psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C165	R:R:P166	3.77	No	Yes	5	9	6
2	R:R:C165	R:R:L169	4.76	No	No	5	9	6
3	R:R:C165	R:R:C185	7.28	No	No	0	9	9
4	R:R:L169	R:R:P166	6.57	No	Yes	5	6	6
5	R:R:P166	R:R:Y461	5.56	Yes	No	0	6	4
6	R:R:D172	R:R:I171	4.2	No	No	0	4	4
7	R:R:I171	R:R:Y177	13.3	No	Yes	0	4	6
8	R:R:D184	R:R:P173	11.27	No	No	0	6	3
9	R:R:H282	R:R:L175	6.43	No	No	0	6	3
10	R:R:S186	R:R:Y177	6.36	No	Yes	0	6	6
11	R:R:N265	R:R:Y177	5.81	No	Yes	0	4	6
12	R:R:H282	R:R:Y177	10.89	No	Yes	0	6	6
13	R:R:F179	R:R:L180	18.27	No	No	0	5	4
14	R:R:F179	R:R:P187	24.56	No	Yes	0	5	5
15	R:R:E450	R:R:L180	3.98	No	No	0	6	4
16	R:R:D184	R:R:R183	9.53	No	No	0	6	3
17	R:R:P187	R:R:S186	3.56	Yes	No	0	5	6
18	R:R:S186	R:R:T276	9.59	No	No	0	6	5
19	R:R:P187	R:R:V277	7.07	Yes	No	0	5	6
20	R:R:P187	R:R:Y366	11.13	Yes	No	0	5	5
21	R:R:P188	R:R:W453	5.4	No	No	0	5	5
22	R:R:C189	R:R:P190	3.77	Yes	No	2	9	3
23	R:R:C189	R:R:D260	4.67	Yes	No	2	9	6
24	R:R:C189	R:R:C264	7.28	Yes	No	2	9	9
25	R:R:C189	R:R:S275	6.89	Yes	No	2	9	3
26	R:R:P190	R:R:S275	3.56	No	No	2	3	3
27	R:R:N191	R:R:R457	7.23	No	Yes	0	4	4
28	R:R:M192	R:R:Y193	8.38	No	Yes	2	7	5
29	R:R:F194	R:R:M192	3.73	No	No	2	6	7
30	R:R:M192	R:R:N356	4.21	No	Yes	2	7	6
31	R:R:F194	R:R:Y193	12.38	No	Yes	2	6	5
32	R:R:P475	R:R:Y193	11.13	No	Yes	0	8	5
33	R:R:F480	R:R:Y193	4.13	No	Yes	0	6	5
34	R:R:F194	R:R:L199	6.09	No	No	0	6	6
35	R:R:E198	R:R:R195	6.98	No	No	0	7	4
36	R:R:E198	R:R:L477	17.23	No	No	0	7	5
37	R:R:A202	R:R:L481	4.73	No	No	0	7	8
38	R:R:F256	R:R:R203	5.34	Yes	No	0	6	7
39	R:R:E259	R:R:R203	15.12	No	No	0	6	7
40	R:R:L208	R:R:Y204	5.86	No	No	0	3	4
41	R:R:F205	R:R:L481	3.65	No	No	0	7	8
42	R:R:F205	R:R:L485	4.87	No	No	0	7	7
43	R:R:G207	R:R:S210	3.71	No	No	0	6	8
44	R:R:F256	R:R:G207	7.53	Yes	No	0	6	6
45	R:R:I209	R:R:I489	4.42	No	No	0	5	5
46	R:R:F253	R:R:S210	3.96	Yes	No	0	5	8
47	R:R:F253	R:R:I211	3.77	Yes	No	0	5	3
48	R:R:C213	R:R:I492	4.91	No	No	0	8	8
49	R:R:L214	R:R:S249	6.01	No	No	0	4	8
50	R:R:L214	R:R:L250	4.15	No	No	0	4	4
51	R:R:M246	R:R:T217	4.52	Yes	No	0	5	8
52	R:R:F219	R:R:T223	6.49	No	No	6	7	9
53	R:R:F219	R:R:V498	3.93	No	Yes	6	7	7
54	R:R:S494	R:R:T220	6.4	No	No	0	8	8
55	R:R:T220	R:R:V498	4.76	No	Yes	0	8	7
56	R:R:F221	R:R:F224	4.29	No	No	0	7	9
57	R:R:F221	R:R:L225	4.87	No	No	0	7	5
58	R:R:F221	R:R:M246	7.46	No	Yes	0	7	5
59	R:R:T223	R:R:V498	4.76	No	Yes	6	9	7
