psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F104	5.41	Yes	Yes	1	0	5
2	L:L:?1	R:R:N109	6.1	Yes	Yes	1	0	3
3	L:L:?1	R:R:H155	5.71	Yes	Yes	1	0	3
4	L:L:?1	R:R:H159	3.8	Yes	No	1	0	4
5	L:L:?1	R:R:I199	4.22	Yes	No	0	0	4
6	L:L:?1	R:R:I207	10.56	Yes	No	0	0	3
7	L:L:?1	R:R:Y259	13.88	Yes	No	0	0	8
8	R:R:E11	R:R:S91	7.19	No	No	0	6	4
9	R:R:C97	R:R:F12	2.79	No	Yes	0	9	9
10	R:R:F12	R:R:F168	10.72	Yes	No	4	9	7
11	R:R:F12	R:R:I174	3.77	Yes	Yes	0	9	8
12	R:R:K90	R:R:L13	2.82	No	Yes	0	3	6
13	R:R:L13	R:R:N172	8.24	Yes	No	5	6	6
14	R:R:E173	R:R:L13	5.3	No	Yes	5	3	6
15	R:R:I174	R:R:L14	2.85	Yes	No	0	8	9
16	R:R:K90	R:R:L15	2.82	No	No	0	3	5
17	R:R:F177	R:R:L17	7.31	Yes	No	1	7	6
18	R:R:L17	R:R:V275	4.47	No	No	1	6	6
19	R:R:Q20	R:R:S18	2.89	Yes	No	6	2	7
20	R:R:Q23	R:R:S18	8.66	No	No	6	3	7
21	R:R:Q20	R:R:S19	4.33	Yes	No	0	2	4
22	R:R:Q20	R:R:Q23	11.52	Yes	No	6	2	3
23	R:R:E22	R:R:P21	4.72	No	No	0	4	5
24	R:R:I85	R:R:Q24	4.12	No	No	0	4	6
25	R:R:F31	R:R:L27	3.65	No	No	0	6	5
26	R:R:F28	R:R:L82	4.87	No	No	0	7	8
27	R:R:F28	R:R:Q86	11.71	No	No	0	7	5
28	R:R:L30	R:R:M34	4.24	No	No	0	4	5
29	R:R:F31	R:R:M81	8.71	No	No	0	6	5
30	R:R:F31	R:R:V279	6.55	No	No	0	6	5
31	R:R:L32	R:R:L82	2.77	No	No	0	6	8
32	R:R:M283	R:R:M34	4.33	No	No	0	5	5
33	R:R:V39	R:R:Y35	6.31	No	Yes	0	5	9
34	R:R:S74	R:R:Y35	3.82	No	Yes	0	7	9
35	R:R:S75	R:R:Y35	6.36	No	Yes	0	7	9
36	R:R:P79	R:R:Y35	4.17	No	Yes	0	9	9
37	R:R:N42	R:R:T38	4.39	Yes	No	0	9	7
38	R:R:M283	R:R:T38	3.01	No	No	0	5	7
39	R:R:N42	R:R:S67	5.96	Yes	No	0	9	8
40	R:R:D70	R:R:N42	2.69	Yes	Yes	0	9	9
41	R:R:I71	R:R:N42	8.5	No	Yes	0	5	9
42	R:R:N42	R:R:P286	6.52	Yes	No	0	9	9
43	R:R:I45	R:R:S67	4.64	No	No	0	8	8
44	R:R:I45	R:R:S290	10.84	No	No	0	8	8
45	R:R:I45	R:R:L291	7.14	No	No	0	8	8
46	R:R:I46	R:R:S67	3.1	No	No	0	7	8
47	R:R:I49	R:R:L55	4.28	Yes	No	7	7	9
48	R:R:I49	R:R:Y60	7.25	Yes	Yes	7	7	9
49	R:R:I49	R:R:S64	3.1	Yes	No	0	7	5
50	R:R:I49	R:R:M296	2.92	Yes	Yes	0	7	7
51	R:R:S50	R:R:S51	6.52	No	No	0	2	2
52	R:R:D52	R:R:S53	8.83	No	No	0	7	4
53	R:R:D52	R:R:L303	10.86	No	No	0	7	6
54	R:R:A299	R:R:S53	3.42	No	No	0	8	4
55	R:R:L55	R:R:Y60	11.72	No	Yes	7	9	9
56	R:R:P58	R:R:T57	3.5	No	No	0	9	7
57	R:R:P58	R:R:Y132	4.17	No	Yes	0	9	9
58	R:R:C141	R:R:P58	3.77	No	No	0	7	9
59	R:R:M59	R:R:Y60	3.59	No	Yes	0	9	9
60	R:R:N293	R:R:Y60	4.65	No	Yes	0	9	9
61	R:R:D295	R:R:Y60	4.6	No	Yes	0	7	9
