psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H104	16.9	Yes	Yes	1	0	4
2	L:L:?1	R:R:L158	6.62	Yes	Yes	1	0	4
3	L:L:?1	R:R:H180	18.44	Yes	Yes	1	0	6
4	L:L:?1	R:R:Q181	14.32	Yes	Yes	1	0	4
5	L:L:?1	R:R:G198	8.18	Yes	No	0	0	4
6	L:L:?1	R:R:I202	10.24	Yes	No	0	0	4
7	L:L:?1	R:R:R262	11.62	Yes	Yes	1	0	4
8	R:R:C4	R:R:N5	3.15	No	No	0	4	8
9	R:R:C168	R:R:C4	7.28	No	No	0	9	4
10	R:R:F6	R:R:N5	10.87	No	No	0	3	8
11	R:R:F6	R:R:H8	6.79	No	No	0	3	3
12	R:R:C168	R:R:F6	4.19	No	No	0	9	3
13	R:R:H8	R:R:N171	12.75	No	No	0	3	6
14	R:R:F11	R:R:F93	5.36	Yes	No	1	9	3
15	R:R:C96	R:R:F11	4.19	No	Yes	1	9	9
16	R:R:F11	R:R:F167	8.57	Yes	Yes	1	9	7
17	R:R:F11	R:R:L186	3.65	Yes	No	0	9	7
18	R:R:R89	R:R:V12	5.23	No	No	0	5	7
19	R:R:L13	R:R:L83	4.15	No	No	0	8	6
20	R:R:I91	R:R:L13	4.28	Yes	No	0	9	8
21	R:R:I14	R:R:R89	3.76	No	No	0	5	5
22	R:R:I14	R:R:V172	3.07	No	No	0	5	3
23	R:R:F84	R:R:G15	3.01	Yes	No	0	4	9
24	R:R:G15	R:R:S176	3.71	No	No	0	9	6
25	R:R:I16	R:R:P17	3.39	Yes	Yes	0	6	7
26	R:R:H23	R:R:I16	3.98	No	Yes	5	6	6
27	R:R:I16	R:R:V26	3.07	Yes	No	5	6	6
28	R:R:F84	R:R:I16	6.28	Yes	Yes	5	4	6
29	R:R:P17	R:R:P269	3.9	Yes	No	0	7	3
30	R:R:P17	R:R:V273	7.07	Yes	No	0	7	6
31	R:R:A22	R:R:L19	3.15	No	No	0	4	3
32	R:R:E20	R:R:H23	11.08	No	No	0	5	6
33	R:R:A22	R:R:W25	5.19	No	No	0	4	3
34	R:R:F84	R:R:H23	15.84	Yes	No	5	4	6
35	R:R:F24	R:R:F28	7.5	No	No	0	2	4
36	R:R:F24	R:R:W85	8.02	No	Yes	0	2	5
37	R:R:F28	R:R:W25	4.01	No	No	0	4	3
38	R:R:F84	R:R:V26	6.55	Yes	No	5	4	6
39	R:R:L31	R:R:L81	4.15	No	No	3	5	8
40	R:R:L31	R:R:W85	9.11	No	Yes	3	5	5
41	R:R:M33	R:R:V285	3.04	No	No	0	5	5
42	R:R:M38	R:R:Y34	7.18	No	Yes	3	5	9
43	R:R:S73	R:R:Y34	6.36	Yes	Yes	3	7	9
44	R:R:M77	R:R:Y34	14.37	Yes	Yes	3	5	9
45	R:R:P78	R:R:Y34	5.56	No	Yes	0	9	9
46	R:R:L81	R:R:Y34	4.69	No	Yes	3	8	9
47	R:R:A37	R:R:S73	3.42	No	Yes	0	7	7
48	R:R:M38	R:R:S73	3.07	No	Yes	3	5	7
49	R:R:M38	R:R:T74	3.01	No	No	0	5	7
50	R:R:F39	R:R:I43	3.77	No	No	0	1	4
51	R:R:G40	R:R:P288	4.06	No	No	0	7	9
52	R:R:A66	R:R:N41	4.69	No	Yes	0	9	9
53	R:R:D69	R:R:N41	6.73	Yes	Yes	0	9	9
54	R:R:L70	R:R:N41	6.87	No	Yes	0	5	9
55	R:R:N41	R:R:P288	4.89	Yes	No	0	9	9
56	R:R:I298	R:R:V44	4.61	Yes	No	0	7	7
57	R:R:C63	R:R:V45	5.12	No	No	0	5	6
58	R:R:F46	R:R:T50	11.67	No	No	0	3	4
59	R:R:I298	R:R:I47	5.89	Yes	Yes	0	7	5
60	R:R:I47	R:R:R301	5.01	Yes	Yes	4	5	7
61	R:R:C63	R:R:V48	8.54	No	No	0	5	8
62	R:R:E51	R:R:R301	10.47	No	Yes	0	7	7
63	R:R:H55	R:R:R52	5.64	No	No	0	8	4
64	R:R:R301	R:R:S53	5.27	Yes	No	0	7	6
65	R:R:L54	R:R:Y59	11.72	No	Yes	4	9	9
66	R:R:L54	R:R:Q297	7.99	No	No	4	9	6
67	R:R:L54	R:R:R301	4.86	No	Yes	4	9	7
68	R:R:P57	R:R:T140	3.5	No	No	0	9	7
69	R:R:M58	R:R:Y59	8.38	No	Yes	0	9	9
70	R:R:Q297	R:R:Y59	5.64	No	Yes	4	6	9
71	R:R:L60	R:R:N137	5.49	No	No	0	7	2
72	R:R:A116	R:R:F61	5.55	No	Yes	0	5	8
73	R:R:F61	R:R:M117	3.73	Yes	No	0	8	9
74	R:R:D120	R:R:F61	7.17	No	Yes	0	9	8
75	R:R:F61	R:R:T140	7.78	Yes	No	0	8	7
76	R:R:F61	R:R:I143	3.77	Yes	No	0	8	6
77	R:R:G144	R:R:M64	3.49	No	No	0	5	7
78	R:R:I113	R:R:L65	4.28	No	No	0	6	9
79	R:R:L114	R:R:L65	4.15	No	No	0	9	9
