Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R42 5.3875429
2A:A:L43 3.4525457
3A:A:L44 6.77409
4A:A:L45 3.585408
5A:A:S51 3.46409
6A:A:I56 4.208557
7A:A:F212 4.574559
8A:A:F219 6.16333658
9A:A:H220 10.975427
10A:A:M221 4.6475458
11A:A:F222 9.302527
12A:A:Q227 4.34833629
13A:A:R228 6.59429
14A:A:E230 8.125429
15A:A:K233 5.63833629
16A:A:W234 4.59857729
17A:A:F238 7.40667629
18A:A:F246 3.88333649
19A:A:V247 3.898557
20A:A:V248 4.12447
21A:A:D249 5.16754108
22A:A:S250 3.3825446
23A:A:Y253 4.8225448
24A:A:L270 4.6675406
25A:A:F273 6.23749
26A:A:W277 9.17333646
27A:A:R280 5.8875415
28A:A:W281 14.27415
29A:A:L289 3.78167649
30A:A:F290 4.62759
31A:A:L291 3.7275448
32A:A:N292 3.6425459
33A:A:K293 5.43254109
34A:A:Q294 6.7275446
35A:A:F312 4.322548
36A:A:E314 3.3725446
37A:A:F315 10.74546
38A:A:Y318 5.812546
39A:A:P321 4.015445
40A:A:E330 5.21443
41A:A:D331 5.915444
42A:A:V334 3.892544
43A:A:K338 5.842545
44A:A:Y339 6.014543
45A:A:F340 7.314547
46A:A:I341 3.765448
47A:A:R342 7.3225444
48A:A:E344 5.528545
49A:A:F345 4.595648
50A:A:S349 3.692547
51A:A:C359 3.1725445
52A:A:Y360 6.73333658
53A:A:H362 6.17459
54A:A:F363 6.712545
55A:A:T364 5.99459
56A:A:N371 6.5775459
57A:A:I375 3.0725459
58A:A:F376 6.31333658
59A:A:Y391 6.25114
60B:B:T34 4.12415
61B:B:I37 4.068512
62B:B:H54 7.98143719
63B:B:I58 5.71419
64B:B:M61 2.76416
65B:B:W63 7.56833617
66B:B:L69 3.4625405
67B:B:L70 7.475415
68B:B:S72 6.3475419
69B:B:Q75 8.9975429
70B:B:K78 4408
71B:B:W82 8.01714719
72B:B:Y85 7.194514
73B:B:K89 5.884519
74B:B:H91 5.6075405
75B:B:L95 5.64428
76B:B:W99 10.1733629
77B:B:M101 5.335429
78B:B:Y105 4.864506
79B:B:S108 5.795406
80B:B:A113 2.3925429
81B:B:C114 4.034528
82B:B:G115 2.3275429
83B:B:L117 3.3775829
84B:B:Y124 5.48857726
85B:B:H142 7.058529
86B:B:Y145 4.765828
87B:B:L146 3.305427
88B:B:C149 3.818528
89B:B:R150 5.645406
90B:B:F151 6.605429
91B:B:I157 5.515427
92B:B:T159 4.668529
93B:B:S160 3.514566
94B:B:C166 3.2675468
95B:B:L168 4.506566
96B:B:W169 8.63429728
97B:B:F180 6.915667
98B:B:H183 7.03167669
99B:B:D186 6.22529
100B:B:V187 3.9325469
101B:B:L190 4.75465
102B:B:F199 6.476569
103B:B:S201 4.2575469
104B:B:G202 2.275486
105B:B:C204 4.73333627
106B:B:D205 6.565469
107B:B:K209 10.665466
108B:B:W211 9.208568
109B:B:F222 10.6325488
110B:B:H225 7.14125889
111B:B:D228 7.402529
112B:B:I232 4.856588
113B:B:F235 6.22667616
114B:B:P236 5.6425417
115B:B:F241 5.52143786
116B:B:T243 5.556588
117B:B:D246 5.855429
118B:B:D247 9.03489
119B:B:T249 6.39486
120B:B:C250 2.826518
121B:B:R251 8.32167688
122B:B:L252 3.455407
123B:B:F253 8.455686
124B:B:Y264 6.7615
125B:B:C271 3.934515
126B:B:T274 4.14418
127B:B:V276 2.48416
128B:B:F278 5.33333617
129B:B:R283 4.89719
130B:B:L285 5.14416
131B:B:G288 2.3225417
132B:B:Y289 6.72429717
133B:B:D290 7.112516
