psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H20	R:R:I22	6.63	Yes	No	0	7	4
2	R:R:C23	R:R:H20	13.27	No	Yes	4	8	7
3	R:R:F30	R:R:H20	3.39	Yes	Yes	4	5	7
4	R:R:H20	R:R:P41	6.1	Yes	Yes	4	7	9
5	R:R:D43	R:R:H20	16.39	No	Yes	4	5	7
6	R:R:H20	R:R:L44	7.71	Yes	Yes	4	7	2
7	R:R:I22	R:R:K36	15.99	No	No	0	4	5
8	R:R:C23	R:R:F30	5.59	No	Yes	4	8	5
9	R:R:H24	R:R:S26	8.37	No	No	0	2	4
10	R:R:C25	R:R:F30	8.38	No	Yes	0	8	5
11	R:R:N47	R:R:R28	6.03	No	No	0	5	1
12	R:R:I49	R:R:R28	20.04	No	No	0	3	1
13	R:R:L31	R:R:V29	4.47	No	No	0	4	5
14	R:R:E50	R:R:V29	9.98	No	No	0	4	5
15	R:R:F30	R:R:L44	7.31	Yes	Yes	4	5	2
16	R:R:F30	R:R:P45	14.45	Yes	No	4	5	2
17	R:R:A48	R:R:F30	5.55	No	Yes	4	3	5
18	R:R:F30	R:R:L51	4.87	Yes	Yes	4	5	8
19	R:R:L31	R:R:R52	4.86	No	Yes	0	4	5
20	R:R:C32	R:R:V37	6.83	No	No	0	9	6
21	R:R:C32	R:R:F53	12.57	No	No	0	9	6
22	R:R:E34	R:R:Q33	3.82	No	No	0	2	4
23	R:R:K57	R:R:S35	3.06	No	No	0	3	3
24	R:R:T56	R:R:V37	6.35	No	No	0	6	6
25	R:R:K57	R:R:T38	12.01	No	No	0	3	1
26	R:R:I40	R:R:P41	3.39	Yes	Yes	4	5	9
27	R:R:F53	R:R:I40	7.54	No	Yes	0	6	5
28	R:R:I40	R:R:L58	2.85	Yes	No	0	5	3
29	R:R:I40	R:R:Q62	9.61	Yes	No	4	5	4
30	R:R:A65	R:R:I40	3.25	No	Yes	4	5	5
31	R:R:D43	R:R:P41	4.83	No	Yes	4	5	9
32	R:R:L44	R:R:P41	8.21	Yes	Yes	4	2	9
33	R:R:L44	R:R:P45	3.28	Yes	No	4	2	2
34	R:R:G68	R:R:R46	4.5	No	No	0	4	1
35	R:R:D71	R:R:N47	12.12	No	No	0	4	5
36	R:R:A48	R:R:L51	3.15	No	Yes	4	3	8
37	R:R:E73	R:R:I49	8.2	No	No	0	2	3
38	R:R:E50	R:R:R52	32.56	No	Yes	0	4	5
39	R:R:F69	R:R:L51	3.65	No	Yes	0	6	8
40	R:R:L51	R:R:L72	5.54	Yes	No	0	8	7
41	R:R:K74	R:R:R52	4.95	Yes	Yes	0	3	5
42	R:R:E76	R:R:R52	9.3	No	Yes	0	5	5
43	R:R:E76	R:R:V54	4.28	No	No	14	5	2
44	R:R:S78	R:R:V54	6.46	Yes	No	14	5	2
45	R:R:Q79	R:R:V54	2.87	Yes	No	14	7	2
46	R:R:L58	R:R:T56	2.95	No	No	0	3	6
47	R:R:N80	R:R:T56	7.31	No	No	0	7	6
48	R:R:K57	R:R:R59	6.19	No	No	0	3	2
49	R:R:I61	R:R:L58	2.85	Yes	No	0	8	3
50	R:R:R59	R:R:V82	7.85	No	No	0	2	5
51	R:R:V60	R:R:V85	8.02	No	No	0	4	4
52	R:R:E87	R:R:V60	2.85	No	No	0	6	4
53	R:R:I61	R:R:L83	5.71	Yes	No	0	8	8
54	R:R:I61	R:R:I86	8.83	Yes	Yes	1	8	8
55	R:R:I61	R:R:V90	6.14	Yes	Yes	1	8	9
56	R:R:A65	R:R:Q62	6.06	No	No	4	5	4
57	R:R:G64	R:R:S67	3.71	No	No	0	4	1
58	R:R:F66	R:R:F69	6.43	Yes	No	0	8	6
59	R:R:F66	R:R:I75	12.56	Yes	Yes	1	8	7
60	R:R:F66	R:R:V90	5.24	Yes	Yes	1	8	9
61	R:R:F66	R:R:F91	6.43	Yes	Yes	1	8	9
62	R:R:I75	R:R:L72	8.56	Yes	No	0	7	7
63	R:R:E73	R:R:K96	12.15	No	No	0	2	6
64	R:R:H98	R:R:K74	32.75	No	Yes	7	4	3
65	R:R:E99	R:R:K74	13.5	No	Yes	7	6	3
66	R:R:F91	R:R:I75	8.79	Yes	Yes	1	9	7
67	R:R:I75	R:R:L97	7.14	Yes	Yes	1	7	8
68	R:R:E76	R:R:S78	8.62	No	Yes	14	5	5
69	R:R:I77	R:R:N80	11.33	No	No	0	8	7
70	R:R:I102	R:R:I77	2.94	No	No	0	8	8
71	R:R:Q79	R:R:S78	2.89	Yes	Yes	14	7	5
72	R:R:E103	R:R:S78	5.75	No	Yes	0	5	5
73	R:R:K104	R:R:Q79	23.05	No	Yes	0	6	7
74	R:R:D81	R:R:N106	5.39	No	No	0	7	6
75	R:R:L108	R:R:L83	5.54	Yes	No	0	9	8
76	R:R:E84	R:R:N107	17.09	No	No	0	4	5
77	R:R:V85	R:R:Y110	5.05	No	No	0	4	1
78	R:R:I86	R:R:V90	3.07	Yes	Yes	1	8	9
79	R:R:I86	R:R:L108	8.56	Yes	Yes	1	8	9
80	R:R:I111	R:R:I86	2.94	Yes	Yes	1	9	8
81	R:R:E87	R:R:N112	9.2	No	No	0	6	5
82	R:R:A88	R:R:D89	3.09	No	Yes	12	5	3
83	R:R:A88	R:R:N112	4.69	No	No	0	5	5
84	R:R:A88	R:R:E114	6.03	No	Yes	12	5	6
85	R:R:D89	R:R:S92	4.42	Yes	No	12	3	4
86	R:R:D89	R:R:E114	20.79	Yes	Yes	12	3	6
87	R:R:D89	R:R:Q117	10.44	Yes	No	12	3	5
88	R:R:F91	R:R:V90	3.93	Yes	Yes	1	9	9
89	R:R:F91	R:R:I100	12.56	Yes	Yes	1	9	8
90	R:R:F116	R:R:F91	23.58	Yes	Yes	1	9	9
91	R:R:Q117	R:R:S92	4.33	No	No	12	5	4
92	R:R:N118	R:R:N93	9.54	No	No	0	6	6
93	R:R:L94	R:R:L97	12.46	No	Yes	1	8	8
94	R:R:L119	R:R:L94	4.15	Yes	No	1	8	8
95	R:R:I100	R:R:L97	7.14	Yes	Yes	1	8	8
96	R:R:L119	R:R:L97	5.54	Yes	Yes	1	8	8
97	R:R:E99	R:R:H98	7.39	No	No	7	6	4
98	R:R:H98	R:R:Q123	3.71	No	No	7	4	5
99	R:R:E99	R:R:R101	32.56	No	No	0	6	5
100	R:R:F116	R:R:I100	5.02	Yes	Yes	1	9	8
101	R:R:I100	R:R:L122	2.85	Yes	Yes	1	8	9
102	R:R:I100	R:R:L125	5.71	Yes	No	0	8	8
103	R:R:R101	R:R:Y124	8.23	No	Yes	0	5	6
104	R:R:L126	R:R:R101	7.29	No	No	0	7	5
105	R:R:I102	R:R:I127	2.94	No	No	0	8	9
106	R:R:E103	R:R:K104	6.75	No	No	0	5	6
107	R:R:A105	R:R:L108	3.15	No	Yes	0	8	9
108	R:R:I111	R:R:L108	5.71	Yes	Yes	1	9	9
109	R:R:L108	R:R:T130	4.42	Yes	Yes	1	9	8
110	R:R:I132	R:R:L108	2.85	Yes	Yes	1	7	9
111	R:R:L109	R:R:Y110	3.52	No	No	0	5	1
112	R:R:K133	R:R:L109	9.87	No	No	0	4	5
113	R:R:I111	R:R:I132	11.77	Yes	Yes	1	9	7
114	R:R:I111	R:R:P136	3.39	Yes	No	1	9	9
115	R:R:E114	R:R:Q117	21.66	Yes	No	12	6	5
116	R:R:E114	R:R:K140	5.4	Yes	No	0	6	5
117	R:R:F116	R:R:I141	5.02	Yes	Yes	1	9	8
118	R:R:N118	R:R:P120	3.26	No	No	0	6	8
