psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G99	L:L:S98	3.71	No	No	0	0	0
2	L:L:G99	L:L:P100	4.06	No	No	0	0	0
3	L:L:T103	R:R:Y29	4.99	No	No	0	0	8
4	L:L:E106	L:L:S109	4.31	No	No	0	0	0
5	L:L:E106	R:R:R30	9.3	No	No	0	0	4
6	L:L:E107	L:L:Y111	13.47	No	No	0	0	0
7	L:L:L108	L:L:Y111	3.52	No	No	0	0	0
8	L:L:S109	R:R:L193	3	No	Yes	0	0	3
9	L:L:S110	L:L:Y111	3.82	No	No	0	0	0
10	L:L:R113	R:R:R32	10.66	No	No	0	0	7
11	L:L:G116	R:R:V35	5.52	No	No	0	0	5
12	L:L:G116	R:R:C200	3.92	No	No	0	0	4
13	L:L:G117	R:R:C200	3.92	No	No	0	0	4
14	L:L:F118	L:L:F120	5.36	Yes	Yes	2	0	0
15	L:L:F118	R:R:Q105	5.86	Yes	Yes	2	0	5
16	L:L:F118	R:R:W111	14.03	Yes	Yes	2	0	8
17	L:L:F120	R:R:V101	5.24	Yes	No	2	0	5
18	L:L:F120	R:R:Q105	14.05	Yes	Yes	2	0	5
19	L:L:F120	R:R:W111	7.02	Yes	Yes	2	0	8
20	L:L:F120	R:R:P122	5.78	Yes	Yes	2	0	5
21	L:L:F120	R:R:Q125	3.51	Yes	Yes	2	0	7
22	L:L:F120	R:R:Q184	8.2	Yes	Yes	2	0	5
23	L:L:F122	L:L:R121	11.76	Yes	Yes	0	0	0
24	L:L:R121	R:R:E203	9.3	Yes	No	0	0	5
25	L:L:R121	R:R:Y214	5.14	Yes	Yes	0	0	6
26	L:L:R121	R:R:H293	10.16	Yes	No	0	0	5
27	L:L:F122	R:R:S126	5.28	Yes	No	0	0	3
28	L:L:F122	R:R:V129	7.87	Yes	No	0	0	7
29	L:L:F122	R:R:F289	4.29	Yes	Yes	0	0	6
30	R:R:E9	R:R:S12	4.31	No	No	0	7	7
31	R:R:Q10	R:R:R13	22.2	No	No	0	7	7
32	R:R:L14	R:R:Q10	6.65	No	No	0	7	7
33	R:R:F11	R:R:F192	3.22	No	No	0	7	3
34	R:R:F11	R:R:L193	4.87	No	Yes	0	7	3
35	R:R:R16	R:R:S12	7.91	No	No	0	7	7
36	R:R:L15	R:R:R22	7.29	No	No	0	7	7
37	R:R:N19	R:R:R16	4.82	No	No	0	8	7
38	R:R:H18	R:R:L20	6.43	No	No	0	8	5
39	R:R:H18	R:R:T21	5.48	No	No	0	8	8
40	R:R:N19	R:R:R22	8.44	No	No	0	8	7
41	R:R:I26	R:R:T21	4.56	No	No	0	7	8
42	R:R:E195	R:R:E23	6.34	No	No	0	4	6
43	R:R:A27	R:R:Y194	4	No	Yes	0	5	1
44	R:R:R30	R:R:Y29	20.58	No	No	0	4	8
45	R:R:L31	R:R:P33	4.93	No	No	0	6	6
46	R:R:L34	R:R:R32	4.86	No	No	0	5	7
47	R:R:P33	R:R:Y194	12.52	No	Yes	0	6	1
48	R:R:L193	R:R:L34	4.15	Yes	No	0	3	5
49	R:R:T37	R:R:V35	4.76	No	No	0	5	5
50	R:R:D306	R:R:Y36	3.45	No	No	0	1	4
51	R:R:P38	R:R:T37	3.5	No	No	0	2	5
52	R:R:D109	R:R:T37	4.34	No	No	0	4	5
53	R:R:K311	R:R:P38	10.04	No	No	0	2	2
54	R:R:E39	R:R:K45	6.75	No	No	0	3	5
55	R:R:K311	R:R:L40	9.87	No	No	0	2	3
56	R:R:L40	R:R:M312	7.07	No	No	0	3	1
57	R:R:A44	R:R:P41	5.61	No	No	0	1	3
58	R:R:L46	R:R:R43	7.29	No	No	0	4	3
59	R:R:A44	R:R:M312	3.22	No	No	0	1	1
