psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F159	R:R:I447	3.77	No	Yes	6	4	2
2	R:R:F159	R:R:Q464	4.68	No	No	6	4	1
3	R:R:C161	R:R:P162	3.77	No	No	0	9	6
4	R:R:C161	R:R:I178	3.27	No	No	7	9	5
5	R:R:C161	R:R:C181	7.28	No	No	7	9	9
6	R:R:P162	R:R:Y457	6.95	No	No	0	6	4
7	R:R:H164	R:R:L165	3.86	Yes	No	0	5	7
8	R:R:E268	R:R:H164	7.39	No	Yes	0	1	5
9	R:R:H164	R:R:L269	6.43	Yes	No	0	5	3
10	R:R:H164	R:R:Y457	11.98	Yes	No	0	5	4
11	R:R:L165	R:R:P184	8.21	No	No	0	7	6
12	R:R:K166	R:R:Q180	13.56	No	Yes	0	5	5
13	R:R:Q180	R:R:T167	8.5	Yes	No	0	5	5
14	R:R:G170	R:R:Q278	3.29	No	No	0	4	5
15	R:R:Q171	R:R:Q180	6.4	No	Yes	0	4	5
16	R:R:D363	R:R:Y173	17.24	No	No	0	7	5
17	R:R:D179	R:R:K174	9.68	No	No	0	3	3
18	R:R:F175	R:R:L176	6.09	Yes	No	0	6	4
19	R:R:C181	R:R:F175	5.59	No	Yes	0	9	6
20	R:R:F175	R:R:P183	10.11	Yes	Yes	0	6	5
21	R:R:E446	R:R:F175	10.49	No	Yes	0	5	6
22	R:R:C181	R:R:I178	3.27	No	No	7	9	5
23	R:R:D179	R:R:Q180	6.53	No	Yes	0	3	5
24	R:R:P183	R:R:V273	3.53	Yes	Yes	0	5	6
25	R:R:P183	R:R:Y362	5.56	Yes	No	0	5	5
26	R:R:C185	R:R:C260	7.28	No	No	0	9	9
27	R:R:N187	R:R:Y189	10.47	No	No	0	5	5
28	R:R:N187	R:R:N352	6.81	No	No	0	5	7
29	R:R:N187	R:R:Y362	4.65	No	No	0	5	5
30	R:R:M188	R:R:W449	6.98	No	No	8	6	5
31	R:R:H453	R:R:M188	9.19	Yes	No	8	5	6
32	R:R:F190	R:R:Y189	4.13	Yes	No	0	7	5
33	R:R:W449	R:R:Y189	3.86	No	No	0	5	5
34	R:R:E194	R:R:F190	5.83	No	Yes	0	7	7
35	R:R:F190	R:R:L473	4.87	Yes	No	0	7	5
36	R:R:F190	R:R:F476	6.43	Yes	No	0	7	6
37	R:R:D193	R:R:S192	7.36	No	No	0	4	3
38	R:R:D193	R:R:E194	5.2	No	No	0	4	7
39	R:R:G255	R:R:K199	3.49	No	No	0	7	7
40	R:R:F201	R:R:V205	6.55	No	No	0	8	6
41	R:R:F201	R:R:M477	6.22	No	No	0	8	7
42	R:R:I202	R:R:Y480	3.63	No	Yes	0	7	7
43	R:R:G203	R:R:S206	3.71	No	No	0	5	7
44	R:R:F252	R:R:G203	9.03	No	No	0	5	5
45	R:R:L481	R:R:V205	4.47	No	No	0	5	6
46	R:R:F249	R:R:S206	3.96	No	No	0	6	7
47	R:R:F249	R:R:I207	3.77	No	No	0	6	4
48	R:R:C209	R:R:L484	7.94	No	No	0	8	8
49	R:R:C209	R:R:I488	3.27	No	Yes	0	8	7
50	R:R:L210	R:R:L214	5.54	No	No	0	5	5
51	R:R:L210	R:R:L246	4.15	No	No	0	5	4
52	R:R:S242	R:R:T213	4.8	No	No	0	5	8
53	R:R:L214	R:R:S242	9.01	No	No	0	5	5
54	R:R:F215	R:R:T219	6.49	No	No	0	7	9
55	R:R:F220	R:R:T216	3.89	Yes	No	0	8	9
56	R:R:F217	R:R:L221	4.87	No	No	0	6	5
57	R:R:F220	R:R:F227	4.29	Yes	No	0	8	8
58	R:R:F220	R:R:I235	8.79	Yes	No	0	8	7
59	R:R:F220	R:R:V494	7.87	Yes	No	0	8	6
60	R:R:C317	R:R:R228	8.36	No	No	9	6	6
61	R:R:E318	R:R:R228	4.65	No	No	9	9	6
62	R:R:R232	R:R:Y229	10.29	No	Yes	0	8	9
