psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C31	L:L:C7	7.28	No	No	0	0	0
2	L:L:C10	L:L:C60	7.28	No	No	0	0	0
3	L:L:C10	L:L:C84	5.46	No	No	0	0	0
4	L:L:Q13	L:L:T11	9.92	No	No	0	0	0
5	L:L:L12	L:L:L26	12.46	No	No	0	0	0
6	L:L:M29	L:L:Q13	5.44	Yes	No	0	0	0
7	L:L:F18	L:L:N15	6.04	No	No	0	0	0
8	L:L:N15	L:L:S19	11.92	No	No	0	0	0
9	L:L:N15	R:R:Y335	6.98	No	Yes	0	0	4
10	L:L:P16	R:R:Y335	11.13	No	Yes	0	0	4
11	L:L:F18	L:L:L17	18.27	No	No	0	0	0
12	L:L:L17	R:R:Y335	4.69	No	Yes	0	0	4
13	L:L:F18	R:R:I291	5.02	No	Yes	0	0	2
14	L:L:I25	L:L:S19	6.19	No	No	0	0	0
15	L:L:P21	L:L:Q20	14.21	No	No	0	0	0
16	L:L:A23	L:L:Q20	3.03	No	No	0	0	0
17	L:L:I25	L:L:V76	4.61	No	No	0	0	0
18	L:L:M29	L:L:Q27	8.16	Yes	Yes	7	0	0
19	L:L:Q27	M:M:R35	4.67	Yes	Yes	7	0	0
20	L:L:Q27	M:M:V38	10.03	Yes	No	0	0	0
21	L:L:Q27	R:R:Y335	7.89	Yes	Yes	7	0	4
22	L:L:C28	L:L:C60	3.64	Yes	No	0	0	0
23	L:L:C28	L:L:H79	5.9	Yes	Yes	16	0	0
24	L:L:C28	L:L:C82	7.28	Yes	No	0	0	0
25	L:L:C28	M:M:D36	3.11	Yes	No	16	0	0
26	L:L:M29	M:M:Y33	5.99	Yes	Yes	7	0	0
27	L:L:M29	M:M:R35	11.17	Yes	Yes	7	0	0
28	L:L:C32	L:L:T58	5.07	No	No	15	0	0
29	L:L:C32	L:L:C84	7.28	No	No	15	0	0
30	L:L:F33	L:L:R35	7.48	No	Yes	0	0	0
31	L:L:F33	M:M:Y31	10.32	No	No	0	0	0
32	L:L:S34	M:M:T50	6.4	No	Yes	0	0	0
33	L:L:R35	L:L:Y37	13.38	Yes	Yes	8	0	0
34	L:L:E56	L:L:R35	16.28	Yes	Yes	8	0	0
35	L:L:R35	M:M:P101	5.76	Yes	No	8	0	0
36	L:L:P38	L:L:Y37	4.17	No	Yes	0	0	0
37	L:L:T54	L:L:Y37	14.98	No	Yes	0	0	0
38	L:L:E56	L:L:Y37	10.1	Yes	Yes	8	0	0
39	L:L:Y37	M:M:G100	5.79	Yes	No	8	0	0
40	L:L:Y37	M:M:P101	20.86	Yes	No	8	0	0
41	L:L:P38	M:M:W27	13.51	No	Yes	0	0	0
42	L:L:K44	L:L:T39	7.51	No	No	0	0	0
43	L:L:T39	L:L:T54	4.71	No	No	0	0	0
44	L:L:L41	M:M:E13	5.3	No	No	0	0	0
45	L:L:L41	M:M:Y74	3.52	No	No	0	0	0
46	L:L:R42	M:M:L99	14.58	No	No	0	0	0
47	L:L:R42	M:M:Y103	26.75	No	No	0	0	0
48	L:L:S43	R:R:Q79	5.78	No	Yes	0	0	7
49	L:L:K44	L:L:Q50	8.14	No	No	0	0	0
50	L:L:T46	R:R:Q79	5.67	No	Yes	2	0	7
51	L:L:T46	R:R:D81	4.34	No	No	0	0	7
52	L:L:T46	R:R:K104	4.5	No	Yes	2	0	6
53	L:L:M47	R:R:K104	5.76	No	Yes	0	0	6
54	L:L:L48	R:R:N106	4.12	No	No	0	0	6
55	L:L:K51	L:L:V49	4.55	No	No	0	0	0
56	L:L:K51	R:R:D153	6.91	No	No	0	0	6
57	L:L:V53	M:M:W27	7.36	No	Yes	0	0	0
58	L:L:V53	M:M:T92	3.17	No	No	0	0	0
59	L:L:S55	M:M:T50	4.8	No	Yes	0	0	0
60	L:L:E56	M:M:R97	3.49	Yes	No	0	0	0
61	L:L:C87	L:L:S57	6.89	Yes	No	2	0	0
62	L:L:H90	L:L:S57	5.58	Yes	No	2	0	0
63	L:L:S57	M:M:T50	3.2	No	Yes	0	0	0
64	L:L:C84	L:L:T58	3.38	No	No	15	0	0
65	L:L:C59	L:L:C87	7.28	No	Yes	2	0	0
66	L:L:C59	M:M:T34	3.38	No	No	0	0	0
67	L:L:C59	M:M:Q48	13.74	No	Yes	2	0	0
68	L:L:V61	M:M:D36	5.84	No	No	0	0	0
69	L:L:A62	L:L:H79	4.39	No	Yes	0	0	0
70	L:L:A81	L:L:K63	3.21	No	No	0	0	0
71	L:L:H83	L:L:K63	10.48	No	No	0	0	0
72	L:L:S64	L:L:T80	4.8	No	No	0	0	0
73	L:L:A81	L:L:S64	3.42	No	No	0	0	0
74	L:L:E77	L:L:Y65	30.3	No	No	0	0	0
75	L:L:N66	L:L:T80	4.39	No	No	0	0	0
76	L:L:E77	L:L:R67	9.3	No	No	0	0	0
77	L:L:M71	L:L:V70	10.65	No	No	0	0	0
78	L:L:M71	R:R:I291	7.29	No	Yes	0	0	2
79	L:L:F74	M:M:Y39	3.09	No	No	0	0	0
80	L:L:F74	R:R:H289	3.39	No	Yes	0	0	3
81	L:L:F74	R:R:I291	10.05	No	Yes	0	0	2
82	L:L:E77	M:M:K40	9.45	No	No	0	0	0
83	L:L:N78	L:L:T80	4.39	No	No	0	0	0
84	L:L:H79	M:M:D36	10.08	Yes	No	16	0	0
85	L:L:H79	M:M:V38	4.15	Yes	No	0	0	0
86	L:L:H83	L:L:S85	6.97	No	No	0	0	0
87	L:L:S85	L:L:T86	3.2	No	No	0	0	0
88	L:L:T86	L:L:Y88	4.99	No	No	0	0	0
89	L:L:C87	L:L:H90	7.37	Yes	Yes	2	0	0
90	L:L:C87	M:M:Q48	4.58	Yes	Yes	2	0	0
91	L:L:Y88	L:L:Y89	5.96	No	No	0	0	0
92	L:L:Y88	R:R:Y124	25.81	No	Yes	0	0	6
93	L:L:Y89	M:M:K46	16.72	No	No	0	0	0
94	L:L:Y89	M:M:Q48	3.38	No	Yes	0	0	0
95	L:L:H90	L:L:K91	3.93	Yes	Yes	2	0	0
96	L:L:H90	M:M:Q48	4.95	Yes	Yes	2	0	0
97	L:L:H90	M:M:C87	4.42	Yes	No	2	0	0
98	L:L:H90	M:M:C94	7.37	Yes	No	2	0	0
99	L:L:K91	M:M:S89	6.12	Yes	No	0	0	0
100	L:L:K91	M:M:C94	3.23	Yes	No	2	0	0
101	L:L:K91	R:R:Q152	5.42	Yes	Yes	2	0	7
102	L:L:S92	M:M:S89	4.89	No	No	0	0	0
103	M:M:C32	M:M:N1	12.6	No	No	5	0	0
104	M:M:C84	M:M:N1	9.45	No	No	5	0	0
105	M:M:C3	M:M:G30	3.92	No	No	0	0	0
106	M:M:C3	M:M:C51	7.28	No	Yes	5	0	0
107	M:M:L5	M:M:T26	8.84	No	No	0	0	0
108	M:M:C82	M:M:L5	4.76	No	No	0	0	0
109	M:M:I8	M:M:T25	3.04	No	Yes	0	0	0
110	M:M:I8	M:M:W27	7.05	No	Yes	0	0	0
111	M:M:I10	M:M:I12	2.94	No	No	0	0	0
112	M:M:I10	M:M:T25	3.04	No	Yes	11	0	0
113	M:M:I10	M:M:Y76	6.04	No	Yes	11	0	0
114	M:M:I12	M:M:Y74	10.88	No	No	0	0	0
115	M:M:E13	M:M:S105	4.31	No	No	17	0	0
116	M:M:E13	M:M:F106	3.5	No	Yes	17	0	0
117	M:M:F19	M:M:K14	6.2	Yes	No	12	0	0
118	M:M:K14	M:M:V63	10.62	No	No	12	0	0
119	M:M:K14	M:M:S72	4.59	No	No	0	0	0
120	M:M:E15	M:M:E16	8.88	No	No	0	0	0
121	M:M:E16	M:M:H69	17.23	No	No	0	0	0
122	M:M:C17	M:M:C66	7.28	No	No	0	0	0
123	M:M:F106	M:M:R18	9.62	Yes	No	0	0	0
124	M:M:F19	M:M:V63	3.93	Yes	No	12	0	0
125	M:M:F19	M:M:P64	4.33	Yes	No	12	0	0
126	M:M:C104	M:M:C20	7.28	No	No	0	0	0
127	M:M:I21	M:M:I23	2.94	No	No	0	0	0
128	M:M:I23	M:M:V61	3.07	No	No	0	0	0
129	M:M:T25	M:M:T26	3.14	Yes	No	0	0	0
130	M:M:T25	M:M:Y76	3.75	Yes	Yes	11	0	0
131	M:M:T25	M:M:V78	6.35	Yes	No	11	0	0
132	M:M:A79	M:M:W27	3.89	No	Yes	0	0	0
133	M:M:C28	M:M:C82	7.28	No	No	0	0	0
134	M:M:C32	M:M:C84	5.46	No	No	5	0	0
135	M:M:R35	M:M:Y33	8.23	Yes	Yes	7	0	0
136	M:M:I47	M:M:R35	5.01	No	Yes	0	0	0
137	M:M:R35	R:R:Y335	3.09	Yes	Yes	7	0	4
138	M:M:L37	M:M:R44	10.93	No	Yes	0	0	0
139	M:M:I47	M:M:L37	4.28	No	No	0	0	0
140	M:M:D41	M:M:Y39	11.49	No	No	0	0	0
141	M:M:K40	M:M:R44	4.95	No	Yes	0	0	0
142	M:M:D41	M:M:P42	6.44	No	No	0	0	0
143	M:M:P42	R:R:D196	3.22	No	No	0	0	4
144	M:M:P42	R:R:V221	7.07	No	No	0	0	1
145	M:M:A43	R:R:K243	4.82	No	No	0	0	5
146	M:M:K46	M:M:R44	12.38	No	Yes	0	0	0
147	M:M:K49	M:M:K86	5.75	No	No	0	0	0
148	M:M:F53	M:M:L56	6.09	No	No	0	0	0
149	M:M:F53	M:M:S91	5.28	No	No	18	0	0
150	M:M:F53	M:M:T92	3.89	No	No	18	0	0
151	M:M:E55	M:M:K54	13.5	No	No	0	0	0
152	M:M:K54	M:M:Q81	16.27	No	No	0	0	0
153	M:M:E55	M:M:T80	4.23	No	No	0	0	0
154	M:M:L56	M:M:P77	4.93	No	No	0	0	0
155	M:M:T80	M:M:V57	4.76	No	No	0	0	0
156	M:M:T75	M:M:Y58	8.74	No	No	0	0	0
157	M:M:E59	M:M:V61	4.28	No	No	0	0	0
158	M:M:E59	M:M:Y76	6.73	No	Yes	0	0	0
159	M:M:L73	M:M:T60	4.42	No	No	0	0	0
160	M:M:T60	M:M:T75	7.85	No	No	0	0	0
161	M:M:D71	M:M:R62	16.68	No	No	0	0	0
162	M:M:L73	M:M:R62	8.5	No	No	0	0	0
163	M:M:P64	M:M:V63	3.53	No	No	12	0	0
164	M:M:A70	M:M:D71	3.09	No	No	0	0	0
165	M:M:P77	M:M:Y76	4.17	No	Yes	0	0	0
166	M:M:V78	M:M:Y76	5.05	No	Yes	11	0	0
167	M:M:G85	M:M:H83	3.18	No	No	0	0	0
168	M:M:C87	M:M:C94	7.28	No	No	2	0	0
169	M:M:D88	M:M:D90	7.98	No	No	0	0	0
170	M:M:D88	M:M:S91	7.36	No	No	0	0	0
171	M:M:S89	R:R:K179	6.12	No	Yes	0	0	6
172	M:M:S91	M:M:T92	3.2	No	No	18	0	0
173	M:M:D93	M:M:T95	5.78	Yes	Yes	2	0	0
174	M:M:D93	R:R:E103	3.9	Yes	Yes	2	0	5
175	M:M:D93	R:R:K104	9.68	Yes	Yes	2	0	6
176	M:M:T95	R:R:E103	8.47	Yes	Yes	2	0	5
177	M:M:T95	R:R:K104	6.01	Yes	Yes	2	0	6
178	M:M:L99	R:R:Q33	3.99	No	No	0	0	4
179	M:M:G100	M:M:P101	4.06	No	No	8	0	0
180	M:M:F106	M:M:S105	10.57	Yes	No	17	0	0
181	R:R:C18	R:R:C25	7.28	No	No	1	8	8
182	R:R:C18	R:R:F30	4.19	No	Yes	1	8	5
183	R:R:C23	R:R:H20	8.85	No	Yes	0	8	7
184	R:R:H20	R:R:P41	6.1	Yes	Yes	1	7	9
185	R:R:D43	R:R:H20	13.87	No	Yes	1	5	7
186	R:R:H20	R:R:L44	15.43	Yes	Yes	1	7	2
187	R:R:I22	R:R:R21	8.77	Yes	No	0	4	1
188	R:R:D43	R:R:R21	9.53	No	No	0	5	1
