psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C15	7.28	No	No	4	0	0
2	L:L:C1	R:R:M240	3.24	No	No	4	0	4
3	L:L:S2	R:R:Q252	11.55	No	No	0	0	4
4	L:L:S2	R:R:K330	4.59	No	No	0	0	5
5	L:L:C11	L:L:C3	7.28	No	No	0	0	0
6	L:L:M7	L:L:S5	4.6	No	No	0	0	0
7	L:L:L6	R:R:V227	2.98	No	No	0	0	1
8	L:L:D8	L:L:E10	6.5	No	No	0	0	0
9	L:L:D8	R:R:M336	4.16	No	Yes	0	0	1
10	L:L:K9	L:L:Y13	4.78	No	No	0	0	0
11	L:L:K9	R:R:Y68	3.58	No	Yes	6	0	4
12	L:L:K9	R:R:Y231	25.08	No	No	6	0	1
13	L:L:V12	R:R:F229	5.24	No	No	0	0	3
14	L:L:L17	L:L:Y13	8.21	No	No	0	0	0
15	L:L:Y13	R:R:Q72	5.64	No	No	0	0	2
16	L:L:D18	L:L:F14	16.72	Yes	Yes	1	0	0
17	L:L:F14	R:R:K329	3.72	Yes	No	0	0	4
18	L:L:F14	R:R:L344	3.65	Yes	No	0	0	3
19	L:L:F14	R:R:L348	8.53	Yes	Yes	1	0	4
20	L:L:C15	R:R:M240	3.24	No	No	4	0	4
21	L:L:H16	L:L:L17	3.86	No	No	0	0	0
22	L:L:H16	R:R:T238	10.95	No	No	0	0	3
23	L:L:D18	L:L:I19	5.6	Yes	No	1	0	0
24	L:L:D18	R:R:R326	5.96	Yes	Yes	1	0	5
25	L:L:D18	R:R:L348	4.07	Yes	Yes	1	0	4
26	L:L:D18	R:R:D351	11.98	Yes	No	1	0	4
27	L:L:I19	R:R:N137	9.91	No	No	1	0	6
28	L:L:I19	R:R:I355	5.89	No	No	1	0	6
29	L:L:I20	R:R:I136	2.94	No	No	0	0	7
30	L:L:I20	R:R:Q165	4.12	No	No	0	0	7
31	L:L:W21	R:R:K166	9.28	Yes	No	0	0	4
32	L:L:W21	R:R:L259	4.56	Yes	No	0	0	5
33	L:L:W21	R:R:W319	3.75	Yes	Yes	0	0	8
34	L:L:W21	R:R:R326	9	Yes	Yes	0	0	5
35	R:R:H66	R:R:N67	7.65	No	No	0	6	3
36	R:R:Q72	R:R:Y68	7.89	No	Yes	0	2	4
37	R:R:Y231	R:R:Y68	13.9	No	Yes	6	1	4
38	R:R:R232	R:R:Y68	9.26	No	Yes	0	2	4
39	R:R:C69	R:R:P70	3.77	No	No	2	4	2
40	R:R:C69	R:R:K338	4.85	No	No	2	4	2
41	R:R:C69	R:R:R340	8.36	No	Yes	2	4	5
42	R:R:K338	R:R:P70	5.02	No	No	2	2	2
43	R:R:P70	R:R:R340	12.97	No	Yes	2	2	5
44	R:R:Q72	R:R:T73	8.5	No	No	0	2	3
45	R:R:C341	R:R:K74	4.85	No	Yes	1	8	3
46	R:R:K74	R:R:L344	5.64	Yes	No	0	3	3
47	R:R:K74	R:R:S345	6.12	Yes	No	1	3	3
48	R:R:K74	R:R:L348	4.23	Yes	Yes	1	3	4
49	R:R:F79	R:R:L349	7.31	Yes	No	0	3	2
50	R:R:F79	R:R:Y352	5.16	Yes	Yes	0	3	4
51	R:R:F79	R:R:I353	5.02	Yes	No	0	3	5
52	R:R:K80	R:R:Y81	5.97	No	No	0	5	6
53	R:R:N83	R:R:S87	5.96	No	Yes	3	5	6
54	R:R:N83	R:R:Y352	17.44	No	Yes	3	5	4
55	R:R:N356	R:R:N83	5.45	No	No	3	5	5
56	R:R:L142	R:R:T84	5.9	No	No	0	5	5
57	R:R:S87	R:R:V138	3.23	Yes	No	0	6	7
58	R:R:S87	R:R:Y352	3.82	Yes	Yes	3	6	4
59	R:R:N356	R:R:S87	4.47	No	Yes	3	5	6
60	R:R:I90	R:R:T359	6.08	No	No	0	7	7
61	R:R:F91	R:R:M95	6.22	No	No	0	7	6
62	R:R:F91	R:R:P135	7.22	No	No	0	7	8
63	R:R:I92	R:R:M95	2.92	No	No	0	5	6
64	R:R:C363	R:R:V93	3.42	No	No	0	8	6
65	R:R:M95	R:R:V96	3.04	No	No	0	6	4
66	R:R:A123	R:R:N98	3.13	No	Yes	0	9	9
67	R:R:D126	R:R:N98	4.04	Yes	Yes	0	9	9
68	R:R:L127	R:R:N98	4.12	No	Yes	0	8	9
69	R:R:N98	R:R:P366	6.52	Yes	No	0	9	9
70	R:R:I104	R:R:T100	3.04	No	No	0	8	6
71	R:R:I105	R:R:L101	4.28	No	No	0	7	9
72	R:R:A123	R:R:L101	3.15	No	No	0	9	9
73	R:R:F376	R:R:L101	3.65	Yes	No	0	9	9
74	R:R:Q107	R:R:R103	5.84	No	No	0	5	4
75	R:R:A120	R:R:I105	3.25	No	No	0	6	7
