Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 3.795426
2A:A:L44 5.7765119
3A:A:L45 4.5578
4A:A:S51 2.856579
5A:A:K53 5.38479
6A:A:F219 5.54728
7A:A:F222 8.584217
8A:A:Q227 4.4325129
9A:A:W234 4.2854129
10A:A:F246 4.294119
11A:A:D249 6.8375478
12A:A:L270 5.14406
13A:A:F273 3.9165239
14A:A:W277 7.344236
15A:A:Q294 3.468556
16A:A:L297 4.3325458
17A:A:Y339 3.895453
18A:A:F340 8.7325227
19A:A:R342 6.402554
20A:A:E344 6.494225
21A:A:S349 3.4654237
22A:A:Y360 5.405408
23A:A:F363 5.058555
24A:A:F376 4.234528
25A:A:I383 3.2775428
26A:A:L388 3.956508
27A:A:Y391 3.926504
28B:B:D27 2.93408
29B:B:L30 4.6775405
30B:B:T34 4.1425405
31B:B:H54 7.644509
32B:B:K57 9.51519
33B:B:Y59 8.44418
34B:B:W63 5.0025407
35B:B:R68 7.785405
36B:B:D76 5.4885209
37B:B:I80 6.162538
38B:B:W82 8.73667639
39B:B:N88 5.8275437
40B:B:K89 4.83667639
41B:B:I93 5.54407
42B:B:W99 6.338509
43B:B:Y105 3.3475406
44B:B:Y111 5.5425404
45B:B:L117 3.555129
46B:B:I123 3.3525406
47B:B:Y124 4.285266
48B:B:L139 5.575409
49B:B:H142 6.3325109
50B:B:Y145 5.885128
51B:B:F151 3.41409
52B:B:I157 3.31754107
53B:B:T159 4.954109
54B:B:W169 8.3285108
55B:B:Q176 5.91754104
56B:B:F180 5.6425157
57B:B:H183 7.9025409
58B:B:D186 5.105409
59B:B:F199 5.444159
60B:B:C204 5.52254167
61B:B:K209 9.094156
62B:B:W211 8.1445158
63B:B:Q220 7.205487
64B:B:F222 5.606588
65B:B:H225 7.12571769
66B:B:D228 8.21254169
67B:B:I229 4.17467
68B:B:I232 4.71408
69B:B:F235 7.3085176
70B:B:F241 6.1525486
71B:B:T243 5.29468
72B:B:D247 5.828569
73B:B:T249 6.1075466
74B:B:R251 12.1925468
75B:B:D254 4.6425409
76B:B:D258 6.286587
77B:B:Q259 3.3525406
78B:B:Y264 4.105605
79B:B:I273 4.3625406
80B:B:F278 3.864507
81B:B:R283 7.37599
82B:B:Y289 5.83717
83B:B:N295 7.605416
84B:B:L300 5.2925496
85B:B:K301 3.8825405
86B:B:H311 7.495409
87B:B:R314 8.576518
88B:B:W332 10.306519
89B:B:D333 7.0125409
90B:B:L336 4.3325437
91B:B:K337 5.82254246
92B:B:W339 7.1325249
93G:G:R27 5.845488
94G:G:Y40 7.344176
95G:G:D48 7.706599
96G:G:L51 5.952596
97G:G:P60 5.944259
98G:G:F61 4.6685258
99L:L:?1 4.19286740
100R:R:F11 6.22254149
101R:R:F27 3.222507
102R:R:I33 2.54405
103R:R:Y34 7.96254288
104R:R:N41 3.58667609
105R:R:L65 4.41254189
106R:R:M68 4.31254195
107R:R:D69 5.745189
108R:R:V77 4.67254286
109R:R:C96 3.7554149
110R:R:L100 4.0525405
111R:R:F101 5.8354295
112R:R:Y103 7.052544
113R:R:L104 3.6525405
114R:R:E110 6.07254188
115R:R:D120 4.88429
116R:R:P128 3.378529
117R:R:L129 4.182529
118R:R:Y131 5.32857729
119R:R:H158 5.1825405
120R:R:L165 3.3875407
121R:R:H175 10.545448
122R:R:F177 9.976545
