psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H14	R:R:N13	3.83	No	No	0	5	4
2	R:R:H14	R:R:W15	8.46	No	No	0	5	2
3	R:R:L16	R:R:W15	4.56	No	No	0	6	2
4	R:R:L263	R:R:V17	2.98	No	No	0	5	6
5	R:R:F18	R:R:L22	3.65	No	No	0	6	4
6	R:R:L263	R:R:V20	5.96	No	No	0	5	4
7	R:R:L68	R:R:Y21	5.86	No	Yes	2	7	7
8	R:R:R71	R:R:Y21	5.14	Yes	Yes	2	6	7
9	R:R:M72	R:R:Y21	8.38	No	Yes	0	7	7
10	R:R:T266	R:R:Y21	4.99	No	Yes	0	7	7
11	R:R:F23	R:R:L22	6.09	No	No	0	4	4
12	R:R:T24	R:R:T266	3.14	No	No	0	7	7
13	R:R:L267	R:R:T24	2.95	No	No	0	5	7
14	R:R:C270	R:R:T24	3.38	No	No	0	7	7
15	R:R:F25	R:R:L29	8.53	No	No	0	7	6
16	R:R:F25	R:R:P69	7.22	No	No	0	7	9
17	R:R:L31	R:R:P273	9.85	No	No	0	7	9
18	R:R:L62	R:R:N32	4.12	No	No	0	7	9
19	R:R:N32	R:R:P273	4.89	No	No	0	9	9
20	R:R:F287	R:R:L34	7.31	No	No	0	6	5
21	R:R:L36	R:R:T58	2.95	No	Yes	0	7	9
22	R:R:L36	R:R:L62	4.15	No	No	0	7	7
23	R:R:F283	R:R:I38	5.02	No	Yes	0	8	7
24	R:R:D286	R:R:I38	5.6	No	Yes	0	5	7
25	R:R:I38	R:R:L290	5.71	Yes	No	0	7	5
26	R:R:F39	R:R:L54	6.09	Yes	Yes	1	7	8
27	R:R:F39	R:R:L55	3.65	Yes	No	1	7	6
28	R:R:F39	R:R:T58	3.89	Yes	Yes	1	7	9
29	R:R:F39	R:R:Y276	7.22	Yes	Yes	1	7	9
30	R:R:F283	R:R:F39	5.36	No	Yes	0	8	7
31	R:R:G41	R:R:R44	3	No	No	0	4	6
32	R:R:K42	R:R:R45	4.95	No	No	0	5	6
33	R:R:D51	R:R:K42	4.15	No	No	0	7	5
34	R:R:D286	R:R:K42	11.06	No	No	0	5	5
35	R:R:R45	R:R:R46	11.73	No	No	0	6	4
36	R:R:L129	R:R:P47	4.93	No	No	0	3	5
37	R:R:V48	R:R:V50	4.81	No	No	0	7	8
38	R:R:D51	R:R:V48	4.38	No	No	0	7	7
39	R:R:V48	R:R:Y123	3.79	No	No	0	7	5
40	R:R:A49	R:R:E112	6.03	No	No	0	6	8
41	R:R:L54	R:R:V50	2.98	Yes	No	0	8	8
42	R:R:L53	R:R:V109	2.98	Yes	No	0	8	8
43	R:R:E112	R:R:L53	9.28	No	Yes	0	8	8
44	R:R:L53	R:R:S136	3	Yes	Yes	0	8	6
45	R:R:L54	R:R:V109	2.98	Yes	No	0	8	8
46	R:R:L54	R:R:Y276	8.21	Yes	Yes	1	8	9
47	R:R:L55	R:R:T58	4.42	No	Yes	1	6	9
48	R:R:L59	R:R:N56	4.12	No	Yes	0	5	9
49	R:R:F105	R:R:N56	7.25	Yes	Yes	4	7	9
50	R:R:N56	R:R:S136	4.47	Yes	Yes	0	9	6
51	R:R:N56	R:R:W140	7.91	Yes	Yes	4	9	9
52	R:R:F105	R:R:L57	8.53	Yes	No	0	7	9
53	R:R:L57	R:R:Y276	4.69	No	Yes	0	9	9
54	R:R:T58	R:R:Y276	3.75	Yes	Yes	1	9	9
55	R:R:S60	R:R:T98	3.2	No	No	0	8	9
56	R:R:L101	R:R:S60	4.5	No	No	4	7	8
57	R:R:S60	R:R:W140	4.94	No	Yes	4	8	9
58	R:R:D61	R:R:S269	8.83	No	No	0	9	8
59	R:R:D272	R:R:D61	5.32	No	No	0	9	9
60	R:R:L63	R:R:L94	6.92	No	Yes	0	7	5
61	R:R:L64	R:R:L65	4.15	Yes	No	6	6	5
62	R:R:F95	R:R:L64	4.87	Yes	Yes	0	6	6
63	R:R:L64	R:R:T98	13.27	Yes	No	0	6	9
64	R:R:L64	R:R:S269	3	Yes	No	6	6	8
65	R:R:L65	R:R:S269	3	No	No	6	5	8
66	R:R:F67	R:R:L66	3.65	No	No	0	6	5
67	R:R:F67	R:R:L94	6.09	No	Yes	0	6	5
68	R:R:L68	R:R:R71	3.64	No	Yes	2	7	6
69	R:R:F70	R:R:L87	3.65	No	No	0	6	5
70	R:R:F70	R:R:S91	5.28	No	No	0	6	5
71	R:R:R71	R:R:W81	5	Yes	No	2	6	9
72	R:R:R71	R:R:S91	5.27	Yes	No	0	6	5
73	R:R:F95	R:R:R71	11.76	Yes	Yes	0	6	6
74	R:R:E74	R:R:P82	7.86	No	No	0	5	4
75	R:R:L171	R:R:M79	7.07	No	No	0	4	5
