psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y103	5.08	Yes	Yes	1	0	4
2	L:L:?1	R:R:L104	3.6	Yes	Yes	1	0	5
3	L:L:?1	R:R:G107	5.94	Yes	No	0	0	4
4	L:L:?1	R:R:M198	2.45	Yes	Yes	1	0	4
5	L:L:?1	R:R:C201	2.75	Yes	No	0	0	3
6	L:L:?1	R:R:C202	2.75	Yes	Yes	1	0	5
7	L:L:?1	R:R:F250	2.11	Yes	No	0	0	6
8	L:L:?1	R:R:Y258	7.12	Yes	Yes	1	0	7
9	R:R:D10	R:R:S8	2.94	No	No	0	7	7
10	R:R:R171	R:R:T9	3.88	No	No	0	7	8
11	R:R:F11	R:R:F93	2.14	Yes	No	3	9	4
12	R:R:C96	R:R:F11	4.19	Yes	Yes	3	9	9
13	R:R:F11	R:R:F167	6.43	Yes	No	3	9	6
14	R:R:F11	R:R:R171	11.76	Yes	No	3	9	7
15	R:R:F11	R:R:I173	2.51	Yes	No	0	9	7
16	R:R:I91	R:R:L13	4.28	No	No	0	9	9
17	R:R:I173	R:R:L13	4.28	No	No	0	7	9
18	R:R:E172	R:R:L14	11.93	No	No	0	8	5
19	R:R:L14	R:R:N174	4.12	No	No	0	5	5
20	R:R:G15	R:R:M80	3.49	No	No	0	9	6
21	R:R:F17	R:R:L16	8.53	No	No	0	6	5
22	R:R:F17	R:R:L22	4.87	No	No	0	6	4
23	R:R:E23	R:R:P20	6.29	No	No	0	6	3
24	R:R:E23	R:R:L84	6.63	No	No	0	6	4
25	R:R:I30	R:R:L26	4.28	No	No	0	7	6
26	R:R:F27	R:R:V28	3.93	Yes	No	0	7	3
27	R:R:F27	R:R:L31	2.44	Yes	No	0	7	5
28	R:R:F27	R:R:L81	3.65	Yes	No	0	7	8
29	R:R:F27	R:R:L84	3.65	Yes	No	0	7	4
30	R:R:F27	R:R:L85	2.44	Yes	No	0	7	5
31	R:R:I33	R:R:L29	2.85	Yes	No	0	5	4
32	R:R:I30	R:R:L81	5.71	No	No	0	7	8
33	R:R:L31	R:R:L35	2.77	No	No	0	5	3
34	R:R:L32	R:R:L36	4.15	No	No	0	2	4
35	R:R:I33	R:R:M283	4.37	Yes	No	0	5	6
36	R:R:L38	R:R:Y34	16.41	No	Yes	0	5	8
37	R:R:S74	R:R:Y34	5.09	No	Yes	0	7	8
38	R:R:V77	R:R:Y34	7.57	Yes	Yes	6	6	8
39	R:R:P78	R:R:Y34	2.78	No	Yes	6	9	8
40	R:R:N41	R:R:S66	2.98	Yes	No	0	9	8
41	R:R:D69	R:R:N41	4.04	Yes	Yes	0	9	9
42	R:R:L70	R:R:N41	9.61	No	Yes	0	6	9
43	R:R:L300	R:R:L43	2.77	No	No	0	5	1
44	R:R:I44	R:R:S66	3.1	No	No	0	7	8
45	R:R:I44	R:R:S290	6.19	No	No	0	7	9
46	R:R:I44	R:R:V296	3.07	No	Yes	0	7	7
47	R:R:L46	R:R:L47	2.77	No	No	0	3	9
48	R:R:L46	R:R:L50	6.92	No	No	0	3	1
49	R:R:L300	R:R:L47	5.54	No	No	0	5	9
50	R:R:I48	R:R:Y59	2.42	No	Yes	0	7	9
51	R:R:I48	R:R:S63	3.1	No	No	0	7	4
52	R:R:L50	R:R:V303	2.98	No	No	0	1	4
53	R:R:D51	R:R:R53	3.57	No	Yes	2	7	5
54	R:R:A299	R:R:D51	4.63	No	No	0	8	7
55	R:R:D51	R:R:R302	5.96	No	No	2	7	6
56	R:R:H55	R:R:S52	6.97	No	No	0	8	4
57	R:R:L54	R:R:R53	2.43	No	Yes	2	9	5
58	R:R:E295	R:R:R53	5.82	No	Yes	2	7	5
59	R:R:R302	R:R:R53	2.13	No	Yes	2	6	5
60	R:R:L54	R:R:Y59	10.55	No	Yes	2	9	9
61	R:R:E295	R:R:L54	3.98	No	No	2	7	9
62	R:R:P57	R:R:T56	5.25	No	No	0	9	7
