psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C165	R:R:P166	3.77	No	Yes	5	9	5
2	R:R:C165	R:R:L169	4.76	No	No	5	9	6
3	R:R:C165	R:R:C185	7.28	No	No	0	9	9
4	R:R:L169	R:R:P166	6.57	No	Yes	5	6	5
5	R:R:P166	R:R:Y461	5.56	Yes	No	0	5	4
6	R:R:K170	R:R:R167	7.43	No	No	6	5	3
7	R:R:K273	R:R:R167	16.09	No	No	6	3	3
8	R:R:K170	R:R:K273	5.75	No	No	6	5	3
9	R:R:D172	R:R:I171	4.2	No	No	0	5	5
10	R:R:I171	R:R:Y177	13.3	No	Yes	0	5	7
11	R:R:D184	R:R:P173	11.27	No	No	0	5	4
12	R:R:H282	R:R:L175	6.43	No	No	0	6	4
13	R:R:S186	R:R:Y177	6.36	No	Yes	0	7	7
14	R:R:N265	R:R:Y177	5.81	No	Yes	0	5	7
15	R:R:H282	R:R:Y177	10.89	No	Yes	0	6	7
16	R:R:F179	R:R:L180	18.27	No	No	0	4	4
17	R:R:F179	R:R:P187	24.56	No	Yes	0	4	5
18	R:R:E450	R:R:L180	3.98	No	No	0	5	4
19	R:R:D184	R:R:R183	9.53	No	No	0	5	4
20	R:R:P187	R:R:S186	3.56	Yes	No	0	5	7
21	R:R:S186	R:R:T276	9.59	No	No	0	7	6
22	R:R:P187	R:R:V277	7.07	Yes	No	0	5	5
23	R:R:P187	R:R:Y366	11.13	Yes	No	0	5	5
24	R:R:P188	R:R:W453	5.4	No	No	0	6	5
25	R:R:C189	R:R:P190	3.77	Yes	No	2	9	3
26	R:R:C189	R:R:D260	4.67	Yes	No	2	9	6
27	R:R:C189	R:R:C264	7.28	Yes	No	2	9	9
28	R:R:C189	R:R:S275	6.89	Yes	No	2	9	4
29	R:R:P190	R:R:S275	3.56	No	No	2	3	4
30	R:R:N191	R:R:R457	7.23	No	Yes	0	5	3
31	R:R:M192	R:R:Y193	8.38	No	Yes	2	6	5
32	R:R:F194	R:R:M192	3.73	No	No	2	6	6
33	R:R:M192	R:R:N356	4.21	No	Yes	2	6	7
34	R:R:F194	R:R:Y193	12.38	No	Yes	2	6	5
35	R:R:P475	R:R:Y193	11.13	No	Yes	0	8	5
36	R:R:F480	R:R:Y193	4.13	No	Yes	0	6	5
37	R:R:F194	R:R:L199	6.09	No	No	0	6	7
38	R:R:E198	R:R:R195	36.05	No	No	0	6	5
39	R:R:A202	R:R:L481	4.73	No	No	0	6	7
40	R:R:F256	R:R:R203	5.34	Yes	No	0	5	7
41	R:R:E259	R:R:R203	20.93	No	No	0	6	7
42	R:R:L208	R:R:Y204	22.27	No	No	0	4	3
43	R:R:F205	R:R:L481	3.65	No	No	0	7	7
44	R:R:F205	R:R:L485	4.87	No	No	0	7	5
45	R:R:G207	R:R:S210	3.71	No	No	0	4	7
46	R:R:F256	R:R:G207	7.53	Yes	No	0	5	4
47	R:R:I209	R:R:I489	4.42	No	No	0	6	5
48	R:R:F253	R:R:S210	3.96	Yes	No	0	5	7
49	R:R:F253	R:R:I211	3.77	Yes	No	0	5	4
50	R:R:C213	R:R:I492	4.91	No	No	0	7	7
51	R:R:L214	R:R:S249	6.01	No	No	0	4	8
52	R:R:L214	R:R:L250	4.15	No	No	0	4	4
53	R:R:M246	R:R:T217	4.52	Yes	No	0	4	8
54	R:R:F219	R:R:T223	6.49	No	No	7	7	9
55	R:R:F219	R:R:V498	3.93	No	Yes	7	7	6
56	R:R:S494	R:R:T220	6.4	No	No	0	8	8
57	R:R:T220	R:R:V498	4.76	No	Yes	0	8	6
58	R:R:F221	R:R:F224	4.29	No	No	0	5	7
59	R:R:F221	R:R:L225	4.87	No	No	0	5	5
