Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R30 3.42625835
2A:A:K33 6.1925435
3A:A:L46 3.07428
4A:A:K53 7.1725409
5A:A:I207 3.532519
6A:A:F212 5.936509
7A:A:F219 7.2985158
8A:A:H220 9.3875417
9A:A:F222 7.72167617
10A:A:V224 6.56419
11A:A:Q227 4.39519
12A:A:R228 5.09419
13A:A:R232 3.955418
14A:A:K233 4.58143719
15A:A:C237 3.85518
16A:A:F238 6.78857719
17A:A:I245 3.45127
18A:A:F246 3.948529
19A:A:D249 5.8775408
20A:A:Y253 5.48333628
21A:A:L266 3.8175428
22A:A:Q267 4.1404
23A:A:L270 5.12406
24A:A:F273 5.086529
25A:A:W277 6.52714726
26A:A:W281 9.52515
27A:A:L282 4.1975409
28A:A:I288 5.6445129
29A:A:L289 4.428529
30A:A:F290 4.7385129
31A:A:L291 4.018528
32A:A:K293 7.7525409
33A:A:Q294 4.455426
34A:A:I308 8.9775427
35A:A:F312 4.498528
36A:A:F315 11.04426
37A:A:E330 5.3075403
38A:A:F340 5.49667627
39A:A:I341 3.112528
40A:A:R342 8.81424
41A:A:F345 7.678528
42A:A:L346 3.945424
43A:A:S349 3.62427
44A:A:C359 3.75425
45A:A:Y360 7.6265178
46A:A:F363 11.91425
47A:A:F376 7.8225158
48B:B:L14 4.032508
49B:B:I18 4.166517
50B:B:R22 8.56167616
51B:B:I33 3.325403
52B:B:V40 3.0675463
53B:B:I43 5.1525403
54B:B:H54 8.108539
55B:B:K57 10.416519
56B:B:Y59 7.26518
57B:B:M61 4.99536
58B:B:W63 5.7325837
59B:B:S67 4.58435
60B:B:R68 8.12405
61B:B:L70 5.865435
62B:B:V71 5.31408
63B:B:Q75 7.7675419
64B:B:D76 6.908539
65B:B:K78 5.326538
66B:B:I80 9.2525438
67B:B:I81 4.7475407
68B:B:W82 9.89833639
69B:B:Y85 7.484534
70B:B:K89 6.388539
71B:B:H91 4.06405
72B:B:I93 4.142507
73B:B:L95 3.89408
74B:B:W99 9.02167619
75B:B:M101 4.7825419
76B:B:Y105 5.134506
77B:B:Y111 4.37404
78B:B:L117 4.03167619
79B:B:D118 4.4675419
80B:B:Y124 5.4685206
81B:B:H142 6.763336109
82B:B:Y145 4.12714718
83B:B:R150 4.885406
84B:B:F151 3.57167609
85B:B:L152 4.776573
86B:B:I157 4.014107
87B:B:T159 5.2665109
88B:B:D163 8.0745109
89B:B:L168 3.788576
90B:B:W169 9.312867108
91B:B:F180 8.226577
92B:B:H183 7.128579
93B:B:D186 5.2775419
94B:B:V187 4.102579
95B:B:M188 5.0175418
96B:B:F199 8.692579
97B:B:V200 4.235416
98B:B:C204 4.976517
99B:B:K209 6.052576
100B:B:W211 9.066578
101B:B:Q220 8.77417
102B:B:F222 10.8075418
103B:B:H225 5.6025819
104B:B:S227 4.9416
105B:B:D228 4.59833619
106B:B:I229 5.165417
107B:B:I232 3.2425418
108B:B:F234 4.156505
109B:B:F235 4.68766
110B:B:F241 6.68616
111B:B:T243 5.27518
112B:B:S245 5.58419
113B:B:D246 3.575419
114B:B:D247 9.14519
115B:B:R251 6.54418
116B:B:L252 3.8407
117B:B:F253 8.188516
118B:B:D258 11.6025417
119B:B:M262 5.48254194
120B:B:Y264 5.683336195
121B:B:I269 2.34214
122B:B:F278 4.67667
123B:B:R283 5.34669
