psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C165	R:R:P166	3.77	No	No	0	9	6
2	R:R:C165	R:R:C185	7.28	No	No	0	9	9
3	R:R:E168	R:R:P166	6.29	No	No	5	5	6
4	R:R:L169	R:R:P166	6.57	No	No	5	6	6
5	R:R:H462	R:R:R167	11.28	No	No	0	6	3
6	R:R:E168	R:R:L169	10.6	No	No	5	5	6
7	R:R:E168	R:R:Y461	10.1	No	No	0	5	4
8	R:R:L169	R:R:P188	6.57	No	No	0	6	5
9	R:R:D184	R:R:K170	11.06	No	No	0	6	5
10	R:R:I171	R:R:Y177	12.09	No	Yes	0	4	6
11	R:R:D184	R:R:I171	5.6	No	No	0	6	4
12	R:R:G176	R:R:R183	9.01	No	No	0	2	3
13	R:R:S186	R:R:Y177	6.36	No	Yes	0	6	6
14	R:R:Q279	R:R:Y177	24.8	No	Yes	0	7	6
15	R:R:H282	R:R:Y177	7.62	No	Yes	0	6	6
16	R:R:Q279	R:R:S178	5.78	No	No	0	7	3
17	R:R:D367	R:R:S178	4.42	Yes	No	0	6	3
18	R:R:F179	R:R:L180	7.31	No	No	0	5	4
19	R:R:F179	R:R:P187	13	No	Yes	0	5	5
20	R:R:F179	R:R:P188	4.33	No	No	0	5	5
21	R:R:C185	R:R:V182	3.42	No	No	0	9	5
22	R:R:P187	R:R:S186	3.56	Yes	No	0	5	6
23	R:R:S186	R:R:T276	9.59	No	No	0	6	5
24	R:R:P187	R:R:V277	7.07	Yes	No	0	5	6
25	R:R:P187	R:R:Y366	9.74	Yes	No	0	5	5
26	R:R:M192	R:R:P188	5.03	No	No	0	7	5
27	R:R:C189	R:R:P190	7.53	No	No	0	9	3
28	R:R:C189	R:R:C264	7.28	No	No	0	9	9
29	R:R:N191	R:R:P190	8.15	No	No	0	4	3
30	R:R:M192	R:R:Y193	4.79	No	No	0	7	5
31	R:R:M192	R:R:N356	7.01	No	Yes	0	7	6
32	R:R:W453	R:R:Y193	6.75	No	No	0	5	5
33	R:R:P475	R:R:Y193	4.17	Yes	No	0	8	5
34	R:R:F194	R:R:P475	5.78	No	Yes	0	6	8
35	R:R:F194	R:R:L477	7.31	No	No	0	6	5
36	R:R:F194	R:R:F480	4.29	No	No	0	6	6
37	R:R:R195	R:R:R196	6.4	No	No	6	4	4
38	R:R:E198	R:R:R195	8.14	No	No	6	7	4
39	R:R:E197	R:R:R196	6.98	No	No	0	4	4
40	R:R:E198	R:R:R196	5.82	No	No	6	7	4
41	R:R:E197	R:R:S200	7.19	No	No	0	4	3
42	R:R:E198	R:R:L477	9.28	No	No	0	7	5
43	R:R:F256	R:R:R203	19.24	No	No	0	6	7
44	R:R:F205	R:R:I209	5.02	No	Yes	0	7	5
45	R:R:F205	R:R:L481	17.05	No	No	0	7	8
46	R:R:I206	R:R:S358	4.64	No	No	0	7	8
47	R:R:G207	R:R:S210	3.71	No	No	0	6	8
48	R:R:I209	R:R:L485	8.56	Yes	No	0	5	7
49	R:R:C213	R:R:L214	4.76	No	No	7	8	4
50	R:R:C213	R:R:S249	3.44	No	No	7	8	8
51	R:R:C213	R:R:L488	4.76	No	No	0	8	8
52	R:R:L214	R:R:S249	6.01	No	No	7	4	8
53	R:R:F253	R:R:L214	4.87	No	No	0	5	4
54	R:R:T217	R:R:T220	7.85	Yes	No	0	8	8
55	R:R:A242	R:R:T217	5.03	No	Yes	1	8	8
56	R:R:M246	R:R:T217	4.52	No	Yes	0	5	8
57	R:R:S494	R:R:T217	7.99	No	Yes	1	8	8
58	R:R:A242	R:R:F221	4.16	No	Yes	0	8	7
59	R:R:F221	R:R:V243	6.55	Yes	No	0	7	5
60	R:R:F221	R:R:M246	4.98	Yes	No	0	7	5
61	R:R:F224	R:R:V228	6.55	No	No	0	9	6
62	R:R:F224	R:R:I239	8.79	No	No	0	9	8
63	R:R:D227	R:R:I226	5.6	No	No	0	8	7
64	R:R:I226	R:R:K502	7.27	No	No	0	7	9
65	R:R:D227	R:R:R230	5.96	No	No	0	8	9
66	R:R:F231	R:R:R230	9.62	No	No	0	9	9
67	R:R:R232	R:R:S321	6.59	No	No	0	6	6
68	R:R:R236	R:R:Y233	10.29	No	Yes	0	9	9
69	R:R:T310	R:R:Y233	4.99	No	Yes	0	8	9
70	R:R:I324	R:R:Y233	7.25	No	Yes	0	9	9
71	R:R:E325	R:R:Y233	5.61	No	Yes	0	7	9
72	R:R:A328	R:R:Y233	6.67	No	Yes	0	8	9
73	R:R:F331	R:R:Y233	7.22	No	Yes	0	8	9
74	R:R:A314	R:R:P234	3.74	No	No	0	8	9
75	R:R:P234	R:R:S321	7.13	No	No	0	9	6
76	R:R:I324	R:R:P234	3.39	No	No	0	9	9
77	R:R:E235	R:R:W497	11.99	No	Yes	0	9	9
78	R:R:F240	R:R:R236	6.41	Yes	No	0	8	9
