psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y231	R:R:Y68	6.95	Yes	No	4	1	4
2	R:R:R232	R:R:Y68	4.12	Yes	No	4	2	4
3	R:R:C69	R:R:P70	3.77	No	No	0	4	2
4	R:R:C341	R:R:C69	7.28	No	No	0	8	4
5	L:L:E10	R:R:C69	4.56	No	No	0	0	4
6	R:R:K74	R:R:Q72	6.78	No	No	0	3	2
7	R:R:Q72	R:R:R232	4.67	No	Yes	0	2	2
8	L:L:Y13	R:R:Q72	5.64	No	No	0	0	2
9	R:R:C341	R:R:T73	3.38	No	No	0	8	3
10	R:R:S345	R:R:T73	3.2	No	No	0	3	3
11	R:R:F79	R:R:I75	2.51	Yes	Yes	1	3	2
12	R:R:I75	R:R:K80	4.36	Yes	No	0	2	5
13	R:R:I75	R:R:L348	5.71	Yes	No	0	2	4
14	R:R:I75	R:R:L349	2.85	Yes	No	1	2	2
15	R:R:S77	R:R:Y81	3.82	No	No	0	2	6
16	R:R:F79	R:R:N83	16.92	Yes	Yes	1	3	5
17	R:R:F79	R:R:L349	17.05	Yes	No	1	3	2
18	R:R:F79	R:R:Y352	7.22	Yes	Yes	1	3	4
19	R:R:N83	R:R:Y352	3.49	Yes	Yes	1	5	4
20	R:R:N356	R:R:N83	8.17	No	Yes	0	5	5
21	R:R:T84	R:R:V138	3.17	No	No	0	5	7
22	R:R:L134	R:R:S87	3	No	No	0	7	6
23	R:R:N356	R:R:S87	4.47	No	No	0	5	6
24	R:R:I90	R:R:T359	9.12	No	No	0	7	7
25	R:R:I90	R:R:M360	2.92	No	No	0	7	5
26	R:R:F91	R:R:M95	6.22	No	No	0	7	6
27	R:R:I92	R:R:V93	3.07	No	No	0	5	6
28	R:R:C363	R:R:V93	3.42	No	No	0	8	6
29	R:R:L127	R:R:M95	4.24	No	No	0	8	6
30	R:R:M95	R:R:V131	3.04	No	No	0	6	6
31	R:R:G97	R:R:V96	3.68	No	No	0	9	4
32	R:R:A123	R:R:N98	3.13	No	No	0	9	9
33	R:R:D126	R:R:N98	5.39	Yes	No	0	9	9
34	R:R:L127	R:R:N98	5.49	No	No	0	8	9
35	R:R:F380	R:R:T100	2.59	No	No	0	7	6
36	R:R:I105	R:R:L101	2.85	No	Yes	0	7	9
37	R:R:I119	R:R:L101	4.28	No	Yes	0	8	9
38	R:R:F376	R:R:L101	2.44	Yes	Yes	0	9	9
39	R:R:R103	R:R:Y106	3.09	No	No	0	4	3
40	R:R:I104	R:R:Q107	4.12	No	No	0	8	5
41	R:R:C379	R:R:I104	3.27	No	No	0	6	8
42	R:R:I105	R:R:N116	4.25	No	No	0	7	8
43	R:R:A120	R:R:I105	3.25	No	No	0	6	7
44	R:R:N108	R:R:Q107	3.96	No	No	0	5	5
45	R:R:C110	R:R:N108	6.3	No	No	0	5	5
46	R:R:M111	R:R:N108	5.61	No	No	0	7	5
47	R:R:M111	R:R:N116	9.82	No	No	0	7	8
48	R:R:G197	R:R:R112	4.5	No	No	0	7	7
49	R:R:I198	R:R:R112	11.27	No	No	0	7	7
50	R:R:N113	R:R:P115	6.52	No	No	0	8	8
51	R:R:N113	R:R:N116	10.9	No	No	0	8	8
52	R:R:G114	R:R:P115	4.06	No	No	0	7	8
53	R:R:L118	R:R:L179	5.54	No	No	0	8	9
54	R:R:D182	R:R:L118	5.43	Yes	No	0	8	8
55	R:R:N175	R:R:S121	8.94	No	No	0	8	9
56	R:R:I206	R:R:S121	3.1	No	No	0	8	9
57	R:R:S121	R:R:W210	3.71	No	Yes	0	9	9
58	R:R:D126	R:R:L122	4.07	Yes	Yes	5	9	9
59	R:R:L122	R:R:T172	2.95	Yes	No	5	9	9
60	R:R:L122	R:R:N175	4.12	Yes	No	0	9	8
61	R:R:L122	R:R:L176	2.77	Yes	No	0	9	9
62	R:R:L122	R:R:N365	2.75	Yes	No	0	9	9
63	R:R:L124	R:R:W210	5.69	No	Yes	0	7	9
64	R:R:G125	R:R:I171	3.53	No	No	0	8	8
65	R:R:D126	R:R:T172	8.67	Yes	No	5	9	9
66	R:R:D126	R:R:S362	7.36	Yes	No	0	9	9
67	R:R:I128	R:R:S168	6.19	No	No	0	7	8
68	R:R:D133	R:R:Y129	25.29	No	Yes	6	7	7
69	R:R:Q165	R:R:Y129	3.38	No	Yes	6	7	7
70	R:R:S168	R:R:Y129	6.36	No	Yes	0	8	7
71	R:R:V169	R:R:Y129	3.79	No	Yes	0	7	7
72	R:R:A358	R:R:Y129	4	No	Yes	0	7	7
73	R:R:S362	R:R:V130	3.23	No	No	0	9	7
74	R:R:D133	R:R:I132	2.8	No	No	0	7	6
75	R:R:I132	R:R:L164	5.71	No	No	0	6	5
76	R:R:D133	R:R:Q165	18.27	No	No	6	7	7
77	R:R:L134	R:R:T359	4.42	No	No	0	7	7
78	R:R:I136	R:R:N137	2.83	No	No	0	7	6
79	R:R:I136	R:R:W146	3.52	No	Yes	0	7	8
80	R:R:F161	R:R:I136	8.79	No	No	0	6	7
81	R:R:I355	R:R:N137	5.66	No	No	0	6	6
82	L:L:I20	R:R:N137	2.83	Yes	No	0	0	6
83	R:R:A143	R:R:F139	4.16	No	No	0	5	4
84	R:R:F139	R:R:P147	7.22	No	No	0	4	6
85	R:R:K140	R:R:W146	9.28	No	Yes	0	5	8
86	R:R:L141	R:R:Y352	15.24	No	Yes	0	5	4
87	R:R:A143	R:R:R145	2.77	No	No	0	5	4
88	R:R:D149	R:R:R145	3.57	No	No	0	3	4
89	R:R:P147	R:R:W146	8.11	No	Yes	0	6	8
90	R:R:C158	R:R:W146	10.45	No	Yes	2	9	8
91	R:R:C239	R:R:W146	11.75	No	Yes	2	9	8
92	L:L:I20	R:R:W146	7.05	Yes	Yes	2	0	8
93	R:R:F148	R:R:F153	11.79	No	No	0	7	7
94	R:R:D149	R:R:H150	20.17	No	No	0	3	3
95	R:R:G154	R:R:L157	3.42	No	No	0	8	6
96	R:R:F156	R:R:L160	3.65	No	No	0	2	5
97	R:R:C158	R:R:F224	4.19	No	Yes	2	9	6
98	R:R:C158	R:R:C239	7.28	No	No	2	9	9
99	R:R:I222	R:R:K159	4.36	No	No	0	4	7
100	R:R:F161	R:R:L160	2.44	No	No	0	6	5
101	R:R:E220	R:R:P162	3.14	Yes	No	0	5	6
102	R:R:F224	R:R:P162	11.56	Yes	No	2	6	6
103	L:L:I20	R:R:P162	6.77	Yes	No	2	0	6
104	R:R:F163	R:R:S167	6.61	Yes	No	7	6	6
105	R:R:F163	R:R:F214	3.22	Yes	Yes	7	6	4
106	R:R:A217	R:R:F163	4.16	No	Yes	0	7	6
107	R:R:A221	R:R:F163	5.55	No	Yes	0	5	6
108	R:R:F214	R:R:L164	2.44	Yes	No	0	4	5
109	L:L:W21	R:R:Q165	5.48	No	No	0	0	7
110	R:R:E220	R:R:K166	10.8	Yes	No	0	5	4
111	R:R:K166	R:R:L259	2.82	No	No	0	4	5
112	L:L:W21	R:R:K166	9.28	No	No	0	0	4
113	R:R:F214	R:R:S167	9.25	Yes	No	7	4	6
114	R:R:V169	R:R:Y263	6.31	No	No	0	7	6
115	R:R:I171	R:R:W210	12.92	No	Yes	0	8	9
116	R:R:I171	R:R:S213	9.29	No	No	0	8	8
117	R:R:P267	R:R:V173	3.53	No	No	0	9	8
118	R:R:I209	R:R:L174	2.85	No	No	0	7	6
119	R:R:I209	R:R:N175	7.08	No	No	0	7	8
120	R:R:L179	R:R:R183	6.07	No	No	0	9	9
121	R:R:S180	R:R:T271	6.4	No	No	0	9	8
122	R:R:S180	R:R:Y275	8.9	No	Yes	0	9	9
123	R:R:D182	R:R:V181	2.92	Yes	No	0	8	6
124	R:R:F274	R:R:V181	3.93	No	No	0	7	6
125	R:R:D182	R:R:R185	7.15	Yes	No	0	8	5
126	R:R:R183	R:R:Y275	9.26	No	Yes	0	9	9
127	R:R:A188	R:R:Y184	5.34	No	No	0	7	8
128	R:R:L277	R:R:Y184	3.52	No	No	0	4	8
129	R:R:R185	R:R:S189	2.64	No	No	0	5	6
130	R:R:M278	R:R:V187	7.61	No	No	0	8	8
131	R:R:M282	R:R:V187	3.04	No	No	0	8	8
132	R:R:Q194	R:R:R192	14.02	No	No	0	5	5
133	R:R:I198	R:R:P199	3.39	No	No	0	7	3
134	R:R:P199	R:R:T202	8.74	No	No	0	3	8
135	R:R:I204	R:R:L200	7.14	No	No	0	4	4
136	R:R:E205	R:R:V201	4.28	No	No	0	5	5
137	R:R:I211	R:R:V207	3.07	No	No	0	4	4
138	R:R:F214	R:R:W210	6.01	Yes	Yes	0	4	9
139	R:R:L212	R:R:L216	6.92	No	No	9	4	5
140	R:R:I218	R:R:P219	3.39	No	No	0	5	9
141	R:R:I218	R:R:I222	2.94	No	No	0	5	4
142	R:R:F247	R:R:P219	5.78	No	No	0	4	9
143	R:R:P219	R:R:Y251	9.74	No	No	0	9	3
144	R:R:E220	R:R:Y251	12.35	Yes	No	0	5	3
145	R:R:E220	R:R:K255	8.1	Yes	No	0	5	6
146	R:R:F224	R:R:L241	7.31	Yes	Yes	2	6	5
147	L:L:I20	R:R:F224	2.51	Yes	Yes	2	0	6
148	R:R:N242	R:R:V225	2.96	No	No	0	3	3
149	R:R:C239	R:R:M226	3.24	No	No	0	9	6
150	R:R:P228	R:R:V227	3.53	No	Yes	0	1	1
151	R:R:T238	R:R:V227	3.17	No	Yes	0	3	1
152	R:R:M240	R:R:V227	7.61	No	Yes	0	4	1
153	L:L:L6	R:R:V227	2.98	No	Yes	0	0	1
154	R:R:K237	R:R:P228	5.02	No	No	0	4	1
155	R:R:F229	R:R:H236	9.05	No	No	0	3	2
156	R:R:F229	R:R:T238	6.49	No	No	0	3	3
157	L:L:V12	R:R:F229	3.93	No	No	0	0	3
158	R:R:E230	R:R:G233	4.91	No	No	0	2	4
159	R:R:R232	R:R:Y231	3.09	Yes	Yes	4	2	1
160	L:L:Y13	R:R:Y231	20.85	No	Yes	0	0	1
161	R:R:E234	R:R:R232	10.47	No	Yes	0	2	2
162	R:R:E234	R:R:H236	8.62	No	No	0	2	2
163	L:L:H16	R:R:T238	8.21	No	No	0	0	3
164	L:L:C15	R:R:M240	3.24	No	No	0	0	4
165	R:R:L241	R:R:Q252	5.32	Yes	Yes	2	5	4
166	L:L:S2	R:R:L241	6.01	No	Yes	2	0	5
167	R:R:A243	R:R:Q252	3.03	No	Yes	0	5	4
168	R:R:M248	R:R:S245	4.6	No	No	0	5	2
169	R:R:F247	R:R:M248	4.98	No	No	0	4	5
170	R:R:F250	R:R:V254	6.55	No	No	0	1	4
171	L:L:S2	R:R:Q252	8.66	No	Yes	2	0	4
172	R:R:D253	R:R:V254	4.38	No	No	0	3	4
173	R:R:D256	R:R:K255	2.77	No	No	0	5	6
174	R:R:K255	R:R:L259	4.23	No	No	0	6	5
175	R:R:D256	R:R:R326	3.57	No	Yes	0	5	5
176	R:R:D256	R:R:K330	5.53	No	No	0	5	5
177	R:R:I327	R:R:W257	5.87	No	No	0	5	4
178	R:R:F262	R:R:W258	3.01	No	No	0	4	4
179	R:R:L259	R:R:Y263	3.52	No	No	0	5	6
180	R:R:F260	R:R:G261	6.02	Yes	No	10	6	4
181	R:R:C265	R:R:F260	4.19	No	Yes	10	4	6
182	R:R:F260	R:R:H323	6.79	Yes	No	0	6	7
183	R:R:C265	R:R:G261	3.92	No	No	10	4	4
184	R:R:F262	R:R:Y263	8.25	No	No	0	4	6
185	R:R:F262	R:R:M266	3.73	No	No	0	4	5
186	R:R:F264	R:R:F315	3.22	No	Yes	0	8	9
187	R:R:F264	R:R:F320	3.22	No	No	0	8	6
188	R:R:M266	R:R:P267	11.74	No	No	0	5	9
189	R:R:L268	R:R:V312	2.98	No	No	0	7	8
190	R:R:F315	R:R:L268	2.44	Yes	No	0	9	7
