psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C165	R:R:P166	3.77	No	Yes	5	9	6
2	R:R:C165	R:R:L169	4.76	No	No	5	9	6
3	R:R:C165	R:R:C185	7.28	No	No	0	9	9
4	R:R:L169	R:R:P166	6.57	No	Yes	5	6	6
5	R:R:P166	R:R:Y461	5.56	Yes	No	0	6	4
6	R:R:D172	R:R:I171	4.2	No	No	0	4	4
7	R:R:I171	R:R:Y177	13.3	No	Yes	0	4	6
8	R:R:D184	R:R:P173	11.27	No	No	0	6	3
9	R:R:H282	R:R:L175	6.43	No	No	0	6	3
10	R:R:S186	R:R:Y177	6.36	No	Yes	0	6	6
11	R:R:N265	R:R:Y177	5.81	No	Yes	0	4	6
12	R:R:H282	R:R:Y177	10.89	No	Yes	0	6	6
13	R:R:F179	R:R:L180	18.27	No	No	0	5	4
14	R:R:F179	R:R:P187	24.56	No	Yes	0	5	5
15	R:R:E450	R:R:L180	3.98	No	No	0	6	4
16	R:R:D184	R:R:R183	9.53	No	No	0	6	3
17	R:R:P187	R:R:S186	3.56	Yes	No	0	5	6
18	R:R:S186	R:R:T276	9.59	No	No	0	6	5
19	R:R:P187	R:R:V277	7.07	Yes	No	0	5	6
20	R:R:P187	R:R:Y366	11.13	Yes	No	0	5	5
21	R:R:P188	R:R:W453	5.4	No	No	0	5	5
22	R:R:C189	R:R:P190	3.77	Yes	No	2	9	3
23	R:R:C189	R:R:D260	4.67	Yes	No	2	9	6
24	R:R:C189	R:R:C264	7.28	Yes	No	2	9	9
25	R:R:C189	R:R:S275	6.89	Yes	No	2	9	3
26	R:R:P190	R:R:S275	3.56	No	No	2	3	3
27	R:R:N191	R:R:R457	7.23	No	Yes	0	4	4
28	R:R:M192	R:R:Y193	8.38	No	Yes	2	7	5
29	R:R:F194	R:R:M192	3.73	No	No	2	6	7
30	R:R:M192	R:R:N356	4.21	No	Yes	2	7	6
31	R:R:F194	R:R:Y193	12.38	No	Yes	2	6	5
32	R:R:P475	R:R:Y193	11.13	No	Yes	0	8	5
33	R:R:F480	R:R:Y193	4.13	No	Yes	0	6	5
34	R:R:F194	R:R:L199	6.09	No	No	0	6	6
35	R:R:E198	R:R:R195	6.98	No	No	0	7	4
36	R:R:E198	R:R:L477	17.23	No	No	0	7	5
37	R:R:A202	R:R:L481	4.73	No	No	0	7	8
38	R:R:F256	R:R:R203	5.34	Yes	No	0	6	7
39	R:R:E259	R:R:R203	15.12	No	No	0	6	7
40	R:R:L208	R:R:Y204	5.86	No	No	0	3	4
41	R:R:F205	R:R:L481	3.65	No	No	0	7	8
42	R:R:F205	R:R:L485	4.87	No	No	0	7	7
43	R:R:G207	R:R:S210	3.71	No	No	0	6	8
44	R:R:F256	R:R:G207	7.53	Yes	No	0	6	6
45	R:R:I209	R:R:I489	4.42	No	No	0	5	5
46	R:R:F253	R:R:S210	3.96	Yes	No	0	5	8
47	R:R:F253	R:R:I211	3.77	Yes	No	0	5	3
48	R:R:C213	R:R:I492	4.91	No	No	0	8	8
49	R:R:L214	R:R:S249	6.01	No	No	0	4	8
50	R:R:L214	R:R:L250	4.15	No	No	0	4	4
51	R:R:M246	R:R:T217	4.52	Yes	No	0	5	8
52	R:R:F219	R:R:T223	6.49	No	No	6	7	9
53	R:R:F219	R:R:V498	3.93	No	Yes	6	7	7
54	R:R:S494	R:R:T220	6.4	No	No	0	8	8
55	R:R:T220	R:R:V498	4.76	No	Yes	0	8	7
56	R:R:F221	R:R:F224	4.29	No	No	0	7	9
57	R:R:F221	R:R:L225	4.87	No	No	0	7	5
58	R:R:F221	R:R:M246	7.46	No	Yes	0	7	5
59	R:R:T223	R:R:V498	4.76	No	Yes	6	9	7
60	R:R:F224	R:R:R236	6.41	No	No	0	9	9
61	R:R:F224	R:R:I239	17.58	No	No	0	9	8
62	R:R:D227	R:R:T229	4.34	No	No	0	8	4
63	R:R:D227	R:R:R230	16.68	No	No	0	8	9
64	R:R:F231	R:R:R230	4.28	No	No	0	9	9
65	R:R:E235	R:R:F231	13.99	No	No	7	9	9
66	R:R:F231	R:R:W497	4.01	No	Yes	7	9	9
67	R:R:R232	R:R:S321	10.54	No	No	0	6	6
68	R:R:E325	R:R:R232	5.82	No	No	0	7	6
69	R:R:R236	R:R:Y233	6.17	No	Yes	0	9	9
70	R:R:I324	R:R:Y233	3.63	No	Yes	8	9	9
71	R:R:E325	R:R:Y233	8.98	No	Yes	0	7	9
72	R:R:A328	R:R:Y233	5.34	No	Yes	0	8	9
73	R:R:F331	R:R:Y233	5.16	Yes	Yes	8	8	9
74	R:R:P234	R:R:S321	3.56	No	No	0	9	6
75	R:R:E235	R:R:W497	14.17	No	Yes	7	9	9
