psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:V419	E:E:V466	4.81	No	No	0	0	0
2	E:E:S425	E:E:T421	6.4	No	No	0	0	0
3	E:E:T421	E:E:V426	1.59	No	No	0	0	0
4	E:E:A424	E:E:D422	3.09	No	No	0	0	0
5	E:E:D422	E:E:S425	2.94	No	No	0	0	0
6	E:E:M423	E:E:V426	3.04	No	No	2	0	0
7	E:E:M423	E:E:Y478	9.58	No	Yes	2	0	0
8	E:E:A424	E:E:K428	3.21	No	No	0	0	0
9	E:E:V426	E:E:Y478	10.09	No	Yes	2	0	0
10	E:E:L487	E:E:T427	13.27	Yes	No	0	0	0
11	E:E:A429	E:E:M430	1.61	No	No	0	0	0
12	E:E:M430	E:E:W461	6.98	No	Yes	0	0	0
13	E:E:F505	E:E:M430	8.71	Yes	No	0	0	0
14	E:E:A432	E:E:P433	1.87	No	No	0	0	0
15	E:E:A432	E:E:S435	3.42	No	Yes	0	0	0
16	E:E:G436	E:E:S435	1.86	No	Yes	17	0	0
17	E:E:L437	E:E:S435	4.5	Yes	Yes	0	0	0
18	E:E:S435	E:E:W461	4.94	Yes	Yes	17	0	0
19	E:E:G436	E:E:W461	4.22	No	Yes	17	0	0
20	E:E:D457	E:E:L437	2.71	No	Yes	0	0	0
21	E:E:F505	E:E:L437	2.44	Yes	Yes	0	0	0
22	E:E:R440	E:E:R442	6.4	No	No	0	0	0
23	E:E:D441	E:E:P450	1.61	No	No	0	0	0
24	E:E:D441	E:E:N451	6.73	No	No	0	0	0
25	E:E:R442	E:E:Y502	9.26	No	Yes	0	0	0
26	E:E:V492	E:E:W444	2.45	Yes	Yes	2	0	0
27	E:E:W444	E:E:Y502	2.89	Yes	Yes	0	0	0
28	E:E:W444	R:R:K334	5.8	Yes	Yes	2	0	8
29	E:E:W444	R:R:I416	2.35	Yes	No	2	0	8
30	E:E:L445	R:R:L430	2.77	No	No	0	0	8
31	E:E:K446	R:R:K429	5.75	No	No	0	0	8
32	E:E:I449	E:E:P450	3.39	Yes	No	0	0	0
33	E:E:A452	E:E:I449	3.25	No	Yes	0	0	0
34	E:E:I449	E:E:Y502	4.84	Yes	Yes	0	0	0
35	E:E:A452	E:E:V504	1.7	No	No	0	0	0
36	E:E:F453	E:E:V458	3.93	Yes	Yes	2	0	0
37	E:E:F453	E:E:I488	3.77	Yes	Yes	2	0	0
38	E:E:F453	E:E:Y503	4.13	Yes	Yes	2	0	0
39	E:E:F453	E:E:F505	15	Yes	Yes	2	0	0
40	E:E:L454	E:E:Y502	2.34	No	Yes	0	0	0
41	E:E:G455	E:E:V458	3.68	No	Yes	0	0	0
42	E:E:E499	E:E:S456	8.62	No	No	0	0	0
43	E:E:L462	E:E:V458	2.98	No	Yes	0	0	0
44	E:E:A479	E:E:V458	1.7	No	Yes	0	0	0
45	E:E:I488	E:E:V458	3.07	Yes	Yes	2	0	0
46	E:E:D460	E:E:V459	2.92	No	Yes	2	0	0
47	E:E:A475	E:E:V459	1.7	No	Yes	0	0	0
48	E:E:E499	E:E:V459	9.98	No	Yes	2	0	0
49	E:E:D460	E:E:H464	2.52	No	No	0	0	0
50	E:E:D460	E:E:E499	3.9	No	No	2	0	0
51	E:E:H465	E:E:W461	16.93	No	Yes	0	0	0
52	E:E:L462	E:E:Y478	9.38	No	Yes	0	0	0
53	E:E:H464	E:E:Y463	13.07	No	No	0	0	0
54	E:E:F469	E:E:V466	6.55	Yes	No	0	0	0
55	E:E:E467	E:E:G468	3.27	No	No	0	0	0
56	E:E:F469	E:E:P470	5.78	Yes	No	18	0	0
57	E:E:E474	E:E:F469	4.66	No	Yes	18	0	0
58	E:E:E474	E:E:P470	11	No	No	18	0	0
59	E:E:E471	E:E:R473	3.49	No	No	0	0	0
60	E:E:R472	E:E:R473	2.13	No	No	0	0	0
61	E:E:R473	E:E:R476	3.2	No	No	0	0	0
62	E:E:K477	E:E:R476	17.33	No	No	0	0	0
63	E:E:L482	E:E:Y478	23.45	Yes	Yes	2	0	0
64	E:E:L487	E:E:Y478	5.86	Yes	Yes	2	0	0
65	E:E:A479	E:E:L482	1.58	No	Yes	0	0	0
66	E:E:A479	E:E:F497	6.93	No	Yes	0	0	0
67	E:E:G481	E:E:S480	1.86	No	No	0	0	0
68	E:E:G481	E:E:K484	3.49	No	No	0	0	0
69	E:E:L482	E:E:L487	16.61	Yes	Yes	2	0	0
70	E:E:I488	E:E:L482	12.85	Yes	Yes	2	0	0
71	E:E:I488	E:E:L483	2.85	Yes	No	2	0	0
72	E:E:F497	E:E:L483	6.09	Yes	No	2	0	0
73	E:E:L483	E:E:Y503	2.34	No	Yes	2	0	0
74	E:E:F505	E:E:L487	2.44	Yes	Yes	2	0	0
75	E:E:I488	E:E:Y503	6.04	Yes	Yes	2	0	0
76	E:E:F505	E:E:I488	3.77	Yes	Yes	2	0	0
77	E:E:H490	E:E:V492	6.92	Yes	Yes	2	0	0
78	E:E:H490	E:E:K494	10.48	Yes	No	0	0	0
79	E:E:C501	E:E:H490	2.95	Yes	Yes	2	0	0
80	E:E:H490	E:E:Y503	5.44	Yes	Yes	2	0	0
81	E:E:V492	R:R:K334	3.04	Yes	Yes	2	0	8
82	E:E:V492	R:R:I416	3.07	Yes	No	2	0	8
83	E:E:V492	R:R:L420	4.47	Yes	No	2	0	6
84	E:E:I495	E:E:T496	3.04	No	No	0	0	0
85	E:E:F497	E:E:Y503	18.57	Yes	Yes	2	0	0
86	E:E:Q500	E:E:S498	2.89	No	No	0	0	0
87	E:E:C501	E:E:S498	5.16	Yes	No	0	0	0
88	E:E:Q500	R:R:A339	3.03	No	No	0	0	8
89	E:E:C501	E:E:Y503	2.69	Yes	Yes	2	0	0
90	E:E:C501	R:R:K334	1.62	Yes	Yes	2	0	8
91	E:E:Y502	R:R:H337	2.18	Yes	No	0	0	6
92	E:E:D507	E:E:G506	1.68	No	No	0	0	0
93	R:R:K203	R:R:Q190	14.92	No	No	0	5	3
94	R:R:G209	R:R:Q190	4.93	No	No	0	6	3
95	R:R:C200	R:R:Y191	9.41	No	No	0	9	3
96	R:R:L198	R:R:W193	4.56	No	No	0	3	3
97	R:R:C200	R:R:W193	3.92	No	No	0	9	3
98	R:R:S197	R:R:V194	6.46	No	Yes	10	4	5
99	R:R:N199	R:R:V194	2.96	No	Yes	10	5	5
100	R:R:V194	R:R:V201	4.81	Yes	Yes	10	5	6
101	R:R:V194	R:R:V291	1.6	Yes	No	10	5	4
102	R:R:Q294	R:R:V194	7.16	Yes	Yes	10	6	5
103	R:R:N199	R:R:S197	5.96	No	No	10	5	4
104	R:R:Q294	R:R:S197	4.33	Yes	No	10	6	4
105	R:R:N199	R:R:Q294	11.88	No	Yes	10	5	6
106	R:R:V201	R:R:V291	4.81	Yes	No	10	6	4
107	R:R:L292	R:R:V201	4.47	No	Yes	0	5	6
108	R:R:Q294	R:R:V201	4.3	Yes	Yes	10	6	6
109	R:R:L202	R:R:L210	2.77	No	No	0	4	4
110	R:R:E372	R:R:L202	3.98	No	No	0	6	4
111	R:R:A208	R:R:K203	6.42	No	No	0	4	5
112	R:R:C204	R:R:S281	1.72	Yes	No	0	8	7
113	R:R:C204	R:R:C282	7.28	Yes	No	19	8	9
114	R:R:C204	R:R:P290	1.88	Yes	No	19	8	3
115	R:R:C204	R:R:L292	3.17	Yes	No	0	8	5
116	R:R:A208	R:R:G205	1.95	No	No	0	4	3
117	R:R:E278	R:R:G205	1.64	No	No	0	5	3
118	R:R:C282	R:R:G205	1.96	No	No	0	9	3
119	R:R:D207	R:R:Y206	2.3	No	Yes	7	4	4
120	R:R:R213	R:R:Y206	2.06	No	Yes	7	1	4
121	R:R:K216	R:R:Y206	3.58	No	Yes	7	6	4
122	R:R:D220	R:R:Y206	5.75	No	Yes	7	6	4
123	R:R:R277	R:R:Y206	13.38	Yes	Yes	7	6	4
124	R:R:E278	R:R:Y206	5.61	No	Yes	7	5	4
125	R:R:D207	R:R:R213	7.15	No	No	7	4	1
126	R:R:A208	R:R:G209	1.95	No	No	0	4	6
127	R:R:E372	R:R:G209	1.64	No	No	0	6	6
128	R:R:L210	R:R:Y211	2.34	No	No	0	4	7
129	R:R:A469	R:R:L210	1.58	No	No	0	4	4
130	R:R:E372	R:R:Y211	10.1	No	No	0	6	7
131	R:R:L373	R:R:Y211	10.55	No	No	0	8	7
132	R:R:S212	R:R:S214	4.89	No	No	0	4	3
133	R:R:A215	R:R:S212	1.71	No	No	0	6	4
134	R:R:A215	R:R:M474	1.61	No	No	0	6	4
135	R:R:K216	R:R:R277	16.09	No	Yes	7	6	6
136	R:R:E217	R:R:I221	8.2	No	No	0	3	1
137	R:R:F218	R:R:W222	2	No	Yes	0	5	8
138	R:R:L373	R:R:T219	4.42	No	No	0	8	5
139	R:R:D220	R:R:R272	5.96	No	Yes	7	6	8
140	R:R:D220	R:R:R277	4.76	No	Yes	7	6	6
141	R:R:W222	R:R:W226	24.37	Yes	No	20	8	5
142	R:R:M478	R:R:W222	18.61	No	Yes	0	6	8
143	R:R:F482	R:R:W222	5.01	No	Yes	20	7	8
144	R:R:M223	R:R:Y269	4.79	No	No	0	6	6
145	R:R:M223	R:R:R272	8.69	No	Yes	0	6	8
146	R:R:A224	R:R:L273	1.58	No	No	0	4	5
147	R:R:F482	R:R:W226	15.03	No	No	20	7	5
148	R:R:I489	R:R:W226	2.35	No	No	0	8	5
149	R:R:A227	R:R:S266	1.71	No	No	0	7	8
150	R:R:A227	R:R:Y269	2.67	No	No	0	7	6
151	R:R:C230	R:R:T234	1.69	Yes	Yes	0	7	8
152	R:R:C230	R:R:S266	5.16	Yes	No	0	7	8
153	R:R:C230	R:R:L485	3.17	Yes	No	0	7	8
154	R:R:C230	R:R:G488	1.96	Yes	No	0	7	9
155	R:R:C230	R:R:I489	1.64	Yes	No	0	7	8
156	R:R:A235	R:R:F231	2.77	No	Yes	0	5	4
157	R:R:F231	R:R:N263	7.25	Yes	No	21	4	5
158	R:R:F231	R:R:S266	5.28	Yes	No	0	4	8
159	R:R:F231	R:R:I267	5.02	Yes	No	21	4	4
160	R:R:F231	R:R:I270	3.77	Yes	No	0	4	5
161	R:R:S259	R:R:T234	1.6	No	Yes	0	8	8
162	R:R:N263	R:R:T234	4.39	No	Yes	0	5	8
163	R:R:S491	R:R:T234	3.2	No	Yes	0	8	8
164	R:R:F236	R:R:T240	7.78	No	Yes	8	5	9
165	R:R:F236	R:R:I495	2.51	No	Yes	8	5	7
166	R:R:F236	R:R:W504	12.03	No	Yes	8	5	9
167	R:R:T237	R:R:T240	3.14	Yes	Yes	8	8	9
168	R:R:S259	R:R:T237	6.4	No	Yes	0	8	8
169	R:R:G492	R:R:T237	1.82	No	Yes	8	7	8
170	R:R:I495	R:R:T237	7.6	Yes	Yes	8	7	8
171	R:R:S259	R:R:V238	3.23	No	No	0	8	6
