Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 4.3425406
2A:A:R42 6.1025409
3A:A:V214 3.3875486
4A:A:F219 5.452588
5A:A:F222 8.9925417
6A:A:Q227 3.9975419
7A:A:K233 5.1525419
8A:A:W234 4.095419
9A:A:C237 3.6825418
10A:A:F238 3.52833619
11A:A:D252 5.51254208
12A:A:Y253 6.6425108
13A:A:F273 4.274559
14A:A:W277 7.47556
15A:A:W281 4.4425415
16A:A:I288 4.6275499
17A:A:F290 3.715699
18A:A:L291 3.225458
19A:A:N292 4.6625409
20A:A:Q294 3.12556
21A:A:I308 3.865107
22A:A:Y311 10.0025406
23A:A:F312 3.0145108
24A:A:Y318 5.085406
25A:A:P328 3.9175401
26A:A:F340 7.0445107
27A:A:R342 5.9075454
28A:A:F345 4.8558
29A:A:R356 5.1525402
30A:A:F363 4.566555
31A:A:T364 5.018599
32A:A:N371 4.0425499
33A:A:R373 4.74485
34A:A:R374 5.55494
35A:A:F376 3.155688
36A:A:Y391 5.51504
37A:A:L393 2.94228
38B:B:I18 3.844507
39B:B:L30 3.2375405
40B:B:I37 2.77254152
41B:B:V40 3.661676153
42B:B:L51 5.7025439
43B:B:H54 7.865439
44B:B:K57 10.16519
45B:B:Y59 8.305418
46B:B:M61 3.215436
47B:B:W63 6.37833637
48B:B:Q75 8.79419
49B:B:D76 6.365409
50B:B:K78 4.25408
51B:B:I80 5.47438
52B:B:W82 6.74833639
53B:B:N88 9.2625407
54B:B:K89 5.014539
55B:B:I93 4.99407
56B:B:L95 4.022578
57B:B:W99 4.435619
58B:B:V100 3.28479
59B:B:Y105 3.615606
60B:B:Y111 3.982504
61B:B:C114 3.3275478
62B:B:G115 1.9325479
63B:B:H142 6.824519
64B:B:Y145 3.22833618
65B:B:C148 3.045446
66B:B:F151 3.385259
67B:B:L152 3.386543
68B:B:T159 4.795419
69B:B:S160 3.554546
70B:B:S161 3.96519
71B:B:C166 3.1925448
72B:B:W169 8.142518
73B:B:F180 5.9475447
74B:B:H183 6.362549
75B:B:D186 3.9675419
76B:B:V187 3.9125449
77B:B:L190 3.135445
78B:B:F199 4.66449
79B:B:S201 2.9449
80B:B:K209 8.02546
81B:B:L210 3.816515
82B:B:W211 6.41648
83B:B:Q220 4.562517
84B:B:F222 4.564518
85B:B:H225 7.83667619
86B:B:D228 5.584519
87B:B:I232 4.8775408
88B:B:F235 6.568577166
89B:B:P236 5.66754167
90B:B:F241 6.5575416
91B:B:T243 4.38518
92B:B:T249 5.41416
93B:B:C250 2.288518
94B:B:R251 9.53518
95B:B:F253 3.91167616
96B:B:D258 6.42517
97B:B:Y264 4.61505
98B:B:I269 3.3875414
99B:B:I273 4.53416
100B:B:F278 4.9054167
101B:B:R283 6.1365159
102B:B:Y289 5.55167617
103B:B:N295 7.3625416
104B:B:W297 3.864518
105B:B:L300 3.66754156
106B:B:K301 4.205405
107B:B:R304 5.25415
108B:B:H311 6.2265119
109B:B:R314 6.132518
110B:B:T321 6.2675437
111B:B:W332 6.88286719
112B:B:D333 7.72254119
113B:B:L336 3.026537
114B:B:K337 4.52754116
115B:B:I338 2.8475435
116B:B:W339 5.2645119
