psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C18	R:R:C183	7.28	No	No	0	8	1
2	R:R:C19	R:R:C266	7.28	No	No	0	3	6
3	R:R:V176	R:R:V20	4.81	Yes	No	0	1	2
4	R:R:F21	R:R:R270	7.48	No	No	0	3	2
5	R:R:D273	R:R:F21	5.97	No	No	0	4	3
6	R:R:R22	R:R:S91	7.91	No	No	0	5	4
7	R:R:D23	R:R:D24	5.32	No	No	0	5	4
8	R:R:D23	R:R:L274	5.43	No	No	0	5	3
9	R:R:D24	R:R:K28	9.68	No	No	0	4	3
10	R:R:F25	R:R:V29	6.55	No	No	0	5	4
11	R:R:I26	R:R:L30	4.28	No	Yes	0	4	6
12	R:R:I26	R:R:L274	12.85	No	No	0	4	3
13	R:R:L30	R:R:Y87	9.38	Yes	Yes	3	6	5
14	R:R:F277	R:R:L30	3.65	No	Yes	3	5	6
15	R:R:I278	R:R:L30	4.28	No	Yes	0	5	6
16	R:R:P31	R:R:P32	5.84	No	No	0	6	4
17	R:R:P31	R:R:Y87	5.56	No	Yes	0	6	5
18	R:R:S281	R:R:V33	3.23	No	No	0	5	6
19	R:R:L34	R:R:L80	6.92	No	No	0	8	8
20	R:R:L34	R:R:M84	7.07	No	No	0	8	7
21	R:R:G35	R:R:M84	3.49	No	No	0	5	7
22	R:R:E37	R:R:L36	7.95	No	No	0	7	4
23	R:R:F40	R:R:L36	6.09	No	No	0	5	4
24	R:R:E37	R:R:M285	4.06	No	Yes	0	7	5
25	R:R:F38	R:R:L42	9.74	No	No	0	6	6
26	R:R:F38	R:R:L80	4.87	No	No	0	6	8
27	R:R:F38	R:R:P81	5.78	No	No	0	6	9
28	R:R:F40	R:R:M288	6.22	No	No	0	5	6
29	R:R:G41	R:R:I77	3.53	No	No	0	8	5
30	R:R:G44	R:R:L43	3.42	No	No	0	7	4
31	R:R:G44	R:R:P291	4.06	No	No	0	7	9
32	R:R:D73	R:R:N45	5.39	Yes	No	0	9	9
33	R:R:N45	R:R:P291	9.77	No	No	0	9	9
34	R:R:F296	R:R:L47	3.65	No	No	0	7	5
35	R:R:A70	R:R:L49	3.15	No	No	0	8	7
36	R:R:F74	R:R:L49	6.09	No	No	0	7	7
37	R:R:F54	R:R:W50	7.02	No	No	0	4	4
38	R:R:H55	R:R:I51	11.93	No	No	0	5	7
39	R:R:F52	R:R:F67	5.36	No	Yes	0	7	6
40	R:R:F52	R:R:Y295	9.28	No	Yes	0	7	5
41	R:R:L56	R:R:W59	6.83	No	No	0	6	6
42	R:R:L56	R:R:R63	3.64	No	No	0	6	7
43	R:R:F67	R:R:W59	11.02	Yes	No	0	6	6
44	R:R:I139	R:R:S61	6.19	No	No	0	7	7
45	R:R:D124	R:R:S62	4.42	No	No	0	8	8
46	R:R:A144	R:R:I64	4.87	No	No	0	8	6
47	R:R:F65	R:R:V120	7.87	No	No	0	6	6
48	R:R:L66	R:R:V121	5.96	No	No	2	8	8
49	R:R:L66	R:R:Y294	3.52	No	Yes	2	8	9
50	R:R:L66	R:R:Y295	3.52	No	Yes	0	8	5
51	R:R:F67	R:R:N68	4.83	Yes	No	0	6	9
52	R:R:F67	R:R:V71	3.93	Yes	No	0	6	5
53	R:R:F117	R:R:N68	14.5	Yes	No	4	7	9
54	R:R:N68	R:R:S148	8.94	No	No	4	9	6
55	R:R:L118	R:R:L69	4.15	No	Yes	2	8	9
56	R:R:D290	R:R:L69	5.43	Yes	Yes	2	9	9
57	R:R:L69	R:R:Y294	5.86	Yes	Yes	2	9	9
58	R:R:L69	R:R:Y295	7.03	Yes	Yes	0	9	5
59	R:R:A70	R:R:Y295	4	No	Yes	0	8	5
60	R:R:D73	R:R:S114	5.89	Yes	No	0	9	9