63	R:R:T56	R:R:Y59	4.99	No	Yes	0	7	9
64	R:R:P57	R:R:Y131	2.78	No	Yes	0	9	9
65	R:R:C140	R:R:P57	3.77	No	No	0	7	9
66	R:R:L62	R:R:Y59	2.34	No	Yes	0	9	9
67	R:R:N293	R:R:Y59	2.33	No	Yes	2	9	9
68	R:R:E295	R:R:Y59	2.24	No	Yes	2	7	9
69	R:R:V296	R:R:Y59	2.52	Yes	Yes	2	7	9
70	R:R:F60	R:R:F61	2.14	No	Yes	0	6	7
71	R:R:F60	R:R:Q64	2.34	No	No	0	6	7
72	R:R:C140	R:R:F60	2.79	No	No	0	7	6
73	R:R:F61	R:R:V116	5.24	Yes	No	0	7	7
74	R:R:F61	R:R:M117	4.98	Yes	No	0	7	9
75	R:R:D120	R:R:F61	4.78	No	Yes	0	9	7
76	R:R:L62	R:R:S290	6.01	No	No	0	9	9
77	R:R:M68	R:R:Q64	4.08	Yes	No	5	5	7
78	R:R:Q64	R:R:W148	5.48	No	No	5	7	6
79	R:R:D69	R:R:L65	2.71	Yes	Yes	4	9	9
80	R:R:E110	R:R:L65	5.3	Yes	Yes	4	8	9
81	R:R:L113	R:R:L65	4.15	No	Yes	0	6	9
82	R:R:L65	R:R:N285	5.49	Yes	Yes	4	9	9
83	R:R:C71	R:R:L67	3.17	No	No	0	3	4
84	R:R:M68	R:R:T109	4.52	Yes	No	5	5	5
85	R:R:L113	R:R:M68	2.83	No	Yes	0	6	5
86	R:R:M68	R:R:W148	5.82	Yes	No	5	5	6
87	R:R:D69	R:R:E110	10.39	Yes	Yes	4	9	8
88	R:R:D69	R:R:P282	4.83	Yes	No	0	9	8
89	R:R:D69	R:R:N285	6.73	Yes	Yes	4	9	9
90	R:R:C71	R:R:L106	3.17	No	No	0	3	6
91	R:R:Y103	R:R:Y72	7.94	Yes	No	0	4	5
92	R:R:L106	R:R:Y72	4.69	No	No	0	6	5
93	R:R:P282	R:R:T73	3.5	No	No	0	8	7
94	R:R:L102	R:R:T75	7.37	No	No	0	4	5
95	R:R:T278	R:R:T76	4.71	Yes	No	0	7	6
96	R:R:P78	R:R:V77	3.53	No	Yes	6	9	6
97	R:R:L81	R:R:V77	2.98	No	Yes	0	8	6
98	R:R:I279	R:R:V77	4.61	Yes	Yes	0	6	6
99	R:R:K79	R:R:N83	6.99	No	No	0	5	6
100	R:R:K79	R:R:Q99	2.71	No	No	0	5	9
101	R:R:F176	R:R:M80	7.46	No	No	0	7	6
102	R:R:D88	R:R:S86	8.83	No	No	0	4	5
103	R:R:F93	R:R:L163	6.09	No	No	0	4	4
104	R:R:F167	R:R:F93	2.14	No	No	3	6	4
105	R:R:C178	R:R:C96	7.28	Yes	Yes	3	9	9
106	R:R:F177	R:R:Q99	11.71	Yes	No	0	5	9
107	R:R:C178	R:R:Q99	6.1	Yes	No	0	9	9
108	R:R:L100	R:R:L104	4.15	Yes	Yes	0	5	5
109	R:R:L100	R:R:T159	4.42	Yes	No	0	5	5
110	R:R:C178	R:R:L100	3.17	Yes	Yes	0	9	5
111	R:R:L100	R:R:V180	4.47	Yes	No	0	5	5
112	R:R:F101	R:R:T105	7.78	Yes	No	1	5	2
113	R:R:F101	R:R:S155	7.93	Yes	No	1	5	6
114	R:R:F101	R:R:L156	2.44	Yes	No	0	5	4
115	R:R:F101	R:R:T159	5.19	Yes	No	0	5	5
116	R:R:L104	R:R:Y103	2.34	Yes	Yes	1	5	4
117	R:R:F177	R:R:Y103	10.32	Yes	Yes	1	5	4
118	R:R:Y103	R:R:Y258	2.98	Yes	Yes	1	4	7
119	R:R:Y103	R:R:Y277	8.94	Yes	Yes	1	4	5
120	R:R:L104	R:R:S155	3	Yes	No	1	5	6
121	R:R:H158	R:R:L104	3.86	Yes	Yes	0	5	5
122	R:R:S152	R:R:T105	3.2	No	No	0	2	2
123	R:R:S155	R:R:T105	6.4	No	No	1	6	2