76	R:R:P237	R:R:W303	5.4	No	Yes	0	8	9
77	R:R:F424	R:R:I238	6.28	No	No	0	9	9
78	R:R:I238	R:R:W497	7.05	No	Yes	0	9	9
79	R:R:F240	R:R:I239	3.77	No	No	0	8	8
80	R:R:F240	R:R:W303	15.03	No	Yes	1	8	9
81	R:R:F240	R:R:H332	6.79	No	No	1	8	9
82	R:R:Y241	R:R:Y245	11.91	Yes	Yes	3	8	8
83	R:R:F424	R:R:Y241	13.41	No	Yes	0	9	8
84	R:R:Y241	R:R:Y428	9.93	Yes	Yes	3	8	8
85	R:R:P493	R:R:Y241	5.56	No	Yes	0	8	8
86	R:R:M246	R:R:V243	4.56	Yes	No	0	5	5
87	R:R:C244	R:R:F296	5.59	No	No	1	9	8
88	R:R:C244	R:R:G300	3.92	No	No	0	9	8
89	R:R:C244	R:R:W336	3.92	No	Yes	1	9	9
90	R:R:V248	R:R:Y245	3.79	No	Yes	0	7	8
91	R:R:G300	R:R:Y245	4.35	No	Yes	0	8	8
92	R:R:Y245	R:R:Y428	5.96	Yes	Yes	3	8	8
93	R:R:V490	R:R:Y245	10.09	No	Yes	3	8	8
94	R:R:M246	R:R:M247	4.33	Yes	No	0	5	5
95	R:R:I292	R:R:M247	4.37	No	No	0	5	5
96	R:R:F296	R:R:M247	9.95	No	No	0	8	5
97	R:R:L293	R:R:V248	4.47	Yes	No	0	6	7
98	R:R:I254	R:R:L250	4.28	No	No	0	4	4
99	R:R:I251	R:R:I292	10.3	No	No	0	6	5
100	R:R:I251	R:R:L293	4.28	No	Yes	0	6	6
101	R:R:F252	R:R:L293	4.87	Yes	Yes	0	8	6
102	R:R:F252	R:R:S358	5.28	Yes	Yes	4	8	8
103	R:R:F252	R:R:V360	9.18	Yes	No	4	8	7
104	R:R:F252	R:R:L488	12.18	Yes	No	0	8	8
105	R:R:F253	R:R:F256	4.29	Yes	Yes	0	5	6
106	R:R:F253	R:R:L257	17.05	Yes	No	0	5	4
107	R:R:L258	R:R:R261	4.86	No	No	0	4	3
108	R:R:L258	R:R:V262	5.96	No	No	0	4	6
109	R:R:C264	R:R:D260	6.22	No	No	2	9	6
110	R:R:N265	R:R:T276	4.39	No	No	0	4	5
111	R:R:N265	R:R:T278	10.24	No	No	0	4	6
112	R:R:S267	R:R:S275	4.89	No	No	0	5	3
113	R:R:I268	R:R:P269	5.08	Yes	No	0	3	2
114	R:R:I268	R:R:Q271	6.86	Yes	No	0	3	3
115	R:R:K273	R:R:T276	4.5	No	No	0	3	5
116	R:R:N356	R:R:V277	4.43	Yes	No	0	6	6
117	R:R:K284	R:R:T278	4.5	No	No	0	6	6
118	R:R:E353	R:R:Q279	7.65	No	No	0	7	7
119	R:R:G280	R:R:N350	5.09	No	No	0	6	6
120	R:R:C286	R:R:C361	7.28	No	No	0	9	9
121	R:R:F290	R:R:Y294	7.22	No	Yes	0	9	9
122	R:R:F290	R:R:L347	3.65	No	No	0	9	8
123	R:R:F290	R:R:I352	8.79	No	No	0	9	8
124	R:R:F362	R:R:L293	7.31	No	Yes	0	7	6
125	R:R:M298	R:R:Y294	11.97	No	Yes	0	7	9
126	R:R:L342	R:R:Y294	7.03	No	Yes	0	7	9
127	R:R:T343	R:R:Y294	4.99	Yes	Yes	1	9	9
128	R:R:L346	R:R:Y294	5.86	Yes	Yes	1	7	9
129	R:R:V363	R:R:Y294	3.79	No	Yes	1	9	9
130	R:R:F295	R:R:W336	7.02	Yes	Yes	1	8	9
131	R:R:F295	R:R:P339	5.78	Yes	No	0	8	9
132	R:R:F295	R:R:G340	4.52	Yes	No	1	8	7
133	R:R:F295	R:R:T343	3.89	Yes	Yes	1	8	9
134	R:R:F296	R:R:W336	5.01	No	Yes	1	8	9
135	R:R:L379	R:R:M298	4.24	No	No	0	7	7
136	R:R:M298	R:R:Y382	4.79	No	Yes	0	7	5
137	R:R:A299	R:R:W336	3.89	No	Yes	0	9	9
138	R:R:S301	R:R:Y382	7.63	No	Yes	0	6	5
139	R:R:V302	R:R:Y382	6.31	No	Yes	0	5	5
140	R:R:I306	R:R:W303	9.4	No	Yes	0	7	9
141	R:R:H332	R:R:W303	7.41	No	Yes	1	9	9
142	R:R:A335	R:R:W303	11.67	No	Yes	0	9	9
143	R:R:W303	R:R:W336	11.25	Yes	Yes	1	9	9
144	R:R:T308	R:R:W304	8.49	No	Yes	0	7	9
145	R:R:F424	R:R:W304	4.01	No	Yes	0	9	9
146	R:R:S425	R:R:W304	6.18	No	Yes	0	8	9
147	R:R:W304	R:R:Y428	11.58	Yes	Yes	0	9	8
148	R:R:L429	R:R:W304	6.83	No	Yes	0	7	9
149	R:R:V305	R:R:Y382	3.79	No	Yes	0	8	5
