psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F18	R:R:H14	23.76	No	Yes	0	6	5
2	R:R:L16	R:R:W15	5.69	No	No	0	6	2
3	R:R:S259	R:R:V17	3.23	No	No	0	4	6
4	R:R:S19	R:R:V20	3.23	No	No	0	3	4
5	R:R:L263	R:R:V20	4.47	No	No	0	5	4
6	R:R:R71	R:R:Y21	4.12	No	No	0	6	7
7	R:R:T266	R:R:Y21	4.99	Yes	No	0	7	7
8	R:R:F23	R:R:L22	4.87	No	No	0	4	4
9	R:R:C270	R:R:T24	5.07	No	No	0	7	7
10	R:R:F25	R:R:L29	8.53	No	No	0	7	6
11	R:R:F25	R:R:P69	14.45	No	No	0	7	9
12	R:R:F25	R:R:M72	6.22	No	No	0	7	7
13	R:R:G28	R:R:V27	3.68	No	No	0	8	5
14	R:R:L29	R:R:L65	4.15	No	Yes	0	6	5
15	R:R:L31	R:R:P273	8.21	No	No	0	7	9
16	R:R:N32	R:R:T58	4.39	No	No	0	9	9
17	R:R:D61	R:R:N32	6.73	No	No	0	9	9
18	R:R:L62	R:R:N32	6.87	No	No	0	7	9
19	R:R:L33	R:R:L62	2.77	No	No	0	3	7
20	R:R:F287	R:R:L34	3.65	No	No	0	6	5
21	R:R:L36	R:R:T58	2.95	No	No	0	7	9
22	R:R:L36	R:R:L62	9.69	No	No	0	7	7
23	R:R:F283	R:R:I38	7.54	No	Yes	0	8	7
24	R:R:D286	R:R:I38	7	No	Yes	5	5	7
25	R:R:F287	R:R:I38	5.02	No	Yes	0	6	7
26	R:R:I38	R:R:L290	2.85	Yes	No	5	7	5
27	R:R:F39	R:R:L54	7.31	No	Yes	0	7	8
28	R:R:F283	R:R:F39	4.29	No	No	0	8	7
29	R:R:G41	R:R:R44	3	No	No	0	4	6
30	R:R:K42	R:R:R45	6.19	No	No	7	5	6
31	R:R:K42	R:R:R46	4.95	No	No	7	5	4
32	R:R:D51	R:R:K42	11.06	No	No	0	7	5
33	R:R:L43	R:R:L55	2.77	No	No	0	5	6
34	R:R:R45	R:R:R46	6.4	No	No	7	6	4
35	R:R:R46	R:R:V48	3.92	No	No	0	4	7
36	R:R:L129	R:R:P47	4.93	No	No	0	3	5
37	R:R:V48	R:R:V50	3.21	No	Yes	0	7	8
38	R:R:D51	R:R:V48	10.22	No	No	0	7	7
39	R:R:A49	R:R:E112	6.03	No	Yes	0	6	8
40	R:R:L54	R:R:V50	2.98	Yes	Yes	6	8	8
41	R:R:V109	R:R:V50	3.21	No	Yes	6	8	8
42	R:R:E112	R:R:V50	2.85	Yes	Yes	0	8	8
43	R:R:L53	R:R:V52	2.98	Yes	No	0	8	7
44	R:R:L53	R:R:V109	4.47	Yes	No	0	8	8
45	R:R:E112	R:R:L53	9.28	Yes	Yes	0	8	8
46	R:R:L53	R:R:S136	3	Yes	No	0	8	6
47	R:R:L54	R:R:V109	2.98	Yes	No	6	8	8
48	R:R:L54	R:R:Y276	11.72	Yes	No	0	8	9
49	R:R:L59	R:R:N56	6.87	No	Yes	3	5	9
50	R:R:F105	R:R:N56	4.83	Yes	Yes	3	7	9
51	R:R:N56	R:R:S136	4.47	Yes	No	0	9	6
52	R:R:N56	R:R:W140	9.04	Yes	Yes	3	9	9
53	R:R:L57	R:R:T102	4.42	No	No	0	9	9
54	R:R:F105	R:R:L57	7.31	Yes	No	0	7	9
55	R:R:L59	R:R:W140	3.42	No	Yes	3	5	9
56	R:R:L101	R:R:S60	3	Yes	No	0	7	8
57	R:R:D61	R:R:S269	8.83	No	No	0	9	8
58	R:R:D272	R:R:D61	5.32	No	No	0	9	9
59	R:R:L63	R:R:L94	4.15	No	Yes	0	7	5
60	R:R:L63	R:R:T98	4.42	No	No	0	7	9
61	R:R:L64	R:R:L65	4.15	Yes	Yes	4	6	5
62	R:R:L64	R:R:L68	2.77	Yes	Yes	4	6	7
63	R:R:L64	R:R:T98	10.32	Yes	No	0	6	9
64	R:R:L64	R:R:S269	3	Yes	No	4	6	8
65	R:R:L65	R:R:L68	2.77	Yes	Yes	4	5	7
66	R:R:L65	R:R:S269	6.01	Yes	No	4	5	8
67	R:R:F67	R:R:L94	4.87	No	Yes	0	6	5
68	R:R:L68	R:R:P69	6.57	Yes	No	0	7	9
69	R:R:F95	R:R:L68	3.65	Yes	Yes	0	6	7