189	R:R:I22	R:R:V37	7.68	Yes	Yes	1	4	6
190	R:R:I22	R:R:P41	3.39	Yes	Yes	1	4	9
191	R:R:C23	R:R:C32	7.28	No	No	0	8	9
192	R:R:E34	R:R:H24	9.85	No	No	0	2	2
193	R:R:C25	R:R:F30	12.57	No	Yes	1	8	5
194	R:R:N27	R:R:S26	2.98	No	No	0	1	4
195	R:R:N47	R:R:R28	8.44	No	No	0	5	1
196	R:R:I49	R:R:R28	11.27	No	No	0	3	1
197	R:R:D71	R:R:R28	4.76	No	No	0	4	1
198	R:R:I49	R:R:V29	3.07	No	No	0	3	5
199	R:R:E50	R:R:V29	8.56	No	No	0	4	5
200	R:R:F30	R:R:L44	4.87	Yes	Yes	1	5	2
201	R:R:F30	R:R:P45	10.11	Yes	No	1	5	2
202	R:R:A48	R:R:F30	4.16	No	Yes	1	3	5
203	R:R:F30	R:R:L51	3.65	Yes	Yes	1	5	8
204	R:R:L31	R:R:Q33	5.32	No	No	0	4	4
205	R:R:L31	R:R:R52	3.64	No	No	0	4	5
206	R:R:L31	R:R:V54	2.98	No	No	0	4	2
207	R:R:P41	R:R:V37	3.53	Yes	Yes	1	9	6
208	R:R:T56	R:R:V37	3.17	No	Yes	0	6	6
209	R:R:I40	R:R:P41	3.39	Yes	Yes	1	5	9
210	R:R:I40	R:R:L58	4.28	Yes	No	1	5	3
211	R:R:I40	R:R:I61	4.42	Yes	Yes	1	5	8
212	R:R:A65	R:R:I40	6.5	No	Yes	1	5	5
213	R:R:F66	R:R:I40	3.77	Yes	Yes	1	8	5
214	R:R:D43	R:R:P41	4.83	No	Yes	1	5	9
215	R:R:L44	R:R:P41	8.21	Yes	Yes	1	2	9
216	R:R:L44	R:R:P45	3.28	Yes	No	1	2	2
217	R:R:N47	R:R:P45	4.89	No	No	0	5	2
218	R:R:G68	R:R:R46	4.5	No	No	0	4	1
219	R:R:F69	R:R:R46	6.41	No	No	0	6	1
220	R:R:A48	R:R:L51	3.15	No	Yes	1	3	8
221	R:R:E73	R:R:I49	5.47	No	No	0	2	3
222	R:R:E50	R:R:R52	17.45	No	No	0	4	5
223	R:R:E50	R:R:K74	18.9	No	No	0	4	3
224	R:R:F53	R:R:L51	8.53	No	Yes	0	6	8
225	R:R:L51	R:R:L72	8.3	Yes	Yes	0	8	7
226	R:R:E76	R:R:R52	16.28	No	No	0	5	5
227	R:R:F53	R:R:F66	9.65	No	Yes	0	6	8
228	R:R:F53	R:R:I77	5.02	No	No	0	6	8
229	R:R:E76	R:R:V54	5.7	No	No	2	5	2
230	R:R:S78	R:R:V54	4.85	No	No	2	5	2
231	R:R:L55	R:R:Q79	3.99	No	Yes	0	4	7
232	R:R:L58	R:R:T56	4.42	No	No	0	3	6
233	R:R:N80	R:R:T56	7.31	No	No	0	7	6
234	R:R:K57	R:R:V82	9.11	No	No	0	3	5
235	R:R:I61	R:R:L58	5.71	Yes	No	1	8	3
236	R:R:E84	R:R:V60	4.28	No	Yes	19	4	4
237	R:R:V60	R:R:V85	4.81	Yes	No	19	4	4
238	R:R:E87	R:R:V60	4.28	No	Yes	0	6	4
239	R:R:I61	R:R:L83	4.28	Yes	No	0	8	8
240	R:R:I61	R:R:I86	10.3	Yes	Yes	1	8	8
241	R:R:I61	R:R:V90	4.61	Yes	Yes	1	8	9
242	R:R:A65	R:R:Q62	3.03	No	No	0	5	4
243	R:R:E87	R:R:K63	6.75	No	No	0	6	5
244	R:R:D89	R:R:G64	3.35	No	No	0	3	4
245	R:R:A65	R:R:F66	5.55	No	Yes	1	5	8
246	R:R:F66	R:R:I75	5.02	Yes	Yes	1	8	7
247	R:R:F66	R:R:V90	5.24	Yes	Yes	1	8	9
248	R:R:F66	R:R:F91	4.29	Yes	Yes	1	8	9
249	R:R:S67	R:R:S92	6.52	No	No	0	1	4
250	R:R:F69	R:R:L72	4.87	No	Yes	0	6	7
251	R:R:I75	R:R:L72	7.14	Yes	Yes	0	7	7
252	R:R:L72	R:R:L94	4.15	Yes	No	0	7	8
253	R:R:H98	R:R:K74	6.55	No	No	2	4	3
254	R:R:E99	R:R:K74	9.45	Yes	No	2	6	3
255	R:R:I75	R:R:L97	8.56	Yes	Yes	1	7	8
256	R:R:I100	R:R:I75	2.94	Yes	Yes	1	8	7
257	R:R:E76	R:R:S78	5.75	No	No	2	5	5
258	R:R:I102	R:R:I77	4.42	No	No	0	8	8
259	R:R:Q79	R:R:S78	4.33	Yes	No	2	7	5
260	R:R:K104	R:R:Q79	13.56	Yes	Yes	2	6	7
261	R:R:D81	R:R:V82	7.3	No	No	0	7	5
262	R:R:L108	R:R:L83	5.54	Yes	No	0	9	8
263	R:R:E84	R:R:V85	9.98	No	No	19	4	4
264	R:R:I86	R:R:V90	4.61	Yes	Yes	1	8	9
265	R:R:I102	R:R:I86	2.94	No	Yes	0	8	8
266	R:R:I86	R:R:L108	5.71	Yes	Yes	1	8	9
267	R:R:I111	R:R:I86	7.36	No	Yes	1	9	8
268	R:R:A88	R:R:N112	3.13	No	Yes	0	5	5
269	R:R:D89	R:R:Q117	5.22	No	No	0	3	5
270	R:R:F91	R:R:V90	9.18	Yes	Yes	1	9	9
271	R:R:F91	R:R:I100	3.77	Yes	Yes	1	9	8
272	R:R:F116	R:R:F91	13.93	Yes	Yes	1	9	9
273	R:R:L94	R:R:S92	6.01	No	No	0	8	4
274	R:R:N93	R:R:Q117	6.6	No	No	0	6	5
275	R:R:L94	R:R:L97	4.15	No	Yes	0	8	8
276	R:R:I100	R:R:L97	7.14	Yes	Yes	1	8	8
277	R:R:E99	R:R:H98	4.92	Yes	No	2	6	4
278	R:R:H98	R:R:Q123	6.18	No	No	2	4	5
279	R:R:E99	R:R:R101	6.98	Yes	Yes	2	6	5
280	R:R:E99	R:R:Y124	6.73	Yes	Yes	2	6	6
281	R:R:I100	R:R:L122	4.28	Yes	Yes	1	8	9
282	R:R:E103	R:R:R101	5.82	Yes	Yes	2	5	5
283	R:R:R101	R:R:Y124	9.26	Yes	Yes	2	5	6
284	R:R:L126	R:R:R101	18.22	Yes	Yes	2	7	5
285	R:R:I102	R:R:I127	10.3	No	Yes	0	8	9
286	R:R:E103	R:R:K104	18.9	Yes	Yes	2	5	6
287	R:R:K104	R:R:N129	4.2	Yes	No	0	6	8
288	R:R:A105	R:R:L108	4.73	No	Yes	0	8	9
289	R:R:A105	R:R:T130	3.36	No	Yes	0	8	8
290	R:R:N106	R:R:N107	14.98	No	No	0	6	5
291	R:R:I111	R:R:L108	5.71	No	Yes	1	9	9
292	R:R:N112	R:R:Y110	4.65	Yes	No	1	5	1
293	R:R:P113	R:R:Y110	5.56	No	No	1	4	1
294	R:R:I111	R:R:I132	2.94	No	Yes	1	9	7
295	R:R:N112	R:R:P113	3.26	Yes	No	1	5	4
296	R:R:D137	R:R:P113	9.66	No	No	0	7	4
297	R:R:E114	R:R:K140	10.8	No	No	0	6	5
298	R:R:F116	R:R:P136	4.33	Yes	No	1	9	9
299	R:R:F116	R:R:I141	3.77	Yes	Yes	1	9	8
300	R:R:N118	R:R:P120	6.52	No	No	0	6	8
301	R:R:H142	R:R:N118	6.38	No	No	0	4	6
302	R:R:L144	R:R:P120	3.28	No	No	0	6	8
303	R:R:N121	R:R:Q123	6.6	No	No	2	4	5
304	R:R:N121	R:R:Q145	3.96	No	No	2	4	5
305	R:R:I141	R:R:L122	4.28	Yes	Yes	1	8	9
306	R:R:L122	R:R:S143	4.5	Yes	No	1	9	8
307	R:R:L122	R:R:V147	2.98	Yes	Yes	1	9	6
308	R:R:Q123	R:R:Q145	8.96	No	No	2	5	5
309	R:R:L126	R:R:Y124	8.21	Yes	Yes	2	7	6
310	R:R:L148	R:R:Y124	3.52	No	Yes	2	5	6
311	R:R:L126	R:R:S128	7.51	Yes	No	2	7	7
312	R:R:D150	R:R:L126	9.5	Yes	Yes	2	7	7
313	R:R:I127	R:R:T130	4.56	Yes	Yes	1	9	8
314	R:R:I127	R:R:I132	4.42	Yes	Yes	1	9	7
315	R:R:I127	R:R:P136	3.39	Yes	No	1	9	9
316	R:R:I127	R:R:I151	4.42	Yes	Yes	1	9	7
317	R:R:D150	R:R:S128	5.89	Yes	No	2	7	7
318	R:R:Q152	R:R:S128	5.78	Yes	No	2	7	7
319	R:R:I132	R:R:T130	7.6	Yes	Yes	1	7	8
320	R:R:N154	R:R:T130	5.85	No	Yes	1	9	8
321	R:R:G131	R:R:N156	3.39	Yes	No	0	5	4
322	R:R:I132	R:R:N154	5.66	Yes	No	1	7	9
323	R:R:I132	R:R:I157	4.42	Yes	No	1	7	7
324	R:R:H134	R:R:K133	3.93	No	No	0	3	4
325	R:R:I151	R:R:L135	4.28	Yes	No	0	7	7
326	R:R:I160	R:R:L135	4.28	Yes	No	0	6	7
327	R:R:I151	R:R:P136	3.39	Yes	No	1	7	9
328	R:R:D137	R:R:H139	6.3	No	No	0	7	6
329	R:R:I141	R:R:V138	3.07	Yes	No	1	8	7
330	R:R:L168	R:R:V138	5.96	Yes	No	1	5	7
331	R:R:H139	R:R:K140	9.17	No	No	0	6	5
332	R:R:I141	R:R:L168	5.71	Yes	Yes	1	8	5
333	R:R:G167	R:R:H142	3.18	No	No	0	5	4
334	R:R:F170	R:R:H142	4.53	No	No	0	3	4
335	R:R:S143	R:R:V147	3.23	No	Yes	1	8	6
336	R:R:S143	R:R:S169	4.89	No	No	1	8	4
337	R:R:K146	R:R:S172	7.65	No	No	0	6	5
338	R:R:L168	R:R:V147	5.96	Yes	Yes	1	5	6
339	R:R:S169	R:R:V147	4.85	No	Yes	1	4	6
340	R:R:I174	R:R:L148	8.56	Yes	No	2	5	5
341	R:R:L148	R:R:W176	10.25	No	Yes	2	5	6
342	R:R:I151	R:R:L149	4.28	Yes	Yes	1	7	8
343	R:R:F165	R:R:L149	7.31	Yes	Yes	1	7	8
344	R:R:L149	R:R:L175	5.54	Yes	Yes	1	8	7
345	R:R:L149	R:R:L177	5.54	Yes	Yes	1	8	9
346	R:R:D150	R:R:Q152	14.36	Yes	Yes	2	7	7
347	R:R:D150	R:R:W176	10.05	Yes	Yes	2	7	6
348	R:R:I151	R:R:L177	4.28	Yes	Yes	1	7	9
349	R:R:Q152	R:R:W176	4.38	Yes	Yes	2	7	6
350	R:R:N178	R:R:Q152	13.2	Yes	Yes	2	5	7
351	R:R:K179	R:R:Q152	4.07	Yes	Yes	2	6	7
352	R:R:D153	R:R:K179	6.91	No	Yes	0	6	6
353	R:R:I157	R:R:N154	4.25	No	No	1	7	9
354	R:R:I155	R:R:N156	4.25	No	No	0	5	4
355	R:R:H158	R:R:Q183	8.65	No	No	0	3	1
356	R:R:I160	R:R:S164	7.74	Yes	No	1	6	6
357	R:R:F165	R:R:I160	3.77	Yes	Yes	1	7	6
358	R:R:I160	R:R:I185	5.89	Yes	No	0	6	7
359	R:R:A189	R:R:I160	3.25	No	Yes	0	8	6
360	R:R:N163	R:R:R162	6.03	No	No	0	7	4
361	R:R:N163	R:R:V166	5.91	No	No	0	7	1
362	R:R:N163	R:R:N191	4.09	No	Yes	0	7	5
363	R:R:F165	R:R:S164	3.96	Yes	No	1	7	6
364	R:R:F165	R:R:L175	8.53	Yes	Yes	1	7	7
365	R:R:F165	R:R:L177	4.87	Yes	Yes	1	7	9
366	R:R:F165	R:R:F190	4.29	Yes	Yes	0	7	9
367	R:R:L168	R:R:V173	7.45	Yes	No	0	5	4
368	R:R:D196	R:R:S172	8.83	No	No	0	4	5
369	R:R:L175	R:R:V173	2.98	Yes	No	0	7	4
