psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H104	16.9	Yes	Yes	1	0	4
2	L:L:?1	R:R:L158	6.62	Yes	Yes	1	0	4
3	L:L:?1	R:R:H180	18.44	Yes	Yes	1	0	6
4	L:L:?1	R:R:Q181	14.32	Yes	Yes	1	0	4
5	L:L:?1	R:R:G198	8.18	Yes	No	0	0	4
6	L:L:?1	R:R:I202	10.24	Yes	No	0	0	4
7	L:L:?1	R:R:R262	11.62	Yes	Yes	1	0	4
8	R:R:C4	R:R:N5	3.15	No	No	0	4	8
9	R:R:C168	R:R:C4	7.28	No	No	0	9	4
10	R:R:F6	R:R:N5	10.87	No	No	0	3	8
11	R:R:F6	R:R:H8	6.79	No	No	0	3	3
12	R:R:C168	R:R:F6	4.19	No	No	0	9	3
13	R:R:H8	R:R:N171	12.75	No	No	0	3	6
14	R:R:F11	R:R:F93	5.36	Yes	No	1	9	3
15	R:R:C96	R:R:F11	4.19	No	Yes	1	9	9
16	R:R:F11	R:R:F167	8.57	Yes	Yes	1	9	7
17	R:R:F11	R:R:L186	3.65	Yes	No	0	9	7
18	R:R:R89	R:R:V12	5.23	No	No	0	5	7
19	R:R:L13	R:R:L83	4.15	No	No	0	8	6
20	R:R:I91	R:R:L13	4.28	Yes	No	0	9	8
21	R:R:I14	R:R:R89	3.76	No	No	0	5	5
22	R:R:I14	R:R:V172	3.07	No	No	0	5	3
23	R:R:F84	R:R:G15	3.01	Yes	No	0	4	9
24	R:R:G15	R:R:S176	3.71	No	No	0	9	6
25	R:R:I16	R:R:P17	3.39	Yes	Yes	0	6	7
26	R:R:H23	R:R:I16	3.98	No	Yes	5	6	6
27	R:R:I16	R:R:V26	3.07	Yes	No	5	6	6
28	R:R:F84	R:R:I16	6.28	Yes	Yes	5	4	6
29	R:R:P17	R:R:P269	3.9	Yes	No	0	7	3
30	R:R:P17	R:R:V273	7.07	Yes	No	0	7	6
31	R:R:A22	R:R:L19	3.15	No	No	0	4	3
32	R:R:E20	R:R:H23	11.08	No	No	0	5	6
33	R:R:A22	R:R:W25	5.19	No	No	0	4	3
34	R:R:F84	R:R:H23	15.84	Yes	No	5	4	6
35	R:R:F24	R:R:F28	7.5	No	No	0	2	4
36	R:R:F24	R:R:W85	8.02	No	Yes	0	2	5
37	R:R:F28	R:R:W25	4.01	No	No	0	4	3
38	R:R:F84	R:R:V26	6.55	Yes	No	5	4	6
39	R:R:L31	R:R:L81	4.15	No	No	3	5	8
40	R:R:L31	R:R:W85	9.11	No	Yes	3	5	5
41	R:R:M33	R:R:V285	3.04	No	No	0	5	5
42	R:R:M38	R:R:Y34	7.18	No	Yes	3	5	9
43	R:R:S73	R:R:Y34	6.36	Yes	Yes	3	7	9
44	R:R:M77	R:R:Y34	14.37	Yes	Yes	3	5	9
45	R:R:P78	R:R:Y34	5.56	No	Yes	0	9	9
46	R:R:L81	R:R:Y34	4.69	No	Yes	3	8	9
47	R:R:A37	R:R:S73	3.42	No	Yes	0	7	7
48	R:R:M38	R:R:S73	3.07	No	Yes	3	5	7
49	R:R:M38	R:R:T74	3.01	No	No	0	5	7
50	R:R:F39	R:R:I43	3.77	No	No	0	1	4
51	R:R:G40	R:R:P288	4.06	No	No	0	7	9
52	R:R:A66	R:R:N41	4.69	No	Yes	0	9	9
53	R:R:D69	R:R:N41	6.73	Yes	Yes	0	9	9
54	R:R:L70	R:R:N41	6.87	No	Yes	0	5	9
55	R:R:N41	R:R:P288	4.89	Yes	No	0	9	9
56	R:R:I298	R:R:V44	4.61	Yes	No	0	7	7
57	R:R:C63	R:R:V45	5.12	No	No	0	5	6
58	R:R:F46	R:R:T50	11.67	No	No	0	3	4
59	R:R:I298	R:R:I47	5.89	Yes	Yes	0	7	5
60	R:R:I47	R:R:R301	5.01	Yes	Yes	4	5	7
61	R:R:C63	R:R:V48	8.54	No	No	0	5	8
62	R:R:E51	R:R:R301	10.47	No	Yes	0	7	7
63	R:R:H55	R:R:R52	5.64	No	No	0	8	4
64	R:R:R301	R:R:S53	5.27	Yes	No	0	7	6
65	R:R:L54	R:R:Y59	11.72	No	Yes	4	9	9
66	R:R:L54	R:R:Q297	7.99	No	No	4	9	6
67	R:R:L54	R:R:R301	4.86	No	Yes	4	9	7
68	R:R:P57	R:R:T140	3.5	No	No	0	9	7
69	R:R:M58	R:R:Y59	8.38	No	Yes	0	9	9
70	R:R:Q297	R:R:Y59	5.64	No	Yes	4	6	9
71	R:R:L60	R:R:N137	5.49	No	No	0	7	2
72	R:R:A116	R:R:F61	5.55	No	Yes	0	5	8
73	R:R:F61	R:R:M117	3.73	Yes	No	0	8	9
74	R:R:D120	R:R:F61	7.17	No	Yes	0	9	8
