Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P277 5.7925408
2R:R:Y288 9.14167696
3R:R:G297 2.1575408
4R:R:P302 5.7475405
5R:R:K304 6.0025124
6R:R:Y306 8.374123
7R:R:Y310 6.5425405
8R:R:F311 5.214547
9R:R:W322 5.674509
10R:R:Y341 8.855458
11R:R:D344 7.485459
12R:R:R347 7.415459
13R:R:F348 5.48559
14R:R:Y350 6.078559
15R:R:R353 4.46167659
16R:R:I356 7.09458
17R:R:F357 6.8575458
18R:R:Y369 3.7748
19R:R:F373 3.7925186
20R:R:V380 2.235407
21R:R:F385 10.015494
22R:R:Q395 8.32497
23R:R:F406 5.585689
24R:R:L409 5.04407
25R:R:Y410 5.84571789
26R:R:F411 4.445408
27R:R:M414 4.67489
28R:R:W419 6.79571759
29R:R:W420 8.0885109
30R:R:W427 5.325109
31R:R:L429 5.844199
32R:R:M433 5.72754196
33R:R:F447 4.51509
34R:R:W452 5.716559
35R:R:I462 6.185487
36R:R:V468 4.255488
37R:R:D471 6.02449
38R:R:L473 3.582547
39R:R:S474 5.006548
40R:R:F478 3.5575485
41R:R:V479 3.934589
42R:R:N483 6.69597
43R:R:Y498 3.504587
44R:R:I501 2.9775405
45R:R:L506 4.05254108
46R:R:R517 3.78754109
47R:R:L530 3.7409
48R:R:M534 2.9254109
49R:R:Y544 10.39409
50R:R:Y555 5.15404
51R:R:Y557 9.086549
52R:R:F561 10.6925445
53R:R:Q564 8.82443
54R:R:W565 11.26549
55R:R:C574 6.14254128
56R:R:Y577 5.196125
57R:R:I579 4.475406
58R:R:F603 5.2275447
59R:R:M604 3.5775408
60R:R:K606 6.33409
61R:R:Y607 4.64833649
62R:R:M609 4.855409
63R:R:V613 5.46409
64R:R:W620 9.785409
65R:R:W630 5.2625409
66A:A:N23 3.36437
67A:A:E27 5.0925436
68A:A:R30 3.57125835
69A:A:K33 6.1925435
70A:A:L46 3.07428
71A:A:K53 7.1725409
72A:A:G206 1.8725408
73A:A:I207 3.532519
74A:A:F212 6.7975409
75A:A:F219 7.2985218
76A:A:H220 9.3875417
77A:A:F222 7.72167617
78A:A:V224 6.56419
79A:A:Q227 4.39519
80A:A:R228 5.09419
81A:A:R232 3.955418
82A:A:K233 4.58143719
83A:A:C237 3.85518
84A:A:F238 6.78857719
85A:A:I245 3.45137
86A:A:F246 3.948529
87A:A:D249 5.8775408
88A:A:Y253 5.48333628
89A:A:L266 3.8175428
90A:A:Q267 4.1404
91A:A:L270 5.12406
92A:A:F273 5.086529
93A:A:W277 6.52714726
94A:A:W281 9.52515
95A:A:L282 4.1975409
96A:A:I288 5.6445139
97A:A:L289 4.428529
98A:A:F290 4.7385139
99A:A:L291 4.018528
100A:A:K293 7.7525409
101A:A:Q294 4.455426
102A:A:I308 8.9775427
103A:A:F312 4.498528
104A:A:F315 11.04426
105A:A:E330 5.3075403
106A:A:F340 5.49667627
107A:A:I341 3.112528
108A:A:R342 8.81424
109A:A:F345 7.678528
110A:A:L346 3.945424
111A:A:S349 3.62427
112A:A:C359 3.75425
113A:A:Y360 7.6265238
114A:A:F363 11.91425
115A:A:F376 7.8225218
116B:B:E10 9.875418
117B:B:L14 9.906518
118B:B:I18 8.792517
119B:B:R22 11.312516
120B:B:I33 4.0525403
121B:B:V40 3.0675473
122B:B:I43 5.1525403
123B:B:H54 8.108539