191	R:R:A316	R:R:L268	3.15	No	No	0	6	7
192	R:R:T271	R:R:V312	3.17	No	No	0	8	8
193	R:R:M278	R:R:Y275	4.79	No	Yes	8	8	9
194	R:R:V308	R:R:Y275	8.83	No	Yes	8	8	9
195	R:R:M278	R:R:V308	3.04	No	No	8	8	8
196	R:R:L283	R:R:T279	4.42	No	No	0	5	6
197	R:R:F309	R:R:T279	6.49	No	No	0	5	6
198	R:R:M282	R:R:R301	4.96	No	Yes	0	8	7
199	R:R:M282	R:R:V304	7.61	No	No	0	8	7
200	R:R:A305	R:R:L283	3.15	No	No	0	7	5
201	R:R:L294	R:R:L298	5.54	No	No	0	4	4
202	R:R:E296	R:R:H297	11.08	No	No	0	1	4
203	R:R:H297	R:R:R301	3.39	No	Yes	0	4	7
204	R:R:K299	R:R:R302	4.95	No	No	12	5	5
205	R:R:E303	R:R:K299	4.05	No	No	12	8	5
206	R:R:E303	R:R:R302	3.49	No	No	12	8	5
207	R:R:T307	R:R:V372	4.76	No	No	0	8	7
208	R:R:C310	R:R:I314	3.27	No	No	0	6	6
209	R:R:I314	R:R:I364	5.89	No	No	0	6	6
210	R:R:F315	R:R:W319	8.02	Yes	No	11	9	8
211	R:R:F315	R:R:N361	8.46	Yes	No	11	9	9
212	R:R:C318	R:R:M360	4.86	No	No	0	9	5
213	R:R:A358	R:R:W319	2.59	No	No	0	7	8
214	R:R:N361	R:R:W319	10.17	No	No	11	9	8
215	R:R:F320	R:R:P321	2.89	No	No	0	6	9
216	R:R:F320	R:R:L324	4.87	No	No	0	6	6
217	R:R:M350	R:R:P321	3.35	No	No	0	5	9
218	R:R:L357	R:R:P321	3.28	No	No	0	7	9
219	R:R:D351	R:R:L322	2.71	Yes	No	0	4	6
220	R:R:G354	R:R:L322	6.84	No	No	0	7	6
221	R:R:I355	R:R:L322	2.85	No	No	0	6	6
222	R:R:I327	R:R:L324	2.85	No	No	0	5	6
223	R:R:L324	R:R:L328	4.15	No	No	0	6	5
224	R:R:L347	R:R:S325	3	Yes	No	0	4	5
225	R:R:D351	R:R:S325	8.83	Yes	No	0	4	5
226	R:R:D351	R:R:R326	11.91	Yes	Yes	1	4	5
227	L:L:D18	R:R:R326	10.72	Yes	Yes	1	0	5
228	L:L:I19	R:R:R326	2.51	No	Yes	1	0	5
229	L:L:W21	R:R:R326	5	No	Yes	0	0	5
230	R:R:L328	R:R:V332	2.98	No	No	0	5	4
231	R:R:K329	R:R:Y333	3.58	No	Yes	0	4	3
232	R:R:K329	R:R:L347	2.82	No	Yes	0	4	4
233	L:L:F14	R:R:K329	6.2	Yes	No	0	0	4
234	R:R:T331	R:R:V332	4.76	No	No	0	4	4
235	R:R:E335	R:R:Y333	3.37	No	Yes	3	1	3
236	R:R:R340	R:R:Y333	14.4	Yes	Yes	3	5	3
237	R:R:L344	R:R:Y333	4.69	No	Yes	0	3	3
238	L:L:D8	R:R:Y333	5.75	Yes	Yes	3	0	3
239	R:R:M336	R:R:N334	5.61	No	No	0	1	1
240	R:R:D337	R:R:N334	4.04	No	No	0	1	1
241	L:L:S5	R:R:E335	2.87	No	No	3	0	1
242	L:L:D8	R:R:E335	7.8	Yes	No	3	0	1
243	R:R:D337	R:R:R340	4.76	No	Yes	0	1	5
244	L:L:D8	R:R:R340	10.72	Yes	Yes	3	0	5
245	L:L:E10	R:R:R340	5.82	No	Yes	3	0	5
246	R:R:L343	R:R:L347	2.77	No	Yes	0	2	4
247	R:R:L348	R:R:Y352	4.69	No	Yes	0	4	4
248	L:L:F14	R:R:L348	7.31	Yes	No	0	0	4
249	L:L:D18	R:R:D351	3.99	Yes	Yes	1	0	4
250	L:L:I19	R:R:Y352	4.84	No	Yes	1	0	4
251	R:R:N365	R:R:P366	6.52	No	No	0	9	9
252	R:R:F376	R:R:L369	3.65	Yes	No	0	9	9
253	R:R:F371	R:R:Y370	7.22	No	Yes	0	6	7
254	R:R:K377	R:R:Y370	16.72	No	Yes	13	8	7
255	R:R:F380	R:R:Y370	10.32	No	Yes	0	7	7
256	R:R:Q381	R:R:Y370	3.38	No	Yes	13	4	7
257	R:R:F376	R:R:F380	8.57	Yes	No	0	9	7
258	R:R:K377	R:R:Q381	2.71	No	No	13	8	4
259	R:R:N378	R:R:S382	4.47	No	No	0	5	4
260	L:L:C1	L:L:F14	2.79	No	Yes	1	0	0
261	L:L:C1	L:L:C15	7.28	No	No	0	0	0
262	L:L:C1	L:L:D18	4.67	No	Yes	1	0	0
263	L:L:C11	L:L:C3	7.28	No	No	0	0	0
264	L:L:M7	L:L:S5	7.67	No	No	0	0	0
265	L:L:D8	L:L:S5	2.94	Yes	No	3	0	0
266	L:L:D8	L:L:E10	2.6	Yes	No	3	0	0
267	L:L:C11	L:L:D8	4.67	No	Yes	0	0	0
268	L:L:D18	L:L:F14	10.75	Yes	Yes	1	0	0
269	L:L:D18	L:L:I19	7	Yes	No	1	0	0
270	R:R:F148	R:R:N151	2.42	No	No	0	7	7
271	L:L:K9	R:R:Y231	2.39	No	Yes	0	0	1
272	L:L:L17	L:L:Y13	2.34	No	No	0	0	0
273	R:R:C363	R:R:G94	1.96	No	No	0	8	8
274	R:R:A143	R:R:G144	1.95	No	No	0	5	4
275	R:R:C177	R:R:P267	1.88	No	No	0	7	9
276	R:R:G170	R:R:S213	1.86	No	No	0	6	8
277	R:R:C177	R:R:C270	1.82	No	No	0	7	7
278	R:R:G354	R:R:I353	1.76	No	No	0	7	5
279	R:R:G223	R:R:L241	1.71	No	Yes	0	5	5
280	R:R:A188	R:R:V187	1.7	No	No	0	7	8
281	R:R:C88	R:R:T84	1.69	No	No	0	5	5
282	R:R:A117	R:R:T202	1.68	No	No	0	5	8
283	R:R:L134	R:R:P135	1.64	No	No	0	7	8
284	R:R:L157	R:R:P147	1.64	No	No	0	6	6
285	R:R:G195	R:R:Q194	1.64	No	No	0	4	5
286	R:R:E234	R:R:G233	1.64	No	No	0	2	4
287	R:R:C318	R:R:I314	1.64	No	No	0	9	6
288	R:R:S189	R:R:S191	1.63	No	No	0	6	6
289	R:R:A117	R:R:I206	1.62	No	No	0	5	8
290	R:R:A178	R:R:I209	1.62	No	No	0	7	7
291	R:R:A203	R:R:I198	1.62	No	No	0	3	7
292	R:R:S373	R:R:V372	1.62	No	No	0	9	7
293	R:R:A305	R:R:K306	1.61	No	No	0	7	6
294	R:R:V225	R:R:V227	1.6	No	Yes	0	3	1
295	R:R:T89	R:R:V85	1.59	No	No	0	4	6
296	R:R:T100	R:R:V96	1.59	No	No	0	6	4
297	R:R:P70	R:R:Q71	1.58	No	No	0	2	2
298	R:R:A123	R:R:L101	1.58	No	Yes	0	9	9
299	R:R:A120	R:R:L102	1.58	No	No	0	6	7
300	R:R:C379	R:R:N378	1.57	No	No	0	6	5
301	R:R:I86	R:R:V85	1.54	No	No	0	5	6
302	R:R:I273	R:R:V269	1.54	No	No	0	3	3
303	R:R:K159	R:R:V155	1.52	No	No	0	7	2
304	R:R:F148	R:R:G154	1.51	No	No	0	7	8
305	R:R:A188	R:R:E281	1.51	No	No	0	7	4
306	R:R:A243	R:R:E249	1.51	No	No	0	5	1
307	R:R:L142	R:R:V138	1.49	No	No	0	5	7
308	R:R:L317	R:R:V313	1.49	No	No	0	6	5
309	R:R:I82	R:R:I86	1.47	No	No	0	6	5
310	R:R:I215	R:R:I218	1.47	No	No	0	5	5
311	L:L:S4	R:R:Q252	1.44	No	Yes	0	0	4
312	R:R:K374	R:R:K377	1.44	No	No	0	6	8
313	R:R:I215	R:R:L212	1.43	No	No	9	5	4
314	R:R:I215	R:R:L216	1.43	No	No	9	5	5
315	R:R:I364	R:R:L311	1.43	No	No	0	6	8
316	R:R:I82	R:R:N83	1.42	No	Yes	0	6	5
317	R:R:I86	R:R:N356	1.42	No	No	0	5	5
318	R:R:K338	R:R:N339	1.4	No	No	0	2	2
319	R:R:K299	R:R:Q300	1.36	No	No	0	5	7
320	R:R:E249	R:R:K246	1.35	No	No	0	1	3
321	R:R:D337	R:R:N339	1.35	No	No	0	1	2
322	R:R:F376	R:R:S373	1.32	Yes	No	0	9	9
323	R:R:F79	R:R:T76	1.3	Yes	No	0	3	3
324	R:R:D182	R:R:E205	1.3	Yes	No	0	8	5
325	R:R:F309	R:R:T276	1.3	No	No	0	5	3
326	R:R:K306	R:R:R302	1.24	No	No	0	6	5
327	R:R:F346	R:R:L347	1.22	No	Yes	0	3	4
328	R:R:L283	R:R:R301	1.21	No	Yes	0	5	7
329	R:R:L294	R:R:R301	1.21	No	Yes	0	4	7
330	R:R:F260	R:R:F264	1.07	Yes	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I75	3.8575	4	1	2
2	R:R:F79	9	5	1	3
3	R:R:N83	7.5	4	1	5
4	R:R:L101	2.7875	4	0	9
5	R:R:L122	3.332	5	5	9
6	R:R:D126	6.3725	4	5	9
7	R:R:Y129	8.564	5	6	7
8	R:R:W146	8.36	6	2	8
9	R:R:F163	4.885	4	7	6
10	R:R:D182	4.2	4	0	8
11	R:R:W210	7.0825	4	0	9
12	R:R:F214	5.23	4	7	4
13	R:R:E220	8.5975	4	0	5
14	R:R:F224	6.3925	4	2	6
15	R:R:V227	3.778	5	0	1
16	R:R:Y231	8.32	4	4	1
17	R:R:R232	5.5875	4	4	2
18	R:R:L241	5.0875	4	2	5
19	R:R:Q252	4.6125	4	2	4
20	R:R:F260	4.5175	4	10	6
21	R:R:Y275	7.945	4	8	9
22	R:R:R301	2.6925	4	0	7
23	R:R:F315	5.535	4	11	9
24	R:R:R326	6.742	5	1	5
25	R:R:Y333	6.358	5	3	3
26	R:R:R340	8.925	4	3	5
27	R:R:L347	2.4525	4	0	4
28	R:R:D351	6.86	4	1	4
29	R:R:Y352	7.096	5	1	4
30	R:R:Y370	9.41	4	13	7
31	R:R:F376	3.995	4	0	9
32	L:L:D8	5.74667	6	3	0
33	L:L:F14	6.7625	4	1	0
34	L:L:D18	7.426	5	1	0
35	L:L:I20	4.79	4	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E10	R:R:C69	20.6689	4.56	No	No	0	0	4
2	L:L:E10	R:R:R340	12.0353	5.82	No	Yes	3	0	5
3	R:R:R340	R:R:Y333	22.0428	14.4	Yes	Yes	3	5	3
4	R:R:K329	R:R:Y333	50.406	3.58	No	Yes	0	4	3
5	L:L:F14	R:R:K329	44.7	6.2	Yes	No	0	0	4
6	L:L:C1	L:L:C15	40.4995	7.28	No	No	0	0	0
7	L:L:C15	R:R:M240	39.0686	3.24	No	No	0	0	4
8	R:R:M240	R:R:V227	37.686	7.61	No	Yes	0	4	1
9	R:R:T238	R:R:V227	28.7056	3.17	No	Yes	0	3	1
10	R:R:F229	R:R:T238	25.6419	6.49	No	No	0	3	3
11	R:R:F229	R:R:H236	22.5431	9.05	No	No	0	3	2
12	R:R:E234	R:R:H236	20.9806	8.62	No	No	0	2	2
13	R:R:E234	R:R:R232	16.2402	10.47	No	Yes	0	2	2
14	L:L:D8	L:L:E10	12.0397	2.6	Yes	No	3	0	0
15	L:L:D8	R:R:Y333	20.2958	5.75	Yes	Yes	3	0	3
16	R:R:C341	R:R:C69	10.3718	7.28	No	No	0	8	4
17	L:L:F14	R:R:L348	11.7544	7.31	Yes	No	0	0	4
18	L:L:I19	R:R:Y352	44.4279	4.84	No	Yes	1	0	4
19	L:L:C1	L:L:D18	34.2668	4.67	No	Yes	1	0	0
20	R:R:N83	R:R:Y352	37.6553	3.49	Yes	Yes	1	5	4
21	R:R:N356	R:R:N83	28.6881	8.17	No	Yes	0	5	5
22	R:R:L134	R:R:S87	19.396	3	No	No	0	7	6
23	R:R:N356	R:R:S87	21.2878	4.47	No	No	0	5	6