134B:B:N295 6.0475416
135B:B:L300 5.974516
136B:B:K301 5.262515
137B:B:H311 8.0975419
138B:B:R314 13.026518
139B:B:V315 3.325417
140B:B:L318 2.6075406
141B:B:T321 7.75417
142B:B:G324 2.8025409
143B:B:T329 3.83667618
144B:B:G330 1.8125415
145B:B:W332 9.415609
146B:B:D333 6.1875419
147B:B:L336 4.67517
148B:B:K337 6.122516
149B:B:W339 7.946519
150G:G:R27 5.815408
151G:G:Y40 9.8175416
152G:G:D48 5.562519
153G:G:L50 3.9725419
154G:G:L51 2.722516
155G:G:F61 5.16625818
156R:R:P183 4.1485125
157R:R:N187 4.7825475
158R:R:F190 4.42571777
159R:R:E194 2.925477
160R:R:I202 3.91577
161R:R:T216 4.796539
162R:R:R228 4.73406
163R:R:Y229 4.65833609
164R:R:P230 5.44254119
165R:R:R232 3.9825408
166R:R:P233 4.716538
167R:R:I234 5.56538
168R:R:I235 5.975407
169R:R:Y236 7.9725436
170R:R:Y237 5.954538
171R:R:Y241 4.86143738
172R:R:Y248 4.686578
173R:R:F249 5.985406
174R:R:L254 1.9375404
175R:R:L275 3.3185127
176R:R:C282 5.53439
177R:R:F286 6.58439
178R:R:Y290 5.81714739
179R:R:F291 5.07538
180R:R:F292 3.976539
181R:R:M294 4.8725438
182R:R:T297 3.1075435
183R:R:W299 9.35639
184R:R:W300 8.93539
185R:R:I302 4.756536
186R:R:W307 5.2775439
187R:R:W315 8.23754198
188R:R:I320 5.73254198
189R:R:K323 3.9454196
190R:R:W332 5.352539
191R:R:P335 2.99539
192R:R:T339 3.3575438
193R:R:L342 5.945436
194R:R:V348 5.0225438
195R:R:D351 4.906579
196R:R:I353 7.7925477
197R:R:S354 4.164578
198R:R:V356 3.8175478
199R:R:F358 4.1475407
200R:R:V359 3.384539
201R:R:Y362 5.344125
202R:R:L375 4.1125407
203R:R:Q407 4.43254147
204R:R:F413 3.3275438
205R:R:I417 4.088538
206R:R:F420 6.775439
207R:R:Y424 7.40143737
208R:R:L428 4.845437
209R:R:Y435 3.2425405
210R:R:Y437 8.20254138
211R:R:W445 9.5265139
212R:R:W449 7.99495
213R:R:Y457 5.3125494
214R:R:I459 4.3925405
215R:R:P462 2.846594
216R:R:P471 9.34408
217R:R:K479 4.816578
218R:R:Y480 5.98477
219R:R:L484 5.7775478
220R:R:V486 4.4437
221R:R:S489 4.044537
222R:R:A490 2.54538
223R:R:W493 10.938539
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L117 B:B:M101 24.88992.83YesYes299
2A:A:W234 B:B:L117 12.64652.28YesYes299
3A:A:R231 A:A:W234 56.09236NoYes099
4A:A:L46 A:A:R231 55.75243.64NoNo089
5A:A:G47 A:A:L46 1001.71NoNo098
6A:A:G47 A:A:S51 34.63253.71NoYes099
7A:A:S51 A:A:V247 34.09324.85YesYes097
8A:A:F290 A:A:V247 33.38582.62YesYes597
9A:A:F290 A:A:I375 32.57732.51YesYes599
10A:A:F219 A:A:I375 64.8032.51YesYes589
11B:B:M101 B:B:Y145 13.64583.59YesYes298
12A:A:W234 B:B:Y145 43.52721.93YesYes298
13A:A:F238 B:B:L117 12.60582.44YesYes299
14A:A:F238 A:A:L44 44.605517.05YesYes099
15A:A:L44 A:A:L46 44.2712.77YesNo098
16A:A:G47 A:A:K53 65.34551.74NoNo099
17A:A:K53 A:A:L45 65.22242.82NoYes098
18A:A:I245 A:A:L45 32.39015.71NoYes078
19A:A:I245 A:A:I375 32.3064.42NoYes579
20A:A:L45 A:A:M221 32.8032.83YesYes088
21A:A:F212 A:A:M221 32.5342.49YesYes598
