psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G38	R:R:P39	4.06	No	Yes	0	4	8
2	R:R:F40	R:R:P39	4.33	Yes	Yes	3	5	8
3	R:R:P196	R:R:P39	9.74	Yes	Yes	3	3	8
4	R:R:K200	R:R:P39	11.71	No	Yes	0	4	8
5	R:R:F40	R:R:G122	3.01	Yes	No	0	5	8
6	R:R:F40	R:R:H123	6.79	Yes	Yes	3	5	2
7	R:R:F40	R:R:W195	4.01	Yes	Yes	3	5	3
8	R:R:F40	R:R:P196	5.78	Yes	Yes	3	5	3
9	R:R:G42	R:R:P43	4.06	No	No	7	4	4
10	R:R:G42	R:R:Y118	2.9	No	No	7	4	5
11	R:R:P43	R:R:Y118	18.08	No	No	7	4	5
12	R:R:R50	R:R:Y45	8.23	No	No	0	2	2
13	R:R:Y45	R:R:Y53	4.96	No	No	0	2	4
14	R:R:I47	R:R:P301	3.39	No	No	0	3	3
15	R:R:A48	R:R:Y53	4	No	No	0	4	4
16	R:R:P49	R:R:W51	14.86	No	No	8	4	2
17	R:R:P49	R:R:V52	3.53	No	No	8	4	4
18	R:R:H54	R:R:R50	19.18	No	No	0	4	2
19	R:R:V52	R:R:W51	2.45	No	No	8	4	2
20	R:R:L199	R:R:Y53	8.21	No	No	0	5	4
21	R:R:Q114	R:R:T56	4.25	Yes	No	0	5	4
22	R:R:L199	R:R:T56	4.42	No	No	0	5	4
23	R:R:T56	R:R:Y309	3.75	No	No	0	4	5
24	R:R:Q114	R:R:S57	2.89	Yes	No	0	5	5
25	R:R:F62	R:R:V58	2.62	No	No	0	4	5
26	R:R:M60	R:R:W59	3.49	No	Yes	0	6	4
27	R:R:V63	R:R:W59	8.58	No	Yes	0	7	4
28	R:R:W59	R:R:Y309	9.65	Yes	No	0	4	5
29	R:R:S313	R:R:W59	2.47	No	Yes	0	5	4
30	R:R:M60	R:R:Q114	5.44	No	Yes	0	6	5
31	R:R:I316	R:R:V63	6.14	No	No	0	6	7
32	R:R:S107	R:R:V64	8.08	No	No	0	6	5
33	R:R:S67	R:R:T103	9.59	No	No	1	8	6
34	R:R:S67	R:R:T315	3.2	No	Yes	1	8	9
35	R:R:L100	R:R:V68	2.98	No	No	0	7	5
36	R:R:F69	R:R:L73	2.44	No	No	0	3	7
37	R:R:N71	R:R:T70	4.39	Yes	No	1	9	8
38	R:R:P319	R:R:T70	3.5	No	No	1	9	8
39	R:R:A96	R:R:N71	3.13	No	Yes	0	9	9
40	R:R:D99	R:R:N71	5.39	Yes	Yes	1	9	9
41	R:R:L100	R:R:N71	6.87	No	Yes	0	7	9
42	R:R:N71	R:R:P319	6.52	Yes	No	1	9	9
43	R:R:F324	R:R:L73	2.44	Yes	No	1	6	7
44	R:R:I333	R:R:L73	7.14	No	No	1	6	7
45	R:R:A96	R:R:V74	3.39	No	No	0	9	9
46	R:R:V323	R:R:V74	9.62	No	No	0	7	9
47	R:R:R85	R:R:T78	2.59	No	No	0	7	7
48	R:R:T78	R:R:V93	4.76	No	No	0	7	7
49	R:R:F81	R:R:K80	9.93	No	No	0	5	6
50	R:R:C332	R:R:F81	13.97	No	No	0	6	5
51	R:R:F81	R:R:Q335	4.68	No	No	0	5	4
52	R:R:K82	R:R:R85	6.19	No	No	0	5	7
53	R:R:F329	R:R:L84	17.05	Yes	No	0	8	8
54	R:R:C332	R:R:L84	6.35	No	No	0	6	8
55	R:R:H86	R:R:P87	16.78	No	No	0	8	6
56	R:R:F164	R:R:P87	2.89	Yes	No	0	7	6
57	R:R:E150	R:R:L88	3.98	No	No	1	8	8
58	R:R:L88	R:R:V154	7.45	No	No	0	8	8
59	R:R:F164	R:R:L88	4.87	Yes	No	1	7	8
60	R:R:L92	R:R:N89	5.49	No	No	5	8	9
61	R:R:F329	R:R:N89	9.67	Yes	No	5	8	9
62	R:R:A166	R:R:W90	2.59	No	No	0	1	5
63	R:R:A169	R:R:W90	2.59	No	No	0	7	5
64	R:R:I91	R:R:N94	2.83	Yes	Yes	1	8	9
65	R:R:I91	R:R:S143	6.19	Yes	Yes	1	8	8
66	R:R:I146	R:R:I91	4.42	No	Yes	0	6	8
67	R:R:I147	R:R:I91	7.36	No	Yes	1	9	8
68	R:R:E150	R:R:I91	6.83	No	Yes	1	8	8
69	R:R:L92	R:R:V323	5.96	No	No	5	8	7