60	R:R:A315	R:R:L48	3.15	No	No	0	4	4
61	R:R:I319	R:R:L48	4.28	No	No	0	4	4
62	R:R:I55	R:R:T51	3.04	No	No	0	8	4
63	R:R:G52	R:R:M103	5.24	No	No	0	6	7
64	R:R:I55	R:R:S323	3.1	No	No	0	8	5
65	R:R:I326	R:R:I55	5.89	No	No	0	7	8
66	R:R:F56	R:R:T95	9.08	No	Yes	0	6	7
67	R:R:F56	R:R:F96	4.29	No	No	0	6	5
68	R:R:I326	R:R:L58	7.14	No	No	0	7	5
69	R:R:A59	R:R:T95	5.03	No	Yes	1	8	7
70	R:R:A59	R:R:S325	3.42	No	No	1	8	9
71	R:R:A59	R:R:I326	3.25	No	No	0	8	7
72	R:R:F61	R:R:G62	3.01	No	No	0	5	8
73	R:R:A88	R:R:N63	3.13	No	Yes	0	9	9
74	R:R:D91	R:R:N63	6.73	Yes	Yes	1	9	9
75	R:R:L92	R:R:N63	13.73	No	Yes	0	8	9
76	R:R:N63	R:R:P329	3.26	Yes	No	1	9	9
77	R:R:L65	R:R:V69	2.98	No	Yes	0	7	7
78	R:R:F334	R:R:L65	7.31	Yes	No	0	6	7
79	R:R:A333	R:R:V66	3.39	No	No	0	7	9
80	R:R:F334	R:R:V66	3.93	Yes	No	0	6	9
81	R:R:C85	R:R:F67	4.19	No	No	0	6	7
82	R:R:A88	R:R:F67	4.16	No	No	0	9	7
83	R:R:F67	R:R:L92	4.87	No	No	0	7	8
84	R:R:R72	R:R:Y68	9.26	No	No	0	5	4
85	R:R:M76	R:R:V69	3.04	Yes	Yes	0	7	7
86	R:R:F339	R:R:V69	9.18	Yes	Yes	0	8	7
87	R:R:A346	R:R:V69	5.09	No	Yes	0	6	7
88	R:R:N81	R:R:V70	2.96	No	No	0	8	7
89	R:R:C85	R:R:V70	5.12	No	No	0	6	7
90	R:R:M76	R:R:S73	6.13	Yes	No	4	7	5
91	R:R:N342	R:R:S73	10.43	Yes	No	4	6	5
92	R:R:A75	R:R:N342	4.69	No	Yes	0	6	6
93	R:R:M76	R:R:N81	5.61	Yes	No	0	7	8
94	R:R:M76	R:R:N342	8.41	Yes	Yes	4	7	6
95	R:R:N81	R:R:T78	8.77	No	No	0	8	8
96	R:R:V79	R:R:Y157	12.62	No	Yes	0	6	6
97	R:R:N159	R:R:V79	4.43	No	No	0	1	6
98	R:R:I84	R:R:T80	3.04	No	No	0	8	8
99	R:R:T80	R:R:Y157	6.24	No	Yes	0	8	6
100	R:R:I82	R:R:N159	4.25	No	No	0	6	1
101	R:R:F163	R:R:I82	5.02	No	No	0	3	6
102	R:R:C138	R:R:F83	4.19	No	Yes	3	7	7
103	R:R:F83	R:R:I139	5.02	Yes	No	0	7	8
104	R:R:E142	R:R:F83	15.16	No	Yes	3	8	7
105	R:R:A162	R:R:F83	4.16	No	Yes	0	7	7
106	R:R:F83	R:R:M165	3.73	Yes	No	3	7	6
107	R:R:F83	R:R:L166	8.53	Yes	No	0	7	7
108	R:R:S86	R:R:T135	3.2	No	No	0	9	8
109	R:R:L166	R:R:S86	7.51	No	No	0	7	9
110	R:R:E132	R:R:L87	3.98	Yes	No	0	9	9
111	R:R:L87	R:R:T135	4.42	No	No	0	9	8
112	R:R:L87	R:R:Y332	4.69	No	No	0	9	9
113	R:R:S90	R:R:T131	4.8	No	No	0	8	7
114	R:R:D91	R:R:E132	9.09	Yes	Yes	1	9	9
115	R:R:D91	R:R:S325	4.42	Yes	No	1	9	9
116	R:R:D91	R:R:N328	4.04	Yes	Yes	1	9	9
117	R:R:D91	R:R:P329	3.22	Yes	No	1	9	9
118	R:R:F96	R:R:L92	7.31	No	No	0	5	8
