psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P277	R:R:R278	5.76	No	No	0	9	3
2	R:R:E293	R:R:R278	10.47	No	No	8	5	3
3	R:R:C296	R:R:R278	5.57	No	No	8	9	3
4	R:R:L280	R:R:P299	6.57	No	No	0	4	7
5	R:R:P283	R:R:V282	3.53	No	Yes	1	3	5
6	R:R:V282	R:R:Y288	10.09	Yes	No	0	5	6
7	R:R:D295	R:R:V282	7.3	Yes	Yes	1	5	5
8	R:R:F385	R:R:V282	6.55	No	Yes	1	3	5
9	R:R:P283	R:R:Y285	4.17	No	No	0	3	3
10	R:R:F385	R:R:P283	5.78	No	No	1	3	3
11	R:R:K294	R:R:S284	4.59	No	No	1	1	2
12	R:R:D295	R:R:S284	4.42	Yes	No	1	5	2
13	R:R:L286	R:R:Y285	17.58	No	No	0	4	3
14	R:R:L286	R:R:Y288	14.07	No	No	0	4	6
15	R:R:K398	R:R:L286	8.46	No	No	0	7	4
16	R:R:H289	R:R:N287	3.83	No	No	0	4	4
17	R:R:Q395	R:R:Y288	5.64	No	No	0	6	6
18	R:R:H289	R:R:K294	5.24	No	No	0	4	1
19	R:R:F290	R:R:L291	9.74	No	Yes	0	6	4
20	R:R:C296	R:R:F290	4.19	No	No	0	9	6
21	R:R:E293	R:R:L291	6.63	No	Yes	0	5	4
22	R:R:E566	R:R:L291	6.63	No	Yes	0	6	4
23	R:R:L291	R:R:Q585	7.99	Yes	No	0	4	3
24	R:R:C296	R:R:E293	7.6	No	No	8	9	5
25	R:R:D295	R:R:K294	8.3	Yes	No	1	5	1
26	R:R:A298	R:R:M309	3.22	No	Yes	0	5	6
27	R:R:M309	R:R:P299	6.71	Yes	No	0	6	7
28	R:R:P299	R:R:Y577	12.52	No	Yes	0	7	4
29	R:R:C300	R:R:C381	7.28	No	No	10	9	9
30	R:R:E301	R:R:P302	7.86	No	No	0	4	3
31	R:R:E301	R:R:T303	8.47	No	No	0	4	3
32	R:R:E301	R:R:R391	3.49	No	No	0	4	4
33	R:R:L308	R:R:P302	3.28	Yes	No	0	5	3
34	R:R:P302	R:R:P313	3.9	No	No	0	3	3
35	R:R:A390	R:R:K304	3.21	No	No	0	3	4
36	R:R:K304	R:R:Y577	8.36	No	Yes	0	4	4
37	R:R:V305	R:R:Y306	5.05	No	No	0	3	2
38	R:R:S573	R:R:Y306	6.36	No	No	0	4	2
39	R:R:G307	R:R:Y577	4.35	No	Yes	0	8	4
40	R:R:F311	R:R:L308	3.65	Yes	Yes	0	7	5
41	R:R:L308	R:R:L316	5.54	Yes	No	0	5	5
42	R:R:L308	R:R:V472	5.96	Yes	No	0	5	5
43	R:R:M309	R:R:Y310	3.59	Yes	Yes	0	6	5
44	R:R:M309	R:R:W569	8.14	Yes	No	0	6	5
45	R:R:F311	R:R:Y310	5.16	Yes	Yes	11	7	5
46	R:R:P598	R:R:Y310	4.17	No	Yes	0	9	5
47	R:R:F603	R:R:Y310	4.13	No	Yes	11	6	5
48	R:R:E315	R:R:F311	5.83	No	Yes	0	7	7
49	R:R:F311	R:R:L473	7.31	Yes	No	0	7	8
50	R:R:F311	R:R:F600	9.65	Yes	No	0	7	6
51	R:R:F311	R:R:F603	6.43	Yes	No	11	7	6
52	R:R:G312	R:R:P313	4.06	No	No	0	5	3
53	R:R:E315	R:R:G312	3.27	No	No	0	7	5
54	R:R:F318	R:R:F600	4.29	No	No	0	7	6
55	R:R:L473	R:R:S319	4.5	No	No	0	8	7
56	R:R:F373	R:R:R320	4.28	No	No	0	6	5
57	R:R:D377	R:R:R320	4.76	No	No	0	6	5
58	R:R:G475	R:R:R320	4.5	No	No	0	9	5
59	R:R:W322	R:R:W326	10.31	No	Yes	4	8	7
60	R:R:M604	R:R:W322	5.82	No	No	0	7	8
61	R:R:L608	R:R:W322	11.39	No	No	4	7	8
62	R:R:I323	R:R:Y369	3.63	No	Yes	0	7	8
63	R:R:I323	R:R:Y607	3.63	No	Yes	0	7	8
64	R:R:F373	R:R:G324	4.52	No	No	0	6	5
65	R:R:L329	R:R:W326	4.56	No	Yes	4	6	7
66	R:R:L608	R:R:W326	6.83	No	Yes	4	7	7
67	R:R:I615	R:R:W326	3.52	No	Yes	4	8	7
68	R:R:S327	R:R:Y369	5.09	No	Yes	0	8	8
69	R:R:I370	R:R:S327	4.64	No	No	0	5	8
70	R:R:I615	R:R:L329	5.71	No	No	4	8	6
71	R:R:A366	R:R:C330	3.61	No	No	0	8	9
72	R:R:C330	R:R:L611	4.76	No	No	0	9	8
73	R:R:C330	R:R:I615	4.91	No	No	0	9	8
74	R:R:A366	R:R:C331	3.61	No	No	0	8	6
75	R:R:T334	R:R:T363	9.42	No	No	0	8	5
76	R:R:F336	R:R:T340	5.19	No	No	13	7	9
77	R:R:F336	R:R:W630	14.03	No	Yes	13	7	9
78	R:R:S359	R:R:T337	9.59	No	No	0	8	9
79	R:R:I621	R:R:T337	3.04	Yes	No	0	7	9
80	R:R:T340	R:R:W630	9.7	No	Yes	13	9	9
81	R:R:M345	R:R:Y341	7.18	No	No	0	5	9
82	R:R:R353	R:R:Y341	4.12	No	No	0	9	9
83	R:R:I356	R:R:Y341	18.13	No	No	0	8	9
84	R:R:V343	R:R:W630	3.68	No	Yes	0	7	9
85	R:R:F633	R:R:V343	3.93	No	No	0	6	7
86	R:R:D344	R:R:K632	4.15	No	No	0	9	4