62	R:R:F61	R:R:N65	9.67	No	No	0	6	7
63	R:R:C141	R:R:F61	2.79	No	No	0	7	6
64	R:R:F62	R:R:V117	6.55	No	No	0	7	5
65	R:R:C141	R:R:F62	4.19	No	No	0	7	7
66	R:R:L63	R:R:S290	6.01	No	No	0	8	8
67	R:R:L114	R:R:N65	2.75	Yes	No	0	7	7
68	R:R:D70	R:R:L66	2.71	Yes	Yes	2	9	9
69	R:R:D111	R:R:L66	5.43	Yes	Yes	2	8	9
70	R:R:L114	R:R:L66	5.54	Yes	Yes	2	7	9
71	R:R:L115	R:R:L66	2.77	No	Yes	0	8	9
72	R:R:C72	R:R:F68	4.19	No	No	0	3	3
73	R:R:L110	R:R:T69	5.9	Yes	No	2	5	5
74	R:R:D111	R:R:T69	2.89	Yes	No	2	8	5
75	R:R:L114	R:R:T69	2.95	Yes	No	2	7	5
76	R:R:D111	R:R:D70	7.98	Yes	Yes	2	8	9
77	R:R:D70	R:R:N285	8.08	Yes	No	2	9	9
78	R:R:C72	R:R:F107	9.78	No	Yes	0	3	4
79	R:R:F104	R:R:F73	7.5	Yes	No	0	5	5
80	R:R:F73	R:R:G108	4.52	No	No	0	5	4
81	R:R:T77	R:R:V78	3.17	No	No	0	6	5
82	R:R:P79	R:R:V78	3.53	No	No	0	9	5
83	R:R:L82	R:R:V78	2.98	No	No	0	8	5
84	R:R:K80	R:R:N84	13.99	No	No	0	6	6
85	R:R:I92	R:R:K80	2.91	No	No	0	9	6
86	R:R:F177	R:R:M81	7.46	Yes	No	0	7	5
87	R:R:T87	R:R:V83	3.17	No	No	0	4	2
88	R:R:C179	R:R:I92	3.27	No	No	0	9	9
89	R:R:L98	R:R:Y94	5.86	No	Yes	0	5	4
90	R:R:C179	R:R:C97	7.28	No	No	0	9	9
91	R:R:C97	R:R:L184	3.17	No	No	0	9	6
92	R:R:F178	R:R:Q100	4.68	Yes	No	0	6	9
93	R:R:C179	R:R:Q100	3.05	No	No	0	9	9
94	R:R:M101	R:R:M163	5.78	No	No	0	5	4
95	R:R:L181	R:R:M101	2.83	No	No	0	4	5
96	R:R:N153	R:R:Y102	4.65	No	Yes	0	2	5
97	R:R:A156	R:R:Y102	5.34	No	Yes	0	5	5
98	R:R:T160	R:R:Y102	8.74	No	Yes	0	5	5
99	R:R:F103	R:R:F107	6.43	No	Yes	9	5	4
100	R:R:F104	R:R:F178	10.72	Yes	Yes	1	5	6
101	R:R:A156	R:R:I105	3.25	No	No	0	5	4
102	R:R:N109	R:R:S112	2.98	Yes	No	1	3	5
103	R:R:F113	R:R:N109	4.83	No	Yes	0	3	3
104	R:R:H155	R:R:N109	8.93	Yes	Yes	1	3	3
105	R:R:N109	R:R:V206	5.91	Yes	No	0	3	3
106	R:R:L110	R:R:L114	4.15	Yes	Yes	2	5	7
107	R:R:L110	R:R:W149	3.42	Yes	No	0	5	5
108	R:R:L110	R:R:S152	4.5	Yes	No	0	5	6
109	R:R:D111	R:R:N285	2.69	Yes	No	2	8	9
110	R:R:P210	R:R:S112	3.56	Yes	No	1	6	5
111	R:R:S112	R:R:Y252	6.36	No	Yes	1	5	6
112	R:R:F113	R:R:P210	2.89	No	Yes	0	3	6
113	R:R:A119	R:R:S217	3.42	No	No	0	9	9
114	R:R:V124	R:R:Y120	8.83	No	No	0	7	6
115	R:R:D121	R:R:Y132	5.75	No	Yes	8	9	9
116	R:R:D121	R:R:M136	4.16	No	No	8	9	9
117	R:R:H244	R:R:R122	3.39	Yes	No	0	9	9
118	R:R:C127	R:R:Y123	6.72	No	Yes	0	8	7
119	R:R:H128	R:R:Y123	6.53	No	Yes	0	4	7
120	R:R:R220	R:R:Y123	3.09	No	Yes	0	2	7
121	R:R:I135	R:R:V124	3.07	No	No	0	7	7
