psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C165	R:R:C185	7.28	No	No	0	9	9
2	R:R:P166	R:R:S186	5.34	No	No	0	6	6
3	R:R:R167	R:R:Y177	21.61	No	No	0	3	6
4	R:R:R167	R:R:S186	7.91	No	No	0	3	6
5	R:R:R167	R:R:T276	6.47	No	No	0	3	5
6	R:R:H282	R:R:K170	9.17	No	No	0	6	5
7	R:R:G176	R:R:L175	3.42	No	No	0	2	3
8	R:R:Q279	R:R:Y177	13.53	Yes	No	1	7	6
9	R:R:E353	R:R:Y177	3.37	Yes	No	1	7	6
10	R:R:F179	R:R:L180	10.96	No	No	1	5	4
11	R:R:F179	R:R:P187	7.22	No	Yes	1	5	5
12	R:R:F179	R:R:Y366	6.19	No	Yes	1	5	5
13	R:R:L180	R:R:P187	3.28	No	Yes	1	4	5
14	R:R:E450	R:R:H181	4.92	No	No	0	6	4
15	R:R:S186	R:R:T278	6.4	No	No	0	6	6
16	R:R:P187	R:R:Y366	5.56	Yes	Yes	1	5	5
17	R:R:C189	R:R:C264	5.46	No	No	0	9	9
18	R:R:M192	R:R:Y193	3.59	No	Yes	0	7	5
19	R:R:M192	R:R:N356	4.21	No	No	0	7	6
20	R:R:F194	R:R:Y193	3.09	Yes	Yes	0	6	5
21	R:R:Y193	R:R:Y366	5.96	Yes	Yes	0	5	5
22	R:R:R446	R:R:Y193	10.29	No	Yes	0	6	5
23	R:R:W449	R:R:Y193	38.58	Yes	Yes	0	9	5
24	R:R:F194	R:R:M472	9.95	Yes	Yes	0	6	1
25	R:R:D476	R:R:F194	3.58	No	Yes	0	5	6
26	R:R:F194	R:R:F480	12.86	Yes	No	0	6	6
27	R:R:E197	R:R:R195	12.79	No	No	0	4	4
28	R:R:E198	R:R:R195	12.79	No	No	0	7	4
29	R:R:D476	R:R:E198	3.9	No	No	0	5	7
30	R:R:E198	R:R:L477	5.3	No	No	0	7	5
31	R:R:I357	R:R:L199	5.71	No	No	0	8	6
32	R:R:F201	R:R:S200	5.28	No	No	0	6	3
33	R:R:R203	R:R:Y204	9.26	No	No	0	7	4
34	R:R:E259	R:R:R203	3.49	No	No	0	6	7
35	R:R:F205	R:R:I209	13.82	No	No	0	7	5
36	R:R:F205	R:R:L481	8.53	No	No	0	7	8
37	R:R:G207	R:R:S210	3.71	No	No	0	6	8
38	R:R:F256	R:R:G207	4.52	No	No	0	6	6
39	R:R:I209	R:R:L485	5.71	No	No	0	5	7
40	R:R:L488	R:R:S210	4.5	Yes	No	0	8	8
41	R:R:I211	R:R:L214	4.28	No	No	0	3	4
42	R:R:F253	R:R:I211	11.3	No	No	0	5	3
43	R:R:L214	R:R:S249	9.01	No	No	0	4	8
44	R:R:F219	R:R:T223	7.78	No	No	0	7	9
45	R:R:F224	R:R:T220	5.19	No	No	0	9	8
46	R:R:S494	R:R:T220	9.59	No	No	0	8	8
47	R:R:T220	R:R:V498	3.17	No	No	0	8	7
48	R:R:F221	R:R:L225	12.18	No	No	0	7	5
49	R:R:F221	R:R:V243	5.24	No	No	0	7	5
50	R:R:F224	R:R:T223	3.89	No	No	0	9	9
51	R:R:F224	R:R:I239	17.58	No	No	0	9	8
52	R:R:F231	R:R:R230	3.21	No	No	0	9	9
53	R:R:F231	R:R:Y233	18.57	No	No	0	9	9
54	R:R:S321	R:R:Y233	5.09	No	No	0	6	9
55	R:R:E325	R:R:Y233	10.1	No	No	0	7	9
56	R:R:P234	R:R:S321	3.56	No	No	0	9	6
57	R:R:E235	R:R:W497	9.81	No	Yes	0	9	9