150	R:R:F331	R:R:I306	6.28	Yes	No	0	8	7
151	R:R:L307	R:R:T310	4.42	No	No	0	9	8
152	R:R:G386	R:R:T308	5.46	No	No	0	9	7
153	R:R:L389	R:R:T308	4.42	No	No	0	8	7
154	R:R:F331	R:R:T310	3.89	Yes	No	0	8	8
155	R:R:G393	R:R:W311	5.63	No	No	0	9	9
156	R:R:I394	R:R:W311	7.05	No	No	0	7	9
157	R:R:F417	R:R:W311	8.02	No	No	0	8	9
158	R:R:F312	R:R:V316	9.18	No	No	0	7	7
159	R:R:F312	R:R:L389	6.09	No	No	0	7	8
160	R:R:L313	R:R:W319	10.25	No	No	0	8	8
161	R:R:S396	R:R:V316	4.85	No	No	0	8	7
162	R:R:A323	R:R:W319	9.08	No	No	0	8	8
163	R:R:F331	R:R:I324	3.77	Yes	No	8	8	9
164	R:R:H332	R:R:W336	6.35	No	Yes	1	9	9
165	R:R:G340	R:R:T343	3.64	No	Yes	1	7	9
166	R:R:K351	R:R:L346	4.23	No	Yes	0	6	7
167	R:R:L346	R:R:V363	7.45	Yes	No	1	7	9
168	R:R:F374	R:R:L346	9.74	No	Yes	0	8	7
169	R:R:K351	R:R:M349	8.64	No	No	0	6	4
170	R:R:D369	R:R:K351	6.91	No	No	0	2	6
171	R:R:E353	R:R:L365	5.3	No	No	0	7	6
172	R:R:E353	R:R:Y366	4.49	No	No	0	7	5
173	R:R:D355	R:R:S358	4.42	Yes	Yes	4	9	8
174	R:R:D355	R:R:V360	4.38	Yes	No	4	9	7
175	R:R:D355	R:R:L365	13.57	Yes	No	0	9	6
176	R:R:D355	R:R:Y484	9.2	Yes	No	0	9	8
177	R:R:I357	R:R:Y484	3.63	No	No	0	8	8
178	R:R:G359	R:R:S358	3.71	No	Yes	0	9	8
179	R:R:S358	R:R:V360	4.85	Yes	No	4	8	7
180	R:R:G364	R:R:L371	5.13	No	Yes	0	8	8
181	R:R:D367	R:R:D369	13.31	No	No	0	6	2
182	R:R:A370	R:R:D367	4.63	No	No	0	6	6
183	R:R:Q443	R:R:V368	4.3	No	No	0	5	3
184	R:R:R446	R:R:V368	7.85	No	No	0	6	3
185	R:R:D369	R:R:Y373	9.2	No	No	0	2	2
186	R:R:L371	R:R:V375	4.47	Yes	No	9	8	7
187	R:R:L371	R:R:Y439	12.89	Yes	Yes	9	8	5
188	R:R:E442	R:R:L371	3.98	No	Yes	0	9	8
189	R:R:R372	R:R:Y373	7.2	No	No	0	6	2
190	R:R:Q443	R:R:R372	15.19	No	No	0	5	6
191	R:R:F374	R:R:Y373	5.16	No	No	0	8	2
192	R:R:V375	R:R:Y439	5.05	No	Yes	9	7	5
193	R:R:I436	R:R:L376	4.28	No	No	0	6	6
194	R:R:L376	R:R:Y439	5.86	No	Yes	0	6	5
195	R:R:F440	R:R:L376	14.61	No	No	0	4	6
196	R:R:P378	R:R:Y382	4.17	No	Yes	0	9	5
197	R:R:C380	R:R:I436	4.91	No	No	0	3	6
198	R:R:G386	R:R:V385	3.68	No	No	0	9	4
199	R:R:L390	R:R:S425	6.01	No	No	0	8	8
200	R:R:I395	R:R:R399	5.01	No	No	0	5	6
201	R:R:L397	R:R:L414	4.15	No	No	0	8	9
202	R:R:L397	R:R:M418	5.65	No	No	0	8	8
203	R:R:D412	R:R:V415	5.84	No	No	0	4	8
204	R:R:M418	R:R:V415	4.56	No	No	0	8	8
205	R:R:K416	R:R:R420	8.66	No	No	0	7	9
206	R:R:F417	R:R:R420	5.34	No	No	0	8	9
207	R:R:F417	R:R:W497	4.01	No	Yes	0	8	9
208	R:R:F496	R:R:V423	7.87	No	No	0	6	6
209	R:R:L427	R:R:P493	4.93	No	No	0	7	8
210	R:R:L432	R:R:Y428	8.21	No	Yes	0	7	8
211	R:R:V490	R:R:Y428	5.05	No	Yes	3	8	8
212	R:R:M486	R:R:P431	6.71	No	No	0	7	9
213	R:R:M486	R:R:V434	6.09	No	No	0	7	5
214	R:R:V435	R:R:Y439	3.79	No	Yes	0	7	5
215	R:R:C438	R:R:K483	6.47	No	No	0	7	8
216	R:R:K483	R:R:Y439	11.94	No	Yes	0	8	5
217	R:R:L479	R:R:Y441	8.21	No	No	0	6	9
218	R:R:E442	R:R:W449	5.45	No	Yes	0	9	9
219	R:R:A444	R:R:Y445	8.01	No	No	0	3	4
220	R:R:W449	R:R:Y445	5.79	Yes	No	0	9	4
221	R:R:I448	R:R:Q471	12.35	No	No	0	3	2
222	R:R:P475	R:R:W449	21.62	No	Yes	0	8	9
223	R:R:E450	R:R:W453	7.63	No	No	0	6	5
224	R:R:R457	R:R:W453	9	Yes	No	0	4	5
