psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N45	R:R:V44	4.43	No	No	0	7	4
2	R:R:N45	R:R:W47	2.26	No	No	0	7	4
3	R:R:W47	R:R:Y284	12.54	No	No	0	4	4
4	R:R:D48	R:R:F101	4.78	No	Yes	0	4	6
5	R:R:F101	R:R:I49	3.77	Yes	No	0	6	7
6	R:R:L287	R:R:L51	2.77	No	No	0	5	4
7	R:R:C52	R:R:F101	6.98	No	Yes	0	4	6
8	R:R:G55	R:R:S54	1.86	Yes	No	0	6	5
9	R:R:S54	R:R:T291	4.8	No	No	0	5	6
10	R:R:G55	R:R:I58	3.53	Yes	Yes	1	6	7
11	R:R:G55	R:R:G94	2.11	Yes	Yes	1	6	8
12	R:R:G55	R:R:L97	5.13	Yes	No	1	6	7
13	R:R:I98	R:R:T56	7.6	No	No	0	6	5
14	R:R:I295	R:R:L57	4.28	Yes	No	0	6	5
15	R:R:I58	R:R:N62	4.25	Yes	Yes	1	7	9
16	R:R:D90	R:R:I58	4.2	Yes	Yes	1	9	7
17	R:R:I58	R:R:S294	7.74	Yes	No	1	7	9
18	R:R:I295	R:R:I58	4.42	Yes	Yes	1	6	7
19	R:R:G94	R:R:S59	1.86	Yes	No	0	8	5
20	R:R:I98	R:R:S59	3.1	No	No	0	6	5
21	R:R:E61	R:R:N62	2.63	No	Yes	1	7	9
22	R:R:E61	R:R:P298	4.72	No	Yes	1	7	9
23	R:R:N62	R:R:V65	2.96	Yes	No	0	9	9
24	R:R:D90	R:R:N62	13.46	Yes	Yes	1	9	9
25	R:R:L91	R:R:N62	4.12	No	Yes	0	7	9
26	R:R:N62	R:R:P298	6.52	Yes	Yes	1	9	9
27	R:R:A63	R:R:L91	4.73	No	No	0	4	7
28	R:R:F303	R:R:I64	2.51	No	No	0	5	7
29	R:R:L91	R:R:V66	4.47	No	No	0	7	7
30	R:R:I68	R:R:N72	2.83	No	Yes	4	8	6
31	R:R:I308	R:R:I68	4.42	Yes	No	0	8	8
32	R:R:A311	R:R:I68	3.25	No	No	4	7	8
33	R:R:F80	R:R:I69	2.51	Yes	No	0	8	7
34	R:R:I308	R:R:I69	2.94	Yes	No	0	8	7
35	R:R:H71	R:R:N72	16.58	No	Yes	0	5	6
36	R:R:N72	R:R:P73	3.26	Yes	No	0	6	5
37	R:R:A311	R:R:N72	3.13	No	Yes	4	7	6
38	R:R:F80	R:R:L75	8.53	Yes	No	0	8	8
39	R:R:A77	R:R:P78	1.87	No	No	0	7	5
40	R:R:A77	R:R:F80	2.77	No	Yes	0	7	8
41	R:R:P78	R:R:T153	8.74	No	No	0	5	8
42	R:R:P78	R:R:T157	6.99	No	No	0	5	6
43	R:R:F80	R:R:M79	7.46	Yes	No	0	8	8
44	R:R:F80	R:R:N305	2.42	Yes	No	0	8	8
45	R:R:L81	R:R:T157	2.95	No	No	0	4	6
46	R:R:L81	R:R:Y158	3.52	No	No	0	4	1
47	R:R:A133	R:R:L82	3.15	No	No	0	7	8
48	R:R:I134	R:R:L82	4.28	No	No	0	9	8
49	R:R:L161	R:R:L82	2.77	No	No	0	8	8
50	R:R:A87	R:R:G84	1.95	No	No	0	9	6
51	R:R:S85	R:R:W165	6.18	No	Yes	0	9	9
52	R:R:L86	R:R:S130	9.01	No	No	0	9	7
53	R:R:L86	R:R:N297	4.12	No	Yes	1	9	9
54	R:R:L86	R:R:Y301	2.34	No	Yes	1	9	9
55	R:R:L88	R:R:W165	2.28	No	Yes	0	6	9
56	R:R:A89	R:R:W165	2.59	No	Yes	0	8	9
57	R:R:D90	R:R:S294	10.31	Yes	No	1	9	9
58	R:R:D90	R:R:P298	3.22	Yes	Yes	1	9	9
59	R:R:L119	R:R:L92	8.3	No	No	0	4	7
60	R:R:L92	R:R:S123	3	No	Yes	0	7	6
61	R:R:A93	R:R:G94	1.95	No	Yes	0	8	8
