psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I579	R:R:S275	4.64	Yes	No	0	5	3
2	R:R:C276	R:R:P277	3.77	No	No	0	9	9
3	R:R:C276	R:R:K281	6.47	No	No	0	9	5
4	R:R:C276	R:R:C296	7.28	No	No	0	9	9
5	R:R:L280	R:R:P277	9.85	No	No	0	4	9
6	R:R:I579	R:R:P277	6.77	Yes	No	0	5	9
7	R:R:L280	R:R:P299	3.28	No	No	0	4	7
8	R:R:V282	R:R:Y288	13.88	No	Yes	0	5	6
9	R:R:P283	R:R:Y285	5.56	No	No	0	3	3
10	R:R:L286	R:R:P283	4.93	No	No	3	4	3
11	R:R:F385	R:R:P283	15.89	Yes	No	3	3	3
12	R:R:L286	R:R:Y288	11.72	No	Yes	3	4	6
13	R:R:F385	R:R:L286	4.87	Yes	No	3	3	4
14	R:R:K294	R:R:N287	8.39	No	No	0	1	4
15	R:R:N382	R:R:Y288	4.65	No	Yes	3	6	6
16	R:R:F385	R:R:Y288	7.22	Yes	Yes	3	3	6
17	R:R:Q395	R:R:Y288	9.02	Yes	Yes	3	6	6
18	R:R:K398	R:R:Y288	8.36	No	Yes	0	7	6
19	R:R:H289	R:R:K294	6.55	No	No	0	4	1
20	R:R:H289	R:R:Q395	11.13	No	Yes	0	4	6
21	R:R:F290	R:R:L291	6.09	No	No	0	6	4
22	R:R:F290	R:R:G297	3.01	No	Yes	0	6	8
23	R:R:A298	R:R:F290	4.16	No	No	0	5	6
24	R:R:M309	R:R:P299	6.71	Yes	No	0	6	7
25	R:R:P299	R:R:Y577	4.17	No	Yes	0	7	4
26	R:R:C300	R:R:C381	7.28	No	No	6	9	9
27	R:R:E301	R:R:P302	6.29	No	Yes	0	4	3
28	R:R:E301	R:R:T303	7.06	No	No	0	4	3
29	R:R:E301	R:R:R391	6.98	No	No	0	4	4
30	R:R:L308	R:R:P302	4.93	No	Yes	0	5	3
31	R:R:P302	R:R:P313	9.74	Yes	No	0	3	3
32	R:R:K304	R:R:Y306	3.58	Yes	Yes	4	4	2
33	R:R:G307	R:R:K304	5.23	No	Yes	0	8	4
34	R:R:C574	R:R:K304	4.85	Yes	Yes	4	9	4
35	R:R:K304	R:R:S576	9.18	Yes	No	4	4	1
36	R:R:K304	R:R:Y577	7.17	Yes	Yes	4	4	4
37	R:R:V305	R:R:Y306	10.09	No	Yes	0	3	2
38	R:R:Q572	R:R:Y306	15.78	No	Yes	4	4	2
39	R:R:C574	R:R:Y306	4.03	Yes	Yes	4	9	2
40	R:R:M309	R:R:Y310	14.37	Yes	No	0	6	5
41	R:R:M309	R:R:W569	5.82	Yes	No	0	6	5
42	R:R:F311	R:R:Y310	6.19	Yes	No	0	7	5
43	R:R:R562	R:R:Y310	3.09	No	No	0	7	5
44	R:R:E315	R:R:F311	3.5	No	Yes	1	7	7
45	R:R:F311	R:R:L473	4.87	Yes	Yes	1	7	8
46	R:R:F311	R:R:P598	7.22	Yes	No	0	7	9
47	R:R:F311	R:R:F603	4.29	Yes	No	1	7	6
48	R:R:G312	R:R:P313	4.06	No	No	7	5	3
49	R:R:E314	R:R:G312	3.27	No	No	7	4	5
50	R:R:E314	R:R:P313	4.72	No	No	7	4	3
51	R:R:E314	R:R:R317	3.49	No	No	0	4	4
52	R:R:E315	R:R:S319	5.75	No	No	1	7	7
53	R:R:E315	R:R:F600	17.49	No	No	1	7	6
54	R:R:D377	R:R:L316	4.07	No	No	0	6	5
55	R:R:R317	R:R:R320	7.46	No	No	0	4	5
56	R:R:F318	R:R:W322	10.02	No	Yes	0	7	8
57	R:R:F600	R:R:S319	3.96	No	No	1	6	7
58	R:R:F373	R:R:R320	4.28	Yes	No	0	6	5
59	R:R:E376	R:R:R320	15.12	No	No	0	6	5
60	R:R:F373	R:R:T321	3.89	Yes	No	0	6	4
61	R:R:I323	R:R:W322	3.52	No	Yes	0	7	8
62	R:R:W322	R:R:W326	5.62	Yes	No	0	8	7
63	R:R:M604	R:R:W322	4.65	No	Yes	0	7	8
64	R:R:L608	R:R:W322	4.56	No	Yes	0	7	8
65	R:R:I323	R:R:Y369	4.84	No	Yes	1	7	8
66	R:R:I323	R:R:Y607	6.04	No	Yes	1	7	8
67	R:R:F373	R:R:G324	6.02	Yes	No	0	6	5
68	R:R:I325	R:R:W326	4.7	No	No	0	4	7