117G:G:L15 2.08254232
118G:G:R27 5.852518
119G:G:Y40 6.80254166
120G:G:D48 5.34754249
121G:G:L50 3.63254249
122G:G:L51 3.235406
123G:G:F61 3.12167638
124L:L:?1 5.6791020
125R:R:F12 4.3525129
126R:R:L13 4.4654126
127R:R:Q20 5.084272
128R:R:F31 4.794526
129R:R:Y35 4.636529
130R:R:N42 5.612509
131R:R:I49 4.38754287
132R:R:Y60 5.235717289
133R:R:F62 3.267147137
134R:R:L66 4.1125469
135R:R:D70 5.365469
136R:R:V78 3.05425
137R:R:Y94 2.81254124
138R:R:Y102 4.392505
139R:R:F103 3.4254295
140R:R:F104 5.145625
141R:R:F107 5.24254294
142R:R:N109 5.75523
143R:R:L110 4.4925465
144R:R:D111 4.7475468
145R:R:F113 2.84523
146R:R:L114 3.8475467
147R:R:D121 4.51254139
148R:R:Y123 4.5825407
149R:R:I126 2.92754229
150R:R:P129 4.5885149
151R:R:Y132 5.31254139
152R:R:M136 3.894139
153R:R:H155 9.306523
154R:R:H159 4.6625424
155R:R:I174 3.142508
156R:R:H176 6.16571728
157R:R:F177 8.158527
158R:R:F178 6.705626
159R:R:D180 5.1428
160R:R:P183 4.1875426
161R:R:L184 2.8225406
162R:R:L185 3.16754176
163R:R:T192 3.5445176
164R:R:N195 3.824175
165R:R:E202 7.875402
166R:R:P210 2.92526
167R:R:I228 2.2325406
168R:R:H244 5.844569
169R:R:Y252 4.42857726
170R:R:Y259 7.81428
171R:R:Y266 5.872522
172R:R:D270 5.9675405
173R:R:Y277 5.56627
174R:R:N285 4.3725469
175R:R:I288 3.4925469
176R:R:Y289 3.21333669
177R:R:M296 3.3125407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:S316 15.85243.44NoNo079
2B:B:S316 B:B:W332 16.05264.94NoYes099
3B:B:W332 B:B:Y59 68.70763.86YesYes198
4A:A:C237 B:B:Y59 67.91144.03YesYes188
5A:A:C237 A:A:F238 76.63362.79YesYes189
6A:A:F238 A:A:L44 99.51257.31YesNo099
7A:A:I244 A:A:L44 99.44182.85NoNo089
8A:A:I244 A:A:L46 1002.85NoNo088
9A:A:G47 A:A:L46 99.92671.71NoNo098
10A:A:G47 A:A:K53 99.62981.74NoNo099
11A:A:K53 A:A:L45 99.40322.82NoNo098
12A:A:I245 A:A:L45 98.86132.85NoNo078
13A:A:I245 A:A:I288 79.20715.89NoYes979
14A:A:A243 A:A:I288 87.4493.25NoYes089
15A:A:A243 A:A:T242 87.3261.68NoNo088
16A:A:H41 A:A:T242 87.20274.11YesNo068
17A:A:H41 R:R:L130 84.88972.57YesNo069
18A:A:K293 A:A:N50 23.40052.8NoNo099
19A:A:K293 A:A:N292 24.65912.8NoYes099
20A:A:N292 A:A:T364 25.12532.92YesYes099
21A:A:F290 A:A:T364 26.21516.49YesYes999
22A:A:F290 A:A:I245 19.57512.51YesNo997
23A:A:D252 A:A:N50 22.87854.04YesNo2089
24B:B:G115 B:B:G116 21.87682.11YesNo099
25B:B:G116 B:B:M101 22.04645.24NoNo099
26B:B:M101 B:B:Y145 21.99045.99NoYes098
27A:A:Q227 B:B:Y145 12.72762.25YesYes198
28A:A:F238 A:A:W234 23.19112YesYes199