79	R:R:P237	R:R:W303	5.4	No	Yes	2	8	9
80	R:R:I306	R:R:P237	3.39	No	No	2	7	8
81	R:R:I238	R:R:W497	3.52	No	Yes	0	9	9
82	R:R:F240	R:R:I239	7.54	Yes	No	0	8	8
83	R:R:F240	R:R:W303	22.05	Yes	Yes	2	8	9
84	R:R:F240	R:R:H332	3.39	Yes	No	2	8	9
85	R:R:Y241	R:R:Y245	5.96	Yes	No	0	8	8
86	R:R:Y241	R:R:Y428	9.93	Yes	Yes	1	8	8
87	R:R:P493	R:R:Y241	8.34	Yes	Yes	1	8	8
88	R:R:S494	R:R:Y241	5.09	No	Yes	1	8	8
89	R:R:A242	R:R:S494	3.42	No	No	1	8	8
90	R:R:C244	R:R:F296	4.19	No	No	0	9	8
91	R:R:A299	R:R:C244	3.61	No	No	0	9	9
92	R:R:C244	R:R:G300	3.92	No	No	0	9	8
93	R:R:G300	R:R:Y245	4.35	No	No	0	8	8
94	R:R:V490	R:R:Y245	5.05	No	No	0	8	8
95	R:R:M246	R:R:S249	9.2	No	No	0	5	8
96	R:R:F296	R:R:M247	9.95	No	No	0	8	5
97	R:R:L293	R:R:V248	4.47	No	No	0	6	7
98	R:R:T297	R:R:V248	6.35	No	No	0	6	7
99	R:R:I251	R:R:L289	5.71	No	No	0	6	7
100	R:R:I251	R:R:I292	5.89	No	No	0	6	5
101	R:R:I251	R:R:L293	11.42	No	No	0	6	6
102	R:R:F252	R:R:S358	5.28	No	No	0	8	8
103	R:R:F252	R:R:L488	3.65	No	No	0	8	8
104	R:R:F253	R:R:L257	8.53	No	No	0	5	4
105	R:R:L258	R:R:V262	8.94	No	No	0	4	6
106	R:R:D260	R:R:E259	5.2	No	No	0	6	6
107	R:R:E259	R:R:R261	3.49	No	No	0	6	3
108	R:R:N265	R:R:S275	4.47	No	No	0	4	3
109	R:R:N283	R:R:T278	4.39	No	Yes	0	7	6
110	R:R:E353	R:R:Q279	5.1	No	No	0	7	7
111	R:R:G280	R:R:H282	4.77	No	No	0	6	6
112	R:R:N350	R:R:S281	4.47	No	No	0	6	6
113	R:R:I352	R:R:S281	4.64	Yes	No	0	8	6
114	R:R:C286	R:R:I352	4.91	No	Yes	0	9	8
115	R:R:C286	R:R:C361	7.28	No	No	8	9	9
116	R:R:F290	R:R:M291	3.73	Yes	No	0	9	7
117	R:R:F290	R:R:Y294	8.25	Yes	Yes	4	9	9
118	R:R:F290	R:R:L346	6.09	Yes	Yes	4	9	7
119	R:R:F290	R:R:I352	10.05	Yes	Yes	0	9	8
120	R:R:F290	R:R:V363	5.24	Yes	Yes	4	9	9
121	R:R:L347	R:R:M291	7.07	No	No	0	8	7
122	R:R:M298	R:R:Y294	10.78	No	Yes	0	7	9
123	R:R:L346	R:R:Y294	5.86	Yes	Yes	4	7	9
124	R:R:F362	R:R:Y294	7.22	No	Yes	0	7	9
125	R:R:F295	R:R:F296	8.57	Yes	No	0	8	8
126	R:R:F295	R:R:W336	5.01	Yes	No	0	8	9
127	R:R:F295	R:R:P339	7.22	Yes	Yes	0	8	9
128	R:R:F295	R:R:T343	10.38	Yes	No	0	8	9
129	R:R:M298	R:R:P339	3.35	No	Yes	0	7	9
130	R:R:S301	R:R:Y382	6.36	No	Yes	0	6	5
131	R:R:P339	R:R:V302	3.53	Yes	No	0	9	5
132	R:R:V302	R:R:Y382	6.31	No	Yes	0	5	5
133	R:R:I306	R:R:W303	7.05	No	Yes	2	7	9
134	R:R:H332	R:R:W303	8.46	No	Yes	2	9	9
135	R:R:A335	R:R:W303	9.08	No	Yes	0	9	9
136	R:R:W303	R:R:W336	14.06	Yes	No	2	9	9
137	R:R:T308	R:R:W304	7.28	No	No	0	7	9
138	R:R:W304	R:R:Y428	24.12	No	Yes	0	9	8
139	R:R:V305	R:R:Y382	3.79	No	Yes	0	8	5
140	R:R:F331	R:R:I306	3.77	No	No	0	8	7
141	R:R:G386	R:R:T308	5.46	No	No	0	9	7
142	R:R:F331	R:R:I309	3.77	No	No	0	8	6
143	R:R:L390	R:R:W311	4.56	No	Yes	0	8	9
144	R:R:G393	R:R:W311	4.22	No	Yes	0	9	9
145	R:R:F417	R:R:W311	5.01	No	Yes	0	8	9
146	R:R:F312	R:R:L313	3.65	No	No	0	7	8
147	R:R:F312	R:R:V316	6.55	No	No	0	7	7
148	R:R:F312	R:R:L389	10.96	No	No	0	7	8
149	R:R:I324	R:R:L313	4.28	No	No	0	9	8
150	R:R:P317	R:R:V316	5.3	No	No	0	7	7
151	R:R:S396	R:R:V316	9.7	No	No	0	8	7
152	R:R:P317	R:R:W319	8.11	No	No	0	7	8
153	R:R:K326	R:R:K327	4.31	No	No	0	5	6
154	R:R:H332	R:R:W336	7.41	No	No	2	9	9
155	R:R:I338	R:R:P339	3.39	No	Yes	0	4	9