60	R:R:F221	R:R:M246	7.46	No	Yes	0	5	4
61	R:R:T223	R:R:V498	4.76	No	Yes	7	9	6
62	R:R:F224	R:R:R236	6.41	No	No	0	7	9
63	R:R:F224	R:R:I239	17.58	No	No	0	7	7
64	R:R:D227	R:R:T229	4.34	No	No	0	8	4
65	R:R:D227	R:R:R230	16.68	No	No	0	8	9
66	R:R:F231	R:R:R230	4.28	No	No	0	8	9
67	R:R:E235	R:R:F231	13.99	No	No	8	9	8
68	R:R:F231	R:R:W497	4.01	No	Yes	8	8	9
69	R:R:R232	R:R:S321	10.54	No	No	0	6	6
70	R:R:E325	R:R:R232	5.82	No	No	0	7	6
71	R:R:R236	R:R:Y233	6.17	No	Yes	0	9	9
72	R:R:I324	R:R:Y233	3.63	No	Yes	9	8	9
73	R:R:E325	R:R:Y233	8.98	No	Yes	0	7	9
74	R:R:A328	R:R:Y233	5.34	No	Yes	0	7	9
75	R:R:F331	R:R:Y233	5.16	Yes	Yes	9	8	9
76	R:R:P234	R:R:S321	3.56	No	No	0	9	6
77	R:R:E235	R:R:W497	14.17	No	Yes	8	9	9
78	R:R:P237	R:R:W303	5.4	No	Yes	0	8	9
79	R:R:F424	R:R:I238	6.28	No	No	0	8	8
80	R:R:I238	R:R:W497	7.05	No	Yes	0	8	9
81	R:R:F240	R:R:I239	3.77	No	No	0	7	7
82	R:R:F240	R:R:W303	15.03	No	Yes	1	7	9
83	R:R:F240	R:R:H332	6.79	No	No	1	7	9
84	R:R:Y241	R:R:Y245	11.91	Yes	Yes	3	7	7
85	R:R:F424	R:R:Y241	13.41	No	Yes	0	8	7
86	R:R:Y241	R:R:Y428	9.93	Yes	Yes	3	7	7
87	R:R:P493	R:R:Y241	5.56	No	Yes	0	7	7
88	R:R:M246	R:R:V243	4.56	Yes	No	0	4	4
89	R:R:C244	R:R:F296	5.59	No	No	1	9	8
90	R:R:C244	R:R:G300	3.92	No	No	0	9	8
91	R:R:C244	R:R:W336	3.92	No	Yes	1	9	9
92	R:R:V248	R:R:Y245	3.79	No	Yes	0	7	7
93	R:R:G300	R:R:Y245	4.35	No	Yes	0	8	7
94	R:R:Y245	R:R:Y428	5.96	Yes	Yes	3	7	7
95	R:R:V490	R:R:Y245	10.09	No	Yes	3	6	7
96	R:R:M246	R:R:M247	4.33	Yes	No	0	4	5
97	R:R:I292	R:R:M247	4.37	No	No	0	5	5
98	R:R:F296	R:R:M247	9.95	No	No	0	8	5
99	R:R:L293	R:R:V248	4.47	Yes	No	0	7	7
100	R:R:I254	R:R:L250	4.28	No	No	0	5	4
101	R:R:I251	R:R:I292	10.3	No	No	0	6	5
102	R:R:I251	R:R:L293	4.28	No	Yes	0	6	7
103	R:R:F252	R:R:L293	4.87	Yes	Yes	0	7	7
104	R:R:F252	R:R:S358	5.28	Yes	Yes	4	7	8
105	R:R:F252	R:R:V360	9.18	Yes	No	4	7	7
106	R:R:F252	R:R:L488	12.18	Yes	No	0	7	8
107	R:R:F253	R:R:F256	4.29	Yes	Yes	0	5	5
108	R:R:F253	R:R:L257	17.05	Yes	No	0	5	3
109	R:R:L258	R:R:R261	4.86	No	No	0	4	3
110	R:R:L258	R:R:V262	5.96	No	No	0	4	5
111	R:R:C264	R:R:D260	6.22	No	No	2	9	6
112	R:R:N265	R:R:T276	4.39	No	No	0	5	6
113	R:R:N265	R:R:T278	10.24	No	No	0	5	5
114	R:R:S267	R:R:S275	4.89	No	No	0	4	4
115	R:R:I268	R:R:P269	5.08	Yes	No	0	3	4
116	R:R:I268	R:R:Q271	6.86	Yes	No	0	3	1
117	R:R:N356	R:R:V277	4.43	Yes	No	0	7	5
118	R:R:K284	R:R:T278	4.5	No	No	0	5	5