61	R:R:D73	R:R:S287	10.31	Yes	No	0	9	8
62	R:R:D290	R:R:D73	6.65	Yes	Yes	0	9	9
63	R:R:L75	R:R:N110	12.36	No	No	0	6	8
64	R:R:F107	R:R:L76	3.65	Yes	No	0	6	6
65	R:R:L76	R:R:N110	6.87	No	No	0	6	8
66	R:R:I77	R:R:S287	4.64	No	No	0	5	8
67	R:R:C79	R:R:M106	3.24	No	No	0	6	5
68	R:R:L80	R:R:Y284	3.52	No	No	0	8	7
69	R:R:V83	R:R:Y87	3.79	No	Yes	0	6	5
70	L:L:?1	R:R:V83	5.22	Yes	No	0	0	6
71	R:R:S91	R:R:Y86	7.63	No	Yes	0	4	5
72	R:R:W93	R:R:Y86	8.68	Yes	Yes	1	9	5
73	R:R:C177	R:R:Y86	4.03	No	Yes	1	9	5
74	R:R:I178	R:R:Y86	3.63	No	Yes	0	3	5
75	R:R:F277	R:R:Y87	8.25	No	Yes	3	5	5
76	R:R:D92	R:R:R89	7.15	Yes	No	0	3	4
77	R:R:K94	R:R:R89	8.66	No	No	0	3	4
78	R:R:A174	R:R:D92	4.63	No	Yes	0	3	3
79	R:R:D92	R:R:N175	4.04	Yes	Yes	0	3	3
80	R:R:G96	R:R:W93	4.22	No	Yes	0	8	9
81	R:R:C100	R:R:W93	5.22	No	Yes	1	9	9
82	R:R:N175	R:R:W93	4.52	Yes	Yes	1	3	9
83	R:R:C177	R:R:W93	3.92	No	Yes	1	9	9
84	R:R:F95	R:R:K94	4.96	No	No	0	7	3
85	R:R:G96	R:R:P99	6.09	No	No	0	8	5
86	R:R:D97	R:R:I98	4.2	No	No	0	3	1
87	R:R:I98	R:R:P99	3.39	No	No	0	1	5
88	R:R:C100	R:R:L168	7.94	No	No	1	9	4
89	R:R:C100	R:R:C177	7.28	No	No	1	9	9
90	R:R:L104	R:R:S179	7.51	No	No	0	5	5
91	L:L:?1	R:R:L104	10.92	Yes	No	0	0	5
92	R:R:F105	R:R:T159	5.19	No	No	0	5	6
93	R:R:F105	R:R:L163	9.74	No	No	0	5	4
94	R:R:F107	R:R:Y284	8.25	Yes	No	0	6	7
95	L:L:?1	R:R:F107	19.22	Yes	Yes	0	0	6
96	R:R:M109	R:R:W152	3.49	No	No	0	5	9
97	R:R:M109	R:R:T155	4.52	No	No	0	5	7
98	R:R:E196	R:R:R111	3.49	No	No	0	6	7
99	R:R:R111	R:R:T283	5.17	No	No	0	7	8
100	L:L:?1	R:R:R111	10.65	Yes	No	0	0	7
101	R:R:L158	R:R:Q112	11.98	No	No	0	4	7
102	R:R:Q112	R:R:T159	4.25	No	No	0	7	6
103	R:R:M192	R:R:Q112	5.44	No	No	0	5	7
104	R:R:G113	R:R:T155	3.64	No	No	0	6	7
105	R:R:E196	R:R:I115	5.47	No	Yes	0	6	8
106	R:R:I115	R:R:P200	3.39	Yes	No	0	8	9
107	R:R:F240	R:R:I115	3.77	Yes	Yes	5	9	8
108	R:R:F244	R:R:I115	6.28	No	Yes	5	9	8
109	R:R:I116	R:R:L151	4.28	No	No	0	5	7
110	R:R:F117	R:R:S148	5.28	Yes	No	4	7	6
111	R:R:F117	R:R:L151	6.09	Yes	No	0	7	7
112	R:R:F117	R:R:W152	8.02	Yes	No	0	7	9
113	R:R:L118	R:R:Y294	10.55	No	Yes	2	8	9
114	R:R:P200	R:R:T119	3.5	No	No	0	9	7
115	R:R:I204	R:R:T119	6.08	No	No	0	8	7
116	R:R:R125	R:R:V121	6.54	No	No	0	9	8
117	R:R:V121	R:R:Y294	3.79	No	Yes	2	8	9
118	R:R:D124	R:R:R128	11.91	No	No	0	8	8