123R:R:C178 4.5354149
124R:R:E179 9.375448
125R:R:T191 4.0325406
126R:R:N194 5.625405
127R:R:C202 2.964545
128R:R:Y217 4.422509
129R:R:H243 5.0665309
130R:R:Y251 3.976507
131R:R:Y258 4.83286747
132R:R:H265 6.975403
133R:R:Y277 4.9175445
134R:R:T278 3.675407
135R:R:I279 2.9925406
136R:R:N285 4.725189
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:N23 B:B:N88 18.38915.45NoYes377
2A:A:N23 B:B:K89 18.63596.99NoYes379
3B:B:I80 B:B:K89 19.85432.91YesYes389
4B:B:I80 B:B:K78 21.62952.91YesNo088
5B:B:D76 B:B:K78 22.63094.15YesNo098
6A:A:Y37 B:B:D76 24.93923.45NoYes2049
7A:A:R42 A:A:Y37 25.44776.17NoNo094
8A:A:F222 A:A:R42 26.68836.41YesNo079
9A:A:F222 B:B:W99 27.56513.03YesYes079
10B:B:Q75 B:B:W99 1004.38NoYes099
11B:B:K57 B:B:Q75 50.08329.49YesNo199
12B:B:K57 B:B:W332 49.991117.4YesYes199
13B:B:R314 B:B:W332 99.986115.99YesYes189
14B:B:R314 B:B:T274 83.21743.88YesNo188
15B:B:S275 B:B:T274 90.86953.2NoNo088
16B:B:L318 B:B:S275 90.78083NoNo068
17B:B:L318 B:B:T329 90.69682.95NoNo068
18B:B:H311 B:B:T329 89.72264.11YesNo098
19B:B:H311 B:B:S331 89.391412.55YesNo099
20B:B:D333 B:B:S331 89.32235.89YesNo099
21B:B:D312 B:B:D333 89.108810.65NoYes059
22B:B:D312 R:R:R302 89.0434.76NoNo056
23R:R:D51 R:R:R302 88.85815.96NoNo076
24R:R:D51 R:R:R53 88.73673.57NoNo075
25R:R:E295 R:R:R53 88.67955.82NoNo075
26R:R:E295 R:R:L54 88.62913.98NoNo079
27R:R:L54 R:R:Y59 88.592810.55NoNo099
28R:R:T56 R:R:Y59 88.51874.99NoNo079
29R:R:P57 R:R:T56 88.49755.25NoNo097
30R:R:P57 R:R:Y131 88.44232.78NoYes099
31R:R:D120 R:R:Y131 46.85515.75YesYes299
32B:B:Q75 B:B:Y59 49.995110.15NoYes198
33B:B:W332 B:B:Y59 49.99138.68YesYes198
34A:A:F238 B:B:W99 10.89566.01NoYes099
35A:A:F238 A:A:L44 10.706714.61NoYes099
36A:A:L44 A:A:L46 10.46114.15YesNo1198
37A:A:F246 A:A:L46 11.61113.65YesNo1198
38A:A:F246 A:A:L289 30.38653.65YesNo099
39A:A:L289 A:A:L291 19.38632.77NoNo098
40A:A:F363 A:A:L291 19.75514.87YesNo058
41A:A:F363 A:A:Q294 19.42063.51YesYes556
42A:A:Q294 A:A:S250 10.28052.89YesNo566
43A:A:I341 A:A:S250 10.29284.64NoNo586
44A:A:I308 A:A:I341 20.72832.94NoNo078
45A:A:I308 A:A:Y253 33.88467.25NoNo078
46A:A:K300 A:A:Y253 32.989213.14NoNo098
47A:A:K300 A:A:S251 32.63491.53NoNo099
48A:A:K293 A:A:S251 32.121.53NoNo099
49A:A:D249 A:A:K293 29.27295.53YesNo089
50A:A:D249 A:A:S51 28.61994.42YesYes789
51A:A:K53 A:A:S51 27.8613.06YesYes799
52A:A:K53 A:A:L45 27.26534.23YesYes798
53A:A:L45 A:A:M221 10.82115.65YesNo088
54A:A:L43 A:A:M221 10.84662.83NoNo078
55A:A:F219 A:A:L43 10.88833.65YesNo087
56A:A:L297 A:A:Q294 10.47983.99YesYes586