124	R:R:G107	R:R:G108	2.11	No	No	0	4	4
125	R:R:T109	R:R:W148	8.49	No	No	5	5	6
126	R:R:E110	R:R:F250	4.66	Yes	No	0	8	6
127	R:R:E110	R:R:N285	3.94	Yes	Yes	4	8	9
128	R:R:L112	R:R:S147	4.5	No	No	0	4	6
129	R:R:L112	R:R:L150	4.15	No	No	0	4	3
130	R:R:L114	R:R:Y251	5.86	No	Yes	0	9	7
131	R:R:L143	R:R:V116	2.98	No	No	0	3	7
132	R:R:A118	R:R:I213	3.25	No	No	0	9	9
133	R:R:A118	R:R:S216	3.42	No	No	0	9	9
134	R:R:V123	R:R:Y119	7.57	No	No	0	7	5
135	R:R:M135	R:R:Y119	2.39	No	No	0	8	5
136	R:R:D120	R:R:Y131	5.75	No	Yes	7	9	9
137	R:R:D120	R:R:M135	5.54	No	No	7	9	8
138	R:R:R121	R:R:Y217	3.09	No	Yes	0	9	9
139	R:R:I220	R:R:R121	3.76	No	No	0	9	9
140	R:R:C126	R:R:Y122	6.72	No	No	0	8	7
141	R:R:S216	R:R:Y122	2.54	No	No	0	9	7
142	R:R:V123	R:R:Y131	2.52	No	Yes	0	7	9
143	R:R:L134	R:R:V123	2.98	No	No	0	1	7
144	R:R:A124	R:R:Y131	9.34	No	Yes	0	9	9
145	R:R:I125	R:R:I220	7.36	No	No	0	9	9
146	R:R:C126	R:R:R219	2.79	No	No	0	8	4
147	R:R:L134	R:R:R130	2.43	No	No	0	1	6
148	R:R:P132	R:R:Y131	4.17	No	Yes	0	4	9
149	R:R:M135	R:R:Y131	8.38	No	Yes	7	8	9
150	R:R:N136	R:R:R138	2.41	No	No	0	7	3
151	R:R:N136	R:R:V139	5.91	No	No	0	7	3
152	R:R:L143	R:R:V139	2.98	No	No	0	3	3
153	R:R:D154	R:R:G151	3.35	No	No	0	4	6
154	R:R:I157	R:R:L153	5.71	No	No	0	4	3
155	R:R:D154	R:R:M205	4.16	No	No	0	4	4
156	R:R:L156	R:R:V160	2.98	No	No	0	4	2
157	R:R:H158	R:R:V197	2.77	Yes	No	0	5	3
158	R:R:H158	R:R:M198	5.25	Yes	Yes	0	5	4
159	R:R:C201	R:R:H158	8.85	No	Yes	0	3	5
160	R:R:L163	R:R:T159	2.95	No	No	0	4	5
161	R:R:L161	R:R:N194	4.12	No	Yes	0	3	5
162	R:R:L161	R:R:V197	2.98	No	No	0	3	3
163	R:R:L165	R:R:S164	3	Yes	No	0	7	3
164	R:R:L165	R:R:P166	3.28	Yes	No	0	7	5
165	R:R:A189	R:R:L165	3.15	No	Yes	0	6	7
166	R:R:L165	R:R:N194	4.12	Yes	Yes	0	7	5
167	R:R:C188	R:R:P166	5.65	No	No	0	9	5
168	R:R:F167	R:R:R171	4.28	No	No	3	6	7
169	R:R:C168	R:R:C188	7.28	No	No	0	8	9
170	R:R:E172	R:R:S170	2.87	No	No	0	8	5
171	R:R:N174	R:R:P267	3.26	No	No	0	5	3
172	R:R:K271	R:R:N174	6.99	No	No	0	6	5
173	R:R:F176	R:R:H175	10.18	No	Yes	1	7	8
174	R:R:F177	R:R:H175	5.66	Yes	Yes	1	5	8
175	R:R:E179	R:R:H175	22.16	Yes	Yes	1	8	8
176	R:R:H175	R:R:S274	4.18	Yes	No	1	8	7
177	R:R:F176	R:R:F177	12.86	No	Yes	1	7	5
178	R:R:E179	R:R:F177	9.33	Yes	Yes	1	8	5
179	R:R:E179	R:R:P181	3.14	Yes	No	0	8	4
180	R:R:E179	R:R:S274	2.87	Yes	No	1	8	7
181	R:R:P181	R:R:V180	5.3	No	No	0	4	5
182	R:R:P181	R:R:Y258	8.34	No	Yes	0	4	7