124B:B:K57 10.416519
125B:B:Y59 7.26518
126B:B:M61 4.99536
127B:B:W63 5.7325837
128B:B:S67 4.58435
129B:B:R68 8.12405
130B:B:L70 5.865435
131B:B:V71 5.31408
132B:B:Q75 7.7675419
133B:B:D76 6.908539
134B:B:K78 5.326538
135B:B:I80 9.2525438
136B:B:I81 4.7475407
137B:B:W82 9.89833639
138B:B:Y85 7.484534
139B:B:K89 6.89833639
140B:B:H91 4.06405
141B:B:I93 4.142507
142B:B:L95 3.89408
143B:B:W99 9.02167619
144B:B:M101 4.7825419
145B:B:Y105 5.134506
146B:B:Y111 4.37404
147B:B:L117 4.03167619
148B:B:Y124 5.4685256
149B:B:T128 2.4954153
150B:B:E130 6.054153
151B:B:H142 6.763336119
152B:B:Y145 4.12714718
153B:B:R150 4.885406
154B:B:F151 3.57167609
155B:B:L152 4.776563
156B:B:I157 4.014117
157B:B:T159 5.2665119
158B:B:D163 8.0745119
159B:B:L168 3.788566
160B:B:W169 9.312867118
161B:B:F180 8.226567
162B:B:H183 7.128569
163B:B:D186 5.2775419
164B:B:V187 4.102569
165B:B:M188 5.0175418
166B:B:F199 8.692569
167B:B:V200 4.235416
168B:B:C204 4.976517
169B:B:K209 5.49333666
170B:B:W211 9.066568
171B:B:Q220 8.77417
172B:B:F222 10.8075418
173B:B:H225 5.6025819
174B:B:S227 4.9416
175B:B:D228 4.59833619
176B:B:I229 5.165417
177B:B:I232 3.2425418
178B:B:F234 4.156505
179B:B:F235 4.68776
180B:B:F241 6.68616
181B:B:T243 5.27518
182B:B:S245 5.58419
183B:B:D246 3.575419
184B:B:D247 9.14519
185B:B:R251 6.54418
186B:B:L252 3.8407
187B:B:F253 8.188516
188B:B:D258 11.6025417
189B:B:M262 5.48254244
190B:B:Y264 5.683336245
191B:B:I269 2.34264
192B:B:F278 4.67677
193B:B:R283 5.34679
194B:B:Y289 5.72607
195B:B:C294 4.6925405
196B:B:L300 3.8775476
197B:B:K301 9.344575
198B:B:R304 6.984265
199B:B:H311 9.43754149
200B:B:R314 9.57518
201B:B:L318 2.9825406
202B:B:T321 4.596537
203B:B:M325 5.266535
204B:B:T329 6.06408
205B:B:W332 9.17571719
206B:B:D333 7.7785149
207B:B:F335 5.635404
208B:B:K337 6.87754146
209B:B:W339 9.735149
210B:B:N340 4.7375409
211G:G:E17 6.7375466
212G:G:Q18 8.135419
213G:G:E22 5.848519
214G:G:Y40 8.585476
215G:G:D48 5.79333679
216G:G:P49 3.5025407
217G:G:F61 4.54429738
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:P299 R:R:Y577 14.20834.17NoYes075
2R:R:M309 R:R:P299 19.85296.71NoNo067
3R:R:D471 R:R:L473 27.04044.07YesYes497
4R:R:F311 R:R:L473 14.21474.87YesYes477
5R:R:F311 R:R:Y310 11.72276.19YesYes075
6R:R:M309 R:R:Y310 22.177914.37NoYes065
7R:R:L473 R:R:V472 11.38342.98YesNo076
8R:R:V472 R:R:Y310 11.1952.52NoYes065
9R:R:D471 R:R:L481 30.1545.43YesNo097
10R:R:F478 R:R:L481 30.3413.65YesNo057
11R:R:F478 R:R:Y410 38.06413.09YesYes859
12R:R:M414 R:R:Y410 50.32457.18YesYes899
13R:R:M414 R:R:Y498 51.22712.39YesYes897