58	R:R:E235	R:R:K501	8.1	No	No	0	9	5
59	R:R:F240	R:R:R236	3.21	No	No	0	8	9
60	R:R:A328	R:R:R236	4.15	No	No	0	8	9
61	R:R:P237	R:R:W303	5.4	No	Yes	0	8	9
62	R:R:L307	R:R:P237	11.49	No	No	0	9	8
63	R:R:P237	R:R:T310	3.5	No	No	0	8	8
64	R:R:F424	R:R:I238	3.77	Yes	No	0	9	9
65	R:R:F240	R:R:W303	22.05	No	Yes	5	8	9
66	R:R:F240	R:R:H332	9.05	No	No	5	8	9
67	R:R:Y241	R:R:Y245	9.93	No	No	0	8	8
68	R:R:Y241	R:R:Y428	8.94	No	Yes	0	8	8
69	R:R:G491	R:R:Y241	4.35	No	No	0	9	8
70	R:R:C244	R:R:F296	4.19	No	No	0	9	8
71	R:R:C244	R:R:G300	3.92	No	No	0	9	8
72	R:R:G300	R:R:Y245	5.79	No	No	0	8	8
73	R:R:V490	R:R:Y245	11.36	Yes	No	0	8	8
74	R:R:F296	R:R:M247	12.44	No	No	0	8	5
75	R:R:L293	R:R:V248	4.47	Yes	No	0	6	7
76	R:R:T297	R:R:V248	3.17	No	No	0	6	7
77	R:R:I251	R:R:I292	4.42	No	No	0	6	5
78	R:R:I251	R:R:L293	7.14	No	Yes	0	6	6
79	R:R:F252	R:R:L293	7.31	No	Yes	0	8	6
80	R:R:F252	R:R:Y484	4.13	No	No	0	8	8
81	R:R:F252	R:R:L488	3.65	No	Yes	0	8	8
82	R:R:F253	R:R:L257	8.53	No	No	0	5	4
83	R:R:I254	R:R:L257	4.28	No	No	0	4	4
84	R:R:D260	R:R:L258	6.79	No	No	0	6	4
85	R:R:I357	R:R:R261	3.76	No	No	0	8	3
86	R:R:A263	R:R:D355	4.63	No	No	0	7	9
87	R:R:A285	R:R:N265	4.69	No	No	0	5	4
88	R:R:G280	R:R:T276	5.46	No	No	0	6	5
89	R:R:N283	R:R:T276	5.85	No	No	0	7	5
90	R:R:C286	R:R:Q279	4.58	No	Yes	0	9	7
91	R:R:E353	R:R:Q279	11.47	Yes	Yes	1	7	7
92	R:R:G354	R:R:Q279	6.58	No	Yes	1	8	7
93	R:R:I352	R:R:S281	3.1	Yes	No	0	8	6
94	R:R:C286	R:R:C361	7.28	No	No	0	9	9
95	R:R:L289	R:R:V360	5.96	No	No	0	7	7
96	R:R:F290	R:R:Y294	7.22	Yes	Yes	0	9	9
97	R:R:F290	R:R:L346	7.31	Yes	No	0	9	7
98	R:R:F290	R:R:I352	12.56	Yes	Yes	0	9	8
99	R:R:F290	R:R:V363	6.55	Yes	No	0	9	9
100	R:R:I292	R:R:M291	4.37	No	No	0	5	7
101	R:R:F362	R:R:L293	9.74	No	Yes	0	7	6
102	R:R:M298	R:R:Y294	10.78	No	Yes	0	7	9
103	R:R:L342	R:R:Y294	5.86	No	Yes	0	7	9
104	R:R:F362	R:R:Y294	5.16	No	Yes	0	7	9
105	R:R:F295	R:R:F296	12.86	Yes	No	0	8	8
106	R:R:F295	R:R:W336	4.01	Yes	Yes	0	8	9
107	R:R:F295	R:R:P339	4.33	Yes	Yes	0	8	9
108	R:R:M298	R:R:P339	3.35	No	Yes	0	7	9
109	R:R:A299	R:R:W336	3.89	No	Yes	0	9	9
110	R:R:A299	R:R:P339	3.74	No	Yes	0	9	9
111	R:R:S301	R:R:Y382	8.9	No	No	0	6	5
112	R:R:V302	R:R:Y382	5.05	No	No	0	5	5
113	R:R:I306	R:R:W303	7.05	No	Yes	0	7	9
114	R:R:H332	R:R:W303	7.41	No	Yes	5	9	9
115	R:R:A335	R:R:W303	9.08	No	Yes	0	9	9