156	R:R:L346	R:R:V363	7.45	Yes	Yes	4	7	9
157	R:R:F374	R:R:L346	17.05	No	Yes	0	8	7
158	R:R:I352	R:R:L347	4.28	Yes	No	0	8	8
159	R:R:K351	R:R:M349	8.64	No	No	0	6	4
160	R:R:A370	R:R:K351	4.82	No	No	0	6	6
161	R:R:D367	R:R:E353	9.09	Yes	No	0	6	7
162	R:R:D355	R:R:N356	4.04	Yes	Yes	3	9	6
163	R:R:D355	R:R:I357	5.6	Yes	Yes	3	9	8
164	R:R:D355	R:R:V360	4.38	Yes	No	0	9	7
165	R:R:D355	R:R:L365	4.07	Yes	No	0	9	6
166	R:R:D355	R:R:Y484	11.49	Yes	No	3	9	8
167	R:R:I357	R:R:N356	8.5	Yes	Yes	3	8	6
168	R:R:N356	R:R:Y366	3.49	Yes	No	0	6	5
169	R:R:I357	R:R:Y484	6.04	Yes	No	3	8	8
170	R:R:F362	R:R:V363	5.24	No	Yes	0	7	9
171	R:R:F362	R:R:L365	3.65	No	No	0	7	6
172	R:R:G364	R:R:V363	3.68	No	Yes	0	8	9
173	R:R:D367	R:R:G364	5.03	Yes	No	0	6	8
174	R:R:G364	R:R:L371	5.13	No	Yes	0	8	8
175	R:R:A370	R:R:D367	4.63	No	Yes	0	6	6
176	R:R:D369	R:R:V368	4.38	No	No	0	2	3
177	R:R:R372	R:R:V368	5.23	No	No	0	6	3
178	R:R:D369	R:R:Y373	3.45	No	No	0	2	2
179	R:R:L371	R:R:V375	5.96	Yes	No	9	8	7
180	R:R:L371	R:R:Y439	3.52	Yes	Yes	9	8	5
181	R:R:L371	R:R:Q443	5.32	Yes	No	0	8	5
182	R:R:Q443	R:R:R372	12.85	No	No	0	5	6
183	R:R:V375	R:R:Y439	3.79	No	Yes	9	7	5
184	R:R:L376	R:R:Y439	7.03	No	Yes	0	6	5
185	R:R:F440	R:R:L376	4.87	No	No	0	4	6
186	R:R:L429	R:R:V387	4.47	No	No	0	7	6
187	R:R:L389	R:R:S388	6.01	No	No	0	8	3
188	R:R:I394	R:R:M418	4.37	No	No	0	7	8
189	R:R:L397	R:R:M418	7.07	No	No	0	8	8
190	R:R:N398	R:R:R401	4.82	No	No	0	6	9
191	R:R:Q411	R:R:R401	9.35	Yes	No	0	7	9
192	R:R:M418	R:R:R401	4.96	No	No	0	8	9
193	R:R:I404	R:R:P405	3.39	Yes	No	10	7	7
194	R:R:E409	R:R:I404	5.47	No	Yes	0	6	7
195	R:R:I404	R:R:Q411	8.23	Yes	Yes	10	7	7
196	R:R:P405	R:R:Q411	20.53	No	Yes	10	7	7
197	R:R:E409	R:R:K408	21.6	No	No	0	6	7
198	R:R:D412	R:R:N410	16.16	No	No	0	4	7
199	R:R:L414	R:R:Q411	7.99	No	Yes	0	9	7
200	R:R:Q411	R:R:V415	4.3	Yes	No	0	7	8
201	R:R:I419	R:R:K416	5.82	No	No	0	5	7
202	R:R:R420	R:R:W497	19.99	No	Yes	0	9	9
203	R:R:I421	R:R:W497	4.7	No	Yes	0	8	9
204	R:R:F496	R:R:V423	5.24	No	No	0	6	6
205	R:R:F424	R:R:P493	7.22	No	Yes	0	9	8
206	R:R:F424	R:R:F496	5.36	No	No	0	9	6
207	R:R:F424	R:R:W497	11.02	No	Yes	0	9	9
208	R:R:I492	R:R:L427	5.71	No	No	1	8	7
209	R:R:L427	R:R:P493	4.93	No	Yes	1	7	8
210	R:R:L432	R:R:Y428	4.69	No	Yes	0	7	8
211	R:R:P493	R:R:Y428	5.56	Yes	Yes	1	8	8
212	R:R:L429	R:R:L433	4.15	No	No	0	7	4
213	R:R:P431	R:R:V430	3.53	No	No	0	9	5
214	R:R:M486	R:R:P431	3.35	No	No	0	7	9
215	R:R:M486	R:R:V434	6.09	No	No	0	7	5
216	R:R:V435	R:R:Y439	5.05	No	Yes	0	7	5
217	R:R:C438	R:R:K483	6.47	No	Yes	0	7	8
218	R:R:K483	R:R:Y439	3.58	Yes	Yes	0	8	5
219	R:R:Y441	R:R:Y445	7.94	No	No	0	9	4
220	R:R:W449	R:R:Y441	8.68	Yes	No	0	9	9
221	R:R:L479	R:R:Y441	8.21	No	No	0	6	9
222	R:R:E442	R:R:R446	4.65	No	No	0	9	6
223	R:R:A444	R:R:Y445	4	No	No	0	3	4
224	R:R:E450	R:R:R446	4.65	No	No	0	6	6
225	R:R:E450	R:R:G447	4.91	No	No	0	6	3
226	R:R:I448	R:R:S473	4.64	No	No	0	3	3
227	R:R:S473	R:R:W449	6.18	No	Yes	0	3	9
228	R:R:P475	R:R:W449	20.27	Yes	Yes	0	8	9
229	R:R:F480	R:R:W449	5.01	No	Yes	0	6	9
230	R:R:R457	R:R:W453	20.99	No	No	0	4	5
231	R:R:I454	R:R:P466	3.39	No	No	0	3	5