183	R:R:L184	R:R:N194	5.49	No	Yes	0	5	5
184	R:R:K185	R:R:L186	2.82	No	No	0	4	2
185	R:R:D190	R:R:S192	10.31	No	No	0	7	2
186	R:R:N194	R:R:T191	8.77	Yes	Yes	0	5	6
187	R:R:E195	R:R:T191	4.23	No	Yes	0	4	6
188	R:R:L193	R:R:V197	2.98	No	No	0	2	3
189	R:R:C202	R:R:M198	4.86	Yes	Yes	1	5	4
190	R:R:M198	R:R:Y258	4.79	Yes	Yes	1	4	7
191	R:R:F199	R:R:L259	2.44	No	No	0	3	4
192	R:R:C202	R:R:Y258	4.03	Yes	Yes	1	5	7
193	R:R:L207	R:R:V203	4.47	No	No	0	3	3
194	R:R:I208	R:R:P209	3.39	No	No	0	2	6
195	R:R:I208	R:R:L212	4.28	No	No	0	2	4
196	R:R:P209	R:R:Y251	5.56	No	Yes	0	6	7
197	R:R:L210	R:R:Y251	3.52	No	Yes	0	4	7
198	R:R:I213	R:R:Y217	2.42	No	Yes	0	9	9
199	R:R:I213	R:R:Y251	2.42	No	Yes	0	9	7
200	R:R:C240	R:R:Y217	5.38	No	Yes	0	9	9
201	R:R:H243	R:R:Y217	6.53	Yes	Yes	0	9	9
202	R:R:L244	R:R:Y217	4.69	No	Yes	0	7	9
203	R:R:F237	R:R:L221	2.44	No	No	0	6	5
204	R:R:C240	R:R:L221	4.76	No	No	0	9	5
205	R:R:K235	R:R:T239	7.51	No	No	0	9	9
206	R:R:H243	R:R:T239	4.11	Yes	No	0	9	9
207	R:R:H243	R:R:S242	4.18	Yes	No	8	9	9
208	R:R:I288	R:R:S242	3.1	No	No	8	9	9
209	R:R:R292	R:R:S242	5.27	No	No	0	6	9
210	R:R:H243	R:R:I288	3.98	Yes	No	8	9	9
211	R:R:H243	R:R:Y289	6.53	Yes	No	0	9	9
212	R:R:L284	R:R:V246	2.98	No	No	0	6	8
213	R:R:G248	R:R:V247	3.68	No	No	0	4	8
214	R:R:V247	R:R:Y251	2.52	No	Yes	0	8	7
215	R:R:F250	R:R:T281	10.38	No	No	0	6	8
216	R:R:A253	R:R:Y277	4	No	Yes	0	7	5
217	R:R:I255	R:R:L259	2.85	No	No	0	4	4
218	R:R:H265	R:R:Y256	10.89	Yes	No	0	3	4
219	R:R:V273	R:R:Y256	6.31	No	No	0	5	4
220	R:R:M257	R:R:Y258	3.59	No	Yes	0	5	7
221	R:R:D270	R:R:M257	2.77	No	No	0	6	5
222	R:R:M257	R:R:V273	3.04	No	No	0	5	5
223	R:R:Y258	R:R:Y277	2.98	Yes	Yes	1	7	5
224	R:R:D270	R:R:Q260	6.53	No	No	0	6	4
225	R:R:P261	R:R:Y264	2.78	No	No	0	7	3
226	R:R:H265	R:R:Y264	3.27	Yes	No	0	3	3
227	R:R:H265	R:R:Q269	6.18	Yes	No	0	3	3
228	R:R:D270	R:R:H265	7.56	No	Yes	0	6	3
229	R:R:P267	R:R:S266	5.34	No	No	0	3	5
230	R:R:E268	R:R:S266	7.19	No	No	0	3	5
231	R:R:S274	R:R:T278	3.2	No	Yes	0	7	7
232	R:R:I279	R:R:L275	2.85	Yes	No	0	6	6
233	R:R:T278	R:R:Y277	3.75	Yes	Yes	0	7	5
234	R:R:I279	R:R:T278	3.04	Yes	Yes	0	6	7
235	R:R:P282	R:R:T281	5.25	No	No	0	8	8
236	R:R:N285	R:R:Y289	5.81	Yes	No	0	9	9
237	R:R:N293	R:R:V296	2.96	No	Yes	2	9	7
238	R:R:L300	R:R:L304	2.77	No	No	0	5	4
239	R:R:C96	R:R:G97	1.96	Yes	No	0	9	4
240	R:R:C111	R:R:G108	1.96	No	No	0	5	4
241	R:R:C168	R:R:G169	1.96	No	No	0	8	4
