psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R22	5.96	Yes	No	0	0	5
2	L:L:?1	R:R:V83	11.7	Yes	No	0	0	6
3	L:L:?1	R:R:F107	10.76	Yes	No	3	0	6
4	L:L:?1	R:R:I178	4.2	Yes	No	0	0	3
5	L:L:?1	R:R:F180	4.78	Yes	No	0	0	4
6	L:L:?1	R:R:Y284	5.75	Yes	Yes	3	0	7
7	R:R:C18	R:R:V20	3.42	No	No	0	8	2
8	R:R:C18	R:R:C183	7.28	No	No	0	8	1
9	R:R:C19	R:R:F21	6.98	No	Yes	0	3	3
10	R:R:C19	R:R:C266	7.28	No	No	0	3	6
11	R:R:D23	R:R:V20	8.76	No	No	0	5	2
12	R:R:S181	R:R:V20	3.23	No	No	0	5	2
13	R:R:D24	R:R:F21	10.75	No	Yes	1	4	3
14	R:R:F21	R:R:R270	10.69	Yes	Yes	1	3	2
15	R:R:F277	R:R:R22	26.72	Yes	No	0	5	5
16	R:R:L280	R:R:R22	3.64	Yes	No	0	5	5
17	R:R:D23	R:R:N171	5.39	No	No	0	5	2
18	R:R:D23	R:R:V176	4.38	No	No	0	5	1
19	R:R:D24	R:R:R270	7.15	No	Yes	1	4	2
20	R:R:F25	R:R:V29	14.42	Yes	Yes	1	5	4
21	R:R:F25	R:R:Y87	10.32	Yes	Yes	1	5	5
22	R:R:F25	R:R:L274	9.74	Yes	No	1	5	3
23	R:R:F25	R:R:F277	8.57	Yes	Yes	1	5	5
24	R:R:I26	R:R:R270	5.01	No	Yes	0	4	2
25	R:R:A27	R:R:Y87	4	No	Yes	0	4	5
26	R:R:K28	R:R:L30	7.05	No	No	0	3	6
27	R:R:P31	R:R:V29	7.07	No	Yes	0	6	4
28	R:R:V29	R:R:Y87	17.66	Yes	Yes	1	4	5
29	R:R:F277	R:R:V29	6.55	Yes	Yes	1	5	4
30	R:R:L30	R:R:P32	6.57	No	No	0	6	4
31	R:R:L30	R:R:V33	4.47	No	No	0	6	6
32	R:R:P31	R:R:P32	5.84	No	No	0	6	4
33	R:R:M84	R:R:P31	5.03	No	No	0	7	6
34	R:R:E37	R:R:M285	4.06	No	No	0	7	5
35	R:R:E37	R:R:M288	10.83	No	No	0	7	6
36	R:R:F40	R:R:M288	3.73	No	No	0	5	6
37	R:R:I77	R:R:L42	4.28	No	No	0	5	6
38	R:R:D73	R:R:N45	10.77	No	Yes	0	9	9
39	R:R:N45	R:R:P291	6.52	Yes	No	0	9	9
40	R:R:A48	R:R:Y295	4	No	Yes	0	8	5
41	R:R:F74	R:R:L49	15.83	Yes	No	0	7	7
42	R:R:H55	R:R:I51	9.28	No	No	0	5	7
43	R:R:F52	R:R:L56	3.65	Yes	No	0	7	6
44	R:R:F52	R:R:R63	4.28	Yes	Yes	4	7	7
45	R:R:F52	R:R:L66	4.87	Yes	Yes	4	7	8
46	R:R:F52	R:R:Y295	7.22	Yes	Yes	4	7	5
47	R:R:L56	R:R:W59	9.11	No	No	0	6	6
48	R:R:N141	R:R:W59	3.39	No	No	0	3	6
49	R:R:F65	R:R:S61	6.61	No	No	0	6	7
50	R:R:I139	R:R:S61	6.19	No	No	0	7	7
51	R:R:A144	R:R:S61	3.42	No	No	0	8	7
52	R:R:D124	R:R:S62	5.89	No	No	6	8	8
53	R:R:R128	R:R:S62	3.95	No	No	6	8	8
54	R:R:L66	R:R:R63	3.64	Yes	Yes	4	8	7
55	R:R:R63	R:R:S298	3.95	Yes	No	0	7	8
56	R:R:I64	R:R:N141	4.25	No	No	0	6	3
57	R:R:A144	R:R:I64	4.87	No	No	0	8	6
58	R:R:F65	R:R:V120	9.18	No	No	0	6	6
59	R:R:L66	R:R:Y294	4.69	Yes	No	0	8	9
60	R:R:L66	R:R:Y295	9.38	Yes	Yes	4	8	5