63	R:R:I320	R:R:Y229	4.84	Yes	Yes	4	8	9
64	R:R:E321	R:R:Y229	8.98	No	Yes	4	6	9
65	R:R:A324	R:R:Y229	6.67	No	Yes	4	7	9
66	R:R:F327	R:R:Y229	6.19	No	Yes	0	9	9
67	R:R:P230	R:R:T306	3.5	No	No	0	9	7
68	R:R:C317	R:R:P230	3.77	No	No	0	6	9
69	R:R:E231	R:R:F413	3.5	No	No	0	9	8
70	R:R:E231	R:R:R416	11.63	No	No	1	9	9
71	R:R:E231	R:R:W493	7.63	No	Yes	1	9	9
72	R:R:R232	R:R:Y236	5.14	No	Yes	0	8	6
73	R:R:I302	R:R:P233	3.39	No	No	0	6	8
74	R:R:L303	R:R:P233	8.21	No	No	0	9	8
75	R:R:F420	R:R:I234	7.54	Yes	No	1	9	8
76	R:R:I234	R:R:W493	10.57	No	Yes	1	8	9
77	R:R:I235	R:R:Y236	3.63	No	Yes	0	7	6
78	R:R:W299	R:R:Y236	8.68	Yes	Yes	5	9	6
79	R:R:H328	R:R:Y236	5.44	No	Yes	5	9	6
80	R:R:Y237	R:R:Y241	11.91	Yes	Yes	1	8	8
81	R:R:F420	R:R:Y237	13.41	Yes	Yes	1	9	8
82	R:R:Y237	R:R:Y424	6.95	Yes	Yes	1	8	7
83	R:R:S489	R:R:Y237	5.09	No	Yes	1	7	8
84	R:R:C240	R:R:F292	5.59	No	Yes	0	9	9
85	R:R:C240	R:R:G296	3.92	No	No	0	9	7
86	R:R:G296	R:R:Y241	4.35	No	Yes	0	7	8
87	R:R:Y241	R:R:Y424	4.96	Yes	Yes	1	8	7
88	R:R:V486	R:R:Y241	5.05	No	Yes	1	7	8
89	R:R:G487	R:R:Y241	4.35	No	Yes	0	9	8
90	R:R:F292	R:R:I243	13.82	Yes	No	0	9	5
91	R:R:T293	R:R:V244	6.35	No	No	0	6	7
92	R:R:L285	R:R:M247	4.24	No	No	0	7	7
93	R:R:L288	R:R:M247	4.24	No	No	0	5	7
94	R:R:L289	R:R:M247	4.24	Yes	No	0	6	7
95	R:R:L289	R:R:Y248	5.86	Yes	Yes	3	6	8
96	R:R:S354	R:R:Y248	5.09	No	Yes	3	8	8
97	R:R:V356	R:R:Y248	3.79	No	Yes	3	8	8
98	R:R:Y248	R:R:Y480	3.97	Yes	Yes	3	8	7
99	R:R:T483	R:R:Y248	4.99	No	Yes	0	5	8
100	R:R:L484	R:R:Y248	7.03	No	Yes	0	8	8
101	R:R:F249	R:R:L253	6.09	No	No	0	6	3
102	R:R:L254	R:R:S257	4.5	No	No	0	4	3
103	R:R:S257	R:R:T258	6.4	No	No	0	3	6
104	R:R:A281	R:R:T258	5.03	No	No	0	5	6
105	R:R:N261	R:R:V274	5.91	No	No	0	5	6
106	R:R:D271	R:R:K262	8.3	No	No	0	4	3
107	R:R:G270	R:R:L267	5.13	No	No	0	1	1
108	R:R:D271	R:R:L269	10.86	No	No	0	4	3
109	R:R:N352	R:R:V273	4.43	No	Yes	0	7	6
110	R:R:C282	R:R:V274	3.42	No	No	0	9	6
111	R:R:G276	R:R:N346	5.09	No	No	0	7	5
112	R:R:S277	R:R:T283	6.4	No	No	0	6	7
113	R:R:C282	R:R:C357	7.28	No	No	0	9	9
114	R:R:L343	R:R:T283	4.42	No	No	0	8	7
115	R:R:L285	R:R:V356	4.47	No	No	0	7	8
116	R:R:F286	R:R:Y290	8.25	Yes	Yes	10	9	9
117	R:R:F286	R:R:L342	7.31	Yes	No	0	9	6
118	R:R:F286	R:R:V348	5.24	Yes	No	0	9	8
119	R:R:F286	R:R:V359	3.93	Yes	No	10	9	9
120	R:R:M287	R:R:T339	4.52	No	No	0	6	8
121	R:R:F292	R:R:L288	3.65	Yes	No	0	9	5
122	R:R:L289	R:R:V356	4.47	Yes	No	3	6	8
123	R:R:F358	R:R:L289	3.65	Yes	Yes	0	7	6