370	R:R:I174	R:R:W176	7.05	Yes	Yes	2	5	6
371	R:R:D196	R:R:I174	4.2	No	Yes	0	4	5
372	R:R:E197	R:R:I174	6.83	No	Yes	2	5	5
373	R:R:L175	R:R:L177	4.15	Yes	Yes	1	7	9
374	R:R:L175	R:R:L195	4.15	Yes	No	0	7	9
375	R:R:E197	R:R:W176	5.45	No	Yes	2	5	6
376	R:R:K179	R:R:N178	8.39	Yes	Yes	2	6	5
377	R:R:N178	R:R:N199	14.98	Yes	No	2	5	5
378	R:R:N178	R:R:S201	7.45	Yes	Yes	2	5	7
379	R:R:D202	R:R:K179	12.44	No	Yes	0	5	6
380	R:R:I182	R:R:N180	4.25	No	No	20	8	9
381	R:R:N180	R:R:N203	4.09	No	No	20	9	9
382	R:R:I182	R:R:N203	9.91	No	No	20	8	9
383	R:R:E184	R:R:H186	7.39	No	No	0	4	1
384	R:R:I185	R:R:L206	5.71	No	Yes	0	7	8
385	R:R:I185	R:R:V213	3.07	No	Yes	0	7	8
386	R:R:N187	R:R:P210	8.15	No	No	0	4	6
387	R:R:D212	R:R:N187	6.73	No	No	0	4	4
388	R:R:C188	R:R:N191	4.72	No	Yes	0	4	5
389	R:R:C188	R:R:H215	4.42	No	No	0	4	2
390	R:R:A189	R:R:F190	4.16	No	Yes	0	8	9
391	R:R:F190	R:R:L195	4.87	Yes	No	0	9	9
392	R:R:F190	R:R:L198	10.96	Yes	Yes	0	9	7
393	R:R:F190	R:R:F214	3.22	Yes	Yes	0	9	9
394	R:R:G192	R:R:N191	5.09	No	Yes	0	5	5
395	R:R:G216	R:R:N191	3.39	No	Yes	0	4	5
396	R:R:L195	R:R:T193	2.95	No	No	0	9	5
397	R:R:E197	R:R:I222	8.2	No	No	0	5	3
398	R:R:L198	R:R:L200	8.3	Yes	No	0	7	9
399	R:R:L198	R:R:P220	3.28	Yes	Yes	9	7	8
400	R:R:L198	R:R:L223	4.15	Yes	Yes	9	7	8
401	R:R:N199	R:R:S201	7.45	No	Yes	2	5	7
402	R:R:D224	R:R:N199	14.81	No	No	2	9	5
403	R:R:L200	R:R:N203	4.12	No	No	0	9	9
404	R:R:D202	R:R:S201	8.83	No	Yes	0	5	7
405	R:R:D224	R:R:S201	8.83	No	Yes	2	9	7
406	R:R:D202	R:R:R227	9.53	No	No	0	5	7
407	R:R:L206	R:R:L209	4.15	Yes	Yes	13	8	7
408	R:R:L206	R:R:T228	4.42	Yes	No	13	8	9
409	R:R:I230	R:R:L206	4.28	Yes	Yes	13	8	8
410	R:R:E207	R:R:E208	3.81	No	No	0	1	1
411	R:R:E207	R:R:R229	10.47	No	No	0	1	4
412	R:R:E207	R:R:H231	4.92	No	No	0	1	4
413	R:R:L209	R:R:V213	2.98	Yes	Yes	0	7	8
414	R:R:I230	R:R:L209	5.71	Yes	Yes	13	8	7
415	R:R:L209	R:R:P234	6.57	Yes	No	0	7	9
416	R:R:P210	R:R:V213	5.3	No	Yes	0	6	8
417	R:R:D212	R:R:Y236	6.9	No	No	0	4	2
418	R:R:F214	R:R:V213	7.87	Yes	Yes	0	9	8
419	R:R:F214	R:R:P220	11.56	Yes	Yes	0	9	8
420	R:R:F214	R:R:P234	7.22	Yes	No	0	9	9
421	R:R:F214	R:R:L238	3.65	Yes	No	0	9	8
422	R:R:G216	R:R:H215	3.18	No	No	0	4	2
423	R:R:H215	R:R:Y236	7.62	No	No	0	2	2
424	R:R:G219	R:R:P220	4.06	No	Yes	0	6	8
425	R:R:G219	R:R:N240	5.09	No	No	0	6	4
426	R:R:L223	R:R:P220	3.28	Yes	Yes	9	8	8
427	R:R:I222	R:R:V221	6.14	No	No	0	3	1
428	R:R:I222	R:R:K243	7.27	No	No	0	3	5
429	R:R:L223	R:R:L244	4.15	Yes	No	9	8	9
430	R:R:D224	R:R:R245	5.96	No	No	0	9	4
431	R:R:I225	R:R:I230	4.42	No	Yes	0	8	8
432	R:R:A246	R:R:I225	3.25	No	No	0	8	8
433	R:R:R227	R:R:S226	11.86	No	No	0	7	8
434	R:R:I230	R:R:T228	4.56	Yes	No	13	8	9
435	R:R:N251	R:R:R229	4.82	No	No	0	5	4
436	R:R:H231	R:R:N251	7.65	No	No	0	4	5
437	R:R:L233	R:R:P234	4.93	No	No	0	8	9
438	R:R:L233	R:R:L238	4.15	No	No	0	8	8
439	R:R:L233	R:R:P256	4.93	No	No	0	8	7
440	R:R:K260	R:R:S235	3.06	No	No	0	4	4
441	R:R:E239	R:R:G237	4.91	No	No	0	3	8
442	R:R:E239	R:R:N240	6.57	No	No	0	3	4
443	R:R:K242	R:R:M265	7.2	No	No	0	6	5
444	R:R:E266	R:R:K243	8.1	No	No	0	4	5
445	R:R:A267	R:R:L244	3.15	No	No	0	8	9
446	R:R:A246	R:R:T249	5.03	No	No	0	8	7
447	R:R:R247	R:R:S268	5.27	No	No	0	4	5
448	R:R:L252	R:R:T249	5.9	No	No	0	8	7
449	R:R:T249	R:R:T270	6.28	No	No	0	7	8
450	R:R:Y250	R:R:Y271	5.96	No	Yes	0	3	9
451	R:R:I434	R:R:K253	7.27	No	No	0	7	6
452	R:R:K254	R:R:N431	6.99	No	Yes	0	3	5
453	R:R:L255	R:R:P256	4.93	No	No	0	6	7
454	R:R:L255	R:R:L269	4.15	No	No	0	6	7
455	R:R:H274	R:R:L255	6.43	No	No	0	9	6
456	R:R:K260	R:R:T257	6.01	No	No	0	4	4
457	R:R:F278	R:R:L264	7.31	Yes	No	0	8	6
458	R:R:M265	R:R:V341	3.04	No	No	0	5	3
459	R:R:T270	R:R:Y271	8.74	No	Yes	0	8	9
460	R:R:H274	R:R:Y271	5.44	No	Yes	0	9	9
461	R:R:I434	R:R:Y271	18.13	No	Yes	0	7	9
462	R:R:D351	R:R:P272	9.66	No	No	0	8	7
463	R:R:I273	R:R:N354	4.25	Yes	No	0	8	8
464	R:R:A433	R:R:I273	3.25	No	Yes	0	9	8
465	R:R:I273	R:R:I434	2.94	Yes	No	0	8	7
466	R:R:C275	R:R:C346	7.28	No	No	0	9	9
467	R:R:C276	R:R:P350	5.65	No	No	0	9	8
468	R:R:C276	R:R:C356	7.28	No	No	0	9	9
469	R:R:A277	R:R:H430	7.32	No	No	0	8	7
470	R:R:F278	R:R:V344	6.55	Yes	No	0	8	5
471	R:R:A279	R:R:N280	3.13	No	No	0	3	5
472	R:R:N280	R:R:R282	6.03	No	No	0	5	4
473	R:R:E287	R:R:R283	6.98	No	No	0	2	3
474	R:R:L288	R:R:S286	6.01	No	No	0	1	4
475	R:R:S286	R:R:V342	3.23	No	No	0	4	4
476	R:R:E287	R:R:H289	6.15	No	Yes	0	2	3
477	R:R:C338	R:R:H289	4.42	No	Yes	0	8	3
478	R:R:C292	R:R:D336	3.11	No	No	0	1	3
479	R:R:C292	R:R:L337	4.76	No	No	21	1	1
480	R:R:C292	R:R:C338	7.28	No	No	21	1	8
481	R:R:T329	R:R:Y330	3.75	No	No	0	4	4
482	R:R:T331	R:R:Y330	8.74	No	No	0	4	4
483	R:R:E332	R:R:F333	4.66	No	No	0	5	3
484	R:R:C338	R:R:L337	3.17	No	No	21	8	1
485	R:R:E340	R:R:N339	3.94	No	No	0	3	1
486	R:R:E340	R:R:V342	4.28	No	No	0	3	4
487	R:R:D343	R:R:E340	6.5	No	No	0	4	3
488	R:R:P348	R:R:S347	7.13	No	No	0	9	6
489	R:R:K349	R:R:P350	5.02	No	No	0	3	8
490	R:R:N354	R:R:Q437	3.96	No	No	0	8	9
491	R:R:P355	R:R:V604	7.07	No	No	0	9	8
492	R:R:P355	R:R:S605	5.34	No	No	0	9	7
493	R:R:E357	R:R:G361	6.55	No	No	22	7	8
494	R:R:E357	R:R:Y362	4.49	No	No	22	7	7
495	R:R:E357	R:R:S605	4.31	No	No	0	7	7
496	R:R:D358	R:R:R366	8.34	No	Yes	0	7	9
497	R:R:I359	R:R:V421	3.07	Yes	No	4	8	7
498	R:R:D422	R:R:I359	9.8	No	Yes	0	9	8
499	R:R:I359	R:R:T425	3.04	Yes	No	4	8	9
500	R:R:I359	R:R:Y429	8.46	Yes	Yes	4	8	9
501	R:R:I369	R:R:M360	5.83	Yes	No	3	8	7
502	R:R:D422	R:R:M360	9.7	No	No	0	9	7
503	R:R:M360	R:R:V612	3.04	No	No	3	7	8
504	R:R:G361	R:R:Y362	4.35	No	No	22	8	7
505	R:R:I609	R:R:Y362	7.25	No	No	0	8	7
506	R:R:I364	R:R:L365	4.28	No	No	0	4	8
507	R:R:I609	R:R:L365	12.85	No	No	0	8	8
508	R:R:L365	R:R:V612	4.47	No	No	0	8	8
509	R:R:D422	R:R:R366	14.29	No	Yes	0	9	9
510	R:R:I423	R:R:R366	3.76	No	Yes	0	5	9
511	R:R:K426	R:R:R366	7.43	No	Yes	0	5	9
512	R:R:I372	R:R:L368	4.28	No	No	0	8	6
513	R:R:I369	R:R:L415	5.71	Yes	Yes	0	8	8
514	R:R:I369	R:R:I418	2.94	Yes	No	3	8	8
515	R:R:A419	R:R:I369	6.5	No	Yes	0	9	8
516	R:R:I369	R:R:V612	3.07	Yes	No	3	8	8
517	R:R:L416	R:R:W370	3.42	No	No	0	6	9
518	R:R:A419	R:R:W370	7.78	No	No	0	9	9
519	R:R:I423	R:R:W370	5.87	No	No	0	5	9
520	R:R:I372	R:R:P616	3.39	No	No	0	8	9
521	R:R:L415	R:R:S373	3	Yes	No	0	8	5
522	R:R:L416	R:R:S373	7.51	No	No	0	6	5
523	R:R:C620	R:R:L375	7.94	No	No	0	7	6
524	R:R:A376	R:R:S619	3.42	No	No	0	8	9
525	R:R:I377	R:R:L409	4.28	No	No	0	5	5
526	R:R:G379	R:R:T378	3.64	No	No	0	7	3
527	R:R:A405	R:R:N380	3.13	No	No	0	8	9
528	R:R:D408	R:R:N380	9.42	Yes	No	0	9	9
529	R:R:N380	R:R:P623	9.77	No	No	0	9	9
530	R:R:A627	R:R:V383	5.09	No	No	0	7	9
531	R:R:I628	R:R:V383	3.07	Yes	No	0	7	9
532	R:R:C402	R:R:L384	3.17	No	No	0	7	6
533	R:R:T389	R:R:V385	3.17	No	No	0	4	2
534	R:R:F633	R:R:I386	7.54	Yes	No	0	8	7
535	R:R:D636	R:R:I386	7	Yes	No	10	8	7
536	R:R:I386	R:R:L640	8.56	No	No	10	7	7
537	R:R:L387	R:R:R398	6.07	No	Yes	0	5	8
538	R:R:L387	R:R:M401	4.24	No	No	0	5	8
539	R:R:C402	R:R:L387	3.17	No	No	0	7	5
540	R:R:L640	R:R:T389	5.9	No	No	0	7	4
541	R:R:S390	R:R:Y392	3.82	No	No	0	8	3
542	R:R:R398	R:R:S390	3.95	Yes	No	10	8	8
543	R:R:D636	R:R:S390	8.83	Yes	No	10	8	8
544	R:R:Q391	R:R:Y392	6.76	No	No	0	5	3
545	R:R:I639	R:R:Q391	5.49	No	No	0	4	5
546	R:R:R635	R:R:Y392	21.61	No	No	0	5	3
547	R:R:P397	R:R:T395	6.99	No	No	0	6	7
548	R:R:R398	R:R:T395	3.88	Yes	No	0	8	7
