psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C25	R:R:H20	4.42	No	Yes	0	8	7
2	R:R:D43	R:R:H20	18.91	No	Yes	0	5	7
3	R:R:H20	R:R:L44	2.57	Yes	Yes	1	7	2
4	R:R:H20	R:R:P45	9.15	Yes	No	1	7	2
5	R:R:I22	R:R:R21	11.27	Yes	No	0	4	1
6	R:R:C23	R:R:I22	1.64	Yes	Yes	1	8	4
7	R:R:C32	R:R:I22	4.91	Yes	Yes	1	9	4
8	R:R:I22	R:R:K36	2.91	Yes	No	0	4	5
9	R:R:I22	R:R:V37	3.07	Yes	Yes	1	4	6
10	R:R:I22	R:R:P41	3.39	Yes	Yes	1	4	9
11	R:R:C23	R:R:C25	1.82	Yes	No	0	8	8
12	R:R:C23	R:R:F30	12.57	Yes	Yes	1	8	5
13	R:R:C23	R:R:C32	5.46	Yes	Yes	1	8	9
14	R:R:H24	R:R:S26	4.18	No	No	0	2	4
15	R:R:N27	R:R:R28	4.82	No	No	0	1	1
16	R:R:N47	R:R:R28	3.62	No	No	0	5	1
17	R:R:E50	R:R:V29	7.13	No	No	0	4	5
18	R:R:C32	R:R:F30	6.98	Yes	Yes	1	9	5
19	R:R:F30	R:R:P41	4.33	Yes	Yes	1	5	9
20	R:R:F30	R:R:L44	20.7	Yes	Yes	1	5	2
21	R:R:F30	R:R:L51	7.31	Yes	Yes	1	5	8
22	R:R:F30	R:R:F53	7.5	Yes	Yes	1	5	6
23	R:R:L31	R:R:R52	19.44	No	No	0	4	5
24	R:R:C32	R:R:V37	6.83	Yes	Yes	1	9	6
25	R:R:C32	R:R:P41	1.88	Yes	Yes	1	9	9
26	R:R:C32	R:R:F53	8.38	Yes	Yes	1	9	6
27	R:R:E34	R:R:Q33	22.94	No	No	0	2	4
28	R:R:E34	R:R:K36	4.05	No	No	0	2	5
29	R:R:K57	R:R:S35	6.12	No	No	0	3	3
30	R:R:F53	R:R:V37	7.87	Yes	Yes	1	6	6
31	R:R:T56	R:R:V37	7.93	No	Yes	1	6	6
32	R:R:I40	R:R:P41	3.39	No	Yes	1	5	9
33	R:R:I40	R:R:I61	2.94	No	Yes	1	5	8
34	R:R:A65	R:R:I40	6.5	No	No	1	5	5
35	R:R:D43	R:R:P41	1.61	No	Yes	0	5	9
36	R:R:L44	R:R:P45	8.21	Yes	No	1	2	2
37	R:R:A48	R:R:L44	1.58	No	Yes	1	3	2
38	R:R:F69	R:R:L44	9.74	Yes	Yes	1	6	2
39	R:R:N47	R:R:P45	4.89	No	No	0	5	2
40	R:R:G70	R:R:R46	3	No	No	0	1	1
41	R:R:A48	R:R:F69	2.77	No	Yes	1	3	6
42	R:R:A48	R:R:L72	1.58	No	Yes	1	3	7
43	R:R:E73	R:R:I49	15.03	No	No	0	2	3
44	R:R:E50	R:R:K74	18.9	No	No	0	4	3
45	R:R:F53	R:R:L51	2.44	Yes	Yes	1	6	8
46	R:R:F66	R:R:L51	14.61	Yes	Yes	1	8	8
47	R:R:L51	R:R:L72	5.54	Yes	Yes	1	8	7
48	R:R:I75	R:R:L51	11.42	Yes	Yes	1	7	8
49	R:R:R52	R:R:V54	7.85	No	No	0	5	2
50	R:R:E76	R:R:R52	2.33	Yes	No	0	5	5
51	R:R:F53	R:R:T56	6.49	Yes	No	1	6	6
52	R:R:F53	R:R:I77	5.02	Yes	No	0	6	8
53	R:R:S78	R:R:V54	4.85	No	No	5	5	2
54	R:R:Q79	R:R:V54	7.16	No	No	5	7	2
55	R:R:L55	R:R:Q79	6.65	No	No	0	4	7
56	R:R:N80	R:R:T56	7.31	No	No	0	7	6
57	R:R:K57	R:R:V82	3.04	No	No	0	3	5
58	R:R:L58	R:R:L83	2.77	No	No	0	3	8
59	R:R:R59	R:R:V82	5.23	No	No	0	2	5
60	R:R:V60	R:R:V85	4.81	No	No	0	4	4
61	R:R:E87	R:R:V60	2.85	No	No	0	6	4
62	R:R:A65	R:R:I61	3.25	No	Yes	1	5	8
63	R:R:I61	R:R:I86	4.42	Yes	Yes	1	8	8
64	R:R:I61	R:R:V90	6.14	Yes	No	1	8	9
65	R:R:G64	R:R:K63	6.97	No	No	0	4	5
66	R:R:E87	R:R:K63	4.05	No	No	0	6	5
67	R:R:D89	R:R:K63	6.91	Yes	No	0	3	5
68	R:R:G64	R:R:S67	3.71	No	No	0	4	1
69	R:R:F66	R:R:F69	20.36	Yes	Yes	1	8	6
70	R:R:F66	R:R:L72	13.4	Yes	Yes	1	8	7
71	R:R:F66	R:R:I75	3.77	Yes	Yes	1	8	7
72	R:R:F66	R:R:F91	3.22	Yes	Yes	1	8	9
73	R:R:F66	R:R:L94	6.09	Yes	Yes	1	8	8
74	R:R:F69	R:R:L72	7.31	Yes	Yes	1	6	7
75	R:R:G70	R:R:P95	2.03	No	No	0	1	5
76	R:R:D71	R:R:K96	2.77	No	No	0	4	6
77	R:R:E73	R:R:H98	3.69	No	Yes	0	2	4
78	R:R:E99	R:R:K74	12.15	No	No	0	6	3
79	R:R:F91	R:R:I75	8.79	Yes	Yes	1	9	7
80	R:R:I75	R:R:L97	2.85	Yes	Yes	1	7	8
81	R:R:I100	R:R:I75	2.94	Yes	Yes	1	8	7
82	R:R:E76	R:R:S78	5.75	Yes	No	5	5	5
83	R:R:E76	R:R:R101	6.98	Yes	Yes	5	5	5
84	R:R:E103	R:R:E76	10.15	No	Yes	5	5	5
85	R:R:I77	R:R:N80	7.08	No	No	0	8	7
86	R:R:I102	R:R:I77	2.94	No	No	0	8	8
87	R:R:Q79	R:R:S78	2.89	No	No	5	7	5
88	R:R:L83	R:R:N80	5.49	No	No	0	8	7
89	R:R:D81	R:R:V82	8.76	No	No	0	7	5
90	R:R:L108	R:R:L83	5.54	Yes	No	0	9	8
91	R:R:E84	R:R:V85	7.13	No	No	0	4	4
92	R:R:E84	R:R:N107	7.89	No	No	0	4	5
93	R:R:V85	R:R:Y110	5.05	No	No	0	4	1
94	R:R:I86	R:R:V90	7.68	Yes	No	1	8	9
95	R:R:I86	R:R:L108	2.85	Yes	Yes	1	8	9
96	R:R:I111	R:R:I86	4.42	Yes	Yes	1	9	8
97	R:R:A115	R:R:I86	3.25	Yes	Yes	1	8	8
98	R:R:A88	R:R:D89	3.09	No	Yes	9	5	3
99	R:R:A88	R:R:N112	4.69	No	No	0	5	5
100	R:R:A88	R:R:E114	3.02	No	No	9	5	6
101	R:R:D89	R:R:S92	2.94	Yes	No	0	3	4
102	R:R:D89	R:R:E114	5.2	Yes	No	9	3	6
103	R:R:D89	R:R:Q117	3.92	Yes	No	9	3	5
104	R:R:F91	R:R:V90	6.55	Yes	No	1	9	9
105	R:R:F91	R:R:L94	3.65	Yes	Yes	1	9	8
106	R:R:F91	R:R:I100	8.79	Yes	Yes	1	9	8
107	R:R:F116	R:R:F91	11.79	Yes	Yes	1	9	9
108	R:R:N118	R:R:N93	9.54	No	No	0	6	6
109	R:R:L94	R:R:P95	1.64	Yes	No	0	8	5
110	R:R:L94	R:R:L97	12.46	Yes	Yes	1	8	8
111	R:R:H98	R:R:K96	2.62	Yes	No	0	4	6
112	R:R:L119	R:R:L97	2.77	Yes	Yes	1	8	8
113	R:R:L122	R:R:L97	2.77	Yes	Yes	1	9	8
114	R:R:H98	R:R:N121	10.2	Yes	No	0	4	4
115	R:R:H98	R:R:Q123	9.89	Yes	No	0	4	5
116	R:R:E99	R:R:Q123	3.82	No	No	0	6	5
117	R:R:E99	R:R:Y124	6.73	No	Yes	0	6	6
118	R:R:F116	R:R:I100	2.51	Yes	Yes	1	9	8
119	R:R:I100	R:R:L125	9.99	Yes	No	0	8	8
120	R:R:E103	R:R:R101	6.98	No	Yes	5	5	5
121	R:R:R101	R:R:Y124	2.06	Yes	Yes	0	5	6
122	R:R:L126	R:R:R101	7.29	No	Yes	5	7	5
123	R:R:A105	R:R:I102	3.25	No	No	0	8	8
124	R:R:I102	R:R:I127	2.94	No	Yes	0	8	9
125	R:R:E103	R:R:L126	6.63	No	No	5	5	7
126	R:R:K104	R:R:N129	9.79	No	No	0	6	8
127	R:R:A105	R:R:L108	3.15	No	Yes	1	8	9
128	R:R:A105	R:R:T130	1.68	No	Yes	1	8	8
129	R:R:N106	R:R:N107	2.72	No	No	0	6	5
130	R:R:L108	R:R:T130	5.9	Yes	Yes	1	9	8
131	R:R:I132	R:R:L108	4.28	No	Yes	0	7	9
132	R:R:K133	R:R:L109	5.64	No	No	0	4	5
133	R:R:A115	R:R:I111	1.62	Yes	Yes	1	8	9
134	R:R:F116	R:R:I111	6.28	Yes	Yes	1	9	9
135	R:R:I111	R:R:I132	5.89	Yes	No	0	9	7
136	R:R:I111	R:R:P136	8.47	Yes	Yes	1	9	9
137	R:R:N112	R:R:P113	4.89	No	No	0	5	4
138	R:R:D137	R:R:P113	6.44	No	No	0	7	4
139	R:R:E114	R:R:Q117	12.74	No	No	9	6	5
140	R:R:A115	R:R:F116	8.32	Yes	Yes	1	8	9
141	R:R:F116	R:R:P136	4.33	Yes	Yes	1	9	9
142	R:R:K140	R:R:Q117	24.41	No	No	0	5	5
143	R:R:K140	R:R:N118	2.8	No	No	0	5	6
144	R:R:L119	R:R:P120	1.64	Yes	No	0	8	8
145	R:R:L119	R:R:L122	8.3	Yes	Yes	1	8	9
146	R:R:I141	R:R:L119	12.85	Yes	Yes	1	8	8