70	R:R:F329	R:R:L92	2.44	Yes	No	5	8	8
71	R:R:N94	R:R:S143	4.47	Yes	Yes	1	9	8
72	R:R:I173	R:R:N94	5.66	No	Yes	0	7	9
73	R:R:N94	R:R:W177	9.04	Yes	Yes	0	9	9
74	R:R:D99	R:R:L95	2.71	Yes	Yes	1	9	9
75	R:R:L95	R:R:S143	3	Yes	Yes	1	9	8
76	R:R:L144	R:R:L95	2.77	No	Yes	1	8	9
77	R:R:L95	R:R:N318	2.75	Yes	No	1	9	9
78	R:R:D99	R:R:T315	8.67	Yes	Yes	1	9	9
79	R:R:D99	R:R:N318	5.39	Yes	No	1	9	9
80	R:R:A101	R:R:C136	3.61	No	No	0	5	7
81	R:R:E102	R:R:G137	3.27	No	No	0	7	7
82	R:R:E102	R:R:T315	2.82	No	Yes	0	7	9
83	R:R:T103	R:R:T315	4.71	No	Yes	1	6	9
84	R:R:I105	R:R:T132	4.56	No	No	0	5	4
85	R:R:S107	R:R:T108	4.8	No	No	0	6	7
86	R:R:I109	R:R:T108	4.56	No	No	0	5	7
87	R:R:I109	R:R:L121	5.71	No	Yes	0	5	6
88	R:R:I109	R:R:Q129	8.23	No	No	0	5	6
89	R:R:N113	R:R:S116	2.98	Yes	No	0	6	3
90	R:R:F119	R:R:N113	12.08	Yes	Yes	3	8	6
91	R:R:L121	R:R:N113	2.75	Yes	Yes	3	6	6
92	R:R:N113	R:R:T201	2.92	Yes	Yes	0	6	6
93	R:R:Q114	R:R:T201	8.5	Yes	Yes	0	5	6
94	R:R:S116	R:R:V120	8.08	No	No	0	3	3
95	R:R:V120	R:R:Y118	8.83	No	No	0	3	5
96	R:R:F119	R:R:L121	3.65	Yes	Yes	3	8	6
97	R:R:F119	R:R:G122	3.01	Yes	No	0	8	8
98	R:R:C126	R:R:F119	2.79	No	Yes	3	9	8
99	R:R:C203	R:R:F119	4.19	Yes	Yes	3	9	8
100	R:R:L121	R:R:M125	7.07	Yes	No	0	6	6
101	R:R:H123	R:R:V127	4.15	Yes	No	0	2	6
102	R:R:H123	R:R:W195	3.17	Yes	Yes	3	2	3
103	R:R:C126	R:R:P196	3.77	No	Yes	3	9	3
104	R:R:C126	R:R:C203	7.28	No	Yes	3	9	9
105	R:R:I188	R:R:V127	3.07	No	No	0	5	6
106	R:R:C203	R:R:Q129	3.05	Yes	No	0	9	6
107	R:R:G130	R:R:Y194	4.35	No	Yes	0	5	6
108	R:R:T184	R:R:Y131	7.49	No	No	2	6	5
109	R:R:I188	R:R:Y131	7.25	No	No	2	5	5
110	R:R:Y131	R:R:Y194	7.94	No	Yes	2	5	6
111	R:R:K312	R:R:V133	3.04	No	Yes	4	8	6
112	L:L:?1	R:R:V133	2.97	Yes	Yes	4	0	6
113	R:R:S134	R:R:T184	7.99	No	No	2	5	6
114	R:R:S134	R:R:Y194	5.09	No	Yes	2	5	6
115	R:R:L135	R:R:W177	4.56	No	Yes	0	5	9
116	R:R:A180	R:R:I138	3.25	No	No	0	8	6
117	R:R:C227	R:R:I138	8.18	Yes	No	0	5	6
118	R:R:G140	R:R:T139	3.64	No	Yes	0	9	7
119	R:R:T139	R:R:W177	12.13	Yes	Yes	0	7	9
120	R:R:G140	R:R:S143	3.71	No	Yes	0	9	8
121	R:R:L141	R:R:Y277	8.21	No	Yes	0	8	9
122	R:R:L141	R:R:W281	6.83	No	Yes	0	8	8
123	R:R:A145	R:R:W142	2.59	No	Yes	0	7	5
124	R:R:F175	R:R:W142	6.01	No	Yes	2	3	5
125	R:R:W142	R:R:W179	6.56	Yes	Yes	2	5	4
126	R:R:C227	R:R:W142	2.61	Yes	Yes	2	5	5
127	R:R:P231	R:R:W142	10.81	No	Yes	0	9	5
128	R:R:S143	R:R:S176	3.26	Yes	No	0	8	6
129	R:R:L144	R:R:N318	4.12	No	No	1	8	9
130	R:R:L144	R:R:Y322	9.38	No	Yes	1	8	9
131	R:R:A145	R:R:I234	4.87	No	No	0	7	7
132	R:R:G172	R:R:I146	3.53	No	No	0	6	6
133	R:R:I147	R:R:R151	6.26	No	No	1	9	9
134	R:R:I147	R:R:Y322	3.63	No	Yes	1	9	9
135	R:R:I235	R:R:S148	6.19	No	No	1	8	9
136	R:R:C238	R:R:S148	5.16	No	No	0	7	9
