psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H104	16.9	Yes	Yes	1	0	4
2	L:L:?1	R:R:L158	6.62	Yes	Yes	1	0	4
3	L:L:?1	R:R:H180	18.44	Yes	Yes	1	0	6
4	L:L:?1	R:R:Q181	14.32	Yes	Yes	1	0	4
5	L:L:?1	R:R:G198	8.18	Yes	No	0	0	4
6	L:L:?1	R:R:I202	10.24	Yes	No	0	0	4
7	L:L:?1	R:R:R262	11.62	Yes	Yes	1	0	4
8	R:R:C4	R:R:N5	3.15	No	No	0	4	8
9	R:R:C168	R:R:C4	7.28	No	No	0	9	4
10	R:R:F6	R:R:N5	10.87	No	No	0	3	8
11	R:R:F6	R:R:H8	6.79	No	No	0	3	3
12	R:R:C168	R:R:F6	4.19	No	No	0	9	3
13	R:R:H8	R:R:N171	12.75	No	No	0	3	6
14	R:R:F11	R:R:F93	5.36	Yes	No	1	9	3
15	R:R:C96	R:R:F11	4.19	No	Yes	1	9	9
16	R:R:F11	R:R:F167	8.57	Yes	Yes	1	9	7
17	R:R:F11	R:R:L186	3.65	Yes	No	0	9	7
18	R:R:R89	R:R:V12	5.23	No	No	0	5	7
19	R:R:L13	R:R:L83	4.15	No	No	0	8	6
20	R:R:I91	R:R:L13	4.28	Yes	No	0	9	8
21	R:R:I14	R:R:R89	3.76	No	No	0	5	5
22	R:R:I14	R:R:V172	3.07	No	No	0	5	3
23	R:R:F84	R:R:G15	3.01	Yes	No	0	4	9
24	R:R:G15	R:R:S176	3.71	No	No	0	9	6
25	R:R:I16	R:R:P17	3.39	Yes	Yes	0	6	7
26	R:R:H23	R:R:I16	3.98	No	Yes	5	6	6
27	R:R:I16	R:R:V26	3.07	Yes	No	5	6	6
28	R:R:F84	R:R:I16	6.28	Yes	Yes	5	4	6
29	R:R:P17	R:R:P269	3.9	Yes	No	0	7	3
30	R:R:P17	R:R:V273	7.07	Yes	No	0	7	6
31	R:R:A22	R:R:L19	3.15	No	No	0	4	3
32	R:R:E20	R:R:H23	11.08	No	No	0	5	6
33	R:R:A22	R:R:W25	5.19	No	No	0	4	3
34	R:R:F84	R:R:H23	15.84	Yes	No	5	4	6
35	R:R:F24	R:R:F28	7.5	No	No	0	2	4
36	R:R:F24	R:R:W85	8.02	No	Yes	0	2	5
37	R:R:F28	R:R:W25	4.01	No	No	0	4	3
38	R:R:F84	R:R:V26	6.55	Yes	No	5	4	6
39	R:R:L31	R:R:L81	4.15	No	No	3	5	8
40	R:R:L31	R:R:W85	9.11	No	Yes	3	5	5
41	R:R:M33	R:R:V285	3.04	No	No	0	5	5
42	R:R:M38	R:R:Y34	7.18	No	Yes	3	5	9
43	R:R:S73	R:R:Y34	6.36	Yes	Yes	3	7	9
44	R:R:M77	R:R:Y34	14.37	Yes	Yes	3	5	9
45	R:R:P78	R:R:Y34	5.56	No	Yes	0	9	9
46	R:R:L81	R:R:Y34	4.69	No	Yes	3	8	9
47	R:R:A37	R:R:S73	3.42	No	Yes	0	7	7
48	R:R:M38	R:R:S73	3.07	No	Yes	3	5	7
49	R:R:M38	R:R:T74	3.01	No	No	0	5	7
50	R:R:F39	R:R:I43	3.77	No	No	0	1	4
51	R:R:G40	R:R:P288	4.06	No	No	0	7	9
52	R:R:A66	R:R:N41	4.69	No	Yes	0	9	9
53	R:R:D69	R:R:N41	6.73	Yes	Yes	0	9	9
54	R:R:L70	R:R:N41	6.87	No	Yes	0	5	9
55	R:R:N41	R:R:P288	4.89	Yes	No	0	9	9
56	R:R:I298	R:R:V44	4.61	Yes	No	0	7	7
57	R:R:C63	R:R:V45	5.12	No	No	0	5	6
58	R:R:F46	R:R:T50	11.67	No	No	0	3	4
59	R:R:I298	R:R:I47	5.89	Yes	Yes	0	7	5
60	R:R:I47	R:R:R301	5.01	Yes	Yes	4	5	7
61	R:R:C63	R:R:V48	8.54	No	No	0	5	8
62	R:R:E51	R:R:R301	10.47	No	Yes	0	7	7
63	R:R:H55	R:R:R52	5.64	No	No	0	8	4
64	R:R:R301	R:R:S53	5.27	Yes	No	0	7	6
65	R:R:L54	R:R:Y59	11.72	No	Yes	4	9	9
66	R:R:L54	R:R:Q297	7.99	No	No	4	9	6
67	R:R:L54	R:R:R301	4.86	No	Yes	4	9	7
68	R:R:P57	R:R:T140	3.5	No	No	0	9	7