119	R:R:I141	R:R:L119	4.28	Yes	Yes	1	8	8
120	R:R:L144	R:R:P120	3.28	No	No	0	6	8
121	R:R:N121	R:R:Q145	6.6	No	No	0	4	5
122	R:R:I141	R:R:L122	4.28	Yes	Yes	1	8	9
123	R:R:L122	R:R:S143	3	Yes	No	1	9	8
124	R:R:L122	R:R:V147	2.98	Yes	Yes	1	9	6
125	R:R:Q123	R:R:Y124	4.51	No	Yes	7	5	6
126	R:R:K146	R:R:Q123	9.49	No	No	7	6	5
127	R:R:K146	R:R:Y124	4.78	No	Yes	7	6	6
128	R:R:L148	R:R:Y124	10.55	No	Yes	7	5	6
129	R:R:L125	R:R:L149	4.15	No	Yes	0	8	8
130	R:R:D150	R:R:L126	10.86	No	No	0	7	7
131	R:R:I127	R:R:T130	3.04	No	Yes	0	9	8
132	R:R:Q152	R:R:S128	5.78	Yes	No	0	7	7
133	R:R:I132	R:R:T130	12.16	Yes	Yes	1	7	8
134	R:R:N154	R:R:T130	5.85	Yes	Yes	1	9	8
135	R:R:G131	R:R:N156	6.79	No	No	0	5	4
136	R:R:I132	R:R:P136	3.39	Yes	No	1	7	9
137	R:R:I132	R:R:N154	5.66	Yes	Yes	1	7	9
138	R:R:K133	R:R:N156	12.59	No	No	0	4	4
139	R:R:L135	R:R:P136	3.28	Yes	No	0	7	9
140	R:R:I151	R:R:L135	2.85	Yes	Yes	0	7	7
141	R:R:I157	R:R:L135	7.14	No	Yes	0	7	7
142	R:R:I160	R:R:L135	2.85	Yes	Yes	0	6	7
143	R:R:D137	R:R:H139	3.78	No	No	0	7	6
144	R:R:I141	R:R:V138	4.61	Yes	No	1	8	7
145	R:R:L168	R:R:V138	10.43	Yes	No	1	5	7
146	R:R:H139	R:R:V166	5.54	No	Yes	0	6	1
147	R:R:G167	R:R:H139	4.77	No	No	0	5	6
148	R:R:H142	R:R:K140	3.93	No	No	0	4	5
149	R:R:I141	R:R:L168	4.28	Yes	Yes	1	8	5
150	R:R:S143	R:R:V147	3.23	No	Yes	1	8	6
151	R:R:S143	R:R:S169	6.52	No	Yes	1	8	4
152	R:R:L144	R:R:Q145	3.99	No	No	0	6	5
153	R:R:F170	R:R:L144	3.65	No	No	0	3	6
154	R:R:K146	R:R:L148	5.64	No	No	7	6	5
155	R:R:L149	R:R:V147	2.98	Yes	Yes	1	8	6
156	R:R:L168	R:R:V147	5.96	Yes	Yes	1	5	6
157	R:R:S169	R:R:V147	4.85	Yes	Yes	1	4	6
158	R:R:V147	R:R:V173	4.81	Yes	No	1	6	4
159	R:R:I174	R:R:L148	7.14	No	No	7	5	5
160	R:R:L149	R:R:L168	8.3	Yes	Yes	1	8	5
161	R:R:L149	R:R:L175	5.54	Yes	Yes	1	8	7
162	R:R:D150	R:R:Q152	14.36	No	Yes	6	7	7
163	R:R:D150	R:R:W176	27.92	No	Yes	6	7	6
164	R:R:I151	R:R:N154	2.83	Yes	Yes	1	7	9
165	R:R:I151	R:R:L177	5.71	Yes	Yes	1	7	9
166	R:R:I151	R:R:N180	5.66	Yes	Yes	1	7	9
167	R:R:D153	R:R:Q152	3.92	No	Yes	6	6	7
168	R:R:Q152	R:R:W176	6.57	Yes	Yes	6	7	6
169	R:R:K179	R:R:Q152	4.07	Yes	Yes	6	6	7
170	R:R:D153	R:R:K179	4.15	No	Yes	6	6	6
171	R:R:I157	R:R:N154	18.41	No	Yes	0	7	9
172	R:R:I160	R:R:S164	3.1	Yes	No	0	6	6
173	R:R:I160	R:R:I182	8.83	Yes	No	0	6	8
174	R:R:I160	R:R:I185	7.36	Yes	Yes	0	6	7
175	R:R:E161	R:R:S164	12.94	No	No	0	6	6
176	R:R:N163	R:R:R162	7.23	No	Yes	11	7	4
177	R:R:N187	R:R:R162	19.28	No	Yes	11	4	4
178	R:R:C188	R:R:R162	5.57	Yes	Yes	11	4	4
179	R:R:N191	R:R:R162	3.62	Yes	Yes	11	5	4
180	R:R:N163	R:R:V166	8.87	No	Yes	11	7	1
181	R:R:N163	R:R:N191	19.07	No	Yes	11	7	5
182	R:R:F165	R:R:L175	20.7	No	Yes	1	7	7
183	R:R:F165	R:R:L177	6.09	No	Yes	1	7	9
184	R:R:F165	R:R:F190	11.79	No	Yes	1	7	9
185	R:R:N191	R:R:V166	7.39	Yes	Yes	11	5	1
186	R:R:L168	R:R:V173	2.98	Yes	No	1	5	4
187	R:R:S169	R:R:V173	3.23	Yes	No	1	4	4
188	R:R:D196	R:R:S172	2.94	Yes	No	0	4	5
189	R:R:D196	R:R:I174	5.6	Yes	No	7	4	5
190	R:R:E197	R:R:I174	6.83	No	No	7	5	5
191	R:R:F190	R:R:L175	4.87	Yes	Yes	1	9	7
192	R:R:L175	R:R:L195	6.92	Yes	Yes	1	7	9
193	R:R:N178	R:R:W176	23.73	No	Yes	6	5	6
194	R:R:N199	R:R:W176	15.82	Yes	Yes	6	5	6
195	R:R:L177	R:R:N180	5.49	Yes	Yes	1	9	9
196	R:R:L177	R:R:L200	4.15	Yes	No	0	9	9
197	R:R:K179	R:R:N178	9.79	Yes	No	6	6	5
198	R:R:N178	R:R:N199	13.62	No	Yes	6	5	5
199	R:R:D202	R:R:K179	9.68	No	Yes	0	5	6
200	R:R:I182	R:R:N180	4.25	No	Yes	0	8	9
201	R:R:I182	R:R:N203	5.66	No	No	0	8	9
202	R:R:E184	R:R:Q183	6.37	No	No	0	4	1
203	R:R:E207	R:R:Q183	3.82	No	No	0	1	1
204	R:R:E184	R:R:E208	8.88	No	No	0	4	1
205	R:R:I185	R:R:L206	2.85	Yes	Yes	1	7	8
206	R:R:I185	R:R:L209	4.28	Yes	Yes	1	7	7
207	R:R:I185	R:R:P210	3.39	Yes	No	0	7	6
208	R:R:C188	R:R:N187	3.15	Yes	No	11	4	4
209	R:R:C188	R:R:N191	4.72	Yes	Yes	11	4	5
210	R:R:C188	R:R:H215	4.42	Yes	No	0	4	2
211	R:R:F190	R:R:T193	3.89	Yes	No	1	9	5
212	R:R:F190	R:R:L195	15.83	Yes	Yes	1	9	9
213	R:R:F190	R:R:L198	4.87	Yes	Yes	1	9	7
214	R:R:F190	R:R:F214	3.22	Yes	Yes	1	9	9
215	R:R:L195	R:R:T193	7.37	Yes	No	1	9	5
216	R:R:Q194	R:R:S218	2.89	No	No	0	5	3
217	R:R:L195	R:R:P220	4.93	Yes	Yes	1	9	8
218	R:R:D196	R:R:E197	6.5	Yes	No	7	4	5
219	R:R:D196	R:R:V221	2.92	Yes	Yes	0	4	1
220	R:R:E197	R:R:I222	16.4	No	No	0	5	3
221	R:R:L198	R:R:L200	15.22	Yes	No	0	7	9
222	R:R:L198	R:R:P220	3.28	Yes	Yes	1	7	8
223	R:R:L198	R:R:L223	4.15	Yes	No	1	7	8
224	R:R:N199	R:R:S201	2.98	Yes	No	6	5	7
225	R:R:D224	R:R:N199	12.12	Yes	Yes	6	9	5
226	R:R:D224	R:R:S201	10.31	Yes	No	6	9	7
227	R:R:S201	R:R:S226	4.89	No	No	6	7	8
228	R:R:D202	R:R:R227	5.96	No	No	0	5	7
229	R:R:L206	R:R:N203	15.1	Yes	No	0	8	9
230	R:R:L206	R:R:L209	8.3	Yes	Yes	1	8	7