549	R:R:P397	R:R:V396	3.53	No	Yes	23	6	8
550	R:R:L400	R:R:V396	2.98	No	Yes	0	8	8
551	R:R:E466	R:R:V396	4.28	Yes	Yes	23	9	8
552	R:R:A486	R:R:V396	5.09	No	Yes	0	7	8
553	R:R:E466	R:R:P397	9.43	Yes	No	23	9	6
554	R:R:D636	R:R:R398	3.57	Yes	Yes	10	8	8
555	R:R:F399	R:R:N403	10.87	No	No	14	7	8
556	R:R:F399	R:R:M490	6.22	No	No	14	7	7
557	R:R:A462	R:R:L400	3.15	No	No	0	5	8
558	R:R:I463	R:R:L400	7.14	No	No	0	9	8
559	R:R:A627	R:R:M401	3.22	No	No	0	7	8
560	R:R:M490	R:R:N403	12.62	No	No	14	7	8
561	R:R:N403	R:R:W494	5.65	No	Yes	14	8	6
562	R:R:D408	R:R:L404	8.14	Yes	Yes	6	9	8
563	R:R:L404	R:R:S456	3	Yes	No	6	8	9
564	R:R:L404	R:R:T459	4.42	Yes	No	0	8	8
565	R:R:L404	R:R:N622	12.36	Yes	Yes	6	8	9
566	R:R:C410	R:R:F406	4.19	No	No	0	7	5
567	R:R:F406	R:R:W494	6.01	No	Yes	0	5	6
568	R:R:A407	R:R:L455	4.73	No	Yes	0	8	7
569	R:R:D408	R:R:S456	4.42	Yes	No	6	9	9
570	R:R:D408	R:R:S619	8.83	Yes	No	0	9	9
571	R:R:D408	R:R:N622	8.08	Yes	Yes	6	9	9
572	R:R:I413	R:R:L409	7.14	No	No	0	4	5
573	R:R:G412	R:R:I411	3.53	No	Yes	0	9	7
574	R:R:A452	R:R:I411	4.87	No	Yes	0	8	7
575	R:R:I411	R:R:S453	3.1	Yes	No	0	7	8
576	R:R:I411	R:R:S619	6.19	Yes	No	0	7	9
577	R:R:F448	R:R:I413	6.28	No	No	0	8	4
578	R:R:L415	R:R:Y414	3.52	Yes	Yes	0	8	7
579	R:R:I418	R:R:Y414	9.67	No	Yes	3	8	7
580	R:R:T449	R:R:Y414	16.23	No	Yes	0	8	7
581	R:R:I516	R:R:Y414	3.63	Yes	Yes	3	8	7
582	R:R:L611	R:R:Y414	3.52	Yes	Yes	3	7	7
583	R:R:L415	R:R:P616	3.28	Yes	No	0	8	9
584	R:R:L417	R:R:S420	3	No	No	0	5	4
585	R:R:L417	R:R:V421	2.98	No	No	4	5	7
586	R:R:L417	R:R:W436	3.42	No	Yes	4	5	9
587	R:R:I418	R:R:I516	2.94	No	Yes	3	8	8
588	R:R:V421	R:R:W436	6.13	No	Yes	4	7	9
589	R:R:T425	R:R:Y429	4.99	No	Yes	4	9	9
590	R:R:T425	R:R:Y432	7.49	No	No	4	9	5
591	R:R:N431	R:R:Q428	13.2	Yes	No	4	5	5
592	R:R:Q428	R:R:Y432	13.53	No	No	4	5	5
593	R:R:A433	R:R:Y429	8.01	No	Yes	0	9	9
594	R:R:Q437	R:R:Y429	4.51	No	Yes	0	9	9
595	R:R:S515	R:R:Y429	6.36	No	Yes	0	9	9
596	R:R:H430	R:R:N431	8.93	No	Yes	0	7	5
597	R:R:N431	R:R:Y432	3.49	Yes	No	4	5	5
598	R:R:G441	R:R:W436	4.22	No	Yes	0	7	9
599	R:R:C517	R:R:W436	3.92	No	Yes	0	9	9
600	R:R:C442	R:R:C517	7.28	No	No	0	9	9
601	R:R:A445	R:R:C517	3.61	No	No	0	8	9
602	R:R:G446	R:R:Y511	10.14	No	Yes	0	9	8
603	R:R:F447	R:R:F451	4.29	Yes	No	0	8	8
604	R:R:F447	R:R:F498	15	Yes	No	24	8	4
605	R:R:A501	R:R:F447	8.32	No	Yes	0	9	8
606	R:R:F447	R:R:L502	3.65	Yes	No	24	8	3
607	R:R:L518	R:R:T449	2.95	Yes	No	0	8	8
608	R:R:A501	R:R:V450	3.39	No	No	0	9	8
609	R:R:V450	R:R:Y511	6.31	No	Yes	3	8	8
610	R:R:P519	R:R:V450	3.53	Yes	No	3	9	8
611	R:R:F451	R:R:L455	3.65	No	Yes	0	8	7
612	R:R:A497	R:R:F451	4.16	No	No	0	7	8
613	R:R:H615	R:R:S453	8.37	Yes	No	0	6	8
614	R:R:S453	W:W:?1	5.18	No	Yes	0	8	0
615	R:R:E454	R:R:F496	7	No	No	0	8	5
616	R:R:E454	R:R:L534	5.3	No	Yes	0	8	6
617	R:R:E454	R:R:N538	11.83	No	No	0	8	9
618	R:R:L455	R:R:T459	2.95	Yes	No	0	7	8
619	R:R:L455	R:R:W494	10.25	Yes	Yes	0	7	6
620	R:R:N538	R:R:V457	5.91	No	No	0	9	8
621	R:R:V489	R:R:Y458	3.79	No	No	0	5	7
622	R:R:G493	R:R:Y458	5.79	No	No	0	8	7
623	R:R:L460	R:R:N622	4.12	No	Yes	6	9	9
624	R:R:L460	R:R:Y626	5.86	No	Yes	6	9	9
625	R:R:L465	R:R:T461	2.95	No	No	0	5	8
626	R:R:T461	R:R:V544	3.17	No	No	0	8	4
627	R:R:I545	R:R:T461	3.04	No	No	0	8	8
628	R:R:I463	R:R:R467	6.26	No	Yes	0	9	9
629	R:R:I545	R:R:T464	12.16	No	No	0	8	8
630	R:R:C548	R:R:T464	3.38	No	No	0	6	8
631	R:R:T464	R:R:Y549	11.24	No	Yes	0	8	9
632	R:R:E466	R:R:R467	3.49	Yes	Yes	0	9	9
633	R:R:E466	R:R:T470	4.23	Yes	No	0	9	8
634	R:R:R467	R:R:Y549	5.14	Yes	Yes	0	9	9
635	R:R:R467	R:R:Y626	8.23	Yes	Yes	0	9	9
636	R:R:T472	R:R:W468	10.92	No	Yes	0	5	5
637	R:R:C548	R:R:W468	5.22	No	Yes	0	6	5
638	R:R:H551	R:R:W468	8.46	No	Yes	0	4	5
639	R:R:I552	R:R:W468	3.52	No	Yes	0	8	5
640	R:R:H469	R:R:H473	10.75	No	No	0	5	4
641	R:R:C479	R:R:H469	2.95	No	No	0	6	5
642	R:R:I471	R:R:I552	5.89	No	No	25	8	8
643	R:R:H473	R:R:T472	4.11	No	No	0	4	5
644	R:R:H473	R:R:Q476	7.42	No	No	0	4	5
645	R:R:M490	R:R:W494	3.49	No	Yes	14	7	6
646	R:R:F498	R:R:L502	7.31	No	No	24	4	3
647	R:R:A500	R:R:L534	3.15	No	Yes	0	6	6
648	R:R:F503	R:R:I508	7.54	No	No	0	7	6
649	R:R:P504	R:R:Y511	16.69	No	Yes	0	9	8
650	R:R:P504	R:R:Y530	12.52	No	Yes	0	9	7
651	R:R:F506	R:R:I505	3.77	No	No	0	3	7
652	R:R:D521	R:R:S509	4.42	Yes	No	26	8	8
653	R:R:S509	R:R:S527	4.89	No	No	26	8	7
654	R:R:S509	R:R:Y530	5.09	No	Yes	0	8	7
655	R:R:M512	R:R:S510	6.13	No	No	0	5	6
656	R:R:D521	R:R:S510	8.83	Yes	No	0	8	6
657	R:R:P519	R:R:Y511	8.34	Yes	Yes	3	9	8
658	R:R:D523	R:R:K513	4.15	No	No	0	5	5
659	R:R:I516	R:R:V514	3.07	Yes	No	0	8	8
660	R:R:M520	R:R:V514	9.13	No	No	0	8	8
661	R:R:V514	R:R:V604	3.21	No	No	0	8	8
662	R:R:I516	R:R:L518	5.71	Yes	Yes	3	8	8
663	R:R:I516	R:R:K608	4.36	Yes	No	0	8	9
664	R:R:L518	R:R:P519	3.28	Yes	Yes	3	8	9
665	R:R:L518	R:R:M520	4.24	Yes	No	3	8	8
666	R:R:L518	R:R:L611	6.92	Yes	Yes	3	8	7
667	R:R:L518	W:W:?1	15.27	Yes	Yes	3	8	0
668	R:R:P519	W:W:?1	5.66	Yes	Yes	3	9	0
669	R:R:M520	W:W:?1	15.59	No	Yes	3	8	0
670	R:R:D521	R:R:D523	3.99	Yes	No	0	8	5
671	R:R:D521	R:R:S527	2.94	Yes	No	26	8	7
672	R:R:I522	R:R:Q528	5.49	No	No	0	6	6
673	R:R:I522	R:R:S596	4.64	No	Yes	0	6	7
674	R:R:I522	R:R:K598	7.27	No	No	0	6	5
675	R:R:P525	R:R:S524	3.56	No	No	0	4	5
676	R:R:S524	R:R:S527	4.89	No	No	0	5	7
677	R:R:L534	R:R:Y530	9.38	Yes	Yes	0	6	7
678	R:R:S596	R:R:V531	6.46	Yes	No	0	7	7
679	R:R:I593	R:R:M532	4.37	No	No	0	7	6
680	R:R:M532	R:R:S596	6.13	No	Yes	0	6	7
681	R:R:L534	R:R:S533	3	Yes	No	0	6	4
682	R:R:A592	R:R:L535	4.73	No	No	0	8	8
683	R:R:I593	R:R:L535	4.28	No	No	0	7	8
684	R:R:L535	R:R:S596	3	No	Yes	0	8	7
685	R:R:S589	R:R:V539	3.23	No	No	0	9	7
686	R:R:C546	R:R:F542	8.38	No	Yes	0	7	9
687	R:R:D581	R:R:F542	7.17	No	Yes	0	9	9
688	R:R:F542	R:R:F582	7.5	Yes	No	0	9	8
689	R:R:F542	R:R:M585	6.22	Yes	No	0	9	7
690	R:R:C546	R:R:I578	6.55	No	No	0	7	9
691	R:R:G547	R:R:I550	3.53	No	No	0	2	5
692	R:R:M574	R:R:Y549	10.78	No	Yes	0	9	9
693	R:R:L577	R:R:Y549	7.03	No	Yes	0	9	9
694	R:R:I578	R:R:Y549	7.25	No	Yes	0	9	9
695	R:R:H551	R:R:T555	6.85	No	No	0	4	6
696	R:R:A571	R:R:Y553	4	No	No	0	8	8
697	R:R:D567	R:R:R557	5.96	No	No	0	8	5
698	R:R:N558	R:R:P559	3.26	No	No	0	7	7
699	R:R:N558	R:R:N560	5.45	No	No	0	7	5
700	R:R:I561	R:R:N558	15.58	No	No	0	3	7
701	R:R:I561	R:R:V562	4.61	No	No	0	3	5
702	R:R:S566	R:R:V562	3.23	No	No	0	5	5
703	R:R:D567	R:R:V562	5.84	No	No	0	8	5
704	R:R:S563	R:R:S565	4.89	No	No	0	5	4
705	R:R:S563	R:R:S566	3.26	No	No	0	5	5
706	R:R:L577	R:R:L625	5.54	No	No	0	9	8
707	R:R:L577	R:R:Y626	9.38	No	Yes	0	9	9
708	R:R:F579	R:R:L583	3.65	No	No	0	7	6
709	R:R:L625	R:R:T580	4.42	No	No	0	8	8
710	R:R:D581	R:R:N618	4.04	No	No	0	9	9
711	R:R:A586	R:R:F582	8.32	No	No	0	7	8
712	R:R:F614	R:R:L583	3.65	Yes	No	27	7	6
713	R:R:I617	R:R:L583	4.28	No	No	27	7	6
714	R:R:C584	R:R:I617	3.27	No	No	0	9	7
715	R:R:C584	R:R:N618	12.6	No	No	0	9	9
716	R:R:M585	R:R:S589	3.07	No	No	0	7	9
717	R:R:F614	R:R:P587	13	Yes	No	0	7	9
718	R:R:H615	R:R:I588	3.98	Yes	No	0	6	9
719	R:R:I588	W:W:?1	7.87	No	Yes	0	9	0
720	R:R:I593	R:R:S589	4.64	No	No	0	7	9
721	R:R:F591	R:R:I602	7.54	No	No	0	8	8
722	R:R:F591	R:R:L610	4.87	No	No	0	8	8
723	R:R:A592	W:W:?1	7.6	No	Yes	0	8	0
724	R:R:L601	R:R:S594	6.01	Yes	No	0	6	8
725	R:R:A595	W:W:?1	8.69	No	Yes	0	9	0
726	R:R:S596	W:W:?1	3.11	Yes	Yes	0	7	0
727	R:R:I602	R:R:K606	5.82	No	No	0	8	6