122	R:R:A125	R:R:Y132	5.34	No	Yes	0	9	9
123	R:R:I126	R:R:I221	2.94	No	No	0	9	9
124	R:R:C127	R:R:T224	3.38	No	No	0	8	6
125	R:R:M136	R:R:Y132	5.99	No	Yes	8	9	9
126	R:R:I135	R:R:M136	2.92	No	No	0	7	9
127	R:R:P138	R:R:S137	3.56	No	No	0	3	7
128	R:R:L140	R:R:L144	4.15	No	No	0	3	7
129	R:R:L143	R:R:L147	2.77	No	No	0	3	3
130	R:R:V145	R:R:W149	9.81	No	No	0	6	5
131	R:R:H155	R:R:H159	9.55	Yes	No	1	3	4
132	R:R:E202	R:R:H155	19.69	Yes	Yes	0	2	3
133	R:R:L162	R:R:N195	4.12	No	Yes	0	3	5
134	R:R:L162	R:R:V198	4.47	No	No	0	3	4
135	R:R:L184	R:R:M163	2.83	No	No	0	6	4
136	R:R:L185	R:R:M163	2.83	Yes	No	0	6	4
137	R:R:L166	R:R:S188	7.51	No	No	3	6	7
138	R:R:L166	R:R:T192	4.42	No	Yes	3	6	6
139	R:R:L166	R:R:N195	4.12	No	Yes	3	6	5
140	R:R:C169	R:R:C189	7.28	No	No	0	9	9
141	R:R:E173	R:R:S171	4.31	No	No	0	3	5
142	R:R:L187	R:R:S171	3	No	No	0	8	5
143	R:R:E173	R:R:N172	9.2	No	No	5	3	6
144	R:R:I174	R:R:P175	3.39	Yes	No	0	8	4
145	R:R:I174	R:R:L184	2.85	Yes	No	0	8	6
146	R:R:I174	R:R:L187	2.85	Yes	No	0	8	8
147	R:R:F177	R:R:H176	7.92	Yes	Yes	1	7	8
148	R:R:F178	R:R:H176	6.79	Yes	Yes	1	6	8
149	R:R:H176	R:R:P183	4.58	Yes	No	0	8	6
150	R:R:H176	R:R:T271	12.32	Yes	No	0	8	6
151	R:R:H176	R:R:T274	6.85	Yes	No	0	8	7
152	R:R:F177	R:R:F178	12.86	Yes	Yes	1	7	6
153	R:R:F177	R:R:V275	5.24	Yes	No	1	7	6
154	R:R:D180	R:R:L181	2.71	No	No	0	8	4
155	R:R:D180	R:R:P183	4.83	No	No	0	8	6
156	R:R:D180	R:R:Y259	10.34	No	No	0	8	8
157	R:R:S182	R:R:Y266	7.63	No	No	0	4	2
158	R:R:P183	R:R:Y266	5.56	No	No	0	6	2
159	R:R:L185	R:R:T192	2.95	Yes	Yes	3	6	6
160	R:R:L185	R:R:N195	4.12	Yes	Yes	3	6	5
161	R:R:L185	R:R:L263	2.77	Yes	No	0	6	4
162	R:R:S188	R:R:T192	3.2	No	Yes	3	7	6
163	R:R:D191	R:R:H193	10.08	No	No	0	7	3
164	R:R:N195	R:R:T192	2.92	Yes	Yes	3	5	6
165	R:R:E196	R:R:T192	4.23	No	Yes	0	5	6
166	R:R:E196	R:R:H193	6.15	No	No	0	5	3
167	R:R:E196	R:R:L263	3.98	No	No	0	5	4
168	R:R:L197	R:R:T201	2.95	No	No	0	2	3
169	R:R:E202	R:R:G203	3.27	Yes	No	0	2	5
170	R:R:E202	R:R:V206	7.13	Yes	No	0	2	3
171	R:R:L204	R:R:V208	2.98	No	No	0	2	3
172	R:R:F260	R:R:L204	6.09	No	No	0	4	2
173	R:R:I207	R:R:I255	2.94	No	No	0	3	3
174	R:R:I207	R:R:I256	2.94	No	No	0	3	4
175	R:R:L212	R:R:V208	2.98	No	No	0	2	3
176	R:R:P210	R:R:T209	3.5	Yes	No	0	6	1
177	R:R:P210	R:R:Y252	2.78	Yes	Yes	1	6	6
178	R:R:F211	R:R:L215	8.53	No	No	0	4	3
179	R:R:F211	R:R:Y252	12.38	No	Yes	0	4	6