124	R:R:M294	R:R:Y290	9.58	Yes	Yes	0	8	9
125	R:R:L338	R:R:Y290	3.52	No	Yes	0	7	9
126	R:R:F358	R:R:Y290	6.19	Yes	Yes	0	7	9
127	R:R:V359	R:R:Y290	3.79	No	Yes	10	9	9
128	R:R:F291	R:R:F292	10.72	Yes	Yes	0	8	9
129	R:R:F291	R:R:W332	4.01	Yes	No	0	8	9
130	R:R:F291	R:R:P335	5.78	Yes	Yes	0	8	9
131	R:R:F291	R:R:T339	5.19	Yes	No	0	8	8
132	R:R:M294	R:R:P335	3.35	Yes	Yes	0	8	9
133	R:R:M294	R:R:P374	3.35	Yes	No	0	8	9
134	R:R:L375	R:R:M294	4.24	No	Yes	0	7	8
135	R:R:A295	R:R:P335	3.74	No	Yes	0	9	9
136	R:R:C378	R:R:T297	3.38	No	No	0	6	5
137	R:R:T297	R:R:Y424	3.75	No	Yes	0	5	7
138	R:R:P335	R:R:V298	3.53	Yes	No	0	9	5
139	R:R:H328	R:R:W299	9.52	No	Yes	5	9	9
140	R:R:A331	R:R:W299	10.37	No	Yes	0	9	9
141	R:R:W299	R:R:W332	18.74	Yes	No	5	9	9
142	R:R:T304	R:R:W300	6.06	No	Yes	0	7	9
143	R:R:F420	R:R:W300	5.01	Yes	Yes	0	9	9
144	R:R:S421	R:R:W300	3.71	Yes	Yes	0	7	9
145	R:R:W300	R:R:Y424	11.58	Yes	Yes	0	9	7
146	R:R:L425	R:R:W300	4.56	No	Yes	0	5	9
147	R:R:C378	R:R:V301	3.42	No	No	0	6	8
148	R:R:F327	R:R:I302	8.79	No	No	0	9	6
149	R:R:G382	R:R:T304	5.46	No	No	0	8	7
150	R:R:L385	R:R:T304	4.42	No	No	0	8	7
151	R:R:A311	R:R:W307	7.78	No	Yes	0	8	9
152	R:R:G389	R:R:W307	5.63	No	Yes	0	8	9
153	R:R:F413	R:R:W307	10.02	No	Yes	0	8	9
154	R:R:M414	R:R:W307	3.49	No	Yes	0	8	9
155	R:R:F308	R:R:L385	6.09	No	No	0	7	8
156	R:R:A388	R:R:F308	4.16	No	No	0	6	7
157	R:R:L309	R:R:W315	7.97	No	Yes	4	8	8
158	R:R:I320	R:R:L309	5.71	Yes	No	4	8	8
159	R:R:G312	R:R:S392	3.71	No	No	0	6	7
160	R:R:R313	R:R:W315	9	No	Yes	0	7	8
161	R:R:I320	R:R:W315	3.52	Yes	Yes	4	8	8
162	R:R:K323	R:R:W315	5.8	No	Yes	0	6	8
163	R:R:C317	R:R:E318	7.6	No	No	9	6	9
164	R:R:A324	R:R:E321	4.53	No	No	4	7	6
165	R:R:K323	R:R:W326	3.48	No	No	0	6	7
166	R:R:V325	R:R:W326	3.68	No	No	0	6	7
167	R:R:H328	R:R:W332	8.46	No	No	5	9	9
168	R:R:T334	R:R:V330	4.76	No	No	0	5	5
169	R:R:P335	R:R:T334	3.5	Yes	No	0	9	5
170	R:R:F337	R:R:M341	6.22	No	No	0	5	4
171	R:R:F370	R:R:L342	7.31	No	No	0	8	6
172	R:R:K347	R:R:M345	4.32	Yes	No	0	6	5
173	R:R:D363	R:R:K347	5.53	No	Yes	0	7	6
174	R:R:D365	R:R:K347	8.3	No	Yes	0	1	6
175	R:R:D351	R:R:I353	4.2	No	No	3	9	7
176	R:R:D351	R:R:L361	5.43	No	No	0	9	7
177	R:R:D351	R:R:Y480	8.05	No	Yes	3	9	7
178	R:R:I353	R:R:Y480	10.88	No	Yes	3	7	7
179	R:R:S354	R:R:Y480	7.63	No	Yes	3	8	7
180	R:R:F358	R:R:L361	3.65	Yes	No	0	7	7
181	R:R:L364	R:R:Q439	7.99	No	Yes	2	3	5
182	R:R:L364	R:R:R442	6.07	No	No	2	3	6
183	R:R:D365	R:R:Y369	6.9	No	No	0	1	3
184	R:R:Q439	R:R:S367	5.78	Yes	No	0	5	8