69	R:R:I612	R:R:W326	3.52	No	No	0	7	7
70	R:R:I370	R:R:S327	6.19	No	No	0	5	8
71	R:R:I370	R:R:V328	3.07	No	No	0	5	4
72	R:R:A366	R:R:C330	3.61	No	No	0	8	9
73	R:R:C331	R:R:I370	3.27	No	No	0	6	5
74	R:R:I615	R:R:S333	3.1	No	No	0	8	9
75	R:R:T334	R:R:T363	9.42	No	No	0	8	5
76	R:R:L335	R:R:T363	2.95	No	No	0	5	5
77	R:R:S359	R:R:T337	7.99	No	No	0	8	9
78	R:R:I621	R:R:T337	4.56	No	No	0	7	9
79	R:R:L342	R:R:V338	2.98	No	No	0	7	7
80	R:R:I621	R:R:T340	4.56	No	No	0	7	9
81	R:R:T340	R:R:T626	3.14	No	No	0	9	9
82	R:R:M345	R:R:Y341	10.78	No	Yes	0	5	9
83	R:R:F348	R:R:Y341	7.22	Yes	Yes	2	9	9
84	R:R:R353	R:R:Y341	4.12	Yes	Yes	2	9	9
85	R:R:I356	R:R:Y341	13.3	Yes	Yes	2	8	9
86	R:R:D344	R:R:V343	4.38	No	No	0	9	7
87	R:R:F633	R:R:V343	17.04	No	No	0	6	7
88	R:R:D344	R:R:R347	8.34	No	Yes	2	9	9
89	R:R:D344	R:R:S629	10.31	No	No	2	9	8
90	R:R:F348	R:R:R347	9.62	Yes	Yes	2	9	9
91	R:R:R347	R:R:S629	9.22	Yes	No	2	9	8
92	R:R:F348	R:R:R353	4.28	Yes	Yes	2	9	9
93	R:R:F348	R:R:I356	3.77	Yes	Yes	2	9	8
94	R:R:P351	R:R:S349	5.34	No	No	0	9	5
95	R:R:R353	R:R:Y350	5.14	Yes	Yes	2	9	9
96	R:R:I440	R:R:Y350	3.63	No	Yes	0	9	9
97	R:R:E441	R:R:Y350	10.1	No	Yes	2	8	9
98	R:R:S444	R:R:Y350	6.36	No	Yes	2	8	9
99	R:R:F447	R:R:Y350	5.16	Yes	Yes	0	9	9
100	R:R:E352	R:R:W620	13.08	No	Yes	0	9	9
101	R:R:P354	R:R:R353	2.88	No	Yes	0	9	9
102	R:R:I356	R:R:R353	5.01	Yes	Yes	2	8	9
103	R:R:F357	R:R:R353	5.34	Yes	Yes	2	8	9
104	R:R:L423	R:R:P354	11.49	No	No	0	9	9
105	R:R:I355	R:R:L423	2.85	No	No	0	9	9
106	R:R:F540	R:R:I355	3.77	No	No	0	9	9
107	R:R:F357	R:R:I356	6.28	Yes	Yes	2	8	8
108	R:R:F357	R:R:W419	9.02	Yes	Yes	2	8	9
109	R:R:F357	R:R:H448	6.79	Yes	No	2	8	9
110	R:R:L358	R:R:Y362	4.69	No	No	0	8	9
111	R:R:G360	R:R:S359	3.71	No	No	0	6	8
112	R:R:G360	R:R:T363	3.64	No	No	0	6	5
113	R:R:S416	R:R:Y362	11.45	No	No	0	8	9
114	R:R:V613	R:R:Y362	8.83	Yes	No	0	8	9
115	R:R:A364	R:R:M408	3.22	No	No	0	5	5
116	R:R:A364	R:R:F412	9.71	No	No	0	5	9
117	R:R:A368	R:R:M408	4.83	No	No	0	7	5
118	R:R:A368	R:R:L409	3.15	No	Yes	0	7	6
119	R:R:L409	R:R:Y369	4.69	Yes	Yes	0	6	8
120	R:R:S474	R:R:Y369	3.82	Yes	Yes	1	7	8
121	R:R:Y369	R:R:Y607	3.97	Yes	Yes	1	8	8
122	R:R:L611	R:R:Y369	3.52	No	Yes	0	8	8
123	R:R:L375	R:R:V379	2.98	No	No	0	5	6
124	R:R:G470	R:R:V380	3.68	No	Yes	0	9	7
125	R:R:F385	R:R:N382	12.08	Yes	No	3	3	6
126	R:R:D388	R:R:E387	3.9	No	No	0	4	2
127	R:R:A394	R:R:K398	3.21	No	No	0	6	7
128	R:R:D469	R:R:Q395	6.53	No	Yes	3	8	6
129	R:R:N482	R:R:Q395	6.6	No	Yes	3	5	6
130	R:R:T397	R:R:T403	3.14	No	No	0	6	8
131	R:R:C402	R:R:C477	7.28	No	No	0	9	9
132	R:R:F406	R:R:Y410	5.16	Yes	Yes	5	9	9
133	R:R:F406	R:R:I462	6.28	Yes	Yes	5	9	7
134	R:R:F406	R:R:V468	10.49	Yes	Yes	0	9	9
135	R:R:F406	R:R:V479	6.55	Yes	No	5	9	9
136	R:R:L463	R:R:M407	7.07	No	No	0	8	8