76	R:R:Q107	R:R:Y106	3.38	No	No	0	5	3
77	R:R:C110	R:R:N108	4.72	No	No	0	5	5
78	R:R:M111	R:R:N108	14.02	No	No	0	7	5
79	R:R:F376	R:R:M111	4.98	Yes	No	0	9	7
80	R:R:I198	R:R:R112	5.01	Yes	No	0	7	7
81	R:R:N113	R:R:N116	10.9	No	No	0	8	8
82	R:R:G114	R:R:P115	4.06	Yes	No	0	7	8
83	R:R:G114	R:R:T202	5.46	Yes	No	0	7	8
84	R:R:L118	R:R:S121	3	Yes	No	0	8	9
85	R:R:A178	R:R:L118	3.15	No	Yes	0	7	8
86	R:R:L118	R:R:L179	5.54	Yes	No	0	8	9
87	R:R:I119	R:R:L369	4.28	No	No	0	8	9
88	R:R:N175	R:R:S121	7.45	No	No	0	8	9
89	R:R:I206	R:R:S121	4.64	No	No	0	8	9
90	R:R:D126	R:R:L122	4.07	Yes	No	7	9	9
91	R:R:L122	R:R:N175	5.49	No	No	0	9	8
92	R:R:L122	R:R:N365	6.87	No	No	7	9	9
93	R:R:G125	R:R:I128	3.53	No	No	0	8	7
94	R:R:D126	R:R:T172	4.34	Yes	No	0	9	9
95	R:R:D126	R:R:S362	10.31	Yes	No	0	9	9
96	R:R:D126	R:R:N365	4.04	Yes	No	7	9	9
97	R:R:I128	R:R:S168	6.19	No	No	0	7	8
98	R:R:D133	R:R:Y129	8.05	No	Yes	0	7	7
99	R:R:W319	R:R:Y129	6.75	Yes	Yes	0	8	7
100	R:R:L134	R:R:V130	5.96	No	No	0	7	7
101	R:R:F161	R:R:I132	5.02	Yes	No	0	6	6
102	R:R:I132	R:R:L164	4.28	No	No	0	6	5
103	R:R:D133	R:R:N137	8.08	No	No	0	7	6
104	R:R:D133	R:R:Q165	19.58	No	No	0	7	7
105	R:R:L134	R:R:T359	5.9	No	No	0	7	7
106	R:R:F161	R:R:I136	3.77	Yes	No	0	6	7
107	R:R:I355	R:R:N137	5.66	No	No	1	6	6
108	R:R:F139	R:R:P147	11.56	No	No	0	4	6
109	R:R:K140	R:R:W146	4.64	No	Yes	0	5	8
110	R:R:L141	R:R:Y352	22.27	No	Yes	0	5	4
111	R:R:D149	R:R:R145	8.34	Yes	No	0	3	4
112	R:R:P147	R:R:W146	9.46	No	Yes	0	6	8
113	R:R:D149	R:R:W146	4.47	Yes	Yes	0	3	8
114	R:R:C158	R:R:W146	3.92	No	Yes	9	9	8
115	R:R:C239	R:R:W146	18.28	No	Yes	9	9	8
116	R:R:F148	R:R:N151	3.62	Yes	No	0	7	7
117	R:R:F148	R:R:F153	4.29	Yes	No	0	7	7
118	R:R:F148	R:R:G154	4.52	Yes	No	0	7	8
119	R:R:F148	R:R:L157	6.09	Yes	No	0	7	6
120	R:R:D149	R:R:H150	3.78	Yes	No	0	3	3
121	R:R:D149	R:R:K237	4.15	Yes	No	0	3	4
122	R:R:H150	R:R:N151	8.93	No	No	0	3	7
123	R:R:K159	R:R:V155	3.04	Yes	No	0	7	2
124	R:R:F156	R:R:L160	3.65	No	No	0	2	5
125	R:R:F161	R:R:L157	10.96	Yes	No	0	6	6
126	R:R:C158	R:R:C239	5.46	No	No	9	9	9
127	R:R:I222	R:R:K159	5.82	No	Yes	0	4	7
128	R:R:F161	R:R:L160	3.65	Yes	No	0	6	5
129	R:R:E220	R:R:P162	4.72	No	No	10	5	6
130	R:R:F224	R:R:P162	7.22	No	No	10	6	6
131	R:R:F163	R:R:L164	3.65	Yes	No	0	6	5
132	R:R:F163	R:R:F214	5.36	Yes	No	0	6	4
133	R:R:A221	R:R:F163	4.16	No	Yes	0	5	6
134	R:R:E220	R:R:K166	12.15	No	No	0	5	4
135	R:R:F214	R:R:S167	6.61	No	No	0	4	6
136	R:R:V169	R:R:Y263	12.62	No	Yes	0	7	6
137	R:R:V169	R:R:W319	4.9	No	Yes	0	7	8
138	R:R:G170	R:R:S213	3.71	No	No	0	6	8
139	R:R:I171	R:R:W210	14.09	No	Yes	0	8	9
140	R:R:I171	R:R:S213	3.1	No	No	0	8	8
141	R:R:P267	R:R:V173	3.53	No	No	0	9	8
142	R:R:I209	R:R:L174	4.28	No	No	0	7	6
143	R:R:I209	R:R:N175	4.25	No	No	0	7	8
144	R:R:F315	R:R:L176	3.65	Yes	No	0	9	9
145	R:R:C177	R:R:C270	3.64	No	No	0	7	7
146	R:R:L179	R:R:R183	3.64	No	No	0	9	9