119	R:R:L93	R:R:V124	2.98	No	No	0	7	5
120	R:R:A128	R:R:L93	3.15	No	No	0	8	7
121	R:R:C98	R:R:I94	6.55	No	No	0	7	7
122	R:R:I94	R:R:V129	3.07	No	No	0	7	7
123	R:R:E132	R:R:I94	4.1	Yes	No	0	9	7
124	R:R:I99	R:R:T95	4.56	No	Yes	0	7	7
125	R:R:S325	R:R:T95	3.2	No	Yes	1	9	7
126	R:R:F97	R:R:M120	3.73	No	No	5	5	4
127	R:R:F97	R:R:V121	3.93	No	No	0	5	5
128	R:R:F97	R:R:V124	14.42	No	No	5	5	5
129	R:R:C98	R:R:Q125	7.63	No	Yes	0	7	7
130	R:R:C98	R:R:F322	6.98	No	No	0	7	7
131	R:R:I99	R:R:P100	5.08	No	No	0	7	8
132	R:R:F322	R:R:I99	3.77	No	No	0	7	7
133	R:R:Q105	R:R:V101	5.73	Yes	No	2	5	5
134	R:R:Q125	R:R:V101	4.3	Yes	No	2	7	5
135	R:R:M103	R:R:T102	3.01	No	Yes	0	7	6
136	R:R:N106	R:R:T102	4.39	No	Yes	0	5	6
137	R:R:Q318	R:R:T102	7.09	No	Yes	0	6	6
138	R:R:F322	R:R:T102	7.78	No	Yes	0	7	6
139	R:R:L104	R:R:S108	3	No	No	0	4	5
140	R:R:A315	R:R:N106	4.69	No	No	0	4	5
141	R:R:I107	R:R:S108	3.1	No	No	0	4	5
142	R:R:H198	R:R:N110	7.65	Yes	No	0	1	5
143	R:R:G113	R:R:W111	4.22	No	Yes	0	7	8
144	R:R:C118	R:R:W111	3.92	No	Yes	2	9	8
145	R:R:F116	R:R:I117	8.79	No	No	0	3	6
146	R:R:C118	R:R:Q184	4.58	No	Yes	2	9	5
147	R:R:C118	R:R:C201	7.28	No	No	2	9	9
148	R:R:K119	R:R:W181	12.76	No	No	0	7	4
149	R:R:M120	R:R:V124	3.04	No	No	5	4	5
150	R:R:P122	R:R:V121	3.53	Yes	No	0	5	5
151	R:R:Q125	R:R:V121	5.73	Yes	No	0	7	5
152	R:R:M180	R:R:P122	6.71	Yes	Yes	0	5	5
153	R:R:P122	R:R:Q184	4.74	Yes	Yes	2	5	5
154	R:R:F123	R:R:T127	7.78	No	No	0	6	5
155	R:R:F123	R:R:V174	9.18	No	No	0	6	4
156	R:R:F123	R:R:W181	5.01	No	No	0	6	4
157	R:R:M180	R:R:S126	4.6	Yes	No	0	5	3
158	R:R:A173	R:R:T127	3.36	No	No	0	8	5
159	R:R:V129	R:R:W286	6.13	No	Yes	0	7	8
160	R:R:L134	R:R:V130	2.98	No	Yes	0	6	6
161	R:R:A173	R:R:V130	3.39	No	Yes	0	8	6
162	R:R:V130	R:R:V176	4.81	Yes	No	0	6	5
163	R:R:L222	R:R:V130	4.47	Yes	Yes	0	6	6
164	R:R:T131	R:R:W170	10.92	No	No	0	7	9
165	R:R:A173	R:R:T131	3.36	No	No	0	8	7
166	R:R:E132	R:R:M136	4.06	Yes	Yes	1	9	8
167	R:R:E132	R:R:N324	3.94	Yes	Yes	1	9	9
168	R:R:E132	R:R:N328	9.2	Yes	Yes	1	9	9
169	R:R:I133	R:R:L222	4.28	No	Yes	0	7	6
170	R:R:I133	R:R:P226	3.39	No	No	6	7	9
171	R:R:F282	R:R:I133	10.05	Yes	No	6	9	7
172	R:R:L134	R:R:V169	8.94	No	No	0	6	7
173	R:R:L134	R:R:V172	2.98	No	No	0	6	5
174	R:R:I139	R:R:T135	3.04	No	No	0	8	8
175	R:R:M136	R:R:N324	4.21	Yes	Yes	1	8	9