180	R:R:H244	R:R:Y218	9.8	Yes	Yes	0	9	9
181	R:R:C241	R:R:V222	3.42	No	No	0	9	5
182	R:R:I228	R:R:P229	3.39	No	No	0	6	4
183	R:R:F238	R:R:K234	3.72	No	No	0	7	6
184	R:R:H244	R:R:T240	6.85	Yes	No	0	9	9
185	R:R:R292	R:R:S243	5.27	No	No	0	9	9
186	R:R:H244	R:R:Y289	6.53	Yes	No	0	9	9
187	R:R:I288	R:R:V247	6.14	No	No	0	9	8
188	R:R:L250	R:R:M276	8.48	No	No	0	5	4
189	R:R:F251	R:R:Y252	3.09	No	Yes	0	6	6
190	R:R:F251	R:R:I255	7.54	No	No	0	6	3
191	R:R:F251	R:R:T281	9.08	No	No	0	6	7
192	R:R:M276	R:R:T254	4.52	No	No	0	4	7
193	R:R:T254	R:R:Y277	4.99	No	Yes	0	7	7
194	R:R:I255	R:R:Y277	6.04	No	Yes	0	3	7
195	R:R:D270	R:R:V258	4.38	Yes	No	0	5	6
196	R:R:Y259	R:R:Y277	4.96	No	Yes	0	8	7
197	R:R:P262	R:R:Q261	3.16	No	No	10	7	5
198	R:R:Q261	R:R:T265	5.67	No	No	10	5	3
199	R:R:D270	R:R:Q261	6.53	Yes	No	0	5	5
200	R:R:P262	R:R:T265	6.99	No	No	10	7	3
201	R:R:D270	R:R:Y266	11.49	Yes	No	0	5	2
202	R:R:T274	R:R:Y277	4.99	No	Yes	0	7	7
203	R:R:T278	R:R:Y277	9.99	No	Yes	0	6	7
204	R:R:T278	R:R:V279	3.17	No	No	0	6	5
205	R:R:L284	R:R:V280	2.98	No	No	0	6	5
206	R:R:P282	R:R:T281	3.5	No	No	0	9	7
207	R:R:N285	R:R:T281	4.39	No	No	0	9	7
208	R:R:F287	R:R:P286	2.89	No	No	0	5	9
209	R:R:F287	R:R:L291	6.09	No	No	0	5	8
210	R:R:I288	R:R:Y289	3.63	No	No	0	9	9
211	R:R:M296	R:R:S290	3.07	Yes	No	0	7	8
212	R:R:L300	R:R:M296	5.65	No	Yes	0	6	7
213	R:R:K297	R:R:R301	3.71	No	No	0	6	4
214	R:R:G298	R:R:R301	3	No	No	0	1	4
215	R:R:H155	R:R:I105	2.65	Yes	No	1	3	4
216	R:R:H159	R:R:I105	2.65	No	No	1	4	4
217	R:R:H131	R:R:I135	2.65	No	No	0	7	7
218	R:R:R139	R:R:S137	2.64	No	No	0	3	7
219	R:R:F103	R:R:V76	2.62	No	No	9	5	5
220	R:R:F107	R:R:V76	2.62	Yes	No	9	4	5
221	R:R:R220	R:R:V216	2.62	No	No	0	2	3
222	R:R:F104	R:R:T77	2.59	Yes	No	1	5	6
223	R:R:F178	R:R:T77	2.59	Yes	No	1	6	6
224	R:R:F103	R:R:T99	2.59	No	No	0	5	4
225	R:R:V248	R:R:Y252	2.52	No	Yes	0	8	6
226	R:R:F62	R:R:M118	2.49	No	No	0	7	9
227	R:R:F238	R:R:L226	2.44	No	No	0	7	6
228	R:R:I214	R:R:Y218	2.42	No	Yes	0	8	9
229	R:R:I214	R:R:Y252	2.42	No	Yes	0	8	6
230	R:R:L245	R:R:Y218	2.34	No	Yes	0	7	9
231	R:R:F107	R:R:F73	2.14	Yes	No	0	4	5
232	R:R:F200	R:R:F260	2.14	No	No	0	4	4
233	R:R:F12	R:R:Y94	2.06	Yes	Yes	4	9	4
234	R:R:F168	R:R:Y94	2.06	No	Yes	4	7	4
235	R:R:Y120	R:R:Y123	1.99	No	Yes	0	6	7
236	R:R:C241	R:R:G242	1.96	No	No	0	9	6
237	R:R:A116	R:R:P210	1.87	No	Yes	0	7	6
238	R:R:G96	R:R:T99	1.82	No	No	0	5	4