185	R:R:L372	R:R:R368	4.86	No	No	0	7	5
186	R:R:Q439	R:R:R368	3.5	Yes	No	0	5	5
187	R:R:L372	R:R:V436	4.47	No	No	0	7	4
188	R:R:L373	R:R:P374	3.28	No	No	0	4	9
189	R:R:L383	R:R:L425	6.92	No	No	0	5	5
190	R:R:L393	R:R:L410	4.15	No	No	0	8	8
191	R:R:K409	R:R:K411	5.75	No	No	0	8	8
192	R:R:K412	R:R:R416	6.19	No	No	0	7	9
193	R:R:F413	R:R:I417	7.54	No	No	0	8	8
194	R:R:R416	R:R:W493	13.99	No	Yes	1	9	9
195	R:R:F420	R:R:S489	6.61	Yes	No	1	9	7
196	R:R:F420	R:R:W493	5.01	Yes	Yes	1	9	9
197	R:R:F492	R:R:L423	4.87	No	No	0	7	7
198	R:R:L428	R:R:Y424	4.69	No	Yes	0	7	7
199	R:R:V486	R:R:Y424	5.05	No	Yes	1	7	7
200	R:R:P427	R:R:V426	3.53	No	No	0	8	5
201	R:R:P427	R:R:V486	3.53	No	No	0	8	7
202	R:R:L431	R:R:Y435	14.07	No	No	0	6	5
203	R:R:L431	R:R:T483	7.37	No	No	0	6	5
204	R:R:C434	R:R:K479	6.47	No	No	0	7	8
205	R:R:K479	R:R:Y435	3.58	No	No	0	8	5
206	R:R:N441	R:R:Y437	5.81	No	No	2	5	8
207	R:R:W445	R:R:Y437	7.72	Yes	No	2	9	8
208	R:R:L475	R:R:Y437	7.03	No	No	0	6	8
209	R:R:E438	R:R:R442	18.61	No	No	2	8	6
210	R:R:E438	R:R:W445	5.45	No	Yes	2	8	9
211	R:R:E438	R:R:F476	11.66	No	No	2	8	6
212	R:R:Q439	R:R:R442	3.5	Yes	No	2	5	6
213	R:R:N441	R:R:V440	5.91	No	No	0	5	3
214	R:R:N441	R:R:W445	12.43	No	Yes	2	5	9
215	R:R:P471	R:R:W445	8.11	No	Yes	0	8	9
216	R:R:F476	R:R:W445	5.01	No	Yes	2	6	9
217	R:R:I447	R:R:Q464	4.12	Yes	No	6	2	1
218	R:R:H453	R:R:W449	10.58	Yes	No	8	5	5
219	R:R:P460	R:R:V450	3.53	No	No	0	5	4
220	R:R:C461	R:R:V450	3.42	No	No	0	9	4
221	R:R:D452	R:R:H453	11.35	No	Yes	0	4	5
222	R:R:H453	R:R:Q456	4.95	Yes	No	0	5	3
223	R:R:Q456	R:R:Y457	4.51	No	No	0	3	4
224	R:R:I459	R:R:P460	3.39	No	No	0	5	5
225	R:R:I459	R:R:P462	5.08	No	No	0	5	4
226	R:R:Q464	R:R:Y463	7.89	No	No	0	1	1
227	R:R:K468	R:R:R470	3.71	No	No	0	1	5
228	R:R:P471	R:R:R470	8.65	No	No	0	8	5
229	R:R:L473	R:R:M477	4.24	No	No	0	5	7
230	R:R:K479	R:R:Y480	5.97	No	Yes	0	8	7
231	R:R:I485	R:R:L481	5.71	No	No	0	5	5
232	R:R:I485	R:R:M482	4.37	No	No	0	5	7
233	R:R:I485	R:R:I488	4.42	No	Yes	0	5	7
234	R:R:F492	R:R:V491	3.93	No	No	0	7	8
235	R:R:A212	R:R:I488	3.25	No	Yes	0	7	7
236	R:R:A490	R:R:I234	3.25	No	No	0	8	8
237	R:R:A198	R:R:M477	3.22	No	No	0	7	7
238	R:R:V301	R:R:V381	3.21	No	No	0	8	4
239	R:R:A366	R:R:K347	3.21	No	Yes	0	5	6
240	R:R:S238	R:R:T216	3.2	No	No	0	9	9
241	R:R:R225	R:R:R226	3.2	No	No	0	5	9
242	R:R:R225	R:R:R228	3.2	No	No	0	5	6
243	R:R:T216	R:R:V491	3.17	No	No	0	9	8
244	R:R:T219	R:R:V494	3.17	No	No	0	9	6
245	R:R:C357	R:R:L285	3.17	No	No	0	9	7