75	R:R:F61	R:R:T140	7.78	Yes	No	0	8	7
76	R:R:F61	R:R:I143	3.77	Yes	No	0	8	6
77	R:R:G144	R:R:M64	3.49	No	No	0	5	7
78	R:R:I113	R:R:L65	4.28	No	No	0	6	9
79	R:R:L114	R:R:L65	4.15	No	No	0	9	9
80	R:R:L65	R:R:N287	6.87	No	Yes	0	9	9
81	R:R:I68	R:R:L106	4.28	Yes	No	0	5	4
82	R:R:I109	R:R:I68	4.42	No	Yes	0	5	5
83	R:R:E110	R:R:I68	4.1	Yes	Yes	0	8	5
84	R:R:I113	R:R:I68	4.42	No	Yes	0	6	5
85	R:R:D69	R:R:E110	9.09	Yes	Yes	2	9	8
86	R:R:D69	R:R:P284	3.22	Yes	No	0	9	9
87	R:R:D69	R:R:N287	8.08	Yes	Yes	2	9	9
88	R:R:A71	R:R:L106	4.73	No	No	0	4	4
89	R:R:L106	R:R:L72	4.15	No	No	0	4	4
90	R:R:L280	R:R:L72	4.15	Yes	No	0	7	4
91	R:R:M77	R:R:S73	6.13	Yes	Yes	3	5	7
92	R:R:M77	R:R:T76	3.01	Yes	No	0	5	6
93	R:R:L280	R:R:T76	5.9	Yes	No	0	7	6
94	R:R:K79	R:R:S88	3.06	No	No	0	6	1
95	R:R:I91	R:R:K79	4.36	Yes	No	0	9	6
96	R:R:I80	R:R:S176	7.74	No	No	0	6	6
97	R:R:L81	R:R:W85	3.42	No	Yes	3	8	5
98	R:R:F84	R:R:L83	4.87	Yes	No	0	4	6
99	R:R:F86	R:R:W85	11.02	No	Yes	0	5	5
100	R:R:C96	R:R:I91	3.27	No	Yes	1	9	9
101	R:R:C178	R:R:I91	3.27	No	Yes	1	9	9
102	R:R:F93	R:R:L97	10.96	No	No	0	3	4
103	R:R:F167	R:R:F93	5.36	Yes	No	1	7	3
104	R:R:E94	R:R:T98	4.23	No	No	0	1	4
105	R:R:C178	R:R:C96	7.28	No	No	1	9	9
106	R:R:Q99	R:R:Y177	3.38	No	Yes	0	9	5
107	R:R:C178	R:R:Q99	6.1	No	No	0	9	9
108	R:R:I162	R:R:M100	5.83	No	No	1	4	4
109	R:R:H180	R:R:M100	5.25	Yes	No	1	6	4
110	R:R:M100	R:R:V183	4.56	No	No	0	4	6
111	R:R:F101	R:R:F102	3.22	Yes	No	0	5	4
112	R:R:A105	R:R:F101	5.55	No	Yes	0	2	5
113	R:R:F101	R:R:F156	6.43	Yes	No	0	5	3
114	R:R:F101	R:R:P159	8.67	Yes	No	0	5	4
115	R:R:I103	R:R:V179	3.07	No	Yes	0	4	8
116	R:R:H104	R:R:L158	5.14	Yes	Yes	1	4	4
117	R:R:H104	R:R:V179	5.54	Yes	Yes	1	4	8
118	R:R:H104	R:R:Q181	7.42	Yes	Yes	1	4	4
119	R:R:S107	R:R:Y279	8.9	No	No	0	4	7
120	R:R:A108	R:R:F155	4.16	No	Yes	0	4	5
121	R:R:I109	R:R:V148	3.07	No	No	0	5	5
122	R:R:E110	R:R:F250	8.16	Yes	Yes	0	8	6
123	R:R:E110	R:R:N287	3.94	Yes	Yes	2	8	9
124	R:R:M206	R:R:S111	4.6	Yes	No	1	3	5
125	R:R:D209	R:R:S111	7.36	Yes	No	1	7	5
126	R:R:S111	R:R:Y251	7.63	No	Yes	1	5	6
127	R:R:A147	R:R:T112	3.36	No	No	0	6	3
128	R:R:R150	R:R:T112	5.17	No	No	0	3	3
129	R:R:A147	R:R:I113	3.25	No	No	0	6	6
130	R:R:L114	R:R:Y291	3.52	No	Yes	0	9	9
131	R:R:D209	R:R:L115	9.5	Yes	No	0	7	7
132	R:R:A118	R:R:I213	4.87	No	No	0	8	8
133	R:R:A118	R:R:S216	3.42	No	No	0	8	9
134	R:R:F119	R:R:V123	7.87	No	No	0	6	7
135	R:R:F119	R:R:L135	3.65	No	Yes	0	6	9
136	R:R:D120	R:R:H131	6.3	No	No	6	9	9
137	R:R:D120	R:R:L135	6.79	No	Yes	6	9	9
138	R:R:R121	R:R:Y217	12.35	Yes	No	2	9	9
139	R:R:I220	R:R:R121	5.01	Yes	Yes	0	9	9
140	R:R:H243	R:R:R121	3.39	Yes	Yes	2	9	9
141	R:R:C126	R:R:Y122	6.72	No	Yes	0	8	7
142	R:R:H127	R:R:Y122	11.98	No	Yes	0	4	7
143	R:R:S216	R:R:Y122	3.82	No	Yes	0	9	7
144	R:R:L219	R:R:Y122	8.21	No	Yes	0	2	7
145	R:R:A124	R:R:H131	8.78	No	No	0	9	9