69	R:R:M58	R:R:Y59	8.38	No	Yes	0	9	9
70	R:R:Q297	R:R:Y59	5.64	No	Yes	4	6	9
71	R:R:L60	R:R:N137	5.49	No	No	0	7	2
72	R:R:A116	R:R:F61	5.55	No	Yes	0	5	8
73	R:R:F61	R:R:M117	3.73	Yes	No	0	8	9
74	R:R:D120	R:R:F61	7.17	No	Yes	0	9	8
75	R:R:F61	R:R:T140	7.78	Yes	No	0	8	7
76	R:R:F61	R:R:I143	3.77	Yes	No	0	8	6
77	R:R:G144	R:R:M64	3.49	No	No	0	5	7
78	R:R:I113	R:R:L65	4.28	No	No	0	6	9
79	R:R:L114	R:R:L65	4.15	No	No	0	9	9
80	R:R:L65	R:R:N287	6.87	No	Yes	0	9	9
81	R:R:I68	R:R:L106	4.28	Yes	No	0	5	4
82	R:R:I109	R:R:I68	4.42	No	Yes	0	5	5
83	R:R:E110	R:R:I68	4.1	Yes	Yes	0	8	5
84	R:R:I113	R:R:I68	4.42	No	Yes	0	6	5
85	R:R:D69	R:R:E110	9.09	Yes	Yes	2	9	8
86	R:R:D69	R:R:P284	3.22	Yes	No	0	9	9
87	R:R:D69	R:R:N287	8.08	Yes	Yes	2	9	9
88	R:R:A71	R:R:L106	4.73	No	No	0	4	4
89	R:R:L106	R:R:L72	4.15	No	No	0	4	4
90	R:R:L280	R:R:L72	4.15	Yes	No	0	7	4
91	R:R:M77	R:R:S73	6.13	Yes	Yes	3	5	7
92	R:R:M77	R:R:T76	3.01	Yes	No	0	5	6
93	R:R:L280	R:R:T76	5.9	Yes	No	0	7	6
94	R:R:K79	R:R:S88	3.06	No	No	0	6	1
95	R:R:I91	R:R:K79	4.36	Yes	No	0	9	6
96	R:R:I80	R:R:S176	7.74	No	No	0	6	6
97	R:R:L81	R:R:W85	3.42	No	Yes	3	8	5
98	R:R:F84	R:R:L83	4.87	Yes	No	0	4	6
99	R:R:F86	R:R:W85	11.02	No	Yes	0	5	5
100	R:R:C96	R:R:I91	3.27	No	Yes	1	9	9
101	R:R:C178	R:R:I91	3.27	No	Yes	1	9	9
102	R:R:F93	R:R:L97	10.96	No	No	0	3	4
103	R:R:F167	R:R:F93	5.36	Yes	No	1	7	3
104	R:R:E94	R:R:T98	4.23	No	No	0	1	4
105	R:R:C178	R:R:C96	7.28	No	No	1	9	9
106	R:R:Q99	R:R:Y177	3.38	No	Yes	0	9	5
107	R:R:C178	R:R:Q99	6.1	No	No	0	9	9
108	R:R:I162	R:R:M100	5.83	No	No	1	4	4
109	R:R:H180	R:R:M100	5.25	Yes	No	1	6	4
110	R:R:M100	R:R:V183	4.56	No	No	0	4	6
111	R:R:F101	R:R:F102	3.22	Yes	No	0	5	4
112	R:R:A105	R:R:F101	5.55	No	Yes	0	2	5
113	R:R:F101	R:R:F156	6.43	Yes	No	0	5	3
114	R:R:F101	R:R:P159	8.67	Yes	No	0	5	4
115	R:R:I103	R:R:V179	3.07	No	Yes	0	4	8
116	R:R:H104	R:R:L158	5.14	Yes	Yes	1	4	4
117	R:R:H104	R:R:V179	5.54	Yes	Yes	1	4	8
118	R:R:H104	R:R:Q181	7.42	Yes	Yes	1	4	4
119	R:R:S107	R:R:Y279	8.9	No	No	0	4	7
120	R:R:A108	R:R:F155	4.16	No	Yes	0	4	5
121	R:R:I109	R:R:V148	3.07	No	No	0	5	5
122	R:R:E110	R:R:F250	8.16	Yes	Yes	0	8	6
123	R:R:E110	R:R:N287	3.94	Yes	Yes	2	8	9
124	R:R:M206	R:R:S111	4.6	Yes	No	1	3	5
125	R:R:D209	R:R:S111	7.36	Yes	No	1	7	5
126	R:R:S111	R:R:Y251	7.63	No	Yes	1	5	6
127	R:R:A147	R:R:T112	3.36	No	No	0	6	3
128	R:R:R150	R:R:T112	5.17	No	No	0	3	3
129	R:R:A147	R:R:I113	3.25	No	No	0	6	6
130	R:R:L114	R:R:Y291	3.52	No	Yes	0	9	9
131	R:R:D209	R:R:L115	9.5	Yes	No	0	7	7
132	R:R:A118	R:R:I213	4.87	No	No	0	8	8
133	R:R:A118	R:R:S216	3.42	No	No	0	8	9
134	R:R:F119	R:R:V123	7.87	No	No	0	6	7
135	R:R:F119	R:R:L135	3.65	No	Yes	0	6	9