137	R:R:L409	R:R:V476	7.45	Yes	No	0	6	7
138	R:R:F478	R:R:L409	4.87	No	Yes	0	6	6
139	R:R:M414	R:R:Y410	7.18	No	Yes	5	9	9
140	R:R:K458	R:R:Y410	11.94	No	Yes	5	7	9
141	R:R:T459	R:R:Y410	4.99	No	Yes	0	9	9
142	R:R:I462	R:R:Y410	6.04	Yes	Yes	5	7	9
143	R:R:F478	R:R:Y410	3.09	No	Yes	0	6	9
144	R:R:F411	R:R:F412	3.22	Yes	No	0	8	9
145	R:R:F411	R:R:W452	6.01	Yes	Yes	0	8	9
146	R:R:F411	R:R:P455	5.78	Yes	No	0	8	9
147	R:R:K458	R:R:M414	5.76	No	No	5	7	9
148	R:R:M414	R:R:P494	3.35	No	No	0	9	9
149	R:R:A415	R:R:W452	3.89	No	Yes	0	9	9
150	R:R:I418	R:R:Y498	6.04	No	No	0	6	7
151	R:R:I422	R:R:W419	5.87	No	Yes	0	6	9
152	R:R:H448	R:R:W419	7.41	No	Yes	2	9	9
153	R:R:A451	R:R:W419	7.78	No	Yes	2	9	9
154	R:R:W419	R:R:W452	12.18	Yes	Yes	2	9	9
155	R:R:S424	R:R:W420	7.41	No	No	0	8	9
156	R:R:W420	R:R:Y544	26.04	No	Yes	0	9	9
157	R:R:V421	R:R:Y498	3.79	No	No	0	9	7
158	R:R:I501	R:R:V421	3.07	Yes	No	0	5	9
159	R:R:F447	R:R:I422	5.02	Yes	No	0	9	6
160	R:R:G502	R:R:S424	3.71	No	No	0	9	8
161	R:R:L506	R:R:S424	6.01	No	No	0	8	8
162	R:R:F505	R:R:L425	7.31	No	No	0	9	6
163	R:R:F447	R:R:T426	3.89	Yes	No	0	9	9
164	R:R:A431	R:R:W427	3.89	No	Yes	0	9	9
165	R:R:L506	R:R:W427	3.42	No	Yes	0	8	9
166	R:R:G509	R:R:W427	4.22	No	Yes	0	9	9
167	R:R:F510	R:R:W427	8.02	No	Yes	8	8	9
168	R:R:I537	R:R:W427	7.05	Yes	Yes	8	9	9
169	R:R:F428	R:R:G432	3.01	No	No	0	8	8
170	R:R:F428	R:R:M433	3.73	No	No	0	8	6
171	R:R:L429	R:R:M433	11.31	No	No	0	9	6
172	R:R:H437	R:R:L429	6.43	No	No	0	7	9
173	R:R:I440	R:R:L429	2.85	No	No	0	9	9
174	R:R:G432	R:R:S512	3.71	No	No	0	8	8
175	R:R:G436	R:R:M433	5.24	No	No	0	7	6
176	R:R:I516	R:R:K434	4.36	No	No	0	9	9
177	R:R:I440	R:R:W435	3.52	No	No	0	9	9
178	R:R:E441	R:R:S444	4.31	No	No	2	8	8
179	R:R:N443	R:R:Y446	6.98	No	No	0	6	7
180	R:R:F447	R:R:N443	6.04	Yes	No	0	9	6
181	R:R:Q445	R:R:Y446	13.53	No	No	0	6	7
182	R:R:A451	R:R:W452	3.89	No	Yes	2	9	9
183	R:R:P455	R:R:V454	3.53	No	No	0	9	5
184	R:R:K458	R:R:T461	3	No	No	0	7	4
185	R:R:I462	R:R:V479	6.14	Yes	No	5	7	9
186	R:R:F490	R:R:I462	6.28	No	Yes	0	8	7
187	R:R:L463	R:R:V468	2.98	No	Yes	0	8	9
188	R:R:N483	R:R:Q467	10.56	Yes	No	3	6	6
189	R:R:D485	R:R:Q467	11.75	No	No	3	3	6
190	R:R:D469	R:R:N482	14.81	No	No	3	8	5
191	R:R:D469	R:R:N483	4.04	No	Yes	3	8	6
192	R:R:D471	R:R:L473	4.07	Yes	Yes	1	9	8
193	R:R:D471	R:R:S474	8.83	Yes	Yes	1	9	7
194	R:R:D471	R:R:L481	5.43	Yes	No	0	9	7
195	R:R:D471	R:R:Y607	5.75	Yes	Yes	1	9	8
196	R:R:L473	R:R:V472	2.98	Yes	No	0	8	5
197	R:R:F603	R:R:L473	3.65	No	Yes	1	6	8
198	R:R:G475	R:R:S474	3.71	No	Yes	0	9	7
199	R:R:S474	R:R:V476	4.85	Yes	No	0	7	7
200	R:R:S474	R:R:Y607	3.82	Yes	Yes	1	7	8
201	R:R:F478	R:R:L481	3.65	No	No	0	6	7
202	R:R:G480	R:R:N483	3.39	No	Yes	0	8	6
203	R:R:D485	R:R:N483	10.77	No	Yes	3	3	6