172	R:R:L239	R:R:W504	3.42	No	Yes	0	5	9
173	R:R:I495	R:R:T240	4.56	Yes	Yes	8	7	9
174	R:R:T240	R:R:T500	3.14	Yes	Yes	8	9	8
175	R:R:T240	R:R:W504	6.06	Yes	Yes	8	9	9
176	R:R:F241	R:R:L242	2.44	No	No	0	8	5
177	R:R:F241	R:R:S245	3.96	No	No	0	8	6
178	R:R:F241	R:R:I256	18.84	No	No	0	8	7
179	R:R:I243	R:R:W504	3.52	No	Yes	0	6	9
180	R:R:D244	R:R:S246	5.89	No	No	0	8	4
181	R:R:F248	R:R:R247	14.97	No	No	0	8	9
182	R:R:R247	R:R:T500	2.59	No	Yes	0	9	8
183	R:R:F248	R:R:I256	6.28	No	No	0	8	7
184	R:R:F248	R:R:I495	2.51	No	Yes	0	8	7
185	R:R:R253	R:R:Y250	6.17	No	Yes	0	9	9
186	R:R:T326	R:R:Y250	3.75	No	Yes	22	8	9
187	R:R:I340	R:R:Y250	4.84	No	Yes	22	9	9
188	R:R:F347	R:R:Y250	8.25	No	Yes	0	8	9
189	R:R:P251	R:R:T326	3.5	No	No	0	9	8
190	R:R:P251	R:R:W327	4.05	No	Yes	0	9	9
191	R:R:A330	R:R:P251	1.87	No	No	0	8	9
192	R:R:E252	R:R:W327	2.18	No	Yes	4	9	9
193	R:R:E252	R:R:W494	3.27	No	Yes	4	9	9
194	R:R:P254	R:R:W319	5.4	No	Yes	0	8	9
195	R:R:L323	R:R:P254	6.57	Yes	No	0	9	8
196	R:R:I255	R:R:L323	5.71	No	Yes	0	8	9
197	R:R:F440	R:R:I255	2.51	Yes	No	4	9	8
198	R:R:I255	R:R:W494	8.22	No	Yes	4	8	9
199	R:R:F257	R:R:W319	21.05	No	Yes	15	7	9
200	R:R:F257	R:R:H348	6.79	No	Yes	15	7	9
201	R:R:F257	R:R:W352	2	No	Yes	15	7	9
202	R:R:L258	R:R:W320	2.28	No	Yes	4	7	9
203	R:R:F440	R:R:L258	2.44	Yes	No	4	9	7
204	R:R:C261	R:R:F312	5.59	No	Yes	0	8	8
205	R:R:A315	R:R:C261	1.81	No	No	0	9	8
206	R:R:C261	R:R:S316	1.72	No	No	0	8	8
207	R:R:S316	R:R:Y262	10.17	No	Yes	0	8	8
208	R:R:Y262	R:R:Y444	1.99	Yes	Yes	4	8	8
209	R:R:V487	R:R:Y262	7.57	No	Yes	4	8	8
210	R:R:G488	R:R:Y262	4.35	No	Yes	0	9	8
211	R:R:I267	R:R:N263	2.83	No	No	21	4	5
212	R:R:F312	R:R:I264	20.09	Yes	No	0	8	5
213	R:R:Y265	R:R:Y269	9.93	No	No	0	7	6
214	R:R:L309	R:R:Y265	7.03	Yes	No	0	6	7
215	R:R:S484	R:R:Y265	5.09	No	No	0	6	7
216	R:R:A268	R:R:I305	1.62	No	No	23	6	7
217	R:R:A268	R:R:L308	3.15	No	No	0	6	5
218	R:R:A268	R:R:L309	3.15	No	Yes	23	6	6
219	R:R:V271	R:R:V275	1.6	No	Yes	0	4	4
220	R:R:I305	R:R:V271	3.07	No	No	0	7	4
221	R:R:L273	R:R:R272	4.86	No	Yes	0	5	8
222	R:R:R272	R:R:R277	4.26	Yes	Yes	7	8	6
223	R:R:L376	R:R:R272	2.43	No	Yes	0	7	8
224	R:R:T274	R:R:V275	1.59	No	Yes	0	3	4
225	R:R:R279	R:R:V275	2.62	No	Yes	0	3	4
226	R:R:I280	R:R:V275	6.14	No	Yes	0	6	4
227	R:R:E278	R:R:R277	2.33	No	Yes	7	5	6
228	R:R:N299	R:R:R279	8.44	No	No	0	7	3
229	R:R:R279	S:S:K298	14.85	No	No	0	3	5
230	R:R:G301	R:R:I280	1.76	No	No	0	4	6
231	R:R:C302	R:R:I280	1.64	No	No	0	9	6
232	R:R:G375	R:R:S281	1.86	No	No	0	9	7
233	R:R:C282	R:R:P290	3.77	No	No	19	9	3
234	R:R:E289	R:R:P290	3.14	No	No	0	3	3
235	R:R:G296	R:R:I293	1.76	No	No	0	6	6
236	R:R:C302	R:R:G296	1.96	No	No	0	9	6
237	R:R:A303	R:R:L297	1.58	No	No	0	8	6
238	R:R:N299	R:R:T300	2.92	No	No	24	7	5
239	R:R:G301	R:R:N299	1.7	No	No	24	4	7
240	R:R:G301	R:R:T300	3.64	No	No	24	4	5
241	R:R:T300	S:S:A303	1.68	No	No	0	5	8
242	R:R:C302	R:R:C377	7.28	No	No	0	9	9
243	R:R:I304	R:R:L308	2.85	No	No	0	5	5
244	R:R:I305	R:R:L309	2.85	No	Yes	23	7	6
245	R:R:F306	R:R:L307	3.65	Yes	No	0	9	7
246	R:R:F306	R:R:I362	7.54	Yes	No	0	9	6
247	R:R:F306	R:R:L363	3.65	Yes	No	0	9	8
248	R:R:F306	R:R:V368	13.11	Yes	No	0	9	8
249	R:R:F306	R:R:V379	3.93	Yes	Yes	0	9	8
250	R:R:F312	R:R:L308	2.44	Yes	No	0	8	5
251	R:R:L309	R:R:Y378	4.69	Yes	No	0	6	6
252	R:R:M314	R:R:Y310	4.79	Yes	Yes	0	8	9
253	R:R:K358	R:R:Y310	2.39	No	Yes	0	7	9
254	R:R:I362	R:R:Y310	8.46	No	Yes	9	6	9
255	R:R:Y310	R:R:Y378	2.98	Yes	No	0	9	6
256	R:R:V379	R:R:Y310	5.05	Yes	Yes	9	8	9
257	R:R:F390	R:R:Y310	5.16	No	Yes	9	8	9
258	R:R:F311	R:R:F312	7.5	Yes	Yes	0	9	8
259	R:R:F311	R:R:W352	3.01	Yes	Yes	0	9	9
260	R:R:F311	R:R:P355	2.89	Yes	Yes	0	9	9
261	R:R:G313	R:R:S316	1.86	No	No	0	5	8
262	R:R:M314	R:R:P355	1.68	Yes	Yes	0	8	9
263	R:R:M314	R:R:P394	1.68	Yes	No	0	8	9
264	R:R:L395	R:R:M314	2.83	No	Yes	0	7	8
265	R:R:A315	R:R:W352	3.89	No	Yes	0	9	9
266	R:R:S317	R:R:Y398	6.36	No	Yes	0	6	6
267	R:R:S317	R:R:Y444	2.54	No	Yes	0	6	8
268	R:R:A351	R:R:I318	1.62	No	Yes	0	9	5
269	R:R:I318	R:R:I354	5.89	Yes	Yes	25	5	4
270	R:R:I318	R:R:P355	1.69	Yes	Yes	25	5	9
271	R:R:I318	R:R:Y398	7.25	Yes	Yes	0	5	6
272	R:R:H348	R:R:W319	4.23	Yes	Yes	15	9	9
273	R:R:A351	R:R:W319	5.19	No	Yes	0	9	9
274	R:R:W319	R:R:W352	6.56	Yes	Yes	15	9	9
275	R:R:L323	R:R:W320	2.28	Yes	Yes	0	9	9
276	R:R:T324	R:R:W320	7.28	Yes	Yes	4	8	9
277	R:R:G402	R:R:W320	4.22	No	Yes	4	9	9
278	R:R:F440	R:R:W320	6.01	Yes	Yes	4	9	9
279	R:R:W320	R:R:Y444	20.26	Yes	Yes	4	9	8
280	R:R:V321	R:R:Y398	3.79	No	Yes	0	9	6
281	R:R:F347	R:R:I322	5.02	No	No	0	8	7
282	R:R:A351	R:R:I322	1.62	No	No	0	9	7
283	R:R:L323	R:R:W327	6.83	Yes	Yes	0	9	9
284	R:R:G402	R:R:T324	5.46	No	Yes	4	9	8
285	R:R:F405	R:R:T324	2.59	Yes	Yes	0	8	8
286	R:R:I406	R:R:T324	4.56	No	Yes	0	8	8
287	R:R:F405	R:R:L325	3.65	Yes	No	0	8	6
288	R:R:I340	R:R:T326	3.04	No	No	22	9	8
289	R:R:L433	R:R:W327	3.42	No	Yes	4	8	9
290	R:R:I437	R:R:W327	3.52	Yes	Yes	4	8	9
291	R:R:W327	R:R:W494	5.62	Yes	Yes	4	9	9
292	R:R:F328	R:R:L333	3.65	No	No	0	7	6
293	R:R:F328	R:R:F405	4.29	No	Yes	0	7	8
294	R:R:L329	R:R:W335	6.83	No	No	0	8	8
295	R:R:A331	R:R:G332	1.95	No	No	0	8	7
296	R:R:A331	R:R:L413	1.58	No	No	0	8	8
297	R:R:G332	R:R:K334	3.49	No	Yes	0	7	8
298	R:R:A412	R:R:G332	1.95	No	No	0	7	7
299	R:R:L333	R:R:W335	5.69	No	No	0	6	8
300	R:R:A339	R:R:W335	5.19	No	No	0	8	8
301	R:R:E338	R:R:G336	1.64	No	No	0	9	7
302	R:R:E338	R:R:H337	20.92	No	No	0	9	6
303	R:R:H343	R:R:M342	2.63	No	No	0	6	5
304	R:R:S345	R:R:Y346	3.82	No	No	0	6	6
305	R:R:H348	R:R:W352	6.35	Yes	Yes	15	9	9
306	R:R:A350	R:R:I354	1.62	No	Yes	0	5	4
307	R:R:I354	R:R:P355	5.08	Yes	Yes	25	4	9
308	R:R:I354	R:R:K358	2.91	Yes	No	0	4	7
309	R:R:V357	R:R:V361	1.6	No	No	0	4	4
310	R:R:I360	R:R:I364	2.94	No	No	0	7	7
311	R:R:F390	R:R:I362	7.54	No	No	9	8	6
312	R:R:L367	R:R:M365	5.65	No	No	0	6	5
313	R:R:C377	R:R:V368	1.71	No	No	0	9	8
314	R:R:D369	R:R:Q382	6.53	No	No	0	8	5
315	R:R:A370	R:R:C377	3.61	No	No	0	8	9
316	R:R:D371	R:R:T374	8.67	No	No	0	9	8
317	R:R:D371	R:R:N381	5.39	No	No	0	9	7
318	R:R:E477	R:R:L373	2.65	No	No	0	6	8
319	R:R:G375	R:R:T374	1.82	No	No	0	9	8
320	R:R:L376	R:R:T374	4.42	No	No	0	7	8
321	R:R:G380	R:R:V379	1.84	No	Yes	9	9	8
322	R:R:A386	R:R:V379	1.7	No	Yes	9	5	8
323	R:R:F390	R:R:V379	2.62	No	Yes	9	8	8
324	R:R:G380	R:R:N383	1.7	No	Yes	9	9	6
325	R:R:A386	R:R:G380	1.95	No	No	9	5	9
326	R:R:N381	R:R:Q382	2.64	No	No	0	7	5
327	R:R:Q382	R:R:R466	2.34	No	Yes	0	5	4
328	R:R:D385	R:R:N383	4.04	No	Yes	0	2	6
329	R:R:A386	R:R:N383	4.69	No	Yes	9	5	6
330	R:R:L384	R:R:W462	25.06	No	No	0	2	7
331	R:R:D385	R:R:T388	2.89	No	No	0	2	6
332	R:R:L387	R:R:V391	4.47	No	No	11	8	7
333	R:R:L387	R:R:Y455	2.34	No	Yes	11	8	4
334	R:R:L387	R:R:W462	2.28	No	No	0	8	7
335	R:R:G389	R:R:T388	3.64	No	No	0	1	6
336	R:R:V391	R:R:V392	1.6	No	Yes	11	7	6
337	R:R:V391	R:R:Y455	5.05	No	Yes	11	7	4
338	R:R:I452	R:R:V392	3.07	No	Yes	11	6	6
339	R:R:F456	R:R:V392	2.62	No	Yes	11	4	6
340	R:R:A393	R:R:P394	1.87	No	No	0	4	9
341	R:R:P394	R:R:Y398	5.56	No	Yes	0	9	6