232	R:R:P466	R:R:Q455	7.9	No	No	0	5	3
233	R:R:E456	R:R:R457	10.47	No	No	0	4	4
234	R:R:E460	R:R:R457	13.96	No	No	0	3	4
235	R:R:C458	R:R:C465	7.28	No	No	11	9	9
236	R:R:I463	R:R:P464	5.08	No	No	0	5	5
237	R:R:D476	R:R:L479	6.79	No	No	0	5	6
238	R:R:F480	R:R:L479	3.65	No	No	0	6	6
239	R:R:K483	R:R:Y484	8.36	Yes	No	0	8	8
240	R:R:I492	R:R:P493	3.39	No	Yes	1	8	8
241	R:R:C380	R:R:I436	3.27	No	No	0	3	6
242	R:R:F224	R:R:F231	3.22	No	No	0	9	9
243	R:R:V305	R:R:V385	3.21	No	No	0	8	4
244	R:R:S281	R:R:T287	3.2	No	No	0	6	7
245	R:R:T220	R:R:V495	3.17	No	Yes	0	8	8
246	R:R:C361	R:R:L289	3.17	No	No	0	9	7
247	R:R:I338	R:R:S334	3.1	No	No	0	4	5
248	R:R:I404	R:R:V400	3.07	Yes	No	0	7	8
249	R:R:I344	R:R:T343	3.04	No	No	0	7	9
250	R:R:M482	R:R:V434	3.04	No	No	0	6	5
251	R:R:M288	R:R:T287	3.01	No	No	0	5	7
252	R:R:F295	R:R:G340	3.01	Yes	No	0	8	7
253	R:R:F417	R:R:W497	3.01	No	Yes	0	8	9
254	R:R:M472	R:R:T452	3.01	No	No	0	1	5
255	R:R:L379	R:R:S301	3	No	No	0	7	6
256	R:R:L390	R:R:S425	3	No	No	0	8	8
257	R:R:L432	R:R:V383	2.98	No	No	0	7	8
258	R:R:L433	R:R:V383	2.98	No	No	0	4	8
259	R:R:L391	R:R:V387	2.98	No	No	0	4	6
260	R:R:L307	R:R:T310	2.95	No	No	0	9	8
261	R:R:I211	R:R:I212	2.94	No	No	0	3	5
262	R:R:I489	R:R:M486	2.92	No	No	0	5	7
263	R:R:G491	R:R:Y241	2.9	No	Yes	0	9	8
264	R:R:I454	R:R:L180	2.85	No	No	0	3	4
265	R:R:I209	R:R:L488	2.85	Yes	No	0	5	8
266	R:R:I226	R:R:L222	2.85	No	No	0	7	6
267	R:R:I436	R:R:L376	2.85	No	No	0	6	6
268	R:R:I436	R:R:L379	2.85	No	No	0	6	7
269	R:R:I489	R:R:L485	2.85	No	No	0	5	7
270	R:R:L250	R:R:M247	2.83	No	No	0	4	5
271	R:R:K327	R:R:L330	2.82	No	No	0	6	6
272	R:R:C458	R:R:R459	2.79	No	No	11	9	4
273	R:R:C465	R:R:R459	2.79	No	No	11	9	4
274	R:R:H181	R:R:V182	2.77	No	No	0	4	5
275	R:R:D412	R:R:K413	2.77	No	No	0	4	9
276	R:R:P464	R:R:W164	2.7	No	No	0	5	4
277	R:R:E442	R:R:K483	2.7	No	Yes	0	9	8
278	R:R:F231	R:R:T223	2.59	No	No	0	9	9
279	R:R:A315	R:R:W311	2.59	No	Yes	0	8	9
280	R:R:S200	R:R:Y204	2.54	No	No	0	3	4
281	R:R:F256	R:R:I206	2.51	No	No	0	6	7
282	R:R:F374	R:R:I345	2.51	No	No	0	8	4
283	R:R:F221	R:R:L218	2.44	Yes	No	0	7	4
284	R:R:F374	R:R:L342	2.44	No	No	0	8	7
285	R:R:F417	R:R:L397	2.44	No	No	0	8	8
286	R:R:E197	R:R:F201	2.33	No	No	0	4	6
287	R:R:K327	R:R:W319	2.32	No	No	0	6	8
288	R:R:C286	R:R:G354	1.96	No	No	8	9	8
289	R:R:C361	R:R:G354	1.96	No	No	8	9	8
290	R:R:C465	R:R:P466	1.88	No	No	0	9	5
291	R:R:A377	R:R:P378	1.87	No	No	0	4	9
292	R:R:G422	R:R:S425	1.86	No	No	0	7	8
293	R:R:G255	R:R:V360	1.84	No	No	0	8	7
294	R:R:G499	R:R:V498	1.84	No	No	0	7	7
295	R:R:G354	R:R:T278	1.82	No	Yes	0	8	6
296	R:R:G176	R:R:I171	1.76	No	No	0	2	4
297	R:R:G207	R:R:I206	1.76	No	No	0	6	7
298	R:R:C264	R:R:S275	1.72	No	No	0	9	3
299	R:R:A216	R:R:S215	1.71	No	No	0	8	3
300	R:R:A216	R:R:V495	1.7	No	Yes	0	8	8
301	R:R:A263	R:R:V262	1.7	No	No	0	7	6
302	R:R:A285	R:R:V262	1.7	No	No	0	5	6
303	R:R:A487	R:R:V435	1.7	No	No	0	5	7
304	R:R:A263	R:R:T278	1.68	No	Yes	0	7	6
305	R:R:L199	R:R:P190	1.64	No	No	0	6	3
306	R:R:C458	R:R:I463	1.64	No	No	0	9	5
307	R:R:A202	R:R:I357	1.62	No	Yes	0	7	8
308	R:R:A348	R:R:M349	1.61	No	No	0	7	4
309	R:R:V384	R:R:V385	1.6	No	No	0	3	4