246	R:R:C376	R:R:L372	3.17	No	No	0	2	7
247	R:R:C376	R:R:L432	3.17	No	No	0	2	6
248	R:R:T167	R:R:T272	3.14	No	No	0	5	5
249	R:R:C185	R:R:D271	3.11	No	No	0	9	4
250	R:R:R368	R:R:Y369	3.09	No	No	0	5	3
251	R:R:I447	R:R:V450	3.07	Yes	No	0	2	4
252	R:R:I320	R:R:T306	3.04	Yes	No	0	8	7
253	R:R:F291	R:R:G336	3.01	Yes	No	0	8	7
254	R:R:F308	R:R:G312	3.01	No	No	0	7	6
255	R:R:M482	R:R:T430	3.01	No	No	0	7	4
256	R:R:L484	R:R:S245	3	No	No	0	8	8
257	R:R:L386	R:R:S421	3	No	Yes	0	8	7
258	R:R:L275	R:R:V273	2.98	No	Yes	0	7	6
259	R:R:L425	R:R:V379	2.98	No	No	0	5	7
260	R:R:L165	R:R:T272	2.95	No	No	0	7	5
261	R:R:L289	R:R:T293	2.95	Yes	No	0	6	6
262	R:R:I390	R:R:M414	2.92	No	No	0	7	8
263	R:R:I478	R:R:M482	2.92	No	No	0	5	7
264	R:R:I250	R:R:L246	2.85	No	No	0	5	4
265	R:R:I305	R:R:L309	2.85	No	No	0	5	8
266	R:R:I443	R:R:L364	2.85	No	No	0	3	3
267	R:R:K266	R:R:L267	2.82	No	No	0	3	1
268	R:R:C454	R:R:R455	2.79	No	No	0	9	4
269	R:R:D256	R:R:K262	2.77	No	No	0	6	3
270	R:R:E408	R:R:K409	2.7	No	No	0	5	8
271	R:R:E349	R:R:L275	2.65	No	No	0	8	7
272	R:R:F217	R:R:V239	2.62	No	No	0	6	4
273	R:R:R225	R:R:V224	2.62	No	No	0	5	5
274	R:R:F358	R:R:V371	2.62	Yes	No	0	7	7
275	R:R:D264	R:R:E265	2.6	No	No	0	3	5
276	R:R:K166	R:R:R163	2.48	No	No	0	5	3
277	R:R:F159	R:R:L176	2.44	No	No	0	4	4
278	R:R:F286	R:R:L343	2.44	Yes	No	0	9	8
279	R:R:D223	R:R:F227	2.39	No	No	0	8	8
280	R:R:L393	R:R:W307	2.28	No	Yes	0	8	9
281	R:R:G169	R:R:G170	2.11	No	No	0	2	4
282	R:R:G251	R:R:G355	2.11	No	No	0	9	9
283	R:R:G333	R:R:G336	2.11	No	No	0	5	7
284	R:R:P184	R:R:P186	1.95	No	No	0	6	4
285	R:R:A259	R:R:G355	1.95	No	No	0	8	9
286	R:R:A366	R:R:G360	1.95	No	No	0	5	8
287	R:R:C454	R:R:P460	1.88	No	No	0	9	5
288	R:R:A182	R:R:P183	1.87	No	Yes	0	6	5
289	R:R:G418	R:R:S421	1.86	No	Yes	0	7	7
290	R:R:G422	R:R:S421	1.86	No	Yes	0	4	7
291	R:R:G350	R:R:V273	1.84	No	Yes	0	8	6
292	R:R:G276	R:R:V348	1.84	No	No	0	7	8
293	R:R:G433	R:R:V436	1.84	No	No	0	5	4
294	R:R:G487	R:R:T213	1.82	No	No	0	9	8
295	R:R:G158	R:R:I157	1.76	No	No	0	3	1
296	R:R:G172	R:R:L275	1.71	No	No	0	3	7
297	R:R:G255	R:R:L254	1.71	No	No	0	7	4
298	R:R:G270	R:R:L269	1.71	No	No	0	1	3
299	R:R:A319	R:R:S316	1.71	No	No	0	7	6
300	R:R:A465	R:R:S451	1.71	No	No	0	1	3
301	R:R:D256	R:R:G255	1.68	No	No	0	6	7
302	R:R:A469	R:R:T444	1.68	No	No	0	3	1
303	R:R:A467	R:R:T448	1.68	No	No	0	2	5
304	R:R:G170	R:R:Q171	1.64	No	No	0	4	4
305	R:R:A310	R:R:I320	1.62	No	Yes	0	8	8
306	R:R:A467	R:R:I447	1.62	No	Yes	0	2	2
307	R:R:A344	R:R:M345	1.61	No	No	0	7	5