119	R:R:E353	R:R:Q279	7.65	No	No	0	8	8
120	R:R:G280	R:R:N350	5.09	No	No	0	7	5
121	R:R:C286	R:R:C361	7.28	No	No	0	9	9
122	R:R:F290	R:R:Y294	7.22	No	Yes	0	9	9
123	R:R:F290	R:R:L347	3.65	No	No	0	9	8
124	R:R:F290	R:R:I352	8.79	No	No	0	9	8
125	R:R:F362	R:R:L293	7.31	No	Yes	0	7	7
126	R:R:M298	R:R:Y294	11.97	No	Yes	0	7	9
127	R:R:L342	R:R:Y294	7.03	No	Yes	0	7	9
128	R:R:T343	R:R:Y294	4.99	Yes	Yes	1	8	9
129	R:R:L346	R:R:Y294	5.86	Yes	Yes	1	6	9
130	R:R:V363	R:R:Y294	3.79	No	Yes	1	8	9
131	R:R:F295	R:R:W336	7.02	Yes	Yes	1	8	9
132	R:R:F295	R:R:P339	5.78	Yes	No	0	8	8
133	R:R:F295	R:R:G340	4.52	Yes	No	1	8	8
134	R:R:F295	R:R:T343	3.89	Yes	Yes	1	8	8
135	R:R:F296	R:R:W336	5.01	No	Yes	1	8	9
136	R:R:L379	R:R:M298	4.24	No	No	0	6	7
137	R:R:M298	R:R:Y382	4.79	No	Yes	0	7	5
138	R:R:A299	R:R:W336	3.89	No	Yes	0	9	9
139	R:R:S301	R:R:Y382	7.63	No	Yes	0	6	5
140	R:R:V302	R:R:Y382	6.31	No	Yes	0	5	5
141	R:R:I306	R:R:W303	9.4	No	Yes	0	6	9
142	R:R:H332	R:R:W303	7.41	No	Yes	1	9	9
143	R:R:A335	R:R:W303	11.67	No	Yes	0	8	9
144	R:R:W303	R:R:W336	11.25	Yes	Yes	1	9	9
145	R:R:T308	R:R:W304	8.49	No	Yes	0	7	8
146	R:R:F424	R:R:W304	4.01	No	Yes	0	8	8
147	R:R:S425	R:R:W304	6.18	No	Yes	0	8	8
148	R:R:W304	R:R:Y428	11.58	Yes	Yes	0	8	7
149	R:R:L429	R:R:W304	6.83	No	Yes	0	5	8
150	R:R:V305	R:R:Y382	3.79	No	Yes	0	8	5
151	R:R:F331	R:R:I306	6.28	Yes	No	0	8	6
152	R:R:L307	R:R:T310	4.42	No	No	0	9	7
153	R:R:G386	R:R:T308	5.46	No	No	0	8	7
154	R:R:L389	R:R:T308	4.42	No	No	0	7	7
155	R:R:F331	R:R:T310	3.89	Yes	No	0	8	7
156	R:R:G393	R:R:W311	5.63	No	No	0	8	9
157	R:R:I394	R:R:W311	7.05	No	No	0	7	9
158	R:R:F417	R:R:W311	8.02	No	No	0	8	9
159	R:R:F312	R:R:V316	9.18	No	No	0	7	6
160	R:R:F312	R:R:L389	6.09	No	No	0	7	7
161	R:R:L313	R:R:W319	10.25	No	No	0	8	8
162	R:R:S396	R:R:V316	4.85	No	No	0	7	6
163	R:R:A323	R:R:W319	9.08	No	No	0	8	8
164	R:R:F331	R:R:I324	3.77	Yes	No	9	8	8
165	R:R:H332	R:R:W336	6.35	No	Yes	1	9	9
166	R:R:G340	R:R:T343	3.64	No	Yes	1	8	8
167	R:R:K351	R:R:L346	4.23	No	Yes	0	6	6
168	R:R:L346	R:R:V363	7.45	Yes	No	1	6	8
169	R:R:F374	R:R:L346	9.74	No	Yes	0	8	6
170	R:R:K351	R:R:M349	8.64	No	No	0	6	5
171	R:R:D369	R:R:K351	6.91	No	No	0	1	6
172	R:R:E353	R:R:L365	5.3	No	No	0	8	7
173	R:R:E353	R:R:Y366	4.49	No	No	0	8	5
174	R:R:D355	R:R:S358	4.42	Yes	Yes	4	9	8
175	R:R:D355	R:R:V360	4.38	Yes	No	4	9	7
176	R:R:D355	R:R:L365	13.57	Yes	No	0	9	7