60	R:R:F224	R:R:R236	6.41	No	No	0	9	9
61	R:R:F224	R:R:I239	17.58	No	No	0	9	8
62	R:R:D227	R:R:T229	4.34	No	No	0	8	4
63	R:R:D227	R:R:R230	16.68	No	No	0	8	9
64	R:R:F231	R:R:R230	4.28	No	No	0	9	9
65	R:R:E235	R:R:F231	13.99	No	No	7	9	9
66	R:R:F231	R:R:W497	4.01	No	Yes	7	9	9
67	R:R:R232	R:R:S321	10.54	No	No	0	6	6
68	R:R:E325	R:R:R232	5.82	No	No	0	7	6
69	R:R:R236	R:R:Y233	6.17	No	Yes	0	9	9
70	R:R:I324	R:R:Y233	3.63	No	Yes	8	9	9
71	R:R:E325	R:R:Y233	8.98	No	Yes	0	7	9
72	R:R:A328	R:R:Y233	5.34	No	Yes	0	8	9
73	R:R:F331	R:R:Y233	5.16	Yes	Yes	8	8	9
74	R:R:P234	R:R:S321	3.56	No	No	0	9	6
75	R:R:E235	R:R:W497	14.17	No	Yes	7	9	9
76	R:R:P237	R:R:W303	5.4	No	Yes	0	8	9
77	R:R:F424	R:R:I238	6.28	No	No	0	9	9
78	R:R:I238	R:R:W497	7.05	No	Yes	0	9	9
79	R:R:F240	R:R:I239	3.77	No	No	0	8	8
80	R:R:F240	R:R:W303	15.03	No	Yes	1	8	9
81	R:R:F240	R:R:H332	6.79	No	No	1	8	9
82	R:R:Y241	R:R:Y245	11.91	Yes	Yes	3	8	8
83	R:R:F424	R:R:Y241	13.41	No	Yes	0	9	8
84	R:R:Y241	R:R:Y428	9.93	Yes	Yes	3	8	8
85	R:R:P493	R:R:Y241	5.56	No	Yes	0	8	8
86	R:R:M246	R:R:V243	4.56	Yes	No	0	5	5
87	R:R:C244	R:R:F296	5.59	No	No	1	9	8
88	R:R:C244	R:R:G300	3.92	No	No	0	9	8
89	R:R:C244	R:R:W336	3.92	No	Yes	1	9	9
90	R:R:V248	R:R:Y245	3.79	No	Yes	0	7	8
91	R:R:G300	R:R:Y245	4.35	No	Yes	0	8	8
92	R:R:Y245	R:R:Y428	5.96	Yes	Yes	3	8	8
93	R:R:V490	R:R:Y245	10.09	No	Yes	3	8	8
94	R:R:M246	R:R:M247	4.33	Yes	No	0	5	5
95	R:R:I292	R:R:M247	4.37	No	No	0	5	5
96	R:R:F296	R:R:M247	9.95	No	No	0	8	5
97	R:R:L293	R:R:V248	4.47	Yes	No	0	6	7
98	R:R:I254	R:R:L250	4.28	No	No	0	4	4
99	R:R:I251	R:R:I292	10.3	No	No	0	6	5
100	R:R:I251	R:R:L293	4.28	No	Yes	0	6	6
101	R:R:F252	R:R:L293	4.87	Yes	Yes	0	8	6
102	R:R:F252	R:R:S358	5.28	Yes	Yes	4	8	8
103	R:R:F252	R:R:V360	9.18	Yes	No	4	8	7
104	R:R:F252	R:R:L488	12.18	Yes	No	0	8	8
105	R:R:F253	R:R:F256	4.29	Yes	Yes	0	5	6
106	R:R:F253	R:R:L257	17.05	Yes	No	0	5	4
107	R:R:L258	R:R:R261	4.86	No	No	0	4	3
108	R:R:L258	R:R:V262	5.96	No	No	0	4	6
109	R:R:C264	R:R:D260	6.22	No	No	2	9	6
110	R:R:N265	R:R:T276	4.39	No	No	0	4	5
111	R:R:N265	R:R:T278	10.24	No	No	0	4	6
112	R:R:S267	R:R:S275	4.89	No	No	0	5	3
113	R:R:I268	R:R:P269	5.08	Yes	No	0	3	2
114	R:R:I268	R:R:Q271	6.86	Yes	No	0	3	3
115	R:R:K273	R:R:T276	4.5	No	No	0	3	5
116	R:R:N356	R:R:V277	4.43	Yes	No	0	6	6
117	R:R:K284	R:R:T278	4.5	No	No	0	6	6
118	R:R:E353	R:R:Q279	7.65	No	No	0	7	7