310	R:R:V495	R:R:V498	1.6	Yes	No	0	8	7
311	R:R:C264	R:R:D260	1.56	No	No	0	9	6
312	R:R:I426	R:R:V430	1.54	No	No	0	5	5
313	R:R:K318	R:R:V400	1.52	No	No	0	8	8
314	R:R:I448	R:R:T452	1.52	No	No	0	3	5
315	R:R:F440	R:R:G437	1.51	No	No	0	4	5
316	R:R:K284	R:R:T287	1.5	No	No	0	6	7
317	R:R:I209	R:R:I212	1.47	Yes	No	0	5	5
318	R:R:L342	R:R:T341	1.47	No	No	0	7	4
319	R:R:I394	R:R:I395	1.47	No	No	0	7	5
320	R:R:N265	R:R:T278	1.46	No	Yes	0	4	6
321	R:R:D227	R:R:T229	1.45	No	No	0	8	4
322	R:R:P475	R:R:R474	1.44	Yes	No	0	8	4
323	R:R:I254	R:R:L289	1.43	No	No	0	4	7
324	R:R:Q455	R:R:T451	1.42	No	No	0	3	3
325	R:R:P378	R:R:Y382	1.39	No	Yes	0	9	5
326	R:R:E407	R:R:K408	1.35	No	No	0	6	7
327	R:R:F219	R:R:V495	1.31	No	Yes	0	7	8
328	R:R:E409	R:R:N410	1.31	No	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y177	12.7175	4	0	6
2	R:R:P187	8.3425	4	0	5
3	R:R:I209	4.475	4	0	5
4	R:R:T217	6.3475	4	1	8
5	R:R:F221	4.5325	4	0	7
6	R:R:Y233	7.005	6	0	9
7	R:R:F240	9.8475	4	2	8
8	R:R:Y241	6.444	5	1	8
9	R:R:T278	2.3375	4	0	6
10	R:R:F290	6.672	5	4	9
11	R:R:Y294	8.0275	4	4	9
12	R:R:F295	6.838	5	0	8
13	R:R:W303	11.0167	6	2	9
14	R:R:W311	4.095	4	0	9
15	R:R:P339	4.3725	4	0	9
16	R:R:L346	9.1125	4	4	7
17	R:R:I352	5.97	4	0	8
18	R:R:D355	5.916	5	3	9
19	R:R:N356	5.76	4	3	6
20	R:R:I357	5.44	4	3	8
21	R:R:V363	5.4025	4	4	9
22	R:R:D367	5.7925	4	0	6
23	R:R:L371	4.9825	4	9	8
24	R:R:Y382	4.4625	4	0	5
25	R:R:I404	5.04	4	10	7
26	R:R:Q411	10.08	5	10	7
27	R:R:Y428	11.075	4	1	8
28	R:R:Y439	4.594	5	9	5
29	R:R:W449	10.035	4	0	9
30	R:R:P475	7.915	4	0	8
31	R:R:K483	5.2775	4	0	8
32	R:R:P493	5.888	5	1	8
33	R:R:V495	1.945	4	0	8
34	R:R:W497	9.03833	6	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F179	R:R:P188	10.4863	4.33	No	No	0	5	5
2	R:R:F179	R:R:P187	10.4707	13	No	Yes	0	5	5
3	R:R:I171	R:R:Y177	14.9381	12.09	No	Yes	0	4	6
4	R:R:Q279	R:R:Y177	23.9294	24.8	No	Yes	0	7	6
5	R:R:Q279	R:R:S178	13.2368	5.78	No	No	0	7	3
6	R:R:D367	R:R:S178	14.3736	4.42	Yes	No	0	6	3
7	R:R:E353	R:R:Q279	13.2309	5.1	No	No	0	7	7
8	R:R:D367	R:R:E353	14.4223	9.09	Yes	No	0	6	7
9	R:R:F179	R:R:L180	16.69	7.31	No	No	0	5	4
10	R:R:P187	R:R:Y366	11.8508	9.74	Yes	No	0	5	5
11	R:R:M192	R:R:P188	16.5207	5.03	No	No	0	7	5
12	R:R:M192	R:R:N356	38.0149	7.01	No	Yes	0	7	6
13	R:R:N356	R:R:Y366	12.5224	3.49	Yes	No	0	6	5
14	R:R:D355	R:R:N356	45.2854	4.04	Yes	Yes	3	9	6
15	R:R:D355	R:R:L365	47.3098	4.07	Yes	No	0	9	6
16	R:R:F362	R:R:L365	47.7342	3.65	No	No	0	7	6
17	R:R:F362	R:R:Y294	56.2096	7.22	No	Yes	0	7	9
18	R:R:F290	R:R:Y294	35.276	8.25	Yes	Yes	4	9	9
19	R:R:F290	R:R:I352	27.4702	10.05	Yes	Yes	0	9	8
20	R:R:C286	R:R:I352	22.0451	4.91	No	Yes	0	9	8
21	R:R:C286	R:R:G354	14.4398	1.96	No	No	8	9	8
22	R:R:G354	R:R:T278	13.8694	1.82	No	Yes	0	8	6
23	R:R:F362	R:R:V363	21.9555	5.24	No	Yes	0	7	9
24	R:R:F290	R:R:V363	24.1454	5.24	Yes	Yes	4	9	9
25	R:R:M192	R:R:Y193	25.3854	4.79	No	No	0	7	5
26	R:R:P475	R:R:Y193	21.6772	4.17	Yes	No	0	8	5
27	R:R:P475	R:R:W449	10.6128	20.27	Yes	Yes	0	8	9
28	R:R:M298	R:R:Y294	96.7531	10.78	No	Yes	0	7	9
29	R:R:M298	R:R:P339	96.6889	3.35	No	Yes	0	7	9
30	R:R:F295	R:R:P339	100	7.22	Yes	Yes	0	8	9