70	R:R:F70	R:R:W81	8.02	Yes	Yes	2	6	9
71	R:R:F70	R:R:L83	4.87	Yes	No	2	6	7
72	R:R:F70	R:R:L87	8.53	Yes	No	2	6	5
73	R:R:F70	R:R:S91	5.28	Yes	No	0	6	5
74	R:R:R71	R:R:W81	4	No	Yes	0	6	9
75	R:R:F95	R:R:R71	9.62	Yes	No	0	6	6
76	R:R:M72	R:R:V73	4.56	No	No	0	7	4
77	R:R:E74	R:R:P82	3.14	No	No	0	5	4
78	R:R:L171	R:R:M79	5.65	No	No	0	4	5
79	R:R:C88	R:R:W81	6.53	No	Yes	2	9	9
80	R:R:C169	R:R:W81	5.22	No	Yes	2	9	9
81	R:R:L83	R:R:P84	4.93	No	No	0	7	8
82	R:R:L83	R:R:L87	4.15	No	No	2	7	5
83	R:R:F85	R:R:G167	3.01	No	No	0	4	4
84	R:R:I86	R:R:L87	2.85	No	No	0	2	5
85	R:R:C169	R:R:C88	7.28	No	No	2	9	9
86	R:R:P89	R:R:Y151	2.78	No	No	0	7	5
87	R:R:L90	R:R:L94	5.54	No	Yes	0	4	5
88	R:R:G92	R:R:Y170	4.35	No	No	0	5	4
89	R:R:F93	R:R:L94	6.09	Yes	Yes	0	5	5
90	R:R:F93	R:R:T97	6.49	Yes	No	0	5	4
91	R:R:F93	R:R:Y151	11.35	Yes	No	0	5	5
92	R:R:F95	R:R:I99	6.28	Yes	No	0	6	7
93	R:R:F95	R:R:L262	3.65	Yes	No	0	6	5
94	R:R:C147	R:R:F96	2.79	No	Yes	0	6	5
95	R:R:F96	R:R:Y170	11.35	Yes	No	0	5	4
96	R:R:F96	R:R:Y241	3.09	Yes	Yes	1	5	6
97	L:L:?1	R:R:F96	27.92	Yes	Yes	1	0	5
98	R:R:C147	R:R:T97	6.76	No	No	0	6	4
99	R:R:F238	R:R:I99	3.77	Yes	No	0	8	7
100	R:R:I99	R:R:S265	4.64	No	No	0	7	7
101	R:R:C147	R:R:Y100	4.03	No	Yes	0	6	7
102	R:R:M188	R:R:Y100	3.59	Yes	Yes	1	6	7
103	R:R:L192	R:R:Y100	11.72	No	Yes	1	6	7
104	R:R:Y100	R:R:Y241	4.96	Yes	Yes	1	7	6
105	R:R:F105	R:R:L101	13.4	Yes	Yes	3	7	7
106	R:R:L101	R:R:W140	10.25	Yes	Yes	3	7	9
107	R:R:A143	R:R:L101	3.15	No	Yes	0	7	7
108	R:R:A103	R:R:F234	2.77	No	Yes	0	7	9
109	R:R:A103	R:R:F238	2.77	No	Yes	0	7	8
110	R:R:C139	R:R:L104	7.94	No	No	0	7	5
111	R:R:L104	R:R:L192	2.77	No	No	0	5	6
112	R:R:C139	R:R:F105	5.59	No	Yes	0	7	7
113	R:R:F105	R:R:W140	5.01	Yes	Yes	3	7	9
114	R:R:F234	R:R:L106	9.74	Yes	No	0	9	8
115	R:R:S110	R:R:T200	6.4	No	No	0	9	8
116	R:R:C203	R:R:S110	3.44	No	No	0	7	9
117	R:R:S110	R:R:Y204	6.36	No	Yes	0	9	8
118	R:R:I111	R:R:I199	2.94	No	No	0	6	6
119	R:R:C203	R:R:I111	4.91	No	No	0	7	6
120	R:R:E112	R:R:Y123	6.73	Yes	No	0	8	5
121	R:R:R113	R:R:Y204	6.17	No	Yes	0	9	8
122	R:R:A118	R:R:F114	4.16	No	No	0	7	8
123	R:R:C203	R:R:F114	6.98	No	No	0	7	8
124	R:R:F114	R:R:R206	11.76	No	No	0	8	5
125	R:R:L115	R:R:W122	12.53	No	Yes	0	5	5
126	R:R:S116	R:R:V117	3.23	No	Yes	0	7	8
127	R:R:S116	R:R:Y123	8.9	No	No	0	7	5
128	R:R:L207	R:R:V117	4.47	No	Yes	0	8	8
129	R:R:I210	R:R:V117	4.61	No	Yes	0	5	8
130	R:R:A118	R:R:Y119	8.01	No	No	0	7	6
131	R:R:W122	R:R:Y123	2.89	Yes	No	0	5	5
132	R:R:R126	R:R:W122	14.99	Yes	Yes	9	4	5
133	R:R:R128	R:R:W122	15.99	No	Yes	9	5	5
134	R:R:R126	R:R:T125	10.35	Yes	No	0	4	4
135	R:R:R126	R:R:R128	4.26	Yes	No	9	4	5
136	R:R:Q131	R:R:R128	25.7	No	No	0	3	5