147	R:R:S180	R:R:T271	6.4	No	No	11	9	8
148	R:R:S180	R:R:Y275	6.36	No	Yes	11	9	9
149	R:R:F274	R:R:V181	5.24	Yes	No	0	7	6
150	R:R:D182	R:R:R185	7.15	No	No	0	8	5
151	R:R:R183	R:R:Y275	5.14	No	Yes	0	9	9
152	R:R:A188	R:R:Y184	4	No	Yes	12	7	8
153	R:R:F274	R:R:Y184	4.13	Yes	Yes	0	7	8
154	R:R:L277	R:R:Y184	4.69	No	Yes	0	4	8
155	R:R:M278	R:R:Y184	3.59	Yes	Yes	0	8	8
156	R:R:E281	R:R:Y184	12.35	No	Yes	12	4	8
157	R:R:M278	R:R:V187	4.56	Yes	No	0	8	8
158	R:R:A188	R:R:E281	3.02	No	No	12	7	4
159	R:R:R192	R:R:S189	5.27	No	No	0	5	6
160	R:R:S191	R:R:W190	18.53	No	No	0	6	8
161	R:R:G197	R:R:I196	3.53	No	No	0	7	5
162	R:R:I198	R:R:P199	3.39	Yes	No	8	7	3
163	R:R:I198	R:R:T202	3.04	Yes	No	8	7	8
164	R:R:P199	R:R:T202	8.74	No	No	8	3	8
165	R:R:I206	R:R:W210	4.7	No	Yes	0	8	9
166	R:R:F214	R:R:W210	5.01	No	Yes	0	4	9
167	R:R:L212	R:R:L216	5.54	No	No	0	4	5
168	R:R:I215	R:R:I218	2.94	No	No	0	5	5
169	R:R:F262	R:R:L216	4.87	No	No	0	4	5
170	R:R:I218	R:R:P219	6.77	No	No	0	5	9
171	R:R:E220	R:R:F224	4.66	No	No	10	5	6
172	R:R:I222	R:R:M248	2.92	No	Yes	0	4	5
173	R:R:F224	R:R:L241	13.4	No	No	0	6	5
174	R:R:N242	R:R:V225	4.43	No	No	0	3	3
175	R:R:M226	R:R:P228	8.39	No	No	0	6	1
176	R:R:K237	R:R:M226	2.88	No	No	0	4	6
177	R:R:P228	R:R:V227	3.53	No	No	0	1	1
178	R:R:F229	R:R:H236	6.79	No	No	0	3	2
179	R:R:F229	R:R:T238	5.19	No	No	0	3	3
180	R:R:E230	R:R:Q235	12.74	No	No	0	2	4
181	R:R:E234	R:R:H236	8.62	No	No	0	2	2
182	R:R:M240	R:R:T238	6.02	No	No	0	4	3
183	R:R:L241	R:R:Q252	3.99	No	No	0	5	4
184	R:R:N242	R:R:T244	2.92	No	No	0	3	5
185	R:R:A243	R:R:M248	3.22	No	Yes	0	5	5
186	R:R:M248	R:R:S245	3.07	Yes	No	0	5	2
187	R:R:E249	R:R:K246	9.45	No	No	0	1	3
188	R:R:K255	R:R:Y251	9.55	No	No	0	6	3
189	R:R:W258	R:R:Y251	4.82	No	No	0	4	3
190	R:R:D256	R:R:K255	5.53	No	No	0	5	6
191	R:R:D256	R:R:R326	8.34	No	Yes	0	5	5
192	R:R:D256	R:R:K330	6.91	No	No	0	5	5
193	R:R:I327	R:R:W257	7.05	No	No	0	5	4
194	R:R:L259	R:R:W258	4.56	No	No	0	5	4
195	R:R:F262	R:R:W258	4.01	No	No	0	4	4
196	R:R:L259	R:R:Y263	11.72	No	Yes	0	5	6
197	R:R:F260	R:R:G261	3.01	No	No	0	6	4
198	R:R:F260	R:R:F264	8.57	No	No	13	6	8
199	R:R:F260	R:R:H323	7.92	No	No	13	6	7
200	R:R:C265	R:R:G261	3.92	No	No	0	4	4
201	R:R:F262	R:R:Y263	4.13	No	Yes	0	4	6
202	R:R:H323	R:R:Y263	8.71	No	Yes	0	7	6
203	R:R:F264	R:R:F320	7.5	No	No	0	8	6
204	R:R:F264	R:R:H323	12.44	No	No	13	8	7
205	R:R:M266	R:R:P267	10.06	No	No	0	5	9
206	R:R:A316	R:R:L268	4.73	No	No	0	6	7
207	R:R:T271	R:R:Y275	6.24	No	Yes	11	8	9
208	R:R:T271	R:R:V312	4.76	No	No	0	8	8
209	R:R:F274	R:R:I273	5.02	Yes	No	0	7	3
210	R:R:V308	R:R:Y275	10.09	No	Yes	0	8	9
211	R:R:F309	R:R:Y275	3.09	No	Yes	0	5	9
212	R:R:F309	R:R:T276	3.89	No	No	0	5	3
213	R:R:M278	R:R:M282	2.89	Yes	No	0	8	8
214	R:R:A305	R:R:T279	3.36	No	No	0	7	6
215	R:R:C280	R:R:E281	3.04	No	No	0	4	4
216	R:R:M282	R:R:R301	9.93	No	No	0	8	7
217	R:R:L283	R:R:R302	12.15	No	No	0	5	5