24	R:R:I90	R:R:T359	13.6681	9.12	No	No	0	7	7
25	R:R:L134	R:R:T359	15.5862	4.42	No	No	0	7	7
26	R:R:I90	R:R:M360	11.7412	2.92	No	No	0	7	5
27	R:R:D126	R:R:N98	45.174	5.39	Yes	No	0	9	9
28	R:R:D126	R:R:L122	48.1455	4.07	Yes	Yes	5	9	9
29	R:R:L122	R:R:N175	53.3907	4.12	Yes	No	0	9	8
30	R:R:N175	R:R:S121	57.2883	8.94	No	No	0	8	9
31	R:R:S121	R:R:W210	65.5445	3.71	No	Yes	0	9	9
32	R:R:F214	R:R:W210	70.6536	6.01	Yes	Yes	0	4	9
33	R:R:F214	R:R:L164	74.6697	2.44	Yes	No	0	4	5
34	R:R:I132	R:R:L164	75.4466	5.71	No	No	0	6	5
35	R:R:D133	R:R:I132	76.2147	2.8	No	No	0	7	6
36	R:R:D133	R:R:Q165	53.6277	18.27	No	No	6	7	7
37	L:L:W21	R:R:Q165	100	5.48	No	No	0	0	7
38	L:L:W21	R:R:R326	84.6377	5	No	Yes	0	0	5
39	L:L:D18	R:R:R326	57.4946	10.72	Yes	Yes	1	0	5
40	R:R:F376	R:R:F380	12.1143	8.57	Yes	No	0	9	7
41	R:R:F376	R:R:L101	18.4348	2.44	Yes	Yes	0	9	9
42	R:R:A123	R:R:L101	38.6253	1.58	No	Yes	0	9	9
43	R:R:A123	R:R:N98	39.7533	3.13	No	No	0	9	9
44	R:R:I105	R:R:L101	19.7603	2.85	No	Yes	0	7	9
45	R:R:M111	R:R:N116	10.758	9.82	No	No	0	7	8
46	R:R:I105	R:R:N116	15.9549	4.25	No	No	0	7	8
47	R:R:I206	R:R:S121	10.8107	3.1	No	No	0	8	9
48	R:R:L118	R:R:L179	11.9124	5.54	No	No	0	8	9
49	R:R:L179	R:R:R183	13.2028	6.07	No	No	0	9	9
50	R:R:R183	R:R:Y275	14.4757	9.26	No	Yes	0	9	9
51	R:R:S180	R:R:Y275	43.4271	8.9	No	Yes	0	9	9
52	R:R:S180	R:R:T271	44.4761	6.4	No	No	0	9	8
53	R:R:T271	R:R:V312	45.5164	3.17	No	No	0	8	8
54	R:R:L268	R:R:V312	46.5479	2.98	No	No	0	7	8
55	R:R:F315	R:R:L268	48.5845	2.44	Yes	No	0	9	7
56	R:R:F315	R:R:W319	63.363	8.02	Yes	No	11	9	8
57	R:R:A358	R:R:W319	65.3338	2.59	No	No	0	7	8
58	R:R:A358	R:R:Y129	66.1809	4	No	Yes	0	7	7
59	R:R:Q165	R:R:Y129	46.2582	3.38	No	Yes	6	7	7
60	R:R:D182	R:R:L118	10.6615	5.43	Yes	No	0	8	8
61	R:R:I136	R:R:N137	19.9754	2.83	No	No	0	7	6
62	R:R:I355	R:R:N137	34.8857	5.66	No	No	0	6	6
63	R:R:I355	R:R:L322	35.904	2.85	No	No	0	6	6
64	R:R:D351	R:R:L322	39.5119	2.71	Yes	No	0	4	6
65	L:L:D18	R:R:D351	20.4407	3.99	Yes	Yes	1	0	4
66	R:R:I136	R:R:W146	15.2087	3.52	No	Yes	0	7	8
67	L:L:I20	R:R:W146	31.4357	7.05	Yes	Yes	2	0	8
68	L:L:I20	R:R:N137	21.0859	2.83	Yes	No	0	0	6
69	R:R:A143	R:R:F139	12.7244	4.16	No	No	0	5	4
70	R:R:F139	R:R:P147	15.2438	7.22	No	No	0	4	6
71	R:R:P147	R:R:W146	30.176	8.11	No	Yes	0	6	8
72	R:R:F224	R:R:P162	17.9564	11.56	Yes	No	2	6	6
73	R:R:E220	R:R:P162	43.73	3.14	Yes	No	0	5	6
74	R:R:E220	R:R:K166	46.8332	10.8	Yes	No	0	5	4
75	L:L:W21	R:R:K166	50.1251	9.28	No	No	0	0	4
76	R:R:E220	R:R:K255	16.0075	8.1	Yes	No	0	5	6
77	R:R:D256	R:R:K255	18.1232	2.77	No	No	0	5	6
78	R:R:D256	R:R:R326	19.7208	3.57	No	Yes	0	5	5
79	R:R:G154	R:R:L157	10.1962	3.42	No	No	0	8	6
80	R:R:L157	R:R:P147	12.7244	1.64	No	No	0	6	6
81	R:R:I218	R:R:P219	12.7771	3.39	No	No	0	5	9
82	R:R:P219	R:R:Y251	19.8876	9.74	No	No	0	9	3
83	R:R:E220	R:R:Y251	21.6433	12.35	Yes	No	0	5	3
84	R:R:L259	R:R:Y263	12.8956	3.52	No	No	0	5	6
85	R:R:F262	R:R:M266	10.0909	3.73	No	No	0	4	5
86	R:R:F262	R:R:Y263	14.0675	8.25	No	No	0	4	6
87	R:R:M278	R:R:V187	27.8848	7.61	No	No	0	8	8
88	R:R:M278	R:R:Y275	28.969	4.79	No	Yes	8	8	9
89	R:R:M282	R:R:V187	21.8935	3.04	No	No	0	8	8
90	R:R:F224	R:R:L241	17.9388	7.31	Yes	Yes	2	6	5
91	R:R:L241	R:R:Q252	11.2145	5.32	Yes	Yes	2	5	4
92	R:R:F264	R:R:F320	13.2511	3.22	No	No	0	8	6
93	R:R:F264	R:R:F315	19.5497	3.22	No	Yes	0	8	9
94	R:R:L283	R:R:R301	13.2423	1.21	No	Yes	0	5	7
95	R:R:M282	R:R:R301	19.4926	4.96	No	Yes	0	8	7
96	R:R:D351	R:R:S325	12.1757	8.83	Yes	No	0	4	5
97	L:L:D18	L:L:F14	40.8814	10.75	Yes	Yes	1	0	0
98	R:R:L347	R:R:S325	10.8985	3	Yes	No	0	4	5
99	L:L:I19	R:R:R326	37.7957	2.51	No	Yes	1	0	5
100	R:R:D351	R:R:R326	15.5642	11.91	Yes	Yes	1	4	5
101	L:L:I20	R:R:P162	24.3295	6.77	Yes	No	2	0	6
102	R:R:D133	R:R:Y129	23.342	25.29	No	Yes	6	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y231	R:R:Y68	6.95	4	Yes	No	1	4	1	2
R:R:R232	R:R:Y68	4.12	4	Yes	No	2	4	2	2
R:R:C69	R:R:P70	3.77	0	No	No	4	2	1	2
R:R:C341	R:R:C69	7.28	0	No	No	8	4	2	1
L:L:E10	R:R:C69	4.56	3	No	No	0	4	0	1
R:R:K74	R:R:Q72	6.78	0	No	No	3	2	2	1
R:R:Q72	R:R:R232	4.67	0	No	Yes	2	2	1	2
L:L:Y13	R:R:Q72	5.64	0	No	No	0	2	0	1
R:R:F79	R:R:I75	2.51	1	Yes	Yes	3	2	2	2
R:R:I75	R:R:L348	5.71	1	Yes	No	2	4	2	1
R:R:F79	R:R:N83	16.92	1	Yes	Yes	3	5	2	2
R:R:F79	R:R:Y352	7.22	1	Yes	Yes	3	4	2	1
R:R:N83	R:R:Y352	3.49	1	Yes	Yes	5	4	2	1
R:R:D133	R:R:Y129	25.29	6	No	Yes	7	7	2	2
R:R:Q165	R:R:Y129	3.38	6	No	Yes	7	7	1	2
R:R:D133	R:R:Q165	18.27	6	No	No	7	7	2	1
R:R:I136	R:R:N137	2.83	0	No	No	7	6	2	1
R:R:I136	R:R:W146	3.52	0	No	Yes	7	8	2	1
R:R:I355	R:R:N137	5.66	0	No	No	6	6	2	1
L:L:I20	R:R:N137	2.83	2	Yes	No	0	6	0	1
R:R:K140	R:R:W146	9.28	0	No	Yes	5	8	2	1
R:R:L141	R:R:Y352	15.24	0	No	Yes	5	4	2	1
R:R:P147	R:R:W146	8.11	0	No	Yes	6	8	2	1
R:R:C158	R:R:W146	10.45	2	No	Yes	9	8	2	1
R:R:C239	R:R:W146	11.75	2	No	Yes	9	8	2	1
L:L:I20	R:R:W146	7.05	2	Yes	Yes	0	8	0	1
R:R:C158	R:R:F224	4.19	2	No	Yes	9	6	2	1
R:R:C158	R:R:C239	7.28	2	No	No	9	9	2	2
R:R:E220	R:R:P162	3.14	0	Yes	No	5	6	2	1
R:R:F224	R:R:P162	11.56	2	Yes	No	6	6	1	1
L:L:I20	R:R:P162	6.77	2	Yes	No	0	6	0	1
L:L:W21	R:R:Q165	5.48	0	No	No	0	7	0	1
R:R:E220	R:R:K166	10.8	0	Yes	No	5	4	2	1
R:R:K166	R:R:L259	2.82	0	No	No	4	5	1	2
L:L:W21	R:R:K166	9.28	0	No	No	0	4	0	1
R:R:F224	R:R:L241	7.31	2	Yes	Yes	6	5	1	1
L:L:I20	R:R:F224	2.51	2	Yes	Yes	0	6	0	1
R:R:P228	R:R:V227	3.53	0	No	Yes	1	1	2	1
R:R:T238	R:R:V227	3.17	0	No	Yes	3	1	1	1
R:R:M240	R:R:V227	7.61	0	No	Yes	4	1	1	1
L:L:L6	R:R:V227	2.98	0	No	Yes	0	1	0	1
R:R:F229	R:R:H236	9.05	0	No	No	3	2	1	2
R:R:F229	R:R:T238	6.49	0	No	No	3	3	1	1
L:L:V12	R:R:F229	3.93	0	No	No	0	3	0	1
R:R:R232	R:R:Y231	3.09	4	Yes	Yes	2	1	2	1
L:L:Y13	R:R:Y231	20.85	0	No	Yes	0	1	0	1
L:L:H16	R:R:T238	8.21	0	No	No	0	3	0	1
L:L:C15	R:R:M240	3.24	0	No	No	0	4	0	1
R:R:L241	R:R:Q252	5.32	2	Yes	Yes	5	4	1	1
L:L:S2	R:R:L241	6.01	2	No	Yes	0	5	0	1
R:R:A243	R:R:Q252	3.03	0	No	Yes	5	4	2	1
L:L:S2	R:R:Q252	8.66	2	No	Yes	0	4	0	1
R:R:D256	R:R:R326	3.57	0	No	Yes	5	5	2	1
R:R:D351	R:R:L322	2.71	1	Yes	No	4	6	1	2
R:R:I355	R:R:L322	2.85	0	No	No	6	6	2	2
R:R:L347	R:R:S325	3	0	Yes	No	4	5	2	2
R:R:D351	R:R:S325	8.83	1	Yes	No	4	5	1	2
R:R:D351	R:R:R326	11.91	1	Yes	Yes	4	5	1	1
L:L:D18	R:R:R326	10.72	1	Yes	Yes	0	5	0	1
L:L:I19	R:R:R326	2.51	1	No	Yes	0	5	0	1
L:L:W21	R:R:R326	5	0	No	Yes	0	5	0	1
R:R:K329	R:R:Y333	3.58	0	No	Yes	4	3	1	1
R:R:K329	R:R:L347	2.82	0	No	Yes	4	4	1	2
L:L:F14	R:R:K329	6.2	1	Yes	No	0	4	0	1
R:R:E335	R:R:Y333	3.37	3	No	Yes	1	3	1	1
R:R:R340	R:R:Y333	14.4	3	Yes	Yes	5	3	1	1
R:R:L344	R:R:Y333	4.69	0	No	Yes	3	3	2	1
L:L:D8	R:R:Y333	5.75	3	Yes	Yes	0	3	0	1
L:L:S5	R:R:E335	2.87	3	No	No	0	1	0	1
L:L:D8	R:R:E335	7.8	3	Yes	No	0	1	0	1
R:R:D337	R:R:R340	4.76	0	No	Yes	1	5	2	1
L:L:D8	R:R:R340	10.72	3	Yes	Yes	0	5	0	1
L:L:E10	R:R:R340	5.82	3	No	Yes	0	5	0	1
R:R:L348	R:R:Y352	4.69	0	No	Yes	4	4	1	1
L:L:F14	R:R:L348	7.31	1	Yes	No	0	4	0	1
L:L:D18	R:R:D351	3.99	1	Yes	Yes	0	4	0	1
L:L:I19	R:R:Y352	4.84	1	No	Yes	0	4	0	1
L:L:K9	R:R:Y231	2.39	0	No	Yes	0	1	0	1
R:R:G223	R:R:L241	1.71	0	No	Yes	5	5	2	1
R:R:V225	R:R:V227	1.6	0	No	Yes	3	1	2	1
L:L:S4	R:R:Q252	1.44	0	No	Yes	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XVI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	308
Number of Links	330
Number of Hubs	35
Number of Links mediated by Hubs	132
Number of Communities	13
Number of Nodes involved in Communities	56
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	103
Number Of Links MetaPath	102
Number of Shortest Paths	56965
Length Of Smallest Path	3
Average Path Length	16.3622
Length of Longest Path	40
Minimum Path Strength	1.21
Average Path Strength	5.56341