87	R:R:F348	R:R:R347	5.34	No	Yes	0	9	9
88	R:R:K625	R:R:R347	3.71	No	Yes	0	9	9
89	R:R:R347	R:R:T626	6.47	Yes	No	0	9	9
90	R:R:R347	R:R:S629	9.22	Yes	No	0	9	8
91	R:R:F348	R:R:I356	3.77	No	No	0	9	8
92	R:R:F348	R:R:I621	5.02	No	Yes	0	9	7
93	R:R:P351	R:R:S349	7.13	Yes	No	0	9	5
94	R:R:R353	R:R:Y350	8.23	No	Yes	0	9	9
95	R:R:T426	R:R:Y350	7.49	No	Yes	6	9	9
96	R:R:I440	R:R:Y350	3.63	Yes	Yes	6	9	9
97	R:R:F447	R:R:Y350	8.25	No	Yes	0	9	9
98	R:R:P351	R:R:T426	3.5	Yes	No	6	9	9
99	R:R:I440	R:R:P351	3.39	Yes	Yes	6	9	9
100	R:R:L533	R:R:P351	6.57	No	Yes	0	9	9
101	R:R:E352	R:R:R536	10.47	No	Yes	0	9	9
102	R:R:P354	R:R:W419	6.76	No	Yes	0	9	9
103	R:R:L423	R:R:P354	4.93	No	No	0	9	9
104	R:R:F540	R:R:I355	20.09	No	No	5	9	9
105	R:R:I355	R:R:W620	5.87	No	Yes	5	9	9
106	R:R:F357	R:R:W419	23.05	No	Yes	2	8	9
107	R:R:F357	R:R:W452	5.01	No	No	2	8	9
108	R:R:F540	R:R:L358	3.65	No	No	0	9	8
109	R:R:S359	R:R:S617	3.26	No	No	0	8	9
110	R:R:G360	R:R:T363	3.64	No	No	0	6	5
111	R:R:C361	R:R:S416	3.44	No	No	0	9	8
112	R:R:V365	R:R:Y362	3.79	No	Yes	0	8	9
113	R:R:S416	R:R:Y362	7.63	No	Yes	0	8	9
114	R:R:V613	R:R:Y362	5.05	No	Yes	0	8	9
115	R:R:G614	R:R:Y362	4.35	No	Yes	0	9	9
116	R:R:A364	R:R:F412	9.71	No	No	0	5	9
117	R:R:V365	R:R:Y369	3.79	No	Yes	0	8	8
118	R:R:A368	R:R:L409	3.15	No	No	0	7	6
119	R:R:L409	R:R:Y369	5.86	No	Yes	0	6	8
120	R:R:V476	R:R:Y369	5.05	No	Yes	0	7	8
121	R:R:L611	R:R:Y369	7.03	No	Yes	0	8	8
122	R:R:L375	R:R:R378	4.86	No	No	0	5	4
123	R:R:L375	R:R:V379	8.94	No	Yes	0	5	6
124	R:R:D377	R:R:V380	4.38	No	No	0	6	7
125	R:R:V379	R:R:V380	3.21	Yes	No	0	6	7
126	R:R:C381	R:R:V380	3.42	No	No	0	9	7
127	R:R:D383	R:R:N382	4.04	No	No	0	3	6
128	R:R:F385	R:R:N382	9.67	No	No	0	3	6
129	R:R:D383	R:R:R391	3.57	No	No	0	3	4
130	R:R:D469	R:R:Q395	5.22	Yes	No	9	8	6
131	R:R:N482	R:R:Q395	10.56	No	No	9	5	6
132	R:R:T397	R:R:T403	4.71	No	No	0	6	8
133	R:R:G401	R:R:I404	3.53	No	No	0	4	5
134	R:R:C402	R:R:C477	7.28	Yes	No	3	9	9
135	R:R:F406	R:R:Y410	6.19	No	Yes	3	9	9
136	R:R:F406	R:R:V468	11.8	No	Yes	3	9	9
137	R:R:F406	R:R:V479	5.24	No	Yes	3	9	9
138	R:R:F478	R:R:L409	7.31	No	No	0	6	6
139	R:R:M414	R:R:Y410	4.79	No	Yes	0	9	9
140	R:R:I462	R:R:Y410	3.63	Yes	Yes	0	7	9
141	R:R:V479	R:R:Y410	12.62	Yes	Yes	3	9	9
142	R:R:F411	R:R:F412	8.57	Yes	No	0	8	9
143	R:R:F411	R:R:P455	7.22	Yes	Yes	0	8	9
144	R:R:F411	R:R:T459	6.49	Yes	No	0	8	9
145	R:R:A415	R:R:P455	3.74	No	Yes	0	9	9
146	R:R:S417	R:R:Y498	6.36	No	Yes	0	8	7
147	R:R:I418	R:R:V454	3.07	No	No	14	6	5
148	R:R:I418	R:R:P455	5.08	No	Yes	14	6	9
149	R:R:I418	R:R:Y498	8.46	No	Yes	0	6	7
150	R:R:I422	R:R:W419	5.87	No	Yes	2	6	9
151	R:R:H448	R:R:W419	4.23	No	Yes	2	9	9
152	R:R:A451	R:R:W419	9.08	No	Yes	2	9	9
153	R:R:W419	R:R:W452	4.69	Yes	No	2	9	9
154	R:R:G502	R:R:W420	4.22	No	Yes	0	9	9
155	R:R:W420	R:R:Y544	26.04	Yes	No	0	9	9
156	R:R:V421	R:R:Y498	3.79	No	Yes	0	9	7
157	R:R:A451	R:R:I422	3.25	No	No	2	9	6
158	R:R:G502	R:R:S424	3.71	No	No	0	9	8
159	R:R:F505	R:R:S424	5.28	No	No	0	9	8
160	R:R:I440	R:R:T426	6.08	Yes	No	6	9	9
161	R:R:A431	R:R:W427	3.89	No	Yes	0	9	9
162	R:R:L506	R:R:W427	3.42	No	Yes	0	8	9
163	R:R:G509	R:R:W427	4.22	No	Yes	0	9	9
164	R:R:F510	R:R:W427	17.04	No	Yes	0	8	9
165	R:R:I537	R:R:W427	3.52	No	Yes	0	9	9
166	R:R:A431	R:R:L530	3.15	No	No	0	9	9
167	R:R:G432	R:R:S512	3.71	No	No	0	8	8
168	R:R:M433	R:R:W435	12.8	No	No	0	6	9
169	R:R:K434	R:R:L530	4.23	No	No	0	9	9
170	R:R:A439	R:R:W435	5.19	No	No	0	9	9
171	R:R:E438	R:R:H437	11.08	No	No	0	9	7