342	R:R:F396	R:R:V400	3.93	No	No	0	2	3
343	R:R:L399	R:R:T403	2.95	No	No	0	8	5
344	R:R:G402	R:R:I401	1.76	No	No	0	9	4
345	R:R:F405	R:R:I401	2.51	Yes	No	0	8	4
346	R:R:I406	R:R:I437	2.94	No	Yes	0	8	8
347	R:R:A408	R:R:G409	1.95	No	No	0	5	9
348	R:R:L410	R:R:L413	2.77	No	No	0	7	8
349	R:R:L413	R:R:M434	11.31	No	No	0	8	8
350	R:R:K415	R:R:N419	2.8	No	No	0	7	5
351	R:R:I416	R:R:L420	4.28	No	No	2	8	6
352	R:R:R417	R:R:T427	9.06	No	No	0	8	6
353	R:R:L430	R:R:R417	4.86	No	No	0	8	8
354	R:R:E431	R:R:R417	8.14	No	No	0	8	8
355	R:R:N419	R:R:S418	5.96	No	No	0	5	5
356	R:R:K426	R:R:T425	12.01	No	No	0	7	5
357	R:R:D428	R:R:K429	8.3	No	No	0	4	8
358	R:R:D428	R:R:E431	2.6	No	No	0	4	8
359	R:R:L430	R:R:M434	7.07	No	No	0	8	8
360	R:R:I437	R:R:L433	2.85	Yes	No	4	8	8
361	R:R:V435	R:R:V439	1.6	No	No	0	6	5
362	R:R:K436	R:R:W494	8.12	No	Yes	0	9	9
363	R:R:G438	R:R:I437	1.76	No	Yes	0	8	8
364	R:R:G438	R:R:S441	3.71	No	No	0	8	8
365	R:R:M493	R:R:V439	4.56	No	No	0	6	5
366	R:R:F440	R:R:M493	3.73	Yes	No	0	9	6
367	R:R:F440	R:R:W494	8.02	Yes	Yes	4	9	9
368	R:R:S441	R:R:V442	1.62	No	No	0	8	5
369	R:R:V442	R:R:V446	1.6	No	Yes	0	5	6
370	R:R:L443	R:R:T490	8.84	No	No	0	8	7
371	R:R:L443	R:R:M493	2.83	No	No	0	8	6
372	R:R:V487	R:R:Y444	2.52	No	Yes	4	8	8
373	R:R:T445	R:R:V446	1.59	No	Yes	0	7	6
374	R:R:P447	R:R:V446	3.53	No	Yes	0	8	6
375	R:R:I450	R:R:V446	3.07	No	Yes	0	4	6
376	R:R:M483	R:R:P447	1.68	No	No	0	9	8
377	R:R:P447	R:R:V487	3.53	No	No	0	8	8
378	R:R:C454	R:R:I450	1.64	No	No	0	6	4
379	R:R:I450	R:R:M483	5.83	No	No	0	4	9
380	R:R:V451	R:R:Y455	2.52	No	Yes	0	7	4
381	R:R:F456	R:R:I452	6.28	No	No	11	4	6
382	R:R:C454	R:R:L479	1.59	No	No	0	6	6
383	R:R:C454	R:R:K480	3.23	No	No	0	6	8
384	R:R:K480	R:R:Y455	19.11	No	Yes	0	8	4
385	R:R:N461	R:R:Y457	8.14	No	No	0	5	8
386	R:R:F465	R:R:Y457	5.16	Yes	No	16	8	8
387	R:R:V476	R:R:Y457	2.52	Yes	No	16	6	8
388	R:R:E458	R:R:F465	13.99	No	Yes	16	9	8
389	R:R:E458	R:R:V476	4.28	No	Yes	16	9	6
390	R:R:E458	R:R:E477	5.07	No	No	0	9	6
391	R:R:N461	R:R:S460	4.47	No	No	0	5	3
392	R:R:L464	R:R:N461	6.87	No	No	0	1	5
393	R:R:R466	R:R:W462	13.99	Yes	No	0	4	7
394	R:R:F465	R:R:R466	4.28	Yes	Yes	0	8	4
395	R:R:F465	R:R:N473	25.37	Yes	No	0	8	5
396	R:R:F465	R:R:V476	7.87	Yes	Yes	16	8	6
397	R:R:D470	R:R:S472	5.89	No	No	0	2	8
398	R:R:D470	R:R:N473	2.69	No	No	0	2	5
399	R:R:S472	R:R:V476	1.62	No	Yes	0	8	6
400	R:R:L479	R:R:M483	5.65	No	No	0	6	9
401	R:R:G488	R:R:S491	3.71	No	No	0	9	8
402	R:R:G492	R:R:I495	1.76	No	Yes	8	7	7
403	R:R:G492	R:R:W496	5.63	No	No	8	7	6
404	R:R:I495	R:R:W496	3.52	Yes	No	8	7	6
405	R:R:K499	R:R:S497	4.59	No	No	0	9	9
406	R:R:S497	R:R:T500	6.4	No	Yes	0	9	8
407	R:R:A498	R:R:H502	2.93	No	Yes	0	4	4
408	R:R:T500	R:R:W504	2.43	Yes	Yes	8	8	9
409	R:R:H502	R:R:Q505	6.18	Yes	No	0	4	5
410	R:R:H502	R:R:K506	2.62	Yes	No	0	4	3
411	R:R:F507	R:R:Y508	2.06	No	No	0	5	3
412	R:R:N513	R:R:V512	2.96	No	No	0	3	2
413	S:S:S188	S:S:Y191	8.9	No	No	0	1	3
414	S:S:S197	S:S:V194	8.08	No	No	0	4	5
415	S:S:V194	S:S:V291	3.21	No	No	0	5	4
416	S:S:E289	S:S:K195	10.8	Yes	No	0	3	5
417	S:S:F284	S:S:R196	3.21	No	No	6	1	4
418	S:S:E289	S:S:R196	20.93	Yes	No	6	3	4
419	S:S:C204	S:S:G205	3.92	Yes	Yes	6	8	3
420	S:S:C204	S:S:S281	3.44	Yes	Yes	6	8	7
421	S:S:C204	S:S:C282	7.28	Yes	Yes	6	8	9
422	S:S:C204	S:S:P290	5.65	Yes	Yes	6	8	3
423	S:S:D207	S:S:G205	1.68	No	Yes	0	4	3
424	S:S:G205	S:S:R277	4.5	Yes	Yes	6	3	6
425	S:S:C282	S:S:G205	1.96	Yes	Yes	6	9	3
426	S:S:E278	S:S:Y206	7.86	No	No	0	5	4
427	S:S:D207	S:S:P290	12.88	No	Yes	0	4	3
428	S:S:A208	S:S:G209	1.95	No	No	0	4	6
429	S:S:L210	S:S:Y211	2.34	No	No	0	4	7
430	S:S:E372	S:S:L210	3.98	No	No	0	6	4
431	S:S:L373	S:S:Y211	11.72	Yes	No	26	8	7
432	S:S:M474	S:S:Y211	3.59	Yes	No	26	4	7
433	S:S:S212	S:S:S214	1.63	No	No	0	4	3
434	S:S:A215	S:S:M474	3.22	No	Yes	0	6	4
435	S:S:K216	S:S:R277	16.09	No	Yes	0	6	6
436	S:S:F218	S:S:W222	15.03	No	No	0	5	8
437	S:S:D220	S:S:T219	2.89	No	No	0	6	5
438	S:S:L373	S:S:T219	2.95	Yes	No	0	8	5
439	S:S:M478	S:S:T219	3.01	No	No	0	6	5
440	S:S:D220	S:S:R272	9.53	No	Yes	0	6	8
441	S:S:D220	S:S:L273	4.07	No	No	0	6	5
442	S:S:W222	S:S:W226	16.87	No	Yes	0	8	5
443	S:S:M478	S:S:W222	3.49	No	No	0	6	8
444	S:S:M223	S:S:Y269	5.99	Yes	Yes	0	6	6
445	S:S:M223	S:S:R272	4.96	Yes	Yes	0	6	8
446	S:S:M223	S:S:T374	3.01	Yes	Yes	0	6	8
447	S:S:I481	S:S:M223	2.92	No	Yes	0	7	6
448	S:S:A224	S:S:L273	1.58	No	No	0	4	5
449	S:S:F482	S:S:W226	17.04	No	Yes	0	7	5
450	S:S:L485	S:S:W226	2.28	No	Yes	0	8	5
451	S:S:I489	S:S:W226	3.52	No	Yes	0	8	5
452	S:S:A227	S:S:Y269	2.67	No	Yes	0	7	6
453	S:S:L229	S:S:S228	4.5	No	No	0	5	4
454	S:S:I489	S:S:L229	4.28	No	No	0	8	5
455	S:S:C230	S:S:T234	1.69	Yes	Yes	1	7	8
456	S:S:C230	S:S:S266	1.72	Yes	No	0	7	8
457	S:S:C230	S:S:L485	3.17	Yes	No	0	7	8
458	S:S:C230	S:S:G488	3.92	Yes	Yes	1	7	9
459	S:S:C230	S:S:I489	1.64	Yes	No	0	7	8
460	S:S:A235	S:S:F231	2.77	No	Yes	0	5	4
461	S:S:F231	S:S:N263	9.67	Yes	No	0	4	5
462	S:S:F231	S:S:S266	5.28	Yes	No	0	4	8
463	S:S:F231	S:S:I270	2.51	Yes	No	0	4	5
464	S:S:N263	S:S:T234	8.77	No	Yes	0	5	8
465	S:S:G488	S:S:T234	1.82	Yes	Yes	1	9	8
466	S:S:S491	S:S:T234	4.8	Yes	Yes	1	8	8
467	S:S:F236	S:S:T240	5.19	No	No	1	5	9
468	S:S:F236	S:S:I495	2.51	No	Yes	1	5	7
469	S:S:F236	S:S:W504	2	No	Yes	1	5	9
470	S:S:S259	S:S:T237	6.4	Yes	Yes	1	8	8
471	S:S:S491	S:S:T237	1.6	Yes	Yes	1	8	8
472	S:S:G492	S:S:T237	1.82	No	Yes	1	7	8
473	S:S:I495	S:S:T237	9.12	Yes	Yes	1	7	8
474	S:S:S259	S:S:V238	1.62	Yes	No	0	8	6
475	S:S:I243	S:S:L239	2.85	No	No	1	6	5
476	S:S:L239	S:S:W504	2.28	No	Yes	1	5	9
477	S:S:T240	S:S:W504	9.7	No	Yes	1	9	9
478	S:S:F241	S:S:S245	5.28	No	No	0	8	6
479	S:S:F241	S:S:F248	4.29	No	No	1	8	8
480	S:S:F241	S:S:I256	8.79	No	Yes	1	8	7
481	S:S:I243	S:S:W504	8.22	No	Yes	1	6	9
482	S:S:D244	S:S:S246	5.89	No	No	0	8	4
483	S:S:D244	S:S:R247	5.96	No	Yes	0	8	9
484	S:S:S245	S:S:S246	1.63	No	No	0	6	4
485	S:S:K499	S:S:R247	3.71	No	Yes	0	9	9
486	S:S:R247	S:S:T500	10.35	Yes	No	0	9	8
487	S:S:R247	S:S:T503	3.88	Yes	No	0	9	7
488	S:S:E252	S:S:F248	4.66	No	No	1	9	8
489	S:S:F248	S:S:I256	7.54	No	Yes	1	8	7
490	S:S:H337	S:S:S249	4.18	No	No	0	6	6
491	S:S:R253	S:S:Y250	10.29	No	Yes	13	9	9
492	S:S:P254	S:S:Y250	5.56	No	Yes	0	8	9
493	S:S:T326	S:S:Y250	2.5	No	Yes	13	8	9
494	S:S:I340	S:S:Y250	6.04	No	Yes	13	9	9
495	S:S:E341	S:S:Y250	8.98	No	Yes	13	7	9
496	S:S:P251	S:S:T326	5.25	No	No	0	9	8
497	S:S:A330	S:S:P251	5.61	No	No	0	8	9
498	S:S:I437	S:S:P251	1.69	Yes	No	0	8	9
499	S:S:E252	S:S:L433	6.63	No	No	1	9	8
500	S:S:E252	S:S:W494	17.45	No	Yes	1	9	9
501	S:S:E341	S:S:R253	3.49	No	No	13	7	9
502	S:S:L323	S:S:P254	3.28	No	No	0	9	8
503	S:S:F440	S:S:I255	7.54	No	No	0	9	8
504	S:S:I256	S:S:S259	3.1	Yes	Yes	1	7	8
505	S:S:F257	S:S:W319	12.03	No	Yes	12	7	9
506	S:S:F257	S:S:H348	4.53	No	No	12	7	9
507	S:S:L258	S:S:S316	3	No	No	0	7	8
508	S:S:L258	S:S:W319	2.28	No	Yes	0	7	9
509	S:S:S259	S:S:S491	4.89	Yes	Yes	1	8	8
510	S:S:A315	S:S:C261	1.81	No	No	12	9	8
511	S:S:C261	S:S:W352	2.61	No	Yes	12	8	9
512	S:S:S316	S:S:Y262	8.9	No	No	0	8	8