31	R:R:F295	R:R:F296	67.9787	8.57	Yes	No	0	8	8
32	R:R:C244	R:R:F296	66.4194	4.19	No	No	0	9	8
33	R:R:C244	R:R:G300	65.3605	3.92	No	No	0	9	8
34	R:R:G300	R:R:Y245	64.8252	4.35	No	No	0	8	8
35	R:R:Y241	R:R:Y245	63.7429	5.96	Yes	No	0	8	8
36	R:R:S494	R:R:Y241	32.545	5.09	No	Yes	1	8	8
37	R:R:S494	R:R:T217	28.5447	7.99	No	Yes	1	8	8
38	R:R:M246	R:R:T217	22.5395	4.52	No	Yes	0	5	8
39	R:R:M246	R:R:S249	21.9127	9.2	No	No	0	5	8
40	R:R:C213	R:R:S249	18.5841	3.44	No	No	7	8	8
41	R:R:C213	R:R:L488	17.9027	4.76	No	No	0	8	8
42	R:R:I209	R:R:L488	11.2844	2.85	Yes	No	0	5	8
43	R:R:F295	R:R:W336	68.0741	5.01	Yes	No	0	8	9
44	R:R:W303	R:R:W336	42.9242	14.06	Yes	No	2	9	9
45	R:R:F240	R:R:W303	24.1513	22.05	Yes	Yes	2	8	9
46	R:R:F240	R:R:I239	16.1177	7.54	Yes	No	0	8	8
47	R:R:F224	R:R:I239	14.6656	8.79	No	No	0	9	8
48	R:R:H332	R:R:W336	24.6321	7.41	No	No	2	9	9
49	R:R:F240	R:R:H332	23.9917	3.39	Yes	No	2	8	9
50	R:R:F224	R:R:F231	11.7496	3.22	No	No	0	9	9
51	R:R:F240	R:R:R236	31.6943	6.41	Yes	No	0	8	9
52	R:R:R236	R:R:Y233	30.2986	10.29	No	Yes	0	9	9
53	R:R:I324	R:R:Y233	34.6629	7.25	No	Yes	0	9	9
54	R:R:I306	R:R:W303	17.0579	7.05	No	Yes	2	7	9
55	R:R:F331	R:R:I306	16.4136	3.77	No	No	0	8	7
56	R:R:F331	R:R:Y233	15.0685	7.22	No	Yes	0	8	9
57	R:R:P493	R:R:Y241	29.4168	8.34	Yes	Yes	1	8	8
58	R:R:F424	R:R:P493	27.8771	7.22	No	Yes	0	9	8
59	R:R:F424	R:R:W497	25.582	11.02	No	Yes	0	9	9
60	R:R:L346	R:R:Y294	17.7918	5.86	Yes	Yes	4	7	9
61	R:R:L346	R:R:V363	16.2443	7.45	Yes	Yes	4	7	9
62	R:R:F417	R:R:W497	21.683	3.01	No	Yes	0	8	9
63	R:R:I324	R:R:L313	23.9372	4.28	No	No	0	9	8
64	R:R:F312	R:R:L313	21.7803	3.65	No	No	0	7	8
65	R:R:F312	R:R:V316	15.2865	6.55	No	No	0	7	7
66	R:R:P317	R:R:V316	10.9379	5.3	No	No	0	7	7
67	R:R:G364	R:R:V363	48.5381	3.68	No	Yes	0	8	9
68	R:R:F417	R:R:L397	16.1216	2.44	No	No	0	8	8
69	R:R:L397	R:R:M418	15.3371	7.07	No	No	0	8	8
70	R:R:M418	R:R:R401	12.8494	4.96	No	No	0	8	9
71	R:R:Q411	R:R:R401	11.1753	9.35	Yes	No	0	7	9
72	R:R:I454	R:R:L180	15.1892	2.85	No	No	0	3	4
73	R:R:I454	R:R:P466	13.7156	3.39	No	No	0	3	5
74	R:R:D367	R:R:G364	35.3734	5.03	Yes	No	0	6	8
75	R:R:G364	R:R:L371	15.7557	5.13	No	Yes	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8JHI_nogp

PDB Summary
PDB	8JHI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	303
Number of Links	328
Number of Hubs	34
Number of Links mediated by Hubs	131
Number of Communities	11
Number of Nodes involved in Communities	43
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	88630
Length Of Smallest Path	3
Average Path Length	17.451
Length of Longest Path	37
Minimum Path Strength	1.455
Average Path Strength	6.38276
Maximum Path Strength	18.445
Minimum Path Correlation	0.7
Average Path Correlation	0.94324
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	50.7037
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.9389