119	R:R:F127	R:R:Y126	5.16	Yes	Yes	0	5	8
120	R:R:V130	R:R:Y126	12.62	No	Yes	6	7	8
121	R:R:C207	R:R:Y126	9.41	No	Yes	0	6	8
122	R:R:R210	R:R:Y126	7.2	No	Yes	6	4	8
123	R:R:F127	R:R:H134	7.92	Yes	No	0	5	5
124	R:R:F127	R:R:L136	4.87	Yes	No	0	5	4
125	R:R:N137	R:R:R128	6.03	No	No	0	4	8
126	R:R:L215	R:R:V129	4.47	No	No	0	8	8
127	R:R:H131	R:R:V130	4.15	No	No	0	6	7
128	R:R:R210	R:R:V130	6.54	No	No	6	4	7
129	R:R:H133	R:R:P132	4.58	No	No	0	5	8
130	R:R:S140	R:R:T143	3.2	No	No	0	6	3
131	R:R:L158	R:R:W188	4.56	No	No	0	4	4
132	R:R:H161	R:R:L162	5.14	No	No	7	8	3
133	R:R:H161	R:R:W188	10.58	No	No	0	8	4
134	R:R:H161	R:R:H189	7.17	No	Yes	7	8	5
135	R:R:H189	R:R:L162	7.71	Yes	No	7	5	3
136	R:R:K165	R:R:L167	5.64	No	No	0	4	4
137	R:R:K165	R:R:R187	6.19	No	Yes	0	4	1
138	R:R:L168	R:R:Q170	5.32	No	No	1	4	2
139	R:R:L168	R:R:N175	8.24	No	Yes	1	4	3
140	R:R:N175	R:R:Q170	6.6	Yes	No	1	3	2
141	R:R:N171	R:R:V176	5.91	No	Yes	0	2	1
142	L:L:?1	R:R:I178	5.01	Yes	No	0	0	3
143	R:R:F180	R:R:S179	3.96	Yes	No	0	4	5
144	R:R:F180	R:R:H189	5.66	Yes	Yes	0	4	5
145	R:R:F180	R:R:F193	5.36	Yes	No	0	4	5
146	R:R:F180	R:R:F276	10.72	Yes	Yes	0	4	4
147	L:L:?1	R:R:F180	11.75	Yes	Yes	0	0	4
148	R:R:I182	R:R:I254	10.3	Yes	No	0	2	5
149	R:R:I182	R:R:L258	8.56	Yes	No	8	2	3
150	R:R:I182	R:R:Y269	14.51	Yes	Yes	8	2	4
151	R:R:D273	R:R:I182	5.6	No	Yes	0	4	2
152	R:R:H184	R:R:L258	9	No	No	0	3	3
153	R:R:H184	R:R:H259	3.58	No	No	0	3	2
154	R:R:H184	R:R:T263	4.11	No	No	0	3	3
155	R:R:H189	R:R:R187	13.54	Yes	Yes	0	5	1
156	R:R:E190	R:R:R187	22.1	No	Yes	0	4	1
157	R:R:H189	R:R:M192	5.25	Yes	No	0	5	5
158	R:R:E190	R:R:R251	11.63	No	No	0	4	6
159	R:R:E196	R:R:F193	7	No	No	0	6	5
160	R:R:F193	R:R:S247	5.28	No	No	0	5	6
161	R:R:F197	R:R:F198	5.36	Yes	No	0	8	4
162	R:R:F197	R:R:L201	3.65	Yes	No	0	8	6
163	R:R:F197	R:R:F240	3.22	Yes	Yes	0	8	9
164	R:R:F197	R:R:L245	6.09	Yes	No	0	8	5
165	R:R:F197	R:R:V248	7.87	Yes	No	0	8	8
166	R:R:L199	R:R:P200	3.28	No	No	0	5	9
167	R:R:F240	R:R:I204	3.77	Yes	No	0	9	8
168	R:R:I233	R:R:S208	4.64	No	No	0	7	8
169	R:R:I211	R:R:I233	8.83	No	No	0	8	7
170	R:R:I212	R:R:I233	5.89	No	No	0	5	7
171	R:R:I212	R:R:M234	10.2	No	No	0	5	5
172	R:R:Q217	R:R:W213	3.29	No	No	0	5	4
173	R:R:D221	R:R:R216	7.15	No	No	0	3	4
174	R:R:M220	R:R:R218	4.96	No	No	0	3	6
175	R:R:D221	R:R:R222	10.72	No	No	0	3	4