242	R:R:A145	R:R:G146	1.95	No	No	0	3	3
243	R:R:A115	R:R:P209	1.87	No	No	0	6	6
244	R:R:G87	R:R:S86	1.86	No	No	0	4	5
245	R:R:G95	R:R:S92	1.86	No	No	0	5	8
246	R:R:G151	R:R:T109	1.82	No	No	0	6	5
247	R:R:P132	R:R:V133	1.77	No	No	0	4	4
248	R:R:G42	R:R:I45	1.76	No	No	0	3	6
249	R:R:G252	R:R:I255	1.76	No	No	0	6	4
250	R:R:G298	R:R:K297	1.74	No	No	0	1	7
251	R:R:G40	R:R:L39	1.71	No	No	0	8	3
252	R:R:A94	R:R:S92	1.71	No	No	0	1	8
253	R:R:G146	R:R:L149	1.71	No	No	0	3	3
254	R:R:G151	R:R:L150	1.71	No	No	0	6	3
255	R:R:G305	R:R:L304	1.71	No	No	0	9	4
256	R:R:G42	R:R:N41	1.7	No	Yes	0	3	9
257	R:R:A236	R:R:V224	1.7	No	No	0	9	8
258	R:R:A187	R:R:T191	1.68	No	Yes	0	7	6
259	R:R:K262	R:R:P261	1.67	No	No	0	4	7
260	R:R:L291	R:R:P286	1.64	No	No	0	8	9
261	R:R:N41	R:R:P286	1.63	Yes	No	0	9	9
262	R:R:N136	R:R:P137	1.63	No	No	0	7	2
263	R:R:N285	R:R:P286	1.63	Yes	No	0	9	9
264	R:R:A182	R:R:I173	1.62	No	No	0	6	7
265	R:R:C96	R:R:L183	1.59	Yes	No	3	9	6
266	R:R:C111	R:R:L206	1.59	No	No	0	5	3
267	R:R:C178	R:R:L183	1.59	Yes	No	3	9	6
268	R:R:C202	R:R:L206	1.59	Yes	No	0	5	3
269	R:R:C202	R:R:L259	1.59	Yes	No	0	5	4
270	R:R:A254	R:R:L206	1.58	No	No	0	4	3
271	R:R:A37	R:R:N41	1.56	No	Yes	0	7	9
272	R:R:I220	R:R:V224	1.54	No	No	0	9	8
273	R:R:I288	R:R:V246	1.54	No	No	0	9	8
274	R:R:H19	R:R:P20	1.53	No	No	0	1	3
275	R:R:H127	R:R:P128	1.53	No	No	0	4	9
276	R:R:I12	R:R:T90	1.52	No	No	0	5	4
277	R:R:M58	R:R:T56	1.51	No	No	0	9	7
278	R:R:G298	R:R:R302	1.5	No	No	0	1	6
279	R:R:L47	R:R:V296	1.49	No	Yes	0	9	7
280	R:R:L204	R:R:V200	1.49	No	No	0	2	3
281	R:R:I30	R:R:I33	1.47	No	Yes	0	7	5
282	R:R:I279	R:R:I33	1.47	Yes	Yes	0	6	5
283	R:R:L106	R:R:T75	1.47	No	No	0	6	5
284	R:R:C126	R:R:H127	1.47	No	No	0	8	4
285	R:R:L184	R:R:T162	1.47	No	No	0	5	4
286	R:R:I12	R:R:K89	1.45	No	No	0	5	5
287	R:R:D190	R:R:T191	1.45	No	Yes	0	7	6
288	R:R:Q260	R:R:S263	1.44	No	No	0	4	6
289	R:R:Q269	R:R:V272	1.43	No	No	0	3	5
290	R:R:L16	R:R:L26	1.38	No	No	0	5	6
291	R:R:L16	R:R:L275	1.38	No	No	0	5	6
292	R:R:L214	R:R:L244	1.38	No	No	0	5	7
293	R:R:A223	R:R:R219	1.38	No	No	0	6	4
294	R:R:E23	R:R:K89	1.35	No	No	0	6	5
295	R:R:D88	R:R:N83	1.35	No	No	0	4	6
296	R:R:H49	R:R:L50	1.29	No	No	0	1	1
297	R:R:F276	R:R:L249	1.22	No	No	0	5	4
298	R:R:L222	R:R:R219	1.21	No	No	0	4	4
299	R:R:L225	R:R:R233	1.21	No	No	0	5	7
300	R:R:E231	R:R:R234	1.16	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	3.975	8	1	0