204	R:R:A486	R:R:N483	4.69	No	Yes	0	6	6
205	R:R:L487	R:R:Y555	3.52	No	Yes	0	8	4
206	R:R:Q559	R:R:R488	4.67	No	No	0	7	7
207	R:R:V491	R:R:Y555	7.57	No	Yes	0	8	4
208	R:R:I552	R:R:L495	5.71	No	No	0	7	8
209	R:R:F496	R:R:I552	8.79	No	No	0	4	7
210	R:R:L499	R:R:T503	2.95	No	No	0	8	6
211	R:R:G502	R:R:I501	3.53	No	Yes	0	9	5
212	R:R:F505	R:R:I501	3.77	No	Yes	0	9	5
213	R:R:L506	R:R:S541	4.5	No	No	0	8	8
214	R:R:F510	R:R:I537	5.02	No	Yes	8	8	9
215	R:R:R515	R:R:V511	3.92	No	No	0	8	7
216	R:R:L513	R:R:M534	4.24	No	No	0	8	9
217	R:R:F514	R:R:R517	3.21	No	No	0	7	9
218	R:R:L530	R:R:R517	3.64	No	No	0	9	9
219	R:R:E531	R:R:R517	5.82	No	No	0	9	9
220	R:R:I519	R:R:T518	3.04	No	No	0	6	6
221	R:R:M520	R:R:T525	3.01	No	No	0	8	5
222	R:R:M520	R:R:T527	6.02	No	No	0	8	8
223	R:R:L530	R:R:M520	4.24	No	No	0	9	8
224	R:R:K521	R:R:T527	3	No	No	0	8	8
225	R:R:K526	R:R:K529	2.87	No	No	0	8	9
226	R:R:R536	R:R:W620	13	No	Yes	0	9	9
227	R:R:I537	R:R:W620	7.05	Yes	Yes	0	9	9
228	R:R:F540	R:R:W620	6.01	No	Yes	0	9	9
229	R:R:L543	R:R:T616	11.79	No	No	0	8	8
230	R:R:A548	R:R:Y544	6.67	No	Yes	0	8	9
231	R:R:V613	R:R:Y544	6.31	Yes	Yes	0	8	9
232	R:R:P547	R:R:V546	3.53	No	No	0	9	7
233	R:R:M609	R:R:P547	5.03	Yes	No	0	9	9
234	R:R:P547	R:R:V613	3.53	No	Yes	0	9	8
235	R:R:I550	R:R:I605	2.94	No	No	0	4	7
236	R:R:I550	R:R:M609	4.37	No	Yes	0	4	9
237	R:R:C554	R:R:V602	3.42	No	No	0	8	6
238	R:R:C554	R:R:K606	9.7	No	No	0	8	9
239	R:R:K606	R:R:Y555	7.17	No	Yes	0	9	4
240	R:R:F556	R:R:Q559	5.86	No	No	0	4	7
241	R:R:E558	R:R:Y557	3.37	No	Yes	1	9	9
242	R:R:F561	R:R:Y557	7.22	Yes	Yes	1	4	9
243	R:R:W565	R:R:Y557	8.68	Yes	Yes	1	9	9
244	R:R:D599	R:R:Y557	4.6	No	Yes	1	5	9
245	R:R:V602	R:R:Y557	5.05	No	Yes	1	6	9
246	R:R:E558	R:R:W565	7.63	No	Yes	1	9	9
247	R:R:E558	R:R:F603	10.49	No	No	1	9	6
248	R:R:F561	R:R:Q564	24.6	Yes	Yes	1	4	3
249	R:R:F561	R:R:W565	11.02	Yes	Yes	1	4	9
250	R:R:F561	R:R:P595	4.33	Yes	No	1	4	1
251	R:R:Q564	R:R:W565	12.05	Yes	Yes	1	3	9
252	R:R:P594	R:R:Q564	4.74	No	Yes	0	1	3
253	R:R:P595	R:R:Q564	12.63	No	Yes	1	1	3
254	R:R:P598	R:R:W565	18.92	No	Yes	0	9	9
255	R:R:P594	R:R:S568	3.56	No	No	0	1	4
256	R:R:M596	R:R:S568	4.6	No	No	0	3	4
257	R:R:Q572	R:R:W569	3.29	No	No	0	4	5
258	R:R:C574	R:R:Q572	7.63	Yes	No	4	9	4
259	R:R:I579	R:R:S573	3.1	Yes	No	0	5	4
260	R:R:C581	R:R:S573	6.89	No	No	0	9	4
261	R:R:C574	R:R:Y577	8.06	Yes	Yes	4	9	4
262	R:R:S576	R:R:Y577	7.63	No	Yes	4	1	4
263	R:R:I579	R:R:P580	3.39	Yes	No	0	5	5
264	R:R:C581	R:R:H583	8.85	No	No	0	9	1
265	R:R:H583	R:R:L584	12.86	No	No	0	1	2
266	R:R:H593	R:R:P594	4.58	No	No	0	1	1
267	R:R:H593	R:R:M596	7.88	No	No	0	1	3
268	R:R:P598	R:R:S597	3.56	No	No	0	9	4
269	R:R:D599	R:R:T601	7.23	No	No	0	5	5
270	R:R:D599	R:R:V602	4.38	No	No	1	5	6