146	R:R:I125	R:R:I220	7.36	No	Yes	0	9	9
147	R:R:I125	R:R:T223	3.04	No	No	0	9	6
148	R:R:C126	R:R:T223	6.76	No	No	0	8	6
149	R:R:H131	R:R:L135	5.14	No	Yes	6	9	9
150	R:R:N136	R:R:V139	4.43	No	No	0	7	4
151	R:R:I143	R:R:V139	3.07	No	No	0	6	4
152	R:R:R150	R:R:V205	9.15	No	Yes	0	3	4
153	R:R:D209	R:R:R150	9.53	Yes	No	0	7	3
154	R:R:F154	R:R:F155	3.22	No	Yes	1	4	5
155	R:R:F154	R:R:V205	9.18	No	Yes	1	4	4
156	R:R:F155	R:R:L158	8.53	Yes	Yes	1	5	4
157	R:R:F155	R:R:V205	3.93	Yes	Yes	1	5	4
158	R:R:F155	R:R:M206	3.73	Yes	Yes	1	5	3
159	R:R:F156	R:R:L160	6.09	No	No	0	3	2
160	R:R:P157	R:R:Y197	12.52	No	No	0	3	4
161	R:R:H180	R:R:L158	16.71	Yes	Yes	1	6	4
162	R:R:L158	R:R:Y197	3.52	Yes	No	0	4	4
163	R:R:L161	R:R:R164	4.86	No	No	0	4	5
164	R:R:L161	R:R:N194	4.12	No	Yes	0	4	6
165	R:R:L161	R:R:Y197	3.52	No	No	0	4	4
166	R:R:H180	R:R:I162	7.95	Yes	No	1	6	4
167	R:R:I162	R:R:N194	4.25	No	Yes	1	4	6
168	R:R:D190	R:R:R164	13.1	No	No	0	7	5
169	R:R:F167	R:R:L165	6.09	Yes	Yes	1	7	7
170	R:R:A187	R:R:L165	4.73	No	Yes	1	8	7
171	R:R:L165	R:R:N194	4.12	Yes	Yes	1	7	6
172	R:R:A187	R:R:F167	4.16	No	Yes	1	8	7
173	R:R:H169	R:R:Y188	8.71	No	No	0	4	9
174	R:R:L186	R:R:S170	4.5	No	No	0	7	6
175	R:R:D182	R:R:L173	9.5	Yes	No	0	6	8
176	R:R:L173	R:R:V183	5.96	No	No	0	8	6
177	R:R:L173	R:R:L186	4.15	No	No	0	8	7
178	R:R:R272	R:R:S174	9.22	Yes	No	0	6	5
179	R:R:H175	R:R:Y177	17.42	Yes	Yes	0	8	5
180	R:R:D182	R:R:H175	6.3	Yes	Yes	1	6	8
181	R:R:H175	R:R:L257	7.71	Yes	Yes	1	8	5
182	R:R:H175	R:R:H261	7.17	Yes	Yes	1	8	7
183	R:R:H175	R:R:R272	3.39	Yes	Yes	1	8	6
184	R:R:V179	R:R:Y177	3.79	Yes	Yes	0	8	5
185	R:R:L280	R:R:Y177	10.55	Yes	Yes	0	7	5
186	R:R:Q181	R:R:V179	10.03	Yes	Yes	1	4	8
187	R:R:D182	R:R:V179	5.84	Yes	Yes	1	6	8
188	R:R:H180	R:R:N194	8.93	Yes	Yes	1	6	6
189	R:R:H180	R:R:R262	3.39	Yes	Yes	1	6	4
190	R:R:L257	R:R:Q181	3.99	Yes	Yes	1	5	4
191	R:R:Q181	R:R:S258	4.33	Yes	No	0	4	7
192	R:R:H261	R:R:Q181	12.36	Yes	Yes	1	7	4
193	R:R:D182	R:R:H261	5.04	Yes	Yes	1	6	7
194	R:R:M184	R:R:V195	3.04	No	No	1	4	5
195	R:R:M184	R:R:R262	7.44	No	Yes	1	4	4
196	R:R:H261	R:R:K185	7.86	Yes	No	1	7	5
197	R:R:K185	R:R:N265	12.59	No	No	0	5	3
198	R:R:K185	R:R:R272	3.71	No	Yes	1	5	6
199	R:R:D190	R:R:P193	3.22	No	No	0	7	3
200	R:R:L192	R:R:P193	3.28	No	No	0	2	3
201	R:R:R262	R:R:V195	6.54	Yes	No	1	4	5
202	R:R:L199	R:R:L203	5.54	No	No	0	4	4
203	R:R:L199	R:R:R262	6.07	No	Yes	0	4	4
204	R:R:I202	R:R:M206	4.37	No	Yes	0	4	3
205	R:R:I202	R:R:S258	9.29	No	No	0	4	7
206	R:R:M206	R:R:V205	3.04	Yes	Yes	1	3	4
207	R:R:L254	R:R:M206	9.9	Yes	Yes	0	3	3
208	R:R:D209	R:R:Y251	5.75	Yes	Yes	1	7	6
209	R:R:V210	R:R:Y251	16.4	Yes	Yes	0	4	6
210	R:R:I213	R:R:V247	4.61	No	No	0	8	8
211	R:R:I213	R:R:Y251	3.63	No	Yes	0	8	6
212	R:R:L215	R:R:L219	4.15	No	No	0	3	2
213	R:R:H243	R:R:Y217	11.98	Yes	No	2	9	9
214	R:R:I244	R:R:Y217	7.25	No	No	0	7	9