80	R:R:L65	R:R:N287	6.87	No	Yes	0	9	9
81	R:R:I68	R:R:L106	4.28	Yes	No	0	5	4
82	R:R:I109	R:R:I68	4.42	No	Yes	0	5	5
83	R:R:E110	R:R:I68	4.1	Yes	Yes	0	8	5
84	R:R:I113	R:R:I68	4.42	No	Yes	0	6	5
85	R:R:D69	R:R:E110	9.09	Yes	Yes	2	9	8
86	R:R:D69	R:R:P284	3.22	Yes	No	0	9	9
87	R:R:D69	R:R:N287	8.08	Yes	Yes	2	9	9
88	R:R:A71	R:R:L106	4.73	No	No	0	4	4
89	R:R:L106	R:R:L72	4.15	No	No	0	4	4
90	R:R:L280	R:R:L72	4.15	Yes	No	0	7	4
91	R:R:M77	R:R:S73	6.13	Yes	Yes	3	5	7
92	R:R:M77	R:R:T76	3.01	Yes	No	0	5	6
93	R:R:L280	R:R:T76	5.9	Yes	No	0	7	6
94	R:R:K79	R:R:S88	3.06	No	No	0	6	1
95	R:R:I91	R:R:K79	4.36	Yes	No	0	9	6
96	R:R:I80	R:R:S176	7.74	No	No	0	6	6
97	R:R:L81	R:R:W85	3.42	No	Yes	3	8	5
98	R:R:F84	R:R:L83	4.87	Yes	No	0	4	6
99	R:R:F86	R:R:W85	11.02	No	Yes	0	5	5
100	R:R:C96	R:R:I91	3.27	No	Yes	1	9	9
101	R:R:C178	R:R:I91	3.27	No	Yes	1	9	9
102	R:R:F93	R:R:L97	10.96	No	No	0	3	4
103	R:R:F167	R:R:F93	5.36	Yes	No	1	7	3
104	R:R:E94	R:R:T98	4.23	No	No	0	1	4
105	R:R:C178	R:R:C96	7.28	No	No	1	9	9
106	R:R:Q99	R:R:Y177	3.38	No	Yes	0	9	5
107	R:R:C178	R:R:Q99	6.1	No	No	0	9	9
108	R:R:I162	R:R:M100	5.83	No	No	1	4	4
109	R:R:H180	R:R:M100	5.25	Yes	No	1	6	4
110	R:R:M100	R:R:V183	4.56	No	No	0	4	6
111	R:R:F101	R:R:F102	3.22	Yes	No	0	5	4
112	R:R:A105	R:R:F101	5.55	No	Yes	0	2	5
113	R:R:F101	R:R:F156	6.43	Yes	No	0	5	3
114	R:R:F101	R:R:P159	8.67	Yes	No	0	5	4
115	R:R:I103	R:R:V179	3.07	No	Yes	0	4	8
116	R:R:H104	R:R:L158	5.14	Yes	Yes	1	4	4
117	R:R:H104	R:R:V179	5.54	Yes	Yes	1	4	8
118	R:R:H104	R:R:Q181	7.42	Yes	Yes	1	4	4
119	R:R:S107	R:R:Y279	8.9	No	No	0	4	7
120	R:R:A108	R:R:F155	4.16	No	Yes	0	4	5
121	R:R:I109	R:R:V148	3.07	No	No	0	5	5
122	R:R:E110	R:R:F250	8.16	Yes	Yes	0	8	6
123	R:R:E110	R:R:N287	3.94	Yes	Yes	2	8	9
124	R:R:M206	R:R:S111	4.6	Yes	No	1	3	5
125	R:R:D209	R:R:S111	7.36	Yes	No	1	7	5
126	R:R:S111	R:R:Y251	7.63	No	Yes	1	5	6
127	R:R:A147	R:R:T112	3.36	No	No	0	6	3
128	R:R:R150	R:R:T112	5.17	No	No	0	3	3
129	R:R:A147	R:R:I113	3.25	No	No	0	6	6
130	R:R:L114	R:R:Y291	3.52	No	Yes	0	9	9
131	R:R:D209	R:R:L115	9.5	Yes	No	0	7	7
132	R:R:A118	R:R:I213	4.87	No	No	0	8	8
133	R:R:A118	R:R:S216	3.42	No	No	0	8	9
134	R:R:F119	R:R:V123	7.87	No	No	0	6	7
135	R:R:F119	R:R:L135	3.65	No	Yes	0	6	9
136	R:R:D120	R:R:H131	6.3	No	No	6	9	9
137	R:R:D120	R:R:L135	6.79	No	Yes	6	9	9
138	R:R:R121	R:R:Y217	12.35	Yes	No	2	9	9
139	R:R:I220	R:R:R121	5.01	Yes	Yes	0	9	9
140	R:R:H243	R:R:R121	3.39	Yes	Yes	2	9	9
141	R:R:C126	R:R:Y122	6.72	No	Yes	0	8	7
142	R:R:H127	R:R:Y122	11.98	No	Yes	0	4	7
143	R:R:S216	R:R:Y122	3.82	No	Yes	0	9	7
144	R:R:L219	R:R:Y122	8.21	No	Yes	0	2	7
145	R:R:A124	R:R:H131	8.78	No	No	0	9	9
146	R:R:I125	R:R:I220	7.36	No	Yes	0	9	9
147	R:R:I125	R:R:T223	3.04	No	No	0	9	6
148	R:R:C126	R:R:T223	6.76	No	No	0	8	6
149	R:R:H131	R:R:L135	5.14	No	Yes	6	9	9
150	R:R:N136	R:R:V139	4.43	No	No	0	7	4
151	R:R:I143	R:R:V139	3.07	No	No	0	6	4
152	R:R:R150	R:R:V205	9.15	No	Yes	0	3	4
153	R:R:D209	R:R:R150	9.53	Yes	No	0	7	3
154	R:R:F154	R:R:F155	3.22	No	Yes	1	4	5
155	R:R:F154	R:R:V205	9.18	No	Yes	1	4	4