176	R:R:A224	R:R:I226	3.25	No	No	0	4	7
177	R:R:F232	R:R:R228	10.69	No	No	0	7	7
178	R:R:P299	R:R:R228	4.32	No	No	0	5	7
179	R:R:F232	R:R:S297	13.21	No	No	0	7	6
180	R:R:V235	R:R:V293	4.81	No	Yes	0	5	7
181	R:R:V236	R:R:Y294	12.62	No	Yes	0	7	9
182	R:R:F240	R:R:F244	6.43	Yes	No	5	9	9
183	R:R:C243	R:R:M285	3.24	Yes	Yes	0	8	5
184	R:R:C243	R:R:N286	3.15	Yes	No	0	8	9
185	R:R:F244	R:R:N286	9.67	No	No	0	9	9
186	R:R:L245	R:R:P246	3.28	No	No	0	5	9
187	R:R:F282	R:R:P246	5.78	No	No	0	7	9
188	R:R:S247	R:R:T279	3.2	No	No	0	6	6
189	R:R:F276	R:R:V250	3.93	Yes	No	0	4	4
190	R:R:T279	R:R:V250	6.35	No	No	0	6	4
191	R:R:F276	R:R:R251	6.41	Yes	No	0	4	6
192	R:R:I254	R:R:V272	6.14	No	No	0	5	4
193	R:R:L257	R:R:Y269	7.03	No	Yes	0	2	4
194	R:R:L258	R:R:Y269	10.55	No	Yes	8	3	4
195	R:R:H259	R:R:T260	4.11	No	No	0	2	1
196	R:R:S261	R:R:T260	3.2	No	No	0	4	1
197	R:R:G262	R:R:T263	5.46	No	No	0	3	3
198	R:R:E267	R:R:N265	3.94	No	No	0	1	4
199	R:R:C266	R:R:Y269	5.38	No	Yes	0	6	4
200	R:R:E267	R:R:R270	15.12	No	No	0	1	2
201	R:R:I278	R:R:L274	4.28	No	No	0	5	3
202	L:L:?1	R:R:F277	6.41	Yes	No	0	0	5
203	R:R:L280	R:R:Y284	3.52	No	No	0	5	7
204	L:L:?1	R:R:L280	9.71	Yes	No	0	0	5
205	R:R:M285	R:R:M288	7.22	Yes	No	0	5	6
206	R:R:L289	R:R:M285	4.24	No	Yes	0	7	5
207	R:R:D290	R:R:N286	9.42	Yes	No	0	9	9
208	R:R:D290	R:R:Y294	4.6	Yes	Yes	2	9	9
209	R:R:P299	R:R:S298	3.56	No	No	0	5	8
210	R:R:I169	R:R:V176	3.07	No	Yes	0	1	1
211	R:R:I252	R:R:V248	3.07	No	No	0	6	8
212	R:R:M109	R:R:V156	3.04	No	No	0	5	4
213	R:R:I203	R:R:T119	3.04	No	No	0	6	7
214	R:R:L245	R:R:V241	2.98	No	No	0	5	4
215	R:R:I212	R:R:I230	2.94	No	Yes	0	5	5
216	R:R:I226	R:R:I230	2.94	No	Yes	0	7	5
217	R:R:D85	R:R:V88	2.92	No	No	0	4	3
218	R:R:F296	R:R:P291	2.89	No	No	0	7	9
219	R:R:I139	R:R:L136	2.85	No	No	0	7	4
220	R:R:I147	R:R:L151	2.85	No	No	0	4	7
221	R:R:I252	R:R:L194	2.85	No	No	0	6	4
222	R:R:I230	R:R:L215	2.85	Yes	No	0	5	8
223	R:R:L215	R:R:M220	2.83	No	No	0	8	3
224	R:R:Q264	R:R:T263	2.83	No	No	0	1	3
225	R:R:C53	R:R:F54	2.79	No	No	0	2	4
226	R:R:C207	R:R:F206	2.79	No	No	0	6	3
227	R:R:A144	R:R:F65	2.77	No	No	0	8	6
228	R:R:D85	R:R:K94	2.77	No	No	0	4	3
229	R:R:A48	R:R:Y295	2.67	No	Yes	0	8	5
230	R:R:R63	R:R:S298	2.64	No	No	0	7	8
231	R:R:F65	R:R:S148	2.64	No	No	0	6	6
232	R:R:R218	R:R:S214	2.64	No	No	0	6	5