218	R:R:E296	R:R:H297	3.69	No	No	0	1	4
219	R:R:K299	R:R:Q300	4.07	No	No	14	5	7
220	R:R:E303	R:R:K299	8.1	No	No	14	8	5
221	R:R:E303	R:R:Q300	10.19	No	No	14	8	7
222	R:R:R301	R:R:R302	3.2	No	No	0	7	5
223	R:R:F315	R:R:W319	6.01	Yes	Yes	0	9	8
224	R:R:F315	R:R:N361	7.25	Yes	No	0	9	9
225	R:R:C318	R:R:M360	3.24	No	No	0	9	5
226	R:R:C318	R:R:N361	6.3	No	No	0	9	9
227	R:R:L322	R:R:W319	5.69	No	Yes	0	6	8
228	R:R:A358	R:R:W319	9.08	No	Yes	0	7	8
229	R:R:F320	R:R:P321	2.89	No	No	0	6	9
230	R:R:F320	R:R:L324	10.96	No	No	0	6	6
231	R:R:G354	R:R:P321	4.06	No	No	0	7	9
232	R:R:I355	R:R:L322	2.85	No	No	0	6	6
233	R:R:K329	R:R:S325	3.06	No	No	0	4	5
234	R:R:M350	R:R:S325	4.6	No	No	0	5	5
235	R:R:D351	R:R:S325	8.83	No	No	0	4	5
236	R:R:K329	R:R:R326	13.61	No	Yes	0	4	5
237	R:R:D351	R:R:R326	8.34	No	Yes	1	4	5
238	R:R:L328	R:R:T331	2.95	No	No	15	5	4
239	R:R:L328	R:R:V332	4.47	No	No	15	5	4
240	R:R:T331	R:R:V332	6.35	No	No	15	4	4
241	R:R:M336	R:R:Y333	4.79	Yes	No	5	1	3
242	R:R:N339	R:R:Y333	4.65	No	No	5	2	3
243	R:R:L344	R:R:Y333	3.52	No	No	0	3	3
244	R:R:D337	R:R:E335	5.2	No	No	0	1	1
245	R:R:M336	R:R:N339	4.21	Yes	No	5	1	2
246	R:R:K338	R:R:R340	7.43	No	Yes	2	2	5
247	R:R:L343	R:R:N339	6.87	No	No	0	2	2
248	R:R:E342	R:R:R340	3.49	No	Yes	0	1	5
249	R:R:C341	R:R:S345	3.44	No	No	1	8	3
250	R:R:L343	R:R:L347	4.15	No	No	0	2	4
251	R:R:F346	R:R:M350	4.98	No	No	0	3	5
252	R:R:I353	R:R:L357	2.85	No	No	0	5	7
253	R:R:G354	R:R:L357	5.13	No	No	0	7	7
254	R:R:I364	R:R:M360	5.83	No	No	0	6	5
255	R:R:I364	R:R:I367	4.42	No	No	0	6	7
256	R:R:F376	R:R:L369	3.65	Yes	No	0	9	9
257	R:R:F371	R:R:Y370	4.13	No	No	0	6	7
258	R:R:K374	R:R:Y370	8.36	No	No	0	6	7
259	R:R:S373	R:R:V372	3.23	No	No	0	9	7
260	R:R:I104	R:R:N108	2.83	No	No	0	8	5
261	R:R:I314	R:R:N361	2.83	No	No	0	6	9
262	R:R:C270	R:R:F274	2.79	No	Yes	0	7	7
263	R:R:A217	R:R:F163	2.77	No	Yes	0	7	6
264	R:R:L328	R:R:L347	2.77	No	No	0	5	4
265	R:R:K109	R:R:Q107	2.71	No	No	0	6	5
266	R:R:D182	R:R:L118	2.71	No	Yes	0	8	8
267	R:R:E335	R:R:M336	2.71	No	Yes	0	1	1
268	R:R:F315	R:R:V173	2.62	Yes	No	0	9	8
269	R:R:D253	R:R:Q252	2.61	No	No	0	3	4
270	R:R:F79	R:R:T76	2.59	Yes	No	0	3	3
271	R:R:S77	R:R:Y81	2.54	No	No	0	2	6
272	R:R:S168	R:R:Y129	2.54	No	Yes	0	8	7
273	R:R:T359	R:R:Y129	2.5	No	Yes	0	7	7
274	R:R:F91	R:R:L134	2.44	No	No	0	7	7
275	R:R:F315	R:R:L268	2.44	Yes	No	0	9	7
276	R:R:F376	R:R:N116	2.42	Yes	No	0	9	8
277	R:R:M278	R:R:Y275	2.39	Yes	Yes	0	8	9
278	R:R:Q194	R:R:R192	2.34	No	No	0	5	5
279	R:R:N67	R:R:Y231	2.33	No	No	0	3	1
280	R:R:K330	R:R:W257	2.32	No	No	0	5	4
281	R:R:L124	R:R:W210	2.28	No	Yes	0	7	9
282	L:L:E10	R:R:Y68	2.24	No	Yes	0	0	4
283	R:R:A117	R:R:G114	1.95	No	Yes	0	5	7
284	R:R:G94	R:R:V93	1.84	No	No	0	8	6
285	R:R:G97	R:R:V96	1.84	No	No	0	9	4
286	L:L:C11	L:L:C15	1.82	No	No	0	0	0
287	R:R:G223	R:R:M248	1.75	No	Yes	0	5	5
288	L:L:L17	R:R:G144	1.71	No	No	0	0	4
289	R:R:G114	R:R:N113	1.7	Yes	No	0	7	8