156	R:R:F155	R:R:L158	8.53	Yes	Yes	1	5	4
157	R:R:F155	R:R:V205	3.93	Yes	Yes	1	5	4
158	R:R:F155	R:R:M206	3.73	Yes	Yes	1	5	3
159	R:R:F156	R:R:L160	6.09	No	No	0	3	2
160	R:R:P157	R:R:Y197	12.52	No	No	0	3	4
161	R:R:H180	R:R:L158	16.71	Yes	Yes	1	6	4
162	R:R:L158	R:R:Y197	3.52	Yes	No	0	4	4
163	R:R:L161	R:R:R164	4.86	No	No	0	4	5
164	R:R:L161	R:R:N194	4.12	No	Yes	0	4	6
165	R:R:L161	R:R:Y197	3.52	No	No	0	4	4
166	R:R:H180	R:R:I162	7.95	Yes	No	1	6	4
167	R:R:I162	R:R:N194	4.25	No	Yes	1	4	6
168	R:R:D190	R:R:R164	13.1	No	No	0	7	5
169	R:R:F167	R:R:L165	6.09	Yes	Yes	1	7	7
170	R:R:A187	R:R:L165	4.73	No	Yes	1	8	7
171	R:R:L165	R:R:N194	4.12	Yes	Yes	1	7	6
172	R:R:A187	R:R:F167	4.16	No	Yes	1	8	7
173	R:R:H169	R:R:Y188	8.71	No	No	0	4	9
174	R:R:L186	R:R:S170	4.5	No	No	0	7	6
175	R:R:D182	R:R:L173	9.5	Yes	No	0	6	8
176	R:R:L173	R:R:V183	5.96	No	No	0	8	6
177	R:R:L173	R:R:L186	4.15	No	No	0	8	7
178	R:R:R272	R:R:S174	9.22	Yes	No	0	6	5
179	R:R:H175	R:R:Y177	17.42	Yes	Yes	0	8	5
180	R:R:D182	R:R:H175	6.3	Yes	Yes	1	6	8
181	R:R:H175	R:R:L257	7.71	Yes	Yes	1	8	5
182	R:R:H175	R:R:H261	7.17	Yes	Yes	1	8	7
183	R:R:H175	R:R:R272	3.39	Yes	Yes	1	8	6
184	R:R:V179	R:R:Y177	3.79	Yes	Yes	0	8	5
185	R:R:L280	R:R:Y177	10.55	Yes	Yes	0	7	5
186	R:R:Q181	R:R:V179	10.03	Yes	Yes	1	4	8
187	R:R:D182	R:R:V179	5.84	Yes	Yes	1	6	8
188	R:R:H180	R:R:N194	8.93	Yes	Yes	1	6	6
189	R:R:H180	R:R:R262	3.39	Yes	Yes	1	6	4
190	R:R:L257	R:R:Q181	3.99	Yes	Yes	1	5	4
191	R:R:Q181	R:R:S258	4.33	Yes	No	0	4	7
192	R:R:H261	R:R:Q181	12.36	Yes	Yes	1	7	4
193	R:R:D182	R:R:H261	5.04	Yes	Yes	1	6	7
194	R:R:M184	R:R:V195	3.04	No	No	1	4	5
195	R:R:M184	R:R:R262	7.44	No	Yes	1	4	4
196	R:R:H261	R:R:K185	7.86	Yes	No	1	7	5
197	R:R:K185	R:R:N265	12.59	No	No	0	5	3
198	R:R:K185	R:R:R272	3.71	No	Yes	1	5	6
199	R:R:D190	R:R:P193	3.22	No	No	0	7	3
200	R:R:L192	R:R:P193	3.28	No	No	0	2	3
201	R:R:R262	R:R:V195	6.54	Yes	No	1	4	5
202	R:R:L199	R:R:L203	5.54	No	No	0	4	4
203	R:R:L199	R:R:R262	6.07	No	Yes	0	4	4
204	R:R:I202	R:R:M206	4.37	No	Yes	0	4	3
205	R:R:I202	R:R:S258	9.29	No	No	0	4	7
206	R:R:M206	R:R:V205	3.04	Yes	Yes	1	3	4
207	R:R:L254	R:R:M206	9.9	Yes	Yes	0	3	3
208	R:R:D209	R:R:Y251	5.75	Yes	Yes	1	7	6
209	R:R:V210	R:R:Y251	16.4	Yes	Yes	0	4	6
210	R:R:I213	R:R:V247	4.61	No	No	0	8	8
211	R:R:I213	R:R:Y251	3.63	No	Yes	0	8	6
212	R:R:L215	R:R:L219	4.15	No	No	0	3	2
213	R:R:H243	R:R:Y217	11.98	Yes	No	2	9	9
214	R:R:I244	R:R:Y217	7.25	No	No	0	7	9
215	R:R:F218	R:R:R222	7.48	No	No	0	2	3
216	R:R:L219	R:R:R222	4.86	No	No	0	2	3
217	R:R:F237	R:R:I221	7.54	No	No	0	7	5
218	R:R:C240	R:R:I221	4.91	No	No	0	9	5
219	R:R:A236	R:R:V224	5.09	No	No	0	9	8
220	R:R:F237	R:R:L225	3.65	No	No	0	7	7
221	R:R:L227	R:R:P228	3.28	No	No	0	7	4
222	R:R:E232	R:R:S229	8.62	No	No	0	7	9
223	R:R:K230	R:R:R233	4.95	No	No	0	4	7
224	R:R:F237	R:R:V241	3.93	No	No	0	7	5
225	R:R:H243	R:R:S242	4.18	Yes	No	2	9	9
226	R:R:K294	R:R:S242	3.06	Yes	No	2	9	9
227	R:R:H243	R:R:I290	6.63	Yes	Yes	2	9	9
228	R:R:H243	R:R:Y291	6.53	Yes	Yes	2	9	9
229	R:R:H243	R:R:K294	3.93	Yes	Yes	2	9	9