239	R:R:A170	R:R:C169	1.81	No	No	0	5	9
240	R:R:A106	R:R:A156	1.79	No	No	0	3	5
241	R:R:P262	R:R:S264	1.78	No	No	0	7	5
242	R:R:G233	R:R:K232	1.74	No	No	0	7	3
243	R:R:G16	R:R:L15	1.71	No	No	0	8	5
244	R:R:G41	R:R:L40	1.71	No	No	0	7	2
245	R:R:A237	R:R:V225	1.7	No	No	0	8	7
246	R:R:A273	R:R:V258	1.7	No	No	0	4	6
247	R:R:C213	R:R:T209	1.69	No	No	0	4	1
248	R:R:C127	R:R:I126	1.64	No	No	0	8	9
249	R:R:S148	R:R:V117	1.62	No	No	0	6	5
250	R:R:A119	R:R:I214	1.62	No	No	0	9	8
251	R:R:S223	R:R:V219	1.62	No	No	0	3	3
252	R:R:A48	R:R:M296	1.61	No	Yes	0	5	7
253	R:R:S89	R:R:T87	1.6	No	No	0	2	4
254	R:R:V194	R:R:V198	1.6	No	No	0	1	4
255	R:R:P21	R:R:Q20	1.58	No	Yes	0	5	2
256	R:R:A299	R:R:L55	1.58	No	No	0	8	9
257	R:R:T133	R:R:T134	1.57	No	No	0	4	6
258	R:R:I228	R:R:S230	1.55	No	No	0	6	9
259	R:R:I288	R:R:S243	1.55	No	No	0	9	9
260	R:R:I221	R:R:V225	1.54	No	No	0	9	7
261	R:R:H128	R:R:P129	1.53	No	No	0	4	9
262	R:R:K234	R:R:S230	1.53	No	No	0	6	9
263	R:R:M34	R:R:V280	1.52	No	No	0	5	5
264	R:R:M283	R:R:V37	1.52	No	No	0	5	3
265	R:R:K80	R:R:V83	1.52	No	No	0	6	2
266	R:R:L13	R:R:S91	1.5	Yes	No	0	6	4
267	R:R:L27	R:R:S18	1.5	No	No	0	5	7
268	R:R:L140	R:R:S137	1.5	No	No	0	3	7
269	R:R:L144	R:R:V117	1.49	No	No	0	7	5
270	R:R:L158	R:R:V198	1.49	No	No	0	4	4
271	R:R:L226	R:R:V222	1.49	No	No	0	6	5
272	R:R:D191	R:R:S190	1.47	No	No	0	7	5
273	R:R:D270	R:R:S267	1.47	Yes	No	0	5	6
274	R:R:I85	R:R:M81	1.46	No	No	0	4	5
275	R:R:G253	R:R:Y252	1.45	No	Yes	0	6	6
276	R:R:K186	R:R:L263	1.41	No	No	0	4	4
277	R:R:E202	R:R:T201	1.41	Yes	No	0	2	3
278	R:R:L43	R:R:L47	1.38	No	No	0	2	2
279	R:R:L300	R:R:L44	1.38	No	No	0	6	5
280	R:R:C241	R:R:Y218	1.34	No	Yes	0	9	9
281	R:R:H131	R:R:L130	1.29	No	No	0	7	9
282	R:R:Q86	R:R:Q88	1.28	No	No	0	5	2
283	R:R:S93	R:R:Y94	1.27	No	Yes	0	8	4
284	R:R:F200	R:R:I199	1.26	No	No	0	4	4
285	R:R:F260	R:R:I256	1.26	No	No	0	4	4
286	R:R:K297	R:R:R292	1.24	No	No	0	6	9
287	R:R:F113	R:R:L151	1.22	No	No	0	3	3
288	R:R:L157	R:R:Y102	1.17	No	Yes	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.09714	7	1	0
2	R:R:F12	4.835	4	4	9
3	R:R:L13	4.465	4	5	6
4	R:R:Q20	5.08	4	6	2
5	R:R:Y35	5.165	4	0	9
6	R:R:N42	5.612	5	0	9
7	R:R:I49	4.3875	4	7	7
8	R:R:Y60	6.362	5	7	9
9	R:R:L66	4.1125	4	2	9
10	R:R:D70	5.365	4	2	9
11	R:R:Y94	2.8125	4	4	4
12	R:R:Y102	4.975	4	0	5
13	R:R:F104	6.555	4	1	5
14	R:R:F107	5.2425	4	9	4
15	R:R:N109	5.75	5	1	3