62	R:R:A93	R:R:S123	3.42	No	Yes	0	8	6
63	R:R:G94	R:R:L97	3.42	Yes	No	1	8	7
64	R:R:G96	R:R:T99	3.64	No	No	0	4	7
65	R:R:F101	R:R:Y105	8.25	Yes	No	0	6	5
66	R:R:F103	R:R:V102	3.93	No	No	0	3	5
67	R:R:L106	R:R:Y105	10.55	No	No	0	5	5
68	R:R:E110	R:R:Q108	2.55	No	No	0	3	5
69	R:R:K113	R:R:T116	3	No	No	0	9	5
70	R:R:K113	R:R:V191	3.04	No	No	0	9	2
71	R:R:L114	R:R:R192	4.86	No	Yes	0	5	4
72	R:R:I117	R:R:R192	6.26	No	Yes	2	4	4
73	R:R:I117	R:R:P193	3.39	No	No	2	4	6
74	R:R:G118	R:R:V121	1.84	No	No	2	6	5
75	R:R:G118	R:R:G172	2.11	No	Yes	2	6	6
76	R:R:G118	R:R:P175	2.03	No	No	2	6	6
77	R:R:I120	R:R:S123	3.1	No	Yes	1	5	6
78	R:R:F124	R:R:I120	2.51	No	No	1	6	5
79	R:R:G172	R:R:V121	1.84	Yes	No	2	6	5
80	R:R:I201	R:R:V121	3.07	No	No	0	5	5
81	R:R:A122	R:R:G172	1.95	No	Yes	0	5	6
82	R:R:F124	R:R:S123	6.61	No	Yes	1	6	6
83	R:R:F124	R:R:W264	5.01	No	Yes	1	6	8
84	R:R:S125	R:R:S168	3.26	No	No	0	5	8
85	R:R:A126	R:R:W165	6.48	No	Yes	0	7	9
86	R:R:A126	R:R:S168	3.42	No	No	0	7	8
87	R:R:S127	R:R:V128	3.23	No	No	0	9	8
88	R:R:F260	R:R:V128	3.93	Yes	No	0	9	8
89	R:R:C129	R:R:L164	4.76	No	No	0	5	5
90	R:R:C129	R:R:M209	3.24	No	No	0	5	7
91	R:R:F260	R:R:L131	3.65	Yes	No	1	9	9
92	R:R:L131	R:R:N297	4.12	No	Yes	1	9	9
93	R:R:L131	R:R:Y301	4.69	No	Yes	1	9	9
94	R:R:L132	R:R:L212	2.77	No	No	0	6	5
95	R:R:I134	R:R:R138	5.01	No	No	0	9	9
96	R:R:M213	R:R:T135	4.52	Yes	No	1	8	8
97	R:R:L216	R:R:T135	4.42	No	No	0	6	8
98	R:R:T135	R:R:Y217	7.49	No	Yes	1	8	9
99	R:R:D137	R:R:Y148	2.3	No	No	0	9	8
100	R:R:R138	R:R:Y217	3.09	No	Yes	0	9	9
101	R:R:R138	R:R:Y301	2.06	No	Yes	0	9	9
102	R:R:Y139	R:R:Y143	7.94	No	No	0	7	6
103	R:R:L216	R:R:Y139	3.52	No	No	0	6	7
104	R:R:Q219	R:R:Y139	2.25	No	No	0	4	7
105	R:R:L140	R:R:Y144	2.34	No	No	0	6	5
106	R:R:S141	R:R:Y148	7.63	No	No	0	9	8
107	R:R:I220	R:R:L142	4.28	No	No	0	9	9
108	R:R:Y143	R:R:Y144	7.94	No	No	0	6	5
109	R:R:R152	R:R:T147	2.59	No	No	0	7	5
110	R:R:T153	R:R:Y148	7.49	No	No	0	8	8
111	R:R:E151	R:R:R152	11.63	No	No	0	4	7
112	R:R:V154	R:R:Y158	2.52	No	No	0	2	1
113	R:R:F156	R:R:M160	3.73	No	No	0	6	5
114	R:R:M163	R:R:T167	4.52	No	No	0	3	4
115	R:R:I169	R:R:L173	5.71	No	No	0	3	5
116	R:R:G172	R:R:P175	2.03	Yes	No	2	6	6
117	R:R:L174	R:R:W179	7.97	No	No	0	4	4
118	R:R:P175	R:R:R192	7.21	No	Yes	2	6	4
119	R:R:L194	R:R:W179	2.28	No	No	0	4	4
120	R:R:N197	R:R:W179	6.78	No	No	0	5	4