119	R:R:G280	R:R:N350	5.09	No	No	0	6	6
120	R:R:C286	R:R:C361	7.28	No	No	0	9	9
121	R:R:F290	R:R:Y294	7.22	No	Yes	0	9	9
122	R:R:F290	R:R:L347	3.65	No	No	0	9	8
123	R:R:F290	R:R:I352	8.79	No	No	0	9	8
124	R:R:F362	R:R:L293	7.31	No	Yes	0	7	6
125	R:R:M298	R:R:Y294	11.97	No	Yes	0	7	9
126	R:R:L342	R:R:Y294	7.03	No	Yes	0	7	9
127	R:R:T343	R:R:Y294	4.99	Yes	Yes	1	9	9
128	R:R:L346	R:R:Y294	5.86	Yes	Yes	1	7	9
129	R:R:V363	R:R:Y294	3.79	No	Yes	1	9	9
130	R:R:F295	R:R:W336	7.02	Yes	Yes	1	8	9
131	R:R:F295	R:R:P339	5.78	Yes	No	0	8	9
132	R:R:F295	R:R:G340	4.52	Yes	No	1	8	7
133	R:R:F295	R:R:T343	3.89	Yes	Yes	1	8	9
134	R:R:F296	R:R:W336	5.01	No	Yes	1	8	9
135	R:R:L379	R:R:M298	4.24	No	No	0	7	7
136	R:R:M298	R:R:Y382	4.79	No	Yes	0	7	5
137	R:R:A299	R:R:W336	3.89	No	Yes	0	9	9
138	R:R:S301	R:R:Y382	7.63	No	Yes	0	6	5
139	R:R:V302	R:R:Y382	6.31	No	Yes	0	5	5
140	R:R:I306	R:R:W303	9.4	No	Yes	0	7	9
141	R:R:H332	R:R:W303	7.41	No	Yes	1	9	9
142	R:R:A335	R:R:W303	11.67	No	Yes	0	9	9
143	R:R:W303	R:R:W336	11.25	Yes	Yes	1	9	9
144	R:R:T308	R:R:W304	8.49	No	Yes	0	7	9
145	R:R:F424	R:R:W304	4.01	No	Yes	0	9	9
146	R:R:S425	R:R:W304	6.18	No	Yes	0	8	9
147	R:R:W304	R:R:Y428	11.58	Yes	Yes	0	9	8
148	R:R:L429	R:R:W304	6.83	No	Yes	0	7	9
149	R:R:V305	R:R:Y382	3.79	No	Yes	0	8	5
150	R:R:F331	R:R:I306	6.28	Yes	No	0	8	7
151	R:R:L307	R:R:T310	4.42	No	No	0	9	8
152	R:R:G386	R:R:T308	5.46	No	No	0	9	7
153	R:R:L389	R:R:T308	4.42	No	No	0	8	7
154	R:R:F331	R:R:T310	3.89	Yes	No	0	8	8
155	R:R:G393	R:R:W311	5.63	No	No	0	9	9
156	R:R:I394	R:R:W311	7.05	No	No	0	7	9
157	R:R:F417	R:R:W311	8.02	No	No	0	8	9
158	R:R:F312	R:R:V316	9.18	No	No	0	7	7
159	R:R:F312	R:R:L389	6.09	No	No	0	7	8
160	R:R:L313	R:R:W319	10.25	No	No	0	8	8
161	R:R:S396	R:R:V316	4.85	No	No	0	8	7
162	R:R:A323	R:R:W319	9.08	No	No	0	8	8
163	R:R:F331	R:R:I324	3.77	Yes	No	8	8	9
164	R:R:H332	R:R:W336	6.35	No	Yes	1	9	9
165	R:R:G340	R:R:T343	3.64	No	Yes	1	7	9
166	R:R:K351	R:R:L346	4.23	No	Yes	0	6	7
167	R:R:L346	R:R:V363	7.45	Yes	No	1	7	9
168	R:R:F374	R:R:L346	9.74	No	Yes	0	8	7
169	R:R:K351	R:R:M349	8.64	No	No	0	6	4
170	R:R:D369	R:R:K351	6.91	No	No	0	2	6
171	R:R:E353	R:R:L365	5.3	No	No	0	7	6
172	R:R:E353	R:R:Y366	4.49	No	No	0	7	5
173	R:R:D355	R:R:S358	4.42	Yes	Yes	4	9	8
174	R:R:D355	R:R:V360	4.38	Yes	No	4	9	7
175	R:R:D355	R:R:L365	13.57	Yes	No	0	9	6
176	R:R:D355	R:R:Y484	9.2	Yes	No	0	9	8