76	R:R:H80	R:R:T165	8.21	No	No	0	4	5
77	R:R:G167	R:R:H80	3.18	No	No	0	4	4
78	R:R:H80	R:R:T168	4.11	No	No	0	4	4
79	R:R:C88	R:R:W81	13.06	No	No	2	9	9
80	R:R:C169	R:R:W81	10.45	Yes	No	2	9	9
81	R:R:L83	R:R:P84	4.93	No	No	7	7	8
82	R:R:L83	R:R:L87	4.15	No	No	7	7	5
83	R:R:L87	R:R:P84	3.28	No	No	7	5	8
84	R:R:C169	R:R:C88	7.28	Yes	No	2	9	9
85	R:R:C88	R:R:Y170	6.72	No	No	2	9	4
86	R:R:G92	R:R:S91	3.71	No	No	0	5	5
87	R:R:G92	R:R:Y170	5.79	No	No	0	5	4
88	R:R:F93	R:R:L94	7.31	Yes	Yes	0	5	5
89	R:R:C147	R:R:F93	9.78	No	Yes	0	6	5
90	R:R:F93	R:R:Y151	9.28	Yes	No	0	5	5
91	R:R:F95	R:R:F96	5.36	Yes	No	0	6	5
92	R:R:F95	R:R:L262	7.31	Yes	No	0	6	5
93	L:L:?1	R:R:F96	24.17	Yes	No	0	0	5
94	R:R:C147	R:R:T97	5.07	No	No	0	6	4
95	R:R:I99	R:R:Y100	3.63	No	Yes	0	7	7
96	R:R:F238	R:R:I99	5.02	Yes	No	0	8	7
97	R:R:I99	R:R:S265	4.64	No	No	0	7	7
98	R:R:M188	R:R:Y100	8.38	No	Yes	3	6	7
99	R:R:L192	R:R:Y100	8.21	Yes	Yes	0	6	7
100	R:R:Y100	R:R:Y241	13.9	Yes	No	3	7	6
101	L:L:?1	R:R:Y100	6.84	Yes	Yes	3	0	7
102	R:R:F105	R:R:L101	13.4	Yes	No	4	7	7
103	R:R:L101	R:R:W140	10.25	No	Yes	4	7	9
104	R:R:F238	R:R:T102	3.89	Yes	No	0	8	9
105	R:R:A103	R:R:P196	3.74	No	Yes	0	7	9
106	R:R:C139	R:R:L104	4.76	No	No	0	7	5
107	R:R:L104	R:R:L192	4.15	No	Yes	0	5	6
108	R:R:F105	R:R:W140	8.02	Yes	Yes	4	7	9
109	R:R:L106	W:W:?1	15.32	No	Yes	0	8	0
110	R:R:S110	R:R:T200	9.59	No	No	1	9	8
111	R:R:C203	R:R:S110	5.16	No	No	0	7	9
112	R:R:S110	R:R:Y204	10.17	No	Yes	1	9	8
113	R:R:C203	R:R:I111	3.27	No	No	0	7	6
114	R:R:R113	R:R:Y204	8.23	No	Yes	1	9	8
115	R:R:R113	W:W:?1	10.61	No	Yes	1	9	0
116	R:R:A118	R:R:F114	5.55	No	Yes	0	7	8
117	R:R:C203	R:R:F114	5.59	No	Yes	0	7	8
118	R:R:F114	R:R:R206	8.55	Yes	No	0	8	5
119	R:R:L115	R:R:W122	3.42	No	No	0	5	5
120	R:R:L207	R:R:V117	4.47	No	No	1	8	8
121	R:R:L211	R:R:V117	4.47	Yes	No	1	8	8
122	R:R:R126	R:R:W122	10	No	No	0	4	5
123	R:R:R128	R:R:W122	13.99	No	No	0	5	5
124	R:R:R126	R:R:T125	3.88	No	No	0	4	4
125	R:R:Q131	R:R:R128	26.87	No	No	0	3	5
126	R:R:H146	R:R:M188	3.94	No	No	0	4	6
127	R:R:H146	R:R:L192	5.14	No	Yes	0	4	6
128	L:L:?1	R:R:C147	3.71	Yes	No	0	0	6
129	R:R:S148	R:R:Y151	7.63	No	No	0	4	5
130	R:R:V149	R:R:V184	3.21	No	No	0	7	4
131	L:L:?1	R:R:V150	10.44	Yes	No	0	0	4
132	R:R:I153	R:R:V152	3.07	No	No	0	4	4
133	R:R:F155	R:R:S156	11.89	No	No	0	4	4
134	R:R:D158	R:R:S156	5.89	No	No	0	1	4
135	R:R:G157	R:R:R174	3	No	No	0	1	5
136	R:R:L171	R:R:T168	10.32	No	No	0	4	4
137	R:R:C169	R:R:Y170	10.75	Yes	No	2	9	4
138	R:R:F173	R:R:Q177	7.03	No	Yes	5	5	3
139	R:R:F173	R:R:L178	3.65	No	No	5	5	3
140	R:R:D176	R:R:R174	3.57	No	No	5	2	5
141	R:R:Q177	R:R:R174	9.35	Yes	No	5	3	5
142	R:R:D176	R:R:Q177	11.75	No	Yes	5	2	3
143	R:R:L178	R:R:Q177	3.99	No	Yes	5	3	3
144	R:R:L181	R:R:R185	3.64	No	Yes	0	4	5
145	R:R:L182	R:R:Y249	8.21	No	No	0	2	5
146	R:R:E187	R:R:V184	4.28	No	No	0	3	4
147	R:R:H245	R:R:R185	12.41	No	Yes	3	5	5
148	R:R:R185	R:R:R258	7.46	Yes	No	3	5	4