137	R:R:S148	R:R:Y239	5.09	No	Yes	1	9	9
138	R:R:W149	R:R:W152	3.75	No	Yes	0	6	7
139	R:R:M153	R:R:W149	9.31	No	No	0	4	6
140	R:R:E150	R:R:F164	12.83	No	Yes	1	8	7
141	R:R:R151	R:R:Y239	8.23	No	Yes	1	9	9
142	R:R:R151	R:R:Y322	6.17	No	Yes	1	9	9
143	R:R:C156	R:R:W152	6.53	No	Yes	0	7	7
144	R:R:P158	R:R:W152	10.81	Yes	Yes	0	7	7
145	R:R:C238	R:R:W152	5.22	No	Yes	0	7	7
146	R:R:Q241	R:R:W152	6.57	No	Yes	0	4	7
147	R:R:M153	R:R:P158	3.35	No	Yes	0	4	7
148	R:R:F164	R:R:M153	3.73	Yes	No	0	7	4
149	R:R:V155	R:R:V242	4.81	No	No	0	8	9
150	R:R:K157	R:R:R163	8.66	No	No	0	5	4
151	R:R:F159	R:R:P158	15.89	No	Yes	0	6	7
152	R:R:F159	R:R:V162	6.55	No	No	0	6	3
153	R:R:F164	R:R:L168	3.65	Yes	No	0	7	5
154	R:R:A169	R:R:F164	2.77	No	Yes	0	7	7
155	R:R:D165	R:R:K167	8.3	No	No	0	7	4
156	R:R:F175	R:R:W179	14.03	No	Yes	2	3	4
157	R:R:S176	R:R:W177	4.94	No	Yes	0	6	9
158	R:R:W179	R:R:W183	14.99	Yes	Yes	2	4	5
159	R:R:T226	R:R:W179	2.43	No	Yes	2	4	4
160	R:R:V222	R:R:W183	3.68	No	Yes	0	4	5
161	R:R:L223	R:R:W183	3.42	No	Yes	2	5	5
162	R:R:T226	R:R:W183	24.26	No	Yes	2	4	5
163	R:R:C227	R:R:W183	3.92	Yes	Yes	2	5	5
164	R:R:T184	R:R:Y194	3.75	No	Yes	2	6	6
165	R:R:A185	R:R:F189	2.77	No	No	0	4	4
166	R:R:P186	R:R:P187	5.84	Yes	No	2	3	8
167	R:R:P186	R:R:W191	5.4	Yes	Yes	2	3	5
168	R:R:P186	R:R:Y219	5.56	Yes	Yes	2	3	6
169	R:R:P187	R:R:Y194	16.69	No	Yes	2	8	6
170	R:R:P187	R:R:Y219	12.52	No	Yes	2	8	6
171	R:R:I188	R:R:Y194	2.42	No	Yes	2	5	6
172	R:R:G190	R:R:R193	3	No	No	0	5	4
173	R:R:S218	R:R:W191	11.12	No	Yes	0	5	5
174	R:R:W191	R:R:Y219	4.82	Yes	Yes	2	5	6
175	R:R:V222	R:R:W191	2.45	No	Yes	0	4	5
176	R:R:S192	R:R:V216	8.08	No	No	0	6	4
177	R:R:S192	R:R:Y219	5.09	No	Yes	0	6	6
178	R:R:P205	R:R:Y194	2.78	No	Yes	0	5	6
179	R:R:P196	R:R:W195	9.46	Yes	Yes	3	3	3
180	R:R:D206	R:R:W195	5.58	No	Yes	3	3	3
181	R:R:W195	R:R:Y213	5.79	Yes	Yes	0	3	3
182	R:R:C203	R:R:P196	5.65	Yes	Yes	3	9	3
183	R:R:G198	R:R:H197	3.18	No	Yes	0	4	3
184	R:R:H197	R:R:S202	2.79	Yes	No	0	3	5
185	R:R:G204	R:R:H197	3.18	No	Yes	0	4	3
186	R:R:F208	R:R:H197	7.92	Yes	Yes	4	5	3
187	R:R:H197	R:R:Y284	3.27	Yes	Yes	4	3	7
188	R:R:A308	R:R:H197	2.93	No	Yes	0	5	3
189	R:R:L199	R:R:T201	2.95	No	Yes	0	5	6
190	R:R:S202	R:R:T201	3.2	No	Yes	0	5	6
191	R:R:G204	R:R:P205	4.06	No	No	0	4	5
192	L:L:?1	R:R:P205	7.64	Yes	No	0	0	5
193	R:R:D206	R:R:S209	8.83	No	No	3	3	4
194	R:R:D206	R:R:S211	7.36	No	No	3	3	3
195	R:R:M220	R:R:V207	7.61	No	No	0	5	4
196	R:R:F208	R:R:Y284	8.25	Yes	Yes	4	5	7
197	R:R:F208	R:R:F299	4.29	Yes	Yes	0	5	4
198	R:R:A304	R:R:F208	5.55	No	Yes	0	4	5
199	R:R:F208	R:R:P307	4.33	Yes	Yes	4	5	6
200	R:R:S209	R:R:S211	4.89	No	No	3	4	3
201	R:R:S211	R:R:Y213	10.17	No	Yes	0	3	3