61	R:R:F67	R:R:V71	7.87	No	No	0	6	5
62	R:R:F117	R:R:N68	18.12	No	No	7	7	9
63	R:R:N68	R:R:S148	8.94	No	No	0	9	6
64	R:R:N68	R:R:W152	6.78	No	Yes	7	9	9
65	R:R:L118	R:R:L69	4.15	No	No	0	8	9
66	R:R:L69	R:R:Y295	3.52	No	Yes	0	9	5
67	R:R:A70	R:R:Y295	4	No	Yes	0	8	5
68	R:R:D73	R:R:S287	10.31	No	No	0	9	8
69	R:R:D290	R:R:D73	3.99	No	No	0	9	9
70	R:R:L76	R:R:N110	5.49	No	No	0	6	8
71	R:R:L76	R:R:S287	4.5	No	No	0	6	8
72	R:R:C79	R:R:V103	3.42	No	No	0	6	5
73	R:R:C79	R:R:M106	6.48	No	No	0	6	5
74	R:R:C79	R:R:F107	8.38	No	No	0	6	6
75	R:R:L80	R:R:P81	3.28	No	No	0	8	9
76	R:R:L80	R:R:V83	4.47	No	No	0	8	6
77	R:R:F82	R:R:P81	5.78	No	No	0	6	9
78	R:R:F82	R:R:V103	5.24	No	No	0	6	5
79	R:R:D85	R:R:M84	5.54	No	No	0	4	7
80	R:R:D85	R:R:V88	8.76	No	No	0	4	3
81	R:R:W93	R:R:Y86	11.58	Yes	No	0	9	5
82	R:R:R90	R:R:Y87	6.17	No	Yes	0	3	5
83	R:R:D92	R:R:R89	10.72	No	No	0	3	4
84	R:R:K94	R:R:R89	11.14	No	No	0	3	4
85	R:R:D92	R:R:N175	8.08	No	No	0	3	3
86	R:R:F95	R:R:W93	8.02	No	Yes	0	7	9
87	R:R:C100	R:R:W93	3.92	No	Yes	5	9	9
88	R:R:C177	R:R:W93	10.45	No	Yes	5	9	9
89	R:R:F95	R:R:P99	8.67	No	No	0	7	5
90	R:R:D97	R:R:R101	15.48	No	No	8	3	7
91	R:R:D97	R:R:K166	9.68	No	No	8	3	5
92	R:R:I98	R:R:P99	3.39	No	No	0	1	5
93	R:R:C100	R:R:C177	7.28	No	No	5	9	9
94	R:R:K166	R:R:R101	4.95	No	No	8	5	7
95	R:R:L104	R:R:S179	6.01	No	No	0	5	5
96	R:R:F105	R:R:M106	3.73	Yes	No	0	5	5
97	R:R:F105	R:R:M109	7.46	Yes	No	0	5	5
98	R:R:F105	R:R:L163	14.61	Yes	No	0	5	4
99	R:R:F107	R:R:Y284	16.5	No	Yes	3	6	7
100	R:R:A108	R:R:T159	5.03	No	No	0	5	6
101	R:R:M109	R:R:V156	4.56	No	No	0	5	4
102	R:R:N110	R:R:Y284	4.65	No	Yes	0	8	7
103	R:R:F193	R:R:R111	9.62	Yes	No	0	5	7
104	R:R:E196	R:R:R111	4.65	No	No	0	6	7
105	R:R:Q112	R:R:T155	4.25	No	No	0	7	7
106	R:R:M192	R:R:Q112	8.16	No	No	0	5	7
107	R:R:E196	R:R:Q112	11.47	No	No	0	6	7
108	R:R:E196	R:R:I115	10.93	No	Yes	0	6	8
109	R:R:I115	R:R:P200	3.39	Yes	No	0	8	9
110	R:R:F240	R:R:I115	6.28	No	Yes	9	9	8
111	R:R:F244	R:R:I115	8.79	No	Yes	9	9	8
112	R:R:F117	R:R:L151	4.87	No	No	0	7	7
113	R:R:F117	R:R:W152	12.03	No	Yes	7	7	9
114	R:R:P200	R:R:T119	3.5	No	No	0	9	7
115	R:R:I203	R:R:T119	4.56	No	No	0	6	7
116	R:R:R125	R:R:V121	7.85	No	No	0	9	8
117	R:R:D124	R:R:R128	10.72	No	No	6	8	8
118	R:R:I233	R:R:R125	5.01	No	No	0	7	9
119	R:R:R125	R:R:Y294	11.32	No	No	0	9	9