16	R:R:L110	4.4925	4	2	5
17	R:R:D111	4.7475	4	2	8
18	R:R:L114	3.8475	4	2	7
19	R:R:Y123	4.5825	4	0	7
20	R:R:Y132	5.3125	4	8	9
21	R:R:H155	9.306	5	1	3
22	R:R:I174	3.142	5	0	8
23	R:R:H176	7.692	5	1	8
24	R:R:F177	8.158	5	1	7
25	R:R:F178	7.528	5	1	6
26	R:R:L185	3.1675	4	3	6
27	R:R:T192	3.544	5	3	6
28	R:R:N195	3.82	4	3	5
29	R:R:E202	7.875	4	0	2
30	R:R:P210	2.92	5	1	6
31	R:R:Y218	3.975	4	0	9
32	R:R:H244	6.6425	4	0	9
33	R:R:Y252	4.42857	7	1	6
34	R:R:D270	5.9675	4	0	5
35	R:R:Y277	6.194	5	0	7
36	R:R:M296	3.3125	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F104	34.3051	5.41	Yes	Yes	1	0	5
2	R:R:F104	R:R:F178	20.9197	10.72	Yes	Yes	1	5	6
3	R:R:F178	R:R:Q100	29.4768	4.68	Yes	No	0	6	9
4	R:R:C179	R:R:Q100	28.5129	3.05	No	No	0	9	9
5	R:R:C179	R:R:C97	20.6573	7.28	No	No	0	9	9
6	R:R:C97	R:R:F12	11.8556	2.79	No	Yes	0	9	9
7	R:R:I174	R:R:L187	16.5925	2.85	Yes	No	0	8	8
8	R:R:L187	R:R:S171	14.9595	3	No	No	0	8	5
9	R:R:E173	R:R:S171	13.3206	4.31	No	No	0	3	5
10	R:R:E173	R:R:L13	10.0074	5.3	No	Yes	5	3	6
11	R:R:I174	R:R:L184	16.7104	2.85	Yes	No	0	8	6
12	L:L:?1	R:R:Y259	13.6212	13.88	Yes	No	0	0	8
13	R:R:D180	R:R:Y259	39.5431	10.34	No	No	0	8	8
14	R:R:D180	R:R:L181	32.7074	2.71	No	No	0	8	4
15	R:R:L181	R:R:M101	31.9941	2.83	No	No	0	4	5
16	R:R:M101	R:R:M163	31.266	5.78	No	No	0	5	4
17	R:R:L184	R:R:M163	15.9528	2.83	No	No	0	6	4
18	R:R:Y259	R:R:Y277	29.8806	4.96	No	Yes	0	8	7
19	R:R:T77	R:R:V78	11.2277	3.17	No	No	0	6	5
20	L:L:?1	R:R:I207	29.6949	10.56	Yes	No	0	0	3
21	R:R:I207	R:R:I255	31.0066	2.94	No	No	0	3	3
22	R:R:F251	R:R:I255	84.1533	7.54	No	No	0	6	3
23	R:R:F251	R:R:T281	100	9.08	No	No	0	6	7
24	R:R:N285	R:R:T281	99.5519	4.39	No	No	0	9	7
25	R:R:D70	R:R:N285	47.3633	8.08	Yes	No	2	9	9
26	R:R:D70	R:R:N42	26.7001	2.69	Yes	Yes	0	9	9
27	R:R:N42	R:R:S67	17.524	5.96	Yes	No	0	9	8
28	R:R:I45	R:R:S67	15.9263	4.64	No	No	0	8	8
29	R:R:I45	R:R:S290	14.4967	10.84	No	No	0	8	8
30	R:R:M296	R:R:S290	12.9403	3.07	Yes	No	0	7	8
31	R:R:D70	R:R:L66	28.7045	2.71	Yes	Yes	2	9	9
32	R:R:L114	R:R:L66	50.7708	5.54	Yes	Yes	2	7	9
33	R:R:L114	R:R:N65	72.1857	2.75	Yes	No	0	7	7
34	R:R:F61	R:R:N65	70.1282	9.67	No	No	0	6	7
35	R:R:C141	R:R:F61	68.059	2.79	No	No	0	7	6
36	R:R:C141	R:R:P58	47.2867	3.77	No	No	0	7	9
37	R:R:D111	R:R:N285	51.9528	2.69	Yes	No	2	8	9
38	R:R:D111	R:R:L66	24.7399	5.43	Yes	Yes	2	8	9