230	R:R:I286	R:R:V246	7.68	No	No	0	7	8
231	R:R:I290	R:R:V246	9.22	Yes	No	0	9	8
232	R:R:L248	R:R:V252	4.47	No	No	0	4	6
233	R:R:F250	R:R:Y251	13.41	Yes	Yes	0	6	6
234	R:R:F250	R:R:L254	3.65	Yes	Yes	0	6	3
235	R:R:F250	R:R:P283	5.78	Yes	No	0	6	8
236	R:R:P253	R:R:V252	3.53	No	No	0	6	6
237	R:R:I278	R:R:P253	6.77	No	No	0	5	6
238	R:R:L254	R:R:Y279	11.72	Yes	No	0	3	7
239	R:R:G256	R:R:M275	3.49	No	No	0	4	5
240	R:R:H261	R:R:L257	5.14	Yes	Yes	1	7	5
241	R:R:G276	R:R:L257	3.42	No	Yes	0	7	5
242	R:R:F263	R:R:V259	5.24	No	No	0	5	4
243	R:R:M275	R:R:V260	3.04	No	No	0	5	4
244	R:R:H261	R:R:R272	13.54	Yes	Yes	1	7	6
245	R:R:F263	R:R:R262	7.48	No	Yes	0	5	4
246	R:R:H268	R:R:P269	9.15	No	No	0	5	3
247	R:R:H268	R:R:I270	7.95	No	No	0	5	3
248	R:R:I270	R:R:V274	3.07	No	No	0	3	4
249	R:R:D277	R:R:L281	9.5	No	No	0	6	6
250	R:R:L280	R:R:Y279	14.07	Yes	No	0	7	7
251	R:R:I286	R:R:L282	7.14	No	No	0	7	5
252	R:R:P283	R:R:P284	5.84	No	No	0	8	9
253	R:R:N287	R:R:Y291	6.98	Yes	Yes	2	9	9
254	R:R:I290	R:R:Y291	15.71	Yes	Yes	2	9	9
255	R:R:I290	R:R:K294	4.36	Yes	Yes	2	9	9
256	R:R:G292	R:R:I298	3.53	No	Yes	0	8	7
257	R:R:I298	R:R:T295	6.08	Yes	No	0	7	9
258	R:R:K296	R:R:R299	3.71	No	No	0	6	7
259	R:R:Q297	R:R:R301	7.01	No	Yes	4	6	7
260	R:R:K294	R:R:T239	3	Yes	No	0	9	9
261	R:R:L135	R:R:V134	2.98	Yes	No	0	9	6
262	R:R:L267	R:R:V271	2.98	No	No	0	4	3
263	R:R:N171	R:R:V12	2.96	No	No	0	6	7
264	R:R:L60	R:R:T140	2.95	No	No	0	7	7
265	R:R:I43	R:R:I47	2.94	No	Yes	4	4	5
266	R:R:D277	R:R:V273	2.92	No	No	0	6	6
267	R:R:I244	R:R:L248	2.85	No	No	0	7	4
268	R:R:I255	R:R:L254	2.85	No	Yes	0	3	3
269	R:R:L30	R:R:M77	2.83	No	Yes	0	5	5
270	R:R:L62	R:R:M117	2.83	No	No	0	8	9
271	R:R:Q142	R:R:T138	2.83	No	No	0	2	4
272	R:R:E90	R:R:T10	2.82	No	No	0	4	5
273	R:R:E51	R:R:T50	2.82	No	No	0	7	4
274	R:R:K163	R:R:L97	2.82	No	No	0	3	4
275	R:R:G27	R:R:W85	2.81	No	Yes	0	8	5
276	R:R:A201	R:R:F155	2.77	No	Yes	0	3	5
277	R:R:A56	R:R:Y59	2.67	No	Yes	0	7	9
278	R:R:F101	R:R:S152	2.64	Yes	No	0	5	3
279	R:R:F212	R:R:V208	2.62	No	No	0	4	1
280	R:R:F102	R:R:T98	2.59	No	No	0	4	4
281	R:R:R301	R:R:T300	2.59	Yes	No	0	7	1
282	R:R:V48	R:R:Y59	2.52	No	Yes	0	8	9
283	R:R:M117	R:R:R121	2.48	No	Yes	0	9	9
284	R:R:F212	R:R:L215	2.44	No	No	0	4	3
285	R:R:L83	R:R:R89	2.43	No	No	0	6	5
286	R:R:L225	R:R:R233	2.43	No	No	0	7	7
287	R:R:L62	R:R:Y59	2.34	No	Yes	0	8	9
288	R:R:H127	R:R:R130	2.26	No	No	0	4	6
289	R:R:G18	R:R:P17	2.03	No	Yes	0	4	7
290	R:R:A108	R:R:G151	1.95	No	No	0	4	6
291	R:R:A147	R:R:G144	1.95	No	No	0	6	5
292	R:R:G207	R:R:V210	1.84	No	Yes	0	2	4
293	R:R:G256	R:R:V259	1.84	No	No	0	4	4
294	R:R:G264	R:R:V260	1.84	No	No	0	4	4
295	R:R:A166	R:R:C4	1.81	No	No	0	5	4
296	R:R:A82	R:R:S88	1.71	No	No	0	3	1
297	R:R:A95	R:R:S92	1.71	No	No	0	5	8
298	R:R:A37	R:R:V285	1.7	No	No	0	7	5
299	R:R:A166	R:R:T7	1.68	No	No	0	5	4
300	R:R:L158	R:R:P159	1.64	Yes	No	0	4	4
301	R:R:C240	R:R:I220	1.64	No	Yes	0	9	9
302	R:R:A95	R:R:I91	1.62	No	Yes	0	5	9
303	R:R:S214	R:R:V210	1.62	No	Yes	0	3	4
304	R:R:A249	R:R:I286	1.62	No	No	0	5	7
305	R:R:V285	R:R:V36	1.6	No	No	0	5	3