233	R:R:F105	R:R:V160	2.62	No	No	0	5	4
234	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
235	L:L:?1	R:R:V103	2.61	Yes	No	0	0	5
236	R:R:A72	R:R:W152	2.59	No	No	0	8	9
237	R:R:F232	R:R:T231	2.59	No	No	0	7	6
238	R:R:H253	R:R:L257	2.57	No	No	0	5	2
239	R:R:V176	R:R:Y86	2.52	Yes	Yes	0	1	5
240	R:R:V268	R:R:Y269	2.52	No	Yes	0	1	4
241	R:R:F25	R:R:I278	2.51	No	No	0	5	5
242	R:R:K166	R:R:R101	2.48	No	No	0	5	7
243	R:R:T260	R:R:W256	2.43	No	No	0	1	4
244	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	8
245	R:R:F54	R:R:H55	2.26	No	No	0	4	5
246	R:R:H223	R:R:R222	2.26	No	No	0	3	4
247	R:R:F255	R:R:H259	2.26	No	No	0	5	2
248	R:R:F82	R:R:W93	2	No	Yes	0	6	9
249	R:R:G157	R:R:V156	1.84	No	No	0	4	4
250	R:R:G172	R:R:T173	1.82	No	No	0	3	5
251	R:R:A144	R:R:S61	1.71	No	No	0	8	7
252	R:R:C243	R:R:V239	1.71	Yes	No	0	8	7
253	R:R:A275	R:R:V250	1.7	No	No	0	5	4
254	R:R:A108	R:R:T159	1.68	No	No	0	5	6
255	R:R:A174	R:R:T173	1.68	No	No	0	3	5
256	R:R:C79	R:R:I78	1.64	No	No	0	6	4
257	R:R:C243	R:R:I242	1.64	Yes	No	0	8	5
258	R:R:S181	R:R:V20	1.62	No	No	0	5	2
259	R:R:A122	R:R:I204	1.62	No	No	0	9	8
260	R:R:A224	R:R:K227	1.61	No	No	0	4	5
261	R:R:V236	R:R:V293	1.6	No	Yes	0	7	7
262	R:R:V239	R:R:V293	1.6	No	Yes	0	7	7
263	R:R:V292	R:R:V293	1.6	No	Yes	0	6	7
264	R:R:A237	R:R:L205	1.58	No	No	0	7	4
265	R:R:K60	R:R:S58	1.53	No	No	0	7	6
266	R:R:H131	R:R:P132	1.53	No	No	0	6	8
267	R:R:I139	R:R:T143	1.52	No	No	0	7	3
268	R:R:F74	R:R:G46	1.51	No	No	0	7	1
269	R:R:L30	R:R:S281	1.5	Yes	No	0	6	5
270	R:R:I238	R:R:I242	1.47	No	No	0	4	5
271	R:R:I39	R:R:L43	1.43	No	No	0	5	4
272	R:R:I64	R:R:N141	1.42	No	No	0	6	3
273	R:R:C79	R:R:F107	1.4	No	Yes	0	6	6
274	R:R:M106	R:R:N110	1.4	No	No	0	5	8
275	R:R:D221	R:R:I230	1.4	No	Yes	0	3	5
276	R:R:L201	R:R:L205	1.38	No	No	0	6	4
277	R:R:R128	R:R:V129	1.31	No	No	0	8	8
278	R:R:R187	R:R:T185	1.29	Yes	No	0	1	4
279	R:R:F276	R:R:I254	1.26	Yes	No	0	4	5
280	R:R:K60	R:R:R63	1.24	No	No	0	7	7
281	R:R:S140	R:R:W142	1.24	No	No	0	6	4
282	R:R:L163	R:R:R101	1.21	No	No	0	4	7
283	R:R:L167	R:R:R101	1.21	No	No	0	4	7
284	R:R:D92	R:R:R90	1.19	Yes	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L30	4.618	5	3	6
2	R:R:F67	6.285	4	0	6
3	R:R:L69	5.6175	4	2	9
4	R:R:D73	7.06	4	0	9
5	R:R:Y86	5.298	5	1	5
6	R:R:Y87	6.745	4	3	5
7	R:R:D92	4.2525	4	0	3