231	R:R:L206	R:R:T228	4.42	Yes	Yes	1	8	9
232	R:R:I230	R:R:L206	8.56	Yes	Yes	1	8	8
233	R:R:I230	R:R:L209	9.99	Yes	Yes	1	8	7
234	R:R:L209	R:R:P234	4.93	Yes	Yes	1	7	9
235	R:R:P210	R:R:V213	7.07	No	Yes	0	6	8
236	R:R:N211	R:R:S235	5.96	No	No	0	2	4
237	R:R:F214	R:R:V213	9.18	Yes	Yes	1	9	8
238	R:R:P234	R:R:V213	3.53	Yes	Yes	1	9	8
239	R:R:F214	R:R:P220	13	Yes	Yes	1	9	8
240	R:R:F214	R:R:P234	2.89	Yes	Yes	1	9	9
241	R:R:F214	R:R:G237	3.01	Yes	No	0	9	8
242	R:R:F214	R:R:L238	4.87	Yes	No	0	9	8
243	R:R:G219	R:R:P220	4.06	No	Yes	0	6	8
244	R:R:G219	R:R:N240	3.39	No	No	0	6	4
245	R:R:L223	R:R:P220	8.21	No	Yes	1	8	8
246	R:R:I222	R:R:V221	3.07	No	Yes	0	3	1
247	R:R:N240	R:R:V221	5.91	No	Yes	0	4	1
248	R:R:K242	R:R:V221	4.55	No	Yes	0	6	1
249	R:R:I222	R:R:K243	8.72	No	No	0	3	5
250	R:R:L223	R:R:L241	13.84	No	No	0	8	7
251	R:R:D224	R:R:S226	4.42	Yes	No	6	9	8
252	R:R:D224	R:R:R245	3.57	Yes	No	0	9	4
253	R:R:I225	R:R:T228	6.08	No	Yes	1	8	9
254	R:R:I225	R:R:I230	4.42	No	Yes	1	8	8
255	R:R:A246	R:R:I225	3.25	No	No	0	8	8
256	R:R:R247	R:R:S226	3.95	Yes	No	0	4	8
257	R:R:R227	R:R:S248	6.59	No	No	0	7	7
258	R:R:I230	R:R:T228	7.6	Yes	Yes	1	8	9
259	R:R:T228	R:R:T249	4.71	Yes	No	0	9	7
260	R:R:R229	R:R:Y250	5.14	No	Yes	0	4	3
261	R:R:N251	R:R:R229	30.13	No	No	0	5	4
262	R:R:H231	R:R:N251	5.1	No	No	0	4	5
263	R:R:L233	R:R:P234	4.93	No	Yes	0	8	9
264	R:R:L233	R:R:L252	4.15	No	No	0	8	8
265	R:R:L233	R:R:P256	6.57	No	No	0	8	7
266	R:R:S235	R:R:Y236	10.17	No	No	18	4	2
267	R:R:K260	R:R:S235	3.06	No	No	18	4	4
268	R:R:K260	R:R:Y236	7.17	No	No	18	4	2
269	R:R:E239	R:R:G237	4.91	No	No	0	3	8
270	R:R:L238	R:R:L241	4.15	No	No	0	8	7
271	R:R:L238	R:R:L261	4.15	No	No	0	8	7
272	R:R:L241	R:R:L244	6.92	No	No	0	7	9
273	R:R:A263	R:R:K242	4.82	No	No	0	3	6
274	R:R:K242	R:R:M265	7.2	No	No	0	6	5
275	R:R:K243	R:R:R245	14.85	No	No	0	5	4
276	R:R:E266	R:R:K243	10.8	No	No	0	4	5
277	R:R:R245	R:R:S268	3.95	No	No	0	4	5
278	R:R:A246	R:R:T249	5.03	No	No	0	8	7
279	R:R:R247	R:R:S268	6.59	Yes	No	0	4	5
280	R:R:P348	R:R:R247	4.32	No	Yes	0	9	4
281	R:R:L252	R:R:T249	4.42	No	No	0	8	7
282	R:R:K253	R:R:Y250	19.11	No	Yes	15	6	3
283	R:R:Y250	R:R:Y271	12.91	Yes	No	15	3	9
284	R:R:T438	R:R:Y250	4.99	Yes	Yes	15	5	3
285	R:R:M512	R:R:Y250	9.58	No	Yes	0	5	3
286	R:R:L252	R:R:L255	9.69	No	Yes	0	8	6
287	R:R:K253	R:R:Y271	10.75	No	No	15	6	9
288	R:R:K253	R:R:T438	4.5	No	Yes	15	6	5
289	R:R:L255	R:R:P256	3.28	Yes	No	0	6	7
290	R:R:L255	R:R:L269	4.15	Yes	No	0	6	7
291	R:R:H274	R:R:L255	3.86	No	Yes	0	9	6
292	R:R:E259	R:R:T257	8.47	No	No	0	4	4
293	R:R:K260	R:R:T257	6.01	No	No	0	4	4
294	R:R:F278	R:R:L258	10.96	Yes	No	13	8	6
295	R:R:L258	R:R:W281	13.67	No	No	13	6	5
296	R:R:L261	R:R:L264	4.15	No	No	0	7	6
297	R:R:E266	R:R:T345	8.47	No	No	0	4	3
298	R:R:A267	R:R:C346	3.61	No	Yes	0	8	9
299	R:R:S268	R:R:S347	3.26	No	No	0	5	6
300	R:R:H274	R:R:Y271	9.8	No	No	0	9	9
301	R:R:P272	R:R:P348	7.79	No	No	0	7	9
302	R:R:A433	R:R:S273	3.42	No	No	0	9	8
303	R:R:I434	R:R:S273	3.1	Yes	No	0	7	8
304	R:R:H274	R:R:I434	9.28	No	Yes	0	9	7
305	R:R:C275	R:R:P350	9.41	No	No	0	9	8
306	R:R:C276	R:R:P350	3.77	No	No	0	9	8
307	R:R:C276	R:R:C356	7.28	No	Yes	0	9	9
308	R:R:F278	R:R:W281	5.01	Yes	No	13	8	5
309	R:R:F278	R:R:V344	11.8	Yes	No	13	8	5
310	R:R:C346	R:R:F278	5.59	Yes	Yes	13	9	8
311	R:R:I285	R:R:W281	19.97	No	No	0	1	5
312	R:R:R282	R:R:S286	3.95	No	No	0	4	4
313	R:R:R283	R:R:S286	9.22	No	No	0	3	4
314	R:R:E287	R:R:R283	23.26	No	No	0	2	3
315	R:R:C346	R:R:V344	3.42	Yes	No	13	9	5
316	R:R:K349	R:R:P350	3.35	No	No	0	3	8
317	R:R:D351	R:R:F353	9.55	No	No	0	8	8
318	R:R:A352	R:R:V604	3.39	No	No	0	8	8
319	R:R:A352	R:R:S605	3.42	No	No	0	8	7
320	R:R:F353	R:R:V604	27.53	No	No	0	8	8
321	R:R:N354	R:R:Q437	5.28	No	No	0	8	9
322	R:R:N354	R:R:V514	4.43	No	No	0	8	8
323	R:R:P355	R:R:S515	5.34	No	Yes	3	9	9
324	R:R:K608	R:R:P355	3.35	Yes	No	3	9	9
325	R:R:C356	R:R:E357	9.12	Yes	No	0	9	7
326	R:R:C356	R:R:H430	2.95	Yes	No	0	9	7
327	R:R:D358	R:R:G361	3.35	No	No	0	7	8
328	R:R:D358	R:R:D422	15.97	No	Yes	0	7	9
329	R:R:D422	R:R:I359	8.4	Yes	Yes	3	9	8
330	R:R:I359	R:R:Y429	14.51	Yes	Yes	3	8	9
331	R:R:I359	R:R:S515	7.74	Yes	Yes	3	8	9
332	R:R:I359	R:R:K608	2.91	Yes	Yes	3	8	9
333	R:R:M360	R:R:R366	4.96	Yes	Yes	3	7	9
334	R:R:I369	R:R:M360	10.2	Yes	Yes	3	8	7
335	R:R:D422	R:R:M360	9.7	Yes	Yes	3	9	7
336	R:R:M360	R:R:V612	6.09	Yes	No	3	7	8
337	R:R:L365	R:R:Y362	7.03	No	No	16	8	7
338	R:R:I609	R:R:Y362	7.25	Yes	No	16	8	7
339	R:R:I364	R:R:L368	2.85	No	No	0	4	6
340	R:R:I609	R:R:L365	14.27	Yes	No	16	8	8
341	R:R:L365	R:R:L613	4.15	No	No	16	8	7
342	R:R:D422	R:R:R366	4.76	Yes	Yes	3	9	9
343	R:R:I423	R:R:R366	8.77	No	Yes	3	5	9