728	R:R:S605	R:R:T603	3.2	No	No	0	7	7
729	R:R:K606	R:R:T603	3	No	No	0	6	7
730	R:R:K608	R:R:V604	3.04	No	No	0	9	8
731	R:R:A607	W:W:?1	3.26	No	Yes	0	7	0
732	R:R:F614	R:R:L610	3.65	Yes	No	0	7	8
733	R:R:H615	R:R:L611	9	Yes	Yes	0	6	7
734	R:R:L611	W:W:?1	4.77	Yes	Yes	3	7	0
735	R:R:F614	R:R:I617	5.02	Yes	No	27	7	7
736	R:R:H615	R:R:P616	3.05	Yes	No	0	6	9
737	R:R:N618	R:R:N622	8.17	No	Yes	0	9	9
738	R:R:A621	R:R:L625	3.15	No	No	0	7	8
739	R:R:N622	R:R:Y626	3.49	Yes	Yes	6	9	9
740	R:R:F624	R:R:I628	5.02	No	Yes	0	8	7
741	R:R:F629	R:R:I628	6.28	No	Yes	0	6	7
742	R:R:F633	R:R:I628	7.54	Yes	Yes	0	8	7
743	R:R:F629	R:R:R634	3.21	No	No	0	6	7
744	R:R:K631	R:R:N632	5.6	No	No	0	7	6
745	R:R:I639	R:R:R635	5.01	No	No	0	4	5
746	R:R:D636	R:R:L640	5.43	Yes	No	10	8	7
747	R:R:F637	R:R:F638	5.36	No	No	0	4	3
748	M:M:N24	M:M:T9	2.92	No	No	0	0	0
749	R:R:I570	R:R:M574	2.92	No	No	0	7	9
750	L:L:G30	M:M:Y33	2.9	No	Yes	0	0	0
751	L:L:T54	M:M:D93	2.89	No	Yes	0	0	0
752	R:R:Q194	R:R:S172	2.89	No	No	0	5	5
753	R:R:Q194	R:R:S218	2.89	No	No	0	5	3
754	R:R:E161	R:R:S164	2.87	No	No	0	6	6
755	R:R:E171	R:R:S169	2.87	No	No	0	6	4
756	R:R:I127	R:R:L125	2.85	Yes	No	0	9	8
757	R:R:I609	R:R:L613	2.85	No	No	0	8	7
758	R:R:L597	R:R:M532	2.83	No	No	0	5	6
759	R:R:E184	R:R:T159	2.82	No	No	0	4	3
760	R:R:E266	R:R:T345	2.82	No	No	0	4	3
761	R:R:K480	R:R:L477	2.82	No	No	0	7	3
762	M:M:C17	M:M:F19	2.79	No	Yes	0	0	0
763	M:M:C20	M:M:F106	2.79	No	Yes	0	0	0
764	R:R:A115	R:R:F91	2.77	No	Yes	1	8	9
765	R:R:L119	R:R:L97	2.77	No	Yes	0	8	8
766	R:R:A115	R:R:F116	2.77	No	Yes	1	8	9
767	R:R:L223	R:R:L241	2.77	Yes	No	9	8	7
768	R:R:L238	R:R:L241	2.77	No	No	0	8	7
769	R:R:L241	R:R:L244	2.77	No	No	9	7	9
770	R:R:L261	R:R:L264	2.77	No	No	0	7	6
771	R:R:A267	R:R:F278	2.77	No	Yes	0	8	8
772	L:L:L26	L:L:N78	2.75	No	No	0	0	0
773	M:M:N24	M:M:N7	2.72	No	No	0	0	0
774	R:R:N118	R:R:N93	2.72	No	No	0	6	6
775	R:R:K480	R:R:Q482	2.71	No	No	0	7	5
776	R:R:E73	R:R:K96	2.7	No	No	0	2	6
777	L:L:C31	M:M:Y33	2.69	No	Yes	0	0	0
778	R:R:L144	R:R:Q145	2.66	No	No	0	6	5
779	R:R:R247	R:R:S226	2.64	No	No	0	4	8
780	R:R:R227	R:R:S248	2.64	No	No	0	7	7
781	R:R:R283	R:R:V342	2.62	No	No	0	3	4
782	R:R:E87	R:R:Q62	2.55	No	No	0	6	4
783	M:M:F19	M:M:I21	2.51	Yes	No	0	0	0
784	M:M:Y33	R:R:T329	2.5	Yes	No	0	0	4
785	R:R:F371	R:R:L375	2.44	No	No	0	4	6
786	R:R:F624	R:R:L375	2.44	No	No	0	8	6
787	R:R:F496	R:R:L537	2.44	No	No	0	5	4
788	R:R:F590	R:R:L601	2.44	No	Yes	0	8	6
789	R:R:F591	R:R:L601	2.44	No	Yes	0	8	6
790	R:R:F637	R:R:L641	2.44	No	No	0	4	4
791	R:R:L394	R:R:R398	2.43	No	Yes	0	5	8
792	R:R:I508	R:R:Y530	2.42	No	Yes	0	6	7
793	R:R:D443	R:R:Y511	2.3	No	Yes	0	4	8
794	R:R:D567	R:R:Y553	2.3	No	No	0	8	8
795	R:R:H485	R:R:R484	2.26	No	No	0	5	4
796	L:L:G72	L:L:G73	2.11	No	No	0	0	0
797	M:M:G65	M:M:P64	2.03	No	No	0	0	0
798	M:M:C104	M:M:G107	1.96	No	No	0	0	0
799	R:R:C546	R:R:G547	1.96	No	No	0	7	2
800	M:M:A29	M:M:G30	1.95	No	No	0	0	0
801	L:L:C7	L:L:P8	1.88	No	No	0	0	0
802	R:R:C275	R:R:P350	1.88	No	No	0	9	8
803	L:L:A23	L:L:P24	1.87	No	No	0	0	0
804	L:L:G73	L:L:T69	1.82	No	No	0	0	0
805	M:M:C28	M:M:C3	1.82	No	No	5	0	0
806	M:M:C28	M:M:C51	1.82	No	Yes	5	0	0
807	M:M:C32	M:M:C51	1.82	No	Yes	5	0	0
808	M:M:C51	M:M:C84	1.82	Yes	No	5	0	0
809	R:R:G131	R:R:T130	1.82	Yes	Yes	0	5	8
810	R:R:A279	R:R:C276	1.81	No	No	0	3	9
811	L:L:P40	L:L:S43	1.78	No	No	0	0	0
812	R:R:P600	R:R:V599	1.77	No	No	0	6	5
813	R:R:G181	R:R:I155	1.76	No	No	0	5	5
814	R:R:G379	R:R:I382	1.76	No	No	0	7	5
815	R:R:G493	R:R:M492	1.75	No	No	0	8	2
816	L:L:A36	L:L:S55	1.71	No	No	0	0	0
817	L:L:L48	R:R:G131	1.71	No	Yes	0	0	5
818	M:M:A11	M:M:S22	1.71	No	No	0	0	0
819	R:R:G131	R:R:L109	1.71	Yes	No	0	5	5
820	R:R:G181	R:R:N205	1.7	No	No	0	5	2
821	R:R:A263	R:R:V262	1.7	No	No	0	3	3
822	R:R:A541	R:R:V457	1.7	No	No	0	9	8
823	R:R:C402	R:R:T388	1.69	No	No	0	7	4
824	R:R:D71	R:R:G70	1.68	No	No	0	4	1
825	R:R:F353	W:W:?1	1.68	No	Yes	0	8	0
826	R:R:D435	R:R:G439	1.68	No	No	0	4	9
827	R:R:K96	R:R:P95	1.67	No	No	0	6	5
828	R:R:K260	R:R:P256	1.67	No	No	0	4	7
829	L:L:L26	L:L:P24	1.64	No	No	0	0	0
830	L:L:E56	M:M:G98	1.64	Yes	No	0	0	0
831	M:M:E108	M:M:G107	1.64	No	No	0	0	0
832	R:R:C356	R:R:I273	1.64	No	Yes	0	9	8
833	L:L:N52	M:M:P77	1.63	No	No	0	0	0
834	R:R:S488	R:R:V489	1.62	No	No	0	3	5
835	R:R:A263	R:R:K242	1.61	No	No	0	3	6
836	R:R:A474	R:R:M475	1.61	No	No	0	7	5
837	L:L:V68	L:L:V70	1.6	No	No	0	0	0
838	L:L:V68	L:L:V76	1.6	No	No	0	0	0
839	M:M:S22	M:M:T9	1.6	No	No	0	0	0
840	M:M:V57	M:M:V78	1.6	No	No	0	0	0
841	R:R:V396	R:R:V481	1.6	Yes	No	0	8	6
842	R:R:V539	R:R:V543	1.6	No	No	0	7	4
843	L:L:T86	M:M:V96	1.59	No	No	0	0	0
844	M:M:T95	M:M:V96	1.59	Yes	No	0	0	0
845	M:M:T50	M:M:T52	1.57	Yes	No	0	0	0
846	R:R:A115	R:R:N112	1.56	No	Yes	1	8	5
847	R:R:I291	R:R:S295	1.55	Yes	No	0	2	5
848	R:R:I382	R:R:V383	1.54	No	No	0	5	9
849	R:R:I471	R:R:V556	1.54	No	No	25	8	8
850	R:R:I552	R:R:V556	1.54	No	No	25	8	8
851	L:L:S92	M:M:K86	1.53	No	No	0	0	0
852	M:M:M109	M:M:S102	1.53	No	No	0	0	0
853	R:R:H289	R:R:P290	1.53	Yes	No	0	3	1
854	R:R:K426	R:R:S427	1.53	No	No	0	5	7
855	R:R:K643	R:R:S642	1.53	No	No	0	5	5
856	M:M:I8	M:M:T6	1.52	No	No	0	0	0
857	M:M:C17	M:M:E16	1.52	No	No	0	0	0
858	R:R:K242	R:R:V221	1.52	No	No	0	6	1
859	R:R:I374	R:R:T378	1.52	No	No	0	4	3
860	R:R:I377	R:R:T378	1.52	No	No	0	5	3
861	R:R:M512	R:R:T438	1.51	No	No	0	5	5
862	R:R:F496	R:R:G493	1.51	No	No	0	5	8
863	R:R:M576	R:R:T580	1.51	No	No	0	5	8
864	L:L:K75	L:L:T69	1.5	No	No	0	0	0
865	R:R:L526	R:R:S524	1.5	No	No	0	4	5
866	R:R:N211	R:R:S235	1.49	No	No	0	2	4
867	R:R:L540	R:R:V544	1.49	No	No	0	4	4
868	R:R:L601	R:R:V599	1.49	Yes	No	0	6	5
869	M:M:A67	M:M:H68	1.46	No	No	0	0	0
870	R:R:I22	R:R:K36	1.45	Yes	No	0	4	5
871	R:R:I639	R:R:K643	1.45	No	No	0	4	5
872	M:M:P45	M:M:R44	1.44	No	Yes	0	0	0
873	M:M:P45	R:R:F333	1.44	No	No	0	0	3
874	R:R:E34	R:R:V37	1.43	No	Yes	0	2	6
875	R:R:I505	R:R:L502	1.43	No	No	0	7	3
876	R:R:I550	R:R:L554	1.43	No	No	0	5	4
877	R:R:Q183	R:R:T159	1.42	No	No	0	1	3
878	R:R:I364	R:R:N363	1.42	No	No	0	4	4
879	L:L:E9	L:L:T11	1.41	No	No	0	0	0
880	M:M:E4	M:M:T6	1.41	No	No	0	0	0
881	R:R:E39	R:R:T38	1.41	No	No	0	3	1
882	R:R:E259	R:R:T257	1.41	No	No	0	4	4
883	R:R:K133	R:R:N156	1.4	No	No	0	4	4
884	R:R:H231	R:R:S232	1.39	No	No	0	4	5
885	R:R:P272	R:R:Y271	1.39	No	Yes	0	7	9
886	R:R:A499	R:R:F503	1.39	No	No	0	4	7
887	R:R:L394	R:R:L483	1.38	No	No	0	5	3
888	R:R:H485	R:R:V481	1.38	No	No	0	5	6
889	R:R:I285	R:R:Q284	1.37	No	No	0	1	3
890	R:R:N205	R:R:Q183	1.32	No	No	0	2	1
891	L:L:D6	L:L:Q5	1.31	No	No	0	0	0
892	R:R:R59	R:R:V60	1.31	No	Yes	0	2	4
893	R:R:R59	R:R:V82	1.31	No	No	0	2	5
894	R:R:F633	R:R:T630	1.3	Yes	No	0	8	9
895	R:R:R569	R:R:T568	1.29	No	No	0	6	6
896	M:M:S2	M:M:Y31	1.27	No	No	0	0	0
897	L:L:K75	L:L:R67	1.24	No	No	0	0	0
898	R:R:H485	R:R:Q482	1.24	No	No	0	5	5
899	R:R:F278	R:R:L258	1.22	Yes	No	0	8	6
900	R:R:N204	R:R:R229	1.21	No	No	0	1	4
901	R:R:N632	R:R:R398	1.21	No	Yes	0	6	8
902	R:R:I570	R:R:Y553	1.21	No	No	0	7	8
903	R:R:N632	R:R:R635	1.21	No	No	0	6	5
904	R:R:F633	R:R:F637	1.07	Yes	No	0	8	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Q27	7.6875	4	7	0
2	L:L:C28	4.9825	4	16	0
3	L:L:M29	7.69	4	7	0
4	L:L:R35	10.725	4	8	0
5	L:L:Y37	11.5467	6	8	0
6	L:L:E56	7.8775	4	8	0
7	L:L:H79	6.13	4	16	0
8	L:L:C87	6.53	4	2	0
9	L:L:H90	5.60333	6	2	0
