Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 6.366524
2A:A:L45 4.8245128
3A:A:K53 4.423336129
4A:A:F219 6.11408
5A:A:F222 8.12754197
6A:A:Q227 6.116519
7A:A:R228 4.8125419
8A:A:K233 4.858519
9A:A:W234 4.47619
10A:A:F238 6.4025409
11A:A:I244 2.21754208
12A:A:L270 5.195406
13A:A:W277 9.87406
14A:A:W281 9.996555
15A:A:I288 4.61409
16A:A:F290 4.88409
17A:A:N292 3.61409
18A:A:F315 8.2875406
19A:A:P328 5.2125401
20A:A:V334 2.4675404
21A:A:F340 9.205407
22A:A:R342 6.0475494
23A:A:E344 6.905405
24A:A:F345 7.1825408
25A:A:Y360 7.155408
26A:A:F363 4.35595
27A:A:T364 5.30754219
28A:A:D368 4.5685219
29A:A:N371 5.56254219
30A:A:F376 4.2865228
31A:A:Y391 6.012534
32B:B:L4 3.01404
33B:B:I18 2.7925407
34B:B:I37 4.53754102
35B:B:V40 4.3645103
36B:B:M45 3.1975404
37B:B:H54 9.074529
38B:B:L55 7.48254186
39B:B:K57 7.996559
40B:B:Y59 9.245458
41B:B:W63 5.802507
42B:B:Q75 7.65459
43B:B:D76 6.335409
44B:B:I80 7.015428
45B:B:W82 7.93429729
46B:B:D83 8.2775428
47B:B:K89 5.45857729
48B:B:I93 4.6045117
49B:B:L95 3.4554118
50B:B:W99 6.88833609
51B:B:Y105 4.795406
52B:B:N110 5.1454254
53B:B:Y111 6.0425404
54B:B:L117 4.6725419
55B:B:Y124 4.558336116
56B:B:V133 4.2654114
57B:B:H142 6.60833619
58B:B:Y145 5.445818
59B:B:F151 4.27667619
60B:B:T159 5.4425419
61B:B:D163 7.385419
62B:B:W169 8.22833618
63B:B:F180 7.2575467
64B:B:H183 6.71569
65B:B:F199 6.2225469
66B:B:C204 5.22417
67B:B:K209 8.634566
68B:B:L210 3.305405
69B:B:W211 7.82833668
70B:B:Q220 6.03447
71B:B:F222 6.7575448
72B:B:H225 8.11167649
73B:B:D228 9.29419
74B:B:I232 4.088508
75B:B:F235 6.5585146
76B:B:P236 5.30754147
77B:B:N237 5.995405
78B:B:T243 5.5925448
79B:B:D247 6.5025449
80B:B:R251 8.204548
81B:B:F253 5.596546
82B:B:D254 3.6775409
83B:B:D258 8.84447
84B:B:L261 2.8075405
85B:B:M262 4.995404
86B:B:Y264 6.2375405
87B:B:F278 4.8025147
88B:B:R283 6.8725109
89B:B:L284 4.3375405
90B:B:Y289 6.203336157
91B:B:D290 6.038556
92B:B:C294 3.845405
93B:B:N295 7.29254156
94B:B:W297 4.50754158
95B:B:L300 5.284106
96B:B:K301 5.4025405
97B:B:H311 8.7425479
98B:B:R314 11.86558
99B:B:L318 3.622506
100B:B:V320 2.935407
101B:B:V327 3.2125406
102B:B:W332 8.93571759
103B:B:F335 4.305474
104B:B:L336 4.82427
105B:B:K337 7.025476
106B:B:W339 6.20667679
107G:G:L19 2.7925409
108G:G:R27 4.465408
109G:G:D48 6.654509
110G:G:L51 4.655106
111G:G:P60 5.99754139
112G:G:F61 4.916138
113R:R:F13 3.8665169
114R:R:I18 3.9685265
115R:R:Y36 5.755409
116R:R:N43 4.425409
117R:R:I46 3.1475408
118R:R:I49 2.7275405
119R:R:L56 4.8325439
120R:R:M60 4.7675439
121R:R:Y61 5.578539
122R:R:Y62 5.16406
123R:R:F95 4.8554164
124R:R:F99 5.92754164
125R:R:M102 3.895405
126R:R:F103 4.345405
127R:R:M111 4.67754275
128R:R:E112 5.4225179
129R:R:D122 6.6439
130R:R:R123 5.46439
131R:R:Y133 5.62439
132R:R:F154 4.58254272
133R:R:I157 5.1775405
134R:R:L160 4.6325404
135R:R:Y169 4.461676165
136R:R:H177 7.294588
137R:R:Y179 4.83857705
138R:R:H182 5.1825405
139R:R:M186 4.11754305
140R:R:Y199 5.5275403
141R:R:D211 8.8954286
142R:R:Y219 5.035639
143R:R:H245 5.17439
144R:R:Y253 6.8525286
145R:R:M256 7.15403
146R:R:H263 8.38587
147R:R:R264 6.0185304
148R:R:V269 4.382582