172	R:R:N443	R:R:Y446	3.49	No	No	0	6	7
173	R:R:H448	R:R:S444	6.97	No	No	0	9	8
174	R:R:H448	R:R:W452	3.17	No	No	2	9	9
175	R:R:P455	R:R:V454	3.53	Yes	No	14	9	5
176	R:R:K458	R:R:P494	6.69	No	No	0	7	9
177	R:R:I462	R:R:Q467	4.12	Yes	Yes	0	7	6
178	R:R:F490	R:R:I462	7.54	No	Yes	0	8	7
179	R:R:D469	R:R:Q467	7.83	Yes	Yes	0	8	6
180	R:R:Q467	R:R:V479	5.73	Yes	Yes	0	6	9
181	R:R:A486	R:R:Q467	6.06	No	Yes	0	6	6
182	R:R:D469	R:R:L481	4.07	Yes	No	0	8	7
183	R:R:D469	R:R:N482	6.73	Yes	No	9	8	5
184	R:R:D471	R:R:L473	5.43	No	No	0	9	8
185	R:R:D471	R:R:S474	5.89	No	Yes	12	9	7
186	R:R:D471	R:R:Y607	8.05	No	Yes	12	9	8
187	R:R:S474	R:R:V476	4.85	Yes	No	0	7	7
188	R:R:S474	R:R:Y607	7.63	Yes	Yes	12	7	8
189	R:R:F478	R:R:V479	3.93	No	Yes	0	6	9
190	R:R:F478	R:R:K606	3.72	No	No	0	6	9
191	R:R:V479	R:R:V491	4.81	Yes	No	0	9	8
192	R:R:D485	R:R:N483	8.08	No	No	15	3	6
193	R:R:A486	R:R:N483	4.69	No	No	15	6	6
194	R:R:A486	R:R:D485	3.09	No	No	15	6	3
195	R:R:D485	R:R:F490	5.97	No	No	0	3	8
196	R:R:L487	R:R:Y555	9.38	No	Yes	7	8	4
197	R:R:E558	R:R:L487	7.95	No	No	7	9	8
198	R:R:L487	R:R:R562	3.64	No	Yes	7	8	7
199	R:R:G489	R:R:R488	9.01	No	No	0	4	7
200	R:R:L492	R:R:R488	3.64	No	No	0	8	7
201	R:R:V491	R:R:Y555	11.36	No	Yes	0	8	4
202	R:R:L492	R:R:Y555	7.03	No	Yes	0	8	4
203	R:R:L492	R:R:Q559	5.32	No	No	0	8	7
204	R:R:F496	R:R:F500	20.36	No	No	0	4	4
205	R:R:F496	R:R:I552	5.02	No	No	0	4	7
206	R:R:V497	R:R:Y498	3.79	No	Yes	0	5	7
207	R:R:A548	R:R:L499	3.15	No	No	0	8	8
208	R:R:F505	R:R:S504	3.96	No	No	0	9	5
209	R:R:L506	R:R:S541	4.5	No	No	0	8	8
210	R:R:G509	R:R:S512	3.71	No	No	0	9	8
211	R:R:F510	R:R:M534	4.98	No	No	0	8	9
212	R:R:L513	R:R:L530	4.15	No	No	0	8	9
213	R:R:L513	R:R:M534	7.07	No	No	0	8	9
214	R:R:F514	R:R:M534	4.98	No	No	0	7	9
215	R:R:E528	R:R:K529	8.1	No	No	0	6	9
216	R:R:K532	R:R:V535	4.55	No	No	0	8	7
217	R:R:K532	R:R:R536	4.95	No	Yes	0	8	9
218	R:R:R536	R:R:W620	18.99	Yes	Yes	5	9	9
219	R:R:I621	R:R:R536	3.76	Yes	Yes	5	7	9
220	R:R:V539	R:R:W620	3.68	No	Yes	0	5	9
221	R:R:F540	R:R:W620	13.03	No	Yes	5	9	9
222	R:R:L543	R:R:T616	10.32	No	No	0	8	8
223	R:R:L543	R:R:W620	3.42	No	Yes	0	8	9
224	R:R:V613	R:R:Y544	3.79	No	No	0	8	9
225	R:R:P547	R:R:V546	3.53	Yes	No	0	9	7
226	R:R:M609	R:R:P547	6.71	No	Yes	0	9	9
227	R:R:I612	R:R:P547	3.39	No	Yes	0	7	9
228	R:R:P547	R:R:V613	3.53	Yes	No	0	9	8
229	R:R:I550	R:R:T549	3.04	No	No	0	4	5
230	R:R:I550	R:R:M609	5.83	No	No	0	4	9
231	R:R:C554	R:R:V551	3.42	No	No	0	8	7
232	R:R:C554	R:R:I605	6.55	No	No	0	8	7
233	R:R:E558	R:R:Y555	4.49	No	Yes	7	9	4
234	R:R:K606	R:R:Y555	5.97	No	Yes	0	9	4
235	R:R:F556	R:R:Y557	5.16	No	No	0	4	9
236	R:R:F556	R:R:Q559	7.03	No	No	0	4	7
237	R:R:F561	R:R:Y557	7.22	No	No	0	4	9
238	R:R:V602	R:R:Y557	3.79	No	No	0	6	9
239	R:R:E558	R:R:R562	9.3	No	Yes	7	9	7
240	R:R:F561	R:R:W565	11.02	No	No	0	4	9
241	R:R:D563	R:R:E566	6.5	No	No	0	4	6
242	R:R:Q585	R:R:R567	17.52	No	No	0	3	2
243	R:R:S573	R:R:W569	12.36	No	No	0	4	5
244	R:R:S573	R:R:S576	4.89	No	No	0	4	1
245	R:R:C574	R:R:K575	4.85	No	No	16	9	3
246	R:R:C574	R:R:C581	7.28	No	No	16	9	9
247	R:R:C581	R:R:K575	4.85	No	No	16	9	3
248	R:R:S576	R:R:Y577	3.82	No	Yes	0	1	4
249	R:R:I579	R:R:Y577	3.63	No	Yes	0	5	4
250	R:R:I579	R:R:P580	3.39	No	No	0	5	5
251	R:R:D599	R:R:V602	5.84	No	No	0	5	6
252	R:R:K606	R:R:Y607	4.78	No	Yes	0	9	8
253	R:R:L608	R:R:M609	4.24	No	No	0	7	9
254	R:R:G614	R:R:S617	3.71	No	No	0	9	9
255	R:R:I621	R:R:W620	3.52	Yes	Yes	5	7	9
