Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:K34 5.155409
2A:A:Y37 5.0175419
3A:A:R42 6.02419
4A:A:N50 6.384179
5A:A:F212 5.868509
6A:A:F219 7.19167688
7A:A:H220 5.766517
8A:A:F222 10.42417
9A:A:Q227 6.74409
10A:A:E230 7.73419
11A:A:K233 5.636519
12A:A:W234 5.3565159
13A:A:F238 8.945159
14A:A:Y253 6.8265218
15A:A:R265 10.094179
16A:A:F273 5.53833649
17A:A:W277 11.1025446
18A:A:W281 14.965415
19A:A:F290 5.01754189
20A:A:F315 11.89406
21A:A:P321 4.40754125
22A:A:E330 4.4925223
23A:A:V334 4.8425404
24A:A:Y339 7.4325443
25A:A:F340 8.80254127
26A:A:R342 6.7325444
27A:A:E344 5.575125
28A:A:F345 8.215448
29A:A:L346 4.8125444
30A:A:R356 4.9254232
31A:A:Y360 9.60254248
32A:A:F363 7.84545
33A:A:F376 7.87667688
34A:A:I383 4.14488
35B:B:L7 7.74258
36B:B:T34 3.73405
37B:B:I37 3.084502
38B:B:H54 7.786119
39B:B:L55 5.6075406
40B:B:K57 9419
41B:B:Y59 8.17667618
42B:B:M61 4.9275456
43B:B:W63 8.796557
44B:B:S72 4.90754119
45B:B:Q75 8.9225419
46B:B:I80 8.34754118
47B:B:W82 8.9856119
48B:B:Y85 7.7675454
49B:B:K89 4.7945119
50B:B:H91 5.8225405
51B:B:L95 3.99254168
52B:B:W99 10.8409
53B:B:M101 4.78419
54B:B:N110 6.794284
55B:B:C114 4.98254168
56B:B:Y124 5.4356166
57B:B:H142 8.198599
58B:B:Y145 5.26667618
59B:B:F151 4.368509
60B:B:T159 5.542599
61B:B:T165 5.8725497
62B:B:W169 10.464598
63B:B:Q176 6.1925494
64B:B:F180 7.4325467
65B:B:H183 8.91833669
66B:B:D186 5.005419
67B:B:V187 4.638569
68B:B:L190 4.5575405
69B:B:F199 6.87469
70B:B:S201 4.915469
71B:B:C204 5.122517
72B:B:S207 5.485465
73B:B:K209 9.494566
74B:B:L210 5.388525
75B:B:W211 8.19833668
76B:B:M217 5.9375423
77B:B:R219 6.6575425
78B:B:Q220 7.485427
79B:B:H225 8.91714729
80B:B:I232 5.4775408
81B:B:F235 7.068336196
82B:B:F241 6.90833626
83B:B:T243 6.2775428
84B:B:D247 10.488529
85B:B:T249 8.4075426
86B:B:R251 8.968528
87B:B:F253 7.866526
88B:B:Q259 4.37406
89B:B:Y264 5.39667605
90B:B:C271 4.22415
91B:B:Y289 7.19717
92B:B:D290 8.625416
93B:B:D291 5.54418
94B:B:C294 4.085475
95B:B:N295 7.585416
96B:B:V296 3.1425405
97B:B:L300 3.81406
98B:B:K301 5.2954305
99B:B:R304 4.5415
100B:B:H311 7.81579
101B:B:R314 14.218518
102B:B:T329 6.55578
103B:B:W332 9.735619
104B:B:D333 8.01479
105B:B:K337 7.6625476
106B:B:W339 8.25167679
107G:G:Q11 5.066503
108G:G:E22 5.324269
109G:G:Y40 12.744196
110G:G:D48 7.6954139
111G:G:L51 5.3145136
112G:G:F61 5.38833658
113R:R:Y177 12.7175407
114R:R:P187 8.3425405
115R:R:I209 4.475406
116R:R:T217 6.34754108
117R:R:F221 4.5325405
118R:R:Y233 7.005609
119R:R:F240 9.84754147
120R:R:Y241 6.4445107
121R:R:T278 2.3375405
122R:R:Q279 9.7425408
123R:R:T287 2.6875437
