo046
65B:B:N110 B:B:Y111 21.54692.33NoNo044
66B:B:I123 B:B:Y111 22.31064.84NoNo064
67B:B:A113 B:B:C149 15.16391.81NoNo098
68B:B:A113 B:B:C121 17.53431.81NoNo098
69B:B:C121 B:B:L146 17.91613.17NoNo087
70B:B:I123 B:B:I171 23.11991.47NoNo066
71B:B:I157 B:B:I171 23.54181.47NoNo076
72B:B:H142 B:B:L146 17.79585.14YesNo197
73B:B:G162 B:B:Y145 51.54562.9NoYes198
74B:B:G162 B:B:S161 51.91473.71NoNo199
75B:B:H142 B:B:S161 50.137616.74YesNo199
76B:B:L192 B:B:R150 18.37183.64NoNo056
77B:B:L152 B:B:L192 17.78584.15YesNo035
78B:B:L152 B:B:V158 14.23162.98YesNo035
79B:B:L190 B:B:V158 13.63282.98NoNo055
80B:B:L190 B:B:S160 13.03223NoNo056
81B:B:S160 B:B:V187 11.82563.23NoNo069
82B:B:D83 B:B:T86 12.23575.78NoNo786
83B:B:N88 B:B:T86 13.06595.85NoNo776
84B:B:H142 B:B:T159 27.77785.48YesYes199
85B:B:I157 B:B:T159 23.20563.04NoYes179
86A:A:F246 A:A:L272 57.37464.87YesNo098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7Y3G
Class A
SubFamily Orphan
Type A orphans
SubType GPR12
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.77
Date 2023-06-07 
D.O.I. 10.1016/j.scib.2022.12.023
Net Summary
Imin 2.85
Number of Linked Nodes 394
Number of Links 429
Number of Hubs 51
Number of Links mediated by Hubs 187
Number of Communities 17
Number of Nodes involved in Communities 78
Number of Links involved in Communities 94
Path Summary
Number Of Nodes in MetaPath 87
Number Of Links MetaPath 86
Number of Shortest Paths 158749
Length Of Smallest Path 3
Average Path Length 22.9579
Length of Longest Path 48
Minimum Path Strength 1.14
Average Path Strength 5.53294
Maximum Path Strength 16.92
Minimum Path Correlation 0.7
Average Path Correlation 0.971544
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 56.4531
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.744
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7Y3G_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GGKNTIVKQ 
SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND VTAIIFVVA 
SSNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL AEKVLAGKI 
EDYFPEFAR YTTPEDATP EPGDPRVTR AKYFIRDEF LRISTASGD 
GRHYCYPHF TCAVDTENI RRVFNDCRD IIQRMHLRQ YELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7Y3G_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8G59ALipidFree fatty acidFFA4 (GPR120)Homo sapiensTUG-891-Gi1/&β;1/&γ;22.642023-03-0810.1126/science.add6220
8ID3ALipidFree fatty acidFFA4 (GPR120)Homo sapiens9-Hydroxystearic acid-Gi1/&β;1/&γ;23.12023-03-1510.1126/science.add6220
8ID4ALipidFree fatty acidFFA4 (GPR120)Homo sapiensLinoleic acid-Gi1/&β;1/&γ;23.12023-03-1510.1126/science.add6220
8ID6ALipidFree fatty acidFFA4 (GPR120)Homo sapiensOleic acid-Gi1/&β;1/&γ;22.82023-03-1510.1126/science.add6220
8ID8ALipidFree fatty acidFFA4 (GPR120)Homo sapiensTUG-891-Gi1/&β;1/&γ;232023-03-1510.1126/science.add6220
8ID9ALipidFree fatty acidFFA4 (GPR120)Homo sapiensEicosapentaenoic acid-Gi1/&β;1/&γ;232023-03-1510.1126/science.add6220
7Y3GAOrphanA orphansGPR12Homo sapiens--Gs/&β;1/&γ;22.772023-06-0710.1016/j.scib.2022.12.023




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y3G.zip



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