136	R:R:D120	R:R:H131	6.3	No	No	6	9	9
137	R:R:D120	R:R:L135	6.79	No	Yes	6	9	9
138	R:R:R121	R:R:Y217	12.35	Yes	No	2	9	9
139	R:R:I220	R:R:R121	5.01	Yes	Yes	0	9	9
140	R:R:H243	R:R:R121	3.39	Yes	Yes	2	9	9
141	R:R:C126	R:R:Y122	6.72	No	Yes	0	8	7
142	R:R:H127	R:R:Y122	11.98	No	Yes	0	4	7
143	R:R:S216	R:R:Y122	3.82	No	Yes	0	9	7
144	R:R:L219	R:R:Y122	8.21	No	Yes	0	2	7
145	R:R:A124	R:R:H131	8.78	No	No	0	9	9
146	R:R:I125	R:R:I220	7.36	No	Yes	0	9	9
147	R:R:I125	R:R:T223	3.04	No	No	0	9	6
148	R:R:C126	R:R:T223	6.76	No	No	0	8	6
149	R:R:H131	R:R:L135	5.14	No	Yes	6	9	9
150	R:R:N136	R:R:V139	4.43	No	No	0	7	4
151	R:R:I143	R:R:V139	3.07	No	No	0	6	4
152	R:R:R150	R:R:V205	9.15	No	Yes	0	3	4
153	R:R:D209	R:R:R150	9.53	Yes	No	0	7	3
154	R:R:F154	R:R:F155	3.22	No	Yes	1	4	5
155	R:R:F154	R:R:V205	9.18	No	Yes	1	4	4
156	R:R:F155	R:R:L158	8.53	Yes	Yes	1	5	4
157	R:R:F155	R:R:V205	3.93	Yes	Yes	1	5	4
158	R:R:F155	R:R:M206	3.73	Yes	Yes	1	5	3
159	R:R:F156	R:R:L160	6.09	No	No	0	3	2
160	R:R:P157	R:R:Y197	12.52	No	No	0	3	4
161	R:R:H180	R:R:L158	16.71	Yes	Yes	1	6	4
162	R:R:L158	R:R:Y197	3.52	Yes	No	0	4	4
163	R:R:L161	R:R:R164	4.86	No	No	0	4	5
164	R:R:L161	R:R:N194	4.12	No	Yes	0	4	6
165	R:R:L161	R:R:Y197	3.52	No	No	0	4	4
166	R:R:H180	R:R:I162	7.95	Yes	No	1	6	4
167	R:R:I162	R:R:N194	4.25	No	Yes	1	4	6
168	R:R:D190	R:R:R164	13.1	No	No	0	7	5
169	R:R:F167	R:R:L165	6.09	Yes	Yes	1	7	7
170	R:R:A187	R:R:L165	4.73	No	Yes	1	8	7
171	R:R:L165	R:R:N194	4.12	Yes	Yes	1	7	6
172	R:R:A187	R:R:F167	4.16	No	Yes	1	8	7
173	R:R:H169	R:R:Y188	8.71	No	No	0	4	9
174	R:R:L186	R:R:S170	4.5	No	No	0	7	6
175	R:R:D182	R:R:L173	9.5	Yes	No	0	6	8
176	R:R:L173	R:R:V183	5.96	No	No	0	8	6
177	R:R:L173	R:R:L186	4.15	No	No	0	8	7
178	R:R:R272	R:R:S174	9.22	Yes	No	0	6	5
179	R:R:H175	R:R:Y177	17.42	Yes	Yes	0	8	5
180	R:R:D182	R:R:H175	6.3	Yes	Yes	1	6	8
181	R:R:H175	R:R:L257	7.71	Yes	Yes	1	8	5
182	R:R:H175	R:R:H261	7.17	Yes	Yes	1	8	7
183	R:R:H175	R:R:R272	3.39	Yes	Yes	1	8	6
184	R:R:V179	R:R:Y177	3.79	Yes	Yes	0	8	5
185	R:R:L280	R:R:Y177	10.55	Yes	Yes	0	7	5
186	R:R:Q181	R:R:V179	10.03	Yes	Yes	1	4	8
187	R:R:D182	R:R:V179	5.84	Yes	Yes	1	6	8
188	R:R:H180	R:R:N194	8.93	Yes	Yes	1	6	6
189	R:R:H180	R:R:R262	3.39	Yes	Yes	1	6	4
190	R:R:L257	R:R:Q181	3.99	Yes	Yes	1	5	4
191	R:R:Q181	R:R:S258	4.33	Yes	No	0	4	7
192	R:R:H261	R:R:Q181	12.36	Yes	Yes	1	7	4
193	R:R:D182	R:R:H261	5.04	Yes	Yes	1	6	7
194	R:R:M184	R:R:V195	3.04	No	No	1	4	5
195	R:R:M184	R:R:R262	7.44	No	Yes	1	4	4
196	R:R:H261	R:R:K185	7.86	Yes	No	1	7	5
197	R:R:K185	R:R:N265	12.59	No	No	0	5	3
198	R:R:K185	R:R:R272	3.71	No	Yes	1	5	6
199	R:R:D190	R:R:P193	3.22	No	No	0	7	3