147	R:R:N121	R:R:P120	1.63	No	No	0	4	8
148	R:R:L144	R:R:P120	3.28	No	No	0	6	8
149	R:R:I141	R:R:L122	7.14	Yes	Yes	1	8	9
150	R:R:L122	R:R:S143	4.5	Yes	Yes	1	9	8
151	R:R:L122	R:R:V147	7.45	Yes	Yes	1	9	6
152	R:R:K146	R:R:Q123	4.07	No	No	0	6	5
153	R:R:L148	R:R:Y124	10.55	No	Yes	0	5	6
154	R:R:D150	R:R:Y124	5.75	Yes	Yes	0	7	6
155	R:R:I127	R:R:L125	2.85	Yes	No	0	9	8
156	R:R:L125	R:R:L149	2.77	No	No	0	8	8
157	R:R:D150	R:R:L126	9.5	Yes	No	0	7	7
158	R:R:I127	R:R:T130	10.64	Yes	Yes	1	9	8
159	R:R:I127	R:R:P136	1.69	Yes	Yes	1	9	9
160	R:R:I127	R:R:I151	2.94	Yes	Yes	1	9	7
161	R:R:I127	R:R:N154	2.83	Yes	Yes	1	9	9
162	R:R:Q152	R:R:S128	5.78	Yes	No	0	7	7
163	R:R:D153	R:R:N129	5.39	No	No	0	6	8
164	R:R:G131	R:R:T130	1.82	No	Yes	0	5	8
165	R:R:N154	R:R:T130	2.92	Yes	Yes	1	9	8
166	R:R:G131	R:R:N156	5.09	No	No	0	5	4
167	R:R:I132	R:R:I157	2.94	No	Yes	0	7	7
168	R:R:H134	R:R:K133	11.79	No	No	0	3	4
169	R:R:L135	R:R:P136	8.21	No	Yes	0	7	9
170	R:R:I151	R:R:L135	4.28	Yes	No	0	7	7
171	R:R:F165	R:R:L135	2.44	Yes	No	0	7	7
172	R:R:I141	R:R:V138	3.07	Yes	No	1	8	7
173	R:R:L168	R:R:V138	7.45	Yes	No	1	5	7
174	R:R:H139	R:R:V166	9.69	No	Yes	7	6	1
175	R:R:G167	R:R:H139	4.77	No	No	7	5	6
176	R:R:I141	R:R:S143	6.19	Yes	Yes	1	8	8
177	R:R:I141	R:R:L168	4.28	Yes	Yes	1	8	5
178	R:R:H142	R:R:L144	2.57	No	No	0	4	6
179	R:R:F170	R:R:H142	5.66	No	No	0	3	4
180	R:R:S143	R:R:V147	4.85	Yes	Yes	1	8	6
181	R:R:S143	R:R:S169	4.89	Yes	Yes	1	8	4
182	R:R:L168	R:R:V147	7.45	Yes	Yes	1	5	6
183	R:R:S169	R:R:V147	8.08	Yes	Yes	1	4	6
184	R:R:V147	R:R:V173	4.81	Yes	No	1	6	4
185	R:R:I174	R:R:L148	15.7	Yes	No	0	5	5
186	R:R:I151	R:R:L149	4.28	Yes	No	0	7	8
187	R:R:F165	R:R:L149	3.65	Yes	No	0	7	8
188	R:R:D150	R:R:Q152	7.83	Yes	Yes	0	7	7
189	R:R:D150	R:R:W176	7.82	Yes	No	0	7	6
190	R:R:I151	R:R:N154	12.74	Yes	Yes	1	7	9
191	R:R:I151	R:R:L177	8.56	Yes	Yes	1	7	9
192	R:R:I151	R:R:N180	9.91	Yes	Yes	1	7	9
193	R:R:N178	R:R:Q152	6.6	No	Yes	10	5	7
194	R:R:K179	R:R:Q152	2.71	No	Yes	10	6	7
195	R:R:D153	R:R:K179	8.3	No	No	0	6	6
196	R:R:I157	R:R:N154	5.66	Yes	Yes	1	7	9
197	R:R:N154	R:R:N180	10.9	Yes	Yes	1	9	9
198	R:R:I155	R:R:N156	2.83	No	No	0	5	4
199	R:R:I157	R:R:N180	4.25	Yes	Yes	1	7	9
200	R:R:I157	R:R:I182	2.94	Yes	Yes	1	7	8
201	R:R:H186	R:R:T159	4.11	No	No	0	1	3
202	R:R:I160	R:R:S164	6.19	Yes	No	1	6	6
203	R:R:I160	R:R:I182	2.94	Yes	Yes	1	6	8
204	R:R:I160	R:R:I185	5.89	Yes	Yes	1	6	7
205	R:R:A189	R:R:I160	4.87	Yes	Yes	1	8	6
206	R:R:F190	R:R:I160	3.77	Yes	Yes	1	9	6
207	R:R:N163	R:R:R162	20.49	Yes	No	0	7	4
208	R:R:N163	R:R:V166	2.96	Yes	Yes	7	7	1
209	R:R:N163	R:R:N191	12.26	Yes	Yes	7	7	5
210	R:R:F165	R:R:S164	3.96	Yes	No	0	7	6
211	R:R:A189	R:R:S164	1.71	Yes	No	1	8	6
212	R:R:F165	R:R:L175	10.96	Yes	No	0	7	7
213	R:R:F165	R:R:F190	4.29	Yes	Yes	0	7	9
214	R:R:F165	R:R:T193	2.59	Yes	No	0	7	5
215	R:R:G167	R:R:V166	1.84	No	Yes	7	5	1
216	R:R:G192	R:R:V166	1.84	No	Yes	0	5	1
217	R:R:L168	R:R:S169	6.01	Yes	Yes	1	5	4
218	R:R:L168	R:R:V173	5.96	Yes	No	1	5	4
219	R:R:S169	R:R:V173	3.23	Yes	No	1	4	4
220	R:R:E171	R:R:F170	3.5	No	No	0	6	3
221	R:R:Q194	R:R:S172	2.89	No	No	0	5	5
222	R:R:I174	R:R:W176	8.22	Yes	No	0	5	6
223	R:R:D196	R:R:I174	4.2	No	Yes	4	4	5
224	R:R:E197	R:R:I174	6.83	Yes	Yes	4	5	5
225	R:R:L175	R:R:L195	6.92	No	Yes	0	7	9
226	R:R:L175	R:R:L198	5.54	No	Yes	0	7	7
227	R:R:N199	R:R:W176	21.47	No	No	0	5	6
228	R:R:L177	R:R:N180	10.98	Yes	Yes	1	9	9
229	R:R:I182	R:R:L177	2.85	Yes	Yes	1	8	9
230	R:R:L177	R:R:L200	5.54	Yes	No	0	9	9
231	R:R:K179	R:R:N178	5.6	No	No	10	6	5
232	R:R:D202	R:R:N178	4.04	No	No	0	5	5
233	R:R:G181	R:R:N180	1.7	No	Yes	0	5	9
234	R:R:I182	R:R:N180	2.83	Yes	Yes	1	8	9
235	R:R:G181	R:R:N203	1.7	No	Yes	0	5	9
236	R:R:I182	R:R:N203	7.08	Yes	Yes	0	8	9
237	R:R:E184	R:R:Q183	15.29	No	No	11	4	1
238	R:R:N205	R:R:Q183	6.6	No	No	0	2	1
239	R:R:E207	R:R:Q183	12.74	No	No	11	1	1
240	R:R:E184	R:R:E207	6.34	No	No	11	4	1
241	R:R:A189	R:R:I185	3.25	Yes	Yes	1	8	7
242	R:R:F190	R:R:I185	3.77	Yes	Yes	1	9	7
243	R:R:I185	R:R:L209	2.85	Yes	Yes	1	7	7
244	R:R:I185	R:R:P210	8.47	Yes	Yes	1	7	6
245	R:R:I185	R:R:V213	6.14	Yes	Yes	1	7	8
246	R:R:C188	R:R:N187	6.3	No	No	0	4	4
247	R:R:D212	R:R:N187	12.12	No	No	0	4	4
248	R:R:A189	R:R:F190	8.32	Yes	Yes	1	8	9
249	R:R:A189	R:R:V213	1.7	Yes	Yes	1	8	8
250	R:R:F190	R:R:L195	7.31	Yes	Yes	1	9	9
251	R:R:F190	R:R:V213	3.93	Yes	Yes	1	9	8
252	R:R:G192	R:R:N191	5.09	No	Yes	0	5	5
253	R:R:G216	R:R:N191	5.09	No	Yes	0	4	5
254	R:R:L195	R:R:T193	7.37	Yes	No	0	9	5
255	R:R:Q194	R:R:S218	7.22	No	No	0	5	3
256	R:R:F214	R:R:L195	2.44	Yes	Yes	1	9	9
257	R:R:A217	R:R:L195	3.15	No	Yes	1	6	9
258	R:R:L195	R:R:P220	8.21	Yes	Yes	1	9	8
259	R:R:D196	R:R:E197	5.2	No	Yes	4	4	5
260	R:R:E197	R:R:N199	6.57	Yes	No	0	5	5
261	R:R:E197	R:R:I222	21.86	Yes	Yes	4	5	3
262	R:R:L198	R:R:L200	12.46	Yes	No	0	7	9
263	R:R:L198	R:R:P220	3.28	Yes	Yes	1	7	8
264	R:R:L198	R:R:L223	5.54	Yes	Yes	1	7	8
265	R:R:D224	R:R:N199	12.12	Yes	No	0	9	5
266	R:R:L200	R:R:N203	2.75	No	Yes	0	9	9
267	R:R:S201	R:R:S226	4.89	No	No	0	7	8
268	R:R:D202	R:R:R227	5.96	No	No	0	5	7
269	R:R:L206	R:R:N203	6.87	No	Yes	0	8	9
270	R:R:N204	R:R:N205	12.26	No	No	0	1	2
271	R:R:L206	R:R:L209	6.92	No	Yes	0	8	7
272	R:R:L206	R:R:T228	5.9	No	Yes	0	8	9
273	R:R:E207	R:R:R229	4.65	No	No	0	1	4
274	R:R:E208	R:R:P210	3.14	No	Yes	0	1	6
275	R:R:L209	R:R:P210	1.64	Yes	Yes	1	7	6
276	R:R:I230	R:R:L209	7.14	No	Yes	0	8	7
277	R:R:L209	R:R:P234	4.93	Yes	No	0	7	9
278	R:R:D212	R:R:P210	3.22	No	Yes	0	4	6
279	R:R:P210	R:R:V213	3.53	Yes	Yes	1	6	8
280	R:R:D212	R:R:N211	6.73	No	No	0	4	2
281	R:R:N211	R:R:S235	2.98	No	No	0	2	4
282	R:R:P234	R:R:V213	3.53	No	Yes	0	9	8
283	R:R:A217	R:R:F214	5.55	No	Yes	1	6	9
284	R:R:F214	R:R:G219	3.01	Yes	No	1	9	6