306	R:R:I103	R:R:S75	1.55	No	No	0	4	5
307	R:R:I43	R:R:V302	1.54	No	No	4	4	6
308	R:R:I47	R:R:V302	1.54	Yes	No	4	5	6
309	R:R:I145	R:R:V149	1.54	No	No	0	3	2
310	R:R:I220	R:R:V224	1.54	Yes	No	0	9	8
311	R:R:H127	R:R:P128	1.53	No	No	0	4	9
312	R:R:M211	R:R:V210	1.52	No	Yes	0	3	4
313	R:R:M275	R:R:V271	1.52	No	No	0	5	3
314	R:R:K235	R:R:T239	1.5	No	No	0	9	9
315	R:R:L192	R:R:V196	1.49	No	No	0	2	2
316	R:R:L227	R:R:V224	1.49	No	No	0	7	8
317	R:R:L165	R:R:T191	1.47	Yes	No	0	7	7
318	R:R:C168	R:R:H169	1.47	No	No	0	9	4
319	R:R:L204	R:R:T200	1.47	No	No	0	3	4
320	R:R:I289	R:R:I290	1.47	No	Yes	0	6	9
321	R:R:N136	R:R:T138	1.46	No	No	0	7	4
322	R:R:F28	R:R:P29	1.44	No	No	0	4	3
323	R:R:E90	R:R:V12	1.43	No	No	0	4	7
324	R:R:C63	R:R:R49	1.39	No	No	0	5	1
325	R:R:E232	R:R:L227	1.33	No	No	0	7	7
326	R:R:H55	R:R:L60	1.29	No	No	0	8	7
327	R:R:F46	R:R:M305	1.24	No	No	0	3	4
328	R:R:L129	R:R:R130	1.21	No	No	0	9	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.3314	7	1	0
2	R:R:F11	5.4425	4	1	9
3	R:R:I16	4.18	4	5	6
4	R:R:P17	4.0975	4	0	7
5	R:R:Y34	7.632	5	3	9
6	R:R:N41	5.795	4	0	9
7	R:R:I47	3.845	4	4	5
8	R:R:Y59	5.545	6	4	9
9	R:R:F61	5.6	5	0	8
10	R:R:I68	4.305	4	0	5
11	R:R:D69	6.78	4	2	9
12	R:R:S73	4.745	4	3	7
13	R:R:M77	6.585	4	3	5
14	R:R:F84	7.31	5	5	4
15	R:R:W85	6.876	5	3	5
16	R:R:I91	3.36	5	1	9
17	R:R:F101	5.302	5	0	5
18	R:R:H104	8.75	4	1	4
19	R:R:E110	6.3225	4	2	8
20	R:R:R121	5.8075	4	2	9
21	R:R:Y122	7.6825	4	0	7
22	R:R:L135	4.64	4	6	9
23	R:R:F155	4.39	6	1	5
24	R:R:L158	7.02667	6	1	4
25	R:R:L165	4.1025	4	1	7
26	R:R:F167	6.045	4	1	7
27	R:R:H175	8.398	5	1	8
28	R:R:Y177	8.785	4	0	5
29	R:R:V179	5.654	5	1	8
30	R:R:H180	10.1117	6	1	6
31	R:R:Q181	8.74167	6	1	4
32	R:R:D182	6.67	4	1	6
33	R:R:N194	5.355	4	1	6
34	R:R:V205	6.325	4	1	4
35	R:R:M206	5.128	5	1	3
36	R:R:D209	8.035	4	1	7
37	R:R:V210	5.345	4	0	4
38	R:R:I220	3.8875	4	0	9
39	R:R:H243	6.10667	6	2	9
40	R:R:F250	7.75	4	0	6
41	R:R:Y251	9.364	5	1	6
42	R:R:L254	7.03	4	0	3
43	R:R:L257	5.065	4	1	5
44	R:R:H261	8.51833	6	1	7
45	R:R:R262	7.09	6	1	4
46	R:R:R272	7.465	4	1	6
47	R:R:L280	8.6675	4	0	7
48	R:R:N287	6.4675	4	2	9
49	R:R:I290	7.478	5	2	9
50	R:R:Y291	8.185	4	2	9
51	R:R:K294	3.5875	4	2	9
52	R:R:I298	5.0275	4	0	7
53	R:R:R301	5.86833	6	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H104	R:R:V179	12.4663	5.54	Yes	Yes	1	4	8
2	R:R:V179	R:R:Y177	22.1277	3.79	Yes	Yes	0	8	5
3	R:R:Q99	R:R:Y177	58.4683	3.38	No	Yes	0	9	5
4	R:R:C178	R:R:Q99	57.5658	6.1	No	No	0	9	9
5	R:R:C178	R:R:I91	51.6833	3.27	No	Yes	1	9	9
6	R:R:I91	R:R:L13	50.125	4.28	Yes	No	0	9	8
7	R:R:L13	R:R:L83	48.9206	4.15	No	No	0	8	6
8	R:R:L83	R:R:R89	26.3351	2.43	No	No	0	6	5
9	R:R:R89	R:R:V12	22.3322	5.23	No	No	0	5	7
10	R:R:N171	R:R:V12	18.2709	2.96	No	No	0	6	7
11	R:R:H8	R:R:N171	16.9042	12.75	No	No	0	3	6
12	R:R:F6	R:R:H8	15.531	6.79	No	No	0	3	3
13	L:L:?1	R:R:Q181	10.697	14.32	Yes	Yes	1	0	4
14	R:R:H180	R:R:N194	12.5637	8.93	Yes	Yes	1	6	6
15	R:R:L165	R:R:N194	12.2748	4.12	Yes	Yes	1	7	6
16	R:R:F84	R:R:L83	23.4685	4.87	Yes	No	0	4	6