177	R:R:I357	R:R:Y484	3.63	No	No	0	8	8
178	R:R:G359	R:R:S358	3.71	No	Yes	0	9	8
179	R:R:S358	R:R:V360	4.85	Yes	No	4	8	7
180	R:R:G364	R:R:L371	5.13	No	Yes	0	8	8
181	R:R:D367	R:R:D369	13.31	No	No	0	6	2
182	R:R:A370	R:R:D367	4.63	No	No	0	6	6
183	R:R:Q443	R:R:V368	4.3	No	No	0	5	3
184	R:R:R446	R:R:V368	7.85	No	No	0	6	3
185	R:R:D369	R:R:Y373	9.2	No	No	0	2	2
186	R:R:L371	R:R:V375	4.47	Yes	No	9	8	7
187	R:R:L371	R:R:Y439	12.89	Yes	Yes	9	8	5
188	R:R:E442	R:R:L371	3.98	No	Yes	0	9	8
189	R:R:R372	R:R:Y373	7.2	No	No	0	6	2
190	R:R:Q443	R:R:R372	15.19	No	No	0	5	6
191	R:R:F374	R:R:Y373	5.16	No	No	0	8	2
192	R:R:V375	R:R:Y439	5.05	No	Yes	9	7	5
193	R:R:I436	R:R:L376	4.28	No	No	0	6	6
194	R:R:L376	R:R:Y439	5.86	No	Yes	0	6	5
195	R:R:F440	R:R:L376	14.61	No	No	0	4	6
196	R:R:P378	R:R:Y382	4.17	No	Yes	0	9	5
197	R:R:C380	R:R:I436	4.91	No	No	0	3	6
198	R:R:G386	R:R:V385	3.68	No	No	0	9	4
199	R:R:L390	R:R:S425	6.01	No	No	0	8	8
200	R:R:I395	R:R:R399	5.01	No	No	0	5	6
201	R:R:L397	R:R:L414	4.15	No	No	0	8	9
202	R:R:L397	R:R:M418	5.65	No	No	0	8	8
203	R:R:D412	R:R:V415	5.84	No	No	0	4	8
204	R:R:M418	R:R:V415	4.56	No	No	0	8	8
205	R:R:K416	R:R:R420	8.66	No	No	0	7	9
206	R:R:F417	R:R:R420	5.34	No	No	0	8	9
207	R:R:F417	R:R:W497	4.01	No	Yes	0	8	9
208	R:R:F496	R:R:V423	7.87	No	No	0	6	6
209	R:R:L427	R:R:P493	4.93	No	No	0	7	8
210	R:R:L432	R:R:Y428	8.21	No	Yes	0	7	8
211	R:R:V490	R:R:Y428	5.05	No	Yes	3	8	8
212	R:R:M486	R:R:P431	6.71	No	No	0	7	9
213	R:R:M486	R:R:V434	6.09	No	No	0	7	5
214	R:R:V435	R:R:Y439	3.79	No	Yes	0	7	5
215	R:R:C438	R:R:K483	6.47	No	No	0	7	8
216	R:R:K483	R:R:Y439	11.94	No	Yes	0	8	5
217	R:R:L479	R:R:Y441	8.21	No	No	0	6	9
218	R:R:E442	R:R:W449	5.45	No	Yes	0	9	9
219	R:R:A444	R:R:Y445	8.01	No	No	0	3	4
220	R:R:W449	R:R:Y445	5.79	Yes	No	0	9	4
221	R:R:I448	R:R:Q471	12.35	No	No	0	3	2
222	R:R:P475	R:R:W449	21.62	No	Yes	0	8	9
223	R:R:E450	R:R:W453	7.63	No	No	0	6	5
224	R:R:R457	R:R:W453	9	Yes	No	0	4	5
225	R:R:I454	R:R:P466	5.08	No	No	0	3	5
226	R:R:Q455	R:R:T470	4.25	No	No	0	3	1
227	R:R:E456	R:R:R474	4.65	No	No	0	4	4
228	R:R:E460	R:R:R457	6.98	No	Yes	0	3	4
229	R:R:R457	R:R:Y461	7.2	Yes	No	0	4	4
230	R:R:C458	R:R:C465	7.28	No	No	0	9	9
231	R:R:C465	R:R:R459	4.18	No	No	0	9	4
232	R:R:D476	R:R:I478	5.6	No	No	0	5	5
233	R:R:D476	R:R:L479	12.21	No	No	0	5	6
234	R:R:L477	R:R:L481	8.3	No	No	0	5	8
235	R:R:K483	R:R:Y484	9.55	No	No	0	8	8