14R:R:V421 R:R:Y498 51.63243.79NoYes097
15R:R:I501 R:R:V421 51.80143.07YesNo059
16R:R:F505 R:R:I501 64.93583.77NoYes095
17R:R:F505 R:R:L425 65.09927.31NoNo096
18R:R:L425 R:R:L429 64.89562.77NoYes069
19R:R:I440 R:R:L429 66.18932.85NoYes099
20R:R:I440 R:R:W435 89.61423.52NoNo099
21R:R:G502 R:R:I501 13.22193.53NoYes095
22R:R:G502 R:R:S424 13.03323.71NoNo098
23R:R:I516 R:R:K434 91.1494.36NoNo099
24A:A:N387 R:R:K434 90.99594.2NoNo089
25A:A:E390 A:A:N387 90.53627.89NoNo048
26A:A:E390 R:R:W435 90.38279.81NoNo049
27R:R:F510 R:R:M534 10.21442.49NoYes1099
28A:A:L388 R:R:I516 91.2792.85NoNo2089
29A:A:F246 A:A:L46 27.75074.87YesYes298
30A:A:F246 A:A:L289 1003.65YesYes299
31A:A:F273 A:A:L289 46.08793.65YesYes299
32A:A:F273 A:A:W277 46.86184.01YesYes296
33A:A:H357 A:A:W277 92.370422.22NoYes076
34A:A:H357 A:A:R356 92.21812.26NoNo072
35A:A:K389 A:A:R356 91.9136.19NoNo052
36A:A:K389 A:A:V394 91.76043.04NoNo058
37A:A:L388 A:A:V394 91.60774.47NoNo088
38A:A:C359 A:A:L289 46.43714.76YesYes259
39A:A:C359 A:A:W277 45.93872.61YesYes256
40B:B:C317 B:B:M61 27.23234.86NoYes076
41B:B:C317 B:B:S316 27.56573.44NoNo079
42B:B:S316 B:B:W332 27.73784.94NoYes099
43B:B:W332 B:B:Y59 69.68598.68YesYes198
44A:A:C237 B:B:Y59 66.79945.38YesYes188
45A:A:C237 A:A:F238 67.1062.79YesYes189
46A:A:F238 A:A:V224 23.75492.62YesYes199
47A:A:V224 A:A:W234 54.524714.71YesNo099
48A:A:R231 A:A:W234 54.53734NoNo099
49A:A:L272 A:A:R231 54.554.86NoNo089
50A:A:F246 A:A:L272 54.57566.09YesNo098
51A:A:F238 A:A:V241 50.01133.93YesNo099
52A:A:I285 A:A:V241 50.06683.07NoNo079
53A:A:I244 A:A:I285 27.04865.89NoNo087
54A:A:I244 A:A:L46 27.05022.85NoYes088
55A:A:I285 A:A:L282 23.07412.85NoYes079
56A:A:I276 A:A:L282 23.07942.85NoYes089
57A:A:F246 A:A:I276 23.07872.51YesNo298
58B:B:D333 B:B:N313 10.07244.04YesNo097
59B:B:N313 B:B:W332 10.27865.65NoYes079
60A:A:Q227 B:B:N119 21.99295.28YesNo099
61A:A:Q227 A:A:V224 31.60814.3YesYes199
62A:A:Q227 B:B:Y145 20.02375.64YesYes198
63A:A:K233 B:B:Y145 21.43563.58YesYes198
64A:A:K233 B:B:D228 20.92494.15YesYes199
65A:A:W281 B:B:W332 15.22254.69YesYes159
66B:B:R314 B:B:W332 18.175114.99YesYes189
67A:A:W281 B:B:D290 14.20410.05YesNo156
68B:B:D290 B:B:R314 14.226615.48NoYes168
69B:B:D258 B:B:R22 10.871817.87YesYes176
70B:B:D258 B:B:F222 11.15122.39YesYes178
71B:B:F222 B:B:F253 12.672612.86YesYes186
72B:B:F253 B:B:H225 14.25833.39YesYes169
73B:B:S227 B:B:S245 11.09794.89YesYes169
74B:B:D228 B:B:S227 20.90692.94YesYes196
75B:B:W297 B:B:Y264 20.69189.65NoYes085
76B:B:W297 B:B:Y289 21.19586.75NoYes087
77B:B:D291 B:B:Y289 25.32354.6NoYes087