39	R:R:D111	R:R:T69	27.2749	2.89	Yes	No	2	8	5
40	R:R:L114	R:R:T69	23.4871	2.95	Yes	No	2	7	5
41	R:R:P58	R:R:Y132	43.0184	4.17	No	Yes	0	9	9
42	R:R:C141	R:R:F62	20.0118	4.19	No	No	0	7	7
43	R:R:F62	R:R:V117	15.6021	6.55	No	No	0	7	5
44	L:L:?1	R:R:H155	11.0332	5.71	Yes	Yes	1	0	3
45	R:R:H155	R:R:I105	10.6028	2.65	Yes	No	1	3	4
46	R:R:A156	R:R:I105	14.6411	3.25	No	No	0	5	4
47	L:L:?1	R:R:N109	16.2771	6.1	Yes	Yes	1	0	3
48	R:R:N109	R:R:S112	22.871	2.98	Yes	No	1	3	5
49	R:R:S112	R:R:Y252	21.0995	6.36	No	Yes	1	5	6
50	R:R:I214	R:R:Y252	28.8489	2.42	No	Yes	0	8	6
51	R:R:M136	R:R:Y132	36.9934	5.99	No	Yes	8	9	9
52	R:R:I135	R:R:M136	34.8917	2.92	No	No	0	7	9
53	R:R:I135	R:R:V124	28.3832	3.07	No	No	0	7	7
54	R:R:V124	R:R:Y120	26.2019	8.83	No	No	0	7	6
55	R:R:I214	R:R:Y218	25.5711	2.42	No	Yes	0	8	9
56	R:R:H244	R:R:Y218	13.0346	9.8	Yes	Yes	0	9	9
57	R:R:Y120	R:R:Y123	24.0147	1.99	No	Yes	0	6	7
58	R:R:C127	R:R:Y123	12.9904	6.72	No	Yes	0	8	7
59	R:R:L144	R:R:V117	11.1894	1.49	No	No	0	7	5
60	R:R:L185	R:R:M163	22.8622	2.83	Yes	No	0	6	4
61	R:R:D180	R:R:P183	11.0597	4.83	No	No	0	8	6
62	R:R:T274	R:R:Y277	18.3405	4.99	No	Yes	0	7	7
63	R:R:P183	R:R:Y266	16.2388	5.56	No	No	0	6	2
64	R:R:C241	R:R:Y218	10.9506	1.34	No	Yes	0	9	9
65	R:R:D270	R:R:Y266	13.0376	11.49	Yes	No	0	5	2
66	R:R:F251	R:R:Y252	32.9433	3.09	No	Yes	0	6	6
67	R:R:I255	R:R:Y277	53.6949	6.04	No	Yes	0	3	7
68	R:R:H176	R:R:T274	17.8659	6.85	Yes	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F104	5.41	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N109	6.1	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H155	5.71	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H159	3.8	1	Yes	No	0	4	0	1
L:L:?1	R:R:I199	4.22	1	Yes	No	0	4	0	1
L:L:?1	R:R:I207	10.56	1	Yes	No	0	3	0	1
L:L:?1	R:R:Y259	13.88	1	Yes	No	0	8	0	1
R:R:F104	R:R:F73	7.5	1	Yes	No	5	5	1	2
R:R:F104	R:R:F178	10.72	1	Yes	Yes	5	6	1	2
R:R:N109	R:R:S112	2.98	1	Yes	No	3	5	1	2
R:R:F113	R:R:N109	4.83	0	No	Yes	3	3	2	1
R:R:H155	R:R:N109	8.93	1	Yes	Yes	3	3	1	1
R:R:N109	R:R:V206	5.91	1	Yes	No	3	3	1	2
R:R:H155	R:R:H159	9.55	1	Yes	No	3	4	1	1
R:R:E202	R:R:H155	19.69	0	Yes	Yes	2	3	2	1
R:R:D180	R:R:Y259	10.34	0	No	No	8	8	2	1
R:R:E202	R:R:V206	7.13	0	Yes	No	2	3	2	2
R:R:I207	R:R:I255	2.94	0	No	No	3	3	1	2
R:R:I207	R:R:I256	2.94	0	No	No	3	4	1	2
R:R:I255	R:R:Y277	6.04	0	No	Yes	3	7	2	2
R:R:Y259	R:R:Y277	4.96	0	No	Yes	8	7	1	2