215	R:R:F218	R:R:R222	7.48	No	No	0	2	3
216	R:R:L219	R:R:R222	4.86	No	No	0	2	3
217	R:R:F237	R:R:I221	7.54	No	No	0	7	5
218	R:R:C240	R:R:I221	4.91	No	No	0	9	5
219	R:R:A236	R:R:V224	5.09	No	No	0	9	8
220	R:R:F237	R:R:L225	3.65	No	No	0	7	7
221	R:R:L227	R:R:P228	3.28	No	No	0	7	4
222	R:R:E232	R:R:S229	8.62	No	No	0	7	9
223	R:R:K230	R:R:R233	4.95	No	No	0	4	7
224	R:R:F237	R:R:V241	3.93	No	No	0	7	5
225	R:R:H243	R:R:S242	4.18	Yes	No	2	9	9
226	R:R:K294	R:R:S242	3.06	Yes	No	2	9	9
227	R:R:H243	R:R:I290	6.63	Yes	Yes	2	9	9
228	R:R:H243	R:R:Y291	6.53	Yes	Yes	2	9	9
229	R:R:H243	R:R:K294	3.93	Yes	Yes	2	9	9
230	R:R:I286	R:R:V246	7.68	No	No	0	7	8
231	R:R:I290	R:R:V246	9.22	Yes	No	0	9	8
232	R:R:L248	R:R:V252	4.47	No	No	0	4	6
233	R:R:F250	R:R:Y251	13.41	Yes	Yes	0	6	6
234	R:R:F250	R:R:L254	3.65	Yes	Yes	0	6	3
235	R:R:F250	R:R:P283	5.78	Yes	No	0	6	8
236	R:R:P253	R:R:V252	3.53	No	No	0	6	6
237	R:R:I278	R:R:P253	6.77	No	No	0	5	6
238	R:R:L254	R:R:Y279	11.72	Yes	No	0	3	7
239	R:R:G256	R:R:M275	3.49	No	No	0	4	5
240	R:R:H261	R:R:L257	5.14	Yes	Yes	1	7	5
241	R:R:G276	R:R:L257	3.42	No	Yes	0	7	5
242	R:R:F263	R:R:V259	5.24	No	No	0	5	4
243	R:R:M275	R:R:V260	3.04	No	No	0	5	4
244	R:R:H261	R:R:R272	13.54	Yes	Yes	1	7	6
245	R:R:F263	R:R:R262	7.48	No	Yes	0	5	4
246	R:R:H268	R:R:P269	9.15	No	No	0	5	3
247	R:R:H268	R:R:I270	7.95	No	No	0	5	3
248	R:R:I270	R:R:V274	3.07	No	No	0	3	4
249	R:R:D277	R:R:L281	9.5	No	No	0	6	6
250	R:R:L280	R:R:Y279	14.07	Yes	No	0	7	7
251	R:R:I286	R:R:L282	7.14	No	No	0	7	5
252	R:R:P283	R:R:P284	5.84	No	No	0	8	9
253	R:R:N287	R:R:Y291	6.98	Yes	Yes	2	9	9
254	R:R:I290	R:R:Y291	15.71	Yes	Yes	2	9	9
255	R:R:I290	R:R:K294	4.36	Yes	Yes	2	9	9
256	R:R:G292	R:R:I298	3.53	No	Yes	0	8	7
257	R:R:I298	R:R:T295	6.08	Yes	No	0	7	9
258	R:R:K296	R:R:R299	3.71	No	No	0	6	7
259	R:R:Q297	R:R:R301	7.01	No	Yes	4	6	7
260	R:R:K294	R:R:T239	3	Yes	No	0	9	9
261	R:R:L135	R:R:V134	2.98	Yes	No	0	9	6
262	R:R:L267	R:R:V271	2.98	No	No	0	4	3
263	R:R:N171	R:R:V12	2.96	No	No	0	6	7
264	R:R:L60	R:R:T140	2.95	No	No	0	7	7
265	R:R:I43	R:R:I47	2.94	No	Yes	4	4	5
266	R:R:D277	R:R:V273	2.92	No	No	0	6	6
267	R:R:I244	R:R:L248	2.85	No	No	0	7	4
268	R:R:I255	R:R:L254	2.85	No	Yes	0	3	3
269	R:R:L30	R:R:M77	2.83	No	Yes	0	5	5
270	R:R:L62	R:R:M117	2.83	No	No	0	8	9
271	R:R:Q142	R:R:T138	2.83	No	No	0	2	4
272	R:R:E90	R:R:T10	2.82	No	No	0	4	5
273	R:R:E51	R:R:T50	2.82	No	No	0	7	4
274	R:R:K163	R:R:L97	2.82	No	No	0	3	4
275	R:R:G27	R:R:W85	2.81	No	Yes	0	8	5
276	R:R:A201	R:R:F155	2.77	No	Yes	0	3	5
277	R:R:A56	R:R:Y59	2.67	No	Yes	0	7	9
278	R:R:F101	R:R:S152	2.64	Yes	No	0	5	3
279	R:R:F212	R:R:V208	2.62	No	No	0	4	1
280	R:R:F102	R:R:T98	2.59	No	No	0	4	4
281	R:R:R301	R:R:T300	2.59	Yes	No	0	7	1
282	R:R:V48	R:R:Y59	2.52	No	Yes	0	8	9
283	R:R:M117	R:R:R121	2.48	No	Yes	0	9	9
284	R:R:F212	R:R:L215	2.44	No	No	0	4	3
285	R:R:L83	R:R:R89	2.43	No	No	0	6	5