57A:A:I341 A:A:L297 10.51692.85NoYes588
58A:A:F345 A:A:L289 11.34784.87NoNo089
59A:A:F345 A:A:L270 11.17639.74NoYes086
60A:A:E344 A:A:L270 12.26842.65YesYes056
61A:A:E344 A:A:F340 12.101510.49YesYes2257
62A:A:F315 A:A:F340 13.35417.15NoYes067
63A:A:F315 A:A:I308 13.37937.54NoNo067
64A:A:I245 A:A:L45 16.85612.85NoYes078
65B:B:L117 B:B:W99 80.48754.56YesYes099
66B:B:L117 B:B:Y145 70.11553.52YesYes1298
67A:A:W234 B:B:Y145 17.81093.86YesYes1298
68B:B:D186 B:B:Y145 86.17369.2YesYes098
69A:A:R231 A:A:W234 18.12784NoYes099
70A:A:L272 A:A:R231 18.26983.64NoNo089
71A:A:F246 A:A:L272 18.44486.09YesNo1198
72B:B:C204 B:B:D186 66.60563.11YesYes079
73B:B:C204 B:B:D228 65.953110.89YesYes1679
74A:A:I245 A:A:I288 16.62245.89NoNo079
75A:A:D378 A:A:I288 16.164612.59NoNo079
76A:A:D378 A:A:Y360 16.67489.2NoYes078
77A:A:R385 R:R:M227 15.81087.44NoNo056
78A:A:L388 R:R:M227 15.46862.83YesNo086
79A:A:Y391 R:R:D120 44.97953.45YesYes049
80A:A:Y391 R:R:R121 88.45545.14YesNo049
81R:R:A124 R:R:Y131 44.70159.34NoYes099
82A:A:Y391 R:R:A124 44.54214YesNo049
83A:A:L388 A:A:L393 12.87894.15YesNo088
84R:R:R121 R:R:Y217 87.24163.09NoYes099
85R:R:H243 R:R:Y217 79.29366.53YesYes099
86R:R:H243 R:R:T239 12.15614.11YesNo099
87A:A:L393 R:R:T239 12.10942.95NoNo089
88R:R:H243 R:R:Y289 86.49976.53YesNo099
89R:R:N285 R:R:Y289 86.18175.81YesNo099
90R:R:N41 R:R:S66 12.16872.98YesNo098
91R:R:I44 R:R:S66 11.45463.1NoNo078
92B:B:D228 B:B:D246 65.60475.32YesNo099
93B:B:D246 B:B:S227 65.19141.47NoNo096
94B:B:D247 B:B:S227 64.98491.47YesNo096
95B:B:D247 B:B:H225 62.66715.04YesYes699
96B:B:H225 B:B:T243 61.16456.85YesYes698
97B:B:I232 B:B:T243 40.86993.04YesYes088
98B:B:F241 B:B:I232 19.98285.02YesYes068
99B:B:F222 B:B:F241 39.05027.5YesYes886
100B:B:F253 B:B:T243 20.19725.19NoYes068
101B:B:F241 B:B:F253 20.02469.65YesNo066
102B:B:D290 B:B:R314 16.34958.34NoYes168
103B:B:C271 B:B:D290 23.85823.11NoNo156
104B:B:C271 B:B:Y289 23.36634.03NoYes157
105B:B:W297 B:B:Y289 18.65136.75NoYes187
106B:B:W297 B:B:Y264 18.48153.86NoYes085
107B:B:D83 B:B:R68 15.27579.53NoYes085
108B:B:R68 B:B:Y85 13.704214.4YesNo054
109B:B:G116 B:B:M101 11.60353.49NoNo099
110B:B:G115 B:B:G116 11.3492.11NoNo099
111B:B:C114 B:B:G115 10.68421.96NoNo089
112B:B:C114 B:B:Y124 10.22565.38NoYes2686
113B:B:D186 B:B:G162 24.55683.35YesNo099
114B:B:G162 B:B:S161 24.0553.71NoNo099
115B:B:H142 B:B:S161 22.514516.74YesNo099
116B:B:H142 B:B:T159 10.49914.11YesYes1099
117B:B:I123 B:B:L139 11.83032.85YesYes069
118B:B:I123 B:B:Y111 12.62723.63YesYes064
119B:B:I232 B:B:V200 20.46796.14YesNo086