124B:B:Y289 5.72607
125B:B:C294 4.6925405
126B:B:L300 3.8775466
127B:B:K301 9.344565
128B:B:R304 6.984215
129B:B:H311 9.43754139
130B:B:R314 9.57518
131B:B:L318 2.9825406
132B:B:T321 4.596537
133B:B:M325 5.266535
134B:B:T329 6.06408
135B:B:W332 9.17571719
136B:B:D333 7.7785139
137B:B:F335 5.635404
138B:B:K337 6.87754136
139B:B:W339 9.735139
140B:B:N340 4.7375409
141G:G:E22 7.5975409
142G:G:Y40 8.585466
143G:G:D48 5.79333669
144G:G:P49 3.5025407
145G:G:F61 4.54429738
146R:R:P277 5.7925409
147R:R:Y288 9.14167696
148R:R:G297 2.1575408
149R:R:P302 5.7475403
150R:R:K304 6.0025144
151R:R:Y306 8.374142
152R:R:M309 7.4025406
153R:R:Y310 6.5425405
154R:R:F311 5.214547
155R:R:W322 5.674508
156R:R:Y341 8.855459
157R:R:R347 7.415459
158R:R:F348 5.48559
159R:R:Y350 6.078559
160R:R:R353 4.46167659
161R:R:I356 7.09458
162R:R:F357 6.8575458
163R:R:Y369 3.7748
164R:R:F373 3.7925246
165R:R:V380 2.235407
166R:R:F385 10.015493
167R:R:Q395 8.32496
168R:R:F406 5.585689
169R:R:L409 5.04406
170R:R:Y410 5.84571789
171R:R:F411 4.445408
172R:R:M414 4.67489
173R:R:W419 6.79571759
174R:R:W420 8.0885119
175R:R:W427 5.325119
176R:R:L429 5.844259
177R:R:M433 5.72754256
178R:R:F447 4.51509
179R:R:W452 5.716559
180R:R:I462 6.185487
181R:R:V468 4.255489
182R:R:D471 6.02449
183R:R:L473 3.582548
184R:R:S474 5.006547
185R:R:F478 3.5575486
186R:R:V479 3.934589
187R:R:N483 6.69596
188R:R:Y498 3.504587
189R:R:I501 2.9775405
190R:R:L506 4.05254118
191R:R:R517 3.78754119
192R:R:L530 3.7409
193R:R:M534 2.9254119
194R:R:Y544 10.39409
195R:R:Y555 5.15404
196R:R:Y557 5.784549
197R:R:F561 11.7925444
198R:R:Q564 13.505443
199R:R:W565 11.66549
200R:R:C574 6.14254149
201R:R:Y577 5.196144
202R:R:I579 4.475405
203R:R:F603 5.2275446
204R:R:K606 6.33409
205R:R:Y607 4.64833648
206R:R:M609 4.855409
207R:R:V613 5.46408
208R:R:W620 9.785409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:M61 26.42714.86NoYes076
2B:B:C317 B:B:S316 26.77533.44NoNo079
3B:B:S316 B:B:W332 26.95484.94NoYes099
4B:B:W332 B:B:Y59 68.10218.68YesYes198
5A:A:C237 B:B:Y59 64.71975.38YesYes188
6A:A:C237 A:A:F238 65.88322.79YesYes189
7A:A:F238 A:A:V241 49.27123.93YesNo099
8A:A:I285 A:A:V241 49.32993.07NoNo079
9A:A:I244 A:A:I285 26.70275.89NoNo087
10A:A:I244 A:A:L46 26.70622.85NoYes088
11A:A:F238 A:A:V224 23.26142.62YesYes199
12A:A:V224 A:A:W234 55.021714.71YesNo099
13A:A:R231 A:A:W234 55.03474NoNo099
14A:A:L272 A:A:R231 55.04754.86NoNo089
15A:A:F246 A:A:L272 55.07376.09YesNo098
16A:A:F246 A:A:L46 27.43484.87YesYes298
17A:A:I285 A:A:L282 22.68632.85NoYes079