121	R:R:L182	R:R:N180	6.87	No	No	0	1	5
122	R:R:C181	R:R:C188	7.28	No	No	0	5	9
123	R:R:E185	R:R:R183	4.65	No	No	0	1	2
124	R:R:C188	R:R:D184	3.11	No	No	0	9	4
125	R:R:E185	R:R:T187	7.06	No	Yes	0	1	2
126	R:R:S186	R:R:Y276	10.17	No	No	0	4	4
127	R:R:L194	R:R:T187	5.9	No	Yes	0	4	2
128	R:R:T187	R:R:T195	3.14	Yes	No	0	2	3
129	R:R:S189	R:R:T195	3.2	No	No	0	4	3
130	R:R:N198	R:R:S189	2.98	No	No	0	6	4
131	R:R:P193	R:R:V190	3.53	No	No	0	6	5
132	R:R:P193	R:R:R192	14.41	No	Yes	2	6	4
133	R:R:K196	R:R:L194	4.23	No	No	0	7	4
134	R:R:I201	R:R:N197	2.83	No	No	0	5	5
135	R:R:L202	R:R:N198	5.49	Yes	No	5	6	6
136	R:R:N198	R:R:S271	10.43	No	No	5	6	5
137	R:R:L202	R:R:T268	5.9	Yes	No	0	6	6
138	R:R:L202	R:R:S271	9.01	Yes	No	5	6	5
139	R:R:L202	R:R:L272	6.92	Yes	No	0	6	6
140	R:R:F206	R:R:F210	20.36	Yes	Yes	1	8	7
141	R:R:F206	R:R:F260	9.65	Yes	Yes	1	8	9
142	R:R:F206	R:R:W264	7.02	Yes	Yes	1	8	8
143	R:R:F206	R:R:M265	6.22	Yes	No	0	8	5
144	R:R:F206	R:R:T268	5.19	Yes	No	0	8	6
145	R:R:F210	R:R:L214	2.44	Yes	No	0	7	5
146	R:R:F210	R:R:F260	4.29	Yes	Yes	1	7	9
147	R:R:A261	R:R:F210	4.16	No	Yes	0	5	7
148	R:R:M213	R:R:Y217	2.39	Yes	Yes	1	8	9
149	R:R:F260	R:R:M213	2.49	Yes	Yes	1	9	8
150	R:R:L214	R:R:L257	2.77	No	No	0	5	7
151	R:R:Q215	R:R:Q219	8.96	No	No	0	3	4
152	R:R:I220	R:R:Y217	2.42	No	Yes	0	9	9
153	R:R:L253	R:R:Y217	9.38	No	Yes	0	8	9
154	R:R:I256	R:R:Y217	2.42	No	Yes	0	8	9
155	R:R:L257	R:R:Y217	2.34	No	Yes	0	7	9
156	R:R:K222	R:R:Q219	6.78	No	No	0	4	4
157	R:R:C221	R:R:L253	4.76	No	No	0	6	8
158	R:R:H227	R:R:I223	2.65	No	No	0	7	6
159	R:R:Q230	R:R:R226	4.67	No	No	0	5	4
160	R:R:H229	R:R:L233	3.86	No	No	0	5	3
161	R:R:T246	R:R:V250	6.35	No	No	0	7	8
162	R:R:I256	R:R:T252	3.04	No	Yes	0	8	9
163	R:R:A261	R:R:G258	1.95	No	No	0	5	5
164	R:R:I296	R:R:T259	4.56	Yes	No	0	5	6
165	R:R:F260	R:R:W264	3.01	Yes	Yes	1	9	8
166	R:R:F260	R:R:N293	2.42	Yes	Yes	1	9	9
167	R:R:C263	R:R:P289	1.88	No	No	0	8	7
168	R:R:C263	R:R:N293	7.87	No	Yes	0	8	9
169	R:R:A290	R:R:W264	3.89	No	Yes	0	6	8
170	R:R:N293	R:R:W264	3.39	Yes	Yes	1	9	8
171	R:R:L269	R:R:M265	2.83	No	No	0	6	5
172	R:R:P266	R:R:T286	3.5	No	No	0	9	5
173	R:R:F267	R:R:S271	2.64	No	No	0	7	5
174	R:R:F267	R:R:L287	7.31	No	No	0	7	5
175	R:R:A274	R:R:Y270	6.67	No	Yes	3	4	4
176	R:R:Y270	R:R:Y278	4.96	Yes	Yes	3	4	3
177	R:R:Y270	R:R:Y282	4.96	Yes	Yes	3	4	4
178	R:R:T283	R:R:Y270	6.24	No	Yes	0	4	4