149	L:L:?1	R:R:R185	21.28	Yes	Yes	3	0	5
150	R:R:L186	R:R:V190	2.98	No	No	0	4	4
151	R:R:L186	R:R:Y249	9.38	No	No	0	4	5
152	L:L:?1	R:R:M188	9.9	Yes	No	3	0	6
153	R:R:A189	R:R:H245	7.32	No	No	0	5	5
154	R:R:F193	R:R:L197	6.09	Yes	Yes	1	8	6
155	R:R:F193	R:R:F234	6.43	Yes	Yes	1	8	9
156	R:R:F193	R:R:F238	3.22	Yes	Yes	1	8	8
157	R:R:F193	R:R:N242	29	Yes	No	0	8	8
158	R:R:P196	R:R:V195	3.53	Yes	No	0	9	5
159	R:R:I199	R:R:V195	3.07	No	No	0	6	5
160	R:R:F234	R:R:L197	3.65	Yes	Yes	1	9	6
161	R:R:L197	W:W:?1	4.03	Yes	Yes	1	6	0
162	R:R:T200	R:R:Y204	4.99	No	Yes	1	8	8
163	R:R:T200	W:W:?1	12.88	No	Yes	1	8	0
164	R:R:R206	R:R:Y202	16.46	No	No	0	5	4
165	R:R:V227	R:R:Y204	5.05	No	Yes	0	7	8
166	R:R:Y204	W:W:?1	16.39	Yes	Yes	1	8	0
167	R:R:L207	R:R:L211	4.15	No	Yes	1	8	8
168	R:R:R213	R:R:W209	10	No	No	0	4	3
169	R:R:L211	R:R:R219	3.64	Yes	No	0	8	5
170	R:R:L211	R:R:V223	4.47	Yes	No	0	8	8
171	R:R:G212	R:R:R220	7.51	No	No	0	4	7
172	R:R:A215	R:R:R220	4.15	No	No	0	3	7
173	R:R:R218	R:R:S216	7.91	No	No	0	4	3
174	R:R:R219	R:R:S216	3.95	No	No	0	5	3
175	R:R:H217	R:R:R221	5.64	No	No	0	4	5
176	R:R:R219	R:R:R220	4.26	No	No	0	5	7
177	R:R:L226	R:R:S279	3	No	No	0	7	6
178	R:R:T230	W:W:?1	29.19	No	Yes	0	7	0
179	R:R:L231	R:R:L235	4.15	No	No	0	7	5
180	R:R:L231	W:W:?1	4.84	No	Yes	0	7	0
181	R:R:C237	R:R:N233	4.72	No	No	0	8	6
182	R:R:N233	R:R:V271	7.39	No	No	0	6	7
183	R:R:F234	R:R:F238	5.36	Yes	Yes	1	9	8
184	R:R:F234	W:W:?1	11.35	Yes	Yes	1	9	0
185	R:R:C237	R:R:N268	7.87	No	No	0	8	9
186	R:R:F238	R:R:N268	7.25	Yes	No	0	8	9
187	R:R:G239	R:R:P240	4.06	No	No	0	5	9
188	R:R:P240	R:R:Y260	6.95	No	Yes	8	9	4
189	R:R:L264	R:R:P240	4.93	No	No	8	7	9
190	R:R:V261	R:R:Y241	6.31	No	No	0	6	6
191	L:L:?1	R:R:Y241	15.06	Yes	No	3	0	6
192	R:R:S244	R:R:W257	7.41	No	Yes	0	4	4
193	L:L:?1	R:R:H245	12.01	Yes	No	3	0	5
194	R:R:Q251	R:R:V247	4.3	No	No	0	1	5
195	R:R:E253	R:R:Q251	15.29	No	No	0	1	1
196	R:R:P255	R:R:S254	3.56	No	No	0	4	6
197	L:L:?1	R:R:R258	5.67	Yes	No	3	0	4
198	R:R:V261	R:R:Y260	8.83	No	Yes	0	6	4
199	R:R:L264	R:R:Y260	4.69	No	Yes	8	7	4
200	R:R:L262	R:R:V261	2.98	No	No	0	5	6
201	R:R:D272	R:R:N268	6.73	No	No	0	9	9
202	R:R:D272	W:W:?1	3.16	No	Yes	0	9	0
203	R:R:V275	W:W:?1	4.34	No	Yes	0	7	0
204	R:R:Y276	W:W:?1	6.14	Yes	Yes	1	9	0
205	R:R:Q284	R:R:Y277	4.51	No	No	0	8	7
206	R:R:F287	R:R:Y277	7.22	No	No	0	6	7
207	R:R:F283	R:R:S280	3.96	No	No	0	8	8
208	R:R:D286	R:R:E289	5.2	No	No	0	5	4
209	R:R:F287	R:R:L291	9.74	No	No	0	6	6
210	R:R:I111	R:R:I199	2.94	No	No	0	6	6
211	R:R:I153	R:R:I180	2.94	No	No	0	4	3
212	R:R:W257	R:R:Y260	2.89	Yes	Yes	0	4	4
213	R:R:Q284	R:R:S281	2.89	No	No	0	8	4
214	R:R:P255	R:R:R258	2.88	No	No	0	4	4
215	R:R:I38	R:R:L34	2.85	Yes	No	0	7	5
216	R:R:P89	R:R:Y151	2.78	No	No	0	7	5
217	R:R:L33	R:R:L62	2.77	No	No	0	3	7
218	R:R:L43	R:R:L55	2.77	No	No	0	5	6
219	R:R:A118	R:R:Y119	2.67	No	No	0	7	6
220	R:R:E74	R:R:L83	2.65	No	No	0	5	7