2	R:R:F11	5.406	5	3	9
3	R:R:F27	3.222	5	0	7
4	R:R:I33	2.54	4	0	5
5	R:R:Y34	7.9625	4	6	8
6	R:R:N41	3.58667	6	0	9
7	R:R:R53	3.4875	4	2	5
8	R:R:Y59	3.91286	7	2	9
9	R:R:F61	4.285	4	0	7
10	R:R:L65	4.4125	4	4	9
11	R:R:M68	4.3125	4	5	5
12	R:R:D69	5.74	5	4	9
13	R:R:V77	4.6725	4	6	6
14	R:R:C96	3.755	4	3	9
15	R:R:L100	4.0525	4	0	5
16	R:R:F101	5.835	4	1	5
17	R:R:Y103	6.26667	6	1	4
18	R:R:L104	3.39	5	1	5
19	R:R:E110	6.0725	4	4	8
20	R:R:Y131	5.49	6	7	9
21	R:R:H158	5.1825	4	0	5
22	R:R:L165	3.3875	4	0	7
23	R:R:H175	10.545	4	1	8
24	R:R:F177	9.976	5	1	5
25	R:R:C178	4.535	4	3	9
26	R:R:E179	9.375	4	1	8
27	R:R:T191	4.0325	4	0	6
28	R:R:N194	5.625	4	0	5
29	R:R:M198	4.3375	4	1	4
30	R:R:C202	2.964	5	1	5
31	R:R:Y217	4.422	5	0	9
32	R:R:H243	5.066	5	8	9
33	R:R:Y251	3.976	5	0	7
34	R:R:Y258	4.83286	7	1	7
35	R:R:H265	6.975	4	0	3
36	R:R:Y277	4.9175	4	1	5
37	R:R:T278	3.675	4	0	7
38	R:R:I279	2.9925	4	0	6
39	R:R:N285	4.72	5	4	9
40	R:R:V296	2.51	4	2	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L104	24.4503	3.6	Yes	Yes	1	0	5
2	R:R:L100	R:R:L104	16.216	4.15	Yes	Yes	0	5	5
3	R:R:C178	R:R:L100	12.312	3.17	Yes	Yes	0	9	5
4	R:R:C178	R:R:C96	14.8581	7.28	Yes	Yes	3	9	9
5	R:R:C96	R:R:F11	11.937	4.19	Yes	Yes	3	9	9
6	L:L:?1	R:R:Y103	28.7609	5.08	Yes	Yes	1	0	4
7	R:R:F177	R:R:Y103	13.6502	10.32	Yes	Yes	1	5	4
8	R:R:Y103	R:R:Y277	26.3451	8.94	Yes	Yes	1	4	5
9	R:R:T278	R:R:Y277	46.6664	3.75	Yes	Yes	0	7	5
10	R:R:I279	R:R:T278	47.7204	3.04	Yes	Yes	0	6	7
11	L:L:?1	R:R:Y258	27.1543	7.12	Yes	Yes	1	0	7
12	R:R:Y258	R:R:Y277	23.0411	2.98	Yes	Yes	1	7	5
13	R:R:I279	R:R:V77	29.9925	4.61	Yes	Yes	0	6	6
14	R:R:L81	R:R:V77	21.7542	2.98	No	Yes	0	8	6
15	R:R:F27	R:R:L81	20.6608	3.65	Yes	No	0	7	8
16	R:R:F27	R:R:L84	12.1146	3.65	Yes	No	0	7	4
17	R:R:E23	R:R:L84	10.3817	6.63	No	No	0	6	4
18	L:L:?1	R:R:F250	100	2.11	Yes	No	0	0	6
19	R:R:E110	R:R:F250	97.6236	4.66	Yes	No	0	8	6
20	R:R:D69	R:R:E110	31.8202	10.39	Yes	Yes	4	9	8
21	R:R:D69	R:R:N41	39.04	4.04	Yes	Yes	0	9	9
22	R:R:N41	R:R:S66	40.2321	2.98	Yes	No	0	9	8
23	R:R:I44	R:R:S66	39.1939	3.1	No	No	0	7	8
24	R:R:I44	R:R:V296	35.9057	3.07	No	Yes	0	7	7
25	R:R:L47	R:R:V296	13.3344	1.49	No	Yes	0	9	7
26	R:R:V296	R:R:Y59	25.2398	2.52	Yes	Yes	2	7	9
27	R:R:E110	R:R:L65	31.8912	5.3	Yes	Yes	4	8	9
28	R:R:L113	R:R:L65	39.1268	4.15	No	Yes	0	6	9
29	R:R:L113	R:R:M68	38.211	2.83	No	Yes	0	6	5
30	R:R:M68	R:R:Q64	30.5175	4.08	Yes	No	5	5	7