308	R:R:S451	R:R:T448	1.6	No	No	0	3	5
309	R:R:T339	R:R:V340	1.59	No	No	0	8	7
310	R:R:T444	R:R:T448	1.57	No	No	0	1	5
311	R:R:I415	R:R:V419	1.54	No	No	0	6	5
312	R:R:K166	R:R:S168	1.53	No	No	0	5	6
313	R:R:K266	R:R:S168	1.53	No	No	0	3	6
314	R:R:L221	R:R:V224	1.49	No	No	0	5	5
315	R:R:L423	R:R:V419	1.49	No	No	0	7	5
316	R:R:N279	R:R:V274	1.48	No	No	0	7	6
317	R:R:I415	R:R:K411	1.45	No	No	0	6	8
318	R:R:E318	R:R:S316	1.44	No	No	0	9	6
319	R:R:I390	R:R:L387	1.43	No	No	0	7	4
320	R:R:L338	R:R:M341	1.41	No	No	0	7	4
321	R:R:D264	R:R:K266	1.38	No	No	0	3	3
322	R:R:K323	R:R:Q322	1.36	No	No	0	6	5
323	R:R:E472	R:R:L475	1.33	No	No	0	6	6
324	R:R:F197	R:R:S200	1.32	No	No	0	6	3
325	R:R:S206	R:R:Y248	1.27	No	Yes	0	7	8
326	R:R:F208	R:R:I488	1.26	No	Yes	0	5	7
327	R:R:F190	R:R:L195	1.22	Yes	No	0	7	7
328	R:R:I178	R:R:W160	1.17	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H164	7.415	4	0	5
2	R:R:F175	8.07	4	0	6
3	R:R:Q180	8.7475	4	0	5
4	R:R:P183	5.2675	4	0	5
5	R:R:F190	4.496	5	0	7
6	R:R:F220	6.21	4	0	8
7	R:R:Y229	7.394	5	4	9
8	R:R:Y236	5.7225	4	5	6
9	R:R:Y237	9.34	4	1	8
10	R:R:Y241	6.124	5	1	8
11	R:R:Y248	4.57143	7	3	8
12	R:R:V273	3.195	4	0	6
13	R:R:F286	5.434	5	10	9
14	R:R:L289	4.234	5	3	6
15	R:R:Y290	6.266	5	10	9
16	R:R:F291	5.742	5	0	8
17	R:R:F292	8.445	4	0	9
18	R:R:M294	5.13	4	0	8
19	R:R:W299	11.8275	4	5	9
20	R:R:W300	6.184	5	0	9
21	R:R:W307	5.84	5	0	9
22	R:R:W315	6.5725	4	4	8
23	R:R:I320	3.746	5	4	8
24	R:R:P335	3.98	5	0	9
25	R:R:K347	5.34	4	0	6
26	R:R:F358	4.0275	4	0	7
27	R:R:F420	7.516	5	1	9
28	R:R:S421	2.6075	4	0	7
29	R:R:Y424	6.16333	6	1	7
30	R:R:Q439	5.1925	4	2	5
31	R:R:W445	7.744	5	2	9
32	R:R:I447	3.145	4	6	2
33	R:R:H453	9.0175	4	8	5
34	R:R:Y480	6.68833	6	3	7
35	R:R:I488	3.05	4	0	7
36	R:R:W493	9.3	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F175	R:R:L176	21.0087	6.09	Yes	No	0	6	4
2	R:R:F159	R:R:L176	19.8899	2.44	No	No	0	4	4
3	R:R:H164	R:R:Y457	37.7411	11.98	Yes	No	0	5	4
4	R:R:H164	R:R:L165	16.2351	3.86	Yes	No	0	5	7
5	R:R:H164	R:R:L269	20.6642	6.43	Yes	No	0	5	3
6	R:R:L165	R:R:T272	12.9036	2.95	No	No	0	7	5
7	R:R:T167	R:R:T272	11.767	3.14	No	No	0	5	5
8	R:R:Q180	R:R:T167	10.6304	8.5	Yes	No	0	5	5
9	R:R:R368	R:R:Y369	10.8649	3.09	No	No	0	5	3
10	R:R:Q439	R:R:R368	17.7908	3.5	Yes	No	0	5	5
11	R:R:Q439	R:R:R442	19.9219	3.5	Yes	No	2	5	6
12	R:R:E438	R:R:R442	23.3671	18.61	No	No	2	8	6
13	R:R:E438	R:R:F476	23.7897	11.66	No	No	2	8	6
14	R:R:F190	R:R:F476	34.8677	6.43	Yes	No	0	7	6