202	R:R:V216	R:R:Y213	3.79	No	Yes	0	4	3
203	R:R:P295	R:R:Q217	4.74	No	No	0	1	2
204	R:R:M220	R:R:Y219	5.99	No	Yes	0	5	6
205	R:R:L223	R:R:Y219	9.38	No	Yes	2	5	6
206	L:L:?1	R:R:M220	2.82	Yes	No	0	0	5
207	R:R:A292	R:R:I221	3.25	No	No	0	4	4
208	R:R:C227	R:R:L223	3.17	Yes	No	2	5	5
209	R:R:I229	R:R:M224	4.37	No	No	0	4	5
210	R:R:C289	R:R:M224	3.24	No	No	0	5	5
211	R:R:C227	R:R:T226	5.07	Yes	No	2	5	4
212	R:R:I230	R:R:P231	3.39	No	No	0	5	9
213	R:R:P231	R:R:Y277	2.78	No	Yes	0	9	9
214	R:R:L232	R:R:M236	5.65	No	No	0	7	4
215	R:R:L232	R:R:Y277	9.38	No	Yes	0	7	9
216	R:R:I235	R:R:Y239	2.42	No	Yes	1	8	9
217	R:R:I235	R:R:Y277	2.42	No	Yes	0	8	9
218	R:R:I274	R:R:M236	4.37	No	No	0	8	4
219	R:R:V270	R:R:Y239	5.05	No	Yes	0	8	9
220	R:R:M273	R:R:Y239	5.99	No	Yes	0	8	9
221	R:R:L244	R:R:Q241	3.99	No	No	0	1	4
222	R:R:L244	R:R:W243	3.42	No	Yes	0	1	6
223	R:R:R247	R:R:W243	5	No	Yes	6	5	6
224	R:R:E263	R:R:W243	5.45	Yes	Yes	6	8	6
225	R:R:T267	R:R:W243	9.7	No	Yes	6	8	6
226	R:R:E263	R:R:I246	2.73	Yes	No	0	8	8
227	R:R:I246	R:R:V266	4.61	No	No	0	8	8
228	R:R:K251	R:R:R247	8.66	No	No	0	4	5
229	R:R:E263	R:R:R247	5.82	Yes	No	6	8	5
230	R:R:A250	R:R:Q260	4.55	No	No	0	4	3
231	R:R:Q253	R:R:S256	4.33	No	No	0	5	5
232	R:R:S256	R:R:S258	3.26	No	No	0	5	3
233	R:R:S256	R:R:T259	6.4	No	No	0	5	4
234	R:R:E257	R:R:K261	5.4	No	No	0	4	5
235	R:R:E263	R:R:T267	4.23	Yes	No	6	8	8
236	R:R:E265	R:R:R268	8.14	No	No	0	8	6
237	R:R:M269	R:R:M273	4.33	No	No	0	8	8
238	R:R:M269	R:R:M325	7.22	No	No	0	8	7
239	R:R:I321	R:R:V272	3.07	No	No	0	8	6
240	R:R:M273	R:R:Y322	9.58	No	Yes	0	8	9
241	R:R:F275	R:R:V279	7.87	No	No	0	4	5
242	R:R:A276	R:R:I321	3.25	No	No	0	6	8
243	R:R:C280	R:R:W281	5.22	No	Yes	0	8	8
244	R:R:A314	R:R:C280	3.61	No	No	0	9	8
245	R:R:A311	R:R:W281	3.89	No	Yes	0	7	8
246	L:L:?1	R:R:W281	5.3	Yes	Yes	0	0	8
247	R:R:G282	R:R:P283	4.06	No	No	0	5	9
248	R:R:G282	R:R:T285	3.64	No	No	0	5	7
249	R:R:F310	R:R:P283	10.11	No	No	0	7	9
250	R:R:P307	R:R:Y284	4.17	Yes	Yes	4	6	7
251	L:L:?1	R:R:Y284	16.37	Yes	Yes	4	0	7
252	R:R:F286	R:R:T285	3.89	No	No	0	6	7
253	R:R:F287	R:R:F299	7.5	No	Yes	0	4	4
254	R:R:F287	R:R:M303	3.73	No	No	0	4	4
255	R:R:F287	R:R:P307	8.67	No	Yes	0	4	6
256	R:R:F290	R:R:N294	7.25	No	Yes	0	4	4
257	R:R:F290	R:R:F299	4.29	No	Yes	0	4	4
258	R:R:A291	R:R:F299	2.77	No	Yes	0	4	4
259	R:R:A293	R:R:N294	3.13	No	Yes	0	4	4
260	R:R:N294	R:R:Y297	4.65	Yes	No	0	4	3
261	R:R:H300	R:R:P301	4.58	No	No	0	4	3
262	R:R:A305	R:R:Y309	5.34	No	No	0	4	5
263	L:L:?1	R:R:K312	6.56	Yes	No	4	0	8
264	R:R:F324	R:R:P319	2.89	Yes	No	1	6	9
265	R:R:F324	R:R:V320	2.62	Yes	No	0	6	7
266	R:R:I321	R:R:Y322	6.04	No	Yes	0	8	9
267	R:R:F329	R:R:V323	5.24	Yes	No	5	8	7