290	R:R:A78	R:R:T76	1.68	No	No	0	1	3
291	R:R:E230	R:R:G233	1.64	No	No	0	2	4
292	R:R:E234	R:R:G233	1.64	No	No	0	2	4
293	R:R:C310	R:R:I314	1.64	No	No	0	6	6
294	R:R:C158	R:R:K159	1.62	No	Yes	0	9	7
295	R:R:A203	R:R:I198	1.62	No	Yes	0	3	7
296	R:R:V304	R:R:V308	1.6	No	No	0	7	8
297	R:R:T307	R:R:V372	1.59	No	No	0	8	7
298	R:R:A120	R:R:L102	1.58	No	No	0	6	7
299	R:R:A123	R:R:L102	1.58	No	No	0	9	7
300	R:R:A368	R:R:L311	1.58	No	No	0	8	8
301	R:R:I86	R:R:S87	1.55	No	Yes	0	5	6
302	R:R:I86	R:R:V85	1.54	No	No	0	5	6
303	R:R:I132	R:R:V131	1.54	No	No	0	6	6
304	R:R:I204	R:R:V207	1.54	No	No	0	4	4
305	R:R:I206	R:R:V207	1.54	No	No	0	8	4
306	R:R:K375	R:R:S373	1.53	No	No	0	7	9
307	R:R:K159	R:R:V225	1.52	Yes	No	0	7	3
308	R:R:A186	R:R:Q194	1.52	No	No	0	9	5
309	R:R:A243	R:R:E249	1.51	No	No	0	5	1
310	R:R:M278	R:R:T279	1.51	Yes	No	0	8	6
311	R:R:K80	R:R:T84	1.5	No	No	0	5	5
312	R:R:L317	R:R:V313	1.49	No	No	0	6	5
313	R:R:I211	R:R:I215	1.47	No	No	0	4	5
314	R:R:E296	R:R:S295	1.44	No	No	0	1	3
315	R:R:K374	R:R:K377	1.44	No	No	0	6	8
316	R:R:I75	R:R:L141	1.43	No	No	0	2	5
317	R:R:I75	R:R:L348	1.43	No	Yes	0	2	4
318	R:R:I314	R:R:L311	1.43	No	No	0	6	8
319	R:R:I196	R:R:N113	1.42	No	No	0	5	8
320	R:R:K377	R:R:N378	1.4	No	No	0	8	5
321	R:R:L283	R:R:L298	1.38	No	No	0	5	4
322	R:R:R185	R:R:S189	1.32	No	No	0	5	6
323	R:R:R192	R:R:S191	1.32	No	No	0	5	6
324	R:R:F247	R:R:S245	1.32	No	No	0	4	2
325	R:R:I104	R:R:R103	1.25	No	No	0	8	4
326	R:R:V254	R:R:W257	1.23	No	No	0	4	4
327	R:R:H297	R:R:R301	1.13	No	No	0	4	7
328	R:R:F376	R:R:Y370	1.03	Yes	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F14	8.155	4	1	0
2	L:L:D18	8.866	5	1	0
3	L:L:W21	6.6475	4	0	0
4	R:R:Y68	7.374	5	6	4
5	R:R:K74	5.21	4	1	3
6	R:R:F79	5.02	4	0	3
7	R:R:S87	3.806	5	3	6
8	R:R:N98	4.4525	4	0	9
9	R:R:G114	3.2925	4	0	7
10	R:R:L118	3.6	4	0	8
11	R:R:D126	5.36	5	7	9
12	R:R:Y129	4.96	4	0	7
13	R:R:W146	8.154	5	9	8
14	R:R:F148	4.63	4	0	7
15	R:R:D149	5.185	4	0	3
16	R:R:K159	3	4	0	7
17	R:R:F161	5.85	4	0	6
18	R:R:F163	3.985	4	0	6
19	R:R:Y184	5.752	5	12	8
20	R:R:I198	3.265	4	8	7
21	R:R:W210	6.52	4	0	9
22	R:R:M248	2.74	4	0	5
23	R:R:Y263	9.295	4	0	6
24	R:R:F274	4.295	4	0	7
25	R:R:Y275	5.55167	6	11	9
26	R:R:M278	2.988	5	0	8
27	R:R:F315	4.394	5	0	9
28	R:R:W319	6.03	6	0	8
29	R:R:R326	9.05	5	1	5
30	R:R:M336	3.9675	4	5	1
31	R:R:R340	8.0625	4	2	5
32	R:R:L348	4.565	4	1	4
33	R:R:Y352	12.1725	4	3	4
34	R:R:F376	3.146	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M240	R:R:T238	15.2986	6.02	No	No	0	4	3
2	L:L:H16	R:R:T238	39.6972	10.95	No	No	0	0	3
3	L:L:H16	L:L:L17	42.7082	3.86	No	No	0	0	0
4	L:L:L17	L:L:Y13	48.6754	8.21	No	No	0	0	0
5	L:L:K9	L:L:Y13	25.9125	4.78	No	No	0	0	0
6	L:L:K9	R:R:Y68	27.1531	3.58	No	Yes	6	0	4
7	L:L:E10	R:R:Y68	62.8974	2.24	No	Yes	0	0	4
8	L:L:D8	L:L:E10	64.222	6.5	No	No	0	0	0
9	L:L:D8	R:R:M336	65.5383	4.16	No	Yes	0	0	1
10	R:R:M336	R:R:Y333	68.2506	4.79	Yes	No	5	1	3