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • signaling • canonical Wnt signaling pathway • biological regulation • cell communication • cellular process • signal transduction • Wnt signaling pathway • developmental process • multicellular organismal process • head development • cell population proliferation • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • cell proliferation in midbrain • midbrain development • anatomical structure development • neural precursor cell proliferation • system development • ear morphogenesis • embryonic organ morphogenesis • ear development • sensory organ development • embryonic morphogenesis • embryo development • anatomical structure morphogenesis • sensory organ morphogenesis • inner ear development • inner ear morphogenesis • animal organ morphogenesis • embryonic organ development • non-canonical Wnt signaling pathway • epithelium development • epidermis development • molting cycle process • hair cycle • tissue development • skin development • skin epidermis development • hair follicle development • molting cycle • hair cycle process • sympathetic nervous system development • ganglion development • autonomic nervous system development • sympathetic ganglion development • cellular developmental process • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • neuron migration • motor neuron migration • cell migration • cell motility • regulation of mitotic cell cycle, embryonic • negative regulation of biological process • negative regulation of cell cycle • mitotic cell cycle • negative regulation of mitotic cell cycle • mitotic cell cycle, embryonic • regulation of mitotic cell cycle • negative regulation of cellular process • negative regulation of mitotic cell cycle, embryonic • cell cycle • regulation of cell cycle • commissural neuron axon guidance • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon guidance • axon development • cell morphogenesis involved in neuron differentiation • neuron projection guidance • neuron development • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of execution phase of apoptosis • regulation of programmed cell death • cell death • regulation of execution phase of apoptosis • execution phase of apoptosis • negative regulation of apoptotic process • apoptotic process • programmed cell death • post-anal tail morphogenesis • response to electrical stimulus • response to abiotic stimulus • embryonic epithelial tube formation • chordate embryonic development • tube formation • epithelial tube formation • tube morphogenesis • primary neural tube formation • embryo development ending in birth or egg hatching • epithelial tube morphogenesis • morphogenesis of embryonic epithelium • neural tube development • tube development • morphogenesis of an epithelium • tissue morphogenesis • neural tube closure • neural tube formation • anatomical structure formation involved in morphogenesis • tube closure • Wnt signaling pathway, planar cell polarity pathway • dopaminergic neuron axon guidance • serotonergic neuron axon guidance • brain morphogenesis • midbrain morphogenesis • neuroblast proliferation • positive regulation of nervous system development • positive regulation of cell population proliferation • regulation of