286	R:R:L225	R:R:R233	2.43	No	No	0	7	7
287	R:R:L62	R:R:Y59	2.34	No	Yes	0	8	9
288	R:R:H127	R:R:R130	2.26	No	No	0	4	6
289	R:R:G18	R:R:P17	2.03	No	Yes	0	4	7
290	R:R:A108	R:R:G151	1.95	No	No	0	4	6
291	R:R:A147	R:R:G144	1.95	No	No	0	6	5
292	R:R:G207	R:R:V210	1.84	No	Yes	0	2	4
293	R:R:G256	R:R:V259	1.84	No	No	0	4	4
294	R:R:G264	R:R:V260	1.84	No	No	0	4	4
295	R:R:A166	R:R:C4	1.81	No	No	0	5	4
296	R:R:A82	R:R:S88	1.71	No	No	0	3	1
297	R:R:A95	R:R:S92	1.71	No	No	0	5	8
298	R:R:A37	R:R:V285	1.7	No	No	0	7	5
299	R:R:A166	R:R:T7	1.68	No	No	0	5	4
300	R:R:L158	R:R:P159	1.64	Yes	No	0	4	4
301	R:R:C240	R:R:I220	1.64	No	Yes	0	9	9
302	R:R:A95	R:R:I91	1.62	No	Yes	0	5	9
303	R:R:S214	R:R:V210	1.62	No	Yes	0	3	4
304	R:R:A249	R:R:I286	1.62	No	No	0	5	7
305	R:R:V285	R:R:V36	1.6	No	No	0	5	3
306	R:R:I103	R:R:S75	1.55	No	No	0	4	5
307	R:R:I43	R:R:V302	1.54	No	No	4	4	6
308	R:R:I47	R:R:V302	1.54	Yes	No	4	5	6
309	R:R:I145	R:R:V149	1.54	No	No	0	3	2
310	R:R:I220	R:R:V224	1.54	Yes	No	0	9	8
311	R:R:H127	R:R:P128	1.53	No	No	0	4	9
312	R:R:M211	R:R:V210	1.52	No	Yes	0	3	4
313	R:R:M275	R:R:V271	1.52	No	No	0	5	3
314	R:R:K235	R:R:T239	1.5	No	No	0	9	9
315	R:R:L192	R:R:V196	1.49	No	No	0	2	2
316	R:R:L227	R:R:V224	1.49	No	No	0	7	8
317	R:R:L165	R:R:T191	1.47	Yes	No	0	7	7
318	R:R:C168	R:R:H169	1.47	No	No	0	9	4
319	R:R:L204	R:R:T200	1.47	No	No	0	3	4
320	R:R:I289	R:R:I290	1.47	No	Yes	0	6	9
321	R:R:N136	R:R:T138	1.46	No	No	0	7	4
322	R:R:F28	R:R:P29	1.44	No	No	0	4	3
323	R:R:E90	R:R:V12	1.43	No	No	0	4	7
324	R:R:C63	R:R:R49	1.39	No	No	0	5	1
325	R:R:E232	R:R:L227	1.33	No	No	0	7	7
326	R:R:H55	R:R:L60	1.29	No	No	0	8	7
327	R:R:F46	R:R:M305	1.24	No	No	0	3	4
328	R:R:L129	R:R:R130	1.21	No	No	0	9	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.3314	7	1	0
2	R:R:F11	5.4425	4	1	9
3	R:R:I16	4.18	4	5	6
4	R:R:P17	4.0975	4	0	7
5	R:R:Y34	7.632	5	3	9
6	R:R:N41	5.795	4	0	9
7	R:R:I47	3.845	4	4	5
8	R:R:Y59	5.545	6	4	9
9	R:R:F61	5.6	5	0	8
10	R:R:I68	4.305	4	0	5
11	R:R:D69	6.78	4	2	9
12	R:R:S73	4.745	4	3	7
13	R:R:M77	6.585	4	3	5
14	R:R:F84	7.31	5	5	4
15	R:R:W85	6.876	5	3	5
16	R:R:I91	3.36	5	1	9
17	R:R:F101	5.302	5	0	5
18	R:R:H104	8.75	4	1	4
19	R:R:E110	6.3225	4	2	8
20	R:R:R121	5.8075	4	2	9
21	R:R:Y122	7.6825	4	0	7
22	R:R:L135	4.64	4	6	9
23	R:R:F155	4.39	6	1	5
24	R:R:L158	7.02667	6	1	4
25	R:R:L165	4.1025	4	1	7
26	R:R:F167	6.045	4	1	7
27	R:R:H175	8.398	5	1	8
28	R:R:Y177	8.785	4	0	5
29	R:R:V179	5.654	5	1	8
30	R:R:H180	10.1117	6	1	6
31	R:R:Q181	8.74167	6	1	4
32	R:R:D182	6.67	4	1	6
33	R:R:N194	5.355	4	1	6
34	R:R:V205	6.325	4	1	4
35	R:R:M206	5.128	5	1	3
36	R:R:D209	8.035	4	1	7
37	R:R:V210	5.345	4	0	4
38	R:R:I220	3.8875	4	0	9
39	R:R:H243	6.10667	6	2	9
40	R:R:F250	7.75	4	0	6
41	R:R:Y251	9.364	5	1	6
42	R:R:L254	7.03	4	0	3
43	R:R:L257	5.065	4	1	5
44	R:R:H261	8.51833	6	1	7
45	R:R:R262	7.09	6	1	4
46	R:R:R272	7.465	4	1	6