225	R:R:I454	R:R:P466	5.08	No	No	0	3	5
226	R:R:Q455	R:R:T470	4.25	No	No	0	3	1
227	R:R:E456	R:R:R474	4.65	No	No	0	4	4
228	R:R:E460	R:R:R457	6.98	No	Yes	0	3	4
229	R:R:R457	R:R:Y461	7.2	Yes	No	0	4	4
230	R:R:C458	R:R:C465	7.28	No	No	0	9	9
231	R:R:C465	R:R:R459	4.18	No	No	0	9	4
232	R:R:D476	R:R:I478	5.6	No	No	0	5	5
233	R:R:D476	R:R:L479	12.21	No	No	0	5	6
234	R:R:L477	R:R:L481	8.3	No	No	0	5	8
235	R:R:K483	R:R:Y484	9.55	No	No	0	8	8
236	R:R:I489	R:R:I492	4.42	No	No	0	5	8
237	R:R:G499	R:R:V498	3.68	No	Yes	0	7	7
238	R:R:P317	R:R:V316	3.53	No	No	0	7	7
239	R:R:P431	R:R:V430	3.53	No	No	0	9	5
240	R:R:E197	R:R:R195	3.49	No	No	0	4	4
241	R:R:C213	R:R:S249	3.44	No	No	0	8	8
242	R:R:A242	R:R:S494	3.42	No	No	0	8	8
243	R:R:I463	R:R:P166	3.39	No	Yes	0	5	6
244	R:R:G176	R:R:N350	3.39	No	No	0	2	6
245	R:R:I489	R:R:P431	3.39	No	No	0	5	9
246	R:R:I463	R:R:P464	3.39	No	No	0	5	5
247	R:R:I492	R:R:P493	3.39	No	No	0	8	8
248	R:R:C286	R:R:T278	3.38	No	No	0	9	6
249	R:R:A270	R:R:I268	3.25	No	Yes	0	1	3
250	R:R:G280	R:R:H282	3.18	No	No	0	6	6
251	R:R:T297	R:R:V248	3.17	No	No	0	6	7
252	R:R:C438	R:R:L479	3.17	No	No	0	7	6
253	R:R:C189	R:R:N356	3.15	Yes	Yes	2	9	6
254	R:R:C264	R:R:N356	3.15	No	Yes	2	9	6
255	R:R:I212	R:R:S215	3.1	No	No	0	5	3
256	R:R:I306	R:R:S334	3.1	No	No	0	7	5
257	R:R:F256	R:R:Y204	3.09	Yes	No	0	6	4
258	R:R:I352	R:R:T287	3.04	No	No	0	8	7
259	R:R:M291	R:R:T343	3.01	No	Yes	0	7	9
260	R:R:M472	R:R:T470	3.01	No	No	0	1	1
261	R:R:G447	R:R:R446	3	No	No	0	3	6
262	R:R:L429	R:R:V383	2.98	No	Yes	0	7	8
263	R:R:L432	R:R:V383	2.98	No	Yes	0	7	8
264	R:R:L391	R:R:V387	2.98	No	No	0	4	6
265	R:R:I394	R:R:M418	2.92	No	No	0	7	8
266	R:R:G491	R:R:Y245	2.9	No	Yes	0	9	8
267	R:R:P475	R:R:R474	2.88	No	No	0	8	4
268	R:R:K413	R:R:K416	2.87	No	No	0	9	7
269	R:R:I209	R:R:L485	2.85	No	No	0	5	7
270	R:R:I251	R:R:L289	2.85	No	No	0	6	7
271	R:R:I421	R:R:L307	2.85	No	No	0	8	9
272	R:R:I421	R:R:L390	2.85	No	No	0	8	8
273	R:R:L485	R:R:M482	2.83	No	No	0	7	6
274	R:R:L214	R:R:L218	2.77	No	No	0	4	4
275	R:R:A392	R:R:F312	2.77	No	No	0	6	7
276	R:R:D174	R:R:L175	2.71	No	No	0	4	3
277	R:R:R183	R:R:S178	2.64	No	No	0	3	3
278	R:R:R399	R:R:S396	2.64	No	No	0	6	8
279	R:R:F219	R:R:V495	2.62	No	No	0	7	8
280	R:R:D260	R:R:E259	2.6	No	No	0	6	6
281	R:R:S494	R:R:Y241	2.54	No	Yes	0	8	8
282	R:R:I226	R:R:R230	2.51	No	No	0	7	9
283	R:R:F331	R:R:I309	2.51	Yes	No	0	8	6
284	R:R:F374	R:R:I345	2.51	No	No	0	8	4
285	R:R:S473	R:R:W449	2.47	No	Yes	0	3	9
286	R:R:L381	R:R:Y382	2.34	No	Yes	0	4	5
287	R:R:G255	R:R:G359	2.11	No	No	0	8	9
288	R:R:G337	R:R:P339	2.03	No	No	0	6	9
289	R:R:C361	R:R:G354	1.96	No	No	0	9	8
290	R:R:A263	R:R:G354	1.95	No	No	0	7	8
291	R:R:A315	R:R:G393	1.95	No	No	0	8	9
292	R:R:C465	R:R:P466	1.88	No	No	0	9	5
293	R:R:A377	R:R:P378	1.87	No	No	0	4	9
294	R:R:G422	R:R:S425	1.86	No	No	0	7	8
295	R:R:G437	R:R:I436	1.76	No	No	0	5	6
296	R:R:C185	R:R:V182	1.71	No	No	0	9	5
297	R:R:A216	R:R:S215	1.71	No	No	0	8	3
298	R:R:A216	R:R:V495	1.7	No	No	0	8	8
299	R:R:A487	R:R:V435	1.7	No	No	0	5	7