Maximum Path Strength	16.985
Minimum Path Correlation	0.7
Average Path Correlation	0.939916
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	50.9666
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.3819
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• bombesin receptor binding • protein binding • binding • signaling receptor binding • endothelin A receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • molecular function activator activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • endothelin B receptor binding • developmental process • multicellular organism development • multicellular organismal process • skeletal system development • connective tissue development • anatomical structure development • animal organ development • tissue development • cartilage development • system development • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • regulation of biological process • regulation of cellular process
Gene Ontology	Biological Process	• developmental process • multicellular organism development • multicellular organismal process • skeletal system development • connective tissue development • anatomical structure development • animal organ development • tissue development • cartilage development • system development • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • regulation of biological process • regulation of cellular process • biological regulation • positive regulation of biological process • reactive nitrogen species metabolic process • nitric oxide metabolic process • positive regulation of metabolic process • nitric oxide biosynthetic process • biosynthetic process • positive regulation of biosynthetic process • cellular process • metabolic process • regulation of nitric oxide metabolic process • positive regulation of nitric oxide biosynthetic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to human chorionic gonadotropin • cellular response to human chorionic gonadotropin stimulus • response to stimulus • cellular response to gonadotropin stimulus • response to endogenous stimulus • response to gonadotropin • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • heart process • system process • regulation of heart contraction • regulation of system process • positive regulation of heart rate • positive regulation of blood circulation • positive regulation of heart contraction • circulatory system process • regulation of blood circulation • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • positive regulation of cell communication • positive regulation of signal transduction • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • positive regulation of signaling • regulation of animal organ morphogenesis • regulation of developmental process • regulation of odontogenesis • odontogenesis • positive regulation of odontogenesis • positive regulation of developmental process • anatomical structure morphogenesis • positive regulation of animal organ morphogenesis • animal organ morphogenesis • regulation of anatomical structure morphogenesis • cell surface receptor signaling pathway • canonical Wnt signaling pathway • Wnt signaling pathway • response to ketone • response to lipid • response to oxygen-containing compound • response to testosterone • dorsal/ventral pattern formation • pattern specification process • regionalization • respiratory gaseous exchange by respiratory system • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • stem cell fate commitment • cellular developmental process • chordate embryonic development • mesenchyme development • embryo development • neural crest formation • embryo development ending in birth or egg hatching • cell differentiation • neural crest cell fate commitment • neural crest cell differentiation • epithelial to mesenchymal transition • stem cell differentiation • anatomical structure formation involved in morphogenesis • mesenchymal cell differentiation • cell fate commitment • positive regulation of organelle organization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of mitotic nuclear division • positive regulation of mitotic nuclear division • mitotic cell cycle • cellular component organization • regulation of mitotic cell cycle • positive regulation of cell cycle process • cellular component organization or biogenesis • cell cycle • regulation of cell cycle • cell cycle process • mitotic nuclear division • regulation of cell cycle process • organelle fission • positive regulation of nuclear division • regulation of organelle organization • positive regulation of cell cycle • organelle organization • nuclear division • mitotic cell cycle process • regulation of nuclear division • cellular response to metal ion • response to metal ion • cellular response to calcium ion • response to calcium ion • transport • monoatomic ion transmembrane transport • establishment of localization • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • transmembrane transport • localization • monoatomic ion transport • monoatomic cation transport • calcium ion transmembrane transport • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of biological process • negative regulation of cell communication • negative regulation of cellular process • negative regulation of phospholipase C/protein kinase C signal transduction • negative regulation of response to stimulus • negative regulation of signal transduction • phospholipase C/protein kinase C signal transduction • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • morphogenesis of a branching epithelium • response to glucocorticoid • response to corticosteroid • response to steroid hormone • response to dexamethasone • response to salt • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • signal transduction involved in regulation of gene expression • regulation of macromolecule biosynthetic process • macromolecule metabolic process • cellular response to follicle-stimulating hormone stimulus • response to follicle-stimulating hormone • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to toxic substance • response to toxic substance • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • cell population proliferation • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • rhythmic synaptic transmission • trans-synaptic signaling • modulation of chemical synaptic transmission • cell-cell signaling • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • rhythmic excitation • axon extension • axonogenesis • developmental growth • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell growth • cell morphogenesis • neurogenesis • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • neuron projection extension • plasma membrane bounded cell projection organization • developmental cell growth • growth • nervous system development • axon development • cell morphogenesis involved in neuron differentiation • developmental growth involved in morphogenesis • generation of neurons • neuron development • cellular response to xenobiotic stimulus • response to xenobiotic stimulus • RNA metabolic process • regulation of primary metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • transcription by RNA polymerase II • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • negative regulation of macromolecule metabolic process • regulation of transcription by RNA polymerase II • negative regulation of