271	R:R:F600	R:R:M604	3.73	No	No	0	6	7
272	R:R:M604	R:R:T601	4.52	No	No	0	7	5
273	R:R:K606	R:R:Y607	5.97	No	Yes	0	9	8
274	R:R:L608	R:R:M609	5.65	No	Yes	0	7	9
275	R:R:I612	R:R:M609	4.37	No	Yes	0	7	9
276	R:R:T616	R:R:V613	3.17	No	Yes	0	8	8
277	R:R:G614	R:R:S617	3.71	No	No	0	9	9
278	R:R:F619	R:R:W622	14.03	No	No	0	6	6
279	R:R:G624	R:R:S623	3.71	No	No	0	5	9
280	R:R:K625	R:R:S623	3.06	No	No	0	9	9
281	R:R:T626	R:R:W630	3.64	No	No	0	9	9
282	R:R:N628	R:R:S629	2.98	No	No	0	4	8
283	R:R:W630	R:R:Y634	6.75	No	No	0	9	5
284	R:R:F633	R:R:R636	6.41	No	No	0	6	7
285	R:R:K399	R:R:N382	2.8	No	No	0	6	6
286	R:R:D383	R:R:K399	2.77	No	No	0	3	6
287	R:R:A456	R:R:F411	2.77	No	Yes	0	8	8
288	R:R:A508	R:R:F428	2.77	No	No	0	7	8
289	R:R:L513	R:R:L530	2.77	No	No	0	8	9
290	R:R:E566	R:R:M309	2.71	No	Yes	0	6	6
291	R:R:E528	R:R:K526	2.7	No	No	0	6	8
292	R:R:R488	R:R:V484	2.62	No	No	0	7	4
293	R:R:R567	R:R:V570	2.62	No	No	0	2	3
294	R:R:C361	R:R:W419	2.61	No	Yes	2	9	9
295	R:R:C361	R:R:W452	2.61	No	Yes	2	9	9
296	R:R:S327	R:R:Y369	2.54	No	Yes	0	8	8
297	R:R:S417	R:R:Y544	2.54	No	Yes	0	8	9
298	R:R:V365	R:R:Y369	2.52	No	Yes	0	8	8
299	R:R:F348	R:R:I621	2.51	Yes	No	0	9	7
300	R:R:F510	R:R:M534	2.49	No	No	0	8	9
301	R:R:K625	R:R:R347	2.48	No	Yes	0	9	9
302	R:R:F373	R:R:L374	2.44	Yes	No	0	6	3
303	R:R:T545	R:R:W420	2.43	No	No	0	8	9
304	R:R:L492	R:R:Y555	2.34	No	Yes	0	8	4
305	R:R:L627	R:R:W630	2.28	No	No	0	5	9
306	R:R:R378	R:R:R391	2.13	No	No	0	4	4
307	R:R:R631	R:R:Y634	2.06	No	No	0	5	5
308	R:R:G307	R:R:P302	2.03	No	Yes	0	8	3
309	R:R:C296	R:R:G297	1.96	No	Yes	0	9	8
310	R:R:C330	R:R:G614	1.96	No	No	0	9	9
311	R:R:C581	R:R:P582	1.88	No	No	0	9	4
312	R:R:A430	R:R:P351	1.87	No	No	0	8	9
313	R:R:A493	R:R:P494	1.87	No	No	0	5	9
314	R:R:G538	R:R:S541	1.86	No	No	0	9	8
315	R:R:G618	R:R:S617	1.86	No	No	0	8	9
316	R:R:G297	R:R:V282	1.84	Yes	No	0	8	5
317	R:R:G360	R:R:V338	1.84	No	No	0	6	7
318	R:R:G372	R:R:V476	1.84	No	No	0	9	7
319	R:R:G475	R:R:V380	1.84	No	Yes	0	9	7
320	R:R:G396	R:R:V468	1.84	No	Yes	0	6	9
321	R:R:G480	R:R:V479	1.84	No	No	0	8	9
322	R:R:G297	R:R:T392	1.82	Yes	No	0	8	5
323	R:R:G614	R:R:T334	1.82	No	No	0	9	8
324	R:R:G618	R:R:T337	1.82	No	No	0	8	9
325	R:R:P582	R:R:V570	1.77	No	No	0	4	3
326	R:R:G401	R:R:I404	1.76	No	No	0	4	5
327	R:R:P351	R:R:T426	1.75	No	No	0	9	9
328	R:R:G389	R:R:K384	1.74	No	No	0	4	4
329	R:R:C300	R:R:V393	1.71	No	No	6	9	7
330	R:R:C331	R:R:V367	1.71	No	No	0	6	4
331	R:R:C402	R:R:V379	1.71	No	No	0	9	6
332	R:R:C381	R:R:V380	1.71	No	Yes	0	9	7
333	R:R:C477	R:R:V380	1.71	No	Yes	0	9	7
334	R:R:C381	R:R:V393	1.71	No	No	6	9	7
335	R:R:C477	R:R:V468	1.71	No	Yes	0	9	9
336	R:R:D377	R:R:G475	1.68	No	No	0	6	9
337	R:R:S413	R:R:V365	1.62	No	No	0	6	8
338	R:R:T610	R:R:V551	1.59	No	No	0	6	7