256	R:R:T626	R:R:W622	6.06	No	No	0	9	6
257	R:R:L627	R:R:W622	10.25	No	No	0	5	6
258	R:R:G624	R:R:S623	3.71	No	No	0	5	9
259	R:R:K625	R:R:S623	9.18	No	No	0	9	9
260	R:R:S623	R:R:T626	6.4	No	No	0	9	9
261	R:R:L627	R:R:R631	8.5	No	No	0	5	5
262	R:R:K632	R:R:S629	3.06	No	No	0	4	8
263	R:R:F290	R:R:G297	3.01	No	No	0	6	8
264	R:R:L495	R:R:S417	3	No	No	0	8	8
265	R:R:L506	R:R:S424	3	No	No	0	8	8
266	R:R:L335	R:R:V338	2.98	No	No	0	5	7
267	R:R:L280	R:R:T392	2.95	No	No	0	4	5
268	R:R:L335	R:R:T363	2.95	No	No	0	5	5
269	R:R:L499	R:R:T503	2.95	No	No	0	8	6
270	R:R:L507	R:R:T503	2.95	No	No	0	5	6
271	R:R:I550	R:R:I605	2.94	No	No	0	4	7
272	R:R:D344	R:R:V343	2.92	No	No	0	9	7
273	R:R:I404	R:R:M408	2.92	No	No	0	5	5
274	R:R:D599	R:R:T601	2.89	No	No	0	5	5
275	R:R:K458	R:R:M414	2.88	No	No	0	7	9
276	R:R:I355	R:R:L423	2.85	No	No	0	9	9
277	R:R:I440	R:R:L429	2.85	Yes	No	0	9	9
278	R:R:L495	R:R:M414	2.83	No	No	0	8	9
279	R:R:D295	R:R:K281	2.77	Yes	No	0	5	5
280	R:R:L375	R:R:L405	2.77	No	No	0	5	7
281	R:R:L425	R:R:L429	2.77	No	No	0	6	9
282	R:R:A508	R:R:F428	2.77	No	No	0	7	8
283	R:R:A493	R:R:R488	2.77	No	No	0	5	7
284	R:R:R562	R:R:V484	2.62	Yes	No	0	7	4
285	R:R:D388	R:R:E387	2.6	No	No	0	4	2
286	R:R:R317	R:R:T321	2.59	No	No	0	4	4
287	R:R:F505	R:R:I501	2.51	No	No	0	9	5
288	R:R:V570	R:R:W569	2.45	No	No	0	3	5
289	R:R:T545	R:R:W420	2.43	No	Yes	0	8	9
290	R:R:E566	R:R:R562	2.33	No	Yes	0	6	7
291	R:R:M596	R:R:W565	2.33	No	No	0	3	9
292	R:R:L339	R:R:W630	2.28	No	Yes	0	6	9
293	R:R:L499	R:R:W420	2.28	No	Yes	0	8	9
294	R:R:L429	R:R:W435	2.28	No	No	0	9	9
295	R:R:H437	R:R:R346	2.26	No	No	0	7	4
296	R:R:G372	R:R:G475	2.11	No	No	0	9	9
297	R:R:A386	R:R:G389	1.95	No	No	0	1	4
298	R:R:A390	R:R:G389	1.95	No	No	0	3	4
299	R:R:A439	R:R:G436	1.95	No	No	0	9	7
300	R:R:A508	R:R:G509	1.95	No	No	0	7	9
301	R:R:C581	R:R:P582	1.88	No	No	0	9	4
302	R:R:A430	R:R:P351	1.87	No	Yes	0	8	9
303	R:R:G618	R:R:S333	1.86	No	No	0	8	9
304	R:R:G475	R:R:S474	1.86	No	Yes	0	9	7
305	R:R:G538	R:R:S541	1.86	No	No	0	9	8
306	R:R:G618	R:R:S617	1.86	No	No	0	8	9
307	R:R:G401	R:R:V379	1.84	No	Yes	0	4	6
308	R:R:G470	R:R:V393	1.84	No	No	0	9	7
309	R:R:G396	R:R:V468	1.84	No	Yes	0	6	9
310	R:R:G480	R:R:V479	1.84	No	Yes	0	8	9
311	R:R:G614	R:R:T334	1.82	No	No	0	9	8
312	R:R:G466	R:R:T397	1.82	No	No	0	6	6
313	R:R:P598	R:R:S597	1.78	No	No	0	9	4
314	R:R:P582	R:R:V570	1.77	No	No	0	4	3
315	R:R:C300	R:R:V393	1.71	No	No	10	9	7
316	R:R:C331	R:R:V367	1.71	No	No	0	6	4
317	R:R:C402	R:R:V379	1.71	Yes	Yes	0	9	6
318	R:R:C381	R:R:V393	1.71	No	No	10	9	7
319	R:R:C402	R:R:V468	1.71	Yes	Yes	3	9	9
320	R:R:C477	R:R:V468	1.71	No	Yes	3	9	9
321	R:R:E400	R:R:G401	1.64	No	No	0	6	4
322	R:R:S413	R:R:S416	1.63	No	No	0	6	8
323	R:R:A279	R:R:I579	1.62	No	No	0	5	5
324	R:R:C402	R:R:K399	1.62	Yes	No	0	9	6
325	R:R:A450	R:R:I422	1.62	No	No	0	6	6
326	R:R:V542	R:R:V546	1.6	No	No	0	7	7
327	R:R:T610	R:R:V551	1.59	No	No	0	6	7
328	R:R:A371	R:R:L405	1.58	No	No	0	5	7
329	R:R:A453	R:R:L449	1.58	No	No	0	5	5
330	R:R:A394	R:R:N382	1.56	No	No	0	6	6
331	R:R:I457	R:R:T461	1.52	No	No	0	4	4
332	R:R:I462	R:R:T461	1.52	Yes	No	0	7	4
333	R:R:M407	R:R:T459	1.51	No	No	0	8	9
334	R:R:L342	R:R:V338	1.49	No	No	0	7	7
335	R:R:L463	R:R:V468	1.49	No	Yes	0	8	9
336	R:R:L463	R:R:T403	1.47	No	No	0	8	8
337	R:R:I460	R:R:L463	1.43	No	No	0	7	8
338	R:R:I552	R:R:L495	1.43	No	No	0	7	8
339	R:R:A456	R:R:F411	1.39	No	Yes	0	8	8
340	R:R:A553	R:R:F556	1.39	No	No	0	6	4
341	R:R:L465	R:R:Q467	1.33	No	Yes	0	5	6