513	S:S:V487	S:S:Y262	7.57	Yes	No	0	8	8
514	S:S:I264	S:S:I267	2.94	No	No	0	5	4
515	S:S:I264	S:S:L308	2.85	No	No	0	5	5
516	S:S:F312	S:S:I264	13.82	No	No	0	8	5
517	S:S:Y265	S:S:Y269	4.96	Yes	Yes	0	7	6
518	S:S:L309	S:S:Y265	8.21	No	Yes	0	6	7
519	S:S:G313	S:S:Y265	2.9	No	Yes	0	5	7
520	S:S:S484	S:S:Y265	3.82	No	Yes	0	6	7
521	S:S:A268	S:S:I305	1.62	No	No	0	6	7
522	S:S:A268	S:S:L308	3.15	No	No	0	6	5
523	S:S:A268	S:S:L309	3.15	No	No	0	6	6
524	S:S:L485	S:S:Y269	4.69	No	Yes	0	8	6
525	S:S:V271	S:S:V275	1.6	No	Yes	0	4	4
526	S:S:R272	S:S:R277	11.73	Yes	Yes	0	8	6
527	S:S:L376	S:S:R272	2.43	No	Yes	0	7	8
528	S:S:G276	S:S:V275	1.84	No	Yes	0	6	4
529	S:S:R279	S:S:V275	3.92	No	Yes	0	3	4
530	S:S:I280	S:S:V275	7.68	No	Yes	0	6	4
531	S:S:R277	S:S:S281	3.95	Yes	Yes	6	6	7
532	S:S:G375	S:S:R277	3	No	Yes	6	9	6
533	S:S:G301	S:S:I280	3.53	No	No	0	4	6
534	S:S:C302	S:S:I280	1.64	No	No	0	9	6
535	S:S:C282	S:S:S281	3.44	Yes	Yes	6	9	7
536	S:S:G375	S:S:S281	3.71	No	Yes	6	9	7
537	S:S:C282	S:S:P290	3.77	Yes	Yes	6	9	3
538	S:S:D283	S:S:I293	8.4	No	No	0	4	6
539	S:S:E289	S:S:F284	8.16	Yes	No	6	3	1
540	S:S:A370	S:S:L292	1.58	No	No	0	8	5
541	S:S:E372	S:S:L292	2.65	No	No	0	6	5
542	S:S:A370	S:S:I293	1.62	No	No	0	8	6
543	S:S:E295	S:S:K298	9.45	No	No	0	7	5
544	S:S:G296	S:S:L297	1.71	No	Yes	0	6	6
545	S:S:G296	S:S:V368	3.68	No	No	0	6	8
546	S:S:A303	S:S:L297	1.58	No	Yes	0	8	6
547	S:S:L297	S:S:L363	4.15	Yes	No	0	6	8
548	S:S:G301	S:S:N299	1.7	No	No	0	4	7
549	S:S:G301	S:S:T300	3.64	No	No	0	4	5
550	S:S:C302	S:S:C377	7.28	No	No	0	9	9
551	S:S:I304	S:S:L308	2.85	No	No	0	5	5
552	S:S:I305	S:S:L376	2.85	No	No	0	7	7
553	S:S:F306	S:S:Y310	5.16	Yes	Yes	3	9	9
554	S:S:F306	S:S:T359	2.59	Yes	No	0	9	8
555	S:S:F306	S:S:I362	5.02	Yes	Yes	3	9	6
556	S:S:F306	S:S:V368	7.87	Yes	No	0	9	8
557	S:S:F306	S:S:V379	3.93	Yes	Yes	3	9	8
558	S:S:K358	S:S:Y310	3.58	No	Yes	0	7	9
559	S:S:I362	S:S:Y310	4.84	Yes	Yes	3	6	9
560	S:S:Y310	S:S:Y378	3.97	Yes	No	3	9	6
561	S:S:V379	S:S:Y310	2.52	Yes	Yes	3	8	9
562	S:S:F390	S:S:Y310	2.06	No	Yes	3	8	9
563	S:S:F311	S:S:F312	10.72	Yes	No	0	9	8
564	S:S:F311	S:S:W352	4.01	Yes	Yes	0	9	9
565	S:S:F311	S:S:P355	5.78	Yes	Yes	0	9	9
566	S:S:G313	S:S:S316	1.86	No	No	0	5	8
567	S:S:I318	S:S:M314	2.92	Yes	Yes	5	5	8
568	S:S:M314	S:S:P355	6.71	Yes	Yes	5	8	9
569	S:S:K358	S:S:M314	2.88	No	Yes	0	7	8
570	S:S:M314	S:S:Y398	5.99	Yes	Yes	5	8	6
571	S:S:A315	S:S:W352	2.59	No	Yes	12	9	9
572	S:S:S317	S:S:Y398	3.82	No	Yes	0	6	6
573	S:S:A351	S:S:I318	1.62	No	Yes	0	9	5
574	S:S:I318	S:S:I354	4.42	Yes	Yes	5	5	4
575	S:S:I318	S:S:P355	1.69	Yes	Yes	5	5	9
576	S:S:I318	S:S:Y398	4.84	Yes	Yes	5	5	6
577	S:S:I322	S:S:W319	3.52	No	Yes	0	7	9
578	S:S:H348	S:S:W319	7.41	No	Yes	12	9	9
579	S:S:A351	S:S:W319	5.19	No	Yes	0	9	9
580	S:S:W319	S:S:W352	7.5	Yes	Yes	12	9	9
581	S:S:T324	S:S:W320	6.06	Yes	Yes	5	8	9
582	S:S:G402	S:S:W320	4.22	No	Yes	5	9	9
583	S:S:S441	S:S:W320	3.71	No	Yes	5	8	9
584	S:S:W320	S:S:Y444	26.04	Yes	No	0	9	8
585	S:S:T445	S:S:W320	2.43	No	Yes	0	7	9
586	S:S:T324	S:S:V321	1.59	Yes	No	5	8	9
587	S:S:V321	S:S:Y398	3.79	No	Yes	5	9	6
588	S:S:I401	S:S:V321	4.61	Yes	No	5	4	9
589	S:S:F347	S:S:I322	3.77	No	No	0	8	7
590	S:S:G402	S:S:T324	1.82	No	Yes	5	9	8
591	S:S:F405	S:S:T324	3.89	Yes	Yes	0	8	8
592	S:S:S441	S:S:T324	1.6	No	Yes	5	8	8
593	S:S:L325	S:S:L329	2.77	No	No	0	6	8
594	S:S:F405	S:S:L325	3.65	Yes	No	0	8	6
595	S:S:I340	S:S:T326	3.04	No	No	13	9	8
596	S:S:A331	S:S:W327	2.59	Yes	Yes	1	8	9
597	S:S:I406	S:S:W327	4.7	No	Yes	0	8	9
598	S:S:M434	S:S:W327	3.49	No	Yes	1	8	9
599	S:S:I437	S:S:W327	8.22	Yes	Yes	1	8	9
600	S:S:F328	S:S:G332	3.01	No	No	0	7	7
601	S:S:F328	S:S:F405	4.29	No	Yes	0	7	8
602	S:S:L329	S:S:W335	9.11	No	No	0	8	8
603	S:S:A330	S:S:I340	1.62	No	No	0	8	9
604	S:S:A331	S:S:G332	1.95	Yes	No	1	8	7
605	S:S:A331	S:S:L413	4.73	Yes	No	1	8	8
606	S:S:A331	S:S:M434	1.61	Yes	No	1	8	8
607	S:S:G332	S:S:L413	1.71	No	No	1	7	8
608	S:S:L333	S:S:W335	5.69	No	No	0	6	8
609	S:S:A339	S:S:W335	2.59	No	No	0	8	8
610	S:S:E338	S:S:G336	1.64	No	No	0	9	7
611	S:S:E338	S:S:H337	22.16	No	No	0	9	6
612	S:S:H343	S:S:M342	18.38	No	No	0	6	5
613	S:S:H343	S:S:Y346	6.53	No	No	0	6	6
614	S:S:S345	S:S:Y346	7.63	No	No	0	6	6
615	S:S:H348	S:S:W352	8.46	No	Yes	12	9	9
616	S:S:A350	S:S:I354	1.62	No	Yes	0	5	4
617	S:S:I354	S:S:P355	3.39	Yes	Yes	5	4	9
618	S:S:I354	S:S:K358	4.36	Yes	No	0	4	7
619	S:S:V357	S:S:V361	1.6	No	No	0	4	4
620	S:S:I362	S:S:V379	6.14	Yes	Yes	3	6	8
621	S:S:F390	S:S:I362	12.56	No	Yes	3	8	6
622	S:S:I364	S:S:M365	2.92	No	No	0	7	5
623	S:S:L367	S:S:M365	2.83	No	No	0	6	5
624	S:S:A386	S:S:L367	1.58	No	No	0	5	6
625	S:S:F390	S:S:L367	2.44	No	No	0	8	6
626	S:S:C377	S:S:V368	1.71	No	No	0	9	8
627	S:S:D369	S:S:N381	4.04	No	No	3	8	7
628	S:S:D369	S:S:Q382	6.53	No	No	3	8	5
629	S:S:A370	S:S:C377	1.81	No	No	0	8	9
630	S:S:D371	S:S:T374	5.78	No	Yes	0	9	8
631	S:S:D371	S:S:N381	4.04	No	No	0	9	7
632	S:S:L373	S:S:M474	4.24	Yes	Yes	26	8	4
633	S:S:E477	S:S:L373	2.65	No	Yes	0	6	8
634	S:S:G375	S:S:T374	1.82	No	Yes	0	9	8
635	S:S:L376	S:S:T374	4.42	No	Yes	0	7	8
636	S:S:V379	S:S:Y378	5.05	Yes	No	3	8	6
637	S:S:V391	S:S:Y378	5.05	Yes	No	3	7	6
638	S:S:G380	S:S:V379	1.84	No	Yes	0	9	8
639	S:S:V379	S:S:V391	1.6	Yes	Yes	3	8	7
640	S:S:A386	S:S:G380	1.95	No	No	0	5	9
641	S:S:G380	S:S:L387	1.71	No	No	0	9	8
642	S:S:N381	S:S:Q382	2.64	No	No	3	7	5
643	S:S:Q382	S:S:R466	8.18	No	Yes	3	5	4
644	S:S:A386	S:S:N383	6.25	No	No	0	5	6
645	S:S:L384	S:S:T388	2.95	No	No	0	2	6
646	S:S:L384	S:S:W462	13.67	No	No	0	2	7
647	S:S:L387	S:S:V391	4.47	No	Yes	0	8	7
648	S:S:V391	S:S:V392	1.6	Yes	No	3	7	6
649	S:S:V391	S:S:Y455	5.05	Yes	Yes	3	7	4
650	S:S:V392	S:S:Y455	2.52	No	Yes	3	6	4
651	S:S:F456	S:S:V392	3.93	No	No	0	4	6
652	S:S:A393	S:S:P394	1.87	No	No	0	4	9
653	S:S:P394	S:S:Y398	2.78	No	Yes	0	9	6
654	S:S:L395	S:S:Y455	2.34	No	Yes	0	7	4
655	S:S:F396	S:S:V400	2.62	No	No	0	2	3
656	S:S:F396	S:S:F456	4.29	No	No	0	2	4
657	S:S:I401	S:S:Y398	2.42	Yes	Yes	5	4	6
658	S:S:A448	S:S:L399	1.58	No	No	0	8	8
659	S:S:I452	S:S:L399	4.28	No	No	0	6	8
660	S:S:L404	S:S:V400	2.98	No	No	0	4	3
661	S:S:G402	S:S:I401	1.76	No	Yes	5	9	4
662	S:S:F405	S:S:I401	6.28	Yes	Yes	0	8	4
663	S:S:I406	S:S:S441	4.64	No	No	0	8	8
664	S:S:A408	S:S:G409	1.95	No	No	0	5	9
665	S:S:F414	S:S:L410	17.05	No	No	0	5	7
666	S:S:A412	S:S:K415	1.61	No	No	0	7	7
667	S:S:L413	S:S:M434	2.83	No	No	1	8	8
668	S:S:I416	S:S:L420	2.85	No	No	0	8	6
669	S:S:Q421	S:S:R417	5.84	No	No	0	6	8
670	S:S:L430	S:S:R417	3.64	No	No	0	8	8
671	S:S:E431	S:S:L430	2.65	No	No	0	8	8
672	S:S:E431	S:S:R432	4.65	No	No	0	8	7
673	S:S:K436	S:S:R432	2.48	No	No	1	9	7
674	S:S:R432	S:S:W494	4	No	Yes	1	7	9
675	S:S:I437	S:S:L433	7.14	Yes	No	1	8	8
676	S:S:L433	S:S:W494	17.08	No	Yes	1	8	9
677	S:S:K436	S:S:W494	38.29	No	Yes	1	9	9
678	S:S:I437	S:S:W494	5.87	Yes	Yes	1	8	9
679	S:S:F440	S:S:M493	8.71	No	No	0	9	6
680	S:S:V487	S:S:Y444	5.05	Yes	No	0	8	8
681	S:S:P447	S:S:V446	3.53	No	No	0	8	6
682	S:S:I450	S:S:V446	3.07	Yes	No	0	4	6
683	S:S:M483	S:S:P447	1.68	Yes	No	0	9	8