344	R:R:K426	R:R:R366	13.61	No	Yes	3	5	9
345	R:R:I369	R:R:L415	4.28	Yes	Yes	0	8	8
346	R:R:A419	R:R:I369	3.25	No	Yes	0	9	8
347	R:R:I369	R:R:V612	10.75	Yes	No	3	8	8
348	R:R:I374	R:R:W370	21.14	No	No	0	4	9
349	R:R:F371	R:R:L375	18.27	No	No	0	4	6
350	R:R:I372	R:R:L415	2.85	No	Yes	0	8	8
351	R:R:L415	R:R:S373	4.5	Yes	No	0	8	5
352	R:R:L416	R:R:S373	7.51	No	No	0	6	5
353	R:R:I377	R:R:I381	2.94	Yes	No	17	5	3
354	R:R:I377	R:R:L409	4.28	Yes	Yes	17	5	5
355	R:R:I377	R:R:I413	2.94	Yes	No	17	5	4
356	R:R:I377	R:R:L416	2.85	Yes	No	0	5	6
357	R:R:G379	R:R:T378	3.64	No	No	0	7	3
358	R:R:D408	R:R:N380	8.08	Yes	No	0	9	9
359	R:R:L409	R:R:N380	8.24	Yes	No	0	5	9
360	R:R:I381	R:R:L409	2.85	No	Yes	17	3	5
361	R:R:I382	R:R:I386	2.94	No	No	0	5	7
362	R:R:L387	R:R:V383	2.98	No	No	0	5	9
363	R:R:A405	R:R:V383	3.39	No	No	0	8	9
364	R:R:P623	R:R:V383	3.53	No	No	0	9	9
365	R:R:A405	R:R:L384	3.15	No	No	0	8	6
366	R:R:T389	R:R:V385	3.17	No	No	0	4	2
367	R:R:F637	R:R:I386	5.02	No	No	0	4	7
368	R:R:I386	R:R:L640	2.85	No	No	0	7	7
369	R:R:L387	R:R:R398	19.44	No	Yes	5	5	8
370	R:R:F633	R:R:L387	4.87	Yes	No	5	8	5
371	R:R:T388	R:R:T389	3.14	No	No	0	4	4
372	R:R:L640	R:R:T389	7.37	No	No	0	7	4
373	R:R:S390	R:R:Y392	3.82	No	No	5	8	3
374	R:R:R398	R:R:S390	7.91	Yes	No	5	8	8
375	R:R:D636	R:R:S390	7.36	No	No	5	8	8
376	R:R:D636	R:R:Y392	4.6	No	No	5	8	3
377	R:R:K393	R:R:L483	5.64	No	No	0	5	3
378	R:R:L394	R:R:R398	4.86	No	Yes	0	5	8
379	R:R:P397	R:R:T395	6.99	No	No	0	6	7
380	R:R:P397	R:R:V396	3.53	No	Yes	0	6	8
381	R:R:L400	R:R:V396	2.98	No	Yes	0	8	8
382	R:R:L483	R:R:V396	4.47	No	Yes	0	3	8
383	R:R:A486	R:R:V396	5.09	No	Yes	0	7	8
384	R:R:E466	R:R:P397	3.14	No	No	0	9	6
385	R:R:F633	R:R:R398	8.55	Yes	Yes	5	8	8
386	R:R:F399	R:R:M490	4.98	No	Yes	0	7	7
387	R:R:I463	R:R:L400	15.7	No	No	0	9	8
388	R:R:L400	R:R:M490	2.83	No	Yes	0	8	7
389	R:R:M401	R:R:Y626	31.13	No	Yes	5	8	9
390	R:R:F633	R:R:M401	8.71	Yes	No	5	8	8
391	R:R:C402	R:R:N403	3.15	No	No	0	7	8
392	R:R:N403	R:R:T459	2.92	No	No	0	8	8
393	R:R:M490	R:R:N403	15.43	Yes	No	0	7	8
394	R:R:D408	R:R:L404	8.14	Yes	No	8	9	8
395	R:R:L404	R:R:T459	2.95	No	No	0	8	8
396	R:R:L404	R:R:N622	6.87	No	No	8	8	9
397	R:R:C410	R:R:F406	5.59	No	No	0	7	5
398	R:R:D408	R:R:S619	7.36	Yes	No	0	9	9
399	R:R:D408	R:R:N622	9.42	Yes	No	8	9	9
400	R:R:I413	R:R:L409	5.71	No	Yes	17	4	5
401	R:R:A452	R:R:I411	4.87	No	Yes	0	8	7
402	R:R:H615	R:R:I411	5.3	No	Yes	0	6	7
403	R:R:I411	R:R:S619	3.1	Yes	No	0	7	9
404	R:R:I413	R:R:L417	2.85	No	No	0	4	5
405	R:R:I418	R:R:Y414	16.92	No	Yes	0	8	7
406	R:R:A445	R:R:Y414	8.01	No	Yes	9	8	7
407	R:R:G446	R:R:Y414	2.9	No	Yes	9	9	7
408	R:R:T449	R:R:Y414	18.73	No	Yes	0	8	7
409	R:R:C517	R:R:Y414	8.06	Yes	Yes	9	9	7
410	R:R:L415	R:R:P616	3.28	Yes	No	0	8	9
411	R:R:V421	R:R:W436	24.52	No	Yes	0	7	9
412	R:R:I423	R:R:K426	4.36	No	No	3	5	5
413	R:R:T425	R:R:Y429	7.49	No	Yes	0	9	9
414	R:R:T425	R:R:Y432	4.99	No	No	0	9	5
415	R:R:Q428	R:R:S427	7.22	No	No	0	5	7
416	R:R:H430	R:R:Q428	3.71	No	No	19	7	5
417	R:R:N431	R:R:Q428	3.96	No	No	19	5	5
418	R:R:A433	R:R:Y429	4	No	Yes	0	9	9
419	R:R:W436	R:R:Y429	7.72	Yes	Yes	3	9	9
420	R:R:Q437	R:R:Y429	3.38	No	Yes	3	9	9
421	R:R:S515	R:R:Y429	3.82	Yes	Yes	3	9	9
422	R:R:H430	R:R:N431	19.13	No	No	19	7	5
423	R:R:I434	R:R:T438	3.04	Yes	Yes	0	7	5
424	R:R:Q437	R:R:W436	3.29	No	Yes	3	9	9
425	R:R:C442	R:R:D443	3.11	No	No	0	9	4
426	R:R:A445	R:R:C517	3.61	No	Yes	9	8	9
427	R:R:G446	R:R:Y511	5.79	No	Yes	9	9	8
428	R:R:C517	R:R:G446	3.92	Yes	No	9	9	9
429	R:R:F447	R:R:F451	4.29	Yes	Yes	10	8	8
430	R:R:F447	R:R:F498	7.5	Yes	No	10	8	4
431	R:R:A501	R:R:F447	9.71	No	Yes	0	9	8
432	R:R:F447	R:R:L502	14.61	Yes	No	10	8	3
433	R:R:F447	R:R:I505	6.28	Yes	No	0	8	7
434	R:R:A501	R:R:V450	3.39	No	No	0	9	8
435	R:R:V450	R:R:Y511	6.31	No	Yes	9	8	8
436	R:R:P519	R:R:V450	3.53	No	No	9	9	8
437	R:R:F451	R:R:L455	18.27	Yes	No	10	8	7
438	R:R:F451	R:R:W494	14.03	Yes	No	10	8	6
439	R:R:A497	R:R:F451	5.55	No	Yes	10	7	8
440	R:R:F451	R:R:F498	3.22	Yes	No	10	8	4
441	R:R:E454	R:R:F496	9.33	No	No	0	8	5
442	R:R:A497	R:R:E454	3.02	No	No	0	7	8
443	R:R:L455	R:R:W494	6.83	No	No	10	7	6
444	R:R:A497	R:R:L455	4.73	No	No	10	7	7
445	R:R:N538	R:R:V457	4.43	No	No	0	9	8
446	R:R:T461	R:R:Y458	3.75	No	No	0	8	7
447	R:R:V489	R:R:Y458	8.83	No	No	0	5	7
448	R:R:G493	R:R:Y458	11.59	No	No	0	8	7
449	R:R:D581	R:R:L460	12.21	No	No	0	9	9
450	R:R:I545	R:R:T461	6.08	Yes	No	0	8	8
451	R:R:I463	R:R:M574	5.83	No	Yes	0	9	9
452	R:R:I545	R:R:T464	16.72	Yes	Yes	2	8	8
453	R:R:C548	R:R:T464	5.07	Yes	Yes	2	6	8
454	R:R:T464	R:R:Y549	13.73	Yes	Yes	2	8	9
455	R:R:M574	R:R:T464	3.01	Yes	Yes	2	9	8