116	R:R:W303	R:R:W336	18.74	Yes	Yes	5	9	9
117	R:R:V305	R:R:W304	3.68	No	Yes	0	8	9
118	R:R:T308	R:R:W304	7.28	No	Yes	2	7	9
119	R:R:G386	R:R:W304	4.22	No	Yes	2	9	9
120	R:R:F424	R:R:W304	6.01	Yes	Yes	0	9	9
121	R:R:W304	R:R:Y428	43.41	Yes	Yes	2	9	8
122	R:R:L429	R:R:W304	7.97	Yes	Yes	2	7	9
123	R:R:L307	R:R:W311	13.67	No	No	0	9	9
124	R:R:G386	R:R:T308	5.46	No	No	2	9	7
125	R:R:L390	R:R:T308	4.42	No	No	0	8	7
126	R:R:I421	R:R:W311	17.62	No	No	0	8	9
127	R:R:W311	R:R:W497	5.62	No	Yes	0	9	9
128	R:R:F312	R:R:V316	3.93	No	No	3	7	7
129	R:R:F312	R:R:P317	7.22	No	Yes	3	7	7
130	R:R:L313	R:R:P317	6.57	No	Yes	3	8	7
131	R:R:L313	R:R:W319	11.39	No	Yes	3	8	8
132	R:R:I324	R:R:L313	5.71	Yes	No	3	9	8
133	R:R:A315	R:R:L397	3.15	No	No	0	8	8
134	R:R:P317	R:R:V316	7.07	Yes	No	3	7	7
135	R:R:S396	R:R:V316	9.7	No	No	0	8	7
136	R:R:P317	R:R:W319	6.76	Yes	Yes	3	7	8
137	R:R:I324	R:R:W319	4.7	Yes	Yes	3	9	8
138	R:R:A328	R:R:E325	4.53	No	No	0	8	7
139	R:R:F331	R:R:K327	3.72	No	No	0	8	6
140	R:R:H332	R:R:W336	8.46	No	Yes	5	9	9
141	R:R:I338	R:R:P339	3.39	No	Yes	0	4	9
142	R:R:D367	R:R:K351	13.83	No	No	6	6	6
143	R:R:D369	R:R:K351	4.15	No	No	6	2	6
144	R:R:A370	R:R:K351	3.21	No	No	6	6	6
145	R:R:C361	R:R:I352	3.27	No	Yes	0	9	8
146	R:R:E353	R:R:G354	4.91	Yes	No	1	7	8
147	R:R:E353	R:R:Y366	5.61	Yes	Yes	1	7	5
148	R:R:D355	R:R:G354	3.35	No	No	0	9	8
149	R:R:D355	R:R:G359	5.03	No	No	0	9	9
150	R:R:N356	R:R:S358	8.94	No	No	0	6	8
151	R:R:G359	R:R:N356	3.39	No	No	0	9	6
152	R:R:F362	R:R:V363	3.93	No	No	0	7	9
153	R:R:G364	R:R:V363	3.68	No	No	0	8	9
154	R:R:G364	R:R:L371	3.42	No	No	0	8	8
155	R:R:D367	R:R:D369	3.99	No	No	6	6	2
156	R:R:A370	R:R:D367	4.63	No	No	6	6	6
157	R:R:Q443	R:R:V368	4.3	No	No	0	5	3
158	R:R:R446	R:R:V368	3.92	No	No	0	6	3
159	R:R:Q443	R:R:R372	24.53	No	No	0	5	6
160	R:R:F374	R:R:Y373	3.09	No	No	0	8	2
161	R:R:C380	R:R:L376	3.17	No	No	7	3	6
162	R:R:I436	R:R:L376	4.28	No	No	7	6	6
163	R:R:F440	R:R:L376	10.96	No	No	0	4	6
164	R:R:P378	R:R:Y382	4.17	No	No	0	9	5
165	R:R:C380	R:R:I436	8.18	No	No	7	3	6
166	R:R:L429	R:R:V383	4.47	Yes	No	0	7	8
167	R:R:L432	R:R:V383	4.47	No	No	0	7	8
168	R:R:L389	R:R:S388	4.5	No	No	0	8	3
169	R:R:I394	R:R:L390	5.71	No	No	0	7	8
170	R:R:L390	R:R:S425	6.01	No	No	0	8	8
171	R:R:G393	R:R:S396	3.71	No	No	0	9	8
172	R:R:I395	R:R:N398	5.66	No	No	0	5	6