177	R:R:D355	R:R:Y484	9.2	Yes	No	0	9	7
178	R:R:I357	R:R:Y484	3.63	No	No	0	7	7
179	R:R:G359	R:R:S358	3.71	No	Yes	0	9	8
180	R:R:S358	R:R:V360	4.85	Yes	No	4	8	7
181	R:R:G364	R:R:L371	5.13	No	Yes	0	9	8
182	R:R:D367	R:R:D369	13.31	No	No	0	7	1
183	R:R:A370	R:R:D367	4.63	No	No	0	6	7
184	R:R:Q443	R:R:V368	4.3	No	No	0	6	3
185	R:R:R446	R:R:V368	7.85	No	No	0	5	3
186	R:R:D369	R:R:Y373	9.2	No	No	0	1	1
187	R:R:L371	R:R:V375	4.47	Yes	No	10	8	7
188	R:R:L371	R:R:Y439	12.89	Yes	Yes	10	8	4
189	R:R:E442	R:R:L371	3.98	No	Yes	0	8	8
190	R:R:R372	R:R:Y373	7.2	No	No	0	5	1
191	R:R:Q443	R:R:R372	15.19	No	No	0	6	5
192	R:R:F374	R:R:Y373	5.16	No	No	0	8	1
193	R:R:V375	R:R:Y439	5.05	No	Yes	10	7	4
194	R:R:I436	R:R:L376	4.28	No	No	0	5	7
195	R:R:L376	R:R:Y439	5.86	No	Yes	0	7	4
196	R:R:F440	R:R:L376	14.61	No	No	0	4	7
197	R:R:P378	R:R:Y382	4.17	No	Yes	0	9	5
198	R:R:C380	R:R:I436	4.91	No	No	0	3	5
199	R:R:G386	R:R:V385	3.68	No	No	0	8	4
200	R:R:L390	R:R:S425	6.01	No	No	0	8	8
201	R:R:I395	R:R:R399	5.01	No	No	0	4	7
202	R:R:L397	R:R:L414	4.15	No	No	0	8	8
203	R:R:L397	R:R:M418	5.65	No	No	0	8	8
204	R:R:D412	R:R:V415	5.84	No	No	0	5	7
205	R:R:M418	R:R:V415	4.56	No	No	0	8	7
206	R:R:K416	R:R:R420	8.66	No	No	0	6	9
207	R:R:F417	R:R:R420	5.34	No	No	0	8	9
208	R:R:F417	R:R:W497	4.01	No	Yes	0	8	9
209	R:R:F496	R:R:V423	7.87	No	No	0	6	5
210	R:R:L432	R:R:Y428	8.21	No	Yes	0	6	7
211	R:R:V490	R:R:Y428	5.05	No	Yes	3	6	7
212	R:R:M486	R:R:P431	6.71	No	No	0	8	8
213	R:R:M486	R:R:V434	6.09	No	No	0	8	4
214	R:R:V435	R:R:Y439	3.79	No	Yes	0	6	4
215	R:R:C438	R:R:K483	6.47	No	No	0	7	8
216	R:R:K483	R:R:Y439	11.94	No	Yes	0	8	4
217	R:R:L479	R:R:Y441	8.21	No	No	0	5	8
218	R:R:E442	R:R:W449	5.45	No	Yes	0	8	9
219	R:R:A444	R:R:Y445	8.01	No	No	0	3	4
220	R:R:W449	R:R:Y445	5.79	Yes	No	0	9	4
221	R:R:P475	R:R:W449	21.62	No	Yes	0	8	9
222	R:R:E450	R:R:W453	7.63	No	No	0	5	5
223	R:R:R457	R:R:W453	9	Yes	No	0	3	5
224	R:R:I454	R:R:P466	5.08	No	No	0	3	5
225	R:R:P466	R:R:Q455	12.63	No	No	0	5	3
226	R:R:E456	R:R:R474	10.47	No	No	0	4	4
227	R:R:E460	R:R:R457	6.98	No	Yes	0	3	3
228	R:R:R457	R:R:Y461	7.2	Yes	No	0	3	4
229	R:R:C458	R:R:C465	7.28	No	No	0	9	9
230	R:R:H462	R:R:R459	9.03	No	No	0	4	4
231	R:R:Q468	R:R:Y467	13.53	No	No	0	1	1
232	R:R:D476	R:R:I478	5.6	No	No	0	5	4
233	R:R:D476	R:R:L479	12.21	No	No	0	5	5
234	R:R:L477	R:R:L481	8.3	No	No	0	6	7