339	R:R:A368	R:R:L405	1.58	No	No	0	7	7
340	R:R:A464	R:R:L465	1.58	No	No	0	7	5
341	R:R:A548	R:R:L499	1.58	No	No	0	8	8
342	R:R:C296	R:R:D295	1.56	No	No	0	9	5
343	R:R:I501	R:R:V497	1.54	Yes	No	0	5	5
344	R:R:I550	R:R:V551	1.54	No	No	0	4	7
345	R:R:A386	R:R:E387	1.51	No	No	0	1	2
346	R:R:M407	R:R:T403	1.51	No	No	0	8	8
347	R:R:A439	R:R:E441	1.51	No	No	0	9	8
348	R:R:F490	R:R:G489	1.51	No	No	0	8	4
349	R:R:K526	R:R:T525	1.5	No	No	0	8	5
350	R:R:L329	R:R:V328	1.49	No	No	0	6	4
351	R:R:L495	R:R:V551	1.49	No	No	0	8	7
352	R:R:A571	R:R:H583	1.46	No	No	0	3	1
353	R:R:I615	R:R:L329	1.43	No	No	0	8	6
354	R:R:I516	R:R:L513	1.43	No	No	0	9	8
355	R:R:I537	R:R:L533	1.43	Yes	No	0	9	9
356	R:R:G618	R:R:W622	1.41	No	No	0	8	6
357	R:R:L339	R:R:L342	1.38	No	No	0	6	7
358	R:R:E528	R:R:K532	1.35	No	No	0	6	8
359	R:R:A279	R:R:Y577	1.33	No	Yes	0	5	4
360	R:R:E293	R:R:L291	1.33	No	No	0	5	4
361	R:R:L465	R:R:Q467	1.33	No	No	0	5	6
362	R:R:L487	R:R:Q559	1.33	No	No	0	8	7
363	R:R:R515	R:R:T518	1.29	No	No	0	8	6
364	R:R:K281	R:R:R278	1.24	No	No	0	5	3
365	R:R:K384	R:R:R391	1.24	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y288	9.14167	6	3	6
2	R:R:G297	2.1575	4	0	8
3	R:R:P302	5.7475	4	0	3
4	R:R:K304	6.002	5	4	4
5	R:R:Y306	8.37	4	4	2
6	R:R:M309	7.4025	4	0	6
7	R:R:F311	5.214	5	1	7
8	R:R:W322	5.674	5	0	8
9	R:R:Y341	8.855	4	2	9
10	R:R:R347	7.415	4	2	9
11	R:R:F348	5.48	5	2	9
12	R:R:Y350	6.078	5	2	9
13	R:R:R353	4.46167	6	2	9
14	R:R:I356	7.09	4	2	8
15	R:R:F357	6.8575	4	2	8
16	R:R:Y369	3.7	7	1	8
17	R:R:F373	4.1575	4	0	6
18	R:R:V380	2.235	4	0	7
19	R:R:F385	10.015	4	3	3
20	R:R:Q395	8.32	4	3	6
21	R:R:F406	7.12	4	5	9
22	R:R:L409	5.04	4	0	6
23	R:R:Y410	6.4	6	5	9
24	R:R:F411	4.445	4	0	8
25	R:R:W419	7.47833	6	2	9
26	R:R:W427	5.32	5	8	9
27	R:R:F447	5.0275	4	0	9
28	R:R:W452	5.716	5	2	9
29	R:R:I462	6.185	4	5	7
30	R:R:V468	4.255	4	0	9
31	R:R:D471	6.02	4	1	9
32	R:R:L473	3.8925	4	1	8
33	R:R:S474	5.006	5	1	7
34	R:R:N483	6.69	5	3	6
35	R:R:I501	2.9775	4	0	5
36	R:R:I537	5.1375	4	8	9
37	R:R:Y544	10.39	4	0	9
38	R:R:Y555	5.15	4	0	4
39	R:R:Y557	5.784	5	1	9
40	R:R:F561	11.7925	4	1	4
41	R:R:Q564	13.505	4	1	3
42	R:R:W565	11.66	5	1	9
43	R:R:C574	6.1425	4	4	9
44	R:R:Y577	5.672	5	4	4
45	R:R:I579	4.475	4	0	5
46	R:R:Y607	5.11	5	1	8
47	R:R:M609	4.855	4	0	9
48	R:R:V613	5.46	4	0	8
49	R:R:W620	9.785	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C276	R:R:P277	10.4557	3.77	No	No	0	9	9
2	R:R:I579	R:R:P277	13.6254	6.77	Yes	No	0	5	9
3	R:R:L280	R:R:P277	23.503	9.85	No	No	0	4	9
4	R:R:L280	R:R:P299	24.5888	3.28	No	No	0	4	7
5	R:R:Q395	R:R:Y288	16.7497	9.02	Yes	Yes	3	6	6
6	R:R:M309	R:R:P299	50.1164	6.71	Yes	No	0	6	7
7	R:R:P299	R:R:Y577	29.0347	4.17	No	Yes	0	7	4
8	R:R:G475	R:R:V380	10.0495	1.84	No	Yes	0	9	7