456	R:R:I578	R:R:T464	3.04	No	Yes	2	9	8
457	R:R:E466	R:R:T470	9.88	No	Yes	2	9	8
458	R:R:D478	R:R:E466	23.39	No	No	2	4	9
459	R:R:R467	R:R:T470	6.47	Yes	Yes	2	9	8
460	R:R:I471	R:R:R467	7.52	Yes	Yes	2	8	9
461	R:R:I570	R:R:R467	20.04	No	Yes	0	7	9
462	R:R:M574	R:R:R467	6.2	Yes	Yes	2	9	9
463	R:R:H469	R:R:W468	10.58	Yes	Yes	2	5	5
464	R:R:T472	R:R:W468	21.83	No	Yes	2	5	5
465	R:R:H473	R:R:W468	4.23	Yes	Yes	2	4	5
466	R:R:C548	R:R:W468	3.92	Yes	Yes	2	6	5
467	R:R:H551	R:R:W468	3.17	No	Yes	0	4	5
468	R:R:I552	R:R:W468	4.7	Yes	Yes	2	8	5
469	R:R:H469	R:R:H473	3.58	Yes	Yes	2	5	4
470	R:R:C479	R:R:H469	10.32	No	Yes	2	6	5
471	R:R:I471	R:R:T470	3.04	Yes	Yes	2	8	8
472	R:R:D478	R:R:T470	8.67	No	Yes	2	4	8
473	R:R:I471	R:R:I552	13.25	Yes	Yes	2	8	8
474	R:R:I471	R:R:T555	4.56	Yes	No	2	8	6
475	R:R:H473	R:R:T472	9.58	Yes	No	2	4	5
476	R:R:C479	R:R:H473	10.32	No	Yes	2	6	4
477	R:R:C479	R:R:Q476	3.05	No	No	0	6	5
478	R:R:K480	R:R:Q476	20.34	No	No	0	7	5
479	R:R:D478	R:R:V481	16.07	No	No	0	4	6
480	R:R:R484	R:R:S488	3.95	No	No	0	4	3
481	R:R:H485	R:R:S488	4.18	No	No	0	5	3
482	R:R:H485	R:R:V489	6.92	No	No	0	5	5
483	R:R:I495	R:R:V491	3.07	No	No	0	1	1
484	R:R:F498	R:R:L502	18.27	No	No	10	4	3
485	R:R:F506	R:R:L502	7.31	No	No	0	3	3
486	R:R:F503	R:R:I508	5.02	Yes	No	20	7	6
487	R:R:F503	R:R:Y530	22.69	Yes	Yes	20	7	7
488	R:R:P504	R:R:Y511	23.64	No	Yes	0	9	8
489	R:R:I508	R:R:L526	8.56	No	No	0	6	4
490	R:R:I508	R:R:Y530	3.63	No	Yes	20	6	7
491	R:R:D521	R:R:S509	4.42	Yes	No	0	8	8
492	R:R:S509	R:R:S527	4.89	No	No	0	8	7
493	R:R:M512	R:R:S510	6.13	No	No	0	5	6
494	R:R:D521	R:R:S510	2.94	Yes	No	0	8	6
495	R:R:P519	R:R:Y511	16.69	No	Yes	9	9	8
496	R:R:D521	R:R:K513	5.53	Yes	No	0	8	5
497	R:R:I516	R:R:V514	7.68	No	No	0	8	8
498	R:R:M520	R:R:V514	3.04	No	No	0	8	8
499	R:R:K608	R:R:S515	6.12	Yes	Yes	3	9	9
500	R:R:I516	R:R:L518	14.27	No	No	0	8	8
501	R:R:I516	R:R:K608	4.36	No	Yes	0	8	9
502	R:R:L518	R:R:P519	3.28	No	No	0	8	9
503	R:R:L518	R:R:L611	4.15	No	No	0	8	7
504	R:R:D521	R:R:D523	13.31	Yes	No	0	8	5
505	R:R:I522	R:R:Q528	4.12	Yes	No	21	6	6
506	R:R:I522	R:R:V531	3.07	Yes	No	0	6	7
507	R:R:I522	R:R:K598	4.36	Yes	No	21	6	5
508	R:R:D523	R:R:S524	4.42	No	Yes	0	5	5
509	R:R:S524	R:R:S527	4.89	Yes	No	0	5	7
510	R:R:M532	R:R:Q528	5.44	No	No	0	6	6
511	R:R:K598	R:R:Q528	4.07	No	No	21	5	6
512	R:R:S533	R:R:Y530	5.09	No	Yes	0	4	7
513	R:R:L534	R:R:Y530	21.1	No	Yes	0	6	7
514	R:R:L535	R:R:V531	2.98	No	No	0	8	7
515	R:R:M532	R:R:S596	3.07	No	No	0	6	7
516	R:R:A592	R:R:L535	4.73	No	No	0	8	8
517	R:R:I593	R:R:L535	2.85	No	No	0	7	8
518	R:R:L540	R:R:V536	2.98	No	No	0	4	5
519	R:R:F542	R:R:M585	11.2	No	No	0	9	7
520	R:R:C546	R:R:V543	3.42	No	No	0	7	4
521	R:R:C548	R:R:I545	3.27	Yes	Yes	2	6	8
522	R:R:I545	R:R:Y549	9.67	Yes	Yes	2	8	9
523	R:R:I545	R:R:I578	5.89	Yes	No	2	8	9
524	R:R:C546	R:R:G547	3.92	No	No	0	7	2
525	R:R:G547	R:R:I550	3.53	No	No	0	2	5
526	R:R:G547	R:R:H551	3.18	No	No	0	2	4
527	R:R:C548	R:R:Y549	5.38	Yes	Yes	2	6	9
528	R:R:M574	R:R:Y549	14.37	Yes	Yes	2	9	9
529	R:R:I578	R:R:Y549	30.22	No	Yes	2	9	9
530	R:R:I550	R:R:L554	2.85	No	No	0	5	4
531	R:R:I552	R:R:T555	3.04	Yes	No	2	8	6
532	R:R:R557	R:R:Y553	39.1	No	No	0	5	8
533	R:R:L554	R:R:R557	3.64	No	No	0	4	5
534	R:R:S563	R:R:V556	6.46	No	No	0	5	8
535	R:R:N558	R:R:P559	8.15	No	No	0	7	7
536	R:R:N558	R:R:N560	4.09	No	No	0	7	5
537	R:R:D567	R:R:S563	2.94	No	No	0	8	5
538	R:R:D567	R:R:S564	10.31	No	No	0	8	5
539	R:R:R569	R:R:R573	21.32	No	No	5	6	9
540	R:R:R569	R:R:T630	5.17	No	No	5	6	9
541	R:R:A575	R:R:K572	3.21	No	No	0	9	8
542	R:R:K572	R:R:M576	7.2	No	No	0	8	5
543	R:R:R573	R:R:Y626	21.61	No	Yes	5	9	9
544	R:R:R573	R:R:T630	12.94	No	No	5	9	9
545	R:R:L625	R:R:M576	5.65	Yes	No	8	8	5
546	R:R:F629	R:R:M576	3.73	Yes	No	8	6	5
547	R:R:L577	R:R:Y626	5.86	No	Yes	0	9	9
548	R:R:F579	R:R:L583	18.27	No	No	0	7	6
549	R:R:D581	R:R:T580	2.89	No	No	8	9	8
550	R:R:N618	R:R:T580	7.31	Yes	No	8	9	8
551	R:R:L625	R:R:T580	7.37	Yes	No	8	8	8
552	R:R:D581	R:R:N618	14.81	No	Yes	8	9	9
553	R:R:A586	R:R:F582	6.93	No	No	0	7	8
554	R:R:C584	R:R:I617	3.27	No	No	0	9	7
555	R:R:C584	R:R:N618	7.87	No	Yes	0	9	9
556	R:R:I588	R:R:L611	5.71	No	No	0	9	7
557	R:R:F591	R:R:I602	23.86	No	No	0	8	8
558	R:R:F591	R:R:L610	4.87	No	No	0	8	8
559	R:R:L601	R:R:S594	6.01	No	No	0	6	8
560	R:R:L597	R:R:S596	4.5	No	No	0	5	7
561	R:R:L601	R:R:V599	2.98	No	No	0	6	5
562	R:R:A607	R:R:I602	3.25	No	No	0	7	8
563	R:R:K608	R:R:V604	3.04	Yes	No	0	9	8
564	R:R:I609	R:R:K606	7.27	Yes	No	0	8	6
565	R:R:K606	R:R:L610	11.28	No	No	0	6	8
566	R:R:I609	R:R:L613	2.85	Yes	No	16	8	7
567	R:R:F614	R:R:L610	8.53	No	No	0	7	8
568	R:R:H615	R:R:P616	6.1	No	No	0	6	9