149R:R:M277 2.325405
150R:R:L282 4.748507
151R:R:N289 6.114179
152R:R:Y293 4.658509
153R:R:R303 7.71714708
154R:R:I304 2.105405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:S74 11.761312.55YesNo099
2B:B:D76 B:B:S74 11.90275.89YesNo099
3B:B:D76 B:B:L55 12.937412.21YesYes096
4A:A:Y37 B:B:L55 13.54657.03NoYes046
5A:A:R42 A:A:Y37 13.699517.49NoNo094
6A:A:F222 A:A:R42 14.16644.28YesNo079
7A:A:F222 B:B:W99 14.899710.02YesYes079
8A:A:F238 B:B:W99 84.16789.02YesYes099
9A:A:F238 A:A:W234 80.023.01YesYes099
10A:A:R231 A:A:W234 88.8574NoYes099
11A:A:L272 A:A:R231 88.90273.64NoNo089
12A:A:F246 A:A:L272 89.33136.09NoNo098
13A:A:F246 A:A:L289 89.37873.65NoNo099
14A:A:L289 A:A:L291 93.17775.54NoNo098
15A:A:F363 A:A:L291 99.08866.09YesNo058
16A:A:F363 A:A:Q294 98.31433.51YesNo956
17A:A:Q294 A:A:S250 98.45294.33NoNo066
18A:A:L297 A:A:S250 98.48596.01NoNo086
19A:A:L297 A:A:S251 99.63573NoNo089
20A:A:D249 A:A:S251 99.75965.89NoNo089
21A:A:D249 A:A:K293 99.94089.68NoNo089
22A:A:K293 A:A:N292 1002.8NoYes099
23A:A:I56 A:A:N292 48.29492.83NoYes079
24A:A:I56 A:A:N371 48.24522.83NoYes079
25A:A:M60 A:A:N371 96.66132.8NoYes099
26A:A:F212 A:A:M60 96.55583.73NoNo099
27A:A:F212 A:A:F219 96.34511.79NoYes098
28A:A:N292 A:A:T364 51.37815.85YesYes099
29A:A:N371 A:A:T364 48.32945.85YesYes2199
30A:A:F219 A:A:H41 94.25864.53YesNo086
31A:A:H41 R:R:L131 94.15233.86NoNo069
32B:B:L318 B:B:S275 24.02756.01YesNo068
33B:B:S275 B:B:T274 24.2943.2NoNo088
34B:B:R314 B:B:T274 24.4495.17YesNo588
35A:A:W281 B:B:D290 18.32055.58YesYes556
36B:B:Q75 B:B:W99 64.10765.48YesYes099
37B:B:Q75 B:B:Y59 31.791812.4YesYes598
38B:B:R314 B:B:W332 43.252118.99YesYes589
39B:B:K57 B:B:Q75 32.07188.14YesYes599
40A:A:F345 A:A:L270 10.29368.53YesYes086
41A:A:I383 R:R:L131 94.11354.28NoNo089
42A:A:H387 A:A:I383 95.14933.98NoNo088
43A:A:H387 R:R:Y133 95.04034.36NoYes089
44R:R:D122 R:R:Y133 48.24975.75YesYes399
45A:A:Y391 R:R:D122 46.62818.05YesYes349
46A:A:Y391 R:R:R123 84.06356.17YesYes349
47R:R:H245 R:R:R123 24.97286.77YesYes399
48R:R:A126 R:R:Y133 46.52655.34NoYes099
49A:A:Y391 R:R:A126 46.39315.34YesNo049
50B:B:S97 B:B:W99 23.42863.71NoYes089
51B:B:D118 B:B:S97 23.27088.83NoNo098
52B:B:D118 B:B:I120 23.11294.2NoNo096
53B:B:E138 B:B:I120 22.63826.83NoNo066
54B:B:E138 B:B:S122 22.47972.87NoNo068
55B:B:S122 B:B:Y124 22.3216.36NoYes086
56B:B:I93 B:B:Y124 20.33864.84YesYes1176
57B:B:I81 B:B:I93 19.90422.94NoYes077
58B:B:I81 B:B:V71 19.77884.61NoNo078
59B:B:V71 B:B:Y105 19.13187.57NoYes086
60B:B:H62 B:B:Y105 18.6454.36NoYes066
61B:B:H62 B:B:R150 18.48249.03NoNo066
62B:B:C148 B:B:R150 18.31964.18NoNo066
63B:B:C148 B:B:L190 18.15674.76NoNo065
64B:B:L190 B:B:S160 17.99363NoNo056
65B:B:S160 B:B:V187 17.83046.46NoNo069
66B:B:H183 B:B:V187 17.50355.54YesNo099
67B:B:H183 B:B:K209 14.262310.48YesYes696
68B:B:K209 B:B:T221 13.35813.51YesNo067
69B:B:T221 G:G:E22 13.19048.47NoNo079
70B:B:I18 G:G:E22 13.02282.73YesNo079
71B:B:L284 B:B:V296 11.82935.96YesNo055
72B:B:W297 B:B:Y264 22.6084.82YesYes085
73B:B:C271 B:B:D290 35.57993.11NoYes056
74B:B:D291 B:B:Y289 33.40434.6NoYes087
75B:B:C271 B:B:D291 35.02886.22NoNo058