78B:B:C271 B:B:D291 27.63953.11NoNo058
79B:B:C271 B:B:D290 28.0343.11NoNo056
80B:B:T321 B:B:W63 11.35227.28YesYes377
81B:B:M61 B:B:W63 18.90596.98YesYes367
82B:B:C148 B:B:R150 12.19125.57NoYes066
83B:B:C148 B:B:T102 12.32913.38NoNo068
84B:B:H142 B:B:T159 15.47845.48YesYes1199
85B:B:D163 B:B:H142 20.47616.3YesYes1199
86B:B:D163 B:B:G144 20.84545.03YesNo098
87B:B:G144 B:B:N119 20.93963.39NoNo089
88R:R:R353 R:R:Y350 19.51975.14YesYes599
89R:R:I440 R:R:Y350 23.3123.63NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8J9N
Class F
SubFamily Protein
Type Frizzled
SubType FZD1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.5
Date 2024-01-17 
D.O.I. 10.1038/s41421-023-00627-y
Net Summary
Imin 2.26
Number of Linked Nodes 921
Number of Links 1176
Number of Hubs 217
Number of Links mediated by Hubs 767
Number of Communities 26
Number of Nodes involved in Communities 274
Number of Links involved in Communities 425
Path Summary
Number Of Nodes in MetaPath 90
Number Of Links MetaPath 89
Number of Shortest Paths 3128220
Length Of Smallest Path 3
Average Path Length 35.3856
Length of Longest Path 67
Minimum Path Strength 1.42
Average Path Strength 5.45975
Maximum Path Strength 18.665
Minimum Path Correlation 0.7
Average Path Correlation 0.993875
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 46.0123
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.6883
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9UP38
Sequence
>8J9N_Chain_R
SCPRALKVP SYLNYHFLG EKDCGAPCE PTKVYGLMY FGPEELRFS 
RTWIGIWSV LCCASTLFT VLTYLVDMR RFSYPERPI IFLSGCYTA 
VAVAYIAGF LLEDRVVCN DKFAEDGAR TVAQGTKKE GCTILFMML 
YFFSMASSI WWVILSLTW FLAAGMKWG HEAIEANSQ YFHLAAWAV 
PAIKTITIL ALGQVDGDV LSGVCFVGL NNVDALRGF VLAPLFVYL 
FIGTSFLLA GFVSLFRIR TIMKHDGTK TEKLEKLMV RIGVFSVLY 
TVPATIVIA CYFYEQAFR DQWERSWVA QSCKSYAIP CPHLQPHPP 
MSPDFTVFM IKYLMTLIV GITSGFWIW SGKTLNSWR KFYTR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8J9N_Chain_A
QRNEEKAQR EANKKIEQL RRDKRDARR ATHRLLLLG ADNSGKSTI 
VKQMRTSGI FETKFQVDK VNFHMFDVG GQRDERRKW IQCFNDVTA 
IIFVVDSSD YNRLQEALN LFKSIWNNR WLRTISVIL FLNKQDLLA 
EKVLAGKSK IEDYFPEFA RYTTPEDAT PEPGEDPRV TRAKYFIRD 
EFLRISTAS GDGRHYCYP HFTCAVDTE NARRIFNDC KDTILQLNL 
KEYNLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8J9N_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8J9N_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8J9OFProteinFrizzledFZD1Homo sapiens---3.42024-01-1710.1038/s41421-023-00627-y




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8J9N.zip



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