569	R:R:N618	R:R:N622	10.9	Yes	No	8	9	9
570	R:R:A621	R:R:L625	3.15	No	Yes	0	7	8
571	R:R:F624	R:R:I628	7.54	No	No	0	8	7
572	R:R:F624	R:R:F629	34.29	No	Yes	0	8	6
573	R:R:F629	R:R:L625	4.87	Yes	Yes	8	6	8
574	R:R:F633	R:R:Y626	3.09	Yes	Yes	5	8	9
575	R:R:A627	R:R:F633	9.71	No	Yes	0	7	8
576	R:R:F629	R:R:R634	3.21	Yes	No	0	6	7
577	R:R:F633	R:R:T630	11.67	Yes	No	5	8	9
578	R:R:K631	R:R:R634	4.95	No	No	0	7	7
579	R:R:K631	R:R:R635	9.9	No	No	0	7	5
580	R:R:N632	R:R:R635	10.85	No	No	0	6	5
581	R:R:F637	R:R:L641	18.27	No	No	0	4	4
582	R:R:K643	R:R:L640	4.23	No	No	0	5	7
583	R:R:E39	R:R:T38	2.82	No	No	0	3	1
584	R:R:G441	R:R:W436	2.81	No	Yes	0	7	9
585	R:R:A115	R:R:F116	2.77	No	Yes	0	8	9
586	R:R:A444	R:R:F448	2.77	No	No	0	5	8
587	R:R:A499	R:R:F503	2.77	No	Yes	0	4	7
588	R:R:A500	R:R:F503	2.77	No	Yes	0	6	7
589	R:R:H186	R:R:T159	2.74	No	No	0	1	3
590	R:R:N106	R:R:N107	2.72	No	No	0	6	5
591	R:R:E34	R:R:K36	2.7	No	No	0	2	5
592	R:R:E87	R:R:K63	2.7	No	No	0	6	5
593	R:R:E73	R:R:K74	2.7	No	Yes	0	2	3
594	R:R:L55	R:R:Q79	2.66	No	Yes	0	4	7
595	R:R:N205	R:R:Q183	2.64	No	No	0	2	1
596	R:R:R247	R:R:T270	2.59	Yes	No	0	4	8
597	R:R:H469	R:R:L465	2.57	Yes	No	0	5	5
598	R:R:I22	R:R:R21	2.51	No	No	0	4	1
599	R:R:I285	R:R:R282	2.51	No	No	0	1	4
600	R:R:K572	R:R:R569	2.48	No	No	0	8	6
601	R:R:E207	R:R:H231	2.46	No	No	0	1	4
602	R:R:F590	R:R:L601	2.44	No	No	0	8	6
603	R:R:I495	R:R:W494	2.35	No	No	0	1	6
604	R:R:N431	R:R:Y432	2.33	No	No	0	5	5
605	R:R:L416	R:R:W370	2.28	No	No	0	6	9
606	R:R:E239	R:R:Y236	2.24	No	No	0	3	2
607	R:R:F448	R:R:Y414	2.06	No	Yes	0	8	7
608	R:R:G70	R:R:P95	2.03	No	No	0	1	5
609	R:R:G379	R:R:P623	2.03	No	No	0	7	9
610	R:R:A376	R:R:G412	1.95	No	No	0	8	9
611	R:R:A586	R:R:P587	1.87	No	No	0	7	9
612	R:R:G219	R:R:S218	1.86	No	No	0	6	3
613	R:R:G192	R:R:V166	1.84	No	Yes	0	5	1
614	R:R:G131	R:R:T130	1.82	No	Yes	0	5	8
615	R:R:C275	R:R:C346	1.82	No	Yes	0	9	9
616	R:R:G439	R:R:T438	1.82	No	Yes	0	9	5
617	R:R:C442	R:R:C517	1.82	No	Yes	0	9	9
618	R:R:A376	R:R:C620	1.81	No	No	0	8	7
619	R:R:A452	R:R:C410	1.81	No	No	0	8	7
620	R:R:P525	R:R:S524	1.78	No	Yes	0	4	5
621	R:R:P600	R:R:V599	1.77	No	No	0	6	5
622	R:R:G412	R:R:I377	1.76	No	Yes	0	9	5
623	R:R:G412	R:R:I411	1.76	No	Yes	0	9	7
624	R:R:G493	R:R:M492	1.75	No	No	0	8	2
625	R:R:G64	R:R:K63	1.74	No	No	0	4	5
626	R:R:A407	R:R:S456	1.71	No	No	0	8	9
627	R:R:A595	R:R:S594	1.71	No	No	0	9	8
628	R:R:G181	R:R:N180	1.7	No	Yes	0	5	9
629	R:R:A189	R:R:V213	1.7	No	Yes	0	8	8
630	R:R:G216	R:R:N191	1.7	No	Yes	0	4	5
631	R:R:A541	R:R:V457	1.7	No	No	0	9	8
632	R:R:A462	R:R:V489	1.7	No	No	0	5	5
633	R:R:A571	R:R:V556	1.7	No	No	0	8	8
634	R:R:A217	R:R:T193	1.68	No	No	0	6	5
635	R:R:A541	R:R:T461	1.68	No	No	0	9	8
636	R:R:L94	R:R:P95	1.64	No	No	0	8	5
637	R:R:L119	R:R:P120	1.64	Yes	No	0	8	8
638	R:R:N112	R:R:P113	1.63	No	No	0	5	4
639	R:R:S564	R:R:S566	1.63	No	No	0	5	5
640	R:R:S420	R:R:V421	1.62	No	No	0	4	7
641	R:R:S456	R:R:V457	1.62	No	No	0	9	8
642	R:R:A571	R:R:I552	1.62	No	Yes	0	8	8
643	R:R:C584	R:R:M585	1.62	No	No	0	9	7
644	R:R:D137	R:R:P113	1.61	No	No	0	7	4
645	R:R:A487	R:R:M490	1.61	No	Yes	0	4	7
646	R:R:A595	R:R:M520	1.61	No	No	0	9	8
647	R:R:V539	R:R:V543	1.6	No	No	0	7	4
648	R:R:S563	R:R:T568	1.6	No	No	0	5	6
649	R:R:S605	R:R:T603	1.6	No	No	0	7	7
650	R:R:G181	R:R:H158	1.59	No	No	0	5	3
651	R:R:C356	R:R:N280	1.57	Yes	No	0	9	5
652	R:R:I522	R:R:S527	1.55	Yes	No	0	6	7
653	R:R:I639	R:R:S642	1.55	No	No	0	4	5
654	R:R:I381	R:R:V385	1.54	No	No	0	3	2
655	R:R:K643	R:R:S642	1.53	No	No	0	5	5
656	R:R:L526	R:R:S524	1.5	No	Yes	0	4	5
657	R:R:K606	R:R:T603	1.5	No	No	0	6	7
658	R:R:L465	R:R:V544	1.49	No	No	0	5	4
659	R:R:L375	R:R:T378	1.47	No	No	0	6	3
660	R:R:E171	R:R:S169	1.44	No	Yes	0	6	4
661	R:R:F591	R:R:P587	1.44	No	No	0	8	9
662	R:R:E84	R:R:V85	1.43	No	No	0	4	4
663	R:R:I372	R:R:L368	1.43	No	No	0	8	6
664	R:R:I155	R:R:N156	1.42	No	No	0	5	4
665	R:R:D435	R:R:I434	1.4	No	Yes	0	4	7
666	R:R:H615	R:R:S453	1.39	No	No	0	6	8
667	R:R:H158	R:R:T159	1.37	No	No	0	3	3
668	R:R:H424	R:R:T425	1.37	No	No	0	4	9
669	R:R:N106	R:R:N129	1.36	No	No	0	6	8
670	R:R:D212	R:R:N187	1.35	No	No	0	4	4
671	R:R:D212	R:R:N211	1.35	No	No	0	4	2
672	R:R:H134	R:R:I111	1.33	No	Yes	0	3	9
673	R:R:R59	R:R:V60	1.31	No	No	0	2	4
674	R:R:R366	R:R:V367	1.31	Yes	No	0	9	5
675	R:R:F496	R:R:L537	1.22	No	No	0	5	4
676	R:R:N27	R:R:R28	1.21	No	No	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H20	8.915	6	4	7
2	R:R:F30	7.07714	7	4	5
3	R:R:I40	5.328	5	4	5
4	R:R:P41	5.6325	4	4	9
5	R:R:L44	6.6275	4	4	2
6	R:R:L51	4.3025	4	4	8
7	R:R:R52	12.9175	4	0	5
8	R:R:I61	5.8825	4	1	8
9	R:R:F66	7.665	4	1	8
10	R:R:K74	13.475	4	7	3
11	R:R:I75	9.2625	4	1	7