221	R:R:S201	W:W:?1	2.62	No	Yes	0	4	0
222	R:R:F278	R:R:V275	2.62	No	No	0	7	7
223	R:R:S116	R:R:Y123	2.54	No	No	0	7	5
224	R:R:V17	R:R:Y21	2.52	No	Yes	0	6	7
225	R:R:V256	R:R:W257	2.45	No	Yes	0	5	4
226	R:R:F25	R:R:L26	2.44	No	No	0	7	4
227	R:R:F114	R:R:L115	2.44	Yes	No	0	8	5
228	R:R:F278	R:R:L226	2.44	No	No	0	7	7
229	R:R:L207	R:R:Y204	2.34	No	Yes	1	8	8
230	R:R:E154	R:R:F85	2.33	No	No	0	5	4
231	R:R:H217	R:R:R218	2.26	No	No	0	4	4
232	R:R:Q251	R:R:W257	2.19	No	Yes	0	1	4
233	R:R:G28	R:R:P30	2.03	No	No	0	8	4
234	R:R:G194	R:R:P196	2.03	No	Yes	0	4	9
235	R:R:G248	R:R:P255	2.03	No	No	0	5	4
236	R:R:F18	R:R:W15	2	No	No	0	6	2
237	R:R:C270	R:R:G28	1.96	No	No	0	7	8
238	R:R:A132	R:R:G133	1.95	No	No	0	7	4
239	R:R:A285	R:R:G282	1.95	No	No	0	4	7
240	R:R:A107	R:R:P196	1.87	No	Yes	0	7	9
241	R:R:G133	R:R:S136	1.86	No	Yes	0	4	6
242	R:R:G157	R:R:S156	1.86	No	No	0	1	4
243	R:R:G282	R:R:S280	1.86	No	No	0	7	8
244	R:R:G28	R:R:V27	1.84	No	No	0	8	5
245	R:R:A75	R:R:S77	1.71	No	No	0	5	3
246	R:R:G130	R:R:L129	1.71	No	No	0	3	3
247	R:R:A132	R:R:V52	1.7	No	No	0	7	7
248	R:R:I86	R:R:P84	1.69	No	No	0	2	8
249	R:R:A143	R:R:T97	1.68	No	No	0	7	4
250	R:R:L29	R:R:P30	1.64	No	No	0	6	4
251	R:R:L43	R:R:P47	1.64	No	No	0	5	5
252	R:R:L68	R:R:P69	1.64	No	No	0	7	9
253	R:R:G130	R:R:Q131	1.64	No	No	0	3	3
254	R:R:L182	R:R:P183	1.64	No	No	0	2	3
255	R:R:S259	R:R:V17	1.62	No	No	0	4	6
256	R:R:A118	R:R:I210	1.62	No	No	0	7	5
257	R:R:S136	R:R:V137	1.62	Yes	No	0	6	4
258	R:R:V208	R:R:V223	1.6	No	No	0	4	8
259	R:R:V208	R:R:V227	1.6	No	No	0	4	7
260	R:R:A108	R:R:L53	1.58	No	Yes	0	5	8
261	R:R:I250	R:R:V246	1.54	No	No	0	4	5
262	R:R:C169	R:R:E154	1.52	Yes	No	0	9	5
263	R:R:L141	R:R:S144	1.5	No	No	0	4	3
264	R:R:L53	R:R:V135	1.49	Yes	No	0	8	5
265	R:R:L192	R:R:V191	1.49	Yes	No	0	6	4
266	R:R:A76	R:R:H14	1.46	No	No	0	3	5
267	R:R:P127	R:R:R126	1.44	No	No	0	7	4
268	R:R:E187	R:R:V191	1.43	No	No	0	3	4
269	R:R:L22	R:R:M72	1.41	No	No	0	4	7
270	R:R:P120	R:R:Y119	1.39	No	No	0	8	6
271	R:R:L90	R:R:L94	1.38	No	Yes	0	4	5
272	R:R:L178	R:R:L182	1.38	No	No	0	3	2
273	R:R:L197	R:R:L198	1.38	Yes	No	0	6	3
274	R:R:I153	R:R:Q177	1.37	No	Yes	0	4	3
275	R:R:F18	R:R:S19	1.32	No	No	0	6	3
276	R:R:F93	R:R:S144	1.32	Yes	No	0	5	3
277	R:R:R206	R:R:S205	1.32	No	No	0	5	3
278	R:R:R44	R:R:V40	1.31	No	No	0	6	2
279	R:R:L226	R:R:R222	1.21	No	No	0	7	7
280	R:R:E154	R:R:F173	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y21	5.378	5	2	7
2	R:R:I38	4.795	4	0	7
3	R:R:F39	5.242	5	1	7
4	R:R:L53	3.666	5	0	8
5	R:R:L54	5.065	4	1	8
6	R:R:N56	5.9375	4	4	9
7	R:R:T58	3.7525	4	1	9
8	R:R:L64	6.3225	4	6	6
9	R:R:R71	6.162	5	2	6
10	R:R:F93	6.9225	4	0	5
11	R:R:L94	5.425	4	0	5
12	R:R:F95	7.325	4	0	6
13	R:R:Y100	8.192	5	3	7
14	R:R:F105	9.3	4	4	7
15	R:R:F114	5.5325	4	0	8
16	R:R:S136	2.7375	4	0	6
17	R:R:W140	7.78	4	4	9
18	R:R:C169	7.5	4	2	9
19	R:R:Q177	6.698	5	5	3
20	R:R:R185	11.1975	4	3	5
21	R:R:L192	4.7475	4	0	6