47	R:R:L280	8.6675	4	0	7
48	R:R:N287	6.4675	4	2	9
49	R:R:I290	7.478	5	2	9
50	R:R:Y291	8.185	4	2	9
51	R:R:K294	3.5875	4	2	9
52	R:R:I298	5.0275	4	0	7
53	R:R:R301	5.86833	6	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H104	R:R:V179	12.4502	5.54	Yes	Yes	1	4	8
2	R:R:V179	R:R:Y177	22.1217	3.79	Yes	Yes	0	8	5
3	R:R:Q99	R:R:Y177	58.412	3.38	No	Yes	0	9	5
4	R:R:C178	R:R:Q99	57.5041	6.1	No	No	0	9	9
5	R:R:C178	R:R:I91	51.6227	3.27	No	Yes	1	9	9
6	R:R:I91	R:R:L13	50.0665	4.28	Yes	No	0	9	8
7	R:R:L13	R:R:L83	48.8636	4.15	No	No	0	8	6
8	R:R:L83	R:R:R89	26.3009	2.43	No	No	0	6	5
9	R:R:R89	R:R:V12	22.3033	5.23	No	No	0	5	7
10	R:R:N171	R:R:V12	18.2473	2.96	No	No	0	6	7
11	R:R:H8	R:R:N171	16.8823	12.75	No	No	0	3	6
12	R:R:F6	R:R:H8	15.5108	6.79	No	No	0	3	3
13	L:L:?1	R:R:Q181	10.6864	14.32	Yes	Yes	1	0	4
14	R:R:H180	R:R:N194	12.5604	8.93	Yes	Yes	1	6	6
15	R:R:L165	R:R:N194	12.2718	4.12	Yes	Yes	1	7	6
16	R:R:F84	R:R:L83	23.4445	4.87	Yes	No	0	4	6
17	R:R:F84	R:R:I16	13.8346	6.28	Yes	Yes	5	4	6
18	R:R:I16	R:R:P17	12.6836	3.39	Yes	Yes	0	6	7
19	R:R:L280	R:R:Y177	72.9858	10.55	Yes	Yes	0	7	5
20	R:R:L280	R:R:T76	34.1212	5.9	Yes	No	0	7	6
21	R:R:M77	R:R:T76	32.834	3.01	Yes	No	0	5	6
22	R:R:M77	R:R:Y34	20.6173	14.37	Yes	Yes	3	5	9
23	R:R:L81	R:R:Y34	15.4362	4.69	No	Yes	3	8	9
24	R:R:L81	R:R:W85	12.6609	3.42	No	Yes	3	8	5
25	L:L:?1	R:R:I202	18.7628	10.24	Yes	No	0	0	4
26	R:R:I202	R:R:M206	23.0555	4.37	No	Yes	0	4	3
27	R:R:L254	R:R:M206	32.74	9.9	Yes	Yes	0	3	3
28	R:R:F250	R:R:L254	72.4638	3.65	Yes	Yes	0	6	3
29	R:R:E110	R:R:F250	69.04	8.16	Yes	Yes	0	8	6
30	R:R:E110	R:R:N287	96.4044	3.94	Yes	Yes	2	8	9
31	R:R:N287	R:R:Y291	100	6.98	Yes	Yes	2	9	9
32	R:R:H243	R:R:Y291	92.0565	6.53	Yes	Yes	2	9	9
33	R:R:H243	R:R:R121	83.75	3.39	Yes	Yes	2	9	9
34	R:R:M117	R:R:R121	73.2224	2.48	No	Yes	0	9	9
35	R:R:L62	R:R:M117	50.9743	2.83	No	No	0	8	9
36	R:R:L62	R:R:Y59	49.9789	2.34	No	Yes	0	8	9
37	R:R:L54	R:R:Y59	20.8345	11.72	No	Yes	4	9	9
38	R:R:L54	R:R:R301	19.5636	4.86	No	Yes	4	9	7
39	R:R:I47	R:R:R301	21.2398	5.01	Yes	Yes	4	5	7
40	R:R:Q297	R:R:Y59	20.8281	5.64	No	Yes	4	6	9
41	R:R:Q297	R:R:R301	19.7354	7.01	No	Yes	4	6	7
42	R:R:I298	R:R:I47	10.6702	5.89	Yes	Yes	0	7	5
43	R:R:E51	R:R:R301	10.6572	10.47	No	Yes	0	7	7
44	R:R:F61	R:R:M117	26.5214	3.73	Yes	No	0	8	9
45	R:R:F155	R:R:L158	20.3968	8.53	Yes	Yes	1	5	4
46	R:R:E110	R:R:I68	37.0781	4.1	Yes	Yes	0	8	5
47	R:R:L280	R:R:L72	38.6603	4.15	Yes	No	0	7	4
48	R:R:L106	R:R:L72	38.4269	4.15	No	No	0	4	4
49	R:R:L254	R:R:Y279	45.6603	11.72	Yes	No	0	3	7
50	R:R:M206	R:R:S111	11.3932	4.6	Yes	No	1	3	5
51	R:R:I213	R:R:Y251	14.8332	3.63	No	Yes	0	8	6
52	R:R:A118	R:R:I213	12.8522	4.87	No	No	0	8	8
53	R:R:A118	R:R:S216	12.2524	3.42	No	No	0	8	9
54	R:R:I220	R:R:R121	23.2824	5.01	Yes	Yes	0	9	9
55	R:R:S216	R:R:Y122	11.7271	3.82	No	Yes	0	9	7