12	R:R:S78	5.93	4	14	5
13	R:R:Q79	7.8675	4	14	7
14	R:R:I86	5.85	4	1	8
15	R:R:D89	9.685	4	12	3
16	R:R:V90	4.595	4	1	9
17	R:R:F91	11.058	5	1	9
18	R:R:L97	8.07	4	1	8
19	R:R:I100	6.656	5	1	8
20	R:R:L108	5.03833	6	1	9
21	R:R:I111	5.028	5	1	9
22	R:R:E114	13.47	4	12	6
23	R:R:F116	9.0975	4	1	9
24	R:R:L119	3.9025	4	1	8
25	R:R:L122	3.2775	4	1	9
26	R:R:Y124	7.0175	4	7	6
27	R:R:T130	5.458	5	1	8
28	R:R:I132	7.166	5	1	7
29	R:R:L135	4.03	4	0	7
30	R:R:I141	4.494	5	1	8
31	R:R:V147	4.135	6	1	6
32	R:R:L149	5.2425	4	1	8
33	R:R:I151	4.2625	4	1	7
34	R:R:Q152	6.94	5	6	7
35	R:R:N154	8.1875	4	1	9
36	R:R:I160	5.535	4	0	6
37	R:R:R162	8.925	4	11	4
38	R:R:V166	5.91	4	11	1
39	R:R:L168	6.39	5	1	5
40	R:R:S169	4.01	4	1	4
41	R:R:L175	9.5075	4	1	7
42	R:R:W176	18.51	4	6	6
43	R:R:L177	5.36	4	1	9
44	R:R:K179	6.9225	4	6	6
45	R:R:N180	4.275	4	1	9
46	R:R:I185	4.47	4	1	7
47	R:R:C188	4.465	4	11	4
48	R:R:F190	7.41167	6	1	9
49	R:R:N191	7.3	5	11	5
50	R:R:L195	8.7625	4	1	9
51	R:R:D196	4.49	4	7	4
52	R:R:L198	6.88	4	1	7
53	R:R:N199	11.135	4	6	5
54	R:R:L206	7.846	5	1	8
55	R:R:L209	6.875	4	1	7
56	R:R:V213	5.37	4	1	8
57	R:R:F214	6.02833	6	1	9
58	R:R:P220	6.696	5	1	8
59	R:R:V221	4.1125	4	0	1
60	R:R:D224	7.605	4	6	9
61	R:R:T228	5.7025	4	1	9
62	R:R:I230	7.6425	4	1	8
63	R:R:P234	4.07	4	1	9
64	R:R:R247	4.3625	4	0	4
65	R:R:Y250	10.346	5	15	3
66	R:R:L255	5.245	4	0	6
67	R:R:F278	8.34	4	13	8
68	R:R:C346	3.61	4	13	9
69	R:R:C356	5.23	4	0	9
70	R:R:I359	8.39	4	3	8
71	R:R:M360	7.7375	4	3	7
72	R:R:R366	6.682	5	3	9
73	R:R:I369	7.12	4	3	8
74	R:R:I377	2.954	5	17	5
75	R:R:V396	4.0175	4	0	8
76	R:R:R398	10.19	4	5	8
77	R:R:D408	8.25	4	8	9
78	R:R:L409	5.27	4	17	5
79	R:R:I411	3.7575	4	0	7
80	R:R:Y414	9.44667	6	9	7
81	R:R:L415	3.7275	4	0	8
82	R:R:D422	9.7075	4	3	9
83	R:R:Y429	6.82	6	3	9
84	R:R:I434	4.205	4	0	7
85	R:R:W436	9.585	4	3	9
86	R:R:T438	3.5875	4	15	5
87	R:R:F447	8.478	5	10	8
88	R:R:F451	9.072	5	10	8
89	R:R:T464	8.314	5	2	8
90	R:R:R467	10.0575	4	2	9
91	R:R:W468	8.07167	6	2	5
92	R:R:H469	6.7625	4	2	5
93	R:R:T470	7.015	4	2	8
94	R:R:I471	7.0925	4	2	8
95	R:R:H473	6.9275	4	2	4
96	R:R:M490	6.2125	4	0	7
97	R:R:F503	8.3125	4	20	7
98	R:R:Y511	13.1075	4	9	8
99	R:R:S515	5.755	4	3	9
100	R:R:C517	4.3525	4	9	9
101	R:R:D521	6.55	4	0	8
102	R:R:I522	3.275	4	21	6
103	R:R:S524	3.1475	4	0	5
104	R:R:Y530	13.1275	4	20	7
105	R:R:I545	8.326	5	2	8
106	R:R:C548	4.41	4	2	6
107	R:R:Y549	14.674	5	2	9
108	R:R:I552	5.6525	4	2	8
109	R:R:M574	7.3525	4	2	9
110	R:R:K608	3.956	5	3	9
111	R:R:I609	7.91	4	16	8
112	R:R:N618	10.2225	4	8	9
113	R:R:L625	5.26	4	8	8
114	R:R:Y626	15.4225	4	5	9
115	R:R:F629	11.525	4	8	6
116	R:R:F633	7.76667	6	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I100	R:R:L125	13.1083	5.71	Yes	No	0	8	8
2	R:R:L125	R:R:L149	13.3204	4.15	No	Yes	0	8	8
3	R:R:L149	R:R:L175	19.1018	5.54	Yes	Yes	1	8	7
4	R:R:G219	R:R:P220	30.7484	4.06	No	Yes	0	6	8
5	R:R:G219	R:R:N240	30.0759	3.39	No	No	0	6	4
6	R:R:N240	R:R:V221	29.8507	5.91	No	Yes	0	4	1
7	R:R:D196	R:R:V221	22.0998	2.92	Yes	Yes	0	4	1
8	R:R:D196	R:R:I174	21.3713	5.6	Yes	No	7	4	5
9	R:R:I174	R:R:L148	21.2454	7.14	No	No	7	5	5
10	R:R:L148	R:R:Y124	14.0921	10.55	No	Yes	7	5	6
11	R:R:H98	R:R:Q123	12.82	3.71	No	No	7	4	5
12	R:R:H98	R:R:K74	12.311	32.75	No	Yes	7	4	3
13	R:R:K74	R:R:R52	12.4458	4.95	Yes	Yes	0	3	5
14	R:R:G131	R:R:T130	29.1049	1.82	No	Yes	0	5	8
15	R:R:G131	R:R:N156	27.8883	6.79	No	No	0	5	4
16	R:R:K133	R:R:N156	25.4554	12.59	No	No	0	4	4
17	R:R:K133	R:R:L109	24.2392	9.87	No	No	0	4	5
18	R:R:L109	R:R:Y110	23.0235	3.52	No	No	0	5	1
19	R:R:V85	R:R:Y110	21.8103	5.05	No	No	0	4	1
20	R:R:V60	R:R:V85	14.5314	8.02	No	No	0	4	4
21	R:R:N154	R:R:T130	26.1102	5.85	Yes	Yes	1	9	8
22	R:R:L135	R:R:P136	17.8556	3.28	Yes	No	0	7	9
23	R:R:I151	R:R:N154	19.0583	2.83	Yes	Yes	1	7	9
24	R:R:I160	R:R:L135	35.357	2.85	Yes	Yes	0	6	7
25	R:R:I160	R:R:I185	36.2851	7.36	Yes	Yes	0	6	7
26	R:R:F190	R:R:L175	16.1925	4.87	Yes	Yes	1	9	7
27	R:R:F190	R:R:F214	23.6282	3.22	Yes	Yes	1	9	9
28	R:R:F214	R:R:G237	14.926	3.01	Yes	No	0	9	8
29	R:R:E239	R:R:G237	14.6774	4.91	No	No	0	3	8
30	R:R:E239	R:R:Y236	14.435	2.24	No	No	0	3	2
31	R:R:S235	R:R:Y236	13.4072	10.17	No	No	18	4	2
32	R:R:N211	R:R:S235	13.2469	5.96	No	No	0	2	4
33	R:R:D212	R:R:N211	13.0091	1.35	No	No	0	4	2
34	R:R:D212	R:R:N187	12.7718	1.35	No	No	0	4	4
35	R:R:H274	R:R:L255	100	3.86	No	Yes	0	9	6
36	R:R:L252	R:R:L255	58.1443	9.69	No	Yes	0	8	6
37	R:R:L233	R:R:L252	42.279	4.15	No	No	0	8	8
38	R:R:L233	R:R:P234	84.3757	4.93	No	Yes	0	8	9
39	R:R:L209	R:R:P234	24.5528	4.93	Yes	Yes	1	7	9
40	R:R:I185	R:R:L209	24.1173	4.28	Yes	Yes	1	7	7
41	R:R:L255	R:R:P256	42.1667	3.28	Yes	No	0	6	7