300	R:R:I338	R:R:P339	1.69	No	No	0	4	9
301	R:R:L313	R:R:P317	1.64	No	No	0	8	7
302	R:R:D172	R:R:P173	1.61	No	No	0	4	3
303	R:R:D174	R:R:P173	1.61	No	No	0	4	3
304	R:R:V383	R:R:V387	1.6	Yes	No	0	8	6
305	R:R:P466	R:R:Q455	1.58	No	No	0	5	3
306	R:R:I206	R:R:S210	1.55	No	No	0	7	8
307	R:R:I206	R:R:S358	1.55	No	Yes	0	7	8
308	R:R:I448	R:R:S473	1.55	No	No	0	3	3
309	R:R:L289	R:R:V262	1.49	No	No	0	7	6
310	R:R:L433	R:R:V383	1.49	No	Yes	0	4	8
311	R:R:I454	R:R:I463	1.47	No	No	0	3	5
312	R:R:I268	R:R:K273	1.45	Yes	No	0	3	3
313	R:R:E322	R:R:S321	1.44	No	No	0	9	6
314	R:R:Q468	R:R:V469	1.43	No	No	0	2	1
315	R:R:I394	R:R:N398	1.42	No	No	0	7	6
316	R:R:G320	R:R:W319	1.41	No	No	0	7	8
317	R:R:K327	R:R:L330	1.41	No	No	0	6	6
318	R:R:L222	R:R:L225	1.38	No	No	0	6	5
319	R:R:F331	R:R:K327	1.24	Yes	No	0	8	6
320	R:R:V182	R:R:W164	1.23	No	No	0	5	4
321	R:R:F201	R:R:L477	1.22	No	No	0	6	5
322	R:R:T452	R:R:W449	1.21	No	Yes	0	5	9
323	R:R:Q468	R:R:Y467	1.13	No	No	0	2	1
324	R:R:E168	R:R:Y461	1.12	No	No	0	5	4
325	R:R:F496	R:R:R420	1.07	No	No	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P166	4.8225	4	5	6
2	R:R:Y177	9.09	4	0	6
3	R:R:P187	11.58	4	0	5
4	R:R:C189	5.152	5	2	9
5	R:R:Y193	9.005	4	2	5
6	R:R:Y233	5.856	5	8	9
7	R:R:Y241	8.67	5	3	8
8	R:R:Y245	6.5	6	3	8
9	R:R:M246	5.2175	4	0	5
10	R:R:F252	7.8775	4	4	8
11	R:R:F253	7.2675	4	0	5
12	R:R:F256	5.0625	4	0	6
13	R:R:I268	4.16	4	0	3
14	R:R:L293	5.2325	4	0	6
15	R:R:Y294	6.81	6	1	9
16	R:R:F295	5.3025	4	1	8
17	R:R:W303	10.0267	6	1	9
18	R:R:W304	7.418	5	0	9
19	R:R:F331	3.80833	6	8	8
20	R:R:W336	6.24	6	1	9
21	R:R:T343	3.8825	4	1	9
22	R:R:L346	6.82	4	1	7
23	R:R:D355	7.8925	4	4	9
24	R:R:N356	3.735	4	2	6
25	R:R:S358	3.962	5	4	8
26	R:R:L371	6.6175	4	9	8
27	R:R:Y382	4.83833	6	0	5
28	R:R:V383	2.2625	4	0	8
29	R:R:Y428	8.146	5	3	8
30	R:R:Y439	7.906	5	9	5
31	R:R:W449	7.308	5	0	9
32	R:R:R457	7.6025	4	0	4
33	R:R:W497	7.31	4	7	9
34	R:R:V498	4.2825	4	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P166	R:R:Y461	16.1685	5.56	Yes	No	0	6	4
2	R:R:R457	R:R:Y461	18.1093	7.2	Yes	No	0	4	4
3	R:R:R457	R:R:W453	20.963	9	Yes	No	0	4	5
4	R:R:E450	R:R:W453	22.8884	7.63	No	No	0	6	5
5	R:R:E450	R:R:L180	23.7705	3.98	No	No	0	6	4
6	R:R:F179	R:R:L180	24.7298	18.27	No	No	0	5	4
7	R:R:F179	R:R:P187	25.6102	24.56	No	Yes	0	5	5
8	R:R:P187	R:R:S186	33.1815	3.56	Yes	No	0	5	6
9	R:R:S186	R:R:Y177	19.6441	6.36	No	Yes	0	6	6
10	R:R:S186	R:R:T276	12.8762	9.59	No	No	0	6	5
11	R:R:P187	R:R:V277	14.6405	7.07	Yes	No	0	5	6
12	R:R:P187	R:R:Y366	61.8613	11.13	Yes	No	0	5	5
13	R:R:N356	R:R:V277	13.7892	4.43	Yes	No	0	6	6
14	R:R:E353	R:R:Y366	62.5824	4.49	No	No	0	7	5
15	R:R:E353	R:R:L365	64.0316	5.3	No	No	0	7	6
16	R:R:D355	R:R:L365	64.775	13.57	Yes	No	0	9	6
17	R:R:D355	R:R:S358	45.626	4.42	Yes	Yes	4	9	8
18	R:R:F252	R:R:S358	56.0219	5.28	Yes	Yes	4	8	8
19	R:R:F252	R:R:L293	100	4.87	Yes	Yes	0	8	6
20	R:R:L293	R:R:V248	66.8717	4.47	Yes	No	0	6	7
21	R:R:V248	R:R:Y245	66.488	3.79	No	Yes	0	7	8
22	R:R:Y241	R:R:Y245	35.7731	11.91	Yes	Yes	3	8	8