285	R:R:F214	R:R:P220	4.33	Yes	Yes	1	9	8
286	R:R:F214	R:R:G237	7.53	Yes	No	0	9	8
287	R:R:G216	R:R:H215	1.59	No	No	0	4	2
288	R:R:G219	R:R:P220	4.06	No	Yes	1	6	8
289	R:R:G219	R:R:N240	3.39	No	No	0	6	4
290	R:R:L223	R:R:P220	1.64	Yes	Yes	1	8	8
291	R:R:I222	R:R:V221	4.61	Yes	No	4	3	1
292	R:R:K242	R:R:V221	13.66	No	No	4	6	1
293	R:R:K243	R:R:V221	3.04	Yes	No	4	5	1
294	R:R:D224	R:R:I222	7	Yes	Yes	4	9	3
295	R:R:I222	R:R:K243	7.27	Yes	Yes	4	3	5
296	R:R:I222	R:R:R245	3.76	Yes	No	4	3	4
297	R:R:L223	R:R:L241	6.92	Yes	No	0	8	7
298	R:R:L223	R:R:L244	4.15	Yes	No	0	8	9
299	R:R:D224	R:R:R245	10.72	Yes	No	4	9	4
300	R:R:I225	R:R:T228	12.16	No	Yes	0	8	9
301	R:R:A246	R:R:I225	1.62	Yes	No	0	8	8
302	R:R:R247	R:R:S226	2.64	No	No	0	4	8
303	R:R:R227	R:R:S248	5.27	No	No	0	7	7
304	R:R:I230	R:R:T228	7.6	No	Yes	0	8	9
305	R:R:T228	R:R:T249	4.71	Yes	No	0	9	7
306	R:R:N251	R:R:R229	9.64	No	No	0	5	4
307	R:R:I230	R:R:L252	11.42	No	Yes	0	8	8
308	R:R:H231	R:R:N251	10.2	No	No	0	4	5
309	R:R:H231	R:R:K253	10.48	No	No	0	4	6
310	R:R:L233	R:R:P234	1.64	Yes	No	0	8	9
311	R:R:L233	R:R:L238	2.77	Yes	Yes	6	8	8
312	R:R:L233	R:R:L252	4.15	Yes	Yes	6	8	8
313	R:R:L233	R:R:L255	4.15	Yes	Yes	6	8	6
314	R:R:L233	R:R:P256	9.85	Yes	No	6	8	7
315	R:R:E239	R:R:Y236	5.61	No	No	0	3	2
316	R:R:L238	R:R:L241	6.92	Yes	No	0	8	7
317	R:R:L238	R:R:P256	1.64	Yes	No	6	8	7
318	R:R:L238	R:R:L261	4.15	Yes	No	0	8	7
319	R:R:K242	R:R:K243	11.49	No	Yes	4	6	5
320	R:R:K242	R:R:M265	4.32	No	No	0	6	5
321	R:R:R245	R:R:S268	5.27	No	No	0	4	5
322	R:R:A246	R:R:T249	3.36	Yes	No	6	8	7
323	R:R:A246	R:R:L252	1.58	Yes	Yes	6	8	8
324	R:R:A246	R:R:L269	1.58	Yes	No	0	8	7
325	R:R:L252	R:R:T249	13.27	Yes	No	6	8	7
326	R:R:T270	R:R:Y250	4.99	No	No	12	8	3
327	R:R:Y250	R:R:Y271	3.97	No	No	12	3	9
328	R:R:M512	R:R:Y250	3.59	No	No	0	5	3
329	R:R:L255	R:R:P256	3.28	Yes	No	6	6	7
330	R:R:L255	R:R:L269	5.54	Yes	No	0	6	7
331	R:R:H274	R:R:L255	5.14	No	Yes	0	9	6
332	R:R:E259	R:R:T257	7.06	No	No	0	4	4
333	R:R:T257	R:R:W281	2.43	No	Yes	0	4	5
334	R:R:F278	R:R:L258	10.96	No	No	8	8	6
335	R:R:L258	R:R:W281	9.11	No	Yes	8	6	5
336	R:R:L261	R:R:L264	6.92	No	No	0	7	6
337	R:R:A267	R:R:L264	1.58	No	No	0	8	6
338	R:R:E266	R:R:T345	7.06	No	No	0	4	3
339	R:R:A267	R:R:C346	3.61	No	Yes	0	8	9
340	R:R:T270	R:R:Y271	4.99	No	No	12	8	9
341	R:R:P272	R:R:P348	7.79	No	No	0	7	9
342	R:R:N354	R:R:P272	8.15	Yes	No	0	8	7
343	R:R:H430	R:R:S273	2.79	Yes	No	2	7	8
344	R:R:A433	R:R:S273	3.42	No	No	2	9	8
345	R:R:Q437	R:R:S273	4.33	Yes	No	2	9	8
346	R:R:C275	R:R:C346	3.64	No	Yes	0	9	9
347	R:R:C275	R:R:P350	7.53	No	No	0	9	8
348	R:R:C276	R:R:P350	7.53	No	No	0	9	8
349	R:R:C276	R:R:C356	7.28	No	No	2	9	9
350	R:R:C276	R:R:H430	10.32	No	Yes	2	9	7
351	R:R:A277	R:R:H430	2.93	No	Yes	0	8	7
352	R:R:F278	R:R:W281	3.01	No	Yes	8	8	5
353	R:R:F278	R:R:R282	10.69	No	No	8	8	4
354	R:R:H430	R:R:N280	3.83	Yes	No	0	7	5
355	R:R:Q284	R:R:W281	6.57	No	Yes	0	3	5
356	R:R:R282	R:R:V344	14.38	No	No	8	4	5
357	R:R:C346	R:R:R282	4.18	Yes	No	8	9	4
358	R:R:R283	R:R:S286	6.59	No	No	0	3	4
359	R:R:E287	R:R:R283	2.33	No	No	0	2	3
360	R:R:C346	R:R:V344	1.71	Yes	No	8	9	5
361	R:R:P348	R:R:S347	1.78	No	No	0	9	6
362	R:R:K349	R:R:S347	4.59	No	No	0	3	6
363	R:R:K349	R:R:P350	1.67	No	No	0	3	8
364	R:R:D351	R:R:V604	4.38	No	No	0	8	8
365	R:R:A352	R:R:V604	3.39	No	No	0	8	8
366	R:R:A352	R:R:S605	3.42	No	No	0	8	7
367	R:R:F353	R:R:N354	3.62	Yes	Yes	0	8	8
368	R:R:F353	R:R:V514	11.8	Yes	Yes	2	8	8
369	R:R:F353	R:R:M520	8.71	Yes	No	2	8	8
370	R:R:F353	R:R:V604	20.97	Yes	No	0	8	8
371	R:R:N354	R:R:P355	1.63	Yes	No	0	8	9
372	R:R:N354	R:R:Q437	2.64	Yes	Yes	0	8	9
373	R:R:K513	R:R:N354	5.6	No	Yes	0	5	8
374	R:R:P355	R:R:S515	5.34	No	No	2	9	9
375	R:R:K608	R:R:P355	3.35	Yes	No	2	9	9
376	R:R:C356	R:R:H430	13.27	No	Yes	2	9	7
377	R:R:D358	R:R:G361	1.68	No	No	0	7	8
378	R:R:D358	R:R:D422	6.65	No	Yes	2	7	9
379	R:R:D358	R:R:K426	11.06	No	Yes	2	7	5
380	R:R:I359	R:R:V421	3.07	Yes	No	2	8	7
381	R:R:D422	R:R:I359	4.2	Yes	Yes	2	9	8
382	R:R:I359	R:R:Y429	12.09	Yes	Yes	2	8	9
383	R:R:I359	R:R:W436	2.35	Yes	Yes	2	8	9
384	R:R:G361	R:R:M360	1.75	No	Yes	0	8	7
385	R:R:L365	R:R:M360	8.48	Yes	Yes	2	8	7
386	R:R:M360	R:R:R366	3.72	Yes	Yes	2	7	9
387	R:R:I369	R:R:M360	7.29	Yes	Yes	0	8	7
388	R:R:D422	R:R:M360	2.77	Yes	Yes	2	9	7
389	R:R:I609	R:R:L365	8.56	No	Yes	2	8	8
390	R:R:L365	R:R:V612	8.94	Yes	No	2	8	8
391	R:R:L365	R:R:L613	8.3	Yes	No	2	8	7
392	R:R:R366	R:R:V367	3.92	Yes	No	0	9	5
393	R:R:D422	R:R:R366	5.96	Yes	Yes	2	9	9
394	R:R:K426	R:R:R366	4.95	Yes	Yes	2	5	9
395	R:R:I369	R:R:I372	2.94	Yes	Yes	0	8	8
396	R:R:I369	R:R:L415	4.28	Yes	Yes	0	8	8
397	R:R:A419	R:R:I369	4.87	No	Yes	0	9	8
398	R:R:I369	R:R:V612	6.14	Yes	No	0	8	8
399	R:R:I374	R:R:W370	11.74	No	No	0	4	9
400	R:R:L416	R:R:W370	2.28	No	No	0	6	9
401	R:R:F371	R:R:I374	2.51	No	No	0	4	4
402	R:R:I372	R:R:P616	1.69	Yes	Yes	0	8	9
403	R:R:C620	R:R:I372	3.27	No	Yes	0	7	8
404	R:R:L415	R:R:S373	6.01	Yes	No	0	8	5
405	R:R:L416	R:R:S373	3	No	No	0	6	5
406	R:R:C620	R:R:L375	1.59	No	No	0	7	6
407	R:R:A376	R:R:G412	1.95	No	No	0	8	9
408	R:R:A376	R:R:S619	1.71	No	No	0	8	9
409	R:R:I377	R:R:L409	5.71	No	No	13	5	5
410	R:R:I377	R:R:I413	2.94	No	No	13	5	4
411	R:R:G379	R:R:T378	1.82	No	No	0	7	3
412	R:R:G379	R:R:I382	1.76	No	No	0	7	5
413	R:R:G379	R:R:P623	2.03	No	Yes	0	7	9
414	R:R:F406	R:R:N380	2.42	No	No	0	5	9
415	R:R:D408	R:R:N380	6.73	No	No	0	9	9
416	R:R:L409	R:R:N380	17.85	No	No	0	5	9
417	R:R:I381	R:R:V385	3.07	No	No	0	3	2
418	R:R:F637	R:R:I382	7.54	Yes	No	0	4	5
419	R:R:L387	R:R:V383	4.47	Yes	No	0	5	9
420	R:R:A405	R:R:V383	3.39	No	No	0	8	9
421	R:R:P623	R:R:V383	3.53	Yes	No	0	9	9
422	R:R:L384	R:R:T388	2.95	No	No	0	6	4
423	R:R:C402	R:R:L384	1.59	No	No	0	7	6
424	R:R:F406	R:R:L384	6.09	No	No	0	5	6