176	R:R:M136	R:R:N328	5.61	Yes	Yes	1	8	9
177	R:R:M136	R:R:Y332	3.59	Yes	No	1	8	9
178	R:R:P226	R:R:T137	3.5	No	No	0	9	7
179	R:R:T137	R:R:V229	3.17	No	No	0	7	6
180	R:R:C138	R:R:M165	3.24	No	No	3	7	6
181	R:R:I139	R:R:R143	6.26	No	No	0	8	9
182	R:R:A140	R:R:Y234	5.34	No	Yes	0	9	9
183	R:R:L233	R:R:V141	2.98	No	No	0	7	7
184	R:R:E142	R:R:Y157	12.35	No	Yes	0	8	6
185	R:R:E142	R:R:M165	6.77	No	No	3	8	6
186	R:R:R143	R:R:Y234	9.26	No	Yes	0	9	9
187	R:R:H144	R:R:V148	9.69	Yes	No	0	7	7
188	R:R:H144	R:R:L233	12.86	Yes	No	0	7	7
189	R:R:H144	R:R:K236	14.41	Yes	No	0	7	4
190	R:R:H144	R:R:I237	7.95	Yes	Yes	0	7	9
191	R:R:H149	R:R:Q145	6.18	Yes	No	0	6	5
192	R:R:M153	R:R:Q145	4.08	Yes	No	0	6	5
193	R:R:G146	R:R:M153	3.49	No	Yes	0	8	6
194	R:R:I237	R:R:L147	4.28	Yes	No	0	9	8
195	R:R:H149	R:R:V148	8.3	Yes	No	0	6	7
196	R:R:H149	R:R:K152	14.41	Yes	No	0	6	4
197	R:R:K152	R:R:M153	4.32	No	Yes	7	4	6
198	R:R:K152	R:R:Q156	10.85	No	Yes	7	4	4
199	R:R:M153	R:R:Q156	5.44	Yes	Yes	7	6	4
200	R:R:M153	R:R:Y157	3.59	Yes	Yes	0	6	6
201	R:R:Q156	R:R:W155	14.24	Yes	No	0	4	4
202	R:R:Q156	R:R:R161	7.01	Yes	No	0	4	5
203	R:R:I175	R:R:L171	4.28	No	No	0	4	5
204	R:R:F217	R:R:V176	3.93	No	No	0	4	5
205	R:R:P179	R:R:Y214	4.17	No	Yes	0	7	6
206	R:R:E203	R:R:M180	4.06	No	Yes	0	5	5
207	R:R:M180	R:R:Y214	4.79	Yes	Yes	0	5	6
208	R:R:V183	R:R:W205	15.94	No	Yes	0	5	5
209	R:R:C201	R:R:Q184	4.58	No	Yes	2	9	5
210	R:R:E204	R:R:Q185	5.1	No	No	0	3	4
211	R:R:E187	R:R:L202	6.63	No	No	0	1	4
212	R:R:E187	R:R:E204	12.69	No	No	0	1	3
213	R:R:F192	R:R:Y190	9.28	No	No	0	3	1
214	R:R:E195	R:R:Y190	10.1	No	No	0	4	1
215	R:R:E197	R:R:Y190	3.37	No	No	0	6	1
216	R:R:D191	R:R:Y194	3.45	No	Yes	0	3	1
217	R:R:H198	R:R:K196	11.79	Yes	No	0	1	3
218	R:R:E203	R:R:W205	4.36	No	Yes	0	5	5
219	R:R:Q211	R:R:W205	14.24	No	Yes	0	4	5
220	R:R:W205	R:R:Y214	11.58	Yes	Yes	0	5	6
221	R:R:P208	R:R:S207	3.56	No	Yes	0	1	6
222	R:R:S207	R:R:V209	3.23	Yes	No	0	6	1
223	R:R:H210	R:R:S207	12.55	No	Yes	0	4	6
224	R:R:E297	R:R:Q211	12.74	No	No	0	5	4
225	R:R:E297	R:R:K212	6.75	No	No	0	5	3
226	R:R:I218	R:R:Y214	13.3	No	Yes	0	5	6
227	R:R:M294	R:R:T215	4.52	Yes	No	0	5	5
228	R:R:M294	R:R:T216	4.52	Yes	No	1	5	5
229	R:R:T216	R:R:Y298	4.99	No	No	1	5	4
230	R:R:F217	R:R:I221	10.05	No	No	0	4	4
231	R:R:I218	R:R:L222	4.28	No	Yes	0	5	6