684	S:S:P447	S:S:V487	1.77	No	Yes	0	8	8
685	S:S:I450	S:S:L479	2.85	Yes	No	14	4	6
686	S:S:I450	S:S:M483	7.29	Yes	Yes	14	4	9
687	S:S:F456	S:S:I452	3.77	No	No	0	4	6
688	S:S:C454	S:S:L479	1.59	No	No	0	6	6
689	S:S:C454	S:S:K480	4.85	No	Yes	0	6	8
690	S:S:E458	S:S:Y455	2.24	Yes	Yes	3	9	4
691	S:S:K480	S:S:Y455	8.36	Yes	Yes	3	8	4
692	S:S:N461	S:S:Y457	4.65	No	No	0	5	8
693	S:S:S472	S:S:Y457	5.09	No	No	0	8	8
694	S:S:V476	S:S:Y457	2.52	No	No	0	6	8
695	S:S:E458	S:S:F465	17.49	Yes	No	3	9	8
696	S:S:E458	S:S:R466	3.49	Yes	Yes	3	9	4
697	S:S:E458	S:S:K480	5.4	Yes	Yes	3	9	8
698	S:S:N461	S:S:S460	2.98	No	No	0	5	3
699	S:S:R466	S:S:W462	25.99	Yes	No	0	4	7
700	S:S:L464	S:S:S468	3	No	No	0	1	4
701	S:S:F465	S:S:R466	7.48	No	Yes	3	8	4
702	S:S:F465	S:S:N473	10.87	No	Yes	0	8	5
703	S:S:D470	S:S:N473	5.39	No	Yes	0	2	5
704	S:S:N473	S:S:S472	2.98	Yes	No	0	5	8
705	S:S:N473	S:S:V476	2.96	Yes	No	0	5	6
706	S:S:M474	S:S:M478	2.89	Yes	No	0	4	6
707	S:S:E477	S:S:K480	8.1	No	Yes	0	6	8
708	S:S:L479	S:S:M483	2.83	No	Yes	14	6	9
709	S:S:F482	S:S:M483	3.73	No	Yes	14	7	9
710	S:S:F482	S:S:L486	6.09	No	No	14	7	5
711	S:S:L486	S:S:M483	2.83	No	Yes	14	5	9
712	S:S:G488	S:S:V487	1.84	Yes	Yes	0	9	8
713	S:S:G488	S:S:S491	1.86	Yes	Yes	1	9	8
714	S:S:G492	S:S:I495	3.53	No	Yes	1	7	7
715	S:S:G492	S:S:W496	7.04	No	No	1	7	6
716	S:S:I495	S:S:W496	2.35	Yes	No	1	7	6
717	S:S:A498	S:S:S497	1.71	No	No	0	4	9
718	S:S:K499	S:S:S497	3.06	No	No	0	9	9
719	S:S:S497	S:S:T500	1.6	No	No	0	9	8
720	S:S:T500	S:S:W504	2.43	No	Yes	0	8	9
721	S:S:L501	S:S:Q505	3.99	No	No	0	3	5
722	S:S:H502	S:S:Q505	4.95	No	No	0	4	5
723	S:S:K506	S:S:T503	4.5	No	No	0	3	7
724	S:S:F507	S:S:W504	3.01	Yes	Yes	0	5	9
725	S:S:K506	S:S:R510	3.71	No	No	0	3	7
726	S:S:F507	S:S:R510	5.34	Yes	No	0	5	7
727	S:S:F507	S:S:L511	6.09	Yes	No	0	5	3
728	S:S:N509	S:S:Y508	6.98	No	No	0	3	3
729	S:S:V512	S:S:Y508	6.31	No	No	0	2	3
730	S:S:N513	S:S:V512	4.43	No	No	0	3	2
731	E:E:E434	E:E:P433	1.57	No	No	0	0	0
732	E:E:E471	E:E:P470	1.57	No	No	0	0	0
733	S:S:E289	S:S:P290	1.57	Yes	Yes	6	3	3
734	R:R:I192	R:R:V291	1.54	No	No	0	4	4
735	R:R:I221	R:R:V225	1.54	No	No	0	1	4
736	R:R:I459	R:R:V392	1.54	No	Yes	0	6	6
737	S:S:I221	S:S:V225	1.54	No	No	0	1	4
738	S:S:I406	S:S:V442	1.54	No	No	0	8	5
739	S:S:I452	S:S:V451	1.54	No	No	0	6	7
740	S:S:M260	S:S:S259	1.53	No	Yes	0	4	8
741	E:E:I449	E:E:T491	1.52	Yes	No	0	0	0
742	R:R:M260	R:R:V238	1.52	No	No	0	4	6
743	R:R:I243	R:R:T503	1.52	No	No	0	6	7
744	R:R:M365	R:R:V361	1.52	No	No	0	5	4
745	R:R:I401	R:R:T397	1.52	No	No	0	4	4
746	S:S:I270	S:S:T274	1.52	No	No	0	5	3
747	S:S:M365	S:S:V361	1.52	No	No	0	5	4
748	S:S:M493	S:S:V439	1.52	No	No	0	6	5
749	S:S:I450	S:S:T449	1.52	Yes	No	0	4	5
750	E:E:F505	E:E:G506	1.51	Yes	No	0	0	0
751	R:R:M474	R:R:T219	1.51	No	No	0	4	5
752	S:S:F328	S:S:G409	1.51	No	No	0	7	9
753	E:E:K494	E:E:T496	1.5	No	No	0	0	0
754	R:R:L229	R:R:S228	1.5	No	No	0	5	4
755	E:E:L437	E:E:V439	1.49	Yes	No	0	0	0
756	R:R:L229	R:R:V225	1.49	No	No	0	5	4
757	R:R:L404	R:R:V400	1.49	No	No	0	4	3
758	R:R:N473	R:R:S468	1.49	No	No	0	5	4
759	S:S:L229	S:S:V225	1.49	No	No	0	5	4
760	S:S:L242	S:S:V238	1.49	No	No	0	5	6
761	S:S:N419	S:S:S418	1.49	No	No	0	5	5
762	R:R:N509	R:R:V512	1.48	No	No	0	3	2
763	E:E:I447	E:E:I449	1.47	No	Yes	0	0	0
764	R:R:L307	R:R:T359	1.47	No	No	0	7	8
765	R:R:L363	R:R:T359	1.47	No	No	0	8	8
766	R:R:L399	R:R:T445	1.47	No	No	0	8	7
767	R:R:L399	R:R:T449	1.47	No	No	0	8	5
768	R:R:L486	R:R:T490	1.47	No	No	0	5	7
769	S:S:I255	S:S:I256	1.47	No	Yes	0	8	7
770	S:S:L307	S:S:T359	1.47	No	No	0	7	8
771	S:S:I360	S:S:I364	1.47	No	No	0	7	7
772	S:S:I416	S:S:K415	1.45	No	No	0	8	7
773	S:S:E217	S:S:S214	1.44	No	No	0	3	3
774	S:S:E341	S:S:S249	1.44	No	No	0	7	6
775	E:E:E467	E:E:V419	1.43	No	No	0	0	0
776	R:R:I489	R:R:L229	1.43	No	No	0	8	5
777	R:R:I481	R:R:L485	1.43	No	No	0	7	8
778	S:S:E289	S:S:V194	1.43	Yes	No	0	3	5
779	S:S:I459	S:S:L384	1.43	No	No	0	6	2
780	S:S:I459	S:S:L387	1.43	No	No	0	6	8
781	E:E:A475	E:E:F469	1.39	No	Yes	0	0	0
782	R:R:A356	R:R:F311	1.39	No	Yes	0	8	9
783	R:R:H348	R:R:S344	1.39	Yes	No	0	9	8
784	S:S:A356	S:S:F311	1.39	No	Yes	0	8	9
785	R:R:L367	R:R:N383	1.37	No	Yes	0	6	6
786	S:S:D470	S:S:L464	1.36	No	No	0	2	1
787	S:S:D385	S:S:N383	1.35	No	No	0	2	6
788	R:R:D470	R:R:D471	1.33	No	No	0	2	1
789	E:E:F497	E:E:S480	1.32	Yes	No	0	0	0
790	R:R:R247	R:R:S246	1.32	No	No	0	9	4
791	S:S:R213	S:S:S212	1.32	No	No	0	1	4
792	E:E:F497	E:E:V459	1.31	Yes	Yes	2	0	0
793	R:R:D189	R:R:Q190	1.31	No	No	0	4	3
794	S:S:H502	S:S:K506	1.31	No	No	0	4	3
795	E:E:D457	E:E:E438	1.3	No	No	0	0	0
796	R:R:H502	R:R:L501	1.29	Yes	No	0	4	3
797	R:R:F396	R:R:I452	1.26	No	No	0	2	6
798	R:R:S233	R:R:W496	1.24	No	No	0	8	6
799	R:R:E341	R:R:H337	1.23	No	No	0	7	6
800	R:R:L297	R:R:R366	1.21	No	No	0	6	6
801	S:S:L297	S:S:R366	1.21	Yes	No	0	6	6
802	S:S:T490	S:S:W496	1.21	No	No	0	7	6
803	S:S:D207	S:S:Y206	1.15	No	No	0	4	4
804	R:R:R466	R:R:Y467	1.03	Yes	No	0	4	1
805	S:S:F507	S:S:Y508	1.03	Yes	No	0	5	3
806	S:S:Y191	S:S:Y467	0.99	No	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:S435	3.68	4	17	0
2	E:E:L437	2.785	4	0	0
3	E:E:W444	3.3725	4	2	0
4	E:E:I449	2.894	5	0	0
5	E:E:F453	6.7075	4	2	0
6	E:E:V458	3.072	5	2	0
7	E:E:V459	3.9775	4	2	0
8	E:E:W461	8.2675	4	17	0
9	E:E:F469	4.595	4	18	0
10	E:E:Y478	11.672	5	2	0
11	E:E:L482	13.6225	4	2	0
12	E:E:L487	9.545	4	2	0
13	E:E:I488	5.39167	6	2	0
14	E:E:H490	6.4475	4	2	0
15	E:E:V492	3.99	5	2	0
16	E:E:F497	6.844	5	2	0
17	E:E:C501	3.105	4	2	0
18	E:E:Y502	4.302	5	0	0
19	E:E:Y503	6.535	6	2	0
20	E:E:F505	5.645	6	2	0
21	R:R:V194	4.598	5	10	5
22	R:R:V201	4.5975	4	10	6
23	R:R:C204	3.5125	4	19	8
24	R:R:Y206	5.44667	6	7	4
25	R:R:W222	12.4975	4	20	8
26	R:R:C230	2.724	5	0	7
27	R:R:F231	4.818	5	21	4
28	R:R:T234	2.72	4	0	8
29	R:R:T237	4.74	4	8	8
30	R:R:T240	4.936	5	8	9
31	R:R:Y250	5.7525	4	22	9
32	R:R:Y262	6.02	4	4	8
33	R:R:R272	5.24	5	7	8
34	R:R:V275	2.9875	4	0	4
35	R:R:R277	8.164	5	7	6
36	R:R:Q294	6.9175	4	10	6
37	R:R:F306	6.376	5	0	9
38	R:R:L309	4.43	4	23	6
39	R:R:Y310	4.805	6	9	9
40	R:R:F311	3.6975	4	0	9
41	R:R:F312	8.905	4	0	8
42	R:R:M314	2.745	4	0	8
43	R:R:I318	4.1125	4	25	5
44	R:R:W319	8.486	5	15	9
45	R:R:W320	7.055	6	4	9
46	R:R:L323	5.3475	4	0	9
47	R:R:T324	4.9725	4	4	8
48	R:R:W327	4.27	6	4	9
49	R:R:K334	3.4875	4	2	8
50	R:R:H348	4.69	4	15	9
51	R:R:W352	4.362	5	15	9
52	R:R:I354	3.875	4	25	4
53	R:R:P355	2.835	4	25	9
54	R:R:V379	3.028	5	9	8
55	R:R:N383	2.95	4	9	6
56	R:R:V392	2.2075	4	11	6
57	R:R:Y398	5.74	4	0	6
58	R:R:F405	3.26	4	0	8
59	R:R:I437	2.7675	4	4	8
60	R:R:F440	4.542	5	4	9
61	R:R:Y444	6.8275	4	4	8
62	R:R:V446	2.4475	4	0	6
63	R:R:Y455	7.255	4	11	4
64	R:R:F465	11.334	5	16	8
65	R:R:R466	5.41	4	0	4
66	R:R:V476	4.0725	4	16	6
67	R:R:W494	6.65	5	4	9
68	R:R:I495	3.74333	6	8	7
69	R:R:T500	3.64	4	8	8
70	R:R:H502	3.255	4	0	4
71	R:R:W504	5.492	5	8	9
72	S:S:C204	5.0725	4	6	8
73	S:S:G205	3.015	4	6	3
74	S:S:M223	4.22	4	0	6
75	S:S:W226	9.9275	4	0	5
76	S:S:C230	2.428	5	1	7
77	S:S:F231	5.0575	4	0	4