425	R:R:T389	R:R:V385	3.17	No	No	0	4	2
426	R:R:I386	R:R:L387	2.85	Yes	Yes	0	7	5
427	R:R:F633	R:R:I386	13.82	Yes	Yes	14	8	7
428	R:R:D636	R:R:I386	2.8	No	Yes	0	8	7
429	R:R:F637	R:R:I386	3.77	Yes	Yes	14	4	7
430	R:R:I386	R:R:L640	5.71	Yes	No	0	7	7
431	R:R:L387	R:R:R398	9.72	Yes	Yes	0	5	8
432	R:R:C402	R:R:L387	6.35	No	Yes	0	7	5
433	R:R:L640	R:R:T389	7.37	No	No	0	7	4
434	R:R:R398	R:R:S390	2.64	Yes	No	0	8	8
435	R:R:D636	R:R:S390	4.42	No	No	0	8	8
436	R:R:Q391	R:R:Y392	2.25	No	No	0	5	3
437	R:R:L394	R:R:R398	9.72	No	Yes	0	5	8
438	R:R:F399	R:R:L394	8.53	No	No	0	7	5
439	R:R:T395	R:R:V396	1.59	No	Yes	3	7	8
440	R:R:P397	R:R:T395	10.49	No	No	3	6	7
441	R:R:P397	R:R:V396	3.53	No	Yes	3	6	8
442	R:R:L400	R:R:V396	2.98	Yes	Yes	3	8	8
443	R:R:E466	R:R:V396	4.28	Yes	Yes	3	9	8
444	R:R:A486	R:R:V396	5.09	No	Yes	0	7	8
445	R:R:E466	R:R:P397	7.86	Yes	No	3	9	6
446	R:R:N632	R:R:R398	4.82	No	Yes	0	6	8
447	R:R:F399	R:R:L483	2.44	No	No	0	7	3
448	R:R:L400	R:R:T459	2.95	Yes	Yes	3	8	8
449	R:R:A462	R:R:L400	1.58	No	Yes	0	5	8
450	R:R:I463	R:R:L400	7.14	Yes	Yes	3	9	8
451	R:R:E466	R:R:L400	6.63	Yes	Yes	3	9	8
452	R:R:L400	R:R:M490	4.24	Yes	No	3	8	7
453	R:R:M401	R:R:Y626	5.99	No	Yes	0	8	9
454	R:R:A627	R:R:M401	1.61	No	No	0	7	8
455	R:R:N403	R:R:T459	4.39	No	Yes	3	8	8
456	R:R:M490	R:R:N403	11.22	No	No	3	7	8
457	R:R:L404	R:R:S456	3	Yes	No	0	8	9
458	R:R:L404	R:R:T459	7.37	Yes	Yes	0	8	8
459	R:R:L404	R:R:L460	5.54	Yes	No	0	8	9
460	R:R:L404	R:R:N622	8.24	Yes	No	0	8	9
461	R:R:A407	R:R:L455	4.73	No	No	0	8	7
462	R:R:A407	R:R:S456	3.42	No	No	0	8	9
463	R:R:D408	R:R:S619	8.83	No	No	0	9	9
464	R:R:I413	R:R:L409	8.56	No	No	13	4	5
465	R:R:C410	R:R:F448	8.38	No	No	0	7	8
466	R:R:A452	R:R:C410	3.61	No	No	0	8	7
467	R:R:G412	R:R:I411	3.53	No	Yes	0	9	7
468	R:R:A452	R:R:I411	4.87	No	Yes	0	8	7
469	R:R:H615	R:R:I411	9.28	No	Yes	2	6	7
470	R:R:I411	R:R:P616	1.69	Yes	Yes	2	7	9
471	R:R:G412	R:R:L415	1.71	No	Yes	0	9	8
472	R:R:L415	R:R:Y414	7.03	Yes	Yes	0	8	7
473	R:R:I418	R:R:Y414	4.84	No	Yes	0	8	7
474	R:R:A445	R:R:Y414	2.67	Yes	Yes	0	8	7
475	R:R:T449	R:R:Y414	21.22	No	Yes	0	8	7
476	R:R:I516	R:R:Y414	4.84	Yes	Yes	0	8	7
477	R:R:L415	R:R:P616	6.57	Yes	Yes	0	8	9
478	R:R:L416	R:R:S420	3	No	No	0	6	4
479	R:R:L417	R:R:W436	2.28	No	Yes	0	5	9
480	R:R:A445	R:R:L417	1.58	Yes	No	0	8	5
481	R:R:V421	R:R:W436	20.84	No	Yes	2	7	9
482	R:R:D422	R:R:I423	2.8	Yes	No	2	9	5
483	R:R:D422	R:R:K426	2.77	Yes	Yes	2	9	5
484	R:R:I423	R:R:K426	4.36	No	Yes	2	5	5
485	R:R:T425	R:R:Y429	11.24	No	Yes	0	9	9
486	R:R:K426	R:R:S427	3.06	Yes	No	0	5	7
487	R:R:A433	R:R:Y429	5.34	No	Yes	2	9	9
488	R:R:W436	R:R:Y429	8.68	Yes	Yes	2	9	9
489	R:R:Q437	R:R:Y429	4.51	Yes	Yes	2	9	9
490	R:R:S515	R:R:Y429	6.36	No	Yes	2	9	9
491	R:R:A433	R:R:Q437	3.03	No	Yes	2	9	9
492	R:R:D435	R:R:I434	5.6	No	No	0	4	7
493	R:R:G441	R:R:W436	4.22	No	Yes	0	7	9
494	R:R:C442	R:R:W436	10.45	No	Yes	0	9	9
495	R:R:A444	R:R:G441	1.95	No	No	0	5	7
496	R:R:C442	R:R:C517	5.46	No	No	0	9	9
497	R:R:D443	R:R:I505	5.6	No	No	0	4	7
498	R:R:D443	R:R:Y511	5.75	No	Yes	0	4	8
499	R:R:A445	R:R:G446	1.95	Yes	Yes	2	8	9
500	R:R:A445	R:R:C517	3.61	Yes	No	2	8	9
501	R:R:G446	R:R:T449	1.82	Yes	No	0	9	8
502	R:R:G446	R:R:Y511	10.14	Yes	Yes	2	9	8
503	R:R:C517	R:R:G446	1.96	No	Yes	2	9	9
504	R:R:F447	R:R:F448	10.72	Yes	No	0	8	8
505	R:R:F447	R:R:F498	6.43	Yes	No	0	8	4
506	R:R:A501	R:R:F447	5.55	No	Yes	0	9	8
507	R:R:F447	R:R:I505	2.51	Yes	No	0	8	7
508	R:R:F447	R:R:Y511	2.06	Yes	Yes	0	8	8
509	R:R:S453	R:R:V450	1.62	No	Yes	0	8	8
510	R:R:E454	R:R:V450	4.28	No	Yes	0	8	8
511	R:R:A501	R:R:V450	3.39	No	Yes	0	9	8
512	R:R:V450	R:R:Y511	6.31	Yes	Yes	2	8	8
513	R:R:P519	R:R:V450	1.77	Yes	Yes	2	9	8
514	R:R:F451	R:R:W494	12.03	No	No	0	8	6
515	R:R:A497	R:R:F451	5.55	No	No	0	7	8
516	R:R:F451	R:R:F498	2.14	No	No	0	8	4
517	R:R:A500	R:R:E454	6.03	No	No	0	6	8
518	R:R:E454	R:R:L534	11.93	No	No	0	8	6
519	R:R:L455	R:R:T459	2.95	No	Yes	0	7	8
520	R:R:V457	R:R:Y458	3.79	Yes	Yes	0	8	7
521	R:R:T461	R:R:V457	1.59	No	Yes	15	8	8
522	R:R:N538	R:R:V457	4.43	No	Yes	0	9	8
523	R:R:A541	R:R:V457	1.7	No	Yes	15	9	8
524	R:R:G493	R:R:Y458	5.79	No	Yes	0	8	7
525	R:R:F496	R:R:Y458	10.32	No	Yes	0	5	7
526	R:R:L537	R:R:Y458	3.52	No	Yes	0	4	7
527	R:R:M490	R:R:T459	3.01	No	Yes	3	7	8
528	R:R:L460	R:R:L577	8.3	No	No	0	9	9
529	R:R:D581	R:R:L460	4.07	No	No	0	9	9
530	R:R:L465	R:R:T461	2.95	No	No	0	5	8
531	R:R:A541	R:R:T461	1.68	No	No	15	9	8
532	R:R:A462	R:R:V489	1.7	No	No	0	5	5
533	R:R:E466	R:R:I463	5.47	Yes	Yes	3	9	9
534	R:R:I463	R:R:M574	4.37	Yes	Yes	3	9	9
535	R:R:I463	R:R:Y626	2.42	Yes	Yes	3	9	9
536	R:R:I545	R:R:T464	13.68	No	No	3	8	8
537	R:R:C548	R:R:T464	5.07	No	No	0	6	8
538	R:R:M574	R:R:T464	6.02	Yes	No	3	9	8
539	R:R:H469	R:R:L465	2.57	Yes	No	0	5	5
540	R:R:D478	R:R:E466	7.8	Yes	Yes	0	4	9
541	R:R:R467	R:R:T470	2.59	Yes	No	0	9	8
542	R:R:R467	R:R:Y549	5.14	Yes	Yes	3	9	9
543	R:R:I552	R:R:R467	21.3	No	Yes	0	8	9
544	R:R:I570	R:R:R467	2.51	No	Yes	0	7	9
545	R:R:M574	R:R:R467	17.37	Yes	Yes	3	9	9
546	R:R:H469	R:R:W468	10.58	Yes	Yes	0	5	5
547	R:R:T472	R:R:W468	16.98	No	Yes	0	5	5
548	R:R:C548	R:R:W468	3.92	No	Yes	0	6	5
549	R:R:H551	R:R:W468	9.52	No	Yes	0	4	5
550	R:R:D478	R:R:H469	2.52	Yes	Yes	0	4	5
551	R:R:C479	R:R:H469	10.32	No	Yes	0	6	5
552	R:R:D478	R:R:T470	5.78	Yes	No	0	4	8
553	R:R:I471	R:R:T472	3.04	No	No	0	8	5
554	R:R:I471	R:R:I552	8.83	No	No	0	8	8
555	R:R:I471	R:R:T555	7.6	No	No	0	8	6
556	R:R:H473	R:R:Q476	6.18	No	No	17	4	5
557	R:R:C479	R:R:H473	7.37	No	No	17	6	4
558	R:R:M475	R:R:Q476	10.88	No	No	0	5	5
559	R:R:C479	R:R:Q476	9.16	No	No	17	6	5
560	R:R:D478	R:R:V481	13.15	Yes	No	0	4	6
561	R:R:K480	R:R:Q482	5.42	No	No	0	7	5
562	R:R:H485	R:R:V481	6.92	No	No	0	5	6
563	R:R:H485	R:R:S488	2.79	No	No	16	5	3