120	R:R:F127	R:R:Y126	4.13	No	Yes	2	5	8
121	R:R:V130	R:R:Y126	12.62	No	Yes	2	7	8
122	R:R:H131	R:R:Y126	3.27	No	Yes	2	6	8
123	R:R:F206	R:R:Y126	6.19	No	Yes	2	3	8
124	R:R:C207	R:R:Y126	6.72	No	Yes	0	6	8
125	R:R:R210	R:R:Y126	4.12	No	Yes	2	4	8
126	R:R:F127	R:R:H134	7.92	No	No	2	5	5
127	R:R:F127	R:R:L136	8.53	No	No	2	5	4
128	R:R:I211	R:R:V129	7.68	No	No	0	8	8
129	R:R:L215	R:R:V129	4.47	No	No	0	8	8
130	R:R:H131	R:R:V130	8.3	No	No	2	6	7
131	R:R:H134	R:R:L136	3.86	No	No	2	5	4
132	R:R:I146	R:R:W142	4.7	No	No	0	3	4
133	R:R:T155	R:R:W152	3.64	No	Yes	0	7	9
134	R:R:H161	R:R:L162	6.43	No	No	0	8	3
135	R:R:H189	R:R:L162	15.43	No	No	0	5	3
136	R:R:G172	R:R:N171	5.09	No	No	0	3	2
137	R:R:I178	R:R:S181	10.84	No	No	0	3	5
138	R:R:F180	R:R:S179	9.25	No	No	0	4	5
139	R:R:F180	R:R:H189	7.92	No	No	0	4	5
140	R:R:I182	R:R:R187	7.52	No	No	0	2	1
141	R:R:H184	R:R:T185	4.11	No	No	0	3	4
142	R:R:F186	R:R:W188	6.01	No	No	0	3	4
143	R:R:E190	R:R:F186	20.99	Yes	No	0	4	3
144	R:R:A191	R:R:F186	4.16	No	No	0	2	3
145	R:R:H189	R:R:M192	10.51	No	No	0	5	5
146	R:R:E190	R:R:R251	5.82	Yes	Yes	0	4	6
147	R:R:F193	R:R:S247	6.61	Yes	No	0	5	6
148	R:R:F193	R:R:V248	6.55	Yes	Yes	0	5	8
149	R:R:F193	R:R:R251	25.66	Yes	Yes	0	5	6
150	R:R:L195	R:R:L199	5.54	No	No	0	5	5
151	R:R:F197	R:R:F198	6.43	Yes	No	0	8	4
152	R:R:F197	R:R:L201	4.87	Yes	No	0	8	6
153	R:R:F197	R:R:L245	7.31	Yes	No	0	8	5
154	R:R:F197	R:R:V248	7.87	Yes	Yes	0	8	8
155	R:R:L199	R:R:P200	3.28	No	No	0	5	9
156	R:R:F240	R:R:L201	7.31	No	No	0	9	6
157	R:R:F206	R:R:R210	7.48	No	No	2	3	4
158	R:R:R210	R:R:W213	5	No	No	0	4	4
159	R:R:I212	R:R:I230	7.36	No	No	0	5	5
160	R:R:I226	R:R:L215	5.71	Yes	No	0	7	8
161	R:R:D221	R:R:R216	11.91	No	No	0	3	4
162	R:R:K227	R:R:R216	3.71	No	No	0	5	4
163	R:R:M220	R:R:R218	6.2	No	No	0	3	6
164	R:R:Q219	R:R:R222	4.67	No	No	0	4	4
165	R:R:D221	R:R:R222	9.53	No	No	0	3	4
166	R:R:P299	R:R:R228	5.76	No	No	0	5	7
167	R:R:A229	R:R:I230	3.25	No	No	0	8	5
168	R:R:F232	R:R:T231	6.49	Yes	No	0	7	6
169	R:R:F232	R:R:V235	3.93	Yes	No	0	7	5
170	R:R:F232	R:R:S297	15.85	Yes	No	0	7	6
171	R:R:V236	R:R:Y294	12.62	No	No	0	7	9
172	R:R:L289	R:R:V239	5.96	No	No	0	7	7
173	R:R:F240	R:R:F244	10.72	No	No	9	9	9
174	R:R:L245	R:R:V241	4.47	No	No	0	5	4
175	R:R:C243	R:R:F244	8.38	No	No	0	8	9
176	R:R:P246	R:R:T279	5.25	No	No	0	9	6