200	R:R:L192	R:R:P193	3.28	No	No	0	2	3
201	R:R:R262	R:R:V195	6.54	Yes	No	1	4	5
202	R:R:L199	R:R:L203	5.54	No	No	0	4	4
203	R:R:L199	R:R:R262	6.07	No	Yes	0	4	4
204	R:R:I202	R:R:M206	4.37	No	Yes	0	4	3
205	R:R:I202	R:R:S258	9.29	No	No	0	4	7
206	R:R:M206	R:R:V205	3.04	Yes	Yes	1	3	4
207	R:R:L254	R:R:M206	9.9	Yes	Yes	0	3	3
208	R:R:D209	R:R:Y251	5.75	Yes	Yes	1	7	6
209	R:R:V210	R:R:Y251	16.4	Yes	Yes	0	4	6
210	R:R:I213	R:R:V247	4.61	No	No	0	8	8
211	R:R:I213	R:R:Y251	3.63	No	Yes	0	8	6
212	R:R:L215	R:R:L219	4.15	No	No	0	3	2
213	R:R:H243	R:R:Y217	11.98	Yes	No	2	9	9
214	R:R:I244	R:R:Y217	7.25	No	No	0	7	9
215	R:R:F218	R:R:R222	7.48	No	No	0	2	3
216	R:R:L219	R:R:R222	4.86	No	No	0	2	3
217	R:R:F237	R:R:I221	7.54	No	No	0	7	5
218	R:R:C240	R:R:I221	4.91	No	No	0	9	5
219	R:R:A236	R:R:V224	5.09	No	No	0	9	8
220	R:R:F237	R:R:L225	3.65	No	No	0	7	7
221	R:R:L227	R:R:P228	3.28	No	No	0	7	4
222	R:R:E232	R:R:S229	8.62	No	No	0	7	9
223	R:R:K230	R:R:R233	4.95	No	No	0	4	7
224	R:R:F237	R:R:V241	3.93	No	No	0	7	5
225	R:R:H243	R:R:S242	4.18	Yes	No	2	9	9
226	R:R:K294	R:R:S242	3.06	Yes	No	2	9	9
227	R:R:H243	R:R:I290	6.63	Yes	Yes	2	9	9
228	R:R:H243	R:R:Y291	6.53	Yes	Yes	2	9	9
229	R:R:H243	R:R:K294	3.93	Yes	Yes	2	9	9
230	R:R:I286	R:R:V246	7.68	No	No	0	7	8
231	R:R:I290	R:R:V246	9.22	Yes	No	0	9	8
232	R:R:L248	R:R:V252	4.47	No	No	0	4	6
233	R:R:F250	R:R:Y251	13.41	Yes	Yes	0	6	6
234	R:R:F250	R:R:L254	3.65	Yes	Yes	0	6	3
235	R:R:F250	R:R:P283	5.78	Yes	No	0	6	8
236	R:R:P253	R:R:V252	3.53	No	No	0	6	6
237	R:R:I278	R:R:P253	6.77	No	No	0	5	6
238	R:R:L254	R:R:Y279	11.72	Yes	No	0	3	7
239	R:R:G256	R:R:M275	3.49	No	No	0	4	5
240	R:R:H261	R:R:L257	5.14	Yes	Yes	1	7	5
241	R:R:G276	R:R:L257	3.42	No	Yes	0	7	5
242	R:R:F263	R:R:V259	5.24	No	No	0	5	4
243	R:R:M275	R:R:V260	3.04	No	No	0	5	4
244	R:R:H261	R:R:R272	13.54	Yes	Yes	1	7	6
245	R:R:F263	R:R:R262	7.48	No	Yes	0	5	4
246	R:R:H268	R:R:P269	9.15	No	No	0	5	3
247	R:R:H268	R:R:I270	7.95	No	No	0	5	3
248	R:R:I270	R:R:V274	3.07	No	No	0	3	4
249	R:R:D277	R:R:L281	9.5	No	No	0	6	6
250	R:R:L280	R:R:Y279	14.07	Yes	No	0	7	7
251	R:R:I286	R:R:L282	7.14	No	No	0	7	5
252	R:R:P283	R:R:P284	5.84	No	No	0	8	9
253	R:R:N287	R:R:Y291	6.98	Yes	Yes	2	9	9
254	R:R:I290	R:R:Y291	15.71	Yes	Yes	2	9	9
255	R:R:I290	R:R:K294	4.36	Yes	Yes	2	9	9
256	R:R:G292	R:R:I298	3.53	No	Yes	0	8	7
257	R:R:I298	R:R:T295	6.08	Yes	No	0	7	9
258	R:R:K296	R:R:R299	3.71	No	No	0	6	7
259	R:R:Q297	R:R:R301	7.01	No	Yes	4	6	7
260	R:R:K294	R:R:T239	3	Yes	No	0	9	9
261	R:R:L135	R:R:V134	2.98	Yes	No	0	9	6
262	R:R:L267	R:R:V271	2.98	No	No	0	4	3
263	R:R:N171	R:R:V12	2.96	No	No	0	6	7