173	R:R:L397	R:R:M418	4.24	No	No	0	8	8
174	R:R:Q411	R:R:R401	5.84	No	No	0	7	9
175	R:R:E407	R:R:L406	5.3	No	No	0	6	4
176	R:R:D412	R:R:V415	11.69	No	No	0	4	8
177	R:R:L414	R:R:M418	4.24	No	No	0	9	8
178	R:R:I419	R:R:V415	3.07	No	No	0	5	8
179	R:R:F417	R:R:I421	7.54	No	No	0	8	8
180	R:R:R420	R:R:W497	22.99	No	Yes	0	9	9
181	R:R:R420	R:R:S500	13.18	No	No	0	9	9
182	R:R:K501	R:R:R420	4.95	No	No	0	5	9
183	R:R:G422	R:R:I421	3.53	No	No	0	7	8
184	R:R:F424	R:R:P493	5.78	Yes	No	0	9	8
185	R:R:F424	R:R:W497	4.01	Yes	Yes	0	9	9
186	R:R:L427	R:R:P493	4.93	No	No	0	7	8
187	R:R:F496	R:R:L427	3.65	No	No	0	6	7
188	R:R:L429	R:R:Y428	3.52	Yes	Yes	2	7	8
189	R:R:L432	R:R:Y428	15.24	No	Yes	2	7	8
190	R:R:V490	R:R:Y428	3.79	Yes	Yes	2	8	8
191	R:R:P431	R:R:V430	5.3	Yes	No	0	9	5
192	R:R:M486	R:R:P431	5.03	No	Yes	0	7	9
193	R:R:I489	R:R:P431	5.08	No	Yes	0	5	9
194	R:R:P431	R:R:V490	3.53	Yes	Yes	0	9	8
195	R:R:L432	R:R:V490	4.47	No	Yes	2	7	8
196	R:R:M486	R:R:V434	13.69	No	No	0	7	5
197	R:R:C438	R:R:K483	9.7	No	Yes	0	7	8
198	R:R:K483	R:R:Y439	8.36	Yes	No	0	8	5
199	R:R:M472	R:R:Y441	4.79	Yes	No	4	1	9
200	R:R:P475	R:R:Y441	6.95	Yes	No	4	8	9
201	R:R:L479	R:R:Y441	5.86	Yes	No	4	6	9
202	R:R:E442	R:R:R446	17.45	No	No	0	9	6
203	R:R:E442	R:R:F480	11.66	No	No	0	9	6
204	R:R:E442	R:R:K483	9.45	No	Yes	0	9	8
205	R:R:W449	R:R:Y445	3.86	Yes	No	0	9	4
206	R:R:Q471	R:R:Y445	4.51	No	No	0	2	4
207	R:R:M472	R:R:Y445	15.57	Yes	No	0	1	4
208	R:R:I448	R:R:Q468	5.49	No	No	0	3	2
209	R:R:W449	R:R:W453	13.12	Yes	No	0	9	5
210	R:R:R457	R:R:W453	14.99	No	No	0	4	5
211	R:R:E456	R:R:Y461	3.37	No	No	0	4	4
212	R:R:E460	R:R:Y461	4.49	No	No	0	3	4
213	R:R:M472	R:R:P475	3.35	Yes	Yes	4	1	8
214	R:R:P475	R:R:S473	3.56	Yes	No	0	8	3
215	R:R:D476	R:R:R474	7.15	No	No	0	5	4
216	R:R:I478	R:R:R474	6.26	Yes	No	0	5	4
217	R:R:I478	R:R:P475	5.08	Yes	Yes	4	5	8
218	R:R:L479	R:R:P475	9.85	Yes	Yes	4	6	8
219	R:R:I478	R:R:L477	4.28	Yes	No	0	5	5
220	R:R:I478	R:R:L479	4.28	Yes	Yes	4	5	6
221	R:R:L479	R:R:M482	4.24	Yes	No	0	6	6
222	R:R:I492	R:R:P493	5.08	No	No	0	8	8
223	R:R:I492	R:R:V495	3.07	No	No	0	8	8
224	R:R:I352	R:R:T287	3.04	Yes	No	0	8	7
225	R:R:I448	R:R:T451	3.04	No	No	0	3	3
226	R:R:I448	R:R:T452	3.04	No	No	0	3	5
227	R:R:F295	R:R:G340	3.01	Yes	No	0	8	7
228	R:R:L175	R:R:S281	3	No	No	0	3	6