137	R:R:G133	R:R:S136	3.71	No	No	0	4	6
138	R:R:H146	R:R:L142	9	No	No	0	4	4
139	R:R:E187	R:R:H146	3.69	No	No	0	3	4
140	R:R:H146	R:R:M188	6.57	No	Yes	0	4	6
141	L:L:?1	R:R:V150	11.95	Yes	No	0	0	4
142	R:R:V152	R:R:Y151	3.79	No	No	0	4	5
143	R:R:I153	R:R:I180	2.94	No	No	0	4	3
144	R:R:E154	R:R:F173	19.82	No	No	1	5	5
145	R:R:E154	R:R:Q177	14.02	No	Yes	1	5	3
146	R:R:F155	R:R:S156	15.85	No	No	0	4	4
147	R:R:D158	R:R:S156	2.94	No	No	0	1	4
148	R:R:G157	R:R:R174	6	No	No	1	1	5
149	R:R:D176	R:R:G157	5.03	No	No	1	2	1
150	R:R:G167	R:R:N166	3.39	No	No	0	4	1
151	R:R:L171	R:R:T168	7.37	No	No	0	4	4
152	R:R:F173	R:R:Q177	3.51	No	Yes	1	5	3
153	R:R:D176	R:R:R174	3.57	No	No	1	2	5
154	R:R:D176	R:R:Q177	10.44	No	Yes	1	2	3
155	R:R:L181	R:R:L182	2.77	Yes	No	1	4	2
156	R:R:L181	R:R:R185	12.15	Yes	Yes	1	4	5
157	R:R:L182	R:R:Y249	9.38	No	No	0	2	5
158	R:R:P183	R:R:Y249	2.78	No	No	0	3	5
159	R:R:H245	R:R:R185	14.67	Yes	Yes	1	5	5
160	R:R:P255	R:R:R185	2.88	Yes	Yes	1	4	5
161	R:R:R185	R:R:R258	8.53	Yes	No	1	5	4
162	L:L:?1	R:R:R185	12.53	Yes	Yes	1	0	5
163	R:R:L186	R:R:Y249	19.93	No	No	0	4	5
164	R:R:E187	R:R:V191	11.41	No	No	0	3	4
165	R:R:L192	R:R:M188	4.24	No	Yes	1	6	6
166	L:L:?1	R:R:M188	4.86	Yes	Yes	1	0	6
167	R:R:A189	R:R:H245	4.39	No	Yes	0	5	5
168	R:R:V190	R:R:V191	3.21	No	No	0	4	4
169	R:R:F193	R:R:G194	3.01	No	No	0	8	4
170	R:R:F193	R:R:F234	7.5	No	Yes	0	8	9
171	R:R:F193	R:R:N242	30.21	No	No	0	8	8
172	R:R:P196	R:R:V195	3.53	No	No	0	9	5
173	R:R:F234	R:R:L197	9.74	Yes	No	0	9	6
174	R:R:L197	R:R:L235	2.77	No	No	0	6	5
175	R:R:R206	R:R:Y202	16.46	No	No	0	5	4
176	R:R:L207	R:R:Y204	8.21	No	Yes	0	8	8
177	R:R:V227	R:R:Y204	7.57	No	Yes	0	7	8
178	R:R:T230	R:R:Y204	3.75	No	Yes	0	7	8
179	R:R:R213	R:R:W209	3	No	No	0	4	3
180	R:R:I210	R:R:R213	10.02	No	No	0	5	4
181	R:R:L211	R:R:R219	3.64	No	No	0	8	5
182	R:R:L211	R:R:V223	4.47	No	No	0	8	8
183	R:R:G212	R:R:R220	6	No	No	0	4	7
184	R:R:A215	R:R:R219	2.77	No	No	0	3	5
185	R:R:L226	R:R:R222	3.64	No	No	0	7	7
186	R:R:R222	R:R:S281	5.27	No	No	0	7	4
187	R:R:F278	R:R:L226	3.65	No	No	0	7	7
188	R:R:L226	R:R:S279	4.5	No	No	0	7	6
189	R:R:N233	R:R:V271	11.82	No	No	0	6	7
190	R:R:N233	R:R:V275	4.43	No	No	0	6	7
191	R:R:C237	R:R:F238	2.79	No	Yes	8	8	8
192	R:R:C237	R:R:N268	9.45	No	No	8	8	9
193	R:R:F238	R:R:N268	4.83	Yes	No	8	8	9
194	R:R:G239	R:R:P240	4.06	No	No	0	5	9
195	R:R:P240	R:R:V261	3.53	No	No	0	9	6
196	R:R:L264	R:R:P240	3.28	No	No	0	7	9
197	R:R:N242	R:R:Y241	3.49	No	Yes	0	8	6
198	R:R:H245	R:R:Y241	10.89	Yes	Yes	1	5	6
199	R:R:V261	R:R:Y241	3.79	No	Yes	0	6	6
200	R:R:L262	R:R:Y241	4.69	No	Yes	0	5	6
201	L:L:?1	R:R:Y241	8.06	Yes	Yes	1	0	6
202	R:R:P255	R:R:S244	5.34	Yes	No	1	4	4