268	R:R:F324	R:R:I333	5.02	Yes	No	1	6	6
269	R:R:M325	R:R:R330	3.72	No	No	0	7	9
270	R:R:N326	R:R:Q328	7.92	No	No	0	8	7
271	R:R:F329	R:R:N326	4.83	Yes	No	0	8	8
272	R:R:G210	R:R:G296	2.11	No	No	0	1	2
273	L:L:?1	R:R:C228	2.11	Yes	No	0	0	8
274	R:R:R193	R:R:Y213	2.06	No	Yes	0	4	3
275	R:R:G198	R:R:P301	2.03	No	No	0	4	3
276	R:R:G215	R:R:P214	2.03	No	No	0	4	2
277	R:R:P283	R:R:P307	1.95	No	Yes	0	9	6
278	R:R:A48	R:R:P49	1.87	No	No	0	4	4
279	R:R:A185	R:R:P186	1.87	No	Yes	0	4	3
280	R:R:G117	R:R:S116	1.86	No	No	0	4	3
281	R:R:G215	R:R:S192	1.86	No	No	0	4	6
282	R:R:G210	R:R:S209	1.86	No	No	0	1	4
283	R:R:G215	R:R:S218	1.86	No	No	0	4	5
284	R:R:A245	R:R:C156	1.81	No	No	0	5	7
285	R:R:G72	R:R:L75	1.71	No	Yes	0	4	7
286	R:R:A106	R:R:V133	1.7	No	Yes	0	6	6
287	R:R:A288	R:R:V207	1.7	No	No	0	6	4
288	R:R:C136	R:R:T139	1.69	No	Yes	0	7	7
289	R:R:A98	R:R:T139	1.68	No	Yes	0	8	7
290	R:R:A250	R:R:T259	1.68	No	No	0	4	4
291	R:R:K157	R:R:P158	1.67	No	Yes	0	5	7
292	R:R:E41	R:R:G42	1.64	No	No	0	4	4
293	R:R:L306	R:R:P307	1.64	No	Yes	0	5	6
294	R:R:S110	R:R:S202	1.63	No	No	0	6	5
295	R:R:N294	R:R:P295	1.63	Yes	No	0	4	1
296	R:R:S57	R:R:V58	1.62	No	No	0	5	5
297	R:R:A66	R:R:I316	1.62	No	No	0	5	6
298	R:R:A77	R:R:I333	1.62	No	No	0	8	6
299	R:R:T132	R:R:V133	1.59	No	Yes	0	4	6
300	R:R:T259	R:R:V249	1.59	No	No	0	4	6
301	R:R:A181	R:R:L135	1.58	No	No	0	4	5
302	R:R:I105	R:R:V104	1.54	No	No	0	5	4
303	R:R:I229	R:R:V225	1.54	No	No	0	4	4
304	R:R:I246	R:R:V242	1.54	No	No	0	8	9
305	R:R:H123	R:R:P124	1.53	Yes	No	0	2	1
306	R:R:I61	R:R:T65	1.52	No	No	0	3	4
307	R:R:A292	R:R:Q217	1.52	No	No	0	4	2
308	R:R:A250	R:R:E263	1.51	No	Yes	0	4	8
309	R:R:G160	R:R:R163	1.5	No	No	0	4	4
310	R:R:L75	R:R:V93	1.49	Yes	No	0	7	7
311	R:R:L75	R:R:V97	1.49	Yes	No	0	7	6
312	R:R:L121	R:R:V112	1.49	Yes	No	0	6	4
313	R:R:I111	R:R:I61	1.47	No	No	0	6	3
314	R:R:I47	R:R:N44	1.42	No	No	0	3	7
315	R:R:K167	R:R:L168	1.41	No	No	0	4	5
316	R:R:L100	R:R:L75	1.38	No	Yes	0	7	7
317	R:R:L240	R:R:L244	1.38	No	No	0	4	1
318	R:R:N331	R:R:Q335	1.32	No	No	0	5	4
319	R:R:I170	R:R:W90	1.17	No	No	0	3	5
320	R:R:I178	R:R:W179	1.17	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P39	7.46	4	3	8
2	R:R:F40	4.784	5	3	5
3	R:R:W59	6.0475	4	0	4
4	R:R:N71	5.26	5	1	9
5	R:R:L75	1.5175	4	0	7
6	R:R:I91	5.526	5	1	8
7	R:R:N94	5.5	4	1	9
8	R:R:L95	2.8075	4	1	9
9	R:R:D99	5.54	4	1	9
10	R:R:N113	5.1825	4	3	6
11	R:R:Q114	5.27	4	0	5
12	R:R:F119	5.144	5	3	8
13	R:R:L121	4.134	5	3	6
14	R:R:H123	3.91	4	3	2
15	R:R:V133	2.325	4	4	6
16	R:R:T139	4.785	4	0	7
17	R:R:W142	5.716	5	2	5
18	R:R:S143	4.126	5	1	8
19	R:R:W152	6.576	5	0	7
20	R:R:P158	7.93	4	0	7
21	R:R:F164	5.12333	6	1	7
22	R:R:W177	7.6675	4	0	9