22	R:R:F193	11.185	4	1	8
23	R:R:P196	2.7925	4	0	9
24	R:R:L197	3.7875	4	1	6
25	R:R:Y204	7.86167	6	1	8
26	R:R:L211	4.1825	4	1	8
27	R:R:F234	6.6975	4	1	9
28	R:R:F238	4.948	5	1	8
29	R:R:W257	3.735	4	0	4
30	R:R:Y260	5.84	4	8	4
31	R:R:Y276	6.002	5	1	9
32	W:W:?1	10.0725	12	1	0
33	L:L:?1	12.12	9	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F18	R:R:W15	10.3876	2	No	No	0	6	2
2	R:R:F18	R:R:L22	14.4391	3.65	No	No	0	6	4
3	R:R:L22	R:R:M72	18.4297	1.41	No	No	0	4	7
4	R:R:M72	R:R:Y21	20.4021	8.38	No	Yes	0	7	7
5	R:R:R71	R:R:Y21	39.4182	5.14	Yes	Yes	2	6	7
6	R:R:T266	R:R:Y21	12.3068	4.99	No	Yes	0	7	7
7	R:R:T24	R:R:T266	10.3419	3.14	No	No	0	7	7
8	R:R:L68	R:R:P69	10.2201	1.64	No	No	0	7	9
9	R:R:F95	R:R:R71	100	11.76	Yes	Yes	0	6	6
10	R:R:F95	R:R:L64	84.449	4.87	Yes	Yes	0	6	6
11	R:R:L64	R:R:S269	68.403	3	Yes	No	6	6	8
12	R:R:D61	R:R:S269	69.652	8.83	No	No	0	9	8
13	R:R:D272	R:R:D61	70.0784	5.32	No	No	0	9	9
14	R:R:D272	W:W:?1	72.6906	3.16	No	Yes	0	9	0
15	R:R:Y276	W:W:?1	88.7823	6.14	Yes	Yes	1	9	0
16	R:R:T58	R:R:Y276	20.7981	3.75	Yes	Yes	1	9	9
17	R:R:L36	R:R:T58	13.0607	2.95	No	Yes	0	7	9
18	R:R:L36	R:R:L62	10.9207	4.15	No	No	0	7	7
19	R:R:F287	R:R:L34	10.0525	7.31	No	No	0	6	5
20	R:R:I38	R:R:L34	11.7813	2.85	Yes	No	0	7	5
21	R:R:F283	R:R:I38	24.286	5.02	No	Yes	0	8	7
22	R:R:F283	R:R:F39	31.3381	5.36	No	Yes	0	8	7
23	R:R:F39	R:R:Y276	37.362	7.22	Yes	Yes	1	7	9
24	R:R:L54	R:R:Y276	25.5655	8.21	Yes	Yes	1	8	9
25	R:R:F39	R:R:L55	10.6923	3.65	Yes	No	1	7	6
26	R:R:L54	R:R:V50	14.8884	2.98	Yes	No	0	8	8
27	R:R:V48	R:R:V50	12.9388	4.81	No	No	0	7	8
28	R:R:L43	R:R:L55	16.0079	2.77	No	No	0	5	6
29	R:R:L43	R:R:P47	12.8475	1.64	No	No	0	5	5
30	R:R:L53	R:R:S136	10.578	3	Yes	Yes	0	8	6
31	R:R:N56	R:R:S136	13.6623	4.47	Yes	Yes	0	9	6
32	R:R:N56	R:R:W140	10.9055	7.91	Yes	Yes	4	9	9
33	R:R:S60	R:R:W140	14.4163	4.94	No	Yes	4	8	9
34	R:R:S60	R:R:T98	16.9142	3.2	No	No	0	8	9
35	R:R:L64	R:R:T98	17.6377	13.27	Yes	No	0	6	9
36	R:R:L53	R:R:V109	12.8779	2.98	Yes	No	0	8	8
37	R:R:L54	R:R:V109	13.9669	2.98	Yes	No	0	8	8
38	R:R:F105	R:R:L57	13.6852	8.53	Yes	No	0	7	9
39	R:R:F95	R:R:F96	27.0962	5.36	Yes	No	0	6	5
40	L:L:?1	R:R:F96	26.7611	24.17	Yes	No	0	0	5
41	L:L:?1	R:R:C147	27.911	3.71	Yes	No	0	0	6
42	R:R:C147	R:R:F93	22.0928	9.78	No	Yes	0	6	5
43	R:R:F93	R:R:L94	10.5019	7.31	Yes	Yes	0	5	5
44	R:R:F70	R:R:S91	15.3987	5.28	No	No	0	6	5
45	R:R:R71	R:R:S91	19.6025	5.27	Yes	No	0	6	5
46	R:R:F70	R:R:L87	13.2435	3.65	No	No	0	6	5
47	R:R:R71	R:R:W81	45.0994	5	Yes	No	2	6	9
48	R:R:C169	R:R:W81	39.8142	10.45	Yes	No	2	9	9
49	L:L:?1	R:R:Y100	36.5776	6.84	Yes	Yes	3	0	7
50	R:R:I99	R:R:Y100	56.7512	3.63	No	Yes	0	7	7
51	R:R:F238	R:R:I99	57.4671	5.02	Yes	No	0	8	7
52	R:R:L192	R:R:Y100	16.0536	8.21	Yes	Yes	0	6	7
53	R:R:V261	R:R:Y241	16.1678	6.31	No	No	0	6	6
54	R:R:P196	R:R:V195	14.0355	3.53	Yes	No	0	9	5
55	R:R:I199	R:R:V195	17.5082	3.07	No	No	0	6	5