9	R:R:G475	R:R:S474	12.3881	3.71	No	Yes	0	9	7
10	R:R:D471	R:R:S474	35.4459	8.83	Yes	Yes	1	9	7
11	R:R:D471	R:R:L473	72.8727	4.07	Yes	Yes	1	9	8
12	R:R:F311	R:R:L473	61.3578	4.87	Yes	Yes	1	7	8
13	R:R:F311	R:R:Y310	59.4426	6.19	Yes	No	0	7	5
14	R:R:M309	R:R:Y310	57.5008	14.37	Yes	No	0	6	5
15	R:R:G307	R:R:P302	21.7971	2.03	No	Yes	0	8	3
16	R:R:G307	R:R:K304	22.9828	5.23	No	Yes	0	8	4
17	R:R:K304	R:R:Y577	24.0779	7.17	Yes	Yes	4	4	4
18	R:R:P302	R:R:P313	12.2772	9.74	Yes	No	0	3	3
19	R:R:F311	R:R:P598	11.2915	7.22	Yes	No	0	7	9
20	R:R:M604	R:R:W322	11.2087	4.65	No	Yes	0	7	8
21	R:R:D471	R:R:Y607	20.149	5.75	Yes	Yes	1	9	8
22	R:R:L608	R:R:W322	24.9496	4.56	No	Yes	0	7	8
23	R:R:S474	R:R:Y369	22.5392	3.82	Yes	Yes	1	7	8
24	R:R:Y369	R:R:Y607	24.8059	3.97	Yes	Yes	1	8	8
25	R:R:G618	R:R:T337	13.9394	1.82	No	No	0	8	9
26	R:R:I621	R:R:T337	29.4909	4.56	No	No	0	7	9
27	R:R:F348	R:R:I621	41.1666	2.51	Yes	No	0	9	7
28	R:R:F348	R:R:R353	31.917	4.28	Yes	Yes	2	9	9
29	R:R:F357	R:R:R353	44.1114	5.34	Yes	Yes	2	8	9
30	R:R:F357	R:R:W419	73.8709	9.02	Yes	Yes	2	8	9
31	R:R:W419	R:R:W452	92.3312	12.18	Yes	Yes	2	9	9
32	R:R:F411	R:R:W452	94.9651	6.01	Yes	Yes	0	8	9
33	R:R:F411	R:R:F412	97.0959	3.22	Yes	No	0	8	9
34	R:R:A364	R:R:F412	97.638	9.71	No	No	0	5	9
35	R:R:A364	R:R:M408	98.1957	3.22	No	No	0	5	5
36	R:R:A368	R:R:M408	98.7596	4.83	No	No	0	7	5
37	R:R:A368	R:R:L409	100	3.15	No	Yes	0	7	6
38	R:R:L409	R:R:Y369	58.0788	4.69	Yes	Yes	0	6	8
39	R:R:F348	R:R:I356	27.1539	3.77	Yes	Yes	2	9	8
40	R:R:F357	R:R:I356	29.4081	6.28	Yes	Yes	2	8	8
41	R:R:L409	R:R:V476	19.2695	7.45	Yes	No	0	6	7
42	R:R:S474	R:R:V476	19.1945	4.85	Yes	No	0	7	7
43	R:R:F478	R:R:L409	46.3172	4.87	No	Yes	0	6	6
44	R:R:F478	R:R:L481	21.5769	3.65	No	No	0	6	7
45	R:R:D471	R:R:L481	21.5425	5.43	Yes	No	0	9	7
46	R:R:S359	R:R:T337	13.9409	7.99	No	No	0	8	9
47	R:R:G360	R:R:S359	12.2085	3.71	No	No	0	6	8
48	R:R:I621	R:R:T340	10.4073	4.56	No	No	0	7	9
49	R:R:F348	R:R:R347	17.1356	9.62	Yes	Yes	2	9	9
50	R:R:I422	R:R:W419	18.1135	5.87	No	Yes	0	6	9
51	R:R:F447	R:R:I422	17.2949	5.02	Yes	No	0	9	6
52	R:R:R353	R:R:Y350	14.5002	5.14	Yes	Yes	2	9	9
53	R:R:F447	R:R:Y350	12.3522	5.16	Yes	Yes	0	9	9
54	R:R:I440	R:R:Y350	17.4012	3.63	No	Yes	0	9	9
55	R:R:L506	R:R:W427	14.9079	3.42	No	Yes	0	8	9
56	R:R:L506	R:R:S424	15.7046	6.01	No	No	0	8	8
57	R:R:S424	R:R:W420	17.9542	7.41	No	No	0	8	9
58	R:R:W420	R:R:Y544	18.4353	26.04	No	Yes	0	9	9
59	R:R:V613	R:R:Y544	19.6304	6.31	Yes	Yes	0	8	9
60	R:R:P547	R:R:V613	21.0364	3.53	No	Yes	0	9	8
61	R:R:M609	R:R:P547	21.5238	5.03	Yes	No	0	9	9
62	R:R:L608	R:R:M609	24.4778	5.65	No	Yes	0	7	9
63	R:R:D469	R:R:Q395	19.91	6.53	No	Yes	3	8	6
64	R:R:D469	R:R:N483	21.7362	4.04	No	Yes	3	8	6
65	R:R:G480	R:R:N483	26.8914	3.39	No	Yes	0	8	6