120B:B:L210 B:B:V200 19.09652.98NoNo056
121B:B:L210 B:B:Q220 17.49575.32NoYes057
122B:B:Q220 G:G:E22 51.61823.82YesNo079
123B:B:T221 G:G:E22 28.05417.06NoNo079
124B:B:K209 B:B:T221 25.22827.51YesNo067
125B:B:K209 B:B:W211 21.61959.28YesYes1568
126B:B:F199 B:B:W211 31.71549.02YesYes1598
127B:B:F199 B:B:V158 14.42452.62YesNo095
128B:B:L152 B:B:V158 12.9832.98NoNo035
129B:B:F222 B:B:Q220 34.779910.54YesYes887
130G:G:E22 G:G:Q18 22.86167.65NoNo099
131B:B:C218 G:G:Q18 22.15437.63NoNo059
132B:B:C218 B:B:W211 21.43685.22NoYes1558
133B:B:L152 B:B:Q156 10.10032.66NoNo035
134B:B:F199 B:B:V213 15.86692.62YesNo094
135B:B:R214 B:B:V213 14.42567.85NoNo094
136B:B:Q156 B:B:R214 10.10115.84NoNo059
137B:B:D153 B:B:Q156 17.314110.44NoNo055
138B:B:D153 B:B:N155 14.42894.04NoNo053
139B:B:D170 B:B:N155 11.54364.04NoNo093
140R:R:E110 R:R:N285 64.43893.94YesYes1889
141R:R:E110 R:R:F250 64.83884.66YesNo086
142L:L:?1 R:R:F250 64.22242.11YesNo006
143L:L:?1 R:R:Y103 19.45095.08YesYes404
144L:L:?1 R:R:L104 15.28783.6YesYes005
145L:L:?1 R:R:Y258 18.34827.12YesYes407
146R:R:Y103 R:R:Y277 12.08668.94YesYes445
147R:R:T278 R:R:Y277 22.83363.75YesYes075
148R:R:I279 R:R:T278 20.86583.04YesYes067
149R:R:Y258 R:R:Y277 12.16732.98YesYes475
150R:R:I279 R:R:V77 12.95864.61YesYes066
151R:R:H158 R:R:V197 12.90472.77YesNo053
152R:R:L161 R:R:V197 11.47442.98NoNo033
153R:R:L161 R:R:N194 10.75894.12NoYes035
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y103 5.08 4 Yes Yes 0 4 0 1
L:L:?1 R:R:L104 3.6 4 Yes Yes 0 5 0 1
L:L:?1 R:R:G107 5.94 4 Yes No 0 4 0 1
L:L:?1 R:R:C201 2.75 4 Yes No 0 3 0 1
L:L:?1 R:R:C202 2.75 4 Yes Yes 0 5 0 1
L:L:?1 R:R:Y258 7.12 4 Yes Yes 0 7 0 1
R:R:Y103 R:R:Y72 7.94 4 Yes No 4 5 1 2
R:R:L100 R:R:L104 4.15 0 Yes Yes 5 5 2 1
R:R:F177 R:R:Y103 10.32 4 Yes Yes 5 4 2 1
R:R:Y103 R:R:Y258 2.98 4 Yes Yes 4 7 1 1
R:R:Y103 R:R:Y277 8.94 4 Yes Yes 4 5 1 2
R:R:L104 R:R:S155 3 0 Yes No 5 6 1 2
R:R:H158 R:R:L104 3.86 0 Yes Yes 5 5 2 1
R:R:E110 R:R:F250 4.66 18 Yes No 8 6 2 1
R:R:H158 R:R:M198 5.25 0 Yes No 5 4 2 2
R:R:C201 R:R:H158 8.85 0 No Yes 3 5 1 2
R:R:P181 R:R:Y258 8.34 0 No Yes 4 7 2 1
R:R:C202 R:R:M198 4.86 4 Yes No 5 4 1 2
R:R:M198 R:R:Y258 4.79 4 No Yes 4 7 2 1
R:R:C202 R:R:Y258 4.03 4 Yes Yes 5 7 1 1
R:R:F250 R:R:T281 10.38 0 No No 6 8 1 2
R:R:M257 R:R:Y258 3.59 0 No Yes 5 7 2 1
R:R:Y258 R:R:Y277 2.98 4 Yes Yes 7 5 1 2
L:L:?1 R:R:F250 2.11 4 Yes No 0 6 0 1
R:R:G107 R:R:G108 2.11 0 No No 4 4 1 2
R:R:C202 R:R:L206 1.59 4 Yes No 5 3 1 2
R:R:C202 R:R:L259 1.59 4 Yes No 5 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription

PDB Summary
PDB 8UY0
Class O2
SubFamily Odorant receptors
Type Odorant family 2
SubType consOR2
Species Homo Sapiens
Ligand S-carvone
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.2
Date 2024-10-30 
D.O.I. doi.org/10.1038/s41586-024-08126-0
Net Summary
Imin 2.63
Number of Linked Nodes 841
Number of Links 956
Number of Hubs 136
Number of Links mediated by Hubs 503
Number of Communities 30
Number of Nodes involved in Communities 180
Number of Links involved in Communities 234
Path Summary
Number Of Nodes in MetaPath 154
Number Of Links MetaPath 153
Number of Shortest Paths 1553883
Length Of Smallest Path 3
Average Path Length 37.8502
Length of Longest Path 71
Minimum Path Strength 1.255
Average Path Strength 5.64903
Maximum Path Strength 16.695
Minimum Path Correlation 0.7
Average Path Correlation 0.984513
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 39.5554
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.55
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
Code0WU
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code0WU
Name(5S)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
SynonymsS-carvone
Identifier
FormulaC10 H14 O
Molecular Weight150.218
SMILES
PubChem16724
Formal Charge0
Total Atoms25
Total Chiral Atoms1
Total Bonds25
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8UY0_Chain_A
NEEKAQREA NKKIEKQLQ KDKQVYRAT HRLLLLGAS GKSTIVKQM 
RGIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND VTAIIFVVS 
SYNRLQEAL NLFKSIWNN RWLRTISVI LFLNKQDLL AEKVLASKI 
EDYFPEFAR YTTPPGEDP RVTRAKYFI RDEFLRIST ASRHYCYPH 
FTCAVDTEN RRFNDCRDI IQRMHLRQY ELLDNDDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8UY0_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8UY0_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtCons
Sequence
>8UY0_Chain_R
LLLAMSTDF ILLGLFDHP RELFVIIYL ALGNGIILI HLDSRLHTP 
MYFFLSQLS LMDLCYTST TVPKMLVNL LSGDKTISF AGCGAQLFL 
YLTGGTECL LLAMAYDRY VAICHPLRY PVMNPRVCL AAGSWLGSL 
DSIHTVLTL SLPFCGSRI NHFFCEVPL LKACADTSL NETVFVCCV 
LMLIPLSLV SYGILLAVL RMEGRRKAF STCSSHLTV VGFYGAAIY 
MYLQPKSYH SPEQDKVVS LFYTILTPM LNPLIYSLN KEVKGALRR 
VLGLLLLLL LLVLLLLLE LLILRLR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UY0O2Odorant receptorsOdorant family 2consOR2Homo sapiensS-carvone-Gs/β1/γ23.22024-10-30doi.org/10.1038/s41586-024-08126-0
8UY0 (No Gprot) O2Odorant receptorsOdorant family 2consOR2Homo sapiensS-carvone-3.22024-10-30doi.org/10.1038/s41586-024-08126-0




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