23	R:R:P493	R:R:Y241	18.6231	5.56	No	Yes	0	8	8
24	R:R:I492	R:R:P493	17.2151	3.39	No	No	0	8	8
25	R:R:I489	R:R:I492	12.167	4.42	No	No	0	5	8
26	R:R:D355	R:R:V360	43.8377	4.38	Yes	No	4	9	7
27	R:R:F252	R:R:V360	44.0484	9.18	Yes	No	4	8	7
28	R:R:I206	R:R:S358	12.7597	1.55	No	Yes	0	7	8
29	R:R:I206	R:R:S210	12.2613	1.55	No	No	0	7	8
30	R:R:I251	R:R:L293	35.0691	4.28	No	Yes	0	6	6
31	R:R:I251	R:R:I292	32.6967	10.3	No	No	0	6	5
32	R:R:I292	R:R:M247	32.2188	4.37	No	No	0	5	5
33	R:R:F424	R:R:Y241	17.0712	13.41	No	Yes	0	9	8
34	R:R:F424	R:R:I238	16.7612	6.28	No	No	0	9	9
35	R:R:I238	R:R:W497	16.1	7.05	No	Yes	0	9	9
36	R:R:G300	R:R:Y245	35.0297	4.35	No	Yes	0	8	8
37	R:R:C244	R:R:G300	34.5569	3.92	No	No	0	9	8
38	R:R:C244	R:R:W336	32.599	3.92	No	Yes	1	9	9
39	R:R:W303	R:R:W336	14.7365	11.25	Yes	Yes	1	9	9
40	R:R:F296	R:R:M247	26.0402	9.95	No	No	0	8	5
41	R:R:F296	R:R:W336	24.3461	5.01	No	Yes	1	8	9
42	R:R:Y245	R:R:Y428	15.819	5.96	Yes	Yes	3	8	8
43	R:R:N265	R:R:T278	11.982	10.24	No	No	0	4	6
44	R:R:F295	R:R:W336	41.4481	7.02	Yes	Yes	1	8	9
45	R:R:F295	R:R:T343	36.0661	3.89	Yes	Yes	1	8	9
46	R:R:T343	R:R:Y294	33.966	4.99	Yes	Yes	1	9	9
47	R:R:M298	R:R:Y294	10.5123	11.97	No	Yes	0	7	9
48	R:R:L346	R:R:Y294	16.2096	5.86	Yes	Yes	1	7	9
49	R:R:W304	R:R:Y428	14.1318	11.58	Yes	Yes	0	9	8
50	R:R:T308	R:R:W304	11.7097	8.49	No	Yes	0	7	9
51	R:R:F417	R:R:W497	11.4527	4.01	No	Yes	0	8	9
52	R:R:D355	R:R:Y484	28.6507	9.2	Yes	No	0	9	8
53	R:R:E442	R:R:W449	10.8361	5.45	No	Yes	0	9	9
54	R:R:E442	R:R:L371	11.5504	3.98	No	Yes	0	9	8
55	R:R:K483	R:R:Y484	26.8281	9.55	No	No	0	8	8
56	R:R:K483	R:R:Y439	21.381	11.94	No	Yes	0	8	5
57	R:R:L371	R:R:Y439	13.1349	12.89	Yes	Yes	9	8	5
58	R:R:I463	R:R:P166	10.2074	3.39	No	Yes	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8JHC

PDB Summary
PDB	8JHC
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD3
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.3
Date	2024-01-17
D.O.I.	10.1038/s41421-023-00627-y

Net Summary
I_min	3.56
Number of Linked Nodes	297
Number of Links	325
Number of Hubs	34
Number of Links mediated by Hubs	140
Number of Communities	9
Number of Nodes involved in Communities	44
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	84684
Length Of Smallest Path	3
Average Path Length	17.2382
Length of Longest Path	37
Minimum Path Strength	1.28
Average Path Strength	6.56131
Maximum Path Strength	21.415
Minimum Path Correlation	0.7
Average Path Correlation	0.93197
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.97
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.5347
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • Wnt receptor activity • G protein-coupled receptor activity • protein binding • binding • PDZ domain binding • protein domain specific binding • Wnt-protein binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • signaling • canonical Wnt signaling pathway • biological regulation • cell communication • cellular process • signal transduction • Wnt signaling pathway