18A:A:I276 A:A:L282 22.6972.85NoYes089
19A:A:F246 A:A:I276 22.69592.51YesNo298
20A:A:Q227 B:B:Y145 22.70955.64YesYes198
21A:A:Q227 B:B:N119 19.55315.28YesNo099
22A:A:K233 B:B:Y145 25.06763.58YesYes198
23A:A:K233 B:B:D228 24.5634.15YesYes199
24A:A:W281 B:B:W332 14.32174.69YesYes159
25B:B:R314 B:B:W332 17.372814.99YesYes189
26A:A:F246 A:A:L289 1003.65YesYes299
27A:A:F273 A:A:L289 46.10143.65YesYes299
28A:A:F273 A:A:W277 46.89714.01YesYes296
29A:A:C359 A:A:L289 46.45744.76YesYes259
30A:A:C359 A:A:W277 45.94942.61YesYes256
31A:A:H357 A:A:W277 92.389422.22NoYes076
32A:A:W281 B:B:D290 13.280410.05YesNo156
33B:B:D290 B:B:R314 13.305615.48NoYes168
34A:A:H357 A:A:R356 92.23422.26NoNo072
35A:A:K389 A:A:R356 91.92356.19NoNo052
36A:A:K389 A:A:V394 91.7683.04NoNo058
37A:A:L388 A:A:V394 91.61244.47NoNo088
38A:A:L388 R:R:I516 91.27752.85NoNo1889
39R:R:I516 R:R:K434 91.14524.36NoNo099
40A:A:N387 R:R:K434 90.98924.2NoNo089
41A:A:E390 A:A:N387 90.52097.89NoNo048
42A:A:E390 R:R:W435 90.36469.81NoNo049
43R:R:I440 R:R:W435 89.58163.52NoNo099
44R:R:I440 R:R:Y350 22.69043.63NoYes099
45R:R:R353 R:R:Y350 18.79015.14YesYes599
46R:R:F510 R:R:M534 10.30142.49NoYes1189
47R:R:I440 R:R:L429 66.77292.85NoYes099
48R:R:L425 R:R:L429 65.45752.77NoYes069
49R:R:F505 R:R:L425 65.63617.31NoNo096
50R:R:F505 R:R:I501 65.46983.77NoYes095
51R:R:G502 R:R:I501 12.75153.53NoYes095
52R:R:G502 R:R:S424 12.55863.71NoNo098
53B:B:D228 B:B:S227 24.56542.94YesYes196
54B:B:S227 B:B:S245 13.77814.89YesYes169
55B:B:H225 B:B:S245 10.25376.97YesYes199
56B:B:F253 B:B:H225 12.80923.39YesYes169
57B:B:D247 B:B:S227 10.76248.83YesYes196
58B:B:D247 B:B:H225 10.26227.56YesYes199
59B:B:T321 B:B:W63 10.74927.28YesYes377
60B:B:C148 B:B:R150 10.11695.57NoYes066
61B:B:C148 B:B:T102 10.26083.38NoNo068
62B:B:G144 B:B:N119 19.05063.39NoNo089
63B:B:H142 B:B:T159 13.53035.48YesYes1099
64B:B:D163 B:B:H142 18.56566.3YesYes1099
65B:B:D163 B:B:G144 18.95195.03YesNo098
66B:B:F234 B:B:V200 10.3653.93YesYes056
67B:B:C271 B:B:D290 26.17513.11NoNo056
68B:B:C271 B:B:D291 25.76643.11NoNo058
69B:B:D291 B:B:Y289 23.38084.6NoYes087
70B:B:W297 B:B:Y289 19.18036.75NoYes087
71B:B:D333 B:B:N313 10.81684.04YesNo097
72R:R:I501 R:R:V421 52.80263.07YesNo059
73R:R:V421 R:R:Y498 52.63073.79NoYes097
74R:R:M414 R:R:Y498 52.1472.39YesYes897
75R:R:M414 R:R:Y410 51.23087.18YesYes899
76R:R:F478 R:R:Y410 39.5463.09YesYes869
77R:R:F478 R:R:L481 31.67983.65YesNo067
78R:R:D471 R:R:L481 31.49075.43YesNo097
79R:R:D471 R:R:L473 28.31794.07YesYes498
80R:R:F311 R:R:L473 14.84414.87YesYes478
81R:R:F311 R:R:Y310 12.1276.19YesYes075