29A:A:Q227 B:B:N119 11.14063.96YesNo099
30A:A:W281 B:B:W332 26.30861.87YesYes159
31B:B:R314 B:B:W332 27.012210YesYes189
32A:A:D252 A:A:N264 22.13256.73YesNo089
33A:A:N264 A:A:Y311 21.877810.47NoYes096
34A:A:Y253 A:A:Y311 15.73787.94YesYes086
35A:A:L297 A:A:Y253 13.77263.52NoYes088
36A:A:L297 A:A:Q294 13.50622.66NoYes086
37A:A:W281 B:B:D290 25.99582.23YesNo156
38B:B:D290 B:B:R314 26.13717.15NoYes168
39A:A:I383 R:R:L130 84.71142.85NoNo089
40A:A:I383 R:R:P129 84.37353.39NoYes1489
41R:R:H128 R:R:P129 82.98381.53NoYes049
42R:R:H128 R:R:Y123 82.84836.53NoYes047
43R:R:Y120 R:R:Y123 80.48721.99NoYes067
44R:R:V124 R:R:Y120 80.34498.83NoNo076
45R:R:I135 R:R:V124 80.20223.07NoNo077
46R:R:I135 R:R:M136 79.91582.92NoYes079
47B:B:C271 B:B:D290 51.79424.67NoNo156
48B:B:C271 B:B:Y289 51.10852.69NoYes157
49B:B:I273 B:B:Y289 36.64156.04YesYes167
50B:B:G244 B:B:I273 33.82867.05NoYes156
51B:B:G244 B:B:T243 34.91561.82NoYes158
52B:B:F253 B:B:T243 24.46162.59YesYes168
53B:B:F222 B:B:F253 20.48832.14YesYes186
54B:B:D258 B:B:F222 18.61674.78YesYes178
55B:B:I18 G:G:L19 13.885.71YesNo079
56G:G:L15 G:G:L19 12.34072.77YesNo2329
57B:B:W297 B:B:Y289 11.84595.79YesYes187
58B:B:W297 B:B:Y264 11.30465.79YesYes085
59B:B:M262 B:B:Y264 11.60938.38NoYes045
60B:B:L30 B:B:M262 11.25625.65YesNo054
61B:B:M61 B:B:W63 10.15294.65YesYes367
62B:B:N313 B:B:W332 11.21236.78NoYes079
63B:B:D333 B:B:N313 10.91175.39YesNo097
64B:B:D333 B:B:H311 10.34626.3YesYes1199
65B:B:G115 B:B:T102 16.90611.82YesNo098
66B:B:C149 B:B:T102 16.68463.38NoNo088
67B:B:I157 B:B:T159 12.67463.04NoYes079
68B:B:F151 B:B:I157 10.01055.02YesNo097
69B:B:H142 B:B:S161 37.82039.76YesYes199
70B:B:G144 B:B:S161 10.68171.86NoYes089
71B:B:G162 B:B:Y145 29.16872.9NoYes198
72B:B:G162 B:B:S161 29.03493.71NoYes199
73B:B:G144 B:B:N119 10.84983.39NoNo089
74B:B:C121 B:B:C149 11.39551.82NoNo088
75B:B:C121 B:B:L139 11.16553.17NoNo089
76B:B:G174 B:B:L139 31.09761.71NoNo049
77B:B:G174 B:B:T173 30.44461.82NoNo045
78B:B:Q175 B:B:T173 27.82875.67NoNo045
79B:B:Q175 B:B:T177 27.17381.42NoNo044
80B:B:L168 B:B:T177 10.62044.42NoNo064
81B:B:T177 B:B:T178 15.92426.28NoNo044
82B:B:G216 B:B:T178 15.26421.82NoNo044
83B:B:F180 B:B:G216 11.96153.01YesNo074
84R:R:F62 R:R:M136 65.71392.49YesYes1379
85R:R:F62 R:R:V145 34.94122.62YesNo076
86R:R:V145 R:R:W149 34.75749.81NoNo065
87R:R:L110 R:R:W149 34.5843.42YesNo055
88R:R:L110 R:R:S152 34.62754.5YesNo056