342	R:R:E314	R:R:E315	1.27	No	No	0	4	7
343	R:R:E438	R:R:E441	1.27	No	No	0	9	8
344	R:R:S568	R:R:W565	1.24	No	No	0	4	9
345	R:R:F447	R:R:N443	1.21	No	No	0	9	6
346	R:R:Q572	R:R:Y306	1.13	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V282	6.8675	4	1	5
2	R:R:L291	7.7475	4	0	4
3	R:R:D295	5.6975	4	1	5
4	R:R:L308	4.6075	4	0	5
5	R:R:M309	5.415	4	0	6
6	R:R:Y310	4.2625	4	11	5
7	R:R:F311	6.33833	6	11	7
8	R:R:W326	6.305	4	4	7
9	R:R:R347	6.185	4	0	9
10	R:R:Y350	6.9	4	6	9
11	R:R:P351	4.492	5	6	9
12	R:R:Y362	5.205	4	0	9
13	R:R:Y369	5.075	6	0	8
14	R:R:V379	3.925	4	0	6
15	R:R:C402	3.08	4	3	9
16	R:R:Y410	6.8075	4	3	9
17	R:R:F411	5.9175	4	0	8
18	R:R:W419	8.94667	6	2	9
19	R:R:W420	8.7425	4	0	9
20	R:R:W427	6.418	5	0	9
21	R:R:I440	3.9875	4	6	9
22	R:R:P455	4.8925	4	14	9
23	R:R:I462	4.2025	4	0	7
24	R:R:Q467	5.014	5	0	6
25	R:R:V468	3.71	5	3	9
26	R:R:D469	5.9625	4	9	8
27	R:R:S474	5.0575	4	12	7
28	R:R:V479	5.695	6	3	9
29	R:R:Y498	5.6	4	0	7
30	R:R:R536	9.5425	4	5	9
31	R:R:P547	4.29	4	0	9
32	R:R:Y555	7.646	5	7	4
33	R:R:R562	4.4725	4	7	7
34	R:R:Y577	6.536	5	0	4
35	R:R:Y607	6.0225	4	12	8
36	R:R:W620	8.085	6	5	9
37	R:R:I621	3.835	4	5	7
38	R:R:W630	7.4225	4	13	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M309	R:R:P299	15.7136	6.71	Yes	No	0	6	7
2	R:R:M309	R:R:Y310	30.8732	3.59	Yes	Yes	0	6	5
3	R:R:F311	R:R:Y310	34.1452	5.16	Yes	Yes	11	7	5
4	R:R:F311	R:R:L473	49.7612	7.31	Yes	No	0	7	8
5	R:R:D471	R:R:L473	51.6584	5.43	No	No	0	9	8
6	R:R:D471	R:R:Y607	31.3376	8.05	No	Yes	12	9	8
7	R:R:K606	R:R:Y607	33.1214	4.78	No	Yes	0	9	8
8	R:R:K606	R:R:Y555	41.7869	5.97	No	Yes	0	9	4
9	R:R:L487	R:R:Y555	17.3523	9.38	No	Yes	7	8	4
10	R:R:L487	R:R:R562	16.2097	3.64	No	Yes	7	8	7
11	R:R:E566	R:R:R562	28.0418	2.33	No	Yes	0	6	7
12	R:R:E566	R:R:L291	23.3765	6.63	No	Yes	0	6	4
13	R:R:E558	R:R:Y555	17.4816	4.49	No	Yes	7	9	4
14	R:R:E558	R:R:R562	16.3443	9.3	No	Yes	7	9	7
15	R:R:V491	R:R:Y555	10.204	11.36	No	Yes	0	8	4
16	R:R:V479	R:R:V491	10.5259	4.81	Yes	No	0	9	8
17	R:R:Q467	R:R:V479	19.6137	5.73	Yes	Yes	0	6	9
18	R:R:D469	R:R:Q467	14.9379	7.83	Yes	Yes	0	8	6
19	R:R:D469	R:R:Q395	12.497	5.22	Yes	No	9	8	6
20	R:R:Q395	R:R:Y288	11.7661	5.64	No	No	0	6	6
21	R:R:P299	R:R:Y577	12.2041	12.52	No	Yes	0	7	4
22	R:R:G475	R:R:R320	11.0748	4.5	No	No	0	9	5
23	R:R:G475	R:R:S474	12.5155	1.86	No	Yes	0	9	7
24	R:R:F406	R:R:V468	15.3891	11.8	No	Yes	3	9	9
25	R:R:F406	R:R:V479	14.046	5.24	No	Yes	3	9	9
26	R:R:F311	R:R:L308	11.9033	3.65	Yes	Yes	0	7	5
27	R:R:M309	R:R:W569	13.3678	8.14	Yes	No	0	6	5
28	R:R:F478	R:R:K606	25.6511	3.72	No	No	0	6	9
29	R:R:F478	R:R:L409	46.8823	7.31	No	No	0	6	6
30	R:R:L409	R:R:Y369	47.2518	5.86	No	Yes	0	6	8
31	R:R:L611	R:R:Y369	10.6367	7.03	No	Yes	0	8	8
32	R:R:I323	R:R:Y607	36.1163	3.63	No	Yes	0	7	8
33	R:R:I323	R:R:Y369	36.1717	3.63	No	Yes	0	7	8
34	R:R:V365	R:R:Y369	100	3.79	No	Yes	0	8	8
35	R:R:V365	R:R:Y362	99.5198	3.79	No	Yes	0	8	9
36	R:R:G614	R:R:Y362	73.0902	4.35	No	Yes	0	9	9
37	R:R:F348	R:R:R347	20.6085	5.34	No	Yes	0	9	9
38	R:R:F348	R:R:I621	44.8743	5.02	No	Yes	0	9	7
39	R:R:I621	R:R:T337	63.7992	3.04	Yes	No	0	7	9
40	R:R:S359	R:R:T337	64.6436	9.59	No	No	0	8	9
41	R:R:S359	R:R:S617	65.4379	3.26	No	No	0	8	9
42	R:R:G614	R:R:S617	67.789	3.71	No	No	0	9	9
43	R:R:I356	R:R:Y341	24.6642	18.13	No	No	0	8	9
44	R:R:F348	R:R:I356	25.6696	3.77	No	No	0	9	8
45	R:R:R353	R:R:Y341	22.6456	4.12	No	No	0	9	9
46	R:R:R353	R:R:Y350	21.6693	8.23	No	Yes	0	9	9