11	R:R:L344	R:R:Y333	78.238	3.52	No	No	0	3	3
12	L:L:F14	R:R:L344	74.4365	3.65	Yes	No	0	0	3
13	L:L:D18	L:L:F14	54.6636	16.72	Yes	Yes	1	0	0
14	L:L:D18	R:R:R326	27.9226	5.96	Yes	Yes	1	0	5
15	R:R:D256	R:R:R326	19.2809	8.34	No	Yes	0	5	5
16	R:R:D256	R:R:K330	14.8949	6.91	No	No	0	5	5
17	L:L:Y13	R:R:Q72	25.7611	5.64	No	No	0	0	2
18	R:R:Q72	R:R:Y68	28.6712	7.89	No	Yes	0	2	4
19	L:L:F14	R:R:K329	17.8806	3.72	Yes	No	0	0	4
20	R:R:K329	R:R:R326	18.3726	13.61	No	Yes	0	4	5
21	L:L:D18	L:L:I19	61.7872	5.6	Yes	No	1	0	0
22	L:L:I19	R:R:N137	61.2195	9.91	No	No	1	0	6
23	R:R:D133	R:R:N137	62.868	8.08	No	No	0	7	6
24	R:R:D133	R:R:Q165	100	19.58	No	No	0	7	7
25	L:L:I20	R:R:Q165	99.8865	4.12	No	No	0	0	7
26	L:L:I20	R:R:I136	99.7645	2.94	No	No	0	0	7
27	R:R:F161	R:R:I136	99.6341	3.77	Yes	No	0	6	7
28	R:R:F161	R:R:L157	37.4054	10.96	Yes	No	0	6	6
29	R:R:F148	R:R:L157	36.3667	6.09	Yes	No	0	7	6
30	R:R:F148	R:R:N151	33.2002	3.62	Yes	No	0	7	7
31	R:R:H150	R:R:N151	32.1278	8.93	No	No	0	3	7
32	R:R:D149	R:R:H150	31.0471	3.78	Yes	No	0	3	3
33	R:R:F229	R:R:T238	21.6232	5.19	No	No	0	3	3
34	L:L:W21	R:R:R326	41.0723	9	Yes	Yes	0	0	5
35	L:L:W21	R:R:L259	12.767	4.56	Yes	No	0	0	5
36	L:L:W21	R:R:W319	35.7065	3.75	Yes	Yes	0	0	8
37	R:R:I75	R:R:L348	23.8267	1.43	No	Yes	0	2	4
38	R:R:I75	R:R:L141	22.4348	1.43	No	No	0	2	5
39	R:R:L141	R:R:Y352	21.0555	22.27	No	Yes	0	5	4
40	R:R:D133	R:R:Y129	46.8713	8.05	No	Yes	0	7	7
41	R:R:T359	R:R:Y129	17.7839	2.5	No	Yes	0	7	7
42	R:R:W319	R:R:Y129	45.3995	6.75	Yes	Yes	0	8	7
43	R:R:L134	R:R:T359	14.2935	5.9	No	No	0	7	7
44	R:R:F91	R:R:L134	10.7696	2.44	No	No	0	7	7
45	R:R:F161	R:R:I132	89.7729	5.02	Yes	No	0	6	6
46	R:R:I132	R:R:L164	88.8982	4.28	No	No	0	6	5
47	R:R:F163	R:R:L164	88.4483	3.65	Yes	No	0	6	5
48	R:R:F163	R:R:F214	87.0479	5.36	Yes	No	0	6	4
49	R:R:F214	R:R:W210	86.0723	5.01	No	Yes	0	4	9
50	R:R:I206	R:R:W210	83.4861	4.7	No	Yes	0	8	9
51	R:R:I206	R:R:S121	81.8335	4.64	No	No	0	8	9
52	R:R:N175	R:R:S121	50.0042	7.45	No	No	0	8	9
53	R:R:L122	R:R:N175	47.1909	5.49	No	No	0	9	8
54	R:R:D126	R:R:L122	45.1051	4.07	Yes	No	7	9	9
55	R:R:D126	R:R:N98	42.3339	4.04	Yes	Yes	0	9	9
56	R:R:A123	R:R:N98	39.3188	3.13	No	Yes	0	9	9
57	R:R:A123	R:R:L101	36.0934	3.15	No	No	0	9	9
58	R:R:F376	R:R:L101	34.1127	3.65	Yes	No	0	9	9
59	R:R:F376	R:R:M111	11.3204	4.98	Yes	No	0	9	7
60	R:R:M111	R:R:N108	10.1556	14.02	No	No	0	7	5
61	R:R:F376	R:R:N116	14.9916	2.42	Yes	No	0	9	8
62	R:R:N113	R:R:N116	13.8267	10.9	No	No	0	8	8
63	R:R:G114	R:R:N113	10.1556	1.7	Yes	No	0	7	8
64	R:R:L118	R:R:S121	47.0521	3	Yes	No	0	8	9
65	R:R:D149	R:R:W146	23.2464	4.47	Yes	Yes	0	3	8
66	R:R:C158	R:R:W146	17.3633	3.92	No	Yes	9	9	8
67	R:R:C158	R:R:K159	16.2321	1.62	No	Yes	0	9	7
68	R:R:I222	R:R:K159	10.1556	5.82	No	Yes	0	4	7
69	R:R:V169	R:R:W319	12.1236	4.9	No	Yes	0	7	8
70	R:R:F315	R:R:W319	22.8301	6.01	Yes	Yes	0	9	8
71	R:R:L118	R:R:L179	37.1909	5.54	Yes	No	0	8	9