10	L:L:K91	4.675	4	2	0
11	M:M:F19	3.952	5	12	0
12	M:M:T25	3.864	5	11	0
13	M:M:W27	7.9525	4	0	0
14	M:M:Y33	4.462	5	7	0
15	M:M:R35	6.434	5	7	0
16	M:M:R44	7.425	4	0	0
17	M:M:Q48	6.6625	4	2	0
18	M:M:T50	3.9925	4	0	0
19	M:M:C51	3.185	4	5	0
20	M:M:Y76	5.148	5	11	0
21	M:M:D93	5.5625	4	2	0
22	M:M:T95	5.4625	4	2	0
23	M:M:F106	6.62	4	17	0
24	R:R:H20	11.0625	4	1	7
25	R:R:I22	5.3225	4	1	4
26	R:R:F30	6.59167	6	1	5
27	R:R:V37	3.9525	4	1	6
28	R:R:I40	4.472	5	1	5
29	R:R:P41	4.90833	6	1	9
30	R:R:L44	7.9475	4	1	2
31	R:R:L51	5.9075	4	1	8
32	R:R:V60	3.67	4	19	4
33	R:R:I61	5.864	5	1	8
34	R:R:F66	5.58667	6	1	8
35	R:R:L72	6.115	4	0	7
36	R:R:I75	5.915	4	1	7
37	R:R:Q79	6.666	5	2	7
38	R:R:I86	6.184	5	1	8
39	R:R:V90	5.91	4	1	9
40	R:R:F91	6.788	5	1	9
41	R:R:L97	5.655	4	1	8
42	R:R:E99	7.02	4	2	6
43	R:R:I100	4.5325	4	1	8
44	R:R:R101	10.07	4	2	5
45	R:R:E103	9.2725	4	2	5
46	R:R:K104	8.94429	7	2	6
47	R:R:L108	5.4225	4	1	9
48	R:R:N112	3.15	4	1	5
49	R:R:F116	6.2	4	1	9
50	R:R:L122	4.01	4	1	9
51	R:R:Y124	10.706	5	2	6
52	R:R:L126	10.86	4	2	7
53	R:R:I127	4.99	6	1	9
54	R:R:T130	4.638	5	1	8
55	R:R:G131	2.1575	4	0	5
56	R:R:I132	5.008	5	1	7
57	R:R:I141	4.2075	4	1	8
58	R:R:V147	4.255	4	1	6
59	R:R:L149	5.6675	4	1	8
60	R:R:D150	9.95	4	2	7
61	R:R:I151	4.13	5	1	7
62	R:R:Q152	7.86833	6	2	7
63	R:R:I160	4.986	5	1	6
64	R:R:F165	5.455	6	1	7
65	R:R:L168	6.27	4	1	5
66	R:R:I174	6.66	4	2	5
67	R:R:L175	5.07	5	1	7
68	R:R:W176	7.436	5	2	6
69	R:R:L177	4.71	4	1	9
70	R:R:N178	11.005	4	2	5
71	R:R:K179	7.586	5	2	6
72	R:R:F190	5.5	5	0	9
73	R:R:N191	4.3225	4	0	5
74	R:R:L198	6.6725	4	9	7
75	R:R:S201	8.14	4	2	7
76	R:R:L206	4.64	4	13	8
77	R:R:L209	4.8525	4	13	7
78	R:R:V213	4.805	4	0	8
79	R:R:F214	6.704	5	0	9
80	R:R:P220	5.545	4	9	8
81	R:R:L223	3.5875	4	9	8
82	R:R:I230	4.7425	4	13	8
83	R:R:Y271	7.932	5	0	9
84	R:R:I273	3.02	4	0	8
85	R:R:F278	4.4625	4	0	8
86	R:R:H289	3.8725	4	0	3
87	R:R:I291	5.9775	4	0	2
88	R:R:Y335	6.756	5	7	4
89	R:R:I359	6.0925	4	4	8
90	R:R:R366	8.455	4	0	9
91	R:R:I369	4.81	5	3	8
92	R:R:V396	3.496	5	23	8
93	R:R:R398	3.51833	6	10	8
94	R:R:L404	6.98	4	6	8
95	R:R:D408	7.778	5	6	9
96	R:R:I411	4.4225	4	0	7
97	R:R:Y414	7.314	5	3	7
98	R:R:L415	3.8775	4	0	8
99	R:R:Y429	6.466	5	4	9
100	R:R:N431	8.1525	4	4	5
101	R:R:W436	4.4225	4	4	9
102	R:R:F447	7.815	4	24	8
103	R:R:L455	5.395	4	0	7
104	R:R:E466	5.3575	4	23	9
105	R:R:R467	5.78	4	0	9
106	R:R:W468	7.03	4	0	5
107	R:R:W494	6.35	4	14	6
108	R:R:Y511	8.756	5	3	8
109	R:R:I516	3.942	5	3	8
110	R:R:L518	6.395	6	3	8
111	R:R:P519	5.2025	4	3	9
112	R:R:D521	5.045	4	26	8
113	R:R:Y530	7.3525	4	0	7
114	R:R:L534	5.2075	4	0	6
115	R:R:F542	7.3175	4	0	9
116	R:R:Y549	8.288	5	0	9
117	R:R:S596	4.668	5	0	7
118	R:R:L601	3.095	4	0	6
119	R:R:L611	6.0525	4	3	7
120	R:R:F614	6.33	4	27	7
121	R:R:H615	6.1	4	0	6
122	R:R:N622	7.244	5	6	9
123	R:R:Y626	6.74	4	6	9
124	R:R:I628	5.4775	4	0	7
125	R:R:F633	4.3625	4	0	8
126	R:R:D636	6.2075	4	10	8
127	W:W:?1	7.15273	11	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y88	L:L:Y89	12.8797	5.96	No	No	0	0	0
2	L:L:T54	M:M:D93	15.386	2.89	No	Yes	0	0	0
3	L:L:T54	L:L:Y37	14.5952	14.98	No	Yes	0	0	0
4	L:L:Y88	R:R:Y124	12.6779	25.81	No	Yes	0	0	6
5	R:R:E103	R:R:R101	11.7905	5.82	Yes	Yes	2	5	5
6	L:L:P38	L:L:Y37	12.6088	4.17	No	Yes	0	0	0
7	L:L:P38	M:M:W27	12.4094	13.51	No	Yes	0	0	0
8	M:M:I8	M:M:W27	10.5942	7.05	No	Yes	0	0	0
9	R:R:E99	R:R:Y124	37.6511	6.73	Yes	Yes	2	6	6
10	R:R:E99	R:R:K74	47.7828	9.45	Yes	No	2	6	3
11	R:R:E50	R:R:K74	50.3229	18.9	No	No	0	4	3
12	R:R:E103	R:R:K104	10.626	18.9	Yes	Yes	2	5	6
13	L:L:T46	R:R:K104	27.9213	4.5	No	Yes	2	0	6
14	L:L:T46	R:R:D81	29.1403	4.34	No	No	0	0	7
15	R:R:E50	R:R:V29	51.8465	8.56	No	No	0	4	5
16	R:R:I49	R:R:V29	51.9893	3.07	No	No	0	3	5
17	R:R:I49	R:R:R28	52.5608	11.27	No	No	0	3	1
18	R:R:N47	R:R:R28	52.9884	8.44	No	No	0	5	1
19	R:R:N47	R:R:P45	53.1309	4.89	No	No	0	5	2
20	R:R:F30	R:R:P45	52.3956	10.11	Yes	No	1	5	2
21	R:R:F30	R:R:L51	52.9588	3.65	Yes	Yes	1	5	8
22	R:R:F53	R:R:L51	53.423	8.53	No	Yes	0	6	8
23	R:R:F53	R:R:I77	53.5141	5.02	No	No	0	6	8
24	R:R:I102	R:R:I77	53.6445	4.42	No	No	0	8	8
25	R:R:I102	R:R:I127	58.292	10.3	No	Yes	0	8	9
26	R:R:K179	R:R:Q152	16.7696	4.07	Yes	Yes	2	6	7
27	R:R:D81	R:R:V82	29.2913	7.3	No	No	0	7	5
28	R:R:R59	R:R:V82	29.5931	1.31	No	No	0	2	5
29	R:R:R59	R:R:V60	29.7441	1.31	No	Yes	0	2	4
30	R:R:E87	R:R:V60	30.1982	4.28	No	Yes	0	6	4
31	R:R:E87	R:R:Q62	30.5005	2.55	No	No	0	6	4
32	R:R:A65	R:R:Q62	30.6516	3.03	No	No	0	5	4
33	R:R:A65	R:R:F66	30.0154	5.55	No	Yes	1	5	8
34	R:R:F66	R:R:F91	32.7257	4.29	Yes	Yes	1	8	9
35	R:R:F116	R:R:F91	34.228	13.93	Yes	Yes	1	9	9
36	R:R:L126	R:R:Y124	10.0261	8.21	Yes	Yes	2	7	6
37	R:R:F116	R:R:P136	35.5944	4.33	Yes	No	1	9	9
38	R:R:L148	R:R:Y124	16.2079	3.52	No	Yes	2	5	6
39	R:R:L126	R:R:S128	14.887	7.51	Yes	No	2	7	7
40	R:R:D150	R:R:L126	14.9912	9.5	Yes	Yes	2	7	7
41	R:R:I127	R:R:I151	61.9757	4.42	Yes	Yes	1	9	7
42	R:R:I151	R:R:L135	19.7171	4.28	Yes	No	0	7	7
43	R:R:I160	R:R:L135	19.7185	4.28	Yes	No	0	6	7
44	R:R:I151	R:R:L149	38.9445	4.28	Yes	Yes	1	7	8
45	R:R:F165	R:R:L149	38.8538	7.31	Yes	Yes	1	7	8
46	R:R:I151	R:R:L177	38.9445	4.28	Yes	Yes	1	7	9
47	R:R:F165	R:R:L177	38.8538	4.87	Yes	Yes	1	7	9
48	R:R:I160	R:R:I185	19.6839	5.89	Yes	No	0	6	7
49	R:R:F165	R:R:F190	79.7909	4.29	Yes	Yes	0	7	9
50	R:R:I185	R:R:L206	18.8938	5.71	No	Yes	0	7	8
51	R:R:F190	R:R:F214	80.815	3.22	Yes	Yes	0	9	9
52	R:R:I230	R:R:L206	18.7894	4.28	Yes	Yes	13	8	8
53	R:R:F214	R:R:P234	41.0124	7.22	Yes	No	0	9	9
54	R:R:F214	R:R:L238	41.0947	3.65	Yes	No	0	9	8
55	R:R:I225	R:R:I230	19.4177	4.42	No	Yes	0	8	8
56	R:R:A246	R:R:I225	19.3999	3.25	No	No	0	8	8
57	R:R:L233	R:R:P234	41.5337	4.93	No	No	0	8	9
58	R:R:L233	R:R:L238	41.3731	4.15	No	No	0	8	8
59	R:R:L233	R:R:P256	82.7488	4.93	No	No	0	8	7
60	R:R:A246	R:R:T249	19.3825	5.03	No	No	0	8	7
61	R:R:T249	R:R:T270	19.3494	6.28	No	No	0	7	8
62	R:R:T270	R:R:Y271	19.3385	8.74	No	Yes	0	8	9
63	R:R:L255	R:R:P256	81.8695	4.93	No	No	0	6	7
64	R:R:H274	R:R:L255	81.5756	6.43	No	No	0	9	6
65	R:R:H274	R:R:Y271	81.4286	5.44	No	Yes	0	9	9
66	R:R:I434	R:R:Y271	100	18.13	No	Yes	0	7	9
67	R:R:I273	R:R:I434	99.6232	2.94	Yes	No	0	8	7
68	R:R:A433	R:R:I273	97.2932	3.25	No	Yes	0	9	8
69	R:R:A433	R:R:Y429	97.1032	8.01	No	Yes	0	9	9
70	R:R:I359	R:R:Y429	95.2444	8.46	Yes	Yes	4	8	9
71	R:R:D422	R:R:I359	93.7159	9.8	No	Yes	0	9	8
72	R:R:D422	R:R:M360	92.0897	9.7	No	No	0	9	7
73	R:R:I369	R:R:M360	86.5931	5.83	Yes	No	3	8	7
74	R:R:I369	R:R:I418	38.1194	2.94	Yes	No	3	8	8
75	R:R:I418	R:R:I516	25.5093	2.94	No	Yes	3	8	8
76	R:R:I369	R:R:L415	48.3101	5.71	Yes	Yes	0	8	8
77	R:R:L415	R:R:P616	35.5189	3.28	Yes	No	0	8	9
78	R:R:H615	R:R:P616	34.9458	3.05	Yes	No	0	6	9
79	R:R:H615	R:R:S453	34.5146	8.37	Yes	No	0	6	8
80	R:R:I411	R:R:S453	34.8899	3.1	Yes	No	0	7	8
81	R:R:I411	R:R:S619	34.2403	6.19	Yes	No	0	7	9
82	R:R:D408	R:R:S619	33.8087	8.83	Yes	No	0	9	9
83	R:R:D408	R:R:N622	32.2646	8.08	Yes	Yes	6	9	9
84	R:R:N622	R:R:Y626	30.8011	3.49	Yes	Yes	6	9	9
85	R:R:R467	R:R:Y626	21.647	8.23	Yes	Yes	0	9	9
86	R:R:E466	R:R:R467	13.1206	3.49	Yes	Yes	0	9	9
87	R:R:E466	R:R:P397	10.7841	9.43	Yes	No	23	9	6
88	R:R:P397	R:R:T395	10.5851	6.99	No	No	0	6	7
89	R:R:R398	R:R:T395	10.3528	3.88	Yes	No	0	8	7
90	R:R:I516	R:R:L518	23.8806	5.71	Yes	Yes	3	8	8