232	R:R:F223	R:R:L219	3.65	Yes	Yes	1	8	5
233	R:R:L219	R:R:L224	6.92	Yes	No	0	5	4
234	R:R:H290	R:R:L219	5.14	Yes	Yes	1	7	5
235	R:R:L219	R:R:M294	5.65	Yes	Yes	1	5	5
236	R:R:L224	R:R:V220	2.98	No	No	0	4	5
237	R:R:L225	R:R:V220	4.47	No	No	0	5	5
238	R:R:H290	R:R:L222	3.86	Yes	Yes	0	7	6
239	R:R:F223	R:R:L227	7.31	Yes	No	0	8	6
240	R:R:F223	R:R:H290	11.31	Yes	Yes	1	8	7
241	R:R:F282	R:R:P226	4.33	Yes	No	6	9	9
242	R:R:F282	R:R:L227	4.87	Yes	No	0	9	6
243	R:R:L233	R:R:V229	2.98	No	No	0	7	6
244	R:R:M230	R:R:Y234	5.99	No	Yes	0	8	9
245	R:R:F282	R:R:M230	8.71	Yes	No	0	9	8
246	R:R:L231	R:R:V279	4.47	No	No	0	5	8
247	R:R:M275	R:R:Y234	4.79	No	Yes	0	8	9
248	R:R:V279	R:R:Y234	3.79	No	Yes	0	8	9
249	R:R:I237	R:R:M275	5.83	Yes	No	0	9	8
250	R:R:I243	R:R:Y239	14.51	No	No	0	4	3
251	R:R:K244	R:R:Y239	7.17	No	No	0	6	3
252	R:R:E240	R:R:K244	6.75	No	No	0	5	6
253	R:R:K268	R:R:L241	7.05	No	No	0	7	8
254	R:R:K269	R:R:W242	3.48	No	Yes	0	5	4
255	R:R:V272	R:R:W242	3.68	No	Yes	0	7	4
256	R:R:I273	R:R:K269	8.72	No	No	0	6	5
257	R:R:M274	R:R:M335	10.11	No	No	8	8	7
258	R:R:C327	R:R:L281	3.17	No	No	0	6	7
259	R:R:C285	R:R:N324	9.45	No	Yes	0	8	9
260	R:R:F289	R:R:W286	4.01	Yes	Yes	1	6	8
261	R:R:H290	R:R:W286	3.17	Yes	Yes	1	7	8
262	R:R:N324	R:R:W286	4.52	Yes	Yes	1	9	8
263	R:R:P288	R:R:V317	3.53	No	No	0	9	7
264	R:R:F289	R:R:H290	5.66	Yes	Yes	1	6	7
265	R:R:F289	R:R:H293	18.1	Yes	No	0	6	5
266	R:R:F289	R:R:Q318	3.51	Yes	No	0	6	6
267	R:R:I313	R:R:V292	4.61	No	No	0	5	5
268	R:R:F314	R:R:V292	3.93	No	No	0	5	5
269	R:R:F314	R:R:H293	6.79	No	No	0	5	5
270	R:R:M294	R:R:Y298	7.18	Yes	No	1	5	4
271	R:R:M295	R:R:S299	6.13	No	No	0	4	3
272	R:R:F301	R:R:M295	13.68	Yes	No	0	1	4
273	R:R:F301	R:R:I296	7.54	Yes	No	0	1	4
274	R:R:E302	R:R:I296	13.66	No	No	0	2	4
275	R:R:K303	R:R:N300	9.79	No	No	0	4	2
276	R:R:E304	R:R:N300	11.83	No	No	0	5	2
277	R:R:F301	R:R:Y305	15.47	Yes	No	0	1	2
278	R:R:F301	R:R:I310	5.02	Yes	No	0	1	4
279	R:R:E302	R:R:I310	12.3	No	No	0	2	4
280	R:R:E304	R:R:Y305	3.37	No	No	0	5	2
281	R:R:D306	R:R:V308	7.3	No	No	0	1	3
282	R:R:I313	R:R:T309	3.04	No	No	0	5	3
283	R:R:F314	R:R:I310	3.77	No	No	0	5	4
284	R:R:N324	R:R:N328	13.62	Yes	Yes	1	9	9
285	R:R:N328	R:R:Y332	3.49	Yes	No	1	9	9
286	R:R:F334	R:R:I330	6.28	Yes	No	0	6	7
287	R:R:F334	R:R:F339	11.79	Yes	Yes	0	6	8
288	R:R:N336	R:R:N338	8.17	No	No	0	8	6