R:R:H155	R:R:I105	2.65	1	Yes	No	3	4	1	2
R:R:H159	R:R:I105	2.65	1	No	No	4	4	1	2
R:R:F104	R:R:T77	2.59	1	Yes	No	5	6	1	2
R:R:F178	R:R:T77	2.59	1	Yes	No	6	6	2	2
R:R:F200	R:R:I199	1.26	0	No	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8UXY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.69
Number of Linked Nodes	264
Number of Links	288
Number of Hubs	36
Number of Links mediated by Hubs	137
Number of Communities	10
Number of Nodes involved in Communities	48
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	59917
Length Of Smallest Path	3
Average Path Length	16.022
Length of Longest Path	37
Minimum Path Strength	1.54
Average Path Strength	5.04437
Maximum Path Strength	14.62
Minimum Path Correlation	0.71
Average Path Correlation	0.922126
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	42.116
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.2725
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	XUQ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	XUQ
Name	Levomenthol
Synonyms	L-menthol
Identifier
Formula	C10 H20 O
Molecular Weight	156.265
SMILES
PubChem	16666
Formal Charge	0
Total Atoms	31
Total Chiral Atoms	3
Total Bonds	31
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	-
Sequence	>8UXY_nogp_Chain_R S E F L L L G L S S Q P E Q Q N L L F A L F L S M Y L V T V L G N L L I I L A I S S D S H L H T P M Y F F L S N L S F T D I C F S S V T V P K M L V N I Q T Q S K S I S Y A G C L T Q M Y F F I A F G N L D S F L L A V M A Y D R Y V A I C H P L H Y T T I M S P R L C V L L V A L S W V L S N L H A L L H T L L M A R L S F C A S N E I P H F F C D L S P L L K L S C S D T H V N E L V I F T E G L L V I V T P F L C I L V S Y V R I V S T V L K I P S A K G K W K A F S T C G S H L T V V S L F Y G T I I G V Y F Q P L S T Y S V K D T V A T V M Y T V V T P M L N P F I Y S L R N K D M K G A L R K L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UXY	O2	Odorant receptors	Odorant family 1	consOR1	Homo sapiens	L-menthol	-	Gs/β1/γ2	3.3	2024-10-30	doi.org/10.1038/s41586-024-08126-0
	8UXY (No Gprot)	O2	Odorant receptors	Odorant family 1	consOR1	Homo sapiens	L-menthol	-		3.3	2024-10-30	doi.org/10.1038/s41586-024-08126-0

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Download 8UXY_nogp.zip

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