91	R:R:L518	R:R:P519	11.7458	3.28	Yes	Yes	3	8	9
92	R:R:L415	R:R:Y414	12.4807	3.52	Yes	Yes	0	8	7
93	R:R:I418	R:R:Y414	12.4325	9.67	No	Yes	3	8	7
94	R:R:L611	R:R:Y414	24.0272	3.52	Yes	Yes	3	7	7
95	R:R:L611	W:W:?1	23.5888	4.77	Yes	Yes	3	7	0
96	R:R:L518	W:W:?1	11.8119	15.27	Yes	Yes	3	8	0
97	R:R:S596	W:W:?1	22.8282	3.11	Yes	Yes	0	7	0
98	R:R:A592	W:W:?1	10.0625	7.6	No	Yes	0	8	0
99	R:R:I593	R:R:L535	17.4559	4.28	No	No	0	7	8
100	R:R:M532	R:R:S596	10.0763	6.13	No	Yes	0	6	7
101	R:R:I593	R:R:S589	24.1976	4.64	No	No	0	7	9
102	R:R:M585	R:R:S589	18.1889	3.07	No	No	0	7	9
103	R:R:F542	R:R:M585	16.1874	6.22	Yes	No	0	9	7
104	R:R:C546	R:R:F542	10.1624	8.38	No	Yes	0	7	9
105	R:R:Q152	R:R:S128	14.3786	5.78	Yes	No	2	7	7
106	R:R:D150	R:R:Q152	14.3754	14.36	Yes	Yes	2	7	7
107	R:R:I151	R:R:P136	35.5065	3.39	Yes	No	1	7	9
108	R:R:L126	R:R:R101	20.3608	18.22	Yes	Yes	2	7	5
109	M:M:D93	R:R:K104	13.8384	9.68	Yes	Yes	2	0	6
110	R:R:E99	R:R:R101	10.3488	6.98	Yes	Yes	2	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N15	R:R:Y335	6.98	0	No	Yes	0	4	0	1
L:L:P16	R:R:Y335	11.13	0	No	Yes	0	4	0	1
L:L:L17	R:R:Y335	4.69	0	No	Yes	0	4	0	1
L:L:F18	R:R:I291	5.02	0	No	Yes	0	2	0	1
L:L:Q27	R:R:Y335	7.89	7	Yes	Yes	0	4	0	1
L:L:S43	R:R:Q79	5.78	0	No	Yes	0	7	0	1
L:L:T46	R:R:Q79	5.67	2	No	Yes	0	7	0	1
L:L:T46	R:R:D81	4.34	2	No	No	0	7	0	1
L:L:T46	R:R:K104	4.5	2	No	Yes	0	6	0	1
L:L:M47	R:R:K104	5.76	0	No	Yes	0	6	0	1
L:L:L48	R:R:N106	4.12	0	No	No	0	6	0	1
L:L:K51	R:R:D153	6.91	0	No	No	0	6	0	1
L:L:M71	R:R:I291	7.29	0	No	Yes	0	2	0	1
L:L:F74	R:R:H289	3.39	0	No	Yes	0	3	0	1
L:L:F74	R:R:I291	10.05	0	No	Yes	0	2	0	1
L:L:Y88	R:R:Y124	25.81	0	No	Yes	0	6	0	1
L:L:K91	R:R:Q152	5.42	2	Yes	Yes	0	7	0	1
M:M:R35	R:R:Y335	3.09	7	Yes	Yes	0	4	0	1
M:M:P42	R:R:D196	3.22	0	No	No	0	4	0	1
M:M:P42	R:R:V221	7.07	0	No	No	0	1	0	1
M:M:A43	R:R:K243	4.82	0	No	No	0	5	0	1
M:M:S89	R:R:K179	6.12	0	No	Yes	0	6	0	1
M:M:D93	R:R:E103	3.9	2	Yes	Yes	0	5	0	1
M:M:D93	R:R:K104	9.68	2	Yes	Yes	0	6	0	1
M:M:T95	R:R:E103	8.47	2	Yes	Yes	0	5	0	1
M:M:T95	R:R:K104	6.01	2	Yes	Yes	0	6	0	1
M:M:L99	R:R:Q33	3.99	0	No	No	0	4	0	1
R:R:L31	R:R:Q33	5.32	0	No	No	4	4	2	1
R:R:L55	R:R:Q79	3.99	0	No	Yes	4	7	2	1
R:R:Q79	R:R:S78	4.33	2	Yes	No	7	5	1	2
R:R:K104	R:R:Q79	13.56	2	Yes	Yes	6	7	1	1
R:R:D81	R:R:V82	7.3	0	No	No	7	5	1	2
R:R:E99	R:R:R101	6.98	2	Yes	Yes	6	5	2	2
R:R:E99	R:R:Y124	6.73	2	Yes	Yes	6	6	2	1
R:R:E103	R:R:R101	5.82	2	Yes	Yes	5	5	1	2
R:R:R101	R:R:Y124	9.26	2	Yes	Yes	5	6	2	1
R:R:L126	R:R:R101	18.22	2	Yes	Yes	7	5	2	2
R:R:E103	R:R:K104	18.9	2	Yes	Yes	5	6	1	1
R:R:K104	R:R:N129	4.2	2	Yes	No	6	8	1	2
R:R:N106	R:R:N107	14.98	0	No	No	6	5	1	2
R:R:L126	R:R:Y124	8.21	2	Yes	Yes	7	6	2	1
R:R:L148	R:R:Y124	3.52	2	No	Yes	5	6	2	1
R:R:L126	R:R:S128	7.51	2	Yes	No	7	7	2	2
R:R:D150	R:R:L126	9.5	2	Yes	Yes	7	7	2	2
R:R:D150	R:R:S128	5.89	2	Yes	No	7	7	2	2
R:R:Q152	R:R:S128	5.78	2	Yes	No	7	7	1	2
R:R:G131	R:R:N156	3.39	0	Yes	No	5	4	1	2
R:R:I174	R:R:L148	8.56	2	Yes	No	5	5	2	2
R:R:L148	R:R:W176	10.25	2	No	Yes	5	6	2	2
R:R:D150	R:R:Q152	14.36	2	Yes	Yes	7	7	2	1
R:R:D150	R:R:W176	10.05	2	Yes	Yes	7	6	2	2
R:R:Q152	R:R:W176	4.38	2	Yes	Yes	7	6	1	2
R:R:N178	R:R:Q152	13.2	2	Yes	Yes	5	7	2	1
R:R:K179	R:R:Q152	4.07	2	Yes	Yes	6	7	1	1
R:R:D153	R:R:K179	6.91	0	No	Yes	6	6	1	1
R:R:D196	R:R:S172	8.83	0	No	No	4	5	1	2
R:R:I174	R:R:W176	7.05	2	Yes	Yes	5	6	2	2
R:R:D196	R:R:I174	4.2	0	No	Yes	4	5	1	2
R:R:K179	R:R:N178	8.39	2	Yes	Yes	6	5	1	2
R:R:D202	R:R:K179	12.44	0	No	Yes	5	6	2	1
R:R:I222	R:R:V221	6.14	0	No	No	3	1	2	1
R:R:I222	R:R:K243	7.27	0	No	No	3	5	2	1
R:R:E266	R:R:K243	8.1	0	No	No	4	5	2	1
R:R:E287	R:R:H289	6.15	0	No	Yes	2	3	2	1
R:R:C338	R:R:H289	4.42	21	No	Yes	8	3	2	1
R:R:T329	R:R:Y330	3.75	0	No	No	4	4	1	2
R:R:E332	R:R:F333	4.66	0	No	No	5	3	2	1
M:M:Y33	R:R:T329	2.5	7	Yes	No	0	4	0	1
R:R:G131	R:R:T130	1.82	0	Yes	Yes	5	8	1	2
L:L:L48	R:R:G131	1.71	0	No	Yes	0	5	0	1
R:R:G131	R:R:L109	1.71	0	Yes	No	5	5	1	2
R:R:I291	R:R:S295	1.55	0	Yes	No	2	5	1	2
R:R:H289	R:R:P290	1.53	0	Yes	No	3	1	1	2
R:R:K242	R:R:V221	1.52	0	No	No	6	1	2	1
M:M:P45	R:R:F333	1.44	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I411	R:R:S453	3.1	0	Yes	No	7	8	2	1
R:R:T449	R:R:Y414	16.23	0	No	Yes	8	7	2	2
R:R:I516	R:R:Y414	3.63	3	Yes	Yes	8	7	2	2
R:R:L611	R:R:Y414	3.52	3	Yes	Yes	7	7	1	2
R:R:L518	R:R:T449	2.95	3	Yes	No	8	8	1	2
R:R:V450	R:R:Y511	6.31	3	No	Yes	8	8	2	2
R:R:P519	R:R:V450	3.53	3	Yes	No	9	8	1	2
R:R:H615	R:R:S453	8.37	0	Yes	No	6	8	2	1
R:R:S453	W:W:?1	5.18	0	No	Yes	8	0	1	0
R:R:P519	R:R:Y511	8.34	3	Yes	Yes	9	8	1	2
R:R:I516	R:R:V514	3.07	3	Yes	No	8	8	2	2
R:R:M520	R:R:V514	9.13	3	No	No	8	8	1	2
R:R:I516	R:R:L518	5.71	3	Yes	Yes	8	8	2	1
R:R:L518	R:R:P519	3.28	3	Yes	Yes	8	9	1	1
R:R:L518	R:R:M520	4.24	3	Yes	No	8	8	1	1
R:R:L518	R:R:L611	6.92	3	Yes	Yes	8	7	1	1
R:R:L518	W:W:?1	15.27	3	Yes	Yes	8	0	1	0
R:R:P519	W:W:?1	5.66	3	Yes	Yes	9	0	1	0
R:R:M520	W:W:?1	15.59	3	No	Yes	8	0	1	0
R:R:I522	R:R:S596	4.64	0	No	Yes	6	7	2	1
R:R:S596	R:R:V531	6.46	0	Yes	No	7	7	1	2
R:R:M532	R:R:S596	6.13	0	No	Yes	6	7	2	1
R:R:A592	R:R:L535	4.73	0	No	No	8	8	1	2
R:R:L535	R:R:S596	3	0	No	Yes	8	7	2	1
R:R:H615	R:R:I588	3.98	0	Yes	No	6	9	2	1
R:R:I588	W:W:?1	7.87	0	No	Yes	9	0	1	0
R:R:A592	W:W:?1	7.6	0	No	Yes	8	0	1	0
R:R:A595	W:W:?1	8.69	0	No	Yes	9	0	1	0
R:R:S596	W:W:?1	3.11	0	Yes	Yes	7	0	1	0
R:R:A607	W:W:?1	3.26	0	No	Yes	7	0	1	0
R:R:H615	R:R:L611	9	0	Yes	Yes	6	7	2	1
R:R:L611	W:W:?1	4.77	3	Yes	Yes	7	0	1	0
R:R:F353	W:W:?1	1.68	0	No	Yes	8	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8I2G_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	762
Number of Links	904
Number of Hubs	127
Number of Links mediated by Hubs	447
Number of Communities	27
Number of Nodes involved in Communities	197
Number of Links involved in Communities	271

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	1838865
Length Of Smallest Path	3
Average Path Length	40.9008
Length of Longest Path	74
Minimum Path Strength	1.185
Average Path Strength	6.41142
Maximum Path Strength	20.665
Minimum Path Correlation	0.7
Average Path Correlation	0.986748
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.22222
Average % Of Corr. Nodes	44.9039
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.5808