177	R:R:F282	R:R:P246	8.67	No	No	0	7	9
178	R:R:F276	R:R:V250	5.24	Yes	No	0	4	4
179	R:R:I254	R:R:R251	3.76	No	Yes	0	5	6
180	R:R:F276	R:R:R251	5.34	Yes	Yes	0	4	6
181	R:R:H253	R:R:L257	7.71	No	No	0	5	2
182	R:R:N265	R:R:Y269	16.28	No	Yes	0	4	4
183	R:R:C266	R:R:Y269	4.03	No	Yes	0	6	4
184	R:R:S271	R:R:V268	4.85	No	No	0	2	1
185	R:R:D273	R:R:Y269	5.75	No	Yes	0	4	4
186	R:R:D273	R:R:R270	3.57	No	Yes	0	4	2
187	R:R:L274	R:R:R270	6.07	No	Yes	1	3	2
188	R:R:F277	R:R:L274	3.65	Yes	No	1	5	3
189	R:R:F276	R:R:T279	5.19	Yes	No	0	4	6
190	R:R:F276	R:R:L280	7.31	Yes	Yes	0	4	5
191	R:R:L280	R:R:T283	4.42	Yes	No	3	5	8
192	R:R:L280	R:R:Y284	4.69	Yes	Yes	3	5	7
193	R:R:F282	R:R:S281	3.96	No	No	0	7	5
194	R:R:F282	R:R:M285	6.22	No	No	0	7	5
195	R:R:T283	R:R:Y284	11.24	No	Yes	3	8	7
196	R:R:N286	R:R:S287	5.96	No	No	0	9	8
197	R:R:D290	R:R:N286	12.12	No	No	0	9	9
198	R:R:P291	R:R:Y295	4.17	No	Yes	0	9	5
199	R:R:F296	R:R:V292	6.55	No	No	0	7	6
200	R:R:P299	R:R:S298	3.56	No	No	0	5	8
201	R:R:S298	R:R:S300	3.26	No	No	0	8	6
202	R:R:S140	R:R:T143	3.2	No	No	0	6	3
203	R:R:S261	R:R:T260	3.2	No	No	0	4	1
204	R:R:C53	R:R:L49	3.17	No	No	0	2	7
205	R:R:I233	R:R:S208	3.1	No	No	0	7	8
206	R:R:I169	R:R:V176	3.07	No	No	0	1	1
207	R:R:M234	R:R:S208	3.07	No	No	0	5	8
208	R:R:I252	R:R:V248	3.07	No	Yes	0	6	8
209	R:R:H133	R:R:P132	3.05	No	No	0	5	8
210	R:R:I204	R:R:T119	3.04	No	No	0	8	7
211	R:R:F74	R:R:G46	3.01	Yes	No	0	7	1
212	R:R:L56	R:R:S58	3	No	No	0	6	6
213	R:R:L69	R:R:S114	3	No	No	0	9	9
214	R:R:L34	R:R:V33	2.98	No	No	0	8	6
215	R:R:L194	R:R:V248	2.98	No	Yes	0	4	8
216	R:R:I226	R:R:I230	2.94	Yes	No	0	7	5
217	R:R:N175	R:R:T173	2.92	No	No	0	3	5
218	R:R:I212	R:R:M234	2.92	No	No	0	5	5
219	R:R:I226	R:R:M220	2.92	Yes	No	0	7	3
220	R:R:I226	R:R:K225	2.91	Yes	No	0	7	5
221	R:R:I78	R:R:L75	2.85	No	No	0	4	6
222	R:R:I116	R:R:L151	2.85	No	No	0	5	7
223	R:R:I147	R:R:L151	2.85	No	No	0	4	7
224	R:R:I154	R:R:L150	2.85	No	No	0	4	3
225	R:R:G46	R:R:W50	2.81	No	No	0	1	4
226	R:R:G113	R:R:W152	2.81	No	Yes	0	6	9
227	R:R:D221	R:R:I226	2.8	No	Yes	0	3	7
228	R:R:L201	R:R:L205	2.77	No	No	0	6	4
229	R:R:I169	R:R:Q170	2.74	No	No	0	1	2
230	R:R:R228	R:R:S297	2.64	No	No	0	7	6
231	R:R:F232	R:R:V293	2.62	Yes	No	0	7	7
232	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
233	R:R:F105	R:R:T159	2.59	Yes	No	0	5	6