124R:R:F290 6.672539
125R:R:Y294 8.0275439
126R:R:F295 6.838508
127R:R:W303 11.01676149
128R:R:W311 4.095409
129R:R:P339 4.3725408
130R:R:L346 9.1125436
131R:R:I352 5.384538
132R:R:D355 5.9165209
133R:R:N356 5.764207
134R:R:I357 5.444207
135R:R:V363 5.4025438
136R:R:G364 4.2775439
137R:R:D367 5.7925437
138R:R:L371 4.9825438
139R:R:Y382 4.4625405
140R:R:V400 2.2375408
141R:R:I404 5.044347
142R:R:Q411 10.085346
143R:R:M418 4.86408
144R:R:Y428 11.0754107
145R:R:Y439 4.594534
146R:R:W449 10.035409
147R:R:P475 7.915408
148R:R:K483 5.2775408
149R:R:P493 5.8885107
150R:R:S494 4.565108
151R:R:V495 1.945407
152R:R:W497 9.03833609
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:Y85 G:G:P60 16.68999.74YesNo049
2B:B:M325 G:G:P60 17.2286.71NoNo059
3B:B:M325 G:G:P49 23.14913.35NoNo057
4G:G:D48 G:G:P49 24.76296.44YesNo097
5G:G:D48 G:G:L51 26.37658.14YesYes1396
6B:B:R283 G:G:L51 30.1419.72NoYes096
7B:B:I37 B:B:R283 15.34123.76YesNo029
8B:B:I37 B:B:T34 17.75793.04YesYes025
9B:B:L30 B:B:T34 34.43684.42NoYes055
10B:B:L30 B:B:M262 34.97254.24NoNo054
11B:B:M262 B:B:Y264 36.31148.38NoYes045
12B:B:W297 B:B:Y264 44.86026.75NoYes085
13B:B:W297 B:B:Y289 45.11956.75NoYes187
14B:B:C271 B:B:Y289 49.13454.03YesYes157
15B:B:C271 B:B:D290 51.27893.11YesYes156
16B:B:D290 B:B:R314 51.480216.68YesYes168
17B:B:R314 B:B:W332 61.664822.99YesYes189
18B:B:K57 B:B:W332 15.299612.76YesYes199
19B:B:L300 B:B:R283 15.3386.07YesNo069
20B:B:L300 B:B:T34 16.14364.42YesYes065
21B:B:K57 B:B:Q75 15.32656.78YesYes199
22B:B:W332 B:B:Y59 47.42738.68YesYes198
23B:B:Q75 B:B:Y59 15.327818.04YesYes198
24A:A:F290 A:A:I56 99.2633.77YesNo097
25A:A:I56 A:A:V247 99.30633.07NoNo077
26A:A:N292 A:A:V247 99.60824.43NoNo097
27A:A:K293 A:A:N292 99.69435.6NoNo099
28A:A:D249 A:A:K293 49.869215.21NoNo089
29A:A:D249 A:A:S251 49.83185.89NoNo089
30A:A:K300 A:A:S251 99.80674.59NoNo099
31A:A:K300 A:A:Y253 99.77319.55NoYes2198
32A:A:I308 A:A:Y253 1006.04NoYes078
33A:A:F315 A:A:I308 99.997715.07YesNo067
34A:A:F315 A:A:F340 99.557912.86YesYes067
35A:A:E344 A:A:F340 99.59193.5YesYes1257
36A:A:E344 A:A:L270 99.66135.3YesNo056
37A:A:F345 A:A:L270 99.65149.74YesNo086
38A:A:F345 A:A:V248 49.60077.87YesNo087
39A:A:F246 A:A:V248 49.56483.93NoNo097
40A:A:F246 A:A:L272 99.42067.31NoNo098
41A:A:L272 A:A:R231 99.32038.5NoNo089
42A:A:R231 A:A:W234 99.0779NoYes1599
43A:A:Q227 A:A:W234 62.57846.57YesYes099
44A:A:Q227 B:B:L117 16.76725.32YesNo099
45A:A:C237 B:B:L117 16.30773.17NoNo089
46A:A:C237 B:B:Y59 16.24125.38NoYes188
47A:A:K293 A:A:L296 49.86925.64NoNo096
48A:A:L296 A:A:S251 49.97814.5NoNo069