203	R:R:S244	R:R:W257	3.71	No	No	1	4	4
204	L:L:?1	R:R:H245	8.84	Yes	Yes	1	0	5
205	R:R:Q251	R:R:V247	4.3	No	No	0	1	5
206	R:R:E253	R:R:Q251	11.47	No	No	10	1	1
207	R:R:P255	R:R:S254	3.56	Yes	No	0	4	6
208	R:R:P255	R:R:W257	8.11	Yes	No	1	4	4
209	L:L:?1	R:R:R258	13.92	Yes	No	1	0	4
210	R:R:V261	R:R:Y260	5.05	No	No	0	6	4
211	R:R:L263	R:R:T266	4.42	No	Yes	0	5	7
212	R:R:L264	R:R:L267	4.15	No	No	0	7	5
213	R:R:L267	R:R:T266	2.95	No	Yes	0	5	7
214	R:R:D272	R:R:N268	12.12	No	No	0	9	9
215	R:R:F278	R:R:V275	5.24	No	No	0	7	7
216	R:R:F287	R:R:Y277	8.25	No	No	0	6	7
217	R:R:Q284	R:R:S281	2.89	No	No	0	8	4
218	R:R:D286	R:R:L290	4.07	No	No	5	5	5
219	R:R:H80	R:R:T168	2.74	No	No	0	4	4
220	R:R:D51	R:R:L43	2.71	No	No	0	7	5
221	R:R:P82	R:R:W81	2.7	No	Yes	0	4	9
222	R:R:F93	R:R:S148	2.64	Yes	No	0	5	4
223	R:R:R174	R:R:S156	2.64	No	No	0	5	4
224	R:R:R206	R:R:S205	2.64	No	No	0	5	3
225	R:R:R218	R:R:S216	2.64	No	No	0	4	3
226	R:R:F283	R:R:S280	2.64	No	No	0	8	8
227	R:R:D286	R:R:E289	2.6	No	No	0	5	4
228	R:R:V17	R:R:Y21	2.52	No	No	0	6	7
229	R:R:V256	R:R:W257	2.45	No	No	0	5	4
230	R:R:F18	R:R:L22	2.44	No	No	0	6	4
231	R:R:F173	R:R:L181	2.44	No	Yes	1	5	4
232	R:R:Q284	R:R:Y277	2.25	No	No	0	8	7
233	R:R:G194	R:R:P196	2.03	No	No	0	4	9
234	R:R:A132	R:R:G133	1.95	No	No	0	7	4
235	R:R:A228	R:R:G225	1.95	No	No	0	4	6
236	R:R:A285	R:R:G282	1.95	No	No	0	4	7
237	R:R:A107	R:R:P196	1.87	No	No	0	7	9
238	R:R:G282	R:R:S280	1.86	No	No	0	7	8
239	R:R:G41	R:R:V40	1.84	No	No	0	4	2
240	R:R:G248	R:R:V247	1.84	No	No	0	5	5
241	R:R:G78	R:R:M79	1.75	No	No	0	3	5
242	R:R:G28	R:R:L31	1.71	No	No	0	8	7
243	R:R:G28	R:R:L65	1.71	No	Yes	0	8	5
244	R:R:A75	R:R:S77	1.71	No	No	0	5	3
245	R:R:G130	R:R:L129	1.71	No	No	0	3	3
246	R:R:C139	R:R:V135	1.71	No	No	0	7	5
247	R:R:A76	R:R:V17	1.7	No	No	0	3	6
248	R:R:A108	R:R:V135	1.7	No	No	0	5	5
249	R:R:A189	R:R:V246	1.7	No	No	0	5	5
250	R:R:A224	R:R:V208	1.7	No	No	0	5	4
251	R:R:A229	R:R:V275	1.7	No	No	0	5	7
252	R:R:A35	R:R:T58	1.68	No	No	0	9	9
253	R:R:L29	R:R:P30	1.64	No	No	0	6	4
254	R:R:L43	R:R:P47	1.64	No	No	0	5	5
255	R:R:G130	R:R:Q131	1.64	No	No	0	3	3
256	R:R:G252	R:R:Q251	1.64	No	No	10	3	1
257	R:R:E253	R:R:G252	1.64	No	No	10	1	3
258	R:R:A76	R:R:M79	1.61	No	No	0	3	5
259	R:R:V208	R:R:V223	1.6	No	No	0	4	8
260	R:R:T24	R:R:T266	1.57	No	Yes	0	7	7
261	R:R:I153	R:R:V149	1.54	No	No	0	4	7
262	R:R:L141	R:R:S144	1.5	No	No	0	4	3
263	R:R:G248	R:R:R185	1.5	No	Yes	0	5	5
264	R:R:L231	R:R:S201	1.5	No	No	0	7	4
265	R:R:L26	R:R:V27	1.49	No	No	0	4	5
266	R:R:L211	R:R:V117	1.49	No	Yes	0	8	8
267	R:R:L134	R:R:V137	1.49	No	No	0	3	4
268	R:R:L207	R:R:V223	1.49	No	No	0	8	8
269	R:R:L231	R:R:V227	1.49	No	No	0	7	7