179	R:R:T286	R:R:Y270	13.73	No	Yes	0	5	4
180	R:R:A274	R:R:Y278	2.67	No	Yes	3	4	3
181	R:R:T277	R:R:Y276	8.74	No	No	0	3	4
182	R:R:P279	R:R:Y278	9.74	No	Yes	3	3	3
183	R:R:Y278	R:R:Y282	24.82	Yes	Yes	3	3	4
184	R:R:P279	R:R:Y282	8.34	No	Yes	3	3	4
185	R:R:I281	R:R:Y282	8.46	No	Yes	0	1	4
186	R:R:T283	R:R:Y284	8.74	No	No	0	4	4
187	R:R:I295	R:R:Y292	6.04	Yes	No	1	6	4
188	R:R:I296	R:R:Y292	2.42	Yes	No	1	5	4
189	R:R:I296	R:R:N293	2.83	Yes	Yes	1	5	9
190	R:R:N293	R:R:N297	5.45	Yes	Yes	1	9	9
191	R:R:I295	R:R:I296	4.42	Yes	Yes	1	6	5
192	R:R:I296	R:R:I300	2.94	Yes	No	0	5	8
193	R:R:N297	R:R:Y301	3.49	Yes	Yes	1	9	9
194	R:R:F303	R:R:P298	2.89	No	Yes	0	5	9
195	R:R:F303	R:R:V299	5.24	No	No	0	5	5
196	R:R:I300	R:R:Y301	3.63	No	Yes	0	8	9
197	R:R:E307	R:R:N305	6.57	No	No	0	7	8
198	R:R:I308	R:R:N305	5.66	Yes	No	0	8	8
199	R:R:Q306	R:R:Q309	10.24	No	No	0	5	8
200	R:R:K310	R:R:Q306	5.42	No	No	0	4	5
201	R:R:G249	R:R:T252	1.82	No	Yes	0	7	9
202	R:R:G96	R:R:I95	1.76	No	No	0	4	4
203	R:R:G166	R:R:I169	1.76	No	No	0	3	3
204	R:R:G178	R:R:M177	1.75	No	No	0	5	4
205	R:R:G249	R:R:K248	1.74	No	No	0	7	8
206	R:R:A89	R:R:S127	1.71	No	No	0	8	9
207	R:R:G96	R:R:L119	1.71	No	No	0	4	4
208	R:R:A87	R:R:V65	1.7	No	No	0	9	9
209	R:R:A302	R:R:V65	1.7	No	No	0	7	9
210	R:R:A87	R:R:V66	1.7	No	No	0	9	7
211	R:R:G178	R:R:N180	1.7	No	No	0	5	5
212	R:R:C181	R:R:T187	1.69	No	Yes	0	5	2
213	R:R:A111	R:R:T112	1.68	No	No	0	1	4
214	R:R:M265	R:R:P266	1.68	No	No	0	5	9
215	R:R:L288	R:R:P289	1.64	No	No	0	5	7
216	R:R:N45	R:R:P46	1.63	No	No	0	7	4
217	R:R:S54	R:R:V50	1.62	No	No	0	5	5
218	R:R:A302	R:R:I83	1.62	No	No	0	7	8
219	R:R:S205	R:R:V128	1.62	No	No	0	4	8
220	R:R:A302	R:R:I308	1.62	No	Yes	0	7	8
221	R:R:A133	R:R:M160	1.61	No	No	0	7	5
222	R:R:V190	R:R:V191	1.6	No	No	0	5	2
223	R:R:S251	R:R:T252	1.6	No	Yes	0	7	9
224	R:R:A126	R:R:L164	1.58	No	No	0	7	5
225	R:R:A104	R:R:N100	1.56	No	No	0	4	5
226	R:R:I98	R:R:V102	1.54	No	No	0	6	5
227	R:R:I220	R:R:V224	1.54	No	No	0	9	8
228	R:R:I49	R:R:T53	1.52	No	No	0	7	4
229	R:R:I255	R:R:T259	1.52	No	No	0	6	6
230	R:R:L140	R:R:V136	1.49	No	No	0	6	6
231	R:R:L216	R:R:V136	1.49	No	No	0	6	6
232	R:R:L173	R:R:V176	1.49	No	No	0	5	5
233	R:R:L146	R:R:T147	1.47	No	No	0	7	5
234	R:R:L207	R:R:T268	1.47	No	No	0	5	6
235	R:R:N100	R:R:T116	1.46	No	No	0	5	5
236	R:R:A232	R:R:H236	1.46	No	No	0	4	3