229	R:R:L488	R:R:S249	3	Yes	No	0	8	8
230	R:R:L379	R:R:S301	3	No	No	0	7	6
231	R:R:L371	R:R:V375	2.98	No	No	0	8	7
232	R:R:L381	R:R:V385	2.98	No	No	0	4	4
233	R:R:L391	R:R:V387	2.98	No	No	0	4	6
234	R:R:L429	R:R:V387	2.98	Yes	No	0	7	6
235	R:R:L427	R:R:V423	2.98	No	No	0	7	6
236	R:R:I238	R:R:I239	2.94	No	No	0	9	8
237	R:R:I306	R:R:I309	2.94	No	No	0	7	6
238	R:R:D260	R:R:V262	2.92	No	No	0	6	6
239	R:R:D369	R:R:V368	2.92	No	No	0	2	3
240	R:R:M246	R:R:M247	2.89	No	No	0	5	5
241	R:R:K284	R:R:M288	2.88	No	No	0	6	5
242	R:R:I209	R:R:L488	2.85	No	Yes	0	5	8
243	R:R:I309	R:R:L389	2.85	No	No	0	6	8
244	R:R:I436	R:R:L379	2.85	No	No	0	6	7
245	R:R:L250	R:R:M247	2.83	No	No	0	4	5
246	R:R:L289	R:R:M288	2.83	No	No	0	7	5
247	R:R:L379	R:R:M298	2.83	No	No	0	7	7
248	R:R:I345	R:R:N350	2.83	No	No	0	4	6
249	R:R:Q471	R:R:T452	2.83	No	No	0	2	5
250	R:R:Q471	R:R:T470	2.83	No	No	0	2	1
251	R:R:L218	R:R:L222	2.77	No	No	0	4	6
252	R:R:L346	R:R:N350	2.75	No	No	0	7	6
253	R:R:I454	R:R:Q455	2.74	No	No	0	3	3
254	R:R:E403	R:R:I402	2.73	No	No	0	5	5
255	R:R:E322	R:R:K326	2.7	No	No	0	9	5
256	R:R:E407	R:R:N410	2.63	No	No	0	6	7
257	R:R:R401	R:R:V415	2.62	No	No	0	9	8
258	R:R:F331	R:R:T310	2.59	No	No	0	8	8
259	R:R:F221	R:R:I239	2.51	No	No	0	7	8
260	R:R:I254	R:R:R261	2.51	No	No	0	4	3
261	R:R:L199	R:R:R196	2.43	No	No	0	6	4
262	R:R:I206	R:R:Y484	2.42	No	No	0	7	8
263	R:R:E403	R:R:R399	2.33	No	No	0	5	6
264	R:R:E450	R:R:W449	2.18	No	Yes	0	6	9
265	R:R:E456	R:R:W453	2.18	No	No	0	4	5
266	R:R:F201	R:R:Y204	2.06	No	No	0	6	4
267	R:R:R372	R:R:Y373	2.06	No	No	0	6	2
268	R:R:P187	R:R:P188	1.95	Yes	No	0	5	5
269	R:R:P188	R:R:P190	1.95	No	No	0	5	3
270	R:R:A323	R:R:G320	1.95	No	No	0	8	7
271	R:R:C165	R:R:P166	1.88	No	No	0	9	6
272	R:R:C189	R:R:P190	1.88	No	No	0	9	3
273	R:R:A377	R:R:P378	1.87	No	No	0	4	9
274	R:R:G499	R:R:V498	1.84	No	No	0	7	7
275	R:R:G176	R:R:K170	1.74	No	No	0	2	5
276	R:R:C213	R:R:S249	1.72	No	No	0	8	8
277	R:R:C185	R:R:V182	1.71	No	No	0	9	5
278	R:R:A202	R:R:S358	1.71	No	No	0	7	8
279	R:R:A242	R:R:S494	1.71	No	No	0	8	8
280	R:R:A216	R:R:V495	1.7	No	No	0	8	8
281	R:R:C213	R:R:T217	1.69	No	No	0	8	8
282	R:R:I404	R:R:P405	1.69	No	No	0	7	7
283	R:R:D184	R:R:G176	1.68	No	No	0	6	2
284	R:R:S275	R:R:V277	1.62	No	No	0	3	6
285	R:R:S334	R:R:V302	1.62	No	No	0	5	5
286	R:R:A314	R:R:I324	1.62	No	Yes	0	8	9