264	R:R:L60	R:R:T140	2.95	No	No	0	7	7
265	R:R:I43	R:R:I47	2.94	No	Yes	4	4	5
266	R:R:D277	R:R:V273	2.92	No	No	0	6	6
267	R:R:I244	R:R:L248	2.85	No	No	0	7	4
268	R:R:I255	R:R:L254	2.85	No	Yes	0	3	3
269	R:R:L30	R:R:M77	2.83	No	Yes	0	5	5
270	R:R:L62	R:R:M117	2.83	No	No	0	8	9
271	R:R:Q142	R:R:T138	2.83	No	No	0	2	4
272	R:R:E90	R:R:T10	2.82	No	No	0	4	5
273	R:R:E51	R:R:T50	2.82	No	No	0	7	4
274	R:R:K163	R:R:L97	2.82	No	No	0	3	4
275	R:R:G27	R:R:W85	2.81	No	Yes	0	8	5
276	R:R:A201	R:R:F155	2.77	No	Yes	0	3	5
277	R:R:A56	R:R:Y59	2.67	No	Yes	0	7	9
278	R:R:F101	R:R:S152	2.64	Yes	No	0	5	3
279	R:R:F212	R:R:V208	2.62	No	No	0	4	1
280	R:R:F102	R:R:T98	2.59	No	No	0	4	4
281	R:R:R301	R:R:T300	2.59	Yes	No	0	7	1
282	R:R:V48	R:R:Y59	2.52	No	Yes	0	8	9
283	R:R:M117	R:R:R121	2.48	No	Yes	0	9	9
284	R:R:F212	R:R:L215	2.44	No	No	0	4	3
285	R:R:L83	R:R:R89	2.43	No	No	0	6	5
286	R:R:L225	R:R:R233	2.43	No	No	0	7	7
287	R:R:L62	R:R:Y59	2.34	No	Yes	0	8	9
288	R:R:H127	R:R:R130	2.26	No	No	0	4	6
289	R:R:G18	R:R:P17	2.03	No	Yes	0	4	7
290	R:R:A108	R:R:G151	1.95	No	No	0	4	6
291	R:R:A147	R:R:G144	1.95	No	No	0	6	5
292	R:R:G207	R:R:V210	1.84	No	Yes	0	2	4
293	R:R:G256	R:R:V259	1.84	No	No	0	4	4
294	R:R:G264	R:R:V260	1.84	No	No	0	4	4
295	R:R:A166	R:R:C4	1.81	No	No	0	5	4
296	R:R:A82	R:R:S88	1.71	No	No	0	3	1
297	R:R:A95	R:R:S92	1.71	No	No	0	5	8
298	R:R:A37	R:R:V285	1.7	No	No	0	7	5
299	R:R:A166	R:R:T7	1.68	No	No	0	5	4
300	R:R:L158	R:R:P159	1.64	Yes	No	0	4	4
301	R:R:C240	R:R:I220	1.64	No	Yes	0	9	9
302	R:R:A95	R:R:I91	1.62	No	Yes	0	5	9
303	R:R:S214	R:R:V210	1.62	No	Yes	0	3	4
304	R:R:A249	R:R:I286	1.62	No	No	0	5	7
305	R:R:V285	R:R:V36	1.6	No	No	0	5	3
306	R:R:I103	R:R:S75	1.55	No	No	0	4	5
307	R:R:I43	R:R:V302	1.54	No	No	4	4	6
308	R:R:I47	R:R:V302	1.54	Yes	No	4	5	6
309	R:R:I145	R:R:V149	1.54	No	No	0	3	2
310	R:R:I220	R:R:V224	1.54	Yes	No	0	9	8
311	R:R:H127	R:R:P128	1.53	No	No	0	4	9
312	R:R:M211	R:R:V210	1.52	No	Yes	0	3	4
313	R:R:M275	R:R:V271	1.52	No	No	0	5	3
314	R:R:K235	R:R:T239	1.5	No	No	0	9	9
315	R:R:L192	R:R:V196	1.49	No	No	0	2	2
316	R:R:L227	R:R:V224	1.49	No	No	0	7	8
317	R:R:L165	R:R:T191	1.47	Yes	No	0	7	7
318	R:R:C168	R:R:H169	1.47	No	No	0	9	4
319	R:R:L204	R:R:T200	1.47	No	No	0	3	4
320	R:R:I289	R:R:I290	1.47	No	Yes	0	6	9
321	R:R:N136	R:R:T138	1.46	No	No	0	7	4
322	R:R:F28	R:R:P29	1.44	No	No	0	4	3
323	R:R:E90	R:R:V12	1.43	No	No	0	4	7
324	R:R:C63	R:R:R49	1.39	No	No	0	5	1
325	R:R:E232	R:R:L227	1.33	No	No	0	7	7
326	R:R:H55	R:R:L60	1.29	No	No	0	8	7
327	R:R:F46	R:R:M305	1.24	No	No	0	3	4
328	R:R:L129	R:R:R130	1.21	No	No	0	9	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.3314	7	1	0