42	R:R:L233	R:R:P256	42.1812	6.57	No	No	0	8	7
43	R:R:L252	R:R:T249	16.122	4.42	No	No	0	8	7
44	R:R:T228	R:R:T249	15.837	4.71	Yes	No	0	9	7
45	R:R:L206	R:R:T228	15.7539	4.42	Yes	Yes	1	8	9
46	R:R:I185	R:R:L206	12.2048	2.85	Yes	Yes	1	7	8
47	R:R:F214	R:R:P234	60.3642	2.89	Yes	Yes	1	9	9
48	R:R:H274	R:R:I434	90.4677	9.28	No	Yes	0	9	7
49	R:R:A433	R:R:Y429	92.5652	4	No	Yes	0	9	9
50	R:R:A433	R:R:S273	92.7407	3.42	No	No	0	9	8
51	R:R:I434	R:R:S273	92.9158	3.1	Yes	No	0	7	8
52	R:R:K608	R:R:V604	11.2535	3.04	Yes	No	0	9	8
53	R:R:I359	R:R:K608	17.4372	2.91	Yes	Yes	3	8	9
54	R:R:I359	R:R:Y429	69.6068	14.51	Yes	Yes	3	8	9
55	R:R:K608	R:R:S515	14.3999	6.12	Yes	Yes	3	9	9
56	R:R:S515	R:R:Y429	14.9189	3.82	Yes	Yes	3	9	9
57	R:R:D422	R:R:I359	58.1361	8.4	Yes	Yes	3	9	8
58	R:R:D422	R:R:M360	56.3003	9.7	Yes	Yes	3	9	7
59	R:R:I369	R:R:M360	55.9649	10.2	Yes	Yes	3	8	7
60	R:R:I369	R:R:L415	55.5336	4.28	Yes	Yes	0	8	8
61	R:R:L625	R:R:T580	11.2537	7.37	Yes	No	8	8	8
62	R:R:N618	R:R:T580	11.55	7.31	Yes	No	8	9	8
63	R:R:N618	R:R:N622	13.7456	10.9	Yes	No	8	9	9
64	R:R:D408	R:R:N622	12.912	9.42	Yes	No	8	9	9
65	R:R:D408	R:R:S619	44.9817	7.36	Yes	No	0	9	9
66	R:R:I411	R:R:S619	45.2342	3.1	Yes	No	0	7	9
67	R:R:H615	R:R:I411	46.99	5.3	No	Yes	0	6	7
68	R:R:H615	R:R:P616	47.4756	6.1	No	No	0	6	9
69	R:R:L415	R:R:P616	47.7232	3.28	Yes	No	0	8	9
70	R:R:D408	R:R:L404	32.5738	8.14	Yes	No	8	9	8
71	R:R:L404	R:R:T459	33.4387	2.95	No	No	0	8	8
72	R:R:N403	R:R:T459	33.1602	2.92	No	No	0	8	8
73	R:R:M490	R:R:N403	32.6019	15.43	Yes	No	0	7	8
74	R:R:L400	R:R:M490	31.7608	2.83	No	Yes	0	8	7
75	R:R:I463	R:R:L400	28.518	15.7	No	No	0	9	8
76	R:R:I516	R:R:K608	20.3648	4.36	No	Yes	0	8	9
77	R:R:I516	R:R:L518	19.4608	14.27	No	No	0	8	8
78	R:R:L518	R:R:P519	17.7127	3.28	No	No	0	8	9
79	R:R:I463	R:R:M574	28.233	5.83	No	Yes	0	9	9
80	R:R:M574	R:R:T464	12.0206	3.01	Yes	Yes	2	9	8
81	R:R:M574	R:R:Y549	12.0206	14.37	Yes	Yes	2	9	9
82	R:R:C548	R:R:W468	13.0477	3.92	Yes	Yes	2	6	5
83	R:R:F214	R:R:P220	26.7746	13	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8I2H

PDB Summary
PDB	8I2H
Class	A
SubFamily	Protein
Type	Glycoprotein hormone
SubType	FSH
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	6
Date	2023-03-22
D.O.I.	10.1038/s41467-023-36170-3

Net Summary
I_min	2.83
Number of Linked Nodes	546
Number of Links	676
Number of Hubs	116
Number of Links mediated by Hubs	387
Number of Communities	21
Number of Nodes involved in Communities	188
Number of Links involved in Communities	273

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	557574
Length Of Smallest Path	3
Average Path Length	29.141
Length of Longest Path	54
Minimum Path Strength	1.35
Average Path Strength	6.24511
Maximum Path Strength	26.37
Minimum Path Correlation	0.7
Average Path Correlation	0.9741
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	45.3766
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0037
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P23945
Sequence	>8I2H_Chain_R H R I C H C S N R V F L C Q E S K V T E I P S D L P R N A I E L R F V L T K L R V I Q K G A F S G F G D L E K I E I S Q N D V L E V I E A D V F S N L P K L H E I R I E K A N N L L Y I N P E A F Q N L P N L Q Y L L I S N T G I K H L P D V H K I H S L Q K V L L D I Q D N I N I H T I E R N S F V G L S F E S V I L W L N K N G I Q E I H N C A F N G T Q L D E L N L S D N N N L E E L P N D V F H G A S G P V I L D I S R T R I H S L P S Y G L E N L K K L R A R S T Y N L K K L P T L E K L V A L M E A S L T Y P S H C C A F A N W R R Q I S E V T C S P K P D A F N P C E D I M G Y N I L R V L I W F I S I L A I T G N I I V L V I L T T S Q Y K L T V P R F L M C N L A F A D L C I G I Y L L L I A S V D I H T K S Q Y H N Y A I D W Q T G A G C D A A G F F T V F A S E L S V Y T L T A I T L E R W H T I T H A M Q L D C K V Q L R H A A S V M V M G W I F A F A A A L F P I F G I S S Y M K V S I C L P M D I D S P L S Q L Y V M S L L V L N V L A F V V I C G C Y I H I Y L T V R N P N I V S S S S D T R I A K R M A M L I F T D F L C M A P I S F F A I S A S L K V P L I T V S K A K I L L V L F H P I N S C A N P F L Y A I F T K N F R R D F F I L L S K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I2G	A	Protein	Glycoprotein hormone	FSH	Homo sapiens	Glycoprotein hormones alpha chain	Compound 716340	Gs/&β;1/&γ;2	2.8	2023-03-29	10.1038/s41467-023-36170-3
	8I2H	A	Protein	Glycoprotein hormone	FSH	Homo sapiens	-	-	-	6	2023-03-22	10.1038/s41467-023-36170-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8I2H.zip

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