287	R:R:V305	R:R:V385	1.6	No	No	0	8	4
288	R:R:C361	R:R:L289	1.59	No	No	0	9	7
289	R:R:A348	R:R:L347	1.58	No	No	0	7	8
290	R:R:I212	R:R:S215	1.55	No	No	0	5	3
291	R:R:I404	R:R:V400	1.54	No	No	0	7	8
292	R:R:I419	R:R:V423	1.54	No	No	0	5	6
293	R:R:I426	R:R:V430	1.54	No	No	0	5	5
294	R:R:I324	R:R:T310	1.52	Yes	No	0	9	8
295	R:R:M486	R:R:V435	1.52	No	No	0	7	7
296	R:R:M291	R:R:T343	1.51	No	No	0	7	9
297	R:R:F440	R:R:G437	1.51	No	No	0	4	5
298	R:R:L175	R:R:S178	1.5	No	No	0	3	3
299	R:R:I211	R:R:I212	1.47	No	No	0	3	5
300	R:R:L342	R:R:T341	1.47	No	No	0	7	4
301	R:R:K326	R:R:K327	1.44	No	No	0	5	6
302	R:R:I171	R:R:L169	1.43	No	No	0	4	6
303	R:R:K483	R:R:L365	1.41	Yes	No	0	8	6
304	R:R:K413	R:R:N410	1.4	No	No	0	9	7
305	R:R:C458	R:R:R459	1.39	No	No	0	9	4
306	R:R:L214	R:R:L218	1.38	No	No	0	4	4
307	R:R:A323	R:R:W319	1.3	No	Yes	0	8	8
308	R:R:M418	R:R:R401	1.24	No	No	0	8	9
309	R:R:D184	R:R:R183	1.19	No	No	0	6	3
310	R:R:D260	R:R:R261	1.19	No	No	0	6	3
311	R:R:L208	R:R:Y204	1.17	No	No	0	3	4
312	R:R:E259	R:R:F256	1.17	No	No	0	6	6
313	R:R:Q455	R:R:R459	1.17	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P187	4.5025	4	1	5
2	R:R:Y193	12.302	5	0	5
3	R:R:F194	7.37	4	0	6
4	R:R:Q279	9.04	4	1	7
5	R:R:F290	8.41	4	0	9
6	R:R:L293	7.165	4	0	6
7	R:R:Y294	7.255	4	0	9
8	R:R:F295	6.0525	4	0	8
9	R:R:W303	11.6217	6	5	9
10	R:R:W304	12.095	6	2	9
11	R:R:P317	6.905	4	3	7
12	R:R:W319	6.0375	4	3	8
13	R:R:I324	3.3875	4	3	9
14	R:R:W336	8.775	4	5	9
15	R:R:P339	3.7025	4	0	9
16	R:R:I352	5.4925	4	0	8
17	R:R:E353	6.34	4	1	7
18	R:R:Y366	5.83	4	1	5
19	R:R:F424	4.8925	4	0	9
20	R:R:Y428	14.98	5	2	8
21	R:R:L429	4.735	4	2	7
22	R:R:P431	4.735	4	0	9
23	R:R:W449	14.435	4	0	9
24	R:R:M472	8.415	4	4	1
25	R:R:P475	5.758	5	4	8
26	R:R:I478	4.975	4	4	5
27	R:R:L479	6.0575	4	4	6
28	R:R:K483	7.23	4	0	8
29	R:R:L488	3.5	4	0	8
30	R:R:V490	5.7875	4	2	8
31	R:R:W497	10.6075	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R167	R:R:Y177	11.4179	21.61	No	No	0	3	6
2	R:R:Q279	R:R:Y177	10.4854	13.53	Yes	No	1	7	6
3	R:R:C286	R:R:Q279	74.2672	4.58	No	Yes	0	9	7
4	R:R:C286	R:R:C361	74.9876	7.28	No	No	0	9	9
5	R:R:C361	R:R:I352	78.5106	3.27	No	Yes	0	9	8
6	R:R:E353	R:R:Y366	58.1266	5.61	Yes	Yes	1	7	5
7	R:R:Y193	R:R:Y366	50.6614	5.96	Yes	Yes	0	5	5
8	R:R:W449	R:R:Y193	15.876	38.58	Yes	Yes	0	9	5