DNA-templated transcription • negative regulation of transcription by RNA polymerase II • negative regulation of metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • response to prostaglandin • response to prostaglandin F • artery development • pharyngeal arch artery morphogenesis • pharyngeal system development • artery morphogenesis • response to peptide • cellular response to interleukin-1 • response to cytokine • cellular response to cytokine stimulus • response to interleukin-1 • noradrenergic neuron differentiation • ear morphogenesis • embryonic organ morphogenesis • middle ear morphogenesis • ear development • sensory organ development • embryonic morphogenesis • sensory organ morphogenesis • embryonic organ development • cellular response to nitrogen compound • cellular response to luteinizing hormone stimulus • response to luteinizing hormone • response to peptide hormone • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • superoxide metabolic process • superoxide anion generation • reactive oxygen species metabolic process • multi-multicellular organism process • maternal process involved in parturition • reproductive process • multicellular organismal reproductive process • parturition • multi-organism reproductive process • positive regulation of canonical NF-kappaB signal transduction • canonical NF-kappaB signal transduction • regulation of canonical NF-kappaB signal transduction • thyroid gland development • endocrine system development • gland development • regulation of systemic arterial blood pressure by endothelin • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • MAPK cascade • ERK1 and ERK2 cascade • vascular associated smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • smooth muscle contraction • vein smooth muscle contraction • response to activity • response to oxidative stress • response to ozone • response to stress • response to reactive oxygen species • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • nitrogen compound transport • secretion • regulation of hormone levels • export from cell • hormone secretion • peptide transport • peptide secretion • secretion by cell • amide transport • peptide hormone secretion • signal release • hormone transport • regulation of chemokine-mediated signaling pathway • response to chemokine • positive regulation of response to cytokine stimulus • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • positive regulation of chemokine-mediated signaling pathway • regulation of G protein-coupled receptor signaling pathway • regulation of cytokine-mediated signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • regulation of response to cytokine stimulus • positive regulation of cytokine-mediated signaling pathway • regulation of localization • regulation of hormone secretion • negative regulation of transport • negative regulation of secretion • regulation of secretion by cell • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of transport • regulation of secretion • glomerular filtration • renal filtration • histamine transport • histamine secretion • cellular response to tumor necrosis factor • response to tumor necrosis factor • biological process involved in interspecies interaction between organisms • immune response • response to other organism • defense response • response to type II interferon • defense response to symbiont • response to external stimulus • cellular response to type II interferon • response to biotic stimulus • immune system process • defense response to other organism • innate immune response • response to external biotic stimulus • nitric oxide transport • renal sodium excretion • inorganic ion homeostasis • regulation of renal system process • homeostatic process • positive regulation of secretion • monoatomic ion homeostasis • monoatomic cation homeostasis • positive regulation of renal sodium excretion • excretion • sodium ion homeostasis • renal tubular secretion • regulation of renal sodium excretion • positive regulation of transport • chemical homeostasis • regulation of excretion • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • artery smooth muscle contraction • tonic smooth muscle contraction • regulation of non-canonical NF-kappaB signal transduction • non-canonical NF-kappaB signal transduction • positive regulation of non-canonical NF-kappaB signal transduction • response to amine • response to amphetamine • regulation of prostaglandin secretion • monocarboxylic acid transport • fatty acid transport • prostaglandin secretion • positive regulation of icosanoid secretion • carboxylic acid transport • lipid transport • regulation of fatty acid transport • organic acid transport • positive regulation of lipid transport • lipid export from cell • prostaglandin transport • regulation of lipid transport • positive regulation of secretion by cell • icosanoid transport • regulation of icosanoid secretion • positive regulation of prostaglandin secretion • icosanoid secretion • organic anion transport • lipid localization • positive regulation of lipid localization • positive regulation of organic acid transport • regulation of lipid localization • macromolecule localization • regulation of organic acid transport • positive regulation of fatty acid transport • positive regulation of cell size • regulation of cellular component size • regulation of cell size • negative regulation of gene expression • response to lipopolysaccharide • response to bacterium • response to molecule of bacterial origin • endothelin receptor signaling pathway involved in heart process • endothelin receptor signaling pathway • G protein-coupled receptor signaling pathway involved in heart process • muscle cell apoptotic process • smooth muscle cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • regulation of smooth muscle cell apoptotic process • negative regulation of smooth muscle cell apoptotic process • negative regulation of apoptotic process • negative regulation of muscle cell apoptotic process • apoptotic process • programmed cell death • phospholipase D-activating G protein-coupled receptor signaling pathway • positive regulation of hormone secretion • meiotic cell cycle process involved in oocyte maturation • sexual reproduction • cellular process involved in reproduction in multicellular organism • developmental process involved in reproduction • female gamete generation • meiotic cell cycle process • gamete generation • oocyte development • cell maturation • meiotic cell cycle • oogenesis • developmental maturation • anatomical structure maturation • germ cell development • oocyte maturation • oocyte differentiation • cell activation • leukocyte activation • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • renal filtration cell differentiation • kidney epithelium development • glomerular epithelial cell differentiation • epithelial cell differentiation • renal system development • nephron development • nephron epithelium development • epithelial cell differentiation involved in kidney development • glomerular epithelium development • glomerulus development • cell differentiation involved in kidney development • podocyte differentiation • kidney development • hexose transmembrane transport • carbohydrate transport • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • regulation of response to external stimulus • regulation of response