235	R:R:K483	R:R:Y484	9.55	No	No	0	8	7
236	R:R:I489	R:R:I492	4.42	No	No	0	5	7
237	R:R:G499	R:R:V498	3.68	No	Yes	0	5	6
238	R:R:P317	R:R:V316	3.53	No	No	0	6	6
239	R:R:P431	R:R:V430	3.53	No	No	0	8	5
240	R:R:E197	R:R:R196	3.49	No	No	0	3	2
241	R:R:C213	R:R:S249	3.44	No	No	0	7	8
242	R:R:A242	R:R:S494	3.42	No	No	0	8	8
243	R:R:I463	R:R:P166	3.39	No	Yes	0	5	5
244	R:R:G176	R:R:N350	3.39	No	No	0	4	5
245	R:R:I489	R:R:P431	3.39	No	No	0	5	8
246	R:R:I463	R:R:P464	3.39	No	No	0	5	4
247	R:R:C286	R:R:T278	3.38	No	No	0	9	5
248	R:R:L427	R:R:P493	3.28	No	No	0	7	7
249	R:R:A270	R:R:I268	3.25	No	Yes	0	2	3
250	R:R:G280	R:R:H282	3.18	No	No	0	7	6
251	R:R:T297	R:R:V248	3.17	No	No	0	6	7
252	R:R:C438	R:R:L479	3.17	No	No	0	7	5
253	R:R:C189	R:R:N356	3.15	Yes	Yes	2	9	7
254	R:R:C264	R:R:N356	3.15	No	Yes	2	9	7
255	R:R:I212	R:R:S215	3.1	No	No	0	4	3
256	R:R:I306	R:R:S334	3.1	No	No	0	6	5
257	R:R:C465	R:R:Q455	3.05	No	No	0	9	3
258	R:R:I352	R:R:T287	3.04	No	No	0	8	7
259	R:R:M291	R:R:T343	3.01	No	Yes	0	7	8
260	R:R:G447	R:R:R446	3	No	No	0	3	5
261	R:R:L429	R:R:V383	2.98	No	Yes	0	5	7
262	R:R:L432	R:R:V383	2.98	No	Yes	0	6	7
263	R:R:L391	R:R:V387	2.98	No	No	0	4	4
264	R:R:I394	R:R:M418	2.92	No	No	0	7	8
265	R:R:G491	R:R:Y245	2.9	No	Yes	0	9	7
266	R:R:P475	R:R:R474	2.88	No	No	0	8	4
267	R:R:K413	R:R:K416	2.87	No	No	0	8	6
268	R:R:I209	R:R:L485	2.85	No	No	0	6	5
269	R:R:I209	R:R:L488	2.85	No	No	0	6	8
270	R:R:I251	R:R:L289	2.85	No	No	0	6	7
271	R:R:I421	R:R:L307	2.85	No	No	0	8	9
272	R:R:I421	R:R:L390	2.85	No	No	0	8	8
273	R:R:Q455	R:R:T470	2.83	No	No	0	3	1
274	R:R:L485	R:R:M482	2.83	No	No	0	5	6
275	R:R:L214	R:R:L218	2.77	No	No	0	4	5
276	R:R:A392	R:R:F312	2.77	No	No	0	5	7
277	R:R:D174	R:R:L175	2.71	No	No	0	3	4
278	R:R:E198	R:R:L477	2.65	No	No	0	6	6
279	R:R:R183	R:R:S178	2.64	No	No	0	4	4
280	R:R:R196	R:R:S200	2.64	No	No	0	2	2
281	R:R:R399	R:R:S396	2.64	No	No	0	7	7
282	R:R:F219	R:R:V495	2.62	No	No	0	7	7
283	R:R:D260	R:R:E259	2.6	No	No	0	6	6
284	R:R:S494	R:R:Y241	2.54	No	Yes	0	8	7
285	R:R:I226	R:R:R230	2.51	No	No	0	7	9
286	R:R:F331	R:R:I309	2.51	Yes	No	0	8	5
287	R:R:F374	R:R:I345	2.51	No	No	0	8	4
288	R:R:S473	R:R:W449	2.47	No	Yes	0	3	9
289	R:R:L381	R:R:Y382	2.34	No	Yes	0	4	5
290	R:R:E168	R:R:R167	2.33	No	No	0	5	3
291	R:R:G255	R:R:G359	2.11	No	No	0	9	9
292	R:R:F256	R:R:Y204	2.06	Yes	No	0	5	3
293	R:R:G337	R:R:P339	2.03	No	No	0	5	8
294	R:R:C361	R:R:G354	1.96	No	No	0	9	8