8	R:R:W93	4.76	6	1	9
9	R:R:F107	8.13	4	0	6
10	R:R:I115	4.7275	4	5	8
11	R:R:F117	8.4725	4	4	7
12	R:R:Y126	7.362	5	6	8
13	R:R:F127	5.1425	4	0	5
14	R:R:N175	5.85	4	1	3
15	R:R:V176	4.0775	4	0	1
16	R:R:F180	7.49	5	0	4
17	R:R:I182	9.7425	4	8	2
18	R:R:R187	10.78	4	0	1
19	R:R:H189	7.866	5	7	5
20	R:R:F197	5.238	5	0	8
21	R:R:I230	2.5325	4	0	5
22	R:R:F240	4.2975	4	5	9
23	R:R:C243	2.435	4	0	8
24	R:R:Y269	7.998	5	8	4
25	R:R:F276	5.58	4	0	4
26	R:R:M285	4.69	4	0	5
27	R:R:D290	6.525	4	2	9
28	R:R:V293	2.4025	4	0	7
29	R:R:Y294	6.82333	6	2	9
30	R:R:Y295	5.3	5	0	5
31	L:L:?1	9.05556	9	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I182	R:R:I254	29.849	10.3	Yes	No	0	2	5
2	R:R:F276	R:R:I254	32.2225	1.26	Yes	No	0	4	5
3	R:R:F180	R:R:F276	37.1709	10.72	Yes	Yes	0	4	4
4	L:L:?1	R:R:F180	24.4185	11.75	Yes	Yes	0	0	4
5	L:L:?1	R:R:I178	42.0397	5.01	Yes	No	0	0	3
6	R:R:I178	R:R:Y86	41.0755	3.63	No	Yes	0	3	5
7	L:L:?1	R:R:F277	24.9272	6.41	Yes	No	0	0	5
8	R:R:F277	R:R:L30	19.9152	3.65	No	Yes	3	5	6
9	L:L:?1	R:R:F107	19.9364	19.22	Yes	Yes	0	0	6
10	R:R:F107	R:R:Y284	11.0093	8.25	Yes	No	0	6	7
11	R:R:L80	R:R:Y284	19.0199	3.52	No	No	0	8	7
12	L:L:?1	R:R:L280	11.9629	9.71	Yes	No	0	0	5
13	R:R:L280	R:R:Y284	10.755	3.52	No	No	0	5	7
14	R:R:F180	R:R:F193	38.4212	5.36	Yes	No	0	4	5
15	R:R:E196	R:R:F193	40.1166	7	No	No	0	6	5
16	R:R:E196	R:R:I115	100	5.47	No	Yes	0	6	8
17	R:R:F244	R:R:I115	87.8411	6.28	No	Yes	5	9	8
18	R:R:F244	R:R:N286	97.6954	9.67	No	No	0	9	9
19	R:R:C243	R:R:N286	16.604	3.15	Yes	No	0	8	9
20	R:R:D290	R:R:N286	91.0093	9.42	Yes	No	0	9	9
21	R:R:D290	R:R:D73	16.906	6.65	Yes	Yes	0	9	9
22	R:R:D73	R:R:N45	10.045	5.39	Yes	No	0	9	9
23	R:R:L69	R:R:Y295	80.2649	7.03	Yes	Yes	0	9	5
24	R:R:D290	R:R:L69	79.0623	5.43	Yes	Yes	2	9	9
25	R:R:F52	R:R:Y295	79.4914	9.28	No	Yes	0	7	5
26	R:R:F52	R:R:F67	78.8344	5.36	No	Yes	0	7	6
27	R:R:F67	R:R:W59	15.6026	11.02	Yes	No	0	6	6
28	R:R:L56	R:R:W59	14.3311	6.83	No	No	0	6	6
29	R:R:L56	R:R:R63	12.943	3.64	No	No	0	6	7
30	R:R:F67	R:R:N68	68.2331	4.83	Yes	No	0	6	9
31	R:R:N68	R:R:S148	54.0397	8.94	No	No	4	9	6
32	R:R:F65	R:R:S148	55.6291	2.64	No	No	0	6	6
33	R:R:A144	R:R:F65	53.5735	2.77	No	No	0	8	6
34	R:R:A144	R:R:S61	50.347	1.71	No	No	0	8	7
35	R:R:I139	R:R:S61	49.2344	6.19	No	No	0	7	7
36	R:R:I139	R:R:L136	44.7417	2.85	No	No	0	7	4