47	R:R:I440	R:R:Y350	12.1118	3.63	Yes	Yes	6	9	9
48	R:R:I621	R:R:W620	18.1809	3.52	Yes	Yes	5	7	9
49	R:R:I355	R:R:W620	11.9614	5.87	No	Yes	5	9	9
50	R:R:I355	R:R:L423	10.9428	2.85	No	No	0	9	9
51	R:R:V613	R:R:Y362	43.7739	5.05	No	Yes	0	8	9
52	R:R:S417	R:R:Y498	11.7635	6.36	No	Yes	0	8	7
53	R:R:L495	R:R:S417	12.6316	3	No	No	0	8	8
54	R:R:L495	R:R:M414	16.0514	2.83	No	No	0	8	9
55	R:R:M414	R:R:Y410	18.5608	4.79	No	Yes	0	9	9
56	R:R:V479	R:R:Y410	18.5107	12.62	Yes	Yes	3	9	9
57	R:R:S474	R:R:V476	26.2079	4.85	Yes	No	0	7	7
58	R:R:G502	R:R:W420	24.9334	4.22	No	Yes	0	9	9
59	R:R:W420	R:R:Y544	30.9972	26.04	Yes	No	0	9	9
60	R:R:V613	R:R:Y544	31.9893	3.79	No	No	0	8	9
61	R:R:G502	R:R:S424	23.9043	3.71	No	No	0	9	8
62	R:R:L506	R:R:W427	16.5501	3.42	No	Yes	0	8	9
63	R:R:L506	R:R:S424	19.7351	3	No	No	0	8	8
64	R:R:L492	R:R:Y555	18.2046	7.03	No	Yes	0	8	4
65	R:R:L492	R:R:Q559	13.4654	5.32	No	No	0	8	7
66	R:R:P547	R:R:V613	13.5763	3.53	Yes	No	0	9	8
67	R:R:F556	R:R:Q559	12.2675	7.03	No	No	0	4	7
68	R:R:F478	R:R:V479	36.929	3.93	No	Yes	0	6	9
69	R:R:D471	R:R:S474	21.2893	5.89	No	Yes	12	9	7
70	R:R:V476	R:R:Y369	26.4348	5.05	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8J9O

PDB Summary
PDB	8J9O
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.4
Date	2024-01-17
D.O.I.	10.1038/s41421-023-00627-y

Net Summary
I_min	3.04
Number of Linked Nodes	314
Number of Links	346
Number of Hubs	38
Number of Links mediated by Hubs	150
Number of Communities	16
Number of Nodes involved in Communities	63
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	68873
Length Of Smallest Path	3
Average Path Length	15.6244
Length of Longest Path	31
Minimum Path Strength	1.45
Average Path Strength	5.54237
Maximum Path Strength	16.065
Minimum Path Correlation	0.7
Average Path Correlation	0.935444
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	48.9708
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.0607
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • protein binding • signaling receptor binding • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • Wnt receptor activity • G protein-coupled receptor activity • PDZ domain binding • protein domain specific binding • G protein-coupled receptor binding • frizzled binding • Wnt-protein binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • regulation of cellular process • negative regulation of biological process • RNA metabolic process • regulation of primary metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • regulation of cellular process • negative regulation of biological process • RNA metabolic process • regulation of primary metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • negative regulation of cellular process • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of DNA-templated transcription • regulation of biological process • negative regulation of metabolic process • biological regulation • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • negative regulation of RNA metabolic process • response to stimulus • response to chemical • response to xenobiotic stimulus • astrocyte-dopaminergic neuron signaling • glial cell-neuron signaling • signaling • cell-cell signaling • cell communication • cellular response to stimulus • cell surface receptor signaling pathway • canonical Wnt signaling pathway • signal transduction • Wnt signaling pathway • non-canonical Wnt signaling