9	R:R:F194	R:R:Y193	18.87	3.09	Yes	Yes	0	6	5
10	R:R:R446	R:R:Y193	17.2958	10.29	No	Yes	0	6	5
11	R:R:F290	R:R:I352	85.1638	12.56	Yes	Yes	0	9	8
12	R:R:F290	R:R:Y294	77.6619	7.22	Yes	Yes	0	9	9
13	R:R:F362	R:R:Y294	42.2008	5.16	No	Yes	0	7	9
14	R:R:F362	R:R:L293	50.5697	9.74	No	Yes	0	7	6
15	R:R:F252	R:R:L293	42.9971	7.31	No	Yes	0	8	6
16	R:R:F252	R:R:L488	39.6731	3.65	No	Yes	0	8	8
17	R:R:L488	R:R:S249	23.5377	3	Yes	No	0	8	8
18	R:R:L214	R:R:S249	19.9466	9.01	No	No	0	4	8
19	R:R:I211	R:R:L214	16.3082	4.28	No	No	0	3	4
20	R:R:F253	R:R:I211	12.6228	11.3	No	No	0	5	3
21	R:R:F253	R:R:L257	11.3838	8.53	No	No	0	5	4
22	R:R:I254	R:R:L257	10.1396	4.28	No	No	0	4	4
23	R:R:F290	R:R:V363	15.1269	6.55	Yes	No	0	9	9
24	R:R:F362	R:R:V363	14.5402	3.93	No	No	0	7	9
25	R:R:L488	R:R:S210	11.3838	4.5	Yes	No	0	8	8
26	R:R:G207	R:R:S210	10.1396	3.71	No	No	0	6	8
27	R:R:M298	R:R:Y294	97.5142	10.78	No	Yes	0	7	9
28	R:R:M298	R:R:P339	100	3.35	No	Yes	0	7	9
29	R:R:F295	R:R:P339	60.4683	4.33	Yes	Yes	0	8	9
30	R:R:F295	R:R:W336	41.7974	4.01	Yes	Yes	0	8	9
31	R:R:W303	R:R:W336	71.2549	18.74	Yes	Yes	5	9	9
32	R:R:P237	R:R:W303	60.3295	5.4	No	Yes	0	8	9
33	R:R:L307	R:R:P237	43.0338	11.49	No	No	0	9	8
34	R:R:L307	R:R:W311	42.1929	13.67	No	No	0	9	9
35	R:R:W311	R:R:W497	38.8847	5.62	No	Yes	0	9	9
36	R:R:F424	R:R:W497	33.8109	4.01	Yes	Yes	0	9	9
37	R:R:F424	R:R:I238	15.2867	3.77	Yes	No	0	9	9
38	R:R:I238	R:R:I239	14.142	2.94	No	No	0	9	8
39	R:R:A299	R:R:P339	39.9848	3.74	No	Yes	0	9	9
40	R:R:A299	R:R:W336	39.8041	3.89	No	Yes	0	9	9
41	R:R:F240	R:R:W303	10.4487	22.05	No	Yes	5	8	9
42	R:R:F240	R:R:R236	16.9055	3.21	No	No	0	8	9
43	R:R:A328	R:R:R236	14.8021	4.15	No	No	0	8	9
44	R:R:A328	R:R:E325	12.759	4.53	No	No	0	8	7
45	R:R:E325	R:R:Y233	10.6452	10.1	No	No	0	7	9
46	R:R:P237	R:R:T310	23.818	3.5	No	No	0	8	8
47	R:R:F295	R:R:F296	22.2045	12.86	Yes	No	0	8	8
48	R:R:C244	R:R:F296	20.8214	4.19	No	No	0	9	8
49	R:R:C244	R:R:G300	20.5097	3.92	No	No	0	9	8
50	R:R:G300	R:R:Y245	20.2242	5.79	No	No	0	8	8
51	R:R:V490	R:R:Y245	12.1487	11.36	Yes	No	0	8	8
52	R:R:L379	R:R:M298	12.0675	2.83	No	No	0	7	7
53	R:R:W304	R:R:Y428	12.0229	43.41	Yes	Yes	2	9	8
54	R:R:I324	R:R:T310	18.3959	1.52	Yes	No	0	9	8
55	R:R:I419	R:R:V423	10.6163	1.54	No	No	0	5	6
56	R:R:L427	R:R:V423	11.7767	2.98	No	No	0	7	6