37	R:R:F127	R:R:L136	43.5921	4.87	Yes	No	0	5	4
38	R:R:F127	R:R:Y126	40.2225	5.16	Yes	Yes	0	5	8
39	R:R:I211	R:R:Y126	30.3894	2.42	No	Yes	0	8	8
40	R:R:I211	R:R:I233	29.1073	8.83	No	No	0	8	7
41	R:R:I212	R:R:I233	26.649	5.89	No	No	0	5	7
42	R:R:I212	R:R:I230	24.0053	2.94	No	Yes	0	5	5
43	R:R:I230	R:R:L215	13.0649	2.85	Yes	No	0	5	8
44	R:R:F117	R:R:N68	13.2821	14.5	Yes	No	4	7	9
45	R:R:W93	R:R:Y86	28.0318	8.68	Yes	Yes	1	9	5
46	R:R:N175	R:R:W93	17.8861	4.52	Yes	Yes	1	3	9
47	R:R:D92	R:R:N175	13.9815	4.04	Yes	Yes	0	3	3
48	R:R:F180	R:R:H189	27.4861	5.66	Yes	Yes	0	4	5
49	R:R:H189	R:R:M192	11.0781	5.25	Yes	No	0	5	5
50	R:R:H189	R:R:R187	10.8079	13.54	Yes	Yes	0	5	1
51	R:R:F117	R:R:W152	10.2675	8.02	Yes	No	0	7	9
52	L:L:?1	R:R:R111	59.857	10.65	Yes	No	0	0	7
53	R:R:F240	R:R:I115	11.5762	3.77	Yes	Yes	5	9	8
54	R:R:H184	R:R:L258	13.0119	9	No	No	0	3	3
55	R:R:F197	R:R:F240	16.7788	3.22	Yes	Yes	0	8	9
56	R:R:E196	R:R:R111	59.9894	3.49	No	No	0	6	7
57	R:R:I182	R:R:L258	14.0874	8.56	Yes	No	8	2	3
58	R:R:F240	R:R:F244	10.1298	6.43	Yes	No	5	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L30	R:R:Y87	9.38	3	Yes	Yes	6	5	2	2
R:R:F277	R:R:L30	3.65	3	No	Yes	5	6	1	2
R:R:F107	R:R:L76	3.65	0	Yes	No	6	6	1	2
R:R:V83	R:R:Y87	3.79	0	No	Yes	6	5	1	2
L:L:?1	R:R:V83	5.22	0	Yes	No	0	6	0	1
R:R:I178	R:R:Y86	3.63	0	No	Yes	3	5	1	2
R:R:F277	R:R:Y87	8.25	3	No	Yes	5	5	1	2
R:R:L104	R:R:S179	7.51	0	No	No	5	5	1	2
L:L:?1	R:R:L104	10.92	0	Yes	No	0	5	0	1
R:R:F107	R:R:Y284	8.25	0	Yes	No	6	7	1	2
L:L:?1	R:R:F107	19.22	0	Yes	Yes	0	6	0	1
R:R:E196	R:R:R111	3.49	0	No	No	6	7	2	1
R:R:R111	R:R:T283	5.17	0	No	No	7	8	1	2
L:L:?1	R:R:R111	10.65	0	Yes	No	0	7	0	1
L:L:?1	R:R:I178	5.01	0	Yes	No	0	3	0	1
R:R:F180	R:R:S179	3.96	0	Yes	No	4	5	1	2
R:R:F180	R:R:H189	5.66	0	Yes	Yes	4	5	1	2
R:R:F180	R:R:F193	5.36	0	Yes	No	4	5	1	2
R:R:F180	R:R:F276	10.72	0	Yes	Yes	4	4	1	2
L:L:?1	R:R:F180	11.75	0	Yes	Yes	0	4	0	1
R:R:E196	R:R:F193	7	0	No	No	6	5	2	2
L:L:?1	R:R:F277	6.41	0	Yes	No	0	5	0	1
R:R:L280	R:R:Y284	3.52	0	No	No	5	7	1	2
L:L:?1	R:R:L280	9.71	0	Yes	No	0	5	0	1
L:L:?1	R:R:V103	2.61	0	Yes	No	0	5	0	1
R:R:C79	R:R:F107	1.4	0	No	Yes	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IHJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	261
Number of Links	284
Number of Hubs	31