72	R:R:L179	R:R:R183	36.1733	3.64	No	No	0	9	9
73	R:R:R183	R:R:Y275	35.1598	5.14	No	Yes	0	9	9
74	R:R:M278	R:R:Y275	26.6232	2.39	Yes	Yes	0	8	9
75	R:R:M278	R:R:Y184	12.6114	3.59	Yes	Yes	0	8	8
76	R:R:D182	R:R:L118	10.0505	2.71	No	Yes	0	8	8
77	R:R:F229	R:R:H236	15.513	6.79	No	No	0	3	2
78	R:R:E234	R:R:H236	12.4264	8.62	No	No	0	2	2
79	R:R:H323	R:R:Y263	13.2717	8.71	No	Yes	0	7	6
80	R:R:M278	R:R:M282	10.1388	2.89	Yes	No	0	8	8
81	R:R:F315	R:R:N361	13.0572	7.25	Yes	No	0	9	9
82	L:L:D18	R:R:L348	18.7553	4.07	Yes	Yes	1	0	4
83	R:R:V169	R:R:Y263	10.8158	12.62	No	Yes	0	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:M240	3.24	4	No	No	0	4	0	1
L:L:S2	R:R:Q252	11.55	0	No	No	0	4	0	1
L:L:S2	R:R:K330	4.59	0	No	No	0	5	0	1
L:L:L6	R:R:V227	2.98	0	No	No	0	1	0	1
L:L:D8	R:R:M336	4.16	0	No	Yes	0	1	0	1
L:L:K9	R:R:Y68	3.58	6	No	Yes	0	4	0	1
L:L:K9	R:R:Y231	25.08	6	No	No	0	1	0	1
L:L:V12	R:R:F229	5.24	0	No	No	0	3	0	1
L:L:Y13	R:R:Q72	5.64	0	No	No	0	2	0	1
L:L:F14	R:R:K329	3.72	1	Yes	No	0	4	0	1
L:L:F14	R:R:L344	3.65	1	Yes	No	0	3	0	1
L:L:F14	R:R:L348	8.53	1	Yes	Yes	0	4	0	1
L:L:C15	R:R:M240	3.24	4	No	No	0	4	0	1
L:L:H16	R:R:T238	10.95	0	No	No	0	3	0	1
L:L:D18	R:R:R326	5.96	1	Yes	Yes	0	5	0	1
L:L:D18	R:R:L348	4.07	1	Yes	Yes	0	4	0	1
L:L:D18	R:R:D351	11.98	1	Yes	No	0	4	0	1
L:L:I19	R:R:N137	9.91	1	No	No	0	6	0	1
L:L:I19	R:R:I355	5.89	1	No	No	0	6	0	1
L:L:I20	R:R:I136	2.94	0	No	No	0	7	0	1
L:L:I20	R:R:Q165	4.12	0	No	No	0	7	0	1
L:L:W21	R:R:K166	9.28	0	Yes	No	0	4	0	1
L:L:W21	R:R:L259	4.56	0	Yes	No	0	5	0	1
L:L:W21	R:R:W319	3.75	0	Yes	Yes	0	8	0	1
L:L:W21	R:R:R326	9	0	Yes	Yes	0	5	0	1
R:R:Q72	R:R:Y68	7.89	0	No	Yes	2	4	1	1
R:R:Y231	R:R:Y68	13.9	6	No	Yes	1	4	1	1
R:R:R232	R:R:Y68	9.26	0	No	Yes	2	4	2	1
R:R:Q72	R:R:T73	8.5	0	No	No	2	3	1	2
R:R:K74	R:R:L344	5.64	1	Yes	No	3	3	2	1
R:R:K74	R:R:L348	4.23	1	Yes	Yes	3	4	2	1
R:R:D133	R:R:Y129	8.05	0	No	Yes	7	7	2	2
R:R:W319	R:R:Y129	6.75	0	Yes	Yes	8	7	1	2
R:R:D133	R:R:N137	8.08	0	No	No	7	6	2	1
R:R:D133	R:R:Q165	19.58	0	No	No	7	7	2	1
R:R:F161	R:R:I136	3.77	0	Yes	No	6	7	2	1
R:R:I355	R:R:N137	5.66	1	No	No	6	6	1	1
R:R:E220	R:R:K166	12.15	10	No	No	5	4	2	1
R:R:V169	R:R:Y263	12.62	0	No	Yes	7	6	2	2
R:R:V169	R:R:W319	4.9	0	No	Yes	7	8	2	1
R:R:P228	R:R:V227	3.53	0	No	No	1	1	2	1
R:R:F229	R:R:H236	6.79	0	No	No	3	2	1	2
R:R:F229	R:R:T238	5.19	0	No	No	3	3	1	1
R:R:M240	R:R:T238	6.02	4	No	No	4	3	1	1
R:R:L241	R:R:Q252	3.99	0	No	No	5	4	2	1
R:R:D256	R:R:R326	8.34	0	No	Yes	5	5	2	1
R:R:D256	R:R:K330	6.91	0	No	No	5	5	2	1
R:R:L259	R:R:W258	4.56	0	No	No	5	4	1	2
R:R:L259	R:R:Y263	11.72	0	No	Yes	5	6	1	2
R:R:F315	R:R:W319	6.01	0	Yes	Yes	9	8	2	1
R:R:L322	R:R:W319	5.69	0	No	Yes	6	8	2	1
R:R:A358	R:R:W319	9.08	0	No	Yes	7	8	2	1
R:R:I355	R:R:L322	2.85	1	No	No	6	6	1	2
R:R:K329	R:R:S325	3.06	0	No	No	4	5	1	2
R:R:D351	R:R:S325	8.83	1	No	No	4	5	1	2
R:R:K329	R:R:R326	13.61	0	No	Yes	4	5	1	1