236	R:R:I489	R:R:I492	4.42	No	No	0	5	8
237	R:R:G499	R:R:V498	3.68	No	Yes	0	7	7
238	R:R:P317	R:R:V316	3.53	No	No	0	7	7
239	R:R:P431	R:R:V430	3.53	No	No	0	9	5
240	R:R:E197	R:R:R195	3.49	No	No	0	4	4
241	R:R:C213	R:R:S249	3.44	No	No	0	8	8
242	R:R:A242	R:R:S494	3.42	No	No	0	8	8
243	R:R:I463	R:R:P166	3.39	No	Yes	0	5	6
244	R:R:G176	R:R:N350	3.39	No	No	0	2	6
245	R:R:I489	R:R:P431	3.39	No	No	0	5	9
246	R:R:I463	R:R:P464	3.39	No	No	0	5	5
247	R:R:I492	R:R:P493	3.39	No	No	0	8	8
248	R:R:C286	R:R:T278	3.38	No	No	0	9	6
249	R:R:A270	R:R:I268	3.25	No	Yes	0	1	3
250	R:R:G280	R:R:H282	3.18	No	No	0	6	6
251	R:R:T297	R:R:V248	3.17	No	No	0	6	7
252	R:R:C438	R:R:L479	3.17	No	No	0	7	6
253	R:R:C189	R:R:N356	3.15	Yes	Yes	2	9	6
254	R:R:C264	R:R:N356	3.15	No	Yes	2	9	6
255	R:R:I212	R:R:S215	3.1	No	No	0	5	3
256	R:R:I306	R:R:S334	3.1	No	No	0	7	5
257	R:R:F256	R:R:Y204	3.09	Yes	No	0	6	4
258	R:R:I352	R:R:T287	3.04	No	No	0	8	7
259	R:R:M291	R:R:T343	3.01	No	Yes	0	7	9
260	R:R:M472	R:R:T470	3.01	No	No	0	1	1
261	R:R:G447	R:R:R446	3	No	No	0	3	6
262	R:R:L429	R:R:V383	2.98	No	Yes	0	7	8
263	R:R:L432	R:R:V383	2.98	No	Yes	0	7	8
264	R:R:L391	R:R:V387	2.98	No	No	0	4	6
265	R:R:I394	R:R:M418	2.92	No	No	0	7	8
266	R:R:G491	R:R:Y245	2.9	No	Yes	0	9	8
267	R:R:P475	R:R:R474	2.88	No	No	0	8	4
268	R:R:K413	R:R:K416	2.87	No	No	0	9	7
269	R:R:I209	R:R:L485	2.85	No	No	0	5	7
270	R:R:I251	R:R:L289	2.85	No	No	0	6	7
271	R:R:I421	R:R:L307	2.85	No	No	0	8	9
272	R:R:I421	R:R:L390	2.85	No	No	0	8	8
273	R:R:L485	R:R:M482	2.83	No	No	0	7	6
274	R:R:L214	R:R:L218	2.77	No	No	0	4	4
275	R:R:A392	R:R:F312	2.77	No	No	0	6	7
276	R:R:D174	R:R:L175	2.71	No	No	0	4	3
277	R:R:R183	R:R:S178	2.64	No	No	0	3	3
278	R:R:R399	R:R:S396	2.64	No	No	0	6	8
279	R:R:F219	R:R:V495	2.62	No	No	0	7	8
280	R:R:D260	R:R:E259	2.6	No	No	0	6	6
281	R:R:S494	R:R:Y241	2.54	No	Yes	0	8	8
282	R:R:I226	R:R:R230	2.51	No	No	0	7	9
283	R:R:F331	R:R:I309	2.51	Yes	No	0	8	6
284	R:R:F374	R:R:I345	2.51	No	No	0	8	4
285	R:R:S473	R:R:W449	2.47	No	Yes	0	3	9
286	R:R:L381	R:R:Y382	2.34	No	Yes	0	4	5
287	R:R:G255	R:R:G359	2.11	No	No	0	8	9
288	R:R:G337	R:R:P339	2.03	No	No	0	6	9
289	R:R:C361	R:R:G354	1.96	No	No	0	9	8
290	R:R:A263	R:R:G354	1.95	No	No	0	7	8
291	R:R:A315	R:R:G393	1.95	No	No	0	8	9
292	R:R:C465	R:R:P466	1.88	No	No	0	9	5
293	R:R:A377	R:R:P378	1.87	No	No	0	4	9
294	R:R:G422	R:R:S425	1.86	No	No	0	7	8