56	R:R:I111	R:R:I199	20.9657	2.94	No	No	0	6	6
57	R:R:C203	R:R:I111	24.4079	3.27	No	No	0	7	6
58	R:R:C203	R:R:S110	74.0309	5.16	No	No	0	7	9
59	R:R:S110	R:R:T200	37.004	9.59	No	No	1	9	8
60	R:R:T200	W:W:?1	38.2301	12.88	No	Yes	1	8	0
61	R:R:S110	R:R:Y204	40.195	10.17	No	Yes	1	9	8
62	R:R:Y204	W:W:?1	61.8917	16.39	Yes	Yes	1	8	0
63	R:R:A118	R:R:F114	13.7461	5.55	No	Yes	0	7	8
64	R:R:C203	R:R:F114	48.3817	5.59	No	Yes	0	7	8
65	R:R:F114	R:R:R206	10.479	8.55	Yes	No	0	8	5
66	R:R:F114	R:R:L115	22.2298	2.44	Yes	No	0	8	5
67	R:R:L115	R:R:W122	18.9095	3.42	No	No	0	5	5
68	R:R:L207	R:R:Y204	21.5977	2.34	No	Yes	1	8	8
69	R:R:L207	R:R:L211	18.1098	4.15	No	Yes	1	8	8
70	R:R:R126	R:R:W122	10.8903	10	No	No	0	4	5
71	R:R:C169	R:R:E154	37.7351	1.52	Yes	No	0	9	5
72	R:R:E154	R:R:F173	34.1939	1.17	No	No	0	5	5
73	R:R:F173	R:R:Q177	20.0899	7.03	No	Yes	5	5	3
74	R:R:Q177	R:R:R174	10.3039	9.35	Yes	No	5	3	5
75	R:R:F173	R:R:L178	12.1925	3.65	No	No	5	5	3
76	R:R:L178	R:R:L182	10.578	1.38	No	No	0	3	2
77	R:R:F234	R:R:F238	53.545	5.36	Yes	Yes	1	9	8
78	R:R:F234	W:W:?1	55.7612	11.35	Yes	Yes	1	9	0
79	R:R:L211	R:R:R219	14.9037	3.64	Yes	No	0	8	5
80	R:R:V275	W:W:?1	10.1363	4.34	No	Yes	0	7	0
81	R:R:V261	R:R:Y260	20.7067	8.83	No	Yes	0	6	4
82	R:R:W257	R:R:Y260	12.6038	2.89	Yes	Yes	0	4	4
83	R:R:L68	R:R:R71	11.4157	3.64	No	Yes	2	7	6
84	R:R:L57	R:R:Y276	13.7004	4.69	No	Yes	0	9	9
85	R:R:Y100	R:R:Y241	14.2259	13.9	Yes	No	3	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C147	R:R:F93	9.78	0	No	Yes	6	5	1	2
R:R:F95	R:R:F96	5.36	0	Yes	No	6	5	2	1
L:L:?1	R:R:F96	24.17	3	Yes	No	0	5	0	1
R:R:C147	R:R:T97	5.07	0	No	No	6	4	1	2
R:R:I99	R:R:Y100	3.63	0	No	Yes	7	7	2	1
R:R:M188	R:R:Y100	8.38	3	No	Yes	6	7	1	1
R:R:L192	R:R:Y100	8.21	0	Yes	Yes	6	7	2	1
R:R:Y100	R:R:Y241	13.9	3	Yes	No	7	6	1	1
L:L:?1	R:R:Y100	6.84	3	Yes	Yes	0	7	0	1
R:R:H146	R:R:M188	3.94	0	No	No	4	6	2	1
R:R:H146	R:R:L192	5.14	0	No	Yes	4	6	2	2
L:L:?1	R:R:C147	3.71	3	Yes	No	0	6	0	1
L:L:?1	R:R:V150	10.44	3	Yes	No	0	4	0	1
R:R:L181	R:R:R185	3.64	0	No	Yes	4	5	2	1
R:R:H245	R:R:R185	12.41	3	No	Yes	5	5	1	1
R:R:R185	R:R:R258	7.46	3	Yes	No	5	4	1	1
L:L:?1	R:R:R185	21.28	3	Yes	Yes	0	5	0	1
L:L:?1	R:R:M188	9.9	3	Yes	No	0	6	0	1
R:R:A189	R:R:H245	7.32	0	No	No	5	5	2	1
R:R:V261	R:R:Y241	6.31	0	No	No	6	6	2	1
L:L:?1	R:R:Y241	15.06	3	Yes	No	0	6	0	1
L:L:?1	R:R:H245	12.01	3	Yes	No	0	5	0	1
L:L:?1	R:R:R258	5.67	3	Yes	No	0	4	0	1
R:R:P255	R:R:R258	2.88	0	No	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F39	R:R:L54	6.09	1	Yes	Yes	7	8	2	2
R:R:F39	R:R:T58	3.89	1	Yes	Yes	7	9	2	2
R:R:F39	R:R:Y276	7.22	1	Yes	Yes	7	9	2	1
R:R:L54	R:R:Y276	8.21	1	Yes	Yes	8	9	2	1
R:R:L57	R:R:Y276	4.69	0	No	Yes	9	9	2	1
R:R:T58	R:R:Y276	3.75	1	Yes	Yes	9	9	2	1
R:R:D272	R:R:D61	5.32	0	No	No	9	9	1	2
R:R:L106	W:W:?1	15.32	0	No	Yes	8	0	1	0
R:R:S110	R:R:T200	9.59	1	No	No	9	8	2	1
R:R:S110	R:R:Y204	10.17	1	No	Yes	9	8	2	1
R:R:R113	R:R:Y204	8.23	1	No	Yes	9	8	1	1