2	R:R:F11	5.4425	4	1	9
3	R:R:I16	4.18	4	5	6
4	R:R:P17	4.0975	4	0	7
5	R:R:Y34	7.632	5	3	9
6	R:R:N41	5.795	4	0	9
7	R:R:I47	3.845	4	4	5
8	R:R:Y59	5.545	6	4	9
9	R:R:F61	5.6	5	0	8
10	R:R:I68	4.305	4	0	5
11	R:R:D69	6.78	4	2	9
12	R:R:S73	4.745	4	3	7
13	R:R:M77	6.585	4	3	5
14	R:R:F84	7.31	5	5	4
15	R:R:W85	6.876	5	3	5
16	R:R:I91	3.36	5	1	9
17	R:R:F101	5.302	5	0	5
18	R:R:H104	8.75	4	1	4
19	R:R:E110	6.3225	4	2	8
20	R:R:R121	5.8075	4	2	9
21	R:R:Y122	7.6825	4	0	7
22	R:R:L135	4.64	4	6	9
23	R:R:F155	4.39	6	1	5
24	R:R:L158	7.02667	6	1	4
25	R:R:L165	4.1025	4	1	7
26	R:R:F167	6.045	4	1	7
27	R:R:H175	8.398	5	1	8
28	R:R:Y177	8.785	4	0	5
29	R:R:V179	5.654	5	1	8
30	R:R:H180	10.1117	6	1	6
31	R:R:Q181	8.74167	6	1	4
32	R:R:D182	6.67	4	1	6
33	R:R:N194	5.355	4	1	6
34	R:R:V205	6.325	4	1	4
35	R:R:M206	5.128	5	1	3
36	R:R:D209	8.035	4	1	7
37	R:R:V210	5.345	4	0	4
38	R:R:I220	3.8875	4	0	9
39	R:R:H243	6.10667	6	2	9
40	R:R:F250	7.75	4	0	6
41	R:R:Y251	9.364	5	1	6
42	R:R:L254	7.03	4	0	3
43	R:R:L257	5.065	4	1	5
44	R:R:H261	8.51833	6	1	7
45	R:R:R262	7.09	6	1	4
46	R:R:R272	7.465	4	1	6
47	R:R:L280	8.6675	4	0	7
48	R:R:N287	6.4675	4	2	9
49	R:R:I290	7.478	5	2	9
50	R:R:Y291	8.185	4	2	9
51	R:R:K294	3.5875	4	2	9
52	R:R:I298	5.0275	4	0	7
53	R:R:R301	5.86833	6	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H104	R:R:V179	12.4502	5.54	Yes	Yes	1	4	8
2	R:R:V179	R:R:Y177	22.1217	3.79	Yes	Yes	0	8	5
3	R:R:Q99	R:R:Y177	58.412	3.38	No	Yes	0	9	5
4	R:R:C178	R:R:Q99	57.5041	6.1	No	No	0	9	9
5	R:R:C178	R:R:I91	51.6227	3.27	No	Yes	1	9	9
6	R:R:I91	R:R:L13	50.0665	4.28	Yes	No	0	9	8
7	R:R:L13	R:R:L83	48.8636	4.15	No	No	0	8	6
8	R:R:L83	R:R:R89	26.3009	2.43	No	No	0	6	5
9	R:R:R89	R:R:V12	22.3033	5.23	No	No	0	5	7
10	R:R:N171	R:R:V12	18.2473	2.96	No	No	0	6	7
11	R:R:H8	R:R:N171	16.8823	12.75	No	No	0	3	6
12	R:R:F6	R:R:H8	15.5108	6.79	No	No	0	3	3
13	L:L:?1	R:R:Q181	10.6864	14.32	Yes	Yes	1	0	4
14	R:R:H180	R:R:N194	12.5604	8.93	Yes	Yes	1	6	6
15	R:R:L165	R:R:N194	12.2718	4.12	Yes	Yes	1	7	6
16	R:R:F84	R:R:L83	23.4445	4.87	Yes	No	0	4	6
17	R:R:F84	R:R:I16	13.8346	6.28	Yes	Yes	5	4	6
18	R:R:I16	R:R:P17	12.6836	3.39	Yes	Yes	0	6	7
19	R:R:L280	R:R:Y177	72.9858	10.55	Yes	Yes	0	7	5
20	R:R:L280	R:R:T76	34.1212	5.9	Yes	No	0	7	6
21	R:R:M77	R:R:T76	32.834	3.01	Yes	No	0	5	6
22	R:R:M77	R:R:Y34	20.6173	14.37	Yes	Yes	3	5	9
23	R:R:L81	R:R:Y34	15.4362	4.69	No	Yes	3	8	9
24	R:R:L81	R:R:W85	12.6609	3.42	No	Yes	3	8	5
25	L:L:?1	R:R:I202	18.7628	10.24	Yes	No	0	0	4
26	R:R:I202	R:R:M206	23.0555	4.37	No	Yes	0	4	3
27	R:R:L254	R:R:M206	32.74	9.9	Yes	Yes	0	3	3
28	R:R:F250	R:R:L254	72.4638	3.65	Yes	Yes	0	6	3