295	R:R:G437	R:R:I436	1.76	No	No	0	5	6
296	R:R:C185	R:R:V182	1.71	No	No	0	9	5
297	R:R:A216	R:R:S215	1.71	No	No	0	8	3
298	R:R:A216	R:R:V495	1.7	No	No	0	8	8
299	R:R:A487	R:R:V435	1.7	No	No	0	5	7
300	R:R:I338	R:R:P339	1.69	No	No	0	4	9
301	R:R:L313	R:R:P317	1.64	No	No	0	8	7
302	R:R:D172	R:R:P173	1.61	No	No	0	4	3
303	R:R:D174	R:R:P173	1.61	No	No	0	4	3
304	R:R:V383	R:R:V387	1.6	Yes	No	0	8	6
305	R:R:P466	R:R:Q455	1.58	No	No	0	5	3
306	R:R:I206	R:R:S210	1.55	No	No	0	7	8
307	R:R:I206	R:R:S358	1.55	No	Yes	0	7	8
308	R:R:I448	R:R:S473	1.55	No	No	0	3	3
309	R:R:L289	R:R:V262	1.49	No	No	0	7	6
310	R:R:L433	R:R:V383	1.49	No	Yes	0	4	8
311	R:R:I454	R:R:I463	1.47	No	No	0	3	5
312	R:R:I268	R:R:K273	1.45	Yes	No	0	3	3
313	R:R:E322	R:R:S321	1.44	No	No	0	9	6
314	R:R:Q468	R:R:V469	1.43	No	No	0	2	1
315	R:R:I394	R:R:N398	1.42	No	No	0	7	6
316	R:R:G320	R:R:W319	1.41	No	No	0	7	8
317	R:R:K327	R:R:L330	1.41	No	No	0	6	6
318	R:R:L222	R:R:L225	1.38	No	No	0	6	5
319	R:R:F331	R:R:K327	1.24	Yes	No	0	8	6
320	R:R:V182	R:R:W164	1.23	No	No	0	5	4
321	R:R:F201	R:R:L477	1.22	No	No	0	6	5
322	R:R:T452	R:R:W449	1.21	No	Yes	0	5	9
323	R:R:Q468	R:R:Y467	1.13	No	No	0	2	1
324	R:R:E168	R:R:Y461	1.12	No	No	0	5	4
325	R:R:F496	R:R:R420	1.07	No	No	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P166	4.8225	4	5	6
2	R:R:Y177	9.09	4	0	6
3	R:R:P187	11.58	4	0	5
4	R:R:C189	5.152	5	2	9
5	R:R:Y193	9.005	4	2	5
6	R:R:Y233	5.856	5	8	9
7	R:R:Y241	8.67	5	3	8
8	R:R:Y245	6.5	6	3	8
9	R:R:M246	5.2175	4	0	5
10	R:R:F252	7.8775	4	4	8
11	R:R:F253	7.2675	4	0	5
12	R:R:F256	5.0625	4	0	6
13	R:R:I268	4.16	4	0	3
14	R:R:L293	5.2325	4	0	6
15	R:R:Y294	6.81	6	1	9
16	R:R:F295	5.3025	4	1	8
17	R:R:W303	10.0267	6	1	9
18	R:R:W304	7.418	5	0	9
19	R:R:F331	3.80833	6	8	8
20	R:R:W336	6.24	6	1	9
21	R:R:T343	3.8825	4	1	9
22	R:R:L346	6.82	4	1	7
23	R:R:D355	7.8925	4	4	9
24	R:R:N356	3.735	4	2	6
25	R:R:S358	3.962	5	4	8
26	R:R:L371	6.6175	4	9	8
27	R:R:Y382	4.83833	6	0	5
28	R:R:V383	2.2625	4	0	8
29	R:R:Y428	8.146	5	3	8
30	R:R:Y439	7.906	5	9	5
31	R:R:W449	7.308	5	0	9
32	R:R:R457	7.6025	4	0	4
33	R:R:W497	7.31	4	7	9
34	R:R:V498	4.2825	4	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P166	R:R:Y461	16.1685	5.56	Yes	No	0	6	4
2	R:R:R457	R:R:Y461	18.1093	7.2	Yes	No	0	4	4
3	R:R:R457	R:R:W453	20.963	9	Yes	No	0	4	5
4	R:R:E450	R:R:W453	22.8884	7.63	No	No	0	6	5