237	R:R:I218	R:R:K222	1.45	No	No	0	3	4
238	R:R:K222	R:R:M225	1.44	No	No	0	4	6
239	R:R:I223	R:R:L142	1.43	No	No	0	6	9
240	R:R:I201	R:R:L171	1.43	No	No	0	5	5
241	R:R:I273	R:R:L272	1.43	No	No	0	5	6
242	R:R:L132	R:R:M209	1.41	No	No	0	6	7
243	R:R:L132	R:R:M213	1.41	No	Yes	0	6	8
244	R:R:L106	R:R:L107	1.38	No	No	0	5	3
245	R:R:L114	R:R:N180	1.37	No	No	0	5	5
246	R:R:H235	R:R:I231	1.33	No	No	0	3	7
247	R:R:F103	R:R:T112	1.3	No	No	0	3	4
248	R:R:R152	R:R:T155	1.29	No	No	0	7	4
249	R:R:R304	R:R:T252	1.29	No	Yes	0	7	9
250	R:R:S280	R:R:Y284	1.27	No	No	0	1	4
251	R:R:E307	R:R:Q306	1.27	No	No	0	7	5
252	R:R:I223	R:R:R226	1.25	No	No	0	6	4
253	R:R:E151	R:R:H149	1.23	No	No	0	4	4
254	R:R:D275	R:R:Y276	1.15	No	No	0	3	4
255	R:R:D48	R:R:W47	1.12	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:G55	3.1575	4	1	6
2	R:R:I58	4.828	5	1	7
3	R:R:N62	5.65667	6	1	9
4	R:R:N72	6.45	4	4	6
5	R:R:F80	4.738	5	0	8
6	R:R:D90	7.7975	4	1	9
7	R:R:G94	2.335	4	1	8
8	R:R:F101	5.945	4	0	6
9	R:R:S123	4.0325	4	1	6
10	R:R:W165	4.3825	4	0	9
11	R:R:G172	1.9825	4	2	6
12	R:R:T187	4.4475	4	0	2
13	R:R:R192	8.185	4	2	4
14	R:R:L202	6.83	4	5	6
15	R:R:F206	9.688	5	1	8
16	R:R:F210	7.8125	4	1	7
17	R:R:M213	2.7025	4	1	8
18	R:R:Y217	4.21857	7	1	9
19	R:R:T252	1.9375	4	0	9
20	R:R:F260	4.20571	7	1	9
21	R:R:W264	4.464	5	1	8
22	R:R:Y270	7.312	5	3	4
23	R:R:Y278	10.5475	4	3	3
24	R:R:Y282	11.645	4	3	4
25	R:R:N293	4.392	5	1	9
26	R:R:I295	4.79	4	1	6
27	R:R:I296	3.434	5	1	5
28	R:R:N297	4.295	4	1	9
29	R:R:P298	4.3375	4	1	9
30	R:R:Y301	3.242	5	1	9
31	R:R:I308	3.66	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W47	R:R:Y284	22.0039	12.54	No	No	0	4	4
2	R:R:D48	R:R:W47	14.9438	1.12	No	No	0	4	4
3	R:R:D48	R:R:F101	13.1148	4.78	No	Yes	0	4	6
4	R:R:L202	R:R:T268	89.8841	5.9	Yes	No	0	6	6
5	R:R:F206	R:R:T268	92.3946	5.19	Yes	No	0	8	6
6	R:R:F206	R:R:M265	45.7798	6.22	Yes	No	0	8	5
7	R:R:M265	R:R:P266	42.5196	1.68	No	No	0	5	9
8	R:R:P266	R:R:T286	40.8724	3.5	No	No	0	9	5
9	R:R:T286	R:R:Y270	39.2139	13.73	No	Yes	0	5	4
10	R:R:T283	R:R:Y270	27.2862	6.24	No	Yes	0	4	4
11	R:R:T283	R:R:Y284	25.5367	8.74	No	No	0	4	4
12	R:R:G55	R:R:I58	15.188	3.53	Yes	Yes	1	6	7
13	R:R:I295	R:R:I58	98.1881	4.42	Yes	Yes	1	6	7
14	R:R:I295	R:R:I296	100	4.42	Yes	Yes	1	6	5
15	R:R:I296	R:R:N293	94.1327	2.83	Yes	Yes	1	5	9
16	R:R:F260	R:R:N293	60.2067	2.42	Yes	Yes	1	9	9