22A:A:F212 A:A:F219 32.34812.86YesYes598
23A:A:F219 A:A:H41 95.84565.66YesNo086
24A:A:H41 A:A:I383 95.58475.3NoNo068
25A:A:D240 B:B:W99 10.03916.7NoYes069
26B:B:D186 B:B:Y145 10.2169.2YesYes298
27A:A:K233 B:B:Y145 10.22283.58YesYes298
28A:A:K233 B:B:C204 10.01954.85YesYes297
29B:B:C204 B:B:D186 10.04333.11YesYes279
30B:B:M188 B:B:Y145 10.03797.18NoYes288
31B:B:C204 B:B:M188 10.01123.24YesNo278
32B:B:M101 B:B:Y59 31.529113.17YesNo098
33B:B:W332 B:B:Y59 41.32922.89YesNo098
34B:B:R314 B:B:W332 34.932819.99YesYes089
35B:B:K57 B:B:W332 19.846616.24NoYes099
36B:B:D290 B:B:R314 18.2715.48YesYes168
37B:B:C271 B:B:D290 17.6563.11YesYes156
38A:A:H387 A:A:I383 95.45435.3NoNo088
39A:A:H387 A:A:Y391 95.04873.27NoYes1184
40A:A:L393 A:A:Y391 76.94472.34NoYes084
41A:A:Y391 R:R:C317 17.49189.41YesNo1146
42A:A:L393 R:R:F413 74.71373.65NoYes088
43R:R:C317 R:R:P230 17.23953.77NoYes1169
44B:B:F199 B:B:V213 25.56752.62YesNo094
45B:B:R214 B:B:V213 25.49559.15NoNo094
46B:B:R197 B:B:R214 13.75337.46NoNo059
47B:B:D195 B:B:R197 13.59963.57NoNo055
48B:B:A193 B:B:D195 13.4463.09NoNo045
49B:B:A193 B:B:F234 12.98494.16NoNo045
50B:B:F234 B:B:V200 12.677510.49NoNo056
51B:B:F241 B:B:V200 10.51382.62YesNo866
52B:B:F222 B:B:F241 12.68113.93YesYes886
53B:B:D258 B:B:F222 12.070310.75NoYes878
54B:B:D258 G:G:R27 11.76164.76NoYes078
55G:G:I25 G:G:R27 10.83418.77NoYes028
56G:G:E22 G:G:I25 10.52496.83NoNo092
57B:B:E215 B:B:R214 11.58992.33NoNo039
58B:B:D212 B:B:E215 11.43616.5NoNo093
59B:B:D212 B:B:R219 11.12773.57NoNo1795
60B:B:L210 B:B:R219 10.97482.43NoNo055
61B:B:L210 B:B:L255 10.66724.15NoNo056
62B:B:F241 B:B:L255 10.51342.44YesNo066
63B:B:C271 B:B:Y289 16.91394.03YesYes157
64B:B:W297 B:B:Y289 14.02194.82NoYes187
65B:B:W297 B:B:Y264 13.87659.65NoYes185
66G:G:D48 G:G:L51 11.20032.71YesYes196
67G:G:D48 G:G:L50 12.27494.07YesYes199
68B:B:C204 B:B:G185 29.91911.96YesNo075
69B:B:F199 B:B:W211 25.40599.02YesYes698
70B:B:S201 B:B:W211 13.37456.18YesYes698
71B:B:D205 B:B:H183 29.5383.78YesYes699
72B:B:K209 B:B:W211 13.37666.96YesYes668
73B:B:C317 B:B:S316 25.57083.44NoNo079
74R:R:F413 R:R:I417 70.57042.51YesYes388
75R:R:I417 R:R:W493 68.17122.35YesYes389
76R:R:F420 R:R:W493 65.305713.03YesYes399
77R:R:F420 R:R:S489 65.19546.61YesYes397
78R:R:S489 R:R:Y424 64.21372.54YesYes377
79R:R:T297 R:R:Y424 44.09292.5YesYes357
80R:R:M294 R:R:T297 26.09433.01YesYes385
81R:R:M294 R:R:Y290 25.680511.97YesYes389
82R:R:F358 R:R:L361 15.9462.44YesNo077
83R:R:L361 R:R:Y362 13.43434.69NoYes075
84R:R:P183 R:R:Y362 10.50888.34YesYes1255
85R:R:P183 R:R:P184 13.42451.95YesNo056
86R:R:P184 R:R:W449 12.30646.76NoYes065
87R:R:L375 R:R:T297 18.00584.42YesYes075
88R:R:L375 R:R:Y435 35.1372.34YesYes075
89R:R:F358 R:R:Y435 13.95452.06YesYes075
90R:R:L428 R:R:Y424 18.22223.52YesYes377