Number of Links mediated by Hubs	121
Number of Communities	8
Number of Nodes involved in Communities	31
Number of Links involved in Communities	36

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	37679
Length Of Smallest Path	3
Average Path Length	14.806
Length of Longest Path	38
Minimum Path Strength	1.21
Average Path Strength	6.16529
Maximum Path Strength	17.82
Minimum Path Correlation	0.7
Average Path Correlation	0.920453
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.7299
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.866
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • cellular anatomical structure • periplasmic space • cell junction • cell periphery • plasma membrane • membrane • D2 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • myelin sheath • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor outer segment • photoreceptor cell cilium • synapse • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P9X
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P9X
Name	(5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid
Synonyms	Acifran
Identifier
Formula	C12 H10 O4
Molecular Weight	218.205
SMILES
PubChem	76969700
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	27
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49019
Sequence	>8IHJ_nogp_Chain_R N C C V F R D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R R S D W K F G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N W T A A I I S C L L W G I T V G L T V H L L K K K L L I Q N G T A N V C I S F S I C H T F R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JEF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(3S)-3-hydroxyoctanoic acid	-	Gi1/β1/γ2	2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	8JEF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(3S)-3-hydroxyoctanoic acid	-		2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	8IHK	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	-	3.21	2023-08-30	10.1038/s41467-023-41650-7
	8IHJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.07	2023-08-30	10.1038/s41467-023-41650-7
	8IHJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.07	2023-08-30	10.1038/s41467-023-41650-7

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