564	R:R:H485	R:R:V489	5.54	No	No	16	5	5
565	R:R:S488	R:R:V489	1.62	No	No	16	3	5
566	R:R:I495	R:R:V491	3.07	No	No	0	1	1
567	R:R:G493	R:R:M492	1.75	No	No	0	8	2
568	R:R:I505	R:R:L502	5.71	No	No	0	7	3
569	R:R:F506	R:R:L502	2.44	No	No	0	3	3
570	R:R:F503	R:R:I508	6.28	No	Yes	2	7	6
571	R:R:F503	R:R:Y530	16.5	No	No	2	7	7
572	R:R:P504	R:R:Y511	19.47	No	Yes	2	9	8
573	R:R:P504	R:R:P519	1.95	No	Yes	2	9	9
574	R:R:I508	R:R:L526	2.85	Yes	No	0	6	4
575	R:R:I508	R:R:S527	3.1	Yes	Yes	2	6	7
576	R:R:I508	R:R:Y530	9.67	Yes	No	2	6	7
577	R:R:P519	R:R:S509	1.78	Yes	No	2	9	8
578	R:R:D521	R:R:S509	7.36	Yes	No	2	8	8
579	R:R:S509	R:R:S527	6.52	No	Yes	2	8	7
580	R:R:P519	R:R:Y511	11.13	Yes	Yes	2	9	8
581	R:R:K513	R:R:V514	3.04	No	Yes	0	5	8
582	R:R:I516	R:R:V514	4.61	Yes	Yes	2	8	8
583	R:R:M520	R:R:V514	3.04	No	Yes	2	8	8
584	R:R:K608	R:R:V514	3.04	Yes	Yes	2	9	8
585	R:R:K608	R:R:S515	6.12	Yes	No	2	9	9
586	R:R:I516	R:R:L518	2.85	Yes	Yes	2	8	8
587	R:R:I516	R:R:K608	2.91	Yes	Yes	2	8	9
588	R:R:I516	R:R:L611	4.28	Yes	No	2	8	7
589	R:R:L518	R:R:P519	4.93	Yes	Yes	2	8	9
590	R:R:L518	R:R:M520	2.83	Yes	No	2	8	8
591	R:R:L518	R:R:L611	4.15	Yes	No	2	8	7
592	R:R:D521	R:R:D523	6.65	Yes	No	0	8	5
593	R:R:D521	R:R:S527	4.42	Yes	Yes	2	8	7
594	R:R:I522	R:R:Q528	10.98	No	No	0	6	6
595	R:R:D523	R:R:S524	8.83	No	No	0	5	5
596	R:R:P525	R:R:S524	3.56	No	No	0	4	5
597	R:R:S527	R:R:V531	1.62	Yes	No	0	7	7
598	R:R:L529	R:R:Q528	2.66	No	No	0	4	6
599	R:R:S596	R:R:V531	1.62	No	No	0	7	7
600	R:R:M532	R:R:V536	4.56	No	No	0	6	5
601	R:R:L534	R:R:N538	4.12	No	No	0	6	9
602	R:R:L535	R:R:S589	3	No	No	0	8	9
603	R:R:A592	R:R:L535	4.73	No	No	0	8	8
604	R:R:I593	R:R:L535	7.14	No	No	0	7	8
605	R:R:M585	R:R:N538	4.21	Yes	No	0	7	9
606	R:R:L540	R:R:V544	2.98	No	No	0	4	4
607	R:R:C546	R:R:F542	5.59	No	No	0	7	9
608	R:R:F542	R:R:F582	20.36	No	No	0	9	8
609	R:R:V543	R:R:V544	1.6	No	No	0	4	4
610	R:R:I545	R:R:M574	4.37	No	Yes	3	8	9
611	R:R:I545	R:R:I578	8.83	No	Yes	3	8	9
612	R:R:C546	R:R:G547	1.96	No	No	0	7	2
613	R:R:C546	R:R:I578	4.91	No	Yes	0	7	9
614	R:R:G547	R:R:I550	1.76	No	No	0	2	5
615	R:R:Y549	R:R:Y553	16.88	Yes	No	0	9	8
616	R:R:M574	R:R:Y549	2.39	Yes	Yes	3	9	9
617	R:R:A575	R:R:Y549	6.67	No	Yes	3	9	9
618	R:R:I578	R:R:Y549	6.04	Yes	Yes	3	9	9
619	R:R:H551	R:R:I550	2.65	No	No	0	4	5
620	R:R:A571	R:R:Y553	2.67	No	No	0	8	8
621	R:R:S563	R:R:V556	6.46	No	No	0	5	8
622	R:R:T568	R:R:V556	1.59	No	No	0	6	8
623	R:R:A571	R:R:V556	1.7	No	No	0	8	8
624	R:R:N558	R:R:P559	8.15	No	No	0	7	7
625	R:R:N558	R:R:N560	5.45	No	No	0	7	5
626	R:R:I561	R:R:N558	5.66	No	No	0	3	7
627	R:R:S564	R:R:S566	1.63	No	No	0	5	5
628	R:R:D567	R:R:S564	7.36	No	No	0	8	5
629	R:R:S565	R:R:T568	1.6	No	No	0	4	6
630	R:R:R569	R:R:R573	3.2	No	Yes	0	6	9
631	R:R:I570	R:R:R573	10.02	No	Yes	0	7	9
632	R:R:R573	R:R:Y626	3.09	Yes	Yes	0	9	9
633	R:R:R573	R:R:T630	2.59	Yes	No	0	9	9
634	R:R:I578	R:R:M574	5.83	Yes	Yes	3	9	9
635	R:R:M574	R:R:Y626	3.59	Yes	Yes	3	9	9
636	R:R:A575	R:R:I578	1.62	No	Yes	3	9	9
637	R:R:L625	R:R:M576	18.38	No	No	0	8	5
638	R:R:L577	R:R:Y626	17.58	No	Yes	0	9	9
639	R:R:F579	R:R:F582	2.14	No	No	0	7	8
640	R:R:F579	R:R:L583	17.05	No	No	0	7	6
641	R:R:N618	R:R:T580	5.85	No	No	0	9	8
642	R:R:A621	R:R:T580	1.68	No	No	0	7	8
643	R:R:L625	R:R:T580	4.42	No	No	0	8	8
644	R:R:D581	R:R:M585	8.32	No	Yes	0	9	7
645	R:R:A586	R:R:F582	5.55	No	No	0	7	8
646	R:R:C584	R:R:M585	1.62	No	Yes	0	9	7
647	R:R:C584	R:R:N618	7.87	No	No	0	9	9
648	R:R:I588	R:R:M585	5.83	No	Yes	0	9	7
649	R:R:M585	R:R:S589	6.13	Yes	No	0	7	9
650	R:R:A586	R:R:P587	1.87	No	No	0	7	9
651	R:R:L610	R:R:P587	1.64	No	No	18	8	9
652	R:R:F614	R:R:P587	2.89	No	No	18	7	9
653	R:R:F591	R:R:S594	5.28	Yes	No	0	8	8
654	R:R:A595	R:R:F591	2.77	No	Yes	0	9	8
655	R:R:F591	R:R:I602	27.63	Yes	Yes	19	8	8
656	R:R:A607	R:R:F591	4.16	No	Yes	19	7	8
657	R:R:I593	R:R:L597	2.85	No	No	0	7	5
658	R:R:S594	R:R:V599	1.62	No	No	0	8	5
659	R:R:L597	R:R:V599	4.47	No	No	0	5	5
660	R:R:P600	R:R:V599	1.77	No	No	0	6	5
661	R:R:I602	R:R:K606	4.36	Yes	No	0	8	6
662	R:R:A607	R:R:I602	3.25	No	Yes	19	7	8
663	R:R:S605	R:R:T603	3.2	No	No	0	7	7
664	R:R:I609	R:R:L613	2.85	No	No	2	8	7
665	R:R:F614	R:R:L610	4.87	No	No	18	7	8
666	R:R:H615	R:R:L611	6.43	No	No	2	6	7
667	R:R:L613	R:R:V612	4.47	No	No	2	7	8
668	R:R:H615	R:R:P616	6.1	No	Yes	2	6	9
669	R:R:N622	R:R:P623	9.77	No	Yes	0	9	9
670	R:R:N622	R:R:Y626	3.49	No	Yes	0	9	9
671	R:R:I628	R:R:P623	3.39	No	Yes	0	7	9
672	R:R:F624	R:R:I628	11.3	No	No	0	8	7
673	R:R:L625	R:R:Y626	3.52	No	Yes	0	8	9
674	R:R:A627	R:R:F633	6.93	No	Yes	0	7	8
675	R:R:F633	R:R:I628	11.3	Yes	No	0	8	7
676	R:R:D636	R:R:N632	4.04	No	No	0	8	6
677	R:R:F633	R:R:F637	2.14	Yes	Yes	14	8	4
678	R:R:F638	R:R:R634	10.69	No	No	0	3	7
679	R:R:I639	R:R:R635	2.51	No	No	0	4	5
680	R:R:F637	R:R:L641	20.7	Yes	No	0	4	4
681	R:R:F638	R:R:L641	6.09	No	No	0	3	4
682	R:R:C188	R:R:N163	1.57	No	Yes	7	4	7
683	R:R:C188	R:R:N191	1.57	No	Yes	7	4	5
684	R:R:A115	R:R:N112	1.56	Yes	No	0	8	5
685	R:R:I522	R:R:S596	1.55	No	No	0	6	7
686	R:R:I593	R:R:V539	1.54	No	No	0	7	7
687	R:R:K36	R:R:S35	1.53	No	No	0	5	3
688	R:R:M512	R:R:S510	1.53	No	No	0	5	6
689	R:R:M532	R:R:S533	1.53	No	No	0	6	4
690	R:R:C356	R:R:E357	1.52	No	No	0	9	7
691	R:R:I434	R:R:T438	1.52	No	No	0	7	5
692	R:R:I561	R:R:T555	1.52	No	No	0	3	6
693	R:R:K57	R:R:T38	1.5	No	No	0	3	1
694	R:R:N27	R:R:S26	1.49	No	No	0	1	4
695	R:R:L465	R:R:V544	1.49	No	No	0	5	4
696	R:R:D196	R:R:S172	1.47	No	No	0	4	5
697	R:R:D224	R:R:S201	1.47	Yes	No	0	9	7
698	R:R:I372	R:R:I617	1.47	Yes	No	0	8	7
699	R:R:D521	R:R:S510	1.47	Yes	No	0	8	6
700	R:R:G237	R:R:Y236	1.45	No	No	0	8	2
701	R:R:I434	R:R:K253	1.45	No	No	0	7	6
702	R:R:K572	R:R:M576	1.44	No	No	0	8	5
703	R:R:I285	R:R:L258	1.43	No	No	0	1	6
704	R:R:I372	R:R:L368	1.43	Yes	No	0	8	6