56	L:L:?1	R:R:R262	14.791	11.62	Yes	Yes	1	0	4
57	R:R:F263	R:R:R262	11.6947	7.48	No	Yes	0	5	4
58	R:R:F263	R:R:V259	10.2552	5.24	No	No	0	5	4
59	R:R:F155	R:R:M206	18.1467	3.73	Yes	Yes	1	5	3
60	R:R:I68	R:R:L106	38.2194	4.28	Yes	No	0	5	4
61	R:R:L280	R:R:Y279	45.0443	14.07	Yes	No	0	7	7
62	R:R:H175	R:R:Y177	13.6627	17.42	Yes	Yes	0	8	5
63	R:R:F250	R:R:Y251	12.1875	13.41	Yes	Yes	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H104	16.9	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L158	6.62	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:H180	18.44	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q181	14.32	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:G198	8.18	1	Yes	No	0	4	0	1
L:L:?1	R:R:I202	10.24	1	Yes	No	0	4	0	1
L:L:?1	R:R:R262	11.62	1	Yes	Yes	0	4	0	1
R:R:I162	R:R:M100	5.83	1	No	No	4	4	2	2
R:R:H180	R:R:M100	5.25	1	Yes	No	6	4	1	2
R:R:H104	R:R:L158	5.14	1	Yes	Yes	4	4	1	1
R:R:H104	R:R:V179	5.54	1	Yes	Yes	4	8	1	2
R:R:H104	R:R:Q181	7.42	1	Yes	Yes	4	4	1	1
R:R:F155	R:R:L158	8.53	1	Yes	Yes	5	4	2	1
R:R:F155	R:R:M206	3.73	1	Yes	Yes	5	3	2	2
R:R:H180	R:R:L158	16.71	1	Yes	Yes	6	4	1	1
R:R:L158	R:R:Y197	3.52	1	Yes	No	4	4	1	2
R:R:H180	R:R:I162	7.95	1	Yes	No	6	4	1	2
R:R:I162	R:R:N194	4.25	1	No	Yes	4	6	2	2
R:R:Q181	R:R:V179	10.03	1	Yes	Yes	4	8	1	2
R:R:H180	R:R:N194	8.93	1	Yes	Yes	6	6	1	2
R:R:H180	R:R:R262	3.39	1	Yes	Yes	6	4	1	1
R:R:L257	R:R:Q181	3.99	1	Yes	Yes	5	4	2	1
R:R:Q181	R:R:S258	4.33	1	Yes	No	4	7	1	2
R:R:H261	R:R:Q181	12.36	1	Yes	Yes	7	4	2	1
R:R:M184	R:R:V195	3.04	1	No	No	4	5	2	2
R:R:M184	R:R:R262	7.44	1	No	Yes	4	4	2	1
R:R:R262	R:R:V195	6.54	1	Yes	No	4	5	1	2
R:R:L199	R:R:R262	6.07	0	No	Yes	4	4	2	1
R:R:I202	R:R:M206	4.37	0	No	Yes	4	3	1	2
R:R:I202	R:R:S258	9.29	0	No	No	4	7	1	2
R:R:H261	R:R:L257	5.14	1	Yes	Yes	7	5	2	2
R:R:F263	R:R:R262	7.48	0	No	Yes	5	4	2	1
R:R:L158	R:R:P159	1.64	1	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F76_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	281
Number of Links	328
Number of Hubs	53
Number of Links mediated by Hubs	186
Number of Communities	6
Number of Nodes involved in Communities	64
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	64658
Length Of Smallest Path	3
Average Path Length	14.646
Length of Longest Path	33
Minimum Path Strength	1.41
Average Path Strength	5.95317
Maximum Path Strength	17.67
Minimum Path Correlation	0.7
Average Path Correlation	0.914039
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	41.7618
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.7932