17	R:R:F84	R:R:I16	13.8461	6.28	Yes	Yes	5	4	6
18	R:R:I16	R:R:P17	12.7001	3.39	Yes	Yes	0	6	7
19	R:R:L280	R:R:Y177	72.9929	10.55	Yes	Yes	0	7	5
20	R:R:L280	R:R:T76	34.1655	5.9	Yes	No	0	7	6
21	R:R:M77	R:R:T76	32.8767	3.01	Yes	No	0	5	6
22	R:R:M77	R:R:Y34	20.6441	14.37	Yes	Yes	3	5	9
23	R:R:L81	R:R:Y34	15.4563	4.69	No	Yes	3	8	9
24	R:R:L81	R:R:W85	12.6773	3.42	No	Yes	3	8	5
25	L:L:?1	R:R:I202	18.7612	10.24	Yes	No	0	0	4
26	R:R:I202	R:R:M206	23.0562	4.37	No	Yes	0	4	3
27	R:R:L254	R:R:M206	32.7403	9.9	Yes	Yes	0	3	3
28	R:R:F250	R:R:L254	72.4702	3.65	Yes	Yes	0	6	3
29	R:R:E110	R:R:F250	69.042	8.16	Yes	Yes	0	8	6
30	R:R:E110	R:R:N287	96.3997	3.94	Yes	Yes	2	8	9
31	R:R:N287	R:R:Y291	100	6.98	Yes	Yes	2	9	9
32	R:R:H243	R:R:Y291	92.0397	6.53	Yes	Yes	2	9	9
33	R:R:H243	R:R:R121	83.7126	3.39	Yes	Yes	2	9	9
34	R:R:M117	R:R:R121	73.2948	2.48	No	Yes	0	9	9
35	R:R:L62	R:R:M117	51.0307	2.83	No	No	0	8	9
36	R:R:L62	R:R:Y59	50.0373	2.34	No	Yes	0	8	9
37	R:R:L54	R:R:Y59	20.8584	11.72	No	Yes	4	9	9
38	R:R:L54	R:R:R301	19.5858	4.86	No	Yes	4	9	7
39	R:R:I47	R:R:R301	21.2674	5.01	Yes	Yes	4	5	7
40	R:R:Q297	R:R:Y59	20.8519	5.64	No	Yes	4	6	9
41	R:R:Q297	R:R:R301	19.7611	7.01	No	Yes	4	6	7
42	R:R:I298	R:R:I47	10.684	5.89	Yes	Yes	0	7	5
43	R:R:E51	R:R:R301	10.671	10.47	No	Yes	0	7	7
44	R:R:F61	R:R:M117	26.5461	3.73	Yes	No	0	8	9
45	R:R:F155	R:R:L158	20.4136	8.53	Yes	Yes	1	5	4
46	R:R:E110	R:R:I68	37.084	4.1	Yes	Yes	0	8	5
47	R:R:L280	R:R:L72	38.6683	4.15	Yes	No	0	7	4
48	R:R:L106	R:R:L72	38.4346	4.15	No	No	0	4	4
49	R:R:L254	R:R:Y279	45.6741	11.72	Yes	No	0	3	7
50	R:R:M206	R:R:S111	11.408	4.6	Yes	No	1	3	5
51	R:R:I213	R:R:Y251	14.8524	3.63	No	Yes	0	8	6
52	R:R:A118	R:R:I213	12.8656	4.87	No	No	0	8	8
53	R:R:A118	R:R:S216	12.265	3.42	No	No	0	8	9
54	R:R:I220	R:R:R121	23.1374	5.01	Yes	Yes	0	9	9
55	R:R:S216	R:R:Y122	11.7391	3.82	No	Yes	0	9	7
56	L:L:?1	R:R:R262	14.8038	11.62	Yes	Yes	1	0	4
57	R:R:F263	R:R:R262	11.7099	7.48	No	Yes	0	5	4
58	R:R:F263	R:R:V259	10.2685	5.24	No	No	0	5	4
59	R:R:F155	R:R:M206	18.1573	3.73	Yes	Yes	1	5	3
60	R:R:I68	R:R:L106	38.2268	4.28	Yes	No	0	5	4
61	R:R:L280	R:R:Y279	45.0573	14.07	Yes	No	0	7	7
62	R:R:H175	R:R:Y177	13.6415	17.42	Yes	Yes	0	8	5
63	R:R:F250	R:R:Y251	12.2034	13.41	Yes	Yes	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H104	16.9	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L158	6.62	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:H180	18.44	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q181	14.32	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:G198	8.18	1	Yes	No	0	4	0	1
L:L:?1	R:R:I202	10.24	1	Yes	No	0	4	0	1
L:L:?1	R:R:R262	11.62	1	Yes	Yes	0	4	0	1
R:R:I162	R:R:M100	5.83	1	No	No	4	4	2	2
R:R:H180	R:R:M100	5.25	1	Yes	No	6	4	1	2
R:R:H104	R:R:L158	5.14	1	Yes	Yes	4	4	1	1
R:R:H104	R:R:V179	5.54	1	Yes	Yes	4	8	1	2
R:R:H104	R:R:Q181	7.42	1	Yes	Yes	4	4	1	1
R:R:F155	R:R:L158	8.53	1	Yes	Yes	5	4	2	1
R:R:F155	R:R:M206	3.73	1	Yes	Yes	5	3	2	2
R:R:H180	R:R:L158	16.71	1	Yes	Yes	6	4	1	1
R:R:L158	R:R:Y197	3.52	1	Yes	No	4	4	1	2