5	R:R:E450	R:R:L180	23.7705	3.98	No	No	0	6	4
6	R:R:F179	R:R:L180	24.7298	18.27	No	No	0	5	4
7	R:R:F179	R:R:P187	25.6102	24.56	No	Yes	0	5	5
8	R:R:P187	R:R:S186	33.1815	3.56	Yes	No	0	5	6
9	R:R:S186	R:R:Y177	19.6441	6.36	No	Yes	0	6	6
10	R:R:S186	R:R:T276	12.8762	9.59	No	No	0	6	5
11	R:R:P187	R:R:V277	14.6405	7.07	Yes	No	0	5	6
12	R:R:P187	R:R:Y366	61.8613	11.13	Yes	No	0	5	5
13	R:R:N356	R:R:V277	13.7892	4.43	Yes	No	0	6	6
14	R:R:E353	R:R:Y366	62.5824	4.49	No	No	0	7	5
15	R:R:E353	R:R:L365	64.0316	5.3	No	No	0	7	6
16	R:R:D355	R:R:L365	64.775	13.57	Yes	No	0	9	6
17	R:R:D355	R:R:S358	45.626	4.42	Yes	Yes	4	9	8
18	R:R:F252	R:R:S358	56.0219	5.28	Yes	Yes	4	8	8
19	R:R:F252	R:R:L293	100	4.87	Yes	Yes	0	8	6
20	R:R:L293	R:R:V248	66.8717	4.47	Yes	No	0	6	7
21	R:R:V248	R:R:Y245	66.488	3.79	No	Yes	0	7	8
22	R:R:Y241	R:R:Y245	35.7731	11.91	Yes	Yes	3	8	8
23	R:R:P493	R:R:Y241	18.6231	5.56	No	Yes	0	8	8
24	R:R:I492	R:R:P493	17.2151	3.39	No	No	0	8	8
25	R:R:I489	R:R:I492	12.167	4.42	No	No	0	5	8
26	R:R:D355	R:R:V360	43.8377	4.38	Yes	No	4	9	7
27	R:R:F252	R:R:V360	44.0484	9.18	Yes	No	4	8	7
28	R:R:I206	R:R:S358	12.7597	1.55	No	Yes	0	7	8
29	R:R:I206	R:R:S210	12.2613	1.55	No	No	0	7	8
30	R:R:I251	R:R:L293	35.0691	4.28	No	Yes	0	6	6
31	R:R:I251	R:R:I292	32.6967	10.3	No	No	0	6	5
32	R:R:I292	R:R:M247	32.2188	4.37	No	No	0	5	5
33	R:R:F424	R:R:Y241	17.0712	13.41	No	Yes	0	9	8
34	R:R:F424	R:R:I238	16.7612	6.28	No	No	0	9	9
35	R:R:I238	R:R:W497	16.1	7.05	No	Yes	0	9	9
36	R:R:G300	R:R:Y245	35.0297	4.35	No	Yes	0	8	8
37	R:R:C244	R:R:G300	34.5569	3.92	No	No	0	9	8
38	R:R:C244	R:R:W336	32.599	3.92	No	Yes	1	9	9
39	R:R:W303	R:R:W336	14.7365	11.25	Yes	Yes	1	9	9
40	R:R:F296	R:R:M247	26.0402	9.95	No	No	0	8	5
41	R:R:F296	R:R:W336	24.3461	5.01	No	Yes	1	8	9
42	R:R:Y245	R:R:Y428	15.819	5.96	Yes	Yes	3	8	8
43	R:R:N265	R:R:T278	11.982	10.24	No	No	0	4	6
44	R:R:F295	R:R:W336	41.4481	7.02	Yes	Yes	1	8	9
45	R:R:F295	R:R:T343	36.0661	3.89	Yes	Yes	1	8	9
46	R:R:T343	R:R:Y294	33.966	4.99	Yes	Yes	1	9	9
47	R:R:M298	R:R:Y294	10.5123	11.97	No	Yes	0	7	9
48	R:R:L346	R:R:Y294	16.2096	5.86	Yes	Yes	1	7	9
49	R:R:W304	R:R:Y428	14.1318	11.58	Yes	Yes	0	9	8
50	R:R:T308	R:R:W304	11.7097	8.49	No	Yes	0	7	9
51	R:R:F417	R:R:W497	11.4527	4.01	No	Yes	0	8	9
52	R:R:D355	R:R:Y484	28.6507	9.2	Yes	No	0	9	8
53	R:R:E442	R:R:W449	10.8361	5.45	No	Yes	0	9	9
54	R:R:E442	R:R:L371	11.5504	3.98	No	Yes	0	9	8