R:R:D351	R:R:R326	8.34	1	No	Yes	4	5	1	1
R:R:M336	R:R:Y333	4.79	5	Yes	No	1	3	1	2
R:R:N339	R:R:Y333	4.65	5	No	No	2	3	2	2
R:R:L344	R:R:Y333	3.52	0	No	No	3	3	1	2
R:R:M336	R:R:N339	4.21	5	Yes	No	1	2	1	2
R:R:E335	R:R:M336	2.71	0	No	Yes	1	1	2	1
R:R:D253	R:R:Q252	2.61	0	No	No	3	4	2	1
R:R:N67	R:R:Y231	2.33	0	No	No	3	1	2	1
R:R:K330	R:R:W257	2.32	0	No	No	5	4	1	2
L:L:E10	R:R:Y68	2.24	0	No	Yes	0	4	0	1
L:L:L17	R:R:G144	1.71	0	No	No	0	4	0	1
R:R:I75	R:R:L348	1.43	0	No	Yes	2	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HCQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	304
Number of Links	328
Number of Hubs	34
Number of Links mediated by Hubs	134
Number of Communities	15
Number of Nodes involved in Communities	55
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	51227
Length Of Smallest Path	3
Average Path Length	18.9846
Length of Longest Path	46
Minimum Path Strength	1.42
Average Path Strength	5.79939
Maximum Path Strength	19.855
Minimum Path Correlation	0.7
Average Path Correlation	0.934383
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	47.0635
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.9911
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25101
Sequence	>8HCQ_nogp_Chain_R H N Y C P Q Q T K I T S A F K Y I N T V I S C T I F I V G M V G N A T L L R I I Y Q N K C M R N G P N A L I A S L A L G D L I Y V V I D L P I N V F K L L A G R W P F D H N D F G V F L C K L F P F L Q K S S V G I T V L N L C A L S V D R Y R A V A S W S R V Q G I G I P L V T A I E I V S I W I L S F I L A I P E A I G F V M V P F E Y R G E Q H K T C M L N A T S K F M E F Y Q D V K D W W L F G F Y F C M P L V C T A I F Y T L M T C E M L N L S E H L K Q R R E V A K T V F C L V V I F A L C W F P L H L S R I L K K T V Y E M D K N R C E L L S F L L L M D Y I G I N L A T M N S C I N P I A L Y F V S K K F K N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HCQ	A	Peptide	Endothelin	ET_A	Homo sapiens	Endothelin-1	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.01	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8HCQ (No Gprot)	A	Peptide	Endothelin	ET_A	Homo sapiens	Endothelin-1	-		3.01	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8XVI	A	Peptide	Endothelin	ET_A	Homo sapiens	Endothelin-1	-	chim(Gs-CtGq)/β1/γ2	3.32	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVI (No Gprot)	A	Peptide	Endothelin	ET_A	Homo sapiens	Endothelin-1	-		3.32	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVJ	A	Peptide	Endothelin	ET_A	Homo sapiens	Macitentan	-	-	3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVK	A	Peptide	Endothelin	ET_A	Homo sapiens	Ambrisentan	-	-	3.21	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVL	A	Peptide	Endothelin	ET_A	Homo sapiens	Zibotentan	-	-	3.22	2024-08-28	doi.org/10.1038/s41421-024-00705-9

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