270	R:R:L232	R:R:V236	1.49	No	No	0	4	5
271	R:R:L264	R:R:V236	1.49	No	No	0	7	5
272	R:R:A75	R:R:H14	1.46	No	Yes	0	5	5
273	R:R:A76	R:R:H14	1.46	No	Yes	0	3	5
274	R:R:P127	R:R:R126	1.44	No	Yes	0	7	4
275	R:R:P120	R:R:Y119	1.39	No	No	0	8	6
276	R:R:L274	R:R:L31	1.38	No	No	0	6	7
277	R:R:L291	R:R:L34	1.38	No	No	0	6	5
278	R:R:L178	R:R:L181	1.38	No	Yes	1	3	4
279	R:R:L178	R:R:L182	1.38	No	No	1	3	2
280	R:R:A224	R:R:R221	1.38	No	No	0	5	5
281	R:R:I153	R:R:Q177	1.37	No	Yes	0	4	3
282	R:R:F93	R:R:S144	1.32	Yes	No	0	5	3
283	R:R:R219	R:R:S216	1.32	No	No	0	5	3
284	R:R:H14	R:R:N13	1.28	Yes	No	0	5	4
285	R:R:F18	R:R:W15	1	No	No	0	6	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H14	6.99	4	0	5
2	R:R:I38	5.6025	4	5	7
3	R:R:V50	3.0625	4	6	8
4	R:R:L53	4.9325	4	0	8
5	R:R:L54	6.2475	4	6	8
6	R:R:N56	6.3025	4	3	9
7	R:R:L64	5.06	4	4	6
8	R:R:L65	3.758	5	4	5
9	R:R:L68	3.94	4	4	7
10	R:R:F70	6.675	4	2	6
11	R:R:W81	5.294	5	2	9
12	R:R:F93	5.578	5	0	5
13	R:R:L94	5.1625	4	0	5
14	R:R:F95	5.8	4	0	6
15	R:R:F96	11.2875	4	1	5
16	R:R:Y100	6.075	4	1	7
17	R:R:L101	7.45	4	3	7
18	R:R:F105	7.228	5	3	7
19	R:R:E112	6.2225	4	0	8
20	R:R:V117	3.45	4	0	8
21	R:R:W122	11.6	4	9	5
22	R:R:R126	7.76	4	9	4
23	R:R:W140	6.93	4	3	9
24	R:R:Q177	7.335	4	1	3
25	R:R:L181	4.685	4	1	4
26	R:R:R185	8.71	6	1	5
27	R:R:M188	4.815	4	1	6
28	R:R:Y204	6.412	5	0	8
29	R:R:F234	7.4375	4	0	9
30	R:R:F238	3.54	4	8	8
31	R:R:Y241	5.56714	7	1	6
32	R:R:H245	9.6975	4	1	5
33	R:R:P255	4.9725	4	1	4
34	R:R:T266	3.4825	4	0	7
35	L:L:?1	12.5829	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A76	R:R:H14	14.4383	1.46	No	Yes	0	3	5
2	R:R:A76	R:R:V17	23.4243	1.7	No	No	0	3	6
3	R:R:V17	R:R:Y21	26.2036	2.52	No	No	0	6	7
4	R:R:T266	R:R:Y21	11.3603	4.99	Yes	No	0	7	7
5	R:R:R71	R:R:Y21	36.3287	4.12	No	No	0	6	7
6	R:R:F95	R:R:R71	51.5922	9.62	Yes	No	0	6	6
7	R:R:F95	R:R:L68	46.7423	3.65	Yes	Yes	0	6	7
8	R:R:L65	R:R:L68	23.6319	2.77	Yes	Yes	4	5	7
9	R:R:L64	R:R:L68	16.9848	2.77	Yes	Yes	4	6	7
10	R:R:L64	R:R:S269	12.4082	3	Yes	No	4	6	8
11	R:R:D61	R:R:S269	22.0017	8.83	No	No	0	9	8
12	R:R:D61	R:R:N32	19.4856	6.73	No	No	0	9	9
13	R:R:L65	R:R:S269	12.2361	6.01	Yes	No	4	5	8
14	R:R:F95	R:R:L262	84.7365	3.65	Yes	No	0	6	5
15	R:R:L262	R:R:Y241	85.5516	4.69	No	Yes	0	5	6
16	R:R:Y100	R:R:Y241	72.4194	4.96	Yes	Yes	1	7	6
17	R:R:L192	R:R:Y100	74.9608	11.72	No	Yes	1	6	7
18	R:R:L104	R:R:L192	100	2.77	No	No	0	5	6
19	R:R:C139	R:R:L104	99.7064	7.94	No	No	0	7	5
20	R:R:C139	R:R:F105	98.7647	5.59	No	Yes	0	7	7
21	R:R:F105	R:R:N56	94.74	4.83	Yes	Yes	3	7	9
22	R:R:N56	R:R:S136	96.0006	4.47	Yes	No	0	9	6
23	R:R:L53	R:R:S136	94.6337	3	Yes	No	0	8	6
24	R:R:L53	R:R:V109	35.9692	4.47	Yes	No	0	8	8