705	R:R:I602	R:R:L601	1.43	Yes	No	0	8	6
706	R:R:Q428	R:R:T425	1.42	No	No	0	5	9
707	R:R:K133	R:R:N156	1.4	No	No	0	4	4
708	R:R:H231	R:R:S232	1.39	No	No	0	4	5
709	R:R:A499	R:R:F503	1.39	No	No	0	4	7
710	R:R:H158	R:R:T159	1.37	No	No	0	3	3
711	R:R:E266	R:R:K243	1.35	No	Yes	0	4	5
712	R:R:E259	R:R:K260	1.35	No	No	0	4	4
713	R:R:N431	R:R:Q428	1.32	No	No	0	5	5
714	R:R:D137	R:R:E161	1.3	No	No	0	7	6
715	R:R:H158	R:R:N205	1.28	No	No	0	3	2
716	R:R:E184	R:R:E208	1.27	No	No	0	4	1
717	R:R:T425	R:R:Y432	1.25	No	No	0	9	5
718	R:R:K631	R:R:R569	1.24	No	No	0	7	6
719	R:R:F629	R:R:M576	1.24	No	No	0	6	5
720	R:R:I364	R:R:Y362	1.21	No	No	0	4	7
721	R:R:I609	R:R:Y362	1.21	No	No	0	8	7
722	R:R:N363	R:R:R366	1.21	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H20	8.7625	4	1	7
2	R:R:I22	4.53167	6	1	4
3	R:R:C23	5.3725	4	1	8
4	R:R:F30	9.89833	6	1	5
5	R:R:C32	5.74	6	1	9
6	R:R:V37	6.425	4	1	6
7	R:R:P41	2.92	5	1	9
8	R:R:L44	8.56	5	1	2
9	R:R:L51	8.264	5	1	8
10	R:R:F53	6.28333	6	1	6
11	R:R:I61	4.1875	4	1	8
12	R:R:F66	10.2417	6	1	8
13	R:R:F69	10.045	4	1	6
14	R:R:L72	6.9575	4	1	7
15	R:R:I75	5.954	5	1	7
16	R:R:E76	6.3025	4	5	5
17	R:R:I86	4.524	5	1	8
18	R:R:D89	4.412	5	9	3
19	R:R:F91	7.13167	6	1	9
20	R:R:L94	5.96	4	1	8
21	R:R:L97	5.2125	4	1	8
22	R:R:H98	6.6	4	0	4
23	R:R:I100	6.0575	4	1	8
24	R:R:R101	5.8275	4	5	5
25	R:R:L108	4.344	5	1	9
26	R:R:I111	5.336	5	1	9
27	R:R:A115	3.6875	4	1	8
28	R:R:F116	6.646	5	1	9
29	R:R:L119	6.39	4	1	8
30	R:R:L122	6.032	5	1	9
31	R:R:Y124	6.2725	4	0	6
32	R:R:I127	3.98167	6	1	9
33	R:R:T130	4.592	5	1	8
34	R:R:P136	5.675	4	1	9
35	R:R:I141	6.706	5	1	8
36	R:R:S143	5.1075	4	1	8
37	R:R:V147	6.528	5	1	6
38	R:R:D150	7.725	4	0	7
39	R:R:I151	7.11833	6	1	7
40	R:R:Q152	5.73	4	10	7
41	R:R:N154	7.01	5	1	9
42	R:R:I157	3.9475	4	1	7
43	R:R:I160	4.732	5	1	6
44	R:R:N163	9.32	4	7	7
45	R:R:F165	4.64833	6	0	7
46	R:R:V166	4.0825	4	7	1
47	R:R:L168	6.23	5	1	5
48	R:R:S169	5.5525	4	1	4
49	R:R:I174	8.7375	4	4	5
50	R:R:L177	6.9825	4	1	9
51	R:R:N180	6.76167	6	1	9
52	R:R:I182	3.728	5	1	8
53	R:R:I185	5.06167	6	1	7
54	R:R:A189	3.97	5	1	8
55	R:R:F190	5.23167	6	1	9
56	R:R:N191	6.0025	4	7	5
57	R:R:L195	5.9	6	1	9
58	R:R:E197	10.115	4	4	5
59	R:R:L198	6.705	4	1	7
60	R:R:N203	4.6	4	0	9
61	R:R:L209	4.696	5	1	7
62	R:R:P210	4	5	1	6
63	R:R:V213	3.766	5	1	8
64	R:R:F214	4.572	5	1	9
65	R:R:P220	4.304	5	1	8
66	R:R:I222	8.9	5	4	3
67	R:R:L223	4.5625	4	1	8
68	R:R:D224	7.8275	4	4	9
69	R:R:T228	7.5925	4	0	9
70	R:R:L233	4.512	5	6	8
71	R:R:L238	3.87	4	6	8
72	R:R:K243	5.7875	4	4	5
73	R:R:A246	2.035	4	6	8
74	R:R:L252	7.605	4	6	8
75	R:R:L255	4.5275	4	6	6
76	R:R:W281	5.28	4	8	5
77	R:R:C346	3.285	4	8	9
78	R:R:F353	11.275	4	2	8
79	R:R:N354	4.328	5	0	8
80	R:R:I359	5.4275	4	2	8
81	R:R:M360	4.802	5	2	7
82	R:R:L365	8.57	4	2	8
83	R:R:R366	3.952	5	2	9
84	R:R:I369	5.104	5	0	8
85	R:R:I372	2.16	5	0	8
86	R:R:I386	5.79	5	14	7
87	R:R:L387	5.8475	4	0	5
88	R:R:V396	3.494	5	3	8
89	R:R:R398	6.725	4	0	8
90	R:R:L400	4.25333	6	3	8
91	R:R:L404	6.0375	4	0	8
92	R:R:I411	4.8425	4	2	7
93	R:R:Y414	8.12	5	0	7
94	R:R:L415	5.12	5	0	8
95	R:R:D422	4.19167	6	2	9
96	R:R:K426	5.24	5	2	5
97	R:R:Y429	8.03667	6	2	9
98	R:R:H430	6.628	5	2	7
99	R:R:W436	8.13667	6	2	9
100	R:R:Q437	3.6275	4	2	9
101	R:R:A445	2.4525	4	2	8
102	R:R:G446	3.9675	4	2	9
103	R:R:F447	5.454	5	0	8
104	R:R:V450	3.474	5	2	8
105	R:R:V457	2.8775	4	15	8
106	R:R:Y458	5.855	4	0	7
107	R:R:T459	4.134	5	3	8
108	R:R:I463	4.85	4	3	9
109	R:R:E466	6.408	5	3	9
110	R:R:R467	9.782	5	3	9
111	R:R:W468	10.25	4	0	5
112	R:R:H469	6.4975	4	0	5
113	R:R:D478	7.3125	4	0	4
114	R:R:I508	5.475	4	2	6
115	R:R:Y511	9.14333	6	2	8
116	R:R:V514	5.106	5	2	8
117	R:R:I516	3.898	5	2	8
118	R:R:L518	3.69	4	2	8
119	R:R:P519	4.312	5	2	9
120	R:R:D521	4.975	4	2	8
121	R:R:S527	3.915	4	2	7
122	R:R:Y549	7.424	5	3	9
123	R:R:R573	4.725	4	0	9
124	R:R:M574	6.27714	7	3	9
125	R:R:I578	5.446	5	3	9
126	R:R:M585	5.222	5	0	7
127	R:R:F591	9.96	4	19	8
128	R:R:I602	9.1675	4	19	8
129	R:R:K608	3.855	4	2	9
130	R:R:P616	4.0125	4	2	9
131	R:R:P623	4.68	4	0	9
132	R:R:Y626	5.66857	7	3	9
133	R:R:F633	8.5475	4	14	8
134	R:R:F637	8.5375	4	14	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I75	R:R:L97	28.03	2.85	Yes	Yes	1	7	8
2	R:R:L119	R:R:L97	24.8732	2.77	Yes	Yes	1	8	8
3	R:R:L119	R:R:P120	23.591	1.64	Yes	No	0	8	8
4	R:R:N121	R:R:P120	21.8698	1.63	No	No	0	4	8
5	R:R:H98	R:R:N121	21.5248	10.2	Yes	No	0	4	4
6	R:R:H98	R:R:Q123	19.796	9.89	Yes	No	0	4	5
7	R:R:E99	R:R:Q123	19.1027	3.82	No	No	0	6	5
8	R:R:E99	R:R:Y124	17.7131	6.73	No	Yes	0	6	6
9	R:R:A115	R:R:N112	17.2698	1.56	Yes	No	0	8	5
10	R:R:A88	R:R:N112	14.6241	4.69	No	No	0	5	5
11	R:R:A88	R:R:D89	10.6377	3.09	No	Yes	9	5	3
12	R:R:I100	R:R:I75	36.5175	2.94	Yes	Yes	1	8	7
13	R:R:I100	R:R:L125	42.2172	9.99	Yes	No	0	8	8
14	R:R:F116	R:R:P136	14.4894	4.33	Yes	Yes	1	9	9
15	R:R:L125	R:R:L149	42.2365	2.77	No	No	0	8	8
16	R:R:I127	R:R:I151	10.5064	2.94	Yes	Yes	1	9	7
17	R:R:L135	R:R:P136	25.9619	8.21	No	Yes	0	7	9
18	R:R:F165	R:R:L149	42.6532	3.65	Yes	No	0	7	8
19	R:R:F165	R:R:F190	36.4256	4.29	Yes	Yes	0	7	9
20	R:R:F190	R:R:V213	35.0948	3.93	Yes	Yes	1	9	8
21	R:R:I151	R:R:L177	11.3001	8.56	Yes	Yes	1	7	9
22	R:R:F165	R:R:L175	32.4631	10.96	Yes	No	0	7	7
23	R:R:L175	R:R:L198	32.0501	5.54	No	Yes	0	7	7
24	R:R:L177	R:R:L200	14.5606	5.54	Yes	No	0	9	9
25	R:R:L198	R:R:L200	15.6363	12.46	Yes	No	0	7	9
26	R:R:L198	R:R:L223	47.5955	5.54	Yes	Yes	1	7	8
27	R:R:P234	R:R:V213	40.613	3.53	No	Yes	0	9	8
28	R:R:L223	R:R:L241	49.4083	6.92	Yes	No	0	8	7
29	R:R:L233	R:R:P234	47.9786	1.64	Yes	No	0	8	9
30	R:R:L238	R:R:L241	49.5199	6.92	Yes	No	0	8	7
31	R:R:L233	R:R:L238	49.0708	2.77	Yes	Yes	6	8	8
32	R:R:L238	R:R:L261	99.1686	4.15	Yes	No	0	8	7
33	R:R:L261	R:R:L264	99.226	6.92	No	No	0	7	6