66	R:R:G480	R:R:V479	27.8412	1.84	No	No	0	8	9
67	R:R:F406	R:R:V479	14.922	6.55	Yes	No	5	9	9
68	R:R:F478	R:R:Y410	36.1099	3.09	No	Yes	0	6	9
69	R:R:F406	R:R:Y410	18.1104	5.16	Yes	Yes	5	9	9
70	R:R:I462	R:R:Y410	15.275	6.04	Yes	Yes	5	7	9
71	R:R:I462	R:R:V479	13.9066	6.14	Yes	No	5	7	9
72	R:R:L429	R:R:M433	10.4776	11.31	No	No	0	9	6
73	R:R:I440	R:R:L429	13.9456	2.85	No	No	0	9	9
74	R:R:K606	R:R:Y607	11.4242	5.97	No	Yes	0	9	8
75	R:R:Q564	R:R:W565	15.011	12.05	Yes	Yes	1	3	9
76	R:R:P594	R:R:Q564	14.0346	4.74	No	Yes	0	1	3
77	R:R:I323	R:R:W322	20.3693	3.52	No	Yes	0	7	8
78	R:R:I323	R:R:Y369	16.6013	4.84	No	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8J9N_nogp

PDB Summary
PDB	8J9N_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	321
Number of Links	365
Number of Hubs	49
Number of Links mediated by Hubs	179
Number of Communities	8
Number of Nodes involved in Communities	67
Number of Links involved in Communities	93

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	111346
Length Of Smallest Path	3
Average Path Length	19.0504
Length of Longest Path	36
Minimum Path Strength	1.455
Average Path Strength	5.74378
Maximum Path Strength	16.725
Minimum Path Correlation	0.7
Average Path Correlation	0.940794
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	47.7494
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.3727
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UP38
Sequence	>8J9N_nogp_Chain_R S C P R A L K V P S Y L N Y H F L G E K D C G A P C E P T K V Y G L M Y F G P E E L R F S R T W I G I W S V L C C A S T L F T V L T Y L V D M R R F S Y P E R P I I F L S G C Y T A V A V A Y I A G F L L E D R V V C N D K F A E D G A R T V A Q G T K K E G C T I L F M M L Y F F S M A S S I W W V I L S L T W F L A A G M K W G H E A I E A N S Q Y F H L A A W A V P A I K T I T I L A L G Q V D G D V L S G V C F V G L N N V D A L R G F V L A P L F V Y L F I G T S F L L A G F V S L F R I R T I M K H D G T K T E K L E K L M V R I G V F S V L Y T V P A T I V I A C Y F Y E Q A F R D Q W E R S W V A Q S C K S Y A I P C P H L Q P H P P M S P D F T V F M I K Y L M T L I V G I T S G F W I W S G K T L N S W R K F Y T R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J9N	F	Protein	Frizzled	FZD₁	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	3.5	2024-01-17	doi.org/10.1038/s41421-023-00627-y
	8J9N (No Gprot)	F	Protein	Frizzled	FZD₁	Homo sapiens	-	-		3.5	2024-01-17	doi.org/10.1038/s41421-023-00627-y
	8J9O	F	Protein	Frizzled	FZD₁	Homo sapiens	-	-	-	3.4	2024-01-17	doi.org/10.1038/s41421-023-00627-y

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Download 8J9N_nogp.zip

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