25	R:R:L54	R:R:V109	24.2647	2.98	Yes	No	6	8	8
26	R:R:F39	R:R:L54	29.2411	7.31	No	Yes	0	7	8
27	R:R:F283	R:R:F39	28.2033	4.29	No	No	0	8	7
28	R:R:F283	R:R:I38	23.485	7.54	No	Yes	0	8	7
29	R:R:F287	R:R:I38	18.6048	5.02	No	Yes	0	6	7
30	R:R:V109	R:R:V50	10.8743	3.21	No	Yes	6	8	8
31	R:R:V48	R:R:V50	22.5637	3.21	No	Yes	0	7	8
32	R:R:E112	R:R:L53	58.1178	9.28	Yes	Yes	0	8	8
33	R:R:E112	R:R:V50	18.6453	2.85	Yes	Yes	0	8	8
34	R:R:D51	R:R:V48	13.2942	10.22	No	No	0	7	7
35	R:R:E112	R:R:Y123	53.8247	6.73	Yes	No	0	8	5
36	R:R:W122	R:R:Y123	11.9729	2.89	Yes	No	0	5	5
37	R:R:R71	R:R:W81	17.5366	4	No	Yes	0	6	9
38	R:R:C147	R:R:T97	16.9038	6.76	No	No	0	6	4
39	R:R:F93	R:R:T97	15.5014	6.49	Yes	No	0	5	4
40	R:R:C147	R:R:Y100	14.0839	4.03	No	Yes	0	6	7
41	L:L:?1	R:R:Y241	20.0425	8.06	Yes	Yes	1	0	6
42	L:L:?1	R:R:M188	26.2391	4.86	Yes	Yes	1	0	6
43	R:R:S116	R:R:Y123	44.6008	8.9	No	No	0	7	5
44	R:R:S116	R:R:V117	43.5478	3.23	No	Yes	0	7	8
45	R:R:L207	R:R:V117	28.8766	4.47	No	Yes	0	8	8
46	R:R:L207	R:R:Y204	23.7331	8.21	No	Yes	0	8	8
47	R:R:S110	R:R:Y204	16.3975	6.36	No	Yes	0	9	8
48	R:R:C203	R:R:S110	13.765	3.44	No	No	0	7	9
49	R:R:H245	R:R:Y241	19.1515	10.89	Yes	Yes	1	5	6
50	R:R:H245	R:R:R185	15.7799	14.67	Yes	Yes	1	5	5
51	R:R:L181	R:R:R185	33.0431	12.15	Yes	Yes	1	4	5
52	R:R:F173	R:R:L181	22.2548	2.44	No	Yes	1	5	4
53	R:R:F173	R:R:Q177	18.7364	3.51	No	Yes	1	5	3
54	L:L:?1	R:R:R185	35.63	12.53	Yes	Yes	1	0	5
55	R:R:D176	R:R:Q177	11.3147	10.44	No	Yes	1	2	3
56	R:R:N242	R:R:Y241	14.8534	3.49	No	Yes	0	8	6
57	R:R:F193	R:R:N242	13.3802	30.21	No	No	0	8	8
58	R:R:L211	R:R:V117	11.3704	1.49	No	Yes	0	8	8
59	R:R:F287	R:R:Y277	14.737	8.25	No	No	0	6	7
60	R:R:Q284	R:R:Y277	13.4359	2.25	No	No	0	8	7
61	R:R:Q284	R:R:S281	12.1146	2.89	No	No	0	8	4
62	R:R:R222	R:R:S281	10.773	5.27	No	No	0	7	4
63	R:R:L264	R:R:P240	12.8284	3.28	No	No	0	7	9
64	R:R:V261	R:R:Y241	18.1947	3.79	No	Yes	0	6	6
65	R:R:P240	R:R:V261	15.3799	3.53	No	No	0	9	6
66	R:R:L192	R:R:M188	25.3177	4.24	No	Yes	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C147	R:R:F96	2.79	0	No	Yes	6	5	2	1
R:R:F96	R:R:Y170	11.35	1	Yes	No	5	4	1	2
R:R:F96	R:R:Y241	3.09	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:F96	27.92	1	Yes	Yes	0	5	0	1
R:R:C147	R:R:Y100	4.03	0	No	Yes	6	7	2	2
R:R:M188	R:R:Y100	3.59	1	Yes	Yes	6	7	1	2
R:R:L192	R:R:Y100	11.72	1	No	Yes	6	7	2	2
R:R:Y100	R:R:Y241	4.96	1	Yes	Yes	7	6	2	1
R:R:H146	R:R:M188	6.57	0	No	Yes	4	6	2	1
L:L:?1	R:R:V150	11.95	1	Yes	No	0	4	0	1
R:R:L181	R:R:R185	12.15	1	Yes	Yes	4	5	2	1
R:R:H245	R:R:R185	14.67	1	Yes	Yes	5	5	1	1
R:R:P255	R:R:R185	2.88	1	Yes	Yes	4	5	2	1
R:R:R185	R:R:R258	8.53	1	Yes	No	5	4	1	1