295	R:R:A263	R:R:G354	1.95	No	No	0	7	8
296	R:R:A315	R:R:G393	1.95	No	No	0	8	8
297	R:R:A377	R:R:P378	1.87	No	No	0	4	9
298	R:R:G422	R:R:S425	1.86	No	No	0	6	8
299	R:R:G437	R:R:I436	1.76	No	No	0	5	5
300	R:R:C185	R:R:V182	1.71	No	No	0	9	5
301	R:R:A216	R:R:S215	1.71	No	No	0	7	3
302	R:R:A216	R:R:V495	1.7	No	No	0	7	7
303	R:R:A487	R:R:V435	1.7	No	No	0	5	6
304	R:R:I338	R:R:P339	1.69	No	No	0	4	8
305	R:R:L313	R:R:P317	1.64	No	No	0	8	6
306	R:R:D172	R:R:P173	1.61	No	No	0	5	4
307	R:R:D174	R:R:P173	1.61	No	No	0	3	4
308	R:R:V383	R:R:V387	1.6	Yes	No	0	7	4
309	R:R:E168	R:R:P166	1.57	No	Yes	0	5	5
310	R:R:I206	R:R:S210	1.55	No	No	0	7	7
311	R:R:I206	R:R:S358	1.55	No	Yes	0	7	8
312	R:R:I448	R:R:S473	1.55	No	No	0	1	3
313	R:R:M472	R:R:T470	1.51	No	No	0	1	1
314	R:R:L289	R:R:V262	1.49	No	No	0	7	5
315	R:R:L433	R:R:V383	1.49	No	Yes	0	4	7
316	R:R:I454	R:R:I463	1.47	No	No	0	3	5
317	R:R:I268	R:R:K273	1.45	Yes	No	0	3	3
318	R:R:E322	R:R:S321	1.44	No	No	0	9	6
319	R:R:Q468	R:R:V469	1.43	No	No	0	1	1
320	R:R:Q471	R:R:V469	1.43	No	No	0	1	1
321	R:R:I394	R:R:N398	1.42	No	No	0	7	5
322	R:R:G320	R:R:W319	1.41	No	No	0	7	8
323	R:R:K327	R:R:L330	1.41	No	No	0	6	6
324	R:R:E456	R:R:T452	1.41	No	No	0	4	5
325	R:R:L222	R:R:L225	1.38	No	No	0	5	5
326	R:R:I448	R:R:Q471	1.37	No	No	0	1	1
327	R:R:F331	R:R:K327	1.24	Yes	No	0	8	6
328	R:R:V182	R:R:W164	1.23	No	No	0	5	3
329	R:R:F201	R:R:L477	1.22	No	No	0	6	6
330	R:R:L199	R:R:R196	1.21	No	No	0	7	2
331	R:R:E460	R:R:R459	1.16	No	No	0	3	4
332	R:R:F496	R:R:R420	1.07	No	No	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P166	4.172	5	5	5
2	R:R:Y177	9.09	4	0	7
3	R:R:P187	11.58	4	0	5
4	R:R:C189	5.152	5	2	9
5	R:R:Y193	9.005	4	2	5
6	R:R:Y233	5.856	5	9	9
7	R:R:Y241	8.67	5	3	7
8	R:R:Y245	6.5	6	3	7
9	R:R:M246	5.2175	4	0	4
10	R:R:F252	7.8775	4	4	7
11	R:R:F253	7.2675	4	0	5
12	R:R:F256	4.805	4	0	5
13	R:R:I268	4.16	4	0	3
14	R:R:L293	5.2325	4	0	7
15	R:R:Y294	6.81	6	1	9
16	R:R:F295	5.3025	4	1	8
17	R:R:W303	10.0267	6	1	9
18	R:R:W304	7.418	5	0	8
19	R:R:F331	3.80833	6	9	8
20	R:R:W336	6.24	6	1	9
21	R:R:T343	3.8825	4	1	8
22	R:R:L346	6.82	4	1	6
23	R:R:D355	7.8925	4	4	9
24	R:R:N356	3.735	4	2	7
25	R:R:S358	3.962	5	4	8
26	R:R:L371	6.6175	4	10	8
27	R:R:Y382	4.83833	6	0	5
28	R:R:V383	2.2625	4	0	7
29	R:R:Y428	8.146	5	3	7
30	R:R:Y439	7.906	5	10	4
31	R:R:W449	8.8325	4	0	9
32	R:R:R457	7.6025	4	0	3