49A:A:F273 A:A:F345 49.88884.29YesYes498
50A:A:F246 A:A:F273 49.90645.36NoYes099
51A:A:Q227 B:B:Y145 17.95914.51YesYes098
52B:B:M101 B:B:Y145 16.50717.18YesYes198
53B:B:M101 B:B:Y59 16.30923.59YesYes198
54A:A:F238 A:A:W234 36.4174.01YesYes1599
55A:A:F238 B:B:W99 36.108512.03YesYes099
56B:B:Q75 B:B:W99 33.4196.57YesYes099
57A:A:Q227 B:B:N119 32.945510.56YesNo099
58A:A:D378 A:A:H362 97.281513.87NoNo079
59A:A:H362 A:A:R374 97.392110.16NoNo094
60A:A:E370 A:A:R374 97.502715.12NoNo044
61A:A:D368 A:A:E370 97.613312.99NoNo094
62A:A:D368 A:A:T364 48.86194.34NoNo1899
63A:A:F290 A:A:T364 48.91346.49YesNo1899
64A:A:D368 A:A:N371 48.861913.46NoNo1899
65A:A:F290 A:A:N371 48.91346.04YesNo1899
66A:A:D378 A:A:Y360 96.949511.49NoYes078
67A:A:R385 A:A:Y358 96.39596.17NoNo054
68A:A:R385 A:A:Y360 96.49929.26NoYes2458
69A:A:Y358 R:R:K408 95.625.97NoNo044
70R:R:E409 R:R:K408 95.398221.6NoNo054
71R:R:E409 R:R:I404 95.28735.47NoYes057
72R:R:I404 R:R:Q411 94.61388.23YesYes3476
73R:R:L414 R:R:Q411 93.2877.99NoYes086
74A:A:L393 R:R:L414 92.6194.15NoNo088
75A:A:L393 R:R:F417 92.507617.05NoNo088
76R:R:F417 R:R:W497 91.72723.01NoYes089
77R:R:I238 R:R:W497 47.12533.52NoYes089
78R:R:I238 R:R:S494 47.01043.1NoYes088
79R:R:S494 R:R:Y241 42.39795.09YesYes1087
80R:R:Y241 R:R:Y245 84.23245.96YesNo077
81R:R:G300 R:R:Y245 83.7634.35NoNo087
82R:R:C244 R:R:G300 83.52833.92NoNo098
83R:R:C244 R:R:F296 83.05884.19NoNo098
84R:R:F295 R:R:F296 82.35438.57YesNo088
85R:R:F295 R:R:W336 24.02835.01YesNo089
86R:R:W303 R:R:W336 15.138414.06YesNo1499
87R:R:F240 R:R:R236 11.05696.41YesNo079
88R:R:R236 R:R:Y233 10.576410.29NoYes099
89R:R:I324 R:R:Y233 12.25917.25NoYes089
90R:R:F424 R:R:W497 44.157811.02NoYes089
91R:R:F424 R:R:P493 43.81197.22NoYes087
92R:R:P493 R:R:Y241 42.27948.34YesYes1077
93B:B:G144 B:B:N119 32.68293.39NoNo089
94B:B:G144 B:B:T143 32.61723.64NoNo085
95B:B:D163 B:B:T143 32.551510.12NoNo095
96B:B:D163 B:B:S161 16.03287.36NoNo999
97B:B:H142 B:B:S161 15.964916.74YesNo999
98B:B:H142 B:B:T159 30.67555.48YesYes999
99B:B:C149 B:B:T159 27.64085.07NoYes089
100B:B:C149 B:B:T102 27.50223.38NoNo088
101B:B:C148 B:B:T102 27.22523.38NoNo068
102B:B:C148 B:B:L190 26.54133.17NoYes065
103B:B:F199 B:B:L190 24.58156.09YesYes095
104B:B:F180 B:B:F199 22.47767.5YesYes679
105B:B:F180 B:B:T178 22.2335.19YesNo074
106B:B:T177 B:B:T178 22.09384.71NoNo044
107B:B:L168 B:B:T177 21.95454.42NoNo064
108B:B:L168 B:B:V213 20.72.98NoNo064
109B:B:R214 B:B:V213 20.56065.23NoNo094
110B:B:E215 B:B:R214 19.72343.49NoNo039
111B:B:Q220 B:B:R219 13.24544.67YesYes275
112B:B:D163 B:B:T165 16.452913.01NoYes997