78	S:S:T234	4.27	4	1	8
79	S:S:T237	4.735	4	1	8
80	S:S:R247	5.975	4	0	9
81	S:S:Y250	6.674	5	13	9
82	S:S:I256	5.225	4	1	7
83	S:S:S259	3.508	5	1	8
84	S:S:Y265	4.9725	4	0	7
85	S:S:Y269	4.5775	4	0	6
86	S:S:R272	7.1625	4	0	8
87	S:S:V275	3.76	4	0	4
88	S:S:R277	7.854	5	6	6
89	S:S:S281	3.635	4	6	7
90	S:S:C282	4.1125	4	6	9
91	S:S:E289	8.578	5	6	3
92	S:S:P290	5.9675	4	6	3
93	S:S:L297	2.1625	4	0	6
94	S:S:F306	4.914	5	3	9
95	S:S:Y310	3.68833	6	3	9
96	S:S:F311	5.475	4	0	9
97	S:S:M314	4.625	4	5	8
98	S:S:I318	3.098	5	5	5
99	S:S:W319	6.32167	6	12	9
100	S:S:W320	8.492	5	5	9
101	S:S:T324	2.992	5	5	8
102	S:S:W327	4.75	4	1	9
103	S:S:A331	2.72	4	1	8
104	S:S:W352	5.034	5	12	9
105	S:S:I354	3.4475	4	5	4
106	S:S:P355	4.3925	4	5	9
107	S:S:I362	7.14	4	3	6
108	S:S:L373	5.39	4	26	8
109	S:S:T374	3.7575	4	0	8
110	S:S:V379	3.51333	6	3	8
111	S:S:V391	3.554	5	3	7
112	S:S:Y398	3.94	6	5	6
113	S:S:I401	3.7675	4	5	4
114	S:S:F405	4.5275	4	0	8
115	S:S:I437	5.73	4	1	8
116	S:S:I450	3.6825	4	14	4
117	S:S:Y455	4.102	5	3	4
118	S:S:E458	7.155	4	3	9
119	S:S:R466	11.285	4	3	4
120	S:S:N473	5.55	4	0	5
121	S:S:M474	3.485	4	26	4
122	S:S:K480	6.6775	4	3	8
123	S:S:M483	3.672	5	14	9
124	S:S:V487	4.0575	4	0	8
125	S:S:G488	2.36	4	1	9
126	S:S:S491	3.2875	4	1	8
127	S:S:W494	16.538	5	1	9
128	S:S:I495	4.3775	4	1	7
129	S:S:W504	4.60667	6	1	9
130	S:S:F507	3.8675	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C501	R:R:K334	10.5065	1.62	Yes	Yes	2	0	8
2	E:E:C501	E:E:Y503	23.6149	2.69	Yes	Yes	2	0	0
3	E:E:Q500	E:E:S498	35.6795	2.89	No	No	0	0	0
4	E:E:C501	E:E:S498	35.4222	5.16	Yes	No	0	0	0
5	E:E:Q500	R:R:A339	35.9364	3.03	No	No	0	0	8
6	R:R:A339	R:R:W335	36.193	5.19	No	No	0	8	8
7	R:R:L333	R:R:W335	36.7051	5.69	No	No	0	6	8
8	R:R:F328	R:R:L333	36.9607	3.65	No	No	0	7	6
9	R:R:F328	R:R:F405	37.2159	4.29	No	Yes	0	7	8
10	R:R:F405	R:R:T324	37.6586	2.59	Yes	Yes	0	8	8
11	R:R:T324	R:R:W320	37.8511	7.28	Yes	Yes	4	8	9
12	R:R:W320	R:R:Y444	41.4383	20.26	Yes	Yes	4	9	8
13	R:R:Y262	R:R:Y444	36.6165	1.99	Yes	Yes	4	8	8
14	R:R:C230	R:R:S266	13.3902	5.16	Yes	No	0	7	8
15	R:R:A227	R:R:S266	14.5458	1.71	No	No	0	7	8
16	R:R:A227	R:R:Y269	14.732	2.67	No	No	0	7	6
17	R:R:M223	R:R:Y269	23.4276	4.79	No	No	0	6	6
18	R:R:M223	R:R:R272	23.1806	8.69	No	Yes	0	6	8
19	R:R:R272	R:R:R277	10.8102	4.26	Yes	Yes	7	8	6
20	R:R:L376	R:R:R272	10.6977	2.43	No	Yes	0	7	8
21	R:R:L376	R:R:T374	10.4393	4.42	No	No	0	7	8
22	R:R:P447	R:R:V487	15.5307	3.53	No	No	0	8	8
23	R:R:C454	R:R:K480	11.8278	3.23	No	No	0	6	8
24	R:R:K480	R:R:Y455	11.0466	19.11	No	Yes	0	8	4
25	R:R:S259	R:R:T234	10.0117	1.6	No	Yes	0	8	8
26	R:R:S316	R:R:Y262	43.2431	10.17	No	Yes	0	8	8
27	R:R:C261	R:R:S316	43.5273	1.72	No	No	0	8	8
28	R:R:C261	R:R:F312	43.6988	5.59	No	Yes	0	8	8
29	R:R:Y265	R:R:Y269	33.1569	9.93	No	No	0	7	6
30	R:R:F312	R:R:L308	51.9263	2.44	Yes	No	0	8	5
31	R:R:A268	R:R:L308	52.2691	3.15	No	No	0	6	5
32	R:R:A268	R:R:I305	52.1927	1.62	No	No	23	6	7
33	R:R:I305	R:R:V271	90.5569	3.07	No	No	0	7	4
34	R:R:V271	R:R:V275	90.6861	1.6	No	Yes	0	4	4
35	R:R:R279	R:R:V275	45.481	2.62	No	Yes	0	3	4
36	R:R:I280	R:R:V275	45.505	6.14	No	Yes	0	6	4
37	R:R:N299	R:R:R279	45.5397	8.44	No	No	0	7	3
38	R:R:G301	R:R:I280	54.4885	1.76	No	No	0	4	6
39	R:R:N299	R:R:T300	45.5668	2.92	No	No	24	7	5
40	R:R:G301	R:R:T300	54.4957	3.64	No	No	24	4	5
41	R:R:T300	S:S:A303	100	1.68	No	No	0	5	8
42	S:S:A303	S:S:L297	99.937	1.58	No	Yes	0	8	6
43	S:S:G296	S:S:L297	99.746	1.71	No	Yes	0	6	6
44	S:S:G296	S:S:V368	99.6816	3.68	No	No	0	6	8
45	S:S:F306	S:S:V368	82.8891	7.87	Yes	No	0	9	8
46	S:S:F306	S:S:V379	37.9204	3.93	Yes	Yes	3	9	8
47	S:S:V379	S:S:V391	37.3058	1.6	Yes	Yes	3	8	7
48	S:S:V391	S:S:Y455	35.334	5.05	Yes	Yes	3	7	4
49	S:S:E289	S:S:P290	17.2689	1.57	Yes	Yes	6	3	3
50	S:S:K480	S:S:Y455	26.8489	8.36	Yes	Yes	3	8	4
51	S:S:E477	S:S:K480	11.5029	8.1	No	Yes	0	6	8
52	S:S:E477	S:S:L373	11.3074	2.65	No	Yes	0	6	8
53	S:S:L373	S:S:T219	21.3718	2.95	Yes	No	0	8	5
54	S:S:D220	S:S:T219	21.0014	2.89	No	No	0	6	5
55	S:S:D220	S:S:R272	20.1006	9.53	No	Yes	0	6	8
56	S:S:R272	S:S:R277	20.3729	11.73	Yes	Yes	0	8	6
57	S:S:C377	S:S:V368	18.1967	1.71	No	No	0	9	8
58	S:S:A370	S:S:C377	16.437	1.81	No	No	0	8	9
59	S:S:A370	S:S:L292	15.996	1.58	No	No	0	8	5
60	S:S:E372	S:S:L292	15.8619	2.65	No	No	0	6	5
61	S:S:E372	S:S:L210	15.7425	3.98	No	No	0	6	4
62	S:S:L210	S:S:Y211	15.6685	2.34	No	No	0	4	7
63	S:S:L373	S:S:Y211	10.5905	11.72	Yes	No	26	8	7
64	S:S:G205	S:S:R277	12.0085	4.5	Yes	Yes	6	3	6
65	S:S:C454	S:S:K480	15.7967	4.85	No	Yes	0	6	8
66	S:S:C454	S:S:L479	15.6208	1.59	No	No	0	6	6
67	S:S:L479	S:S:M483	14.9054	2.83	No	Yes	14	6	9
68	S:S:F306	S:S:Y310	43.3588	5.16	Yes	Yes	3	9	9
69	S:S:K358	S:S:Y310	43.4987	3.58	No	Yes	0	7	9
70	S:S:K358	S:S:M314	37.5417	2.88	No	Yes	0	7	8
71	S:S:M314	S:S:Y398	32.1604	5.99	Yes	Yes	5	8	6
72	S:S:V321	S:S:Y398	18.1836	3.79	No	Yes	5	9	6
73	S:S:T324	S:S:V321	18.0327	1.59	Yes	No	5	8	9
74	S:S:T324	S:S:W320	10.9472	6.06	Yes	Yes	5	8	9
75	S:S:W320	S:S:Y444	21.6136	26.04	Yes	No	0	9	8
76	S:S:V487	S:S:Y444	21.2977	5.05	Yes	No	0	8	8
77	S:S:G488	S:S:V487	30.9988	1.84	Yes	Yes	0	9	8
78	S:S:I401	S:S:Y398	13.6286	2.42	Yes	Yes	5	4	6
79	S:S:G402	S:S:I401	10.7685	1.76	No	Yes	5	9	4
80	S:S:G402	S:S:W320	10.6112	4.22	No	Yes	5	9	9
81	S:S:M483	S:S:P447	10.8676	1.68	Yes	No	0	9	8
82	S:S:P447	S:S:V487	10.7863	1.77	No	Yes	0	8	8
83	S:S:G488	S:S:S491	25.311	1.86	Yes	Yes	1	9	8
84	S:S:S491	S:S:T237	17.5165	1.6	Yes	Yes	1	8	8
85	S:S:I495	S:S:T237	15.3532	9.12	Yes	Yes	1	7	8
86	S:S:F236	S:S:I495	13.5846	2.51	No	Yes	1	5	7
87	S:S:F236	S:S:W504	12.3976	2	No	Yes	1	5	9
88	R:R:L309	R:R:Y265	33.4883	7.03	Yes	No	0	6	7
89	R:R:V487	R:R:Y262	11.4183	7.57	No	Yes	4	8	8
90	R:R:I305	R:R:L309	38.2356	2.85	No	Yes	23	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8WM9_poly

PDB Summary
PDB	8WM9_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.58
Number of Linked Nodes	661
Number of Links	806
Number of Hubs	130
Number of Links mediated by Hubs	457
Number of Communities	26
Number of Nodes involved in Communities	190
Number of Links involved in Communities	265

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	805424
Length Of Smallest Path	3
Average Path Length	30.2123
Length of Longest Path	60
Minimum Path Strength	1.315
Average Path Strength	4.46709
Maximum Path Strength	27.87
Minimum Path Correlation	0.7
Average Path Correlation	0.978071
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.27273
Average % Of Corr. Nodes	44.571
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.7955