34	R:R:A267	R:R:L264	99.2831	1.58	No	No	0	8	6
35	R:R:A267	R:R:C346	99.34	3.61	No	Yes	0	8	9
36	R:R:C275	R:R:C346	99.9462	3.64	No	Yes	0	9	9
37	R:R:C275	R:R:P350	100	7.53	No	No	0	9	8
38	R:R:C276	R:R:P350	68.9739	7.53	No	No	0	9	8
39	R:R:C276	R:R:H430	68.8033	10.32	No	Yes	2	9	7
40	R:R:H430	R:R:S273	69.0229	2.79	Yes	No	2	7	8
41	R:R:Q437	R:R:S273	50.0376	4.33	Yes	No	2	9	8
42	R:R:N354	R:R:Q437	31.1649	2.64	Yes	Yes	0	8	9
43	R:R:F353	R:R:N354	43.2268	3.62	Yes	Yes	0	8	8
44	R:R:F353	R:R:M520	33.0834	8.71	Yes	No	2	8	8
45	R:R:L518	R:R:M520	32.9808	2.83	Yes	No	2	8	8
46	R:R:L518	R:R:P519	32.8461	4.93	Yes	Yes	2	8	9
47	R:R:K349	R:R:P350	31.1067	1.67	No	No	0	3	8
48	R:R:K349	R:R:S347	31.0643	4.59	No	No	0	3	6
49	R:R:P348	R:R:S347	31.0328	1.78	No	No	0	9	6
50	R:R:P272	R:R:P348	31.0016	7.79	No	No	0	7	9
51	R:R:N354	R:R:P272	30.9711	8.15	Yes	No	0	8	7
52	R:R:A433	R:R:S273	18.9928	3.42	No	No	2	9	8
53	R:R:A433	R:R:Y429	18.9841	5.34	No	Yes	2	9	9
54	R:R:Q437	R:R:Y429	18.9834	4.51	Yes	Yes	2	9	9
55	R:R:I359	R:R:Y429	12.3707	12.09	Yes	Yes	2	8	9
56	R:R:D422	R:R:I359	12.3542	4.2	Yes	Yes	2	9	8
57	R:R:D422	R:R:M360	10.4324	2.77	Yes	Yes	2	9	7
58	R:R:W436	R:R:Y429	15.6018	8.68	Yes	Yes	2	9	9
59	R:R:L417	R:R:W436	11.622	2.28	No	Yes	0	5	9
60	R:R:A445	R:R:L417	11.4684	1.58	Yes	No	0	8	5
61	R:R:L415	R:R:Y414	37.9168	7.03	Yes	Yes	0	8	7
62	R:R:I516	R:R:K608	18.2818	2.91	Yes	Yes	2	8	9
63	R:R:I516	R:R:Y414	31.7752	4.84	Yes	Yes	0	8	7
64	R:R:I516	R:R:V514	18.1482	4.61	Yes	Yes	2	8	8
65	R:R:A376	R:R:G412	34.2712	1.95	No	No	0	8	9
66	R:R:G412	R:R:L415	35.2525	1.71	No	Yes	0	9	8
67	R:R:A376	R:R:S619	33.1623	1.71	No	No	0	8	9
68	R:R:D408	R:R:S619	32.0592	8.83	No	No	0	9	9
69	R:R:D408	R:R:N380	30.9698	6.73	No	No	0	9	9
70	R:R:P519	R:R:V450	26.1925	1.77	Yes	Yes	2	9	8
71	R:R:E454	R:R:V450	27.9033	4.28	No	Yes	0	8	8
72	R:R:E454	R:R:L534	27.523	11.93	No	No	0	8	6
73	R:R:L534	R:R:N538	27.3331	4.12	No	No	0	6	9
74	R:R:M585	R:R:N538	17.9059	4.21	Yes	No	0	7	9
75	R:R:D581	R:R:M585	12.8672	8.32	No	Yes	0	9	7
76	R:R:D581	R:R:L460	12.6702	4.07	No	No	0	9	9
77	R:R:F406	R:R:N380	26.6334	2.42	No	No	0	5	9
78	R:R:F406	R:R:L384	25.5493	6.09	No	No	0	5	6
79	R:R:C402	R:R:L384	23.3828	1.59	No	No	0	7	6
80	R:R:C402	R:R:L387	22.3006	6.35	No	Yes	0	7	5
81	R:R:I386	R:R:L387	12.1794	2.85	Yes	Yes	0	7	5
82	R:R:F165	R:R:L135	26.6305	2.44	Yes	No	0	7	7
83	R:R:I111	R:R:P136	10.8761	8.47	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8I2H

PDB Summary
PDB	8I2H
Class	A
SubFamily	Protein
Type	Glycoprotein Hormone
SubType	FSH
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	6
Date	2023-03-22
D.O.I.	doi.org/10.1038/s41467-023-36170-3

Net Summary
I_min	1.58
Number of Linked Nodes	543
Number of Links	722
Number of Hubs	134
Number of Links mediated by Hubs	452
Number of Communities	19
Number of Nodes involved in Communities	195
Number of Links involved in Communities	295

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	979927
Length Of Smallest Path	3
Average Path Length	31.0491
Length of Longest Path	57
Minimum Path Strength	1.21
Average Path Strength	5.29208
Maximum Path Strength	19.335
Minimum Path Correlation	0.7
Average Path Correlation	0.975794
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	42.2991
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.2813
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • gonad development • reproductive system development • reproductive process • sex differentiation • animal organ development • developmental process involved in reproduction • male gonad development • male sex differentiation • multicellular organism development • development of primary male sexual characteristics • development of primary sexual characteristics • anatomical structure development • reproductive structure development • system development • spermatogenesis • sexual reproduction • multicellular organismal reproductive process • male gamete generation • gamete generation • Sertoli cell proliferation • cell population proliferation • cellular process • epithelial cell proliferation • cellular response to stimulus • ovulation cycle process • regulation of cellular process • response to stimulus • signaling • development of primary female sexual characteristics • cell communication • ovulation cycle • signal transduction • ovarian follicle development • rhythmic process • regulation of biological process • female gonad development • biological regulation • female sex differentiation • follicle-stimulating hormone signaling pathway • G protein-coupled receptor signaling pathway • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • negative regulation of biological process • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • regulation of multicellular organismal process • negative regulation of multicellular organismal process • cellular response to gonadotropin stimulus • response to endogenous stimulus • response to gonadotropin • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • cellular response to follicle-stimulating hormone stimulus • response to chemical • response to follicle-stimulating hormone • cellular response to hormone stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • system process • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • cellular developmental process • cell development • epithelial cell differentiation • Sertoli cell differentiation • cell differentiation • epithelium development • Sertoli cell development • tissue development • epithelial cell development • regulation of amine metabolic process • primary metabolic process • regulation of acetylcholine metabolic process • regulation