33	R:R:W497	7.31	4	8	9
34	R:R:V498	4.2825	4	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P166	R:R:Y461	22.309	5.56	Yes	No	0	5	4
2	R:R:R457	R:R:Y461	23.2396	7.2	Yes	No	0	3	4
3	R:R:R457	R:R:W453	27.7855	9	Yes	No	0	3	5
4	R:R:E450	R:R:W453	29.6023	7.63	No	No	0	5	5
5	R:R:E450	R:R:L180	30.4359	3.98	No	No	0	5	4
6	R:R:F179	R:R:L180	31.3401	18.27	No	No	0	4	4
7	R:R:F179	R:R:P187	32.1688	24.56	No	Yes	0	4	5
8	R:R:P187	R:R:S186	27.7346	3.56	Yes	No	0	5	7
9	R:R:S186	R:R:Y177	19.1474	6.36	No	Yes	0	7	7
10	R:R:P187	R:R:V277	17.2287	7.07	Yes	No	0	5	5
11	R:R:P187	R:R:Y366	63.9478	11.13	Yes	No	0	5	5
12	R:R:N356	R:R:V277	16.4198	4.43	Yes	No	0	7	5
13	R:R:M192	R:R:N356	10.1294	4.21	No	Yes	2	6	7
14	R:R:E353	R:R:Y366	64.6203	4.49	No	No	0	8	5
15	R:R:E353	R:R:L365	65.9816	5.3	No	No	0	8	7
16	R:R:D355	R:R:L365	66.6853	13.57	Yes	No	0	9	7
17	R:R:D355	R:R:S358	47.1187	4.42	Yes	Yes	4	9	8
18	R:R:F252	R:R:S358	56.9439	5.28	Yes	Yes	4	7	8
19	R:R:F252	R:R:L488	18.1116	12.18	Yes	No	0	7	8
20	R:R:I209	R:R:L488	17.3602	2.85	No	No	0	6	8
21	R:R:D355	R:R:V360	45.3151	4.38	Yes	No	4	9	7
22	R:R:F252	R:R:V360	45.5009	9.18	Yes	No	4	7	7
23	R:R:I206	R:R:S358	12.2585	1.55	No	Yes	0	7	8
24	R:R:I206	R:R:S210	11.7867	1.55	No	No	0	7	7
25	R:R:F252	R:R:L293	100	4.87	Yes	Yes	0	7	7
26	R:R:I251	R:R:L293	38.5463	4.28	No	Yes	0	6	7
27	R:R:I251	R:R:I292	36.1294	10.3	No	No	0	6	5
28	R:R:I292	R:R:M247	35.6428	4.37	No	No	0	5	5
29	R:R:L293	R:R:V248	62.6556	4.47	Yes	No	0	7	7
30	R:R:V248	R:R:Y245	62.0801	3.79	No	Yes	0	7	7
31	R:R:Y241	R:R:Y245	23.838	11.91	Yes	Yes	3	7	7
32	R:R:F424	R:R:Y241	16.1978	13.41	No	Yes	0	8	7
33	R:R:F424	R:R:I238	16.7453	6.28	No	No	0	8	8
34	R:R:I238	R:R:W497	16.0827	7.05	No	Yes	0	8	9
35	R:R:G300	R:R:Y245	34.2831	4.35	No	Yes	0	8	7
36	R:R:C244	R:R:G300	33.8014	3.92	No	No	0	9	8
37	R:R:C244	R:R:W336	32.2723	3.92	No	Yes	1	9	9
38	R:R:W303	R:R:W336	14.8776	11.25	Yes	Yes	1	9	9
39	R:R:I306	R:R:W303	10.0028	9.4	No	Yes	0	6	9
40	R:R:F296	R:R:M247	28.1949	9.95	No	No	0	8	5
41	R:R:F296	R:R:W336	26.8435	5.01	No	Yes	1	8	9
42	R:R:Y245	R:R:Y428	17.0741	5.96	Yes	Yes	3	7	7
43	R:R:N265	R:R:T278	11.688	10.24	No	No	0	5	5
44	R:R:F295	R:R:W336	43.2501	7.02	Yes	Yes	1	8	9
45	R:R:F295	R:R:T343	37.6157	3.89	Yes	Yes	1	8	8
46	R:R:T343	R:R:Y294	35.4126	4.99	Yes	Yes	1	8	9
47	R:R:M298	R:R:Y294	10.9334	11.97	No	Yes	0	7	9
48	R:R:L346	R:R:Y294	16.8703	5.86	Yes	Yes	1	6	9