L:L:?1	R:R:R185	12.53	1	Yes	Yes	0	5	0	1
R:R:L192	R:R:M188	4.24	1	No	Yes	6	6	2	1
L:L:?1	R:R:M188	4.86	1	Yes	Yes	0	6	0	1
R:R:A189	R:R:H245	4.39	0	No	Yes	5	5	2	1
R:R:N242	R:R:Y241	3.49	0	No	Yes	8	6	2	1
R:R:H245	R:R:Y241	10.89	1	Yes	Yes	5	6	1	1
R:R:V261	R:R:Y241	3.79	0	No	Yes	6	6	2	1
R:R:L262	R:R:Y241	4.69	0	No	Yes	5	6	2	1
L:L:?1	R:R:Y241	8.06	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:H245	8.84	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R258	13.92	1	Yes	No	0	4	0	1
R:R:G248	R:R:R185	1.5	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8J21_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	257
Number of Links	285
Number of Hubs	35
Number of Links mediated by Hubs	126
Number of Communities	10
Number of Nodes involved in Communities	54
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	42268
Length Of Smallest Path	3
Average Path Length	14.3594
Length of Longest Path	34
Minimum Path Strength	1.37
Average Path Strength	5.74766
Maximum Path Strength	20.845
Minimum Path Correlation	0.7
Average Path Correlation	0.930086
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	48.5515
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.5809
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • lipid binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • multicellular organismal process • positive regulation of biological process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • biosynthetic process • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • immune response • immune system process • mucosal immune response • organ or tissue specific immune response • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • positive regulation of acute inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • response to stress • regulation of response to stress • regulation of acute inflammatory response to non-antigenic stimulus • acute inflammatory response • defense response • acute inflammatory response to non-antigenic stimulus • response to external stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response to non-antigenic stimulus • regulation of response to stimulus • positive regulation of defense response • regulation of acute inflammatory response • inflammatory response • regulation of localization • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • transport • hormone secretion • localization • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • peptide transport • peptide hormone secretion • regulation of cell communication • hormone transport • response to fatty acid • cellular response to fatty acid • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • catecholamine transport • norepinephrine transport • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • regulation of hormone biosynthetic process • regulation of hormone metabolic process • hormone metabolic process • hormone biosynthetic process • regulation of immune effector process • positive regulation of immune effector process • regulation of immune system process • cytokine production involved in immune response • positive regulation of immune system process • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune effector process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • system process • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • response to peptide hormone • regulation of signal transduction • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • cell surface receptor signaling pathway • regulation of insulin receptor signaling pathway • cellular response to peptide hormone stimulus • response to insulin • cellular response to insulin stimulus • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BUA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	BUA
Name	Butyric Acid
Synonyms	α-keto-γ-methylselenobutyrate
Identifier
Formula	C4 H8 O2
Molecular Weight	88.105
SMILES
PubChem	264
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	13
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O14843
Sequence	>8J21_nogp_Chain_R N H W L V F S V Y L F T F L V G L P L N L L A L V I F V G K L R R R P V A V D V L L L N L T L S D L L L L L F L P F R M V E A A S G M H W P L P F I L C P L S G F L F F T T I Y L T A L F L A A V S I E R F L S V A Y P L W Y K T R P R L G Q A G L V S V A C W L L A S A H C S V V Y V I E F S G D T N G T C Y L E F R E D Q L A I L L P V R L E M A V V L F G V P L L I T S Y C Y S R L V W I L G R G A S H R R R R R V A G L V A A T L L N F L V C F G P Y N V S H V V G Y I Q G E S P V W R S Y V L L L S T L N S C V D P L V Y Y F S S S G F Q A D F H E L L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J20	A	Lipid	Free Fatty Acid	FFA3	Homo sapiens	Valeric acid	AR420626	Gi1/β1/γ2	3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J20 (No Gprot)	A	Lipid	Free Fatty Acid	FFA3	Homo sapiens	Valeric acid	AR420626		3.2	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J21	A	Lipid	Free Fatty Acid	FFA3	Homo sapiens	Butyric acid	-	Gi1/β1/γ2	3.3	2024-01-24	doi.org/10.1038/s41422-023-00914-z
	8J21 (No Gprot)	A	Lipid	Free Fatty Acid	FFA3	Homo sapiens	Butyric acid	-		3.3	2024-01-24	doi.org/10.1038/s41422-023-00914-z

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.