of primary metabolic process • amine metabolic process • acetylcholine metabolic process • metabolic process • regulation of metabolic process • plasma membrane bounded cell projection organization • cell projection organization • neuron projection development • nervous system development • cellular component organization • generation of neurons • neurogenesis • neuron differentiation • neuron development • cellular component organization or biogenesis • developmental growth • growth • primary ovarian follicle growth • behavior • locomotory behavior • regulation of cellular component organization • chromosome organization • regulation of chromosome organization • regulation of organelle organization • organelle organization • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of hormone metabolic process • regulation of hormone levels • hormone metabolic process • hormone-mediated signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of cellular component size • cell volume homeostasis • cellular homeostasis • intracellular water homeostasis • chemical homeostasis • intracellular chemical homeostasis • regulation of cell size • regulation of anatomical structure size • extracellular matrix organization • basement membrane organization • extracellular structure organization • external encapsulating structure organization • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • uterus development • female gamete generation • spermatid development • spermatid differentiation • cellular process involved in reproduction in multicellular organism • chromatin organization • sperm DNA condensation • nucleus organization • germ cell development • spermatid nucleus differentiation • myeloid leukocyte differentiation • regulation of leukocyte differentiation • regulation of developmental process • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • osteoclast differentiation • regulation of immune system process • regulation of multicellular organismal development • hemopoiesis • regulation of myeloid cell differentiation • regulation of myeloid leukocyte differentiation • myeloid cell differentiation • immune system process • regulation of hemopoiesis • leukocyte differentiation • localization • transport • establishment of localization • transcytosis • vesicle-mediated transport • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • platelet-derived growth factor receptor signaling pathway • regulation of platelet-derived growth factor receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • intracellular receptor signaling pathway • response to lipid • positive regulation of intracellular estrogen receptor signaling pathway • response to steroid hormone • regulation of intracellular estrogen receptor signaling pathway • regulation of intracellular steroid hormone receptor signaling pathway • nuclear receptor-mediated steroid hormone signaling pathway • cellular response to steroid hormone stimulus • steroid hormone receptor signaling pathway • estrogen receptor signaling pathway • positive regulation of intracellular steroid hormone receptor signaling pathway • cellular response to lipid • nuclear receptor-mediated signaling pathway • cellular anatomical structure • membrane • protein-containing complex • receptor complex • cell surface • cell periphery • plasma membrane • membrane-bounded organelle • intracellular anatomical structure • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • receptor complex • cell surface • cell periphery • plasma membrane • membrane-bounded organelle • intracellular anatomical structure • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • cytoplasm • vesicle
SCOP2	Domain Identifier	• L domain-like
SCOP2	Family Identifier	• L domain-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P23945
Sequence	>8I2H_Chain_R H R I C H C S N R V F L C Q E S K V T E I P S D L P R N A I E L R F V L T K L R V I Q K G A F S G F G D L E K I E I S Q N D V L E V I E A D V F S N L P K L H E I R I E K A N N L L Y I N P E A F Q N L P N L Q Y L L I S N T G I K H L P D V H K I H S L Q K V L L D I Q D N I N I H T I E R N S F V G L S F E S V I L W L N K N G I Q E I H N C A F N G T Q L D E L N L S D N N N L E E L P N D V F H G A S G P V I L D I S R T R I H S L P S Y G L E N L K K L R A R S T Y N L K K L P T L E K L V A L M E A S L T Y P S H C C A F A N W R R Q I S E V T C S P K P D A F N P C E D I M G Y N I L R V L I W F I S I L A I T G N I I V L V I L T T S Q Y K L T V P R F L M C N L A F A D L C I G I Y L L L I A S V D I H T K S Q Y H N Y A I D W Q T G A G C D A A G F F T V F A S E L S V Y T L T A I T L E R W H T I T H A M Q L D C K V Q L R H A A S V M V M G W I F A F A A A L F P I F G I S S Y M K V S I C L P M D I D S P L S Q L Y V M S L L V L N V L A F V V I C G C Y I H I Y L T V R N P N I V S S S S D T R I A K R M A M L I F T D F L C M A P I S F F A I S A S L K V P L I T V S K A K I L L V L F H P I N S C A N P F L Y A I F T K N F R R D F F I L L S K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I2G	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	Glycoprotein hormones α chain	Compound 716340	Gs/β1/γ2	2.8	2023-03-29	doi.org/10.1038/s41467-023-36170-3
	8I2G (No Gprot)	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	Glycoprotein hormones α chain	Compound 716340		2.8	2023-03-29	doi.org/10.1038/s41467-023-36170-3
	8I2H	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	-	-	-	6	2023-03-22	doi.org/10.1038/s41467-023-36170-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8I2H.zip

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