55	R:R:K483	R:R:Y484	26.8281	9.55	No	No	0	8	8
56	R:R:K483	R:R:Y439	21.381	11.94	No	Yes	0	8	5
57	R:R:L371	R:R:Y439	13.1349	12.89	Yes	Yes	9	8	5
58	R:R:I463	R:R:P166	10.2074	3.39	No	Yes	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8JHC

PDB Summary
PDB	8JHC
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD3
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.3
Date	2024-01-17
D.O.I.	doi.org/10.1038/s41421-023-00627-y

Net Summary
I_min	3.56
Number of Linked Nodes	297
Number of Links	325
Number of Hubs	34
Number of Links mediated by Hubs	140
Number of Communities	9
Number of Nodes involved in Communities	44
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	84684
Length Of Smallest Path	3
Average Path Length	17.2382
Length of Longest Path	37
Minimum Path Strength	1.28
Average Path Strength	6.56131
Maximum Path Strength	21.415
Minimum Path Correlation	0.7
Average Path Correlation	0.93197
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.97
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.5347
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NPG1
Sequence	>8JHC_Chain_R W C P R E L K I D P D L G Y S F L H V R D C S P P C P N M Y F R R E E L S F A R Y F I G L I S I I C L S A T L F T F L T F L I D V T R F R Y P E R P I I F Y A V C Y M M V S L I F F I G F L L E D R V A C N A S I P A Q Y K A S T V T Q G S H N K A C T M L F M I L Y F F T M A G S V W W V I L T I T W F L A A V P K W G S E A I E K K A L L F H A S A W G I P G T L T I I L L A M N K I E G D N I S G V C F V G L Y D V D A L R Y F V L A P L C L Y V V V G V S L L L A G I I S L N R D K L V K F M I R I G V F S I L Y L V P L L V V I G C Y F Y E Q A Y R G I W E T T W I Q E R C R E Y H I P C P Y Q V T Q M S R P D L I L F L M K Y L M A L I V G I P S V F W V G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHI	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	chim(NtGsXLas-Gs)/β1/γ2	3.2	2024-01-17	doi.org/10.1038/s41421-023-00627-y
	8JHI (No Gprot)	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-		3.2	2024-01-17	doi.org/10.1038/s41421-023-00627-y
	8QW4	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	-	2.9	2024-09-04	doi.org/10.1038/s41467-024-51451-1

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JHC.zip

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