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • Wnt receptor activity • amide binding • amyloid-beta binding • binding • peptide binding • protein-containing complex binding • ubiquitin protein ligase binding • protein binding • ubiquitin-like protein ligase binding • enzyme binding • Wnt-protein binding • G protein-coupled receptor activity • PDZ domain binding • protein domain specific binding • protein heterodimerization activity • protein dimerization activity • cytokine receptor activity • immune receptor activity • cytokine binding • identical protein binding • protein homodimerization activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • canonical Wnt signaling pathway • biological regulation • cell communication • cellular process • signal transduction • Wnt signaling pathway • cell population proliferation • cell adhesion
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • canonical Wnt signaling pathway • biological regulation • cell communication • cellular process • signal transduction • Wnt signaling pathway • cell population proliferation • cell adhesion • substrate adhesion-dependent cell spreading • cell-substrate adhesion • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • response to retinoic acid • cellular response to chemical stimulus • cellular response to retinoic acid • response to chemical • cellular response to lipid • multicellular organismal process • system process • sensory perception • nervous system process • sensory perception of sound • sensory perception of mechanical stimulus • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • regulation of cellular component organization • positive regulation of cellular component organization • regulation of developmental process • cellular developmental process • regulation of neuron projection arborization • cell projection organization • plasma membrane bounded cell projection morphogenesis • positive regulation of biological process • cell development • neuron projection development • cell morphogenesis • regulation of cell morphogenesis • cellular component organization • positive regulation of developmental process • neurogenesis • multicellular organism development • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cell differentiation • anatomical structure development • positive regulation of cell projection organization • cellular component organization or biogenesis • regulation of anatomical structure morphogenesis • positive regulation of cellular process • system development • developmental process • plasma membrane bounded cell projection organization • regulation of cell projection organization • positive regulation of neuron projection arborization • nervous system development • generation of neurons • anatomical structure morphogenesis • neuron projection arborization • neuron development • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • sensory organ development • blood vessel morphogenesis • tube development • retina vasculature development in camera-type eye • eye development • animal organ development • retina development in camera-type eye • visual system development • retina vasculature morphogenesis in camera-type eye • vasculature development • circulatory system development • tube morphogenesis • camera-type eye development • retinal blood vessel morphogenesis • sensory system development • blood vessel development • establishment of blood-brain barrier • central nervous system development • angiogenesis • anatomical structure formation involved in morphogenesis • head development • cerebellum vasculature development • brain development • cerebellum development • metencephalon development • cerebellum vasculature morphogenesis • hindbrain development • non-canonical Wnt signaling pathway • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • Norrin signaling pathway • cellular process involved in reproduction in multicellular organism • localization • development of primary sexual characteristics • reproductive structure development • regulation of biological quality • gonad development • luteinization • regulation of hormone levels • lipid transport • establishment of localization • endocrine hormone secretion • lipid export from cell • ovulation cycle process • transport • reproductive process • steroid hormone secretion • sex differentiation • development of primary female sexual characteristics • hormone secretion • developmental process involved in reproduction • progesterone secretion • ovulation cycle • secretion by cell • signal release • rhythmic process • reproductive system development • secretion • female gonad development • multicellular organismal reproductive process • lipid localization • export from cell • cell-cell signaling • female sex differentiation • endocrine process • macromolecule localization • hormone transport • cellular response to growth factor stimulus • regulation of signal transduction • cell surface receptor protein tyrosine kinase signaling pathway • regulation of vascular endothelial growth factor receptor signaling pathway • cellular response to endogenous stimulus • enzyme-linked receptor protein signaling pathway • regulation of signaling • response to endogenous stimulus • regulation of cellular response to growth factor stimulus • vascular endothelial growth factor receptor signaling pathway • regulation of response to stimulus • regulation of cell communication • response to growth factor • vasculogenesis • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • extracellular matrix-cell signaling • regulation of cell-substrate adhesion • regulation of cell adhesion • negative regulation of biological process • negative regulation of cell adhesion • negative regulation of cellular process • negative regulation of cell-substrate adhesion • Wnt signaling pathway, calcium modulating pathway • behavior • locomotory behavior • locomotion involved in locomotory behavior • positive regulation of nervous system development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of dendrite morphogenesis • positive regulation of cell development • positive regulation of cell morphogenesis • regulation of dendrite development • positive regulation of multicellular organismal process • regulation of neuron projection development • regulation of nervous system development • positive regulation of cell differentiation • dendrite development • positive regulation of neurogenesis • regulation of multicellular organismal process • regulation of multicellular organismal development • positive regulation of dendrite morphogenesis • dendrite morphogenesis • cell morphogenesis involved in neuron differentiation • regulation of plasma membrane bounded cell projection organization • response to peptide • response to cytokine • response to leukemia inhibitory factor • cellular response to cytokine stimulus • cellular response to leukemia inhibitory factor • cell-cell junction • cellular anatomical structure • anchoring junction • cell junction • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle
Gene Ontology	Cellular Component	• cell-cell junction • cellular anatomical structure • anchoring junction • cell junction • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • glutamatergic synapse • cilium • cell surface • cell periphery • plasma membrane • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • small GTPase binding • protein binding • binding • enzyme binding • GTPase binding • protein domain specific binding • signaling receptor binding • G protein-coupled receptor binding • frizzled binding • protein-macromolecule adaptor activity • molecular adaptor activity • kinase binding • protein kinase binding • identical protein binding • developmental process • multicellular organism development • multicellular organismal process • segmentation • anatomical structure development • pattern specification process • regionalization • segment specification • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of signal transduction by p53 class mediator • positive regulation of signal transduction by p53 class mediator • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • signal transduction by p53 class mediator • regulation of response to stimulus • regulation of cell communication • cellular process • positive regulation of signaling • heart development • animal organ development • circulatory system development • system development • localization • macromolecule localization • intracellular protein localization • cell surface receptor signaling pathway • canonical Wnt signaling pathway • Wnt signaling pathway • non-canonical Wnt signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • actin cytoskeleton organization • regulation of organelle organization • cellular component organization • organelle organization • regulation of actin cytoskeleton organization • actin filament-based process • cellular component organization or biogenesis • cytoskeleton organization • embryonic epithelial tube formation • chordate embryonic development • tube formation • embryo development • epithelial tube formation • tube morphogenesis • primary neural tube formation • embryo development ending in birth or egg hatching • epithelial tube morphogenesis • morphogenesis of embryonic epithelium • epithelium development • neural tube development • tube development • embryonic morphogenesis • morphogenesis of an epithelium • nervous system development • tissue development • anatomical structure morphogenesis • tissue morphogenesis • neural tube closure • neural tube formation • anatomical structure formation involved in morphogenesis • tube closure • positive regulation of JNK cascade • JNK cascade • intracellular signaling cassette • positive regulation of MAPK cascade • regulation of JNK cascade • regulation of MAPK cascade • MAPK cascade • Wnt signaling pathway, planar cell polarity pathway • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • ear morphogenesis • embryonic organ morphogenesis • ear development • sensory organ development • sensory organ morphogenesis • inner ear development • cochlea development • inner ear morphogenesis • cochlea morphogenesis • animal organ morphogenesis • embryonic organ development • neural plate development • convergent extension involved in gastrulation • convergent extension involved in organogenesis • morphogenesis of an epithelial sheet • gastrulation • convergent extension involved in neural plate elongation • neural plate elongation • convergent extension • neural plate morphogenesis • cell population proliferation • regulation of cell population proliferation • positive regulation of cellular component organization • regulation of developmental process • cellular developmental process • regulation of neuron projection arborization • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • regulation of cell morphogenesis • positive regulation of developmental process • neurogenesis • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cell differentiation • positive regulation of cell projection organization • regulation of anatomical structure morphogenesis • plasma membrane bounded cell projection organization • regulation of cell projection organization • positive regulation of neuron projection arborization • generation of neurons • neuron projection arborization • neuron development • positive regulation of DNA-templated transcription • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • heart morphogenesis • embryonic heart tube development • embryonic heart tube morphogenesis • heart looping • determination of bilateral symmetry • determination of left/right symmetry • specification of symmetry • determination of heart left/right asymmetry • left/right pattern formation • outflow tract morphogenesis • apical part of cell • cytosol • inclusion body • aggresome • lateral plasma membrane • intracellular membraneless organelle • nuclear body • membraneless organelle
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Winged helix DNA-binding domain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Winged helix DNA-binding domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9ULV1
Sequence	>8WM9_poly_Chain_R S D Q Y I W V K R S L N C V L K C G Y D A G L Y S R S A K E F T D I W M A V W A S L C F I S T A F T V L T F L I D S S R F S Y P E R P I I F L S M C Y N I Y S I A Y I V R L T V G R E R I S C E P V L I Q E G L K N T G C A I I F L L L Y F F G M A S S I W W V I L T L T W F L A A G L K W G H E A I E M H S S Y F H I A A W A I P A V K T I V I L I M R L V D A D E L T G L C Y V G N Q N L D A L T G F V V A P L F T Y L V I G T L F I A A G L V A L F K I R S N L Q K D G T K T D K L E R L M V K I G V F S V L Y T V P A T I V I A C Y F Y E I S N W A L F R Y S A D D S N M A V E M L K I F M S L L V G I T S G M W I W S A K T L H T W Q K F Y N R L V N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	Q9ULV1
Sequence	>8WM9_poly_Chain_S S D Q Y I W V K R S L N C G Y D A G L Y S R S A K E F T D I W M A V W A S L C F I S T A F T V L T F L I D S S R F S Y P E R P I I F L S M C Y N I Y S I A Y I V R L T V G R E R I S C D F E P V L I Q E G L K N T G C A I I F L L L Y F F G M A S S I W W V I L T L T W F L A A G L K W G H E A I E M H S S Y F H I A A W A I P A V K T I V I L I M R L V D A D E L T G L C Y V G N Q N L D A L T G F V V A P L F T Y L V I G T L F I A A G L V A L F K I R S N L Q L E R L M V K I G V F S V L Y T V P A T I V I A C Y F Y E I S N W A L F R Y S A D D S N M A V E M L K I F M S L L V G I T S G M W I W S A K T L H T W Q K F Y N R L V N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6BD4	F	Protein	Frizzled	FZD₄	Homo sapiens	-	-	-	2.4	2018-08-22	doi.org/10.1038/s41586-018-0447-x
	8WM9	F	Protein	Frizzled	FZD₄	Homo sapiens	-	-	DVL-2	3.53	2024-09-11	doi.org/10.1038/s41467-024-52174-z
	8WMA	F	Protein	Frizzled	FZD₄	Homo sapiens	-	-	DVL-2	3.47	2024-09-11	doi.org/10.1038/s41467-024-52174-z

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