pathway • multicellular organismal process • regulation of cellular component organization • regulation of presynapse assembly • cellular component organization • cellular component biogenesis • multicellular organism development • cellular component assembly • regulation of presynapse organization • cell junction assembly • anatomical structure development • regulation of synapse structure or activity • regulation of synapse assembly • synapse organization • cellular component organization or biogenesis • regulation of biological quality • system development • developmental process • presynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • presynapse assembly • positive regulation of DNA-binding transcription factor activity • positive regulation of molecular function • regulation of molecular function • regulation of DNA-binding transcription factor activity • negative regulation of signaling • regulation of canonical Wnt signaling pathway • regulation of signal transduction • negative regulation of cell communication • negative regulation of Wnt signaling pathway • regulation of signaling • regulation of Wnt signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of canonical Wnt signaling pathway • regulation of response to stimulus • regulation of cell communication • heart development • cardiac chamber morphogenesis • animal organ development • heart morphogenesis • ventricular septum development • circulatory system development • anatomical structure morphogenesis • cardiac septum development • cardiac septum morphogenesis • ventricular septum morphogenesis • cardiac chamber development • membranous septum morphogenesis • animal organ morphogenesis • cardiac ventricle development • hard palate development • secondary palate development • roof of mouth development • cellular developmental process • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • muscle structure development • muscle organ development • tissue development • muscle tissue morphogenesis • tissue morphogenesis • muscular septum morphogenesis • muscle organ morphogenesis • cell surface receptor protein serine/threonine kinase signaling pathway • cellular response to growth factor stimulus • regulation of transmembrane receptor protein serine/threonine kinase signaling pathway • negative regulation of cellular response to growth factor stimulus • negative regulation of BMP signaling pathway • cellular response to endogenous stimulus • BMP signaling pathway • enzyme-linked receptor protein signaling pathway • cellular response to BMP stimulus • regulation of BMP signaling pathway • response to endogenous stimulus • regulation of cellular response to growth factor stimulus • response to BMP • transforming growth factor beta receptor superfamily signaling pathway • response to growth factor • negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway • epithelium development • endothelial cell differentiation • endothelium development • epithelial cell differentiation • autocrine signaling • regulation of neuron projection development • positive regulation of cellular component organization • cell projection organization • positive regulation of biological process • cell development • neuron projection development • positive regulation of neuron projection development • positive regulation of cell projection organization • positive regulation of cellular process • plasma membrane bounded cell projection organization • regulation of cell projection organization • neuron development • regulation of plasma membrane bounded cell projection organization • regulation of osteoblast differentiation • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • positive regulation of DNA-templated transcription • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of nucleobase-containing compound metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • head development • dopaminergic neuron differentiation • brain development • central nervous system neuron differentiation • central nervous system development • midbrain development • midbrain dopaminergic neuron differentiation • intrinsic apoptotic signaling pathway in response to oxidative stress • neuron apoptotic process • regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • negative regulation of neuron apoptotic process • negative regulation of intracellular signal transduction • regulation of programmed cell death • regulation of intrinsic apoptotic signaling pathway • intracellular signal transduction • regulation of intracellular signal transduction • negative regulation of apoptotic signaling pathway • intrinsic apoptotic signaling pathway • regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • cell death • neuron intrinsic apoptotic signaling pathway in response to oxidative stress • apoptotic signaling pathway • negative regulation of intrinsic apoptotic signaling pathway • negative regulation of apoptotic process • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • apoptotic process • programmed cell death • regulation of neuron apoptotic process • regulation of apoptotic signaling pathway • stem cell differentiation • regulation of stem cell differentiation • mesenchymal stem cell differentiation • regulation of mesenchymal stem cell differentiation • outflow tract morphogenesis • cellular anatomical structure • periplasmic space • anchoring junction • cell junction • focal adhesion • cell-substrate junction • cell surface • cell periphery • plasma membrane • membrane • protein-containing complex • Wnt signalosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UP38
Sequence	>8J9O_Chain_R P R A L K V P S Y L N Y H F L G E K D C G A P C E P T K V Y G L M Y F G P E E L R F S R T W I G I W S V L C C A S T L F T V L T Y L V D M R R F S Y P E R P I I F L S G C Y T A V A V A Y I A G F L L E D R V V C N D K F A E D G A R T V A Q G T K K E G C T I L F M M L Y F F S M A S S I W W V I L S L T W F L A A G M K W G H E A I E A N S Q Y F H L A A W A V P A I K T I T I L A L G Q V D G D V L S G V C F V G L N N V D A L R G F V L A P L F V Y L F I G T S F L L A G F V S L F E K L E K L M V R I G V F S V L Y T V P A T I V I A C Y F Y E Q A F R D Q W E R S W V A Q S C K S Y A I P C P H L Q M S P D F T V F M I K Y L M T L I V G I T S G F W I W S G K T L N S W R K F Y T R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J9N	F	Protein	Frizzled	FZD₁	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	3.5	2024-01-17	10.1038/s41421-023-00627-y
	8J9N (No Gprot)	F	Protein	Frizzled	FZD₁	Homo sapiens	-	-		3.5	2024-01-17	10.1038/s41421-023-00627-y

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Download 8J9O.zip

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