234	R:R:H134	R:R:N137	2.55	No	No	0	5	4
235	R:R:S261	R:R:Y269	2.54	No	Yes	0	4	4
236	R:R:V176	R:R:Y86	2.52	No	No	0	1	5
237	R:R:V268	R:R:Y269	2.52	No	Yes	0	1	4
238	R:R:F38	R:R:I39	2.51	No	No	0	6	5
239	R:R:F74	R:R:I77	2.51	Yes	No	0	7	5
240	R:R:S140	R:R:W142	2.47	No	No	0	6	4
241	R:R:V71	R:R:W152	2.45	No	Yes	0	5	9
242	R:R:F38	R:R:L80	2.44	No	No	0	6	8
243	R:R:L163	R:R:R101	2.43	No	No	0	4	7
244	R:R:F74	R:R:N45	2.42	Yes	Yes	0	7	9
245	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	8
246	R:R:N137	R:R:R128	2.41	No	No	0	4	8
247	R:R:E267	R:R:F21	2.33	No	Yes	0	1	3
248	R:R:E190	R:R:F255	2.33	Yes	No	0	4	5
249	R:R:L47	R:R:W50	2.28	No	No	0	5	4
250	R:R:Q217	R:R:W213	2.19	No	No	0	5	4
251	R:R:G96	R:R:P99	2.03	No	No	0	8	5
252	R:R:G157	R:R:V160	1.84	No	No	0	4	4
253	R:R:G35	R:R:M84	1.75	No	No	0	5	7
254	R:R:G44	R:R:L43	1.71	No	No	0	7	4
255	R:R:C207	R:R:V123	1.71	No	No	0	6	6
256	R:R:G41	R:R:N45	1.7	No	Yes	0	8	9
257	R:R:C243	R:R:I242	1.64	No	No	0	8	5
258	R:R:A122	R:R:I204	1.62	No	No	0	9	8
259	R:R:S214	R:R:V130	1.62	No	No	0	5	7
260	R:R:A237	R:R:I204	1.62	No	No	0	7	8
261	R:R:V239	R:R:V293	1.6	No	No	0	7	7
262	R:R:V249	R:R:V250	1.6	No	No	0	5	4
263	R:R:V292	R:R:V293	1.6	No	No	0	6	7
264	R:R:C100	R:R:L168	1.59	No	No	5	9	4
265	R:R:C177	R:R:L168	1.59	No	No	5	9	4
266	R:R:I278	R:R:S281	1.55	No	No	0	5	5
267	R:R:H131	R:R:P132	1.53	No	No	0	6	8
268	R:R:I139	R:R:T143	1.52	No	No	0	7	3
269	R:R:I147	R:R:T143	1.52	No	No	0	4	3
270	R:R:I77	R:R:I78	1.47	No	No	0	5	4
271	R:R:L158	R:R:T159	1.47	No	No	0	4	6
272	R:R:L258	R:R:T263	1.47	No	No	0	3	3
273	R:R:D273	R:R:V272	1.46	No	No	0	4	4
274	R:R:I39	R:R:L36	1.43	No	No	0	5	4
275	R:R:I154	R:R:L158	1.43	No	No	0	4	4
276	R:R:L102	R:R:M106	1.41	No	No	0	4	5
277	R:R:C53	R:R:F54	1.4	No	No	0	2	4
278	R:R:L42	R:R:L43	1.38	No	No	0	6	4
279	R:R:E190	R:R:I182	1.37	Yes	No	0	4	2
280	R:R:H184	R:R:L258	1.29	No	No	0	3	3
281	R:R:K60	R:R:R63	1.24	No	Yes	0	7	7
282	R:R:L257	R:R:Y269	1.17	No	Yes	0	2	4
283	R:R:N175	R:R:W93	1.13	No	Yes	0	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.19167	6	3	0
2	R:R:F21	7.6875	4	1	3
3	R:R:F25	10.7625	4	1	5
4	R:R:V29	11.425	4	1	4
5	R:R:N45	5.3525	4	0	9
6	R:R:F52	5.005	4	4	7
7	R:R:R63	3.2775	4	4	7
8	R:R:L66	5.645	4	4	8
9	R:R:F74	5.9425	4	0	7
10	R:R:Y87	9.5375	4	1	5
11	R:R:W93	7.02	5	5	9
12	R:R:F105	7.0975	4	0	5