89R:R:F113 R:R:S152 34.43252.64YesNo036
90R:R:F113 R:R:N109 31.93794.83YesYes233
91L:L:?1 R:R:N109 29.72626.1YesYes203
92L:L:?1 R:R:F104 11.53555.41YesYes205
93L:L:?1 R:R:L181 15.99882.05YesNo004
94R:R:F62 R:R:M118 28.60232.49YesNo079
95R:R:M118 R:R:Y289 28.43562.39NoYes099
96R:R:N285 R:R:Y289 24.84532.33YesYes699
97R:R:N285 R:R:T281 22.14324.39YesNo097
98R:R:F251 R:R:T281 21.26379.08NoNo067
99R:R:F251 R:R:I255 19.7747.54NoNo063
100R:R:I255 R:R:Y277 17.07546.04NoYes037
101R:R:T274 R:R:Y277 11.10084.99NoYes277
102R:R:L181 R:R:M101 15.16492.83NoNo045
103R:R:M101 R:R:M163 14.90715.78NoNo054
104B:B:C317 B:B:M61 10.86323.24NoYes076
105A:A:Q227 A:A:W234 22.67575.48YesYes199
106A:A:C237 B:B:M101 43.31524.86YesNo089
107B:B:H142 B:B:W169 24.59799.52YesYes198
108B:B:L139 B:B:W169 20.60347.97NoYes098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F104 5.41 2 Yes Yes 0 5 0 1
L:L:?1 R:R:G108 2.53 2 Yes No 0 4 0 1
L:L:?1 R:R:N109 6.1 2 Yes Yes 0 3 0 1
L:L:?1 R:R:H155 5.71 2 Yes Yes 0 3 0 1
L:L:?1 R:R:H159 3.8 2 Yes Yes 0 4 0 1
L:L:?1 R:R:L181 2.05 2 Yes No 0 4 0 1
L:L:?1 R:R:I199 4.22 2 Yes No 0 4 0 1
L:L:?1 R:R:G203 2.53 2 Yes No 0 5 0 1
L:L:?1 R:R:I207 10.56 2 Yes No 0 3 0 1
L:L:?1 R:R:Y259 13.88 2 Yes Yes 0 8 0 1
R:R:F104 R:R:F73 7.5 2 Yes No 5 5 1 2
R:R:F73 R:R:G108 4.52 0 No No 5 4 2 1
R:R:F104 R:R:T77 2.59 2 Yes No 5 6 1 2
R:R:F178 R:R:T77 2.59 2 Yes No 6 6 2 2
R:R:L181 R:R:M101 2.83 0 No No 4 5 1 2
R:R:F104 R:R:F178 10.72 2 Yes Yes 5 6 1 2
R:R:F104 R:R:Y259 2.06 2 Yes Yes 5 8 1 1
R:R:F104 R:R:T278 2.59 2 Yes No 5 6 1 2
R:R:H155 R:R:I105 2.65 2 Yes No 3 4 1 2
R:R:H159 R:R:I105 2.65 2 Yes No 4 4 1 2
R:R:N109 R:R:S112 2.98 2 Yes No 3 5 1 2
R:R:F113 R:R:N109 4.83 2 Yes Yes 3 3 2 1
R:R:H155 R:R:N109 8.93 2 Yes Yes 3 3 1 1
R:R:N109 R:R:V206 5.91 2 Yes No 3 3 1 2
R:R:F113 R:R:V206 2.62 2 Yes No 3 3 2 2
R:R:H155 R:R:H159 9.55 2 Yes Yes 3 4 1 1
R:R:E202 R:R:H155 19.69 0 Yes Yes 2 3 2 1
R:R:H159 R:R:I199 2.65 2 Yes No 4 4 1 1
R:R:D180 R:R:L181 2.71 2 Yes No 8 4 2 1
R:R:D180 R:R:Y259 10.34 2 Yes Yes 8 8 2 1
R:R:E202 R:R:G203 3.27 0 Yes No 2 5 2 1
R:R:E202 R:R:V206 7.13 0 Yes No 2 3 2 2
R:R:I207 R:R:I255 2.94 0 No No 3 3 1 2
R:R:I207 R:R:I256 2.94 0 No No 3 4 1 2
R:R:I255 R:R:Y277 6.04 0 No Yes 3 7 2 2
R:R:Y259 R:R:Y277 4.96 2 Yes Yes 8 7 1 2
R:R:T278 R:R:Y277 9.99 0 No Yes 6 7 2 2
R:R:F200 R:R:I199 1.26 0 No No 4 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription

PDB Summary
PDB 8UXY
Class O1
SubFamily Odorant receptors
Type Odorant family 51
SubType consOR1
Species Homo Sapiens
Ligand L-menthol
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.3
Date 2024-10-30 
D.O.I. doi.org/10.1038/s41586-024-08126-0
Net Summary
Imin 1.71
Number of Linked Nodes 840
Number of Links 1057
Number of Hubs 177
Number of Links mediated by Hubs 635
Number of Communities 30
Number of Nodes involved in Communities 273
Number of Links involved in Communities 390
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 918548
Length Of Smallest Path 3
Average Path Length 30.597
Length of Longest Path 63
Minimum Path Strength 1.21
Average Path Strength 4.21089
Maximum Path Strength 16.75
Minimum Path Correlation 0.7
Average Path Correlation 0.978151
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 45.4508
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.7436
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeXUQ
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeXUQ
NameLevomenthol
Synonyms(-)-Menthol
Identifier
FormulaC10 H20 O
Molecular Weight156.265
SMILES
PubChem16666
Formal Charge0
Total Atoms31
Total Chiral Atoms3
Total Bonds31
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8UXY_Chain_A
NEEKAQREA NKKIEKQLQ KDKQVYRAT HRLLLLGAS GKSTIVKQM 
RGIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND VTAIIFVVS 
SYNRLQEAL NLFKSIWNN RWLRTISVI LFLNKQDLL AEKVLAGKS 
KIEDYFPEF ARYTTPPGE DPRVTRAKY FIRDEFLRI STASGDGRH 
YCYPHFTCA VDTENRRFN DCRDIIQRM HLRQYELLD NDDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8UXY_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8UXY_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtCons
Sequence
>8UXY_Chain_R
SEFLLLGLS SQPEQQNLL FALFLSMYL VTVLGNLLI ILAISSDSH 
LHTPMYFFL SNLSFTDIC FSSVTVPKM LVNIQTQSK SISYAGCLT 
QMYFFIAFG NLDSFLLAV MAYDRYVAI CHPLHYTTI MSPRLCVLL 
VALSWVLSN LHALLHTLL MARLSFCAS NEIPHFFCD LSPLLKLSC 
SDTHVNELV IFTEGLLVI VTPFLCILV SYVRIVSTV LKIPSAKGK 
WKAFSTCGS HLTVVSLFY GTIIGVYFQ PLSTYSVKD TVATVMYTV 
VTPMLNPFI YSLRNKDMK GALRKL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UXYO1Odorant receptorsOdorant family 51consOR1Homo sapiensL-menthol-Gs/β1/γ23.32024-10-30doi.org/10.1038/s41586-024-08126-0
8UXY (No Gprot) O1Odorant receptorsOdorant family 51consOR1Homo sapiensL-menthol-3.32024-10-30doi.org/10.1038/s41586-024-08126-0




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