15	R:R:F190	R:R:Y189	73.6104	4.13	Yes	No	0	7	5
16	R:R:N187	R:R:Y189	33.2516	10.47	No	No	0	5	5
17	R:R:N187	R:R:Y362	26.3186	4.65	No	No	0	5	5
18	R:R:P183	R:R:Y362	25.5123	5.56	Yes	No	0	5	5
19	R:R:F175	R:R:P183	25.0648	10.11	Yes	Yes	0	6	5
20	R:R:D271	R:R:L269	13.0279	10.86	No	No	0	4	3
21	R:R:W449	R:R:Y189	41.2325	3.86	No	No	0	5	5
22	R:R:Q456	R:R:Y457	36.9419	4.51	No	No	0	3	4
23	R:R:H453	R:R:Q456	37.7411	4.95	Yes	No	0	5	3
24	R:R:H453	R:R:W449	39.3358	10.58	Yes	No	8	5	5
25	R:R:F190	R:R:L473	93.9442	4.87	Yes	No	0	7	5
26	R:R:L473	R:R:M477	94.3101	4.24	No	No	0	5	7
27	R:R:F201	R:R:M477	95.198	6.22	No	No	0	8	7
28	R:R:F201	R:R:V205	95.61	6.55	No	No	0	8	6
29	R:R:L481	R:R:V205	96.0149	4.47	No	No	0	5	6
30	R:R:I485	R:R:L481	96.4127	5.71	No	No	0	5	5
31	R:R:I485	R:R:I488	97.9329	4.42	No	Yes	0	5	7
32	R:R:C209	R:R:I488	98.9984	3.27	No	Yes	0	8	7
33	R:R:C209	R:R:L484	99.3394	7.94	No	No	0	8	8
34	R:R:L484	R:R:Y248	100	7.03	No	Yes	0	8	8
35	R:R:L289	R:R:Y248	99.897	5.86	Yes	Yes	3	6	8
36	R:R:L289	R:R:M247	88.7444	4.24	Yes	No	0	6	7
37	R:R:L288	R:R:M247	92.4028	4.24	No	No	0	5	7
38	R:R:F292	R:R:L288	92.385	3.65	Yes	No	0	9	5
39	R:R:C240	R:R:F292	55.3436	5.59	No	Yes	0	9	9
40	R:R:C240	R:R:G296	54.4734	3.92	No	No	0	9	7
41	R:R:G296	R:R:Y241	53.5962	4.35	No	Yes	0	7	8
42	R:R:F291	R:R:F292	86.0238	10.72	Yes	Yes	0	8	9
43	R:R:F291	R:R:W332	89.1316	4.01	Yes	No	0	8	9
44	R:R:W299	R:R:W332	44.7345	18.74	Yes	No	5	9	9
45	R:R:W299	R:R:Y236	43.3138	8.68	Yes	Yes	5	9	6
46	R:R:I235	R:R:Y236	31.8061	3.63	No	Yes	0	7	6
47	R:R:F220	R:R:I235	29.9663	8.79	Yes	No	0	8	7
48	R:R:H328	R:R:W332	43.8714	8.46	No	No	5	9	9
49	R:R:H328	R:R:Y236	43.1398	5.44	No	Yes	5	9	6
50	R:R:F220	R:R:T216	19.0623	3.89	Yes	No	0	8	9
51	R:R:R232	R:R:Y236	56.7785	5.14	No	Yes	0	8	6
52	R:R:R232	R:R:Y229	55.1838	10.29	No	Yes	0	8	9
53	R:R:I320	R:R:Y229	42.9018	4.84	Yes	Yes	4	8	9
54	R:R:I320	R:R:T306	24.6457	3.04	Yes	No	0	8	7
55	R:R:P230	R:R:T306	22.781	3.5	No	No	0	9	7
56	R:R:C317	R:R:P230	20.9093	3.77	No	No	0	6	9
57	R:R:C317	R:R:R228	13.2765	8.36	No	No	9	6	6
58	R:R:R225	R:R:R228	11.4438	3.2	No	No	0	5	6
59	R:R:E231	R:R:W493	13.3582	7.63	No	Yes	1	9	9
60	R:R:F420	R:R:W493	16.7572	5.01	Yes	Yes	1	9	9
61	R:R:F420	R:R:Y237	18.9522	13.41	Yes	Yes	1	9	8
62	R:R:Y237	R:R:Y241	20.5257	11.91	Yes	Yes	1	8	8
63	R:R:E231	R:R:F413	12.314	3.5	No	No	0	9	8
64	R:R:Y241	R:R:Y424	22.7242	4.96	Yes	Yes	1	8	7
65	R:R:F358	R:R:L289	15.5603	3.65	Yes	Yes	0	7	6
66	R:R:F358	R:R:Y290	15.7841	6.19	Yes	Yes	0	7	9