23	R:R:W179	7.836	5	2	4
24	R:R:W183	10.054	5	2	5
25	R:R:P186	4.6675	4	2	3
26	R:R:W191	5.9475	4	2	5
27	R:R:Y194	6.14571	7	2	6
28	R:R:W195	5.602	5	3	3
29	R:R:P196	6.88	5	3	3
30	R:R:H197	3.87833	6	4	3
31	R:R:T201	4.3925	4	0	6
32	R:R:C203	5.0425	4	3	9
33	R:R:F208	6.068	5	4	5
34	R:R:Y213	5.4525	4	0	3
35	R:R:Y219	7.22667	6	2	6
36	R:R:C227	4.59	5	2	5
37	R:R:Y239	5.356	5	1	9
38	R:R:W243	5.8925	4	6	6
39	R:R:E263	3.948	5	6	8
40	R:R:Y277	5.6975	4	0	9
41	R:R:W281	5.31	4	0	8
42	R:R:Y284	8.015	4	4	7
43	R:R:N294	4.165	4	0	4
44	R:R:F299	4.7125	4	0	4
45	R:R:P307	4.152	5	4	6
46	R:R:T315	4.85	4	1	9
47	R:R:Y322	6.96	5	1	9
48	R:R:F324	3.2425	4	1	6
49	R:R:F329	7.846	5	5	8
50	L:L:?1	6.25286	7	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N113	R:R:T201	20.1201	2.92	Yes	Yes	0	6	6
2	R:R:L199	R:R:T201	10.82	2.95	No	Yes	0	5	6
3	R:R:S202	R:R:T201	35.9562	3.2	No	Yes	0	5	6
4	R:R:H197	R:R:S202	37.0401	2.79	Yes	No	0	3	5
5	R:R:Q114	R:R:T201	11.6303	8.5	Yes	Yes	0	5	6
6	R:R:P205	R:R:Y194	13.1831	2.78	No	Yes	0	5	6
7	L:L:?1	R:R:P205	12.9095	7.64	Yes	No	0	0	5
8	L:L:?1	R:R:W281	74.7691	5.3	Yes	Yes	0	0	8
9	R:R:L141	R:R:W281	75.9373	6.83	No	Yes	0	8	8
10	R:R:L141	R:R:Y277	76.2417	8.21	No	Yes	0	8	9
11	R:R:I235	R:R:Y277	100	2.42	No	Yes	0	8	9
12	R:R:I235	R:R:Y239	80.1575	2.42	No	Yes	1	8	9
13	R:R:R151	R:R:Y239	50.3692	8.23	No	Yes	1	9	9
14	R:R:R151	R:R:Y322	37.1902	6.17	No	Yes	1	9	9
15	R:R:L144	R:R:Y322	72.3485	9.38	No	Yes	1	8	9
16	R:R:L144	R:R:L95	35.911	2.77	No	Yes	1	8	9
17	R:R:D99	R:R:L95	41.6387	2.71	Yes	Yes	1	9	9
18	R:R:D99	R:R:T315	10.1783	8.67	Yes	Yes	1	9	9
19	R:R:M273	R:R:Y239	38.7965	5.99	No	Yes	0	8	9
20	R:R:M273	R:R:Y322	38.0602	9.58	No	Yes	0	8	9
21	R:R:L144	R:R:N318	35.7156	4.12	No	No	1	8	9
22	R:R:D99	R:R:N318	34.9012	5.39	Yes	No	1	9	9
23	R:R:D99	R:R:N71	65.1523	5.39	Yes	Yes	1	9	9
24	R:R:L100	R:R:N71	18.2486	6.87	No	Yes	0	7	9
25	R:R:F324	R:R:P319	12.202	2.89	Yes	No	1	6	9
26	R:R:N71	R:R:P319	14.2073	6.52	Yes	No	1	9	9
27	R:R:A96	R:R:N71	30.0948	3.13	No	Yes	0	9	9
28	R:R:A96	R:R:V74	28.1081	3.39	No	No	0	9	9
29	R:R:V323	R:R:V74	26.1173	9.62	No	No	0	7	9
30	R:R:L100	R:R:L75	14.2176	1.38	No	Yes	0	7	7
31	R:R:C332	R:R:L84	10.168	6.35	No	No	0	6	8
32	R:R:F329	R:R:L84	12.1897	17.05	Yes	No	0	8	8
33	R:R:F329	R:R:V323	20.079	5.24	Yes	No	5	8	7
34	R:R:I235	R:R:S148	20.0008	6.19	No	No	1	8	9
35	R:R:C238	R:R:S148	28.3693	5.16	No	No	0	7	9
36	R:R:C238	R:R:W152	27.6968	5.22	No	Yes	0	7	7
37	R:R:F164	R:R:M153	15.4001	3.73	Yes	No	0	7	4
38	R:R:P158	R:R:W152	10.1783	10.81	Yes	Yes	0	7	7
39	R:R:I147	R:R:R151	12.9609	6.26	No	No	1	9	9
40	R:R:I147	R:R:I91	13.3291	7.36	No	Yes	1	9	8
41	R:R:E150	R:R:I91	13.3743	6.83	No	Yes	1	8	8