R:R:R113	W:W:?1	10.61	1	No	Yes	9	0	1	0
R:R:F193	R:R:L197	6.09	1	Yes	Yes	8	6	2	1
R:R:F193	R:R:F234	6.43	1	Yes	Yes	8	9	2	1
R:R:F193	R:R:F238	3.22	1	Yes	Yes	8	8	2	2
R:R:F234	R:R:L197	3.65	1	Yes	Yes	9	6	1	1
R:R:L197	W:W:?1	4.03	1	Yes	Yes	6	0	1	0
R:R:T200	R:R:Y204	4.99	1	No	Yes	8	8	1	1
R:R:T200	W:W:?1	12.88	1	No	Yes	8	0	1	0
R:R:V227	R:R:Y204	5.05	0	No	Yes	7	8	2	1
R:R:Y204	W:W:?1	16.39	1	Yes	Yes	8	0	1	0
R:R:T230	W:W:?1	29.19	0	No	Yes	7	0	1	0
R:R:L231	R:R:L235	4.15	0	No	No	7	5	1	2
R:R:L231	W:W:?1	4.84	0	No	Yes	7	0	1	0
R:R:F234	R:R:F238	5.36	1	Yes	Yes	9	8	1	2
R:R:F234	W:W:?1	11.35	1	Yes	Yes	9	0	1	0
R:R:F238	R:R:N268	7.25	1	Yes	No	8	9	2	2
R:R:D272	R:R:N268	6.73	0	No	No	9	9	1	2
R:R:D272	W:W:?1	3.16	0	No	Yes	9	0	1	0
R:R:V275	W:W:?1	4.34	0	No	Yes	7	0	1	0
R:R:Y276	W:W:?1	6.14	1	Yes	Yes	9	0	1	0
R:R:S201	W:W:?1	2.62	0	No	Yes	4	0	1	0
R:R:F278	R:R:V275	2.62	0	No	No	7	7	2	1
R:R:L207	R:R:Y204	2.34	1	No	Yes	8	8	2	1
R:R:L197	R:R:L198	1.38	1	Yes	No	6	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8J20_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	250
Number of Links	280
Number of Hubs	33
Number of Links mediated by Hubs	128
Number of Communities	8
Number of Nodes involved in Communities	50
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	36265
Length Of Smallest Path	3
Average Path Length	11.7774
Length of Longest Path	25
Minimum Path Strength	1.345
Average Path Strength	6.22014
Maximum Path Strength	22.79
Minimum Path Correlation	0.7
Average Path Correlation	0.923974
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	50.7827
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6741
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • lipid binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • multicellular organismal process • positive regulation of macromolecule biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • immune response • mucosal immune response • organ or tissue specific immune response • regulation of defense response • regulation of response to external stimulus • positive regulation of acute inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • response to stress • regulation of response to stress • regulation of acute inflammatory response to non-antigenic stimulus • acute inflammatory response • defense response • acute inflammatory response to non-antigenic stimulus • response to external stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response to non-antigenic stimulus • regulation of response to stimulus • positive regulation of defense response • regulation of acute inflammatory response • inflammatory response • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • regulation of cell communication • hormone transport • response to fatty acid • cellular response to fatty acid • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • catecholamine