57	R:R:L427	R:R:P493	14.0818	4.93	No	No	0	7	8
58	R:R:F424	R:R:P493	18.629	5.78	Yes	No	0	9	8
59	R:R:R446	R:R:V368	11.1926	3.92	No	No	0	6	3
60	R:R:E353	R:R:Q279	56.6807	11.47	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8QW4

PDB Summary
PDB	8QW4
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD3
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.9
Date	2024-09-04
D.O.I.	doi.org/10.1038/s41467-024-51451-1

Net Summary
I_min	3.07
Number of Linked Nodes	294
Number of Links	313
Number of Hubs	31
Number of Links mediated by Hubs	106
Number of Communities	7
Number of Nodes involved in Communities	37
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	63379
Length Of Smallest Path	3
Average Path Length	16.7118
Length of Longest Path	34
Minimum Path Strength	1.28
Average Path Strength	7.06631
Maximum Path Strength	29.325
Minimum Path Correlation	0.7
Average Path Correlation	0.937768
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	49.3909
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7265
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NPG1
Sequence	>8QW4_Chain_R C P R E L K I L G Y S F L H V R D C S P P C P N M Y F R R E E L S F A R Y F I G L I S I I C L S A T L F T F L T F L I T R F R Y P E R P I I F Y A V C Y M M V S L I F F I G F L L E D R V A C N A S S T V T Q G S H N K A C T M L F M I L Y F F T M A G S V W W V I L T I T W F L A A V P K W G S E A I E K K A L L F H A S A W G I P G T L T I I L L A M N K I E G D N I S G V C F V G L Y D V D A L R Y F V L A P L C L Y V V V G V S L L L A G I I S L N R V R I E I P L E K E N Q D K L V K F M I R I G V F S I L Y L V P L L V V I G C Y F Y E Q A Y R G I W E T T W I Q E R C R E Y Q V T Q M S R P D L I L F L M K Y L M A L I V G I P S V F W V G S K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHC	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	-	3.3	2024-01-17	doi.org/10.1038/s41421-023-00627-y
	8JHI	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	chim(NtGsXLas-Gs)/β1/γ2	3.2	2024-01-17	doi.org/10.1038/s41421-023-00627-y
	8JHI (No Gprot)	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-		3.2	2024-01-17	doi.org/10.1038/s41421-023-00627-y

there is no ligand in network 8QW4

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.