289	R:R:E337	R:R:K341	8.1	No	No	0	5	4
290	R:R:F339	R:R:V343	14.42	Yes	No	0	8	6
291	R:R:L281	R:R:T277	2.95	No	No	0	7	6
292	R:R:I316	R:R:I320	2.94	No	No	0	5	7
293	R:R:I330	R:R:M335	2.92	No	No	0	7	7
294	R:R:I264	R:R:K268	2.91	No	No	0	4	7
295	L:L:S119	R:R:Q105	2.89	No	Yes	0	0	5
296	R:R:I237	R:R:L241	2.85	Yes	No	0	9	8
297	R:R:G321	R:R:W286	2.81	No	Yes	0	7	8
298	L:L:L101	R:R:L14	2.77	No	No	0	0	7
299	L:L:K115	R:R:D307	2.77	No	No	0	0	2
300	R:R:A287	R:R:F223	2.77	No	Yes	0	6	8
301	L:L:E106	R:R:I26	2.73	No	No	0	0	7
302	R:R:A346	R:R:Y68	2.67	No	No	0	6	4
303	R:R:D306	R:R:D307	2.66	No	No	0	1	2
304	L:L:F118	R:R:S108	2.64	Yes	No	0	0	5
305	R:R:F289	R:R:V317	2.62	Yes	No	0	6	7
306	R:R:F25	R:R:T21	2.59	No	No	0	7	8
307	R:R:R72	R:R:T71	2.59	No	No	0	5	3
308	R:R:R160	R:R:T164	2.59	No	No	0	5	2
309	R:R:H18	R:R:L15	2.57	No	No	0	8	7
310	R:R:D191	R:R:H198	2.52	No	Yes	0	3	1
311	R:R:F96	R:R:L60	2.44	No	No	0	5	6
312	R:R:F61	R:R:L65	2.44	No	No	0	5	7
313	R:R:F339	R:R:N336	2.42	Yes	No	0	8	8
314	R:R:K268	R:R:W242	2.32	No	Yes	0	7	4
315	R:R:H210	R:R:W205	2.12	No	Yes	0	4	5
316	R:R:G113	R:R:G114	2.11	No	No	0	7	8
317	R:R:G177	R:R:P179	2.03	No	No	0	7	7
318	R:R:F116	R:R:W181	2	No	No	0	3	4
319	L:L:A105	L:L:G102	1.95	No	No	0	0	0
320	R:R:P179	R:R:S178	1.78	No	No	0	7	3
321	R:R:P38	R:R:V308	1.77	No	No	0	2	3
322	R:R:G238	R:R:I237	1.76	No	Yes	0	6	9
323	L:L:P100	L:L:T103	1.75	No	No	0	0	0
324	L:L:G102	L:L:L101	1.71	No	No	0	0	0
325	L:L:G116	R:R:L202	1.71	No	No	0	0	4
326	R:R:C285	R:R:V284	1.71	No	No	0	8	6
327	R:R:A271	R:R:M275	1.61	No	No	0	7	8
328	R:R:V49	R:R:V53	1.6	No	No	0	4	4
329	R:R:V168	R:R:V172	1.6	No	No	0	4	5
330	R:R:S207	R:R:T206	1.6	Yes	No	0	6	5
331	R:R:V272	R:R:V276	1.6	No	No	0	7	5
332	R:R:V278	R:R:V331	1.6	No	No	0	8	8
333	R:R:C201	R:R:L186	1.59	No	No	0	9	5
334	R:R:C285	R:R:L281	1.59	No	No	0	8	7
335	R:R:T309	R:R:V308	1.59	No	No	0	3	3
336	R:R:A47	R:R:L46	1.58	No	No	0	5	4
337	R:R:A115	R:R:L186	1.58	No	No	0	3	5
338	R:R:A283	R:R:L227	1.58	No	No	0	6	6
339	R:R:I107	R:R:V49	1.54	No	No	0	4	4
340	R:R:H149	R:R:P150	1.53	Yes	No	0	6	8
341	R:R:A27	R:R:Q24	1.52	No	No	0	5	8
342	R:R:M230	R:R:V278	1.52	No	No	0	8	8
343	R:R:M274	R:R:V331	1.52	No	No	8	8	8
344	R:R:M335	R:R:V331	1.52	No	No	8	7	8
345	L:L:S112	R:R:L34	1.5	No	No	0	0	5
346	R:R:L344	R:R:V343	1.49	No	No	0	5	6