17	R:R:F206	R:R:F260	70.2601	9.65	Yes	Yes	1	8	9
18	R:R:N293	R:R:W264	40.117	3.39	Yes	Yes	1	9	8
19	R:R:F206	R:R:W264	49.6478	7.02	Yes	Yes	1	8	8
20	R:R:A93	R:R:G94	13.4897	1.95	No	Yes	0	8	8
21	R:R:A93	R:R:S123	14.1088	3.42	No	Yes	0	8	6
22	R:R:F124	R:R:S123	17.3634	6.61	No	Yes	1	6	6
23	R:R:F124	R:R:W264	19.3286	5.01	No	Yes	1	6	8
24	R:R:I58	R:R:N62	86.5671	4.25	Yes	Yes	1	7	9
25	R:R:N62	R:R:V65	73.9293	2.96	Yes	No	0	9	9
26	R:R:F303	R:R:P298	10.8827	2.89	No	Yes	0	5	9
27	R:R:A302	R:R:I308	66.5853	1.62	No	Yes	0	7	8
28	R:R:A302	R:R:V65	69.6637	1.7	No	No	0	7	9
29	R:R:F80	R:R:I69	23.2364	2.51	Yes	No	0	8	7
30	R:R:I308	R:R:I69	24.9631	2.94	Yes	No	0	8	7
31	R:R:F80	R:R:N305	23.5204	2.42	Yes	No	0	8	8
32	R:R:I308	R:R:N305	32.1652	5.66	Yes	No	0	8	8
33	R:R:A77	R:R:F80	35.9707	2.77	No	Yes	0	7	8
34	R:R:A77	R:R:P78	32.3696	1.87	No	No	0	7	5
35	R:R:P78	R:R:T153	14.1883	8.74	No	No	0	5	8
36	R:R:P78	R:R:T157	14.7393	6.99	No	No	0	5	6
37	R:R:L81	R:R:T157	11.0644	2.95	No	No	0	4	6
38	R:R:I134	R:R:L82	10.0704	4.28	No	No	0	9	8
39	R:R:I134	R:R:R138	12.0811	5.01	No	No	0	9	9
40	R:R:R138	R:R:Y217	13.6544	3.09	No	Yes	0	9	9
41	R:R:M213	R:R:Y217	23.4579	2.39	Yes	Yes	1	8	9
42	R:R:F260	R:R:M213	43.2125	2.49	Yes	Yes	1	9	8
43	R:R:R138	R:R:Y301	15.8525	2.06	No	Yes	0	9	9
44	R:R:F260	R:R:V128	13.0864	3.93	Yes	No	0	9	8
45	R:R:S127	R:R:V128	10.3828	3.23	No	No	0	9	8
46	R:R:K113	R:R:V191	13.6772	3.04	No	No	0	9	2
47	R:R:V190	R:R:V191	17.1873	1.6	No	No	0	5	2
48	R:R:P193	R:R:V190	20.6805	3.53	No	No	0	6	5
49	R:R:P193	R:R:R192	24.1281	14.41	No	Yes	2	6	4
50	R:R:P175	R:R:R192	48.0972	7.21	No	Yes	2	6	4
51	R:R:G118	R:R:P175	25.7639	2.03	No	No	2	6	6
52	R:R:G118	R:R:V121	27.4054	1.84	No	No	2	6	5
53	R:R:I201	R:R:V121	57.8666	3.07	No	No	0	5	5
54	R:R:I201	R:R:N197	60.8372	2.83	No	No	0	5	5
55	R:R:N197	R:R:W179	62.3367	6.78	No	No	0	5	4
56	R:R:L194	R:R:W179	65.3016	2.28	No	No	0	4	4
57	R:R:L194	R:R:T187	68.2211	5.9	No	Yes	0	4	2
58	R:R:T187	R:R:T195	76.7068	3.14	Yes	No	0	2	3
59	R:R:S189	R:R:T195	78.0813	3.2	No	No	0	4	3
60	R:R:N198	R:R:S189	79.4445	2.98	No	No	0	6	4
61	R:R:L202	R:R:N198	79.7001	5.49	Yes	No	5	6	6
62	R:R:G172	R:R:P175	25.7412	2.03	Yes	No	2	6	6
63	R:R:G172	R:R:V121	29.0242	1.84	Yes	No	2	6	5
64	R:R:K113	R:R:T116	10.3942	3	No	No	0	9	5
65	R:R:L114	R:R:R192	17.6076	4.86	No	Yes	0	5	4
66	R:R:M213	R:R:T135	14.9835	4.52	Yes	No	1	8	8