31	R:R:F60	R:R:Q64	31.5044	2.34	No	No	0	6	7
32	R:R:C140	R:R:F60	12.7028	2.79	No	No	0	7	6
33	R:R:C140	R:R:P57	11.8502	3.77	No	No	0	7	9
34	R:R:F60	R:R:F61	20.0529	2.14	No	Yes	0	6	7
35	R:R:D120	R:R:F61	11.6725	4.78	No	Yes	0	9	7
36	R:R:P57	R:R:Y131	10.1922	2.78	No	Yes	0	9	9
37	R:R:E110	R:R:N285	33.5886	3.94	Yes	Yes	4	8	9
38	R:R:F177	R:R:Q99	12.687	11.71	Yes	No	0	5	9
39	R:R:H158	R:R:L104	16.2713	3.86	Yes	Yes	0	5	5
40	L:L:?1	R:R:M198	10.3383	2.45	Yes	Yes	1	0	4
41	R:R:H158	R:R:M198	14.2699	5.25	Yes	Yes	0	5	4
42	L:L:?1	R:R:C201	10.8159	2.75	Yes	No	0	0	3
43	R:R:N285	R:R:Y289	50.1401	5.81	Yes	No	0	9	9
44	R:R:H243	R:R:Y289	48.9599	6.53	Yes	No	0	9	9
45	R:R:H243	R:R:Y217	39.6676	6.53	Yes	Yes	0	9	9
46	R:R:I213	R:R:Y217	26.2109	2.42	No	Yes	0	9	9
47	R:R:I213	R:R:Y251	12.7502	2.42	No	Yes	0	9	7
48	R:R:A118	R:R:I213	12.7857	3.25	No	No	0	9	9
49	R:R:A118	R:R:S216	11.3962	3.42	No	No	0	9	9
50	R:R:H158	R:R:V197	38.1518	2.77	Yes	No	0	5	3
51	R:R:L161	R:R:V197	34.0386	2.98	No	No	0	3	3
52	R:R:L161	R:R:N194	31.9702	4.12	No	Yes	0	3	5
53	R:R:L165	R:R:N194	15.1384	4.12	Yes	Yes	0	7	5
54	R:R:N194	R:R:T191	10.8515	8.77	Yes	Yes	0	5	6
55	R:R:M257	R:R:Y258	13.7568	3.59	No	Yes	0	5	7
56	R:R:D270	R:R:M257	10.3186	2.77	No	No	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y103	5.08	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L104	3.6	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:G107	5.94	1	Yes	No	0	4	0	1
L:L:?1	R:R:M198	2.45	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:C201	2.75	1	Yes	No	0	3	0	1
L:L:?1	R:R:C202	2.75	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F250	2.11	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y258	7.12	1	Yes	Yes	0	7	0	1
R:R:Y103	R:R:Y72	7.94	1	Yes	No	4	5	1	2
R:R:L100	R:R:L104	4.15	0	Yes	Yes	5	5	2	1
R:R:L104	R:R:Y103	2.34	1	Yes	Yes	5	4	1	1
R:R:F177	R:R:Y103	10.32	1	Yes	Yes	5	4	2	1
R:R:Y103	R:R:Y258	2.98	1	Yes	Yes	4	7	1	1
R:R:Y103	R:R:Y277	8.94	1	Yes	Yes	4	5	1	2
R:R:L104	R:R:S155	3	1	Yes	No	5	6	1	2
R:R:H158	R:R:L104	3.86	0	Yes	Yes	5	5	2	1
R:R:G107	R:R:G108	2.11	0	No	No	4	4	1	2
R:R:E110	R:R:F250	4.66	4	Yes	No	8	6	2	1
R:R:H158	R:R:M198	5.25	0	Yes	Yes	5	4	2	1
R:R:C201	R:R:H158	8.85	0	No	Yes	3	5	1	2
R:R:P181	R:R:Y258	8.34	0	No	Yes	4	7	2	1
R:R:C202	R:R:M198	4.86	1	Yes	Yes	5	4	1	1
R:R:M198	R:R:Y258	4.79	1	Yes	Yes	4	7	1	1
R:R:C202	R:R:Y258	4.03	1	Yes	Yes	5	7	1	1