113B:B:H142 B:B:T165 15.96914.11YesYes997
114R:R:F295 R:R:P339 57.83227.22YesYes088
115R:R:M298 R:R:P339 53.0723.35NoYes078
116R:R:M298 R:R:Y294 51.168510.78NoYes079
117R:R:F362 R:R:Y294 28.00297.22NoYes079
118R:R:F362 R:R:L365 20.38133.65NoNo077
119R:R:D355 R:R:L365 20.14214.07YesNo097
120R:R:D355 R:R:N356 17.28474.04YesYes2097
121R:R:M192 R:R:N356 12.98347.01NoYes067
122R:R:F290 R:R:Y294 14.36888.25YesYes399
123R:R:G364 R:R:V363 21.5423.68YesYes398
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8JHI
Class F
SubFamily Protein
Type Frizzled
SubType FZD3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGsXLas-Gs)/Beta1/Gamma2
PDB Resolution 3.2
Date 2024-01-17 
D.O.I. 10.1038/s41421-023-00627-y
Net Summary
Imin 3.01
Number of Linked Nodes 904
Number of Links 1054
Number of Hubs 152
Number of Links mediated by Hubs 558
Number of Communities 35
Number of Nodes involved in Communities 242
Number of Links involved in Communities 325
Path Summary
Number Of Nodes in MetaPath 124
Number Of Links MetaPath 123
Number of Shortest Paths 11712461
Length Of Smallest Path 3
Average Path Length 63.0841
Length of Longest Path 95
Minimum Path Strength 1.295
Average Path Strength 7.88578
Maximum Path Strength 20.99
Minimum Path Correlation 0.7
Average Path Correlation 0.998065
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.78571
Average % Of Corr. Nodes 28.3699
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.2976
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8JHI_Chain_A
NSKTEDKRA QKRAEKKRS KLIDKQLQD EKMGYMCTH RLLLLGADN 
SGKSTIVKQ MRGIFETKF QVDKVNFHM FDVGGQRDE RRKWIQCFN 
DVTAIIFVV DSSDYNRLQ EALNLFKSI WNNRWLRTI SVILFLNKQ 
DLLAEKVLA GKSKIEDYF PEFARYTTP EDATPEPGE DPRVTRAKY 
FIRDEFLRI STASGDGRH YCYPHFTCA VDTENARRI FNDCRDIIQ 
RMHLRQYEL L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8JHI_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8JHI_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9NPG1
Sequence
>8JHI_Chain_R
WCPRELKID GYSFLHVRD CSPPCPNMY FRREELSFA RYFIGLISI 
ICLSATLFT FLTFLIDVT RFRYPERPI IFYAVCYMM VSLIFFIGF 
LLEDRVACN STVTQGSHN KACTMLFMI LYFFTMAGS VWWVILTIT 
WFLAAVPKW GSEAIEKKA LLFHASAWG IPGTLTIIL LAMNKIEGD 
NISGVCFVG LYDVDALRY FVLAPLCLY VVVGVSLLL GIISLNRVR 
IEIPLEKEN QDKLVKFMI RIGVFSILY LVPLLVVIG CYFYEQAYR 
GIWETTWIQ ERCREYHIP CPMSRPDLI LFLMKYLMA LIVGIPSVF 
WVGSKK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JHCFProteinFrizzledFZD3Homo sapiens---3.32024-01-1710.1038/s41421-023-00627-y




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JHI.zip



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