49	R:R:W304	R:R:Y428	14.1904	11.58	Yes	Yes	0	8	7
50	R:R:T308	R:R:W304	11.0879	8.49	No	Yes	0	7	8
51	R:R:F417	R:R:W497	11.4365	4.01	No	Yes	0	8	9
52	R:R:D355	R:R:Y484	29.7799	9.2	Yes	No	0	9	7
53	R:R:E442	R:R:W449	12.8652	5.45	No	Yes	0	8	9
54	R:R:E442	R:R:L371	13.5311	3.98	No	Yes	0	8	8
55	R:R:K483	R:R:Y484	28.0453	9.55	No	No	0	8	7
56	R:R:K483	R:R:Y439	22.8664	11.94	No	Yes	0	8	4
57	R:R:L371	R:R:Y439	15.0157	12.89	Yes	Yes	10	8	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8JHC

PDB Summary
PDB	8JHC
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD3
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.3
Date	2024-01-17
D.O.I.	10.1038/s41421-023-00627-y

Net Summary
I_min	3.56
Number of Linked Nodes	302
Number of Links	332
Number of Hubs	34
Number of Links mediated by Hubs	140
Number of Communities	10
Number of Nodes involved in Communities	47
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	90188
Length Of Smallest Path	3
Average Path Length	17.5057
Length of Longest Path	37
Minimum Path Strength	1.325
Average Path Strength	6.68181
Maximum Path Strength	21.415
Minimum Path Correlation	0.7
Average Path Correlation	0.93289
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.957
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9238
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NPG1
Sequence	>8JHC_Chain_R W C P R E L K I D P D L G Y S F L H V R D C S P P C P N M Y F R R E E L S F A R Y F I G L I S I I C L S A T L F T F L T F L I D V T R F R Y P E R P I I F Y A V C Y M M V S L I F F I G F L L E D R V A C N A S I P A Q Y K A S T V T Q G S H N K A C T M L F M I L Y F F T M A G S V W W V I L T I T W F L A A V P K W G S E A I E K K A L L F H A S A W G I P G T L T I I L L A M N K I E G D N I S G V C F V G L Y D V D A L R Y F V L A P L C L Y V V V G V S L L L A G I I S L N R D K L V K F M I R I G V F S I L Y L V P L L V V I G C Y F Y E Q A Y R G I W E T T W I Q E R C R E Y H I P C P Y Q V T Q M S R P D L I L F L M K Y L M A L I V G I P S V F W V G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHI	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	chim(NtGsXLas-Gs)/&β;1/&γ;2	3.2	2024-01-17	10.1038/s41421-023-00627-y

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JHC.zip

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