29	R:R:E110	R:R:F250	69.04	8.16	Yes	Yes	0	8	6
30	R:R:E110	R:R:N287	96.4044	3.94	Yes	Yes	2	8	9
31	R:R:N287	R:R:Y291	100	6.98	Yes	Yes	2	9	9
32	R:R:H243	R:R:Y291	92.0565	6.53	Yes	Yes	2	9	9
33	R:R:H243	R:R:R121	83.75	3.39	Yes	Yes	2	9	9
34	R:R:M117	R:R:R121	73.2224	2.48	No	Yes	0	9	9
35	R:R:L62	R:R:M117	50.9743	2.83	No	No	0	8	9
36	R:R:L62	R:R:Y59	49.9789	2.34	No	Yes	0	8	9
37	R:R:L54	R:R:Y59	20.8345	11.72	No	Yes	4	9	9
38	R:R:L54	R:R:R301	19.5636	4.86	No	Yes	4	9	7
39	R:R:I47	R:R:R301	21.2398	5.01	Yes	Yes	4	5	7
40	R:R:Q297	R:R:Y59	20.8281	5.64	No	Yes	4	6	9
41	R:R:Q297	R:R:R301	19.7354	7.01	No	Yes	4	6	7
42	R:R:I298	R:R:I47	10.6702	5.89	Yes	Yes	0	7	5
43	R:R:E51	R:R:R301	10.6572	10.47	No	Yes	0	7	7
44	R:R:F61	R:R:M117	26.5214	3.73	Yes	No	0	8	9
45	R:R:F155	R:R:L158	20.3968	8.53	Yes	Yes	1	5	4
46	R:R:E110	R:R:I68	37.0781	4.1	Yes	Yes	0	8	5
47	R:R:L280	R:R:L72	38.6603	4.15	Yes	No	0	7	4
48	R:R:L106	R:R:L72	38.4269	4.15	No	No	0	4	4
49	R:R:L254	R:R:Y279	45.6603	11.72	Yes	No	0	3	7
50	R:R:M206	R:R:S111	11.3932	4.6	Yes	No	1	3	5
51	R:R:I213	R:R:Y251	14.8332	3.63	No	Yes	0	8	6
52	R:R:A118	R:R:I213	12.8522	4.87	No	No	0	8	8
53	R:R:A118	R:R:S216	12.2524	3.42	No	No	0	8	9
54	R:R:I220	R:R:R121	23.2824	5.01	Yes	Yes	0	9	9
55	R:R:S216	R:R:Y122	11.7271	3.82	No	Yes	0	9	7
56	L:L:?1	R:R:R262	14.791	11.62	Yes	Yes	1	0	4
57	R:R:F263	R:R:R262	11.6947	7.48	No	Yes	0	5	4
58	R:R:F263	R:R:V259	10.2552	5.24	No	No	0	5	4
59	R:R:F155	R:R:M206	18.1467	3.73	Yes	Yes	1	5	3
60	R:R:I68	R:R:L106	38.2194	4.28	Yes	No	0	5	4
61	R:R:L280	R:R:Y279	45.0443	14.07	Yes	No	0	7	7
62	R:R:H175	R:R:Y177	13.6627	17.42	Yes	Yes	0	8	5
63	R:R:F250	R:R:Y251	12.1875	13.41	Yes	Yes	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H104	16.9	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L158	6.62	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:H180	18.44	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q181	14.32	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:G198	8.18	1	Yes	No	0	4	0	1
L:L:?1	R:R:I202	10.24	1	Yes	No	0	4	0	1
L:L:?1	R:R:R262	11.62	1	Yes	Yes	0	4	0	1
R:R:I162	R:R:M100	5.83	1	No	No	4	4	2	2
R:R:H180	R:R:M100	5.25	1	Yes	No	6	4	1	2
R:R:H104	R:R:L158	5.14	1	Yes	Yes	4	4	1	1
R:R:H104	R:R:V179	5.54	1	Yes	Yes	4	8	1	2
R:R:H104	R:R:Q181	7.42	1	Yes	Yes	4	4	1	1
R:R:F155	R:R:L158	8.53	1	Yes	Yes	5	4	2	1
R:R:F155	R:R:M206	3.73	1	Yes	Yes	5	3	2	2
R:R:H180	R:R:L158	16.71	1	Yes	Yes	6	4	1	1
R:R:L158	R:R:Y197	3.52	1	Yes	No	4	4	1	2
R:R:H180	R:R:I162	7.95	1	Yes	No	6	4	1	2
R:R:I162	R:R:N194	4.25	1	No	Yes	4	6	2	2
R:R:Q181	R:R:V179	10.03	1	Yes	Yes	4	8	1	2
R:R:H180	R:R:N194	8.93	1	Yes	Yes	6	6	1	2