to wounding • regulation of coagulation • regulation of response to stress • coagulation • response to wounding • regulation of hemostasis • wound healing • negative regulation of wound healing • regulation of blood coagulation • negative regulation of blood coagulation • hemostasis • negative regulation of response to wounding • blood coagulation • negative regulation of hemostasis • negative regulation of coagulation • negative regulation of response to external stimulus • regulation of wound healing • negative regulation of multicellular organismal process • regulation of vasoconstriction • intracellular calcium ion homeostasis • calcium ion homeostasis • cellular homeostasis • intracellular monoatomic cation homeostasis • intracellular chemical homeostasis • intracellular monoatomic ion homeostasis • sympathetic neuron axon guidance • axon guidance • neuron projection guidance • in utero embryonic development • body fluid secretion • regulation of protein metabolic process • protein metabolic process • negative regulation of protein metabolic process • positive regulation of JNK cascade • JNK cascade • positive regulation of MAPK cascade • regulation of JNK cascade • regulation of MAPK cascade • regulation of growth • regulation of cardiac muscle tissue growth • regulation of cell differentiation • muscle cell differentiation • muscle structure development • regulation of organ growth • regulation of heart growth • cardiac muscle tissue growth • muscle tissue development • cardiac cell development • positive regulation of developmental growth • positive regulation of heart growth • heart growth • positive regulation of organ growth • positive regulation of muscle cell differentiation • regulation of muscle cell differentiation • positive regulation of cardiac muscle tissue growth • positive regulation of cell growth involved in cardiac muscle cell development • striated muscle cell differentiation • cardiac muscle cell development • regulation of striated muscle cell differentiation • organ growth • striated muscle tissue development • striated muscle cell development • muscle cell development • positive regulation of cell differentiation • positive regulation of striated muscle cell differentiation • heart development • regulation of multicellular organismal development • regulation of developmental growth • cardiac muscle tissue development • physiological muscle hypertrophy • cardiac muscle cell differentiation • regulation of cell growth involved in cardiac muscle cell development • positive regulation of cell growth • regulation of cell growth • cardiocyte differentiation • cell growth involved in cardiac muscle cell development • positive regulation of growth • physiological cardiac muscle hypertrophy • cellular component biogenesis • cellular anatomical entity morphogenesis • cellular component assembly • sarcomere organization • actin filament-based process • actomyosin structure organization • positive regulation of cytoskeleton organization • positive regulation of supramolecular fiber organization • myofibril assembly • regulation of sarcomere organization • regulation of supramolecular fiber organization • supramolecular fiber organization • regulation of cytoskeleton organization • regulation of actin filament-based process • cellular component assembly involved in morphogenesis • membraneless organelle assembly • actin cytoskeleton organization • organelle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • positive regulation of sarcomere organization • cytoskeleton organization • response to leptin • positive regulation of DNA-templated transcription • positive regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • renal sodium ion transport • renal absorption • renal sodium ion absorption • sodium ion transport • semaphorin-plexin signaling pathway • semaphorin-plexin signaling pathway involved in neuron projection guidance • semaphorin-plexin signaling pathway involved in axon guidance • positive regulation of artery morphogenesis • regulation of artery morphogenesis • response to acid chemical • response to amino acid • cellular response to mineralocorticoid stimulus • response to mineralocorticoid • cellular response to corticosteroid stimulus • cellular response to lipid • cellular response to steroid hormone stimulus • positive regulation of cation transmembrane transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • positive regulation of molecular function • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • positive regulation of monoatomic ion transmembrane transport • regulation of monoatomic ion transport • positive regulation of cation channel activity • regulation of molecular function • positive regulation of transporter activity • positive regulation of ion transmembrane transporter activity • regulation of monoatomic cation transmembrane transport • positive regulation of cytosolic calcium ion concentration • regulation of protein localization • positive regulation of protein localization to nucleus • regulation of protein localization to nucleus • protein localization to nucleus • protein localization to organelle • positive regulation of protein localization • intracellular protein localization • endothelial cell migration • positive regulation of endothelial cell migration • regulation of endothelial cell migration • phosphatidylinositol 3-kinase/protein kinase B signal transduction • cellular response to growth factor stimulus • response to transforming growth factor beta • cellular response to transforming growth factor beta stimulus • response to growth factor • regulation of pH • icosanoid metabolic process • prostaglandin metabolic process • unsaturated fatty acid metabolic process • oxoacid metabolic process • lipid biosynthetic process • organic acid biosynthetic process • organic acid metabolic process • carboxylic acid biosynthetic process • prostanoid metabolic process • icosanoid biosynthetic process • small molecule metabolic process • prostaglandin biosynthetic process • prostanoid biosynthetic process • fatty acid metabolic process • monocarboxylic acid biosynthetic process • small molecule biosynthetic process • carboxylic acid metabolic process • fatty acid biosynthetic process • unsaturated fatty acid biosynthetic process • monocarboxylic acid metabolic process • lipid metabolic process • epithelial fluid transport • transepithelial transport • fluid transport • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • vascular associated smooth muscle cell proliferation • embryonic heart tube development • positive regulation of chemotaxis • positive regulation of neutrophil chemotaxis • taxis • regulation of immune system process • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • neutrophil migration • granulocyte migration • leukocyte migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • myeloid leukocyte migration • cell chemotaxis • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • granulocyte chemotaxis • leukocyte chemotaxis • cellular response to oxidative stress • cellular response to chemical stress • cellular response to hydrogen peroxide • response to hydrogen peroxide • cellular response to reactive oxygen species • cAMP/PKA signal transduction • heart morphogenesis • cardiac neural crest cell development involved in heart development • neural crest cell