347	L:L:L104	L:L:T103	1.47	No	No	0	0	0
348	R:R:C200	R:R:H198	1.47	No	Yes	0	4	1
349	R:R:I232	R:R:M228	1.46	No	No	0	3	4
350	R:R:I107	R:R:K45	1.45	No	No	0	4	5
351	R:R:I232	R:R:K236	1.45	No	No	0	3	4
352	R:R:I199	R:R:L186	1.43	No	No	0	4	5
353	R:R:K341	R:R:N342	1.4	No	Yes	0	4	6
354	R:R:L46	R:R:L50	1.38	No	No	0	4	5
355	R:R:L89	R:R:L93	1.38	No	No	0	6	7
356	R:R:D17	R:R:L14	1.36	No	No	0	8	7
357	R:R:E187	R:R:K189	1.35	No	No	0	1	1
358	R:R:E337	R:R:K340	1.35	No	No	0	5	8
359	L:L:E107	L:L:L104	1.33	No	No	0	0	0
360	R:R:R13	R:R:S12	1.32	No	No	0	7	7
361	R:R:R77	R:R:V70	1.31	No	No	0	7	7
362	R:R:R160	R:R:T158	1.29	No	No	0	5	7
363	R:R:R161	R:R:T158	1.29	No	No	0	5	7
364	R:R:I273	R:R:R270	1.25	No	No	0	6	7
365	R:R:K74	R:R:R77	1.24	No	No	0	5	7
366	R:R:L193	R:R:Y194	1.17	Yes	Yes	0	3	1
367	R:R:I243	R:R:W242	1.17	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F118	6.9725	4	2	0
2	L:L:F120	7.02286	7	2	0
3	L:L:R121	9.09	4	0	0
4	L:L:F122	7.3	4	0	0
5	R:R:N63	6.7125	4	1	9
6	R:R:V69	5.0725	4	0	7
7	R:R:M76	5.7975	4	4	7
8	R:R:F83	6.79833	6	3	7
9	R:R:D91	5.5	5	1	9
10	R:R:T95	5.4675	4	1	7
11	R:R:T102	5.5675	4	0	6
12	R:R:Q105	7.1325	4	2	5
13	R:R:W111	7.2975	4	2	8
14	R:R:P122	5.19	4	2	5
15	R:R:Q125	5.2925	4	2	7
16	R:R:V130	3.9125	4	0	6
17	R:R:E132	5.72833	6	1	9
18	R:R:M136	4.3675	4	1	8
19	R:R:H144	11.2275	4	0	7
20	R:R:H149	7.605	4	0	6
21	R:R:M153	4.184	5	7	6
22	R:R:Q156	9.385	4	7	4
23	R:R:Y157	8.7	4	0	6
24	R:R:M180	5.04	4	0	5
25	R:R:Q184	5.525	4	2	5
26	R:R:L193	3.2975	4	0	3
27	R:R:Y194	5.285	4	0	1
28	R:R:H198	5.8575	4	0	1
29	R:R:W205	9.648	5	0	5
30	R:R:S207	5.235	4	0	6
31	R:R:Y214	7.796	5	0	6
32	R:R:L219	5.34	4	1	5
33	R:R:L222	4.2225	4	0	6
34	R:R:F223	6.26	4	1	8
35	R:R:Y234	5.834	5	0	9
36	R:R:I237	4.534	5	0	9
37	R:R:W242	2.6625	4	0	4
38	R:R:F282	6.99	4	6	9
39	R:R:W286	4.128	5	1	8
40	R:R:F289	6.365	6	1	6
41	R:R:H290	5.828	5	1	7
42	R:R:M294	5.4675	4	1	5
43	R:R:F301	10.4275	4	0	1
44	R:R:N324	7.148	5	1	9
45	R:R:N328	7.192	5	1	9
46	R:R:F334	7.3275	4	0	6
47	R:R:F339	9.4525	4	0	8
48	R:R:N342	6.2325	4	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:T103	R:R:Y29	12.117	4.99	No	No	0	0	8
2	L:L:E106	R:R:R30	14.7519	9.3	No	No	0	0	4
3	R:R:R30	R:R:Y29	13.4371	20.58	No	No	0	4	8
4	L:L:E106	L:L:S109	38.7101	4.31	No	No	0	0	0