91R:R:L375 R:R:L428 17.96286.92YesYes077
92R:R:V359 R:R:Y290 16.21572.52YesYes399
93R:R:E349 R:R:V359 15.8462.85NoYes089
94R:R:E349 R:R:L275 10.23742.65NoYes087
95R:R:F175 R:R:Y173 10.4127.22NoNo065
96R:R:K479 R:R:Y435 20.37524.78YesYes085
97R:R:K479 R:R:Y480 18.97432.39YesYes787
98R:R:P230 R:R:Y229 14.35224.17YesYes099
99A:A:F238 B:B:W99 29.822514.03YesYes299
100B:B:S316 B:B:W332 25.71914.94NoYes099
101B:B:C317 B:B:M61 18.79293.24NoYes076
102B:B:Q75 B:B:W99 19.889512.05YesYes299
103B:B:D205 B:B:G185 29.85465.03YesNo095
104B:B:R314 B:B:T274 15.96065.17YesYes188
105B:B:H183 B:B:S201 14.1274.18YesYes699
106B:B:H183 B:B:K209 13.759215.72YesYes696
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8JHB
Class F
SubFamily Protein
Type Frizzled
SubType FZD6
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGsXLas-Gs)/Beta1/Gamma2
PDB Resolution 3.3
Date 2024-01-17 
D.O.I. 10.1038/s41421-023-00627-y
Net Summary
Imin 1.71
Number of Linked Nodes 916
Number of Links 1221
Number of Hubs 223
Number of Links mediated by Hubs 766
Number of Communities 20
Number of Nodes involved in Communities 343
Number of Links involved in Communities 538
Path Summary
Number Of Nodes in MetaPath 107
Number Of Links MetaPath 106
Number of Shortest Paths 10700273
Length Of Smallest Path 3
Average Path Length 37.0231
Length of Longest Path 70
Minimum Path Strength 1.115
Average Path Strength 4.92972
Maximum Path Strength 20.49
Minimum Path Correlation 0.7
Average Path Correlation 0.99784
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 41.5425
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.8117
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8JHB_Chain_A
SKTEDKRAQ KRAEKKRSK LIDKQLQDE KMGYMCTHR LLLLGADNS 
GKSTIVKQM RILHTSGIF ETKFQVDKV NFHMFDVGG QRDERRKWI 
QCFNDVTAI IFVVDSSDY NRLQEALNL FKSIWNNRW LRTISVILF 
LNKQDLLAE KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT 
RAKYFIRDE FLRISTASG DGRHYCYPH FTCAVDTEN ARRIFNDCR 
DIIQRMHLR QYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8JHB_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8JHB_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtO60353
Sequence
>8JHB_Chain_R
IGFWCPRHL KTSGGQGYK FLGIDQCAP PCPNMYFKS DELEFAKSF 
IGTVSIFCL CATLFTFLT FLIDVRRFR YPERPIIYY SVCYSIVSL 
MYFIGFLLG DSTACNKEL GDTVVLGSQ NKACTVLFM LLYFFTMAG 
TVWWVILTI TWFLAAGRK WSCEAIEQK AVWFHAVAW GTPGFLTVM 
LLAMNKVEG DNISGVCFV GLYDLDASR YFVLLPLCL CVFVGLSLL 
LAGIISLNH VRQVIQHDG RNQEKLKKF MIRIGVFSG LYLVPLVTL 
LGCYVYEQV NRITWEITW VSDHCRQYH IPCPYQAKA KARPELALF 
MIKYLMTLI VGISAVFWV G


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JH7FProteinFrizzledFZD6Homo sapiens---3.22024-01-1710.1038/s41421-023-00627-y




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JHB.zip



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