development • mesenchymal cell migration • ameboidal-type cell migration • neural crest cell migration • stem cell development • cardiac neural crest cell development involved in outflow tract morphogenesis • cell migration involved in heart development • cardiac neural crest cell differentiation involved in heart development • outflow tract morphogenesis • cardiac neural crest cell migration involved in outflow tract morphogenesis • positive regulation of smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • membrane depolarization • regulation of membrane potential • response to fatty acid • cellular response to fatty acid • endothelium development • kidney vasculature development • renal system vasculature development • glomerular endothelium development • glomerulus vasculature development • mitochondrion organization • response to nicotine • innervation • nerve development • axonogenesis involved in innervation • cellular response to glucocorticoid stimulus • response to mechanical stimulus • response to muscle stretch • membrane-bounded organelle • intracellular anatomical structure • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • endoplasmic reticulum lumen • rough endoplasmic reticulum • intracellular organelle • cellular anatomical structure • rough endoplasmic reticulum lumen • organelle lumen • organelle • endoplasmic reticulum
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • endoplasmic reticulum lumen • rough endoplasmic reticulum • intracellular organelle • cellular anatomical structure • rough endoplasmic reticulum lumen • organelle lumen • organelle • endoplasmic reticulum • cytoplasm • extracellular region • extracellular space • intracellular vesicle • cytoplasmic vesicle • Weibel-Palade body • secretory granule • clathrin-coated vesicle • secretory vesicle • coated vesicle • vesicle • transport vesicle • basal part of cell • hydrolase activity, acting on glycosyl bonds • glucosidase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • hydrolase activity • beta-glucosidase activity • catalytic activity • cellulase activity • peptide receptor activity • molecular transducer activity • endothelin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • phosphoric ester hydrolase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • phospholipase C activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • phospholipase activity • lipase activity • carbohydrate metabolic process • catabolic process • glucan catabolic process • beta-glucan metabolic process • carbohydrate catabolic process • primary metabolic process • macromolecule catabolic process • polysaccharide metabolic process • glucan metabolic process • beta-glucan catabolic process • polysaccharide catabolic process • metabolic process • cellular process • cellulose catabolic process • macromolecule metabolic process • cellulose metabolic process • cellular response to stimulus • response to human chorionic gonadotropin • cellular response to human chorionic gonadotropin stimulus • response to stimulus • cellular response to gonadotropin stimulus • response to endogenous stimulus • response to gonadotropin • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • regulation of blood pressure • regulation of cellular process • cell surface receptor signaling pathway • signaling • canonical Wnt signaling pathway • cell communication • signal transduction • Wnt signaling pathway • meiotic cell cycle process involved in oocyte maturation • sexual reproduction • cellular developmental process • reproductive process • cell development • cellular process involved in reproduction in multicellular organism • developmental process involved in reproduction • female gamete generation • meiotic cell cycle process • gamete generation • oocyte development • cell differentiation • anatomical structure development • cell maturation • cell cycle • cell cycle process • developmental process • meiotic cell cycle • multicellular organismal reproductive process • oogenesis • developmental maturation • anatomical structure maturation • germ cell development • oocyte maturation • oocyte differentiation • nervous system development • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • neuron remodeling • neuron development • neuron maturation • system development • cell population proliferation • renal filtration cell differentiation • kidney epithelium development • glomerular epithelial cell differentiation • epithelial cell differentiation • renal system development • nephron development • nephron epithelium development • epithelial cell differentiation involved in kidney development • epithelium development • animal organ development • glomerular epithelium development • tissue development • glomerulus development • cell differentiation involved in kidney development • podocyte differentiation • kidney development • respiratory gaseous exchange by respiratory system • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • regulation of localization • hexose transmembrane transport • regulation of transport • transport • carbohydrate transport • establishment of localization • transmembrane transport • localization • regulation of transmembrane transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • stem cell fate commitment • chordate embryonic development • mesenchyme development • embryo development • neural crest formation • embryo development ending in birth or egg hatching • neural crest cell fate commitment • neural crest cell differentiation • epithelial to mesenchymal transition • anatomical structure morphogenesis • stem cell differentiation • anatomical structure formation involved in morphogenesis • mesenchymal cell differentiation • cell fate commitment • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • renal system process • renal absorption • renal albumin absorption • renal protein absorption • sympathetic nervous system development • autonomic nervous system development • artery development • aorta development • vasculature development • blood vessel development • circulatory system development • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron projection morphogenesis • sympathetic neuron axon guidance • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon guidance • axon development • cell morphogenesis involved in neuron differentiation • neuron projection guidance • nervous system process • neuromuscular process • response to oxidative stress • cellular response to stress • response to stress • cellular response to oxidative stress • cellular response to chemical stress • in utero embryonic development • monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • monoatomic ion transport • monoatomic cation transport • calcium ion transmembrane transport • pigmentation • developmental pigmentation • establishment of protein localization • nitrogen compound transport • protein transmembrane transport • protein transport • macromolecule localization • intracellular protein localization • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • morphogenesis of a branching epithelium • response to wounding • cellular response to follicle-stimulating hormone stimulus • response to follicle-stimulating hormone • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to toxic substance • response to toxic substance • skeletal system development • embryonic