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • signaling • canonical Wnt signaling pathway • biological regulation • cell communication • cellular process • signal transduction • Wnt signaling pathway • developmental process • multicellular organismal process • head development • cell population proliferation • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • cell proliferation in midbrain • midbrain development • anatomical structure development • neural precursor cell proliferation • system development • ear morphogenesis • embryonic organ morphogenesis • ear development • sensory organ development • embryonic morphogenesis • embryo development • anatomical structure morphogenesis • sensory organ morphogenesis • inner ear development • inner ear morphogenesis • animal organ morphogenesis • embryonic organ development • non-canonical Wnt signaling pathway • epithelium development • epidermis development • molting cycle process • hair cycle • tissue development • skin development • skin epidermis development • hair follicle development • molting cycle • hair cycle process • sympathetic nervous system development • ganglion development • autonomic nervous system development • sympathetic ganglion development • cellular developmental process • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • neuron migration • motor neuron migration • cell migration • cell motility • regulation of mitotic cell cycle, embryonic • negative regulation of biological process • negative regulation of cell cycle • mitotic cell cycle • negative regulation of mitotic cell cycle • mitotic cell cycle, embryonic • regulation of mitotic cell cycle • negative regulation of cellular process • negative regulation of mitotic cell cycle, embryonic • cell cycle • regulation of cell cycle • commissural neuron axon guidance • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon guidance • axon development • cell morphogenesis involved in neuron differentiation • neuron projection guidance • neuron development • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of execution phase of apoptosis • regulation of programmed cell death • cell death • regulation of execution phase of apoptosis • execution phase of apoptosis • negative regulation of apoptotic process • apoptotic process • programmed cell death • post-anal tail morphogenesis • response to electrical stimulus • response to abiotic stimulus • embryonic epithelial tube formation • chordate embryonic development • tube formation • epithelial tube formation • tube morphogenesis • primary neural tube formation • embryo development ending in birth or egg hatching • epithelial tube morphogenesis • morphogenesis of embryonic epithelium • neural tube development • tube development • morphogenesis of an epithelium • tissue morphogenesis • neural tube closure • neural tube formation • anatomical structure formation involved in morphogenesis • tube closure • Wnt