82R:R:M309 R:R:Y310 22.754914.37YesYes065
83R:R:M309 R:R:P299 20.04876.71YesNo067
84R:R:L473 R:R:V472 11.96282.98YesNo085
85R:R:V472 R:R:Y310 11.77122.52NoYes055
86R:R:P299 R:R:Y577 14.36644.17NoYes074
87B:B:W297 B:B:Y264 18.64869.65NoYes085
88B:B:N313 B:B:W332 11.0285.65NoYes079
89B:B:M61 B:B:W63 18.59146.98YesYes367
90A:A:Q227 A:A:V224 32.36474.3YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8J9N
Class F
SubFamily Protein
Type Frizzled
SubType FZD1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.5
Date 2024-01-17
D.O.I. doi.org/10.1038/s41421-023-00627-y
Net Summary
Imin 2.26
Number of Linked Nodes 910
Number of Links 1158
Number of Hubs 208
Number of Links mediated by Hubs 740
Number of Communities 25
Number of Nodes involved in Communities 266
Number of Links involved in Communities 410
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 2977291
Length Of Smallest Path 3
Average Path Length 35.2401
Length of Longest Path 66
Minimum Path Strength 1.39
Average Path Strength 5.33416
Maximum Path Strength 18.665
Minimum Path Correlation 0.7
Average Path Correlation 0.992927
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 45.6821
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.6533
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8J9N_Chain_A
QRNEEKAQR EANKKIEQL RRDKRDARR ATHRLLLLG ADNSGKSTI 
VKQMRTSGI FETKFQVDK VNFHMFDVG GQRDERRKW IQCFNDVTA 
IIFVVDSSD YNRLQEALN LFKSIWNNR WLRTISVIL FLNKQDLLA 
EKVLAGKSK IEDYFPEFA RYTTPEDAT PEPGEDPRV TRAKYFIRD 
EFLRISTAS GDGRHYCYP HFTCAVDTE NARRIFNDC KDTILQLNL 
KEYNLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8J9N_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8J9N_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9UP38
Sequence
>8J9N_Chain_R
SCPRALKVP SYLNYHFLG EKDCGAPCE PTKVYGLMY FGPEELRFS 
RTWIGIWSV LCCASTLFT VLTYLVDMR RFSYPERPI IFLSGCYTA 
VAVAYIAGF LLEDRVVCN DKFAEDGAR TVAQGTKKE GCTILFMML 
YFFSMASSI WWVILSLTW FLAAGMKWG HEAIEANSQ YFHLAAWAV 
PAIKTITIL ALGQVDGDV LSGVCFVGL NNVDALRGF VLAPLFVYL 
FIGTSFLLA GFVSLFRIR TIMKHDGTK TEKLEKLMV RIGVFSVLY 
TVPATIVIA CYFYEQAFR DQWERSWVA QSCKSYAIP CPHLQPHPP 
MSPDFTVFM IKYLMTLIV GITSGFWIW SGKTLNSWR KFYTR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8J9N (No Gprot) FProteinFrizzledFZD1Homo sapiens--3.52024-01-17doi.org/10.1038/s41421-023-00627-y
8J9OFProteinFrizzledFZD1Homo sapiens---3.42024-01-17doi.org/10.1038/s41421-023-00627-y




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8J9N.zip



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