skeletal system development • response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • axon extension • developmental growth • cell growth • neuron projection extension • developmental cell growth • growth • developmental growth involved in morphogenesis • mesenchymal cell apoptotic process • apoptotic process • cell death • programmed cell death • pharyngeal arch artery morphogenesis • pharyngeal system development • artery morphogenesis • noradrenergic neuron differentiation • head development • face development • renal sodium ion transport • renal sodium ion absorption • sodium ion transport • response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • semaphorin-plexin signaling pathway • semaphorin-plexin signaling pathway involved in neuron projection guidance • semaphorin-plexin signaling pathway involved in axon guidance • ear morphogenesis • embryonic organ morphogenesis • middle ear morphogenesis • ear development • sensory organ development • embryonic morphogenesis • sensory organ morphogenesis • animal organ morphogenesis • embryonic organ development • mitotic cell cycle • cellular response to nitrogen compound • cellular response to luteinizing hormone stimulus • response to luteinizing hormone • response to peptide hormone • cellular response to peptide hormone stimulus • cellular response to oxygen-containing compound • regulation of protein localization to cell leading edge • regulation of protein localization • protein localization to cell leading edge • positive regulation of cation transmembrane transport • positive regulation of biological process • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of cellular process • regulation of monoatomic ion transport • positive regulation of cation channel activity • positive regulation of transport • positive regulation of transporter activity • positive regulation of ion transmembrane transporter activity • regulation of monoatomic cation transmembrane transport • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • thyroid gland development • endocrine system development • gland development • cranial skeletal system development • carbohydrate derivative metabolic process • protein metabolic process • proteoglycan metabolic process • glycoprotein metabolic process • heparin proteoglycan metabolic process • smooth muscle contraction • muscle contraction • muscle system process • smooth muscle cell differentiation • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • muscle cell development • vascular associated smooth muscle cell development • ventricular cardiac muscle tissue morphogenesis • heart morphogenesis • striated muscle tissue development • left ventricular cardiac muscle tissue morphogenesis • ventricular cardiac muscle tissue development • cardiac chamber development • muscle tissue development • muscle organ development • heart development • cardiac chamber morphogenesis • cardiac muscle tissue development • muscle tissue morphogenesis • cardiac ventricle morphogenesis • cardiac muscle tissue morphogenesis • cardiac left ventricle morphogenesis • cardiac ventricle development • muscle organ morphogenesis • embryonic heart tube development • glomerular filtration • renal filtration • endothelin receptor signaling pathway • biosynthetic process • gene expression • macromolecule biosynthetic process • blood vessel remodeling • tissue remodeling • endothelial cell differentiation • endothelium development • endothelial cell development • epithelial cell development • establishment of endothelial barrier • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • catechol-containing compound metabolic process • norepinephrine metabolic process • biogenic amine metabolic process • cAMP/PKA signal transduction • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • vascular associated smooth muscle contraction • artery smooth muscle contraction • tonic smooth muscle contraction • cardiac neural crest cell development involved in heart development • neural crest cell development • mesenchymal cell migration • ameboidal-type cell migration • cell migration • cell motility • neural crest cell migration • stem cell development • cardiac neural crest cell development involved in outflow tract morphogenesis • cell migration involved in heart development • cardiocyte differentiation • cardiac neural crest cell differentiation involved in heart development • outflow tract morphogenesis • cardiac neural crest cell migration involved in outflow tract morphogenesis • cardiac chamber formation • podocyte apoptotic process • epithelial cell apoptotic process • response to amine • response to amphetamine • enteric nervous system development • sodium ion homeostasis • atrial cardiac muscle tissue development • kidney vasculature development • renal system vasculature development • glomerular endothelium development • glomerulus vasculature development • organelle organization • mitochondrion organization • innervation • nerve development • axonogenesis involved in innervation • endothelin receptor signaling pathway involved in heart process • G protein-coupled receptor signaling pathway involved in heart process • cell surface • cell periphery • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • ectodermal placode formation • skin development • skin epidermis development • hair follicle development • molting cycle • ectodermal placode development • hair cycle process • sensory perception of smell • response to glucagon • cellular response to glucagon stimulus • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of metabolic process • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of peptide hormone secretion • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25101
Sequence	>8XVI_nogp_Chain_R N Y C P Q Q T K I T S A F K Y I N T V I S C T I F I V G M V G N A T L L R I I Y Q N K C M R N G P N A L I A S L A L G D L I Y V V I D L P I N V F K L L A G R W P F D H N D F G V F L C K L F P F L Q K S S V G I T V L N L C A L S V D R Y R A V A S W S R V Q G I G I P L V T A I E I V S I W I L S F I L A I P E A I G F V M V P F E Y R G E Q H K T C M L N A T S K F M E F Y Q D V K D W W L F G F Y F C M P L V C T A I F Y T L M T C E M L N A L S E H L K Q R R E V A K T V F C L V V I F A L C W F P L H L S R I L K K T V Y N E M D K N R C E L L S F L L L M D Y I G I N L A T M N S C I N P I A L Y F V S K K F K N C F Q S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HCQ	A	Peptide	Endothelin	ET_A	Homo sapiens	Endothelin-1	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.01	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8HCQ (No Gprot)	A	Peptide	Endothelin	ET_A	Homo sapiens	Endothelin-1	-		3.01	2023-03-22	doi.org/10.1038/s41467-023-36998-9
	8XVI	A	Peptide	Endothelin	ET_A	Homo sapiens	Endothelin-1	-	chim(Gs-CtGq)/β1/γ2	3.32	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVI (No Gprot)	A	Peptide	Endothelin	ET_A	Homo sapiens	Endothelin-1	-		3.32	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVJ	A	Peptide	Endothelin	ET_A	Homo sapiens	Macitentan	-	-	3.26	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVK	A	Peptide	Endothelin	ET_A	Homo sapiens	Ambrisentan	-	-	3.21	2024-08-28	doi.org/10.1038/s41421-024-00705-9
	8XVL	A	Peptide	Endothelin	ET_A	Homo sapiens	Zibotentan	-	-	3.22	2024-08-28	doi.org/10.1038/s41421-024-00705-9

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