signaling pathway, planar cell polarity pathway • dopaminergic neuron axon guidance • serotonergic neuron axon guidance • brain morphogenesis • midbrain morphogenesis • neuroblast proliferation • positive regulation of nervous system development • positive regulation of cell population proliferation • regulation of developmental process • positive regulation of biological process • regulation of neuroblast proliferation • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of multicellular organismal process • positive regulation of cellular process • regulation of neural precursor cell proliferation • regulation of multicellular organismal development • positive regulation of cell development • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • positive regulation of multicellular organismal process • positive regulation of neuroblast proliferation • establishment of planar polarity • establishment of tissue polarity • morphogenesis of a polarized epithelium • electron transport chain • metabolic process • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cell surface • filopodium tip • cell projection • actin-based cell projection • filopodium • plasma membrane bounded cell projection • somatodendritic compartment
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cell surface • filopodium tip • cell projection • actin-based cell projection • filopodium • plasma membrane bounded cell projection • somatodendritic compartment • dendrite • dendritic tree • neuron projection • intracellular anatomical structure • cytoplasm • synapse • cell junction • glutamatergic synapse • presynaptic active zone membrane • presynaptic membrane • synaptic membrane • presynapse • presynaptic active zone • cell body • neuronal cell body • axon • lateral plasma membrane • periplasmic space
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NPG1
Sequence	>8JHC_Chain_R W C P R E L K I D P D L G Y S F L H V R D C S P P C P N M Y F R R E E L S F A R Y F I G L I S I I C L S A T L F T F L T F L I D V T R F R Y P E R P I I F Y A V C Y M M V S L I F F I G F L L E D R V A C N A S I P A Q Y K A S T V T Q G S H N K A C T M L F M I L Y F F T M A G S V W W V I L T I T W F L A A V P K W G S E A I E K K A L L F H A S A W G I P G T L T I I L L A M N K I E G D N I S G V C F V G L Y D V D A L R Y F V L A P L C L Y V V V G V S L L L A G I I S L N R D K L V K F M I R I G V F S I L Y L V P L L V V I G C Y F Y E Q A Y R G I W E T T W I Q E R C R E Y H I P C P Y Q V T Q M S R P D L I L F L M K Y L M A L I V G I P S V F W V G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8QW4	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	-	2.9	2024-09-04	doi.org/10.1038/s41467-024-51451-1
	8JHI	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	chim(NtGsXLas-Gs)/β1/γ2	3.2	2024-01-17	10.1038/s41421-023-00627-y

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JHC.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.