67	R:R:F286	R:R:Y290	11.1525	8.25	Yes	Yes	10	9	9
68	R:R:M294	R:R:Y290	15.7343	9.58	Yes	Yes	0	8	9
69	R:R:M294	R:R:P335	15.4928	3.35	Yes	Yes	0	8	9
70	R:R:W300	R:R:Y424	17.2403	11.58	Yes	Yes	0	9	7
71	R:R:I320	R:R:W315	11.5468	3.52	Yes	Yes	4	8	8
72	R:R:T216	R:R:V491	15.2833	3.17	No	No	0	9	8
73	R:R:F492	R:R:V491	13.3831	3.93	No	No	0	7	8
74	R:R:F492	R:R:L423	11.4758	4.87	No	No	0	7	7
75	R:R:F476	R:R:W445	10.0906	5.01	No	Yes	2	6	9
76	R:R:F159	R:R:I447	16.4944	3.77	No	Yes	6	4	2
77	R:R:F291	R:R:P335	15.3863	5.78	Yes	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8JH7

PDB Summary
PDB	8JH7
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD6
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.2
Date	2024-01-17
D.O.I.	10.1038/s41421-023-00627-y

Net Summary
I_min	3.27
Number of Linked Nodes	304
Number of Links	328
Number of Hubs	36
Number of Links mediated by Hubs	142
Number of Communities	10
Number of Nodes involved in Communities	50
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	56835
Length Of Smallest Path	3
Average Path Length	19.7417
Length of Longest Path	46
Minimum Path Strength	1.455
Average Path Strength	5.85406
Maximum Path Strength	15.135
Minimum Path Correlation	0.7
Average Path Correlation	0.924054
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.5641
Average % Of Corr. Nodes	40.0719
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.2581
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O60353
Sequence	>8JH7_Chain_R I G F W C P R H L K T S G G Q G Y K F L G I D Q C A P P C P N M Y F K S D E L E F A K S F I G T V S I F C L C A T L F T F L T F L I D V R R F R Y P E R P I I Y Y S V C Y S I V S L M Y F I G F L L G D S T A C N K A D E K L E L G D T V V L G S Q N K A C T V L F M L L Y F F T M A G T V W W V I L T I T W F L A A G R K W S C E A I E Q K A V W F H A V A W G T P G F L T V M L L A M N K V E G D N I S G V C F V G L Y D L D A S R Y F V L L P L C L C V F V G L S L L L A G I I S L N H E K L K K F M I R I G V F S G L Y L V P L V T L L G C Y V Y E Q V N R I T W E I T W V S D H C R Q Y H I P C P Y Q A K A K A R P E L A L F M I K Y L M T L I V G I S A V F W V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHB	F	Protein	Frizzled	FZD₆	Homo sapiens	-	-	chim(NtGsXLas-Gs)/&β;1/&γ;2	3.3	2024-01-17	10.1038/s41421-023-00627-y

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JH7.zip

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