R:R:H180	R:R:I162	7.95	1	Yes	No	6	4	1	2
R:R:I162	R:R:N194	4.25	1	No	Yes	4	6	2	2
R:R:Q181	R:R:V179	10.03	1	Yes	Yes	4	8	1	2
R:R:H180	R:R:N194	8.93	1	Yes	Yes	6	6	1	2
R:R:H180	R:R:R262	3.39	1	Yes	Yes	6	4	1	1
R:R:L257	R:R:Q181	3.99	1	Yes	Yes	5	4	2	1
R:R:Q181	R:R:S258	4.33	1	Yes	No	4	7	1	2
R:R:H261	R:R:Q181	12.36	1	Yes	Yes	7	4	2	1
R:R:M184	R:R:V195	3.04	1	No	No	4	5	2	2
R:R:M184	R:R:R262	7.44	1	No	Yes	4	4	2	1
R:R:R262	R:R:V195	6.54	1	Yes	No	4	5	1	2
R:R:L199	R:R:R262	6.07	0	No	Yes	4	4	2	1
R:R:I202	R:R:M206	4.37	0	No	Yes	4	3	1	2
R:R:I202	R:R:S258	9.29	0	No	No	4	7	1	2
R:R:H261	R:R:L257	5.14	1	Yes	Yes	7	5	2	2
R:R:F263	R:R:R262	7.48	0	No	Yes	5	4	2	1
R:R:L158	R:R:P159	1.64	1	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F76_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	281
Number of Links	328
Number of Hubs	53
Number of Links mediated by Hubs	186
Number of Communities	6
Number of Nodes involved in Communities	64
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	64600
Length Of Smallest Path	3
Average Path Length	14.6477
Length of Longest Path	33
Minimum Path Strength	1.41
Average Path Strength	5.95355
Maximum Path Strength	17.67
Minimum Path Correlation	0.7
Average Path Correlation	0.914241
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	41.7617
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.7845
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell population proliferation • epithelial cell proliferation • melanocyte proliferation • protein localization • regulation of systemic arterial blood pressure by renin-angiotensin • multicellular organismal process • regulation of localization • regulation of systemic arterial blood pressure by hormone • system process • establishment of protein localization • nitrogen compound transport • regulation of renal system process • regulation of system process • positive regulation of establishment of protein localization • localization • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • cellular macromolecule localization • regulation of biological quality • establishment of protein localization to extracellular region • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • positive regulation of renin secretion into blood stream • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • regulation of endocrine process • renin secretion into blood stream • cellular localization • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • protein localization to extracellular region • positive regulation of protein transport • regulation of secretion by cell • secretion by cell • regulation of renin secretion into blood stream • positive regulation of secretion • signal release • regulation of multicellular organismal process • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • positive regulation of cellular process • renal system process • regulation of transport • secretion • regulation of blood pressure • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • regulation