transport • norepinephrine transport • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • regulation of hormone biosynthetic process • regulation of hormone metabolic process • hormone metabolic process • hormone biosynthetic process • regulation of immune effector process • positive regulation of immune effector process • regulation of immune system process • cytokine production involved in immune response • positive regulation of immune system process • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune effector process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • system process • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • regulation of signal transduction • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • cell surface receptor signaling pathway • regulation of insulin receptor signaling pathway • cellular response to peptide hormone stimulus • response to insulin • cellular response to insulin stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9T4
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	9T4
Name	(4R)-N-[2,5-bis(chloranyl)phenyl]-4-(furan-2-yl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
Synonyms
Identifier
Formula	C21 H18 Cl2 N2 O3
Molecular Weight	417.285
SMILES
PubChem	124893090
Formal Charge	0
Total Atoms	46
Total Chiral Atoms	1
Total Bonds	49
Total Aromatic Bonds	11


Code	LEA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	LEA
Name	N-Valeric Acid
Synonyms	VALERIC ACID
Identifier
Formula	C5 H10 O2
Molecular Weight	102.132
SMILES
PubChem	7991
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	16
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O14843
Sequence	>8J20_nogp_Chain_R N H W L V F S V Y L F T F L V G L P L N L L A L V I F V G K L R R R P V A V D V L L L N L T L S D L L L L L F L P F R M V E A A S G M H W P L P F I L C P L S G F L F F T T I Y L T A L F L A A V S I E R F L S V A Y P L W Y K T R P R L G Q A G L V S V A C W L L A S A H C S V V Y V I E F S G D T N G T C Y L E F R E D Q L A I L L P V R L E M A V V L F G V P L L I T S Y C Y S R L V W I L G R G A S H R R R R R V A G L V A A T L L N F L V C F G P Y N V S H V V G Y I Q G E S P V W R S Y V L L L S T L N S C V D P L V Y Y F S S S G F Q A D F H E L L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J21	A	Lipid	Free Fatty Acid	FFA3	Homo sapiens	Butyric acid	-	Gi1/β1/γ2	3.3	2024-01-24	10.1038/s41422-023-00914-z
	8J21 (No Gprot)	A	Lipid	Free Fatty Acid	FFA3	Homo sapiens	Butyric acid	-		3.3	2024-01-24	10.1038/s41422-023-00914-z
	8J20	A	Lipid	Free Fatty Acid	FFA3	Homo sapiens	Valeric acid	AR420626	Gi1/β1/γ2	3.2	2024-01-24	10.1038/s41422-023-00914-z
	8J20 (No Gprot)	A	Lipid	Free Fatty Acid	FFA3	Homo sapiens	Valeric acid	AR420626		3.2	2024-01-24	10.1038/s41422-023-00914-z

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