13	R:R:I115	7.3475	4	9	8
14	R:R:Y126	5.63857	7	2	8
15	R:R:W152	5.05	6	7	9
16	R:R:E190	7.6275	4	0	4
17	R:R:F193	12.11	4	0	5
18	R:R:F197	6.62	4	0	8
19	R:R:I226	3.456	5	0	7
20	R:R:F232	7.2225	4	0	7
21	R:R:V248	5.1175	4	0	8
22	R:R:R251	10.145	4	0	6
23	R:R:Y269	5.38167	6	0	4
24	R:R:R270	6.498	5	1	2
25	R:R:F276	5.77	4	0	4
26	R:R:F277	11.3725	4	1	5
27	R:R:L280	5.015	4	3	5
28	R:R:Y284	8.566	5	3	7
29	R:R:Y295	5.38167	6	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I178	34.3754	4.2	Yes	No	0	0	3
2	R:R:I178	R:R:S181	33.2639	10.84	No	No	0	3	5
3	R:R:S181	R:R:V20	32.0365	3.23	No	No	0	5	2
4	L:L:?1	R:R:R22	42.4714	5.96	Yes	No	0	0	5
5	R:R:F277	R:R:R22	63.6098	26.72	Yes	No	0	5	5
6	R:R:F277	R:R:L274	32.9072	3.65	Yes	No	1	5	3
7	R:R:L274	R:R:R270	32.5089	6.07	No	Yes	1	3	2
8	R:R:D273	R:R:R270	20.1149	3.57	No	Yes	0	4	2
9	R:R:D273	R:R:Y269	16.5393	5.75	No	Yes	0	4	4
10	R:R:D23	R:R:V20	28.2988	8.76	No	No	0	5	2
11	L:L:?1	R:R:Y284	53.8372	5.75	Yes	Yes	3	0	7
12	R:R:L280	R:R:Y284	52.1791	4.69	Yes	Yes	3	5	7
13	R:R:D23	R:R:V176	24.4778	4.38	No	No	0	5	1
14	R:R:F277	R:R:V29	24.5009	6.55	Yes	Yes	1	5	4
15	R:R:P31	R:R:V29	18.7995	7.07	No	Yes	0	6	4
16	R:R:L280	R:R:R22	34.4449	3.64	Yes	No	0	5	5
17	R:R:F276	R:R:L280	46.7649	7.31	Yes	Yes	0	4	5
18	R:R:F276	R:R:T279	12.8757	5.19	Yes	No	0	4	6
19	R:R:P246	R:R:T279	11.4816	5.25	No	No	0	9	6
20	R:R:F282	R:R:P246	10.0783	8.67	No	No	0	7	9
21	R:R:N110	R:R:Y284	100	4.65	No	Yes	0	8	7
22	R:R:L76	R:R:N110	99.4952	5.49	No	No	0	6	8
23	R:R:L76	R:R:S287	98.9903	4.5	No	No	0	6	8
24	R:R:D73	R:R:S287	97.0173	10.31	No	No	0	9	8
25	R:R:D73	R:R:N45	96.5356	10.77	No	Yes	0	9	9
26	R:R:F74	R:R:N45	19.082	2.42	Yes	Yes	0	7	9
27	R:R:N45	R:R:P291	88.1293	6.52	Yes	No	0	9	9
28	R:R:P291	R:R:Y295	87.5133	4.17	No	Yes	0	9	5
29	R:R:F52	R:R:Y295	23.1161	7.22	Yes	Yes	4	7	5
30	R:R:F52	R:R:L56	13.186	3.65	Yes	No	0	7	6
31	R:R:L66	R:R:Y295	60.7661	9.38	Yes	Yes	4	8	5
32	R:R:L66	R:R:R63	18.8597	3.64	Yes	Yes	4	8	7
33	R:R:L56	R:R:W59	11.1482	9.11	No	No	0	6	6
34	R:R:N141	R:R:W59	10.1524	3.39	No	No	0	3	6
35	L:L:?1	R:R:F180	32.1013	4.78	Yes	No	0	0	4
36	R:R:F180	R:R:H189	29.4475	7.92	No	No	0	4	5
37	R:R:H189	R:R:M192	27.127	10.51	No	No	0	5	5
38	R:R:M192	R:R:Q112	26.4184	8.16	No	No	0	5	7
39	R:R:Q112	R:R:T155	16.9561	4.25	No	No	0	7	7