76B:B:L286 B:B:V296 11.66692.98NoNo075
77B:B:L286 B:B:V327 11.92582.98NoYes076
78R:R:R123 R:R:Y219 58.4995.14YesYes399
79R:R:V249 R:R:Y219 55.95342.52NoYes089
80R:R:V249 R:R:Y253 55.64812.52NoYes086
81R:R:M256 R:R:Y253 54.50133.59YesYes036
82R:R:M208 R:R:M256 23.60724.33NoYes023
83R:R:F110 R:R:M208 23.2837.46NoNo022
84R:R:F110 R:R:I157 21.32448.79NoYes025
85R:R:I157 R:R:L160 16.83892.85YesYes054
86R:R:H182 R:R:L160 12.65847.71YesYes054
87R:R:H245 R:R:Y293 18.1784.36YesYes099
88R:R:N289 R:R:Y293 11.59666.98YesYes099
89R:R:M256 R:R:Y281 30.591611.97YesNo037
90R:R:L282 R:R:Y281 20.77268.21YesNo077
91R:R:L282 R:R:Y179 16.50327.03YesYes075
92B:B:W332 B:B:Y59 31.69039.65YesYes598
93B:B:K57 B:B:W332 31.690613.92YesYes599
94A:A:W281 B:B:W332 19.11783.75YesYes559
95B:B:D290 B:B:R314 18.29715.48YesYes568
96B:B:W297 B:B:Y289 24.09854.82YesYes1587
97B:B:L318 B:B:V327 14.46222.98YesYes066
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8UXV
Class O1
SubFamily Odorant receptors
Type Odorant family 51
SubType consOR51
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.2
Date 2024-10-30 
D.O.I. doi.org/10.1038/s41586-024-08126-0
Net Summary
Imin 2.8
Number of Linked Nodes 855
Number of Links 991
Number of Hubs 154
Number of Links mediated by Hubs 570
Number of Communities 30
Number of Nodes involved in Communities 188
Number of Links involved in Communities 246
Path Summary
Number Of Nodes in MetaPath 98
Number Of Links MetaPath 97
Number of Shortest Paths 1705911
Length Of Smallest Path 3
Average Path Length 39.6484
Length of Longest Path 76
Minimum Path Strength 1.26
Average Path Strength 5.59021
Maximum Path Strength 17.235
Minimum Path Correlation 0.7
Average Path Correlation 0.985331
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 33.9609
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.6298
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8UXV_Chain_A
NEEKAQREA NKKIEKQLQ KDKQVYRAT HRLLLLGAS GKSTIVKQM 
RGIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND VTAIIFVVS 
SYNRLQEAL NLFKSIWNN RWLRTISVI LFLNKQDLL AEKVLAGKS 
KIEDYFPEF ARYTTPPGE DPRVTRAKY FIRDEFLRI STASGDGRH 
YCYPHFTCA VDTENRRFN DCRDIIQRM HLRQYELLD NDDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8UXV_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8UXV_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtCons
Sequence
>8UXV_Chain_R
SCATFLLTG PGLEAAHIW SPFCFMYIA LGNGTILFI IRTEPLHEP 
MYYFMLAAT DLGLSLSTL PTVLGIFWF NREISFNAC FAQMFFIHG 
FSFMESSLL AMAFDRFVA ICPLRYASI TNTRVAKIG LAITRSFLL 
ILPLPFLLK RLPHSNVLS HSYLHQDVM KLACADIRF NSIYGLFVV 
LSTMGLDSL ILFSYILIL KTVLGIASR EERLKLNTC VSHICAVLV 
FYVPMIGLS LHRFGKHVP PVVHVLMAV YLLVPPVMN PIIYSVKTK 
QIRKRILRL FSLIIILIL SAVNLLYCL AVN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UXVO1Odorant receptorsOdorant family 51consOR51Homo sapiens--Gs/β1/γ23.22024-10-30doi.org/10.1038/s41586-024-08126-0
8UXV (No Gprot) O1Odorant receptorsOdorant family 51consOR51Homo sapiens--3.22024-10-30doi.org/10.1038/s41586-024-08126-0




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8UXV.zip



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