of systemic arterial blood pressure • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • developmental process • pigment cell differentiation • pigmentation • cellular developmental process • cell differentiation • developmental pigmentation • melanocyte differentiation • positive regulation of blood pressure • response to lipid • response to endogenous stimulus • hormone-mediated signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • response to steroid hormone • cellular response to lipid • cellular response to steroid hormone stimulus • steroid hormone receptor signaling pathway • cellular response to hormone stimulus • response to fatty acid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to fatty acid • cell migration • cell motility • intracellular organelle • cellular anatomical structure • intracellular anatomical structure • organelle • membrane-bounded organelle • endosome membrane • early endosome • endosome • membrane • intracellular vesicle • early endosome membrane • intracellular membrane-bounded organelle • endomembrane system • cytoplasmic vesicle membrane
Gene Ontology	Cellular Component	• intracellular organelle • cellular anatomical structure • intracellular anatomical structure • organelle • membrane-bounded organelle • endosome membrane • early endosome • endosome • membrane • intracellular vesicle • early endosome membrane • intracellular membrane-bounded organelle • endomembrane system • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • cytoplasm • vesicle • organelle membrane • cell periphery • plasma membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PPI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PPI
Name	Propanoic acid
Synonyms	Sodium propionate Propanoic acid Propionic acid
Identifier
Formula	C3 H6 O2
Molecular Weight	74.079
SMILES
PubChem	1032
Formal Charge	0
Total Atoms	11
Total Chiral Atoms	0
Total Bonds	10
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H255
Sequence	>8F76_nogp_Chain_R C N F T H A T F V L I G I P G L E K A H F W V G F P L L S M Y V V A M F G N C I V V F I V R T E R S L H A P M Y L F L C M L A A I D L A L S T S T M P K I L A L F W F D S R E I S F E A C L T Q M F F I H A L S A I E S T I L L A M A F D R Y V A I C H P L R H A A V L N N T V T A Q I G I V A V V R G S L F F F P L P L L I K R L A F C H S N V L S H S Y C V H Q D V M K L A Y A D T L P N V V Y G L T A I L L V M G V D V M F I S L S Y F L I I R T V L Q L P S K S E R A K A F G T C V S H I G V V L A F Y V P L I G L S V V H R F G N S L H P I V R V V M G D I Y L L L P P V I N P I I Y G A K T K Q I R T R V L A M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8F76	O1	Odorant receptors	Odorant family 51	OR51E2	Homo sapiens	Propanoic acid	-	Gs/β1/γ2	3.1	2023-03-22	10.1038/s41586-023-05798-y
	8F76 (No Gprot)	O1	Odorant receptors	Odorant family 51	OR51E2	Homo sapiens	Propanoic acid	-		3.1	2023-03-22	10.1038/s41586-023-05798-y

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