42	R:R:E150	R:R:F164	11.8977	12.83	No	Yes	1	8	7
43	R:R:C227	R:R:L223	15.2685	3.17	Yes	No	2	5	5
44	R:R:L223	R:R:Y219	16.4655	9.38	No	Yes	2	5	6
45	R:R:S192	R:R:Y219	20.1798	5.09	No	Yes	0	6	6
46	R:R:S192	R:R:V216	16.7616	8.08	No	No	0	6	4
47	R:R:V216	R:R:Y213	15.7827	3.79	No	Yes	0	4	3
48	R:R:C227	R:R:W142	18.6105	2.61	Yes	Yes	2	5	5
49	R:R:P231	R:R:W142	24.1881	10.81	No	Yes	0	9	5
50	R:R:Q241	R:R:W152	20.2106	6.57	No	Yes	0	4	7
51	R:R:L244	R:R:Q241	19.1741	3.99	No	No	0	1	4
52	R:R:L244	R:R:W243	17.0886	3.42	No	Yes	0	1	6
53	R:R:E263	R:R:W243	12.854	5.45	Yes	Yes	6	8	6
54	R:R:H197	R:R:Y284	36.7419	3.27	Yes	Yes	4	3	7
55	L:L:?1	R:R:Y284	50.6859	16.37	Yes	Yes	4	0	7
56	R:R:M220	R:R:Y219	17.4568	5.99	No	Yes	0	5	6
57	L:L:?1	R:R:M220	19.2995	2.82	Yes	No	0	0	5
58	R:R:P231	R:R:Y277	25.4262	2.78	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K312	R:R:V133	3.04	4	No	Yes	8	6	1	1
L:L:?1	R:R:V133	2.97	4	Yes	Yes	0	6	0	1
R:R:L141	R:R:W281	6.83	0	No	Yes	8	8	2	1
R:R:P205	R:R:Y194	2.78	0	No	Yes	5	6	1	2
R:R:G204	R:R:H197	3.18	0	No	Yes	4	3	2	2
R:R:F208	R:R:H197	7.92	4	Yes	Yes	5	3	2	2
R:R:H197	R:R:Y284	3.27	4	Yes	Yes	3	7	2	1
R:R:G204	R:R:P205	4.06	0	No	No	4	5	2	1
L:L:?1	R:R:P205	7.64	4	Yes	No	0	5	0	1
R:R:M220	R:R:V207	7.61	0	No	No	5	4	1	2
R:R:F208	R:R:Y284	8.25	4	Yes	Yes	5	7	2	1
R:R:F208	R:R:P307	4.33	4	Yes	Yes	5	6	2	2
R:R:M220	R:R:Y219	5.99	0	No	Yes	5	6	1	2
L:L:?1	R:R:M220	2.82	4	Yes	No	0	5	0	1
R:R:C280	R:R:W281	5.22	0	No	Yes	8	8	2	1
R:R:A311	R:R:W281	3.89	0	No	Yes	7	8	2	1
L:L:?1	R:R:W281	5.3	4	Yes	Yes	0	8	0	1
R:R:P307	R:R:Y284	4.17	4	Yes	Yes	6	7	2	1
L:L:?1	R:R:Y284	16.37	4	Yes	Yes	0	7	0	1
L:L:?1	R:R:K312	6.56	4	Yes	No	0	8	0	1
L:L:?1	R:R:C228	2.11	4	Yes	No	0	8	0	1
R:R:A106	R:R:V133	1.7	0	No	Yes	6	6	2	1
R:R:T132	R:R:V133	1.59	0	No	Yes	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IU2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.42
Number of Linked Nodes	272
Number of Links	320
Number of Hubs	50
Number of Links mediated by Hubs	189
Number of Communities	8
Number of Nodes involved in Communities	75
Number of Links involved in Communities	103

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	77166
Length Of Smallest Path	3
Average Path Length	15.5867
Length of Longest Path	31
Minimum Path Strength	1.495
Average Path Strength	5.56074
Maximum Path Strength	14.605
Minimum Path Correlation	0.7
Average Path Correlation	0.928124
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	45.2869
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.374