R:R:F250	R:R:T281	10.38	0	No	No	6	8	1	2
R:R:M257	R:R:Y258	3.59	0	No	Yes	5	7	2	1
R:R:Y258	R:R:Y277	2.98	1	Yes	Yes	7	5	1	2
R:R:C202	R:R:L206	1.59	1	Yes	No	5	3	1	2
R:R:C202	R:R:L259	1.59	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8UY0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.11
Number of Linked Nodes	272
Number of Links	300
Number of Hubs	40
Number of Links mediated by Hubs	148
Number of Communities	8
Number of Nodes involved in Communities	47
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	46263
Length Of Smallest Path	3
Average Path Length	13.0349
Length of Longest Path	26
Minimum Path Strength	1.295
Average Path Strength	4.26952
Maximum Path Strength	16.17
Minimum Path Correlation	0.7
Average Path Correlation	0.921034
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	46.734
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.7862
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	0WU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	0WU
Name	(5S)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
Synonyms	S-carvone
Identifier
Formula	C10 H14 O
Molecular Weight	150.218
SMILES
PubChem	16724
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	25
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	-
Sequence	>8UY0_nogp_Chain_R L L L A M S T D F I L L G L F D H P R E L F V I I Y L A L G N G I I L I H L D S R L H T P M Y F F L S Q L S L M D L C Y T S T T V P K M L V N L L S G D K T I S F A G C G A Q L F L Y L T G G T E C L L L A M A Y D R Y V A I C H P L R Y P V M N P R V C L A A G S W L G S L D S I H T V L T L S L P F C G S R I N H F F C E V P L L K A C A D T S L N E T V F V C C V L M L I P L S L V S Y G I L L A V L R M E G R R K A F S T C S S H L T V V G F Y G A A I Y M Y L Q P K S Y H S P E Q D K V V S L F Y T I L T P M L N P L I Y S L N K E V K G A L R R V L G L L L L L L L L V L L L L L E L L I L R L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UY0	O2	Odorant receptors	Odorant family 2	consOR2	Homo sapiens	S-carvone	-	Gs/β1/γ2	3.2	2024-10-30	doi.org/10.1038/s41586-024-08126-0
	8UY0 (No Gprot)	O2	Odorant receptors	Odorant family 2	consOR2	Homo sapiens	S-carvone	-		3.2	2024-10-30	doi.org/10.1038/s41586-024-08126-0

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Download 8UY0_nogp.zip

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