40	R:R:T155	R:R:W152	16.2938	3.64	No	Yes	0	7	9
41	R:R:F117	R:R:W152	12.3894	12.03	No	Yes	7	7	9
42	R:R:F117	R:R:L151	12.6812	4.87	No	No	0	7	7
43	R:R:I147	R:R:L151	11.9772	2.85	No	No	0	4	7
44	R:R:I147	R:R:T143	11.6345	1.52	No	No	0	4	3
45	R:R:I139	R:R:T143	10.2635	1.52	No	No	0	7	3
46	R:R:L66	R:R:Y294	51.8503	4.69	Yes	No	0	8	9
47	R:R:R125	R:R:Y294	49.7383	11.32	No	No	0	9	9
48	R:R:I233	R:R:R125	47.6912	5.01	No	No	0	7	9
49	R:R:I233	R:R:S208	46.663	3.1	No	No	0	7	8
50	R:R:M234	R:R:S208	45.5282	3.07	No	No	0	5	8
51	R:R:I212	R:R:M234	44.3842	2.92	No	No	0	5	5
52	R:R:I212	R:R:I230	43.231	7.36	No	No	0	5	5
53	R:R:I226	R:R:I230	40.8967	2.94	Yes	No	0	7	5
54	R:R:I226	R:R:L215	29.9199	5.71	Yes	No	0	7	8
55	R:R:L215	R:R:V129	28.6508	4.47	No	No	0	8	8
56	R:R:I211	R:R:V129	27.3864	7.68	No	No	0	8	8
57	R:R:I211	R:R:Y126	26.1081	2.42	No	Yes	0	8	8
58	R:R:F52	R:R:R63	17.725	4.28	Yes	Yes	4	7	7
59	R:R:R63	R:R:S298	31.8605	3.95	Yes	No	0	7	8
60	R:R:C79	R:R:F107	20.3511	8.38	No	No	0	6	6
61	R:R:C79	R:R:M106	17.3081	6.48	No	No	0	6	5
62	R:R:V176	R:R:Y86	20.5734	2.52	No	No	0	1	5
63	R:R:W93	R:R:Y86	19.3507	11.58	Yes	No	0	9	5
64	R:R:F105	R:R:M106	14.946	3.73	Yes	No	0	5	5
65	R:R:F276	R:R:R251	36.3022	5.34	Yes	Yes	0	4	6
66	R:R:F193	R:R:R251	28.183	25.66	Yes	Yes	0	5	6
67	R:R:F193	R:R:R111	15.9742	9.62	Yes	No	0	5	7
68	R:R:E196	R:R:Q112	20.0361	11.47	No	No	0	6	7
69	R:R:E196	R:R:R111	15.1359	4.65	No	No	0	6	7
70	R:R:E196	R:R:I115	25.2374	10.93	No	Yes	0	6	8
71	R:R:I115	R:R:P200	15.3351	3.39	Yes	No	0	8	9
72	R:R:F193	R:R:V248	12.7461	6.55	Yes	Yes	0	5	8
73	R:R:P299	R:R:S298	27.0483	3.56	No	No	0	5	8
74	R:R:P299	R:R:R228	24.6121	5.76	No	No	0	5	7
75	R:R:R228	R:R:S297	22.338	2.64	No	No	0	7	6
76	R:R:F232	R:R:S297	19.8879	15.85	Yes	No	0	7	6
77	R:R:F232	R:R:V293	12.4821	2.62	Yes	No	0	7	7
78	R:R:F107	R:R:Y284	12.0004	16.5	No	Yes	3	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R22	5.96	3	Yes	No	0	5	0	1
L:L:?1	R:R:V83	11.7	3	Yes	No	0	6	0	1
L:L:?1	R:R:F107	10.76	3	Yes	No	0	6	0	1
L:L:?1	R:R:I178	4.2	3	Yes	No	0	3	0	1
L:L:?1	R:R:F180	4.78	3	Yes	No	0	4	0	1
L:L:?1	R:R:Y284	5.75	3	Yes	Yes	0	7	0	1
R:R:F277	R:R:R22	26.72	1	Yes	No	5	5	2	1
R:R:L280	R:R:R22	3.64	3	Yes	No	5	5	2	1
R:R:C79	R:R:F107	8.38	0	No	No	6	6	2	1
R:R:L80	R:R:V83	4.47	0	No	No	8	6	2	1
R:R:F107	R:R:Y284	16.5	3	No	Yes	6	7	1	1