67	R:R:L216	R:R:T135	15.9434	4.42	No	No	0	6	8
68	R:R:T153	R:R:Y148	10.8088	7.49	No	No	0	8	8
69	R:R:L216	R:R:Y139	10.7463	3.52	No	No	0	6	7
70	R:R:I220	R:R:Y217	12.2515	2.42	No	Yes	0	9	9
71	R:R:L114	R:R:N180	14.1202	1.37	No	No	0	5	5
72	R:R:I256	R:R:Y217	10.4964	2.42	No	Yes	0	8	9
73	R:R:I296	R:R:I300	13.1432	2.94	Yes	No	0	5	8
74	R:R:I300	R:R:Y301	12.3992	3.63	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7Y3G_nogp

PDB Summary
PDB	7Y3G_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.84
Number of Linked Nodes	235
Number of Links	255
Number of Hubs	31
Number of Links mediated by Hubs	116
Number of Communities	5
Number of Nodes involved in Communities	45
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	38552
Length Of Smallest Path	3
Average Path Length	15.8954
Length of Longest Path	39
Minimum Path Strength	1.34
Average Path Strength	4.25688
Maximum Path Strength	16.64
Minimum Path Correlation	0.7
Average Path Correlation	0.930036
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	44.0893
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.8855
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cation binding • ion binding • binding • phosphatidylcholine binding • phospholipid binding • lipid binding • quaternary ammonium group binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • protein binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47775
Sequence	>7Y3G_nogp_Chain_R V N P W D I V L C T S G T L I S C E N A I V V L I I F H N P S L R A P M F L L I G S L A L A D L L A G I G L I T N F V F A Y L L Q S E A T K L V T I G L I V A S F S A S V C S L L A I T V D R Y L S L Y Y A L T Y H S E R T V T F T Y V M L V M L W G T S I C L G L L P V M G W N C L R D E S T C S V V R P L T K N N A A I L S V S F L F M F A L M L Q L Y I Q I C K I V M R H A H Q I A L Q H H F T R K G V S T L A I I L G T F A A C W M P F T L Y S L I A D Y T Y P S I Y T Y A T L L P A T Y N S I I N P V I Y A F R N Q E I Q K A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7Y3G	A	Orphan	Orphan	GPR12	Homo sapiens	-	-	Gs/β1/γ2	2.77	2023-06-07	doi.org/10.1016/j.scib.2022.12.023
	7Y3G (No Gprot)	A	Orphan	Orphan	GPR12	Homo sapiens	-	-		2.77	2023-06-07	doi.org/10.1016/j.scib.2022.12.023

there is no ligand in network 7Y3G_nogp

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.