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of cytokinesis • regulation of biological process • regulation of cellular process • positive regulation of cell division • regulation of cell cycle process • biological regulation • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cellular process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • cellular response to stimulus • response to light stimulus • response to stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • multicellular organismal process • sensory perception of light stimulus • system process • sensory perception • nervous system process • visual perception • phototransduction • detection of light stimulus • detection of external stimulus • signaling • response to external stimulus • detection of abiotic stimulus • cell communication • detection of stimulus • signal transduction • G protein-coupled receptor signaling pathway • membrane-bounded organelle • non-motile cilium • membrane • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • cellular anatomical structure • photoreceptor cell cilium • organelle • organelle membrane
Gene Ontology	Cellular Component	• membrane-bounded organelle • non-motile cilium • membrane • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • cellular anatomical structure • photoreceptor cell cilium • organelle • organelle membrane • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • synapse • cell junction • G-protein beta-subunit binding
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	RET
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	RET
Name	RETINAL
Synonyms
Identifier
Formula	C20 H28 O
Molecular Weight	284.436
SMILES
PubChem	638015
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P04000
Sequence	>8IU2_nogp_Chain_R G P F E G P N Y H I A P R W V Y H L T S V W M I F V V T A S V F T N G L V L A A T M K F K K L R H P L N W I L V N L A V A D L A E T V I A S T I S I V N Q V S G Y F V L G H P M C V L Q G Y T V S L C G I T G L W S L A I I S W E R W M V V C K P F G N V R F D A K L A I V G I A F S W I W A A V W T A P P I F G W S R Y W P H G L K T S C G P D V F S G S S Y P G V Q S Y M I V L M V T C C I I P L A I I M L C Y L Q V W L A I R A V A K Q Q K E S E S T Q K A E K E V T R M V V V M I F A Y C V C W G P Y T F F A C F A A A N P G Y A F H P L M A A L P A Y F A K S A T I Y N P V I Y V F M N R Q F R N C I L Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IU2	A	Sensory	Opsins	Opsin1LW	Homo sapiens	Retinal	-	Gi1/β1/γ2	3.35	2024-03-27	To be published
	8IU2 (No Gprot)	A	Sensory	Opsins	Opsin1LW	Homo sapiens	Retinal	-		3.35	2024-03-27	To be published

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Download 8IU2_nogp.zip

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