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • G protein activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • developmental process • multicellular organism development • skeletal system development • anatomical structure development • animal organ development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to endogenous stimulus • response to alcohol • response to prostaglandin E • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • apical part of cell • plasma membrane region • apical plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • follicle-stimulating hormone receptor activity • protein-hormone receptor activity • gonad development • reproductive system development • reproductive process • sex differentiation • developmental process involved in reproduction • male gonad development • male sex differentiation • development of primary male sexual characteristics • development of primary sexual characteristics • reproductive structure development • spermatogenesis • sexual reproduction • multicellular organismal reproductive process • male gamete generation • gamete generation • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • hormone-mediated signaling pathway • ovulation cycle process • development of primary female sexual characteristics • ovulation cycle • ovarian follicle development • rhythmic process • female gonad development • female sex differentiation • follicle-stimulating hormone signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of protein kinase A signaling • protein kinase A signaling • female gamete generation • cellular response to gonadotropin stimulus • response to gonadotropin • cellular response to follicle-stimulating hormone stimulus • response to follicle-stimulating hormone • receptor complex • molecular function activator activity • signaling receptor binding • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • follicle-stimulating hormone activity • receptor ligand activity • positive regulation of cell population proliferation • regulation of cell population proliferation • gonadotropin secretion • transport • hormone secretion • localization • secretion by cell • signal release • regulation of biological quality • secretion • regulation of hormone levels • follicle-stimulating hormone secretion • export from cell • establishment of localization • endocrine hormone secretion • endocrine process • hormone transport • phenol-containing compound metabolic process • modified amino acid metabolic process • metabolic process • hormone metabolic process • thyroid hormone generation • thyroid hormone metabolic process • developmental growth • growth • organ growth • thyroid gland development • endocrine system development • gland development • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • regulation of signaling receptor activity • regulation of molecular function • regulation of steroid biosynthetic process • steroid metabolic process • regulation of lipid metabolic process • lipid biosynthetic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • steroid biosynthetic process • regulation of biosynthetic process • regulation of steroid metabolic process • primary metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • positive regulation of lipid biosynthetic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • regulation of growth • regulation of developmental growth • regulation of developmental process • negative regulation of developmental process • negative regulation of biological process • negative regulation of organ growth • negative regulation of developmental growth • negative regulation of growth • regulation of organ growth • regulation of multicellular organismal process • negative regulation of multicellular organismal process • luteinizing hormone secretion • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • Golgi apparatus • membrane-enclosed lumen • endomembrane system • intracellular organelle lumen • Golgi lumen • organelle lumen • pituitary gonadotropin complex • follicle-stimulating hormone complex • multi-multicellular organism process • female pregnancy • multi-organism reproductive process • positive regulation of gene expression • Sertoli cell proliferation • epithelial cell proliferation • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • cell differentiation • osteoclast differentiation • regulation of immune system process • regulation of multicellular organismal development • hemopoiesis • regulation of myeloid cell differentiation • regulation of myeloid leukocyte differentiation • myeloid cell differentiation • immune system process • regulation of hemopoiesis • leukocyte differentiation • homeostatic process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • positive regulation of multicellular organismal process • positive regulation of bone resorption • cellular response to growth factor stimulus • cell surface receptor protein serine/threonine kinase signaling pathway • cell surface receptor signaling pathway • cellular response to transforming growth factor beta stimulus • response to transforming growth factor beta • transforming growth factor beta receptor signaling pathway • response to growth factor • transforming growth factor beta receptor superfamily signaling pathway • enzyme-linked receptor protein signaling pathway • ketone metabolic process • C21-steroid hormone metabolic process • progesterone metabolic process • small molecule metabolic process • hormone biosynthetic process • steroid hormone biosynthetic process • olefinic compound biosynthetic process • small molecule biosynthetic process • progesterone biosynthetic process • C21-steroid hormone biosynthetic process • olefinic compound metabolic process • ketone biosynthetic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • L domain-like • Cystine-knot cytokines • Cystine-knot cytokines
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • L domain-like • Cystine-knot cytokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	O6F
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	O6F
Name	N-tert-butyl-N-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamide
Synonyms
Identifier
Formula	C26 H33 N3 O3 S
Molecular Weight	467.624
SMILES
PubChem	67530240
Formal Charge	0
Total Atoms	66
Total Chiral Atoms	0
Total Bonds	69
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P23945
Sequence	>8I2G_nogp_Chain_R C H H R I C H C S N R V F L C Q E S K V T E I P S D L P R N A I E L R F V L T K L R V I Q K G A F S G F G D L E K I E I S Q N D V L E V I E A D V F S N L P K L H E I R I E K A N N L L Y I N P E A F Q N L P N L Q Y L L I S N T G I K H L P D V H K I H S L Q K V L L D I Q D N I N I H T I E R N S F V G L S F E S V I L W L N K N G I Q E I H N C A F N G T Q L D E L N L S D N N N L E E L P N D V F H G A S G P V I L D I S R T R I H S L P S Y G L E N L K K L R A R S T Y N L K K L P T L E K L V A L M E A S L T Y P I H C C A F A N W R R Q I S E L H P I C N K S T Y T E F D Y D L C N E V V D V T C S P K P D A F N P C E D I M G Y N I L R V L I W F I S I L A I T G N I I V L V I L T T S Q Y K L T V P R F L M C N L A F A D L C I G I Y L L L I A S V D I H T K S Q Y H N Y A I D W Q T G A G C D A A G F F T V F A S E L S V Y T L T A I T L E R W H T I T H A M Q L D C K V Q L R H A A S V M V M G W I F A F A A A L F P I F G I S S Y M K V S I C L P M D I D S P L S Q L Y V M S L L V L N V L A F V V I C G C Y I H I Y L T V R N P N I V S S S S D T R I A K R M A M L I F T D F L C M A P I S F F A I S A S L K V P L I T V S K A K I L L V L F H P I N S C A N P F L Y A I F T K N F R R D F F I L L S K C G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I2H	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	-	-	-	6	2023-03-22	10.1038/s41467-023-36170-3
	8I2G	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	Glycoprotein hormones α chain	Compound 716340	Gs/β1/γ2	2.8	2023-03-29	10.1038/s41467-023-36170-3
	8I2G (No Gprot)	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	Glycoprotein hormones α chain	Compound 716340		2.8	2023-03-29	10.1038/s41467-023-36170-3

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