developmental process • positive regulation of biological process • regulation of neuroblast proliferation • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of multicellular organismal process • positive regulation of cellular process • regulation of neural precursor cell proliferation • regulation of multicellular organismal development • positive regulation of cell development • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • positive regulation of multicellular organismal process • positive regulation of neuroblast proliferation • establishment of planar polarity • establishment of tissue polarity • morphogenesis of a polarized epithelium • cell periphery • cellular anatomical structure • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cell surface • filopodium tip • cell projection • actin-based cell projection • filopodium • plasma membrane bounded cell projection • somatodendritic compartment
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cell surface • filopodium tip • cell projection • actin-based cell projection • filopodium • plasma membrane bounded cell projection • somatodendritic compartment • dendrite • dendritic tree • neuron projection • intracellular anatomical structure • cytoplasm • synapse • cell junction • glutamatergic synapse • presynaptic active zone membrane • presynaptic membrane • synaptic membrane • presynapse • presynaptic active zone • cell body • neuronal cell body • axon • lateral plasma membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • ionotropic glutamate receptor binding • glutamate receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase activator activity • cation binding • metal ion binding • insulin-like growth factor receptor binding • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NPG1
Sequence	>8JHI_nogp_Chain_R W C P R E L K I D G Y S F L H V R D C S P P C P N M Y F R R E E L S F A R Y F I G L I S I I C L S A T L F T F L T F L I D V T R F R Y P E R P I I F Y A V C Y M M V S L I F F I G F L L E D R V A C N S T V T Q G S H N K A C T M L F M I L Y F F T M A G S V W W V I L T I T W F L A A V P K W G S E A I E K K A L L F H A S A W G I P G T L T I I L L A M N K I E G D N I S G V C F V G L Y D V D A L R Y F V L A P L C L Y V V V G V S L L L G I I S L N R V R I E I P L E K E N Q D K L V K F M I R I G V F S I L Y L V P L L V V I G C Y F Y E Q A Y R G I W E T T W I Q E R C R E Y H I P C P M S R P D L I L F L M K Y L M A L I V G I P S V F W V G S K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHC	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	-	3.3	2024-01-17	doi.org/10.1038/s41421-023-00627-y
	8JHI	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	chim(NtGsXLas-Gs)/β1/γ2	3.2	2024-01-17	doi.org/10.1038/s41421-023-00627-y
	8JHI (No Gprot)	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-		3.2	2024-01-17	doi.org/10.1038/s41421-023-00627-y
	8QW4	F	Protein	Frizzled	FZD₃	Homo sapiens	-	-	-	2.9	2024-09-04	doi.org/10.1038/s41467-024-51451-1

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