R:R:N110	R:R:Y284	4.65	0	No	Yes	8	7	2	1
R:R:I178	R:R:S181	10.84	0	No	No	3	5	1	2
R:R:F180	R:R:S179	9.25	0	No	No	4	5	1	2
R:R:F180	R:R:H189	7.92	0	No	No	4	5	1	2
R:R:L280	R:R:T283	4.42	3	Yes	No	5	8	2	2
R:R:L280	R:R:Y284	4.69	3	Yes	Yes	5	7	2	1
R:R:T283	R:R:Y284	11.24	3	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JEF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	263
Number of Links	283
Number of Hubs	29
Number of Links mediated by Hubs	111
Number of Communities	9
Number of Nodes involved in Communities	41
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	44370
Length Of Smallest Path	3
Average Path Length	16.3977
Length of Longest Path	38
Minimum Path Strength	1.38
Average Path Strength	6.73802
Maximum Path Strength	17.64
Minimum Path Correlation	0.7
Average Path Correlation	0.923276
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	44.3607
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.5206
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	3HO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	3HO
Name	(3S)-3-hydroxyoctanoic acid
Synonyms
Identifier
Formula	C8 H16 O3
Molecular Weight	160.211
SMILES
PubChem	11367166
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49019
Sequence	>8JEF_nogp_Chain_R N C C V F R D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R R S D W K F G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N W T A A I I S C L L W G I T V G L T V H L L K K K L L I Q N G T A N V C I S F S I C H T F R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JEF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(3S)-3-hydroxyoctanoic acid	-	Gi1/β1/γ2	2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	8JEF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(3S)-3-hydroxyoctanoic acid	-		2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	8IHK	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	-	3.21	2023-08-30	10.1038/s41467-023-41650-7
	8IHJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.07	2023-08-30	10.1038/s41467-023-41650-7
	8IHJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.07	2023-08-30	10.1038/s41467-023-41650-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JEF_nogp.zip

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