R:R:H180	R:R:R262	3.39	1	Yes	Yes	6	4	1	1
R:R:L257	R:R:Q181	3.99	1	Yes	Yes	5	4	2	1
R:R:Q181	R:R:S258	4.33	1	Yes	No	4	7	1	2
R:R:H261	R:R:Q181	12.36	1	Yes	Yes	7	4	2	1
R:R:M184	R:R:V195	3.04	1	No	No	4	5	2	2
R:R:M184	R:R:R262	7.44	1	No	Yes	4	4	2	1
R:R:R262	R:R:V195	6.54	1	Yes	No	4	5	1	2
R:R:L199	R:R:R262	6.07	0	No	Yes	4	4	2	1
R:R:I202	R:R:M206	4.37	0	No	Yes	4	3	1	2
R:R:I202	R:R:S258	9.29	0	No	No	4	7	1	2
R:R:H261	R:R:L257	5.14	1	Yes	Yes	7	5	2	2
R:R:F263	R:R:R262	7.48	0	No	Yes	5	4	2	1
R:R:L158	R:R:P159	1.64	1	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F76_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	281
Number of Links	328
Number of Hubs	53
Number of Links mediated by Hubs	186
Number of Communities	6
Number of Nodes involved in Communities	64
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	64658
Length Of Smallest Path	3
Average Path Length	14.646
Length of Longest Path	33
Minimum Path Strength	1.41
Average Path Strength	5.95317
Maximum Path Strength	17.67
Minimum Path Correlation	0.7
Average Path Correlation	0.914039
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	41.7618
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.7932
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PPI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PPI
Name	Propanoic acid
Synonyms	Propionic acid Sodium propionate Propanoic acid
Identifier
Formula	C3 H6 O2
Molecular Weight	74.079
SMILES
PubChem	1032
Formal Charge	0
Total Atoms	11
Total Chiral Atoms	0
Total Bonds	10
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H255
Sequence	>8F76_nogp_Chain_R C N F T H A T F V L I G I P G L E K A H F W V G F P L L S M Y V V A M F G N C I V V F I V R T E R S L H A P M Y L F L C M L A A I D L A L S T S T M P K I L A L F W F D S R E I S F E A C L T Q M F F I H A L S A I E S T I L L A M A F D R Y V A I C H P L R H A A V L N N T V T A Q I G I V A V V R G S L F F F P L P L L I K R L A F C H S N V L S H S Y C V H Q D V M K L A Y A D T L P N V V Y G L T A I L L V M G V D V M F I S L S Y F L I I R T V L Q L P S K S E R A K A F G T C V S H I G V V L A F Y V P L I G L S V V H R F G N S L H P I V R V V M G D I Y L L L P P V I N P I I Y G A K T K Q I R T R V L A M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8F76	O1	Odorant receptors	Odorant family 51	OR51E2	Homo sapiens	Propanoic acid	-	Gs/β1/γ2	3.1	2023-03-22	doi.org/10.1038/s41586-023-05798-y
	8F76 (No Gprot)	O1	Odorant receptors	Odorant family 51	OR51E2	Homo sapiens	Propanoic acid	-		3.1	2023-03-22	doi.org/10.1038/s41586-023-05798-y

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