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • nuclear receptor activity • nuclear steroid receptor activity • DNA-binding transcription factor activity, RNA polymerase II-specific • molecular transducer activity • transcription regulator activity • DNA-binding transcription factor activity • signaling receptor activity • ligand-modulated transcription factor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • olfactory receptor activity • epithelial cell proliferation • melanocyte proliferation • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of systemic arterial blood pressure by hormone • regulation of renal system process • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • positive regulation of renin secretion into blood stream • regulation of endocrine process • renin secretion into blood stream • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of renin secretion into blood stream • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • regulation of blood pressure • endocrine process • regulation of systemic arterial blood pressure • pigment cell differentiation • pigmentation • cellular developmental process • cell differentiation • developmental pigmentation • melanocyte differentiation • positive regulation of blood pressure • hormone-mediated signaling pathway • response to steroid hormone • cellular response to steroid hormone stimulus • steroid hormone receptor signaling pathway • response to fatty acid • cellular response to fatty acid • cell migration • cell motility • endosome membrane • early endosome • endosome • intracellular vesicle • early endosome membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • vesicle membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PPI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PPI
Name	Propanoic acid
Synonyms	Sodium propionate Propionic acid Propanoic acid
Identifier
Formula	C3 H6 O2
Molecular Weight	74.079
SMILES
PubChem	1032
Formal Charge	0
Total Atoms	11
Total Chiral Atoms	0
Total Bonds	10
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H255
Sequence	>8F76_nogp_Chain_R C N F T H A T F V L I G I P G L E K A H F W V G F P L L S M Y V V A M F G N C I V V F I V R T E R S L H A P M Y L F L C M L A A I D L A L S T S T M P K I L A L F W F D S R E I S F E A C L T Q M F F I H A L S A I E S T I L L A M A F D R Y V A I C H P L R H A A V L N N T V T A Q I G I V A V V R G S L F F F P L P L L I K R L A F C H S N V L S H S Y C V H Q D V M K L A Y A D T L P N V V Y G L T A I L L V M G V D V M F I S L S Y F L I I R T V L Q L P S K S E R A K A F G T C V S H I G V V L A F Y V P L I G L S V V H R F G N S L H P I V R V V M G D I Y L L L P P V I N P I I Y G A K T K Q I R T R V L A M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8F76	O1	Odorant	Odorant family 51	OR51E2	Homo sapiens	Propanoic acid	-	Gs/β1/γ2	3.1	2023-03-22	doi.org/10.1038/s41586-023-05798-y
	8F76 (No Gprot)	O1	Odorant	Odorant family 51	OR51E2	Homo sapiens	Propanoic acid	-		3.1	2023-03-22	doi.org/10.1038/s41586-023-05798-y

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