5	L:L:S109	R:R:L193	39.895	3	No	Yes	0	0	3
6	L:L:G116	R:R:C200	65.115	3.92	No	No	0	0	4
7	R:R:C200	R:R:H198	62.9255	1.47	No	Yes	0	4	1
8	R:R:D191	R:R:H198	59.5907	2.52	No	Yes	0	3	1
9	R:R:D191	R:R:Y194	58.4853	3.45	No	Yes	0	3	1
10	R:R:L193	R:R:Y194	52.8152	1.17	Yes	Yes	0	3	1
11	L:L:G116	R:R:V35	71.5566	5.52	No	No	0	0	5
12	L:L:F118	L:L:F120	10.6431	5.36	Yes	Yes	2	0	0
13	L:L:F120	R:R:P122	13.954	5.78	Yes	Yes	2	0	5
14	R:R:M180	R:R:P122	26.2459	6.71	Yes	Yes	0	5	5
15	L:L:R121	R:R:E203	14.8738	9.3	Yes	No	0	0	5
16	L:L:R121	R:R:H293	24.8807	10.16	Yes	No	0	0	5
17	R:R:F314	R:R:H293	100	6.79	No	No	0	5	5
18	R:R:F314	R:R:V292	88.7711	3.93	No	No	0	5	5
19	R:R:I313	R:R:V292	87.8009	4.61	No	No	0	5	5
20	R:R:I313	R:R:T309	86.8254	3.04	No	No	0	5	3
21	R:R:T309	R:R:V308	85.8446	1.59	No	No	0	3	3
22	R:R:P38	R:R:V308	80.861	1.77	No	No	0	2	3
23	R:R:P38	R:R:T37	74.7058	3.5	No	No	0	2	5
24	R:R:T37	R:R:V35	72.6116	4.76	No	No	0	5	5
25	R:R:M180	R:R:Y214	16.9786	4.79	Yes	Yes	0	5	6
26	L:L:R121	R:R:Y214	17.1085	5.14	Yes	Yes	0	0	6
27	R:R:I94	R:R:V129	10.2057	3.07	No	No	0	7	7
28	R:R:C98	R:R:I94	15.5948	6.55	No	No	0	7	7
29	R:R:C98	R:R:Q125	15.7035	7.63	No	Yes	0	7	7
30	R:R:F289	R:R:H293	80.0154	18.1	Yes	No	0	6	5
31	R:R:F289	R:R:W286	38.6889	4.01	Yes	Yes	1	6	8
32	R:R:F289	R:R:Q318	11.6027	3.51	Yes	No	0	6	6
33	R:R:Q318	R:R:T102	10.6457	7.09	No	Yes	0	6	6
34	L:L:E106	R:R:I26	23.7912	2.73	No	No	0	0	7
35	R:R:I26	R:R:T21	22.5294	4.56	No	No	0	7	8
36	R:R:H18	R:R:T21	19.9581	5.48	No	No	0	8	8
37	R:R:H18	R:R:L15	17.3656	2.57	No	No	0	8	7
38	R:R:L15	R:R:R22	16.0614	7.29	No	No	0	7	7
39	R:R:N19	R:R:R22	14.7519	8.44	No	No	0	8	7
40	R:R:N19	R:R:R16	13.4371	4.82	No	No	0	8	7
41	R:R:R16	R:R:S12	12.117	7.91	No	No	0	7	7
42	R:R:N324	R:R:W286	48.3565	4.52	Yes	Yes	1	9	8
43	R:R:E132	R:R:N324	27.5872	3.94	Yes	Yes	1	9	9
44	R:R:D91	R:R:E132	33.4959	9.09	Yes	Yes	1	9	9
45	R:R:D91	R:R:S325	10.2508	4.42	Yes	No	1	9	9
46	R:R:N324	R:R:N328	19.1072	13.62	Yes	Yes	1	9	9
47	R:R:D91	R:R:N328	18.3968	4.04	Yes	Yes	1	9	9
48	R:R:D91	R:R:N63	42.4981	6.73	Yes	Yes	1	9	9
49	R:R:L92	R:R:N63	21.8694	13.73	No	Yes	0	8	9
50	R:R:F289	R:R:H290	41.8407	5.66	Yes	Yes	1	6	7
51	R:R:H290	R:R:L222	33.1672	3.86	Yes	Yes	0	7	6
52	R:R:I133	R:R:L222	35.5715	4.28	No	Yes	0	7	6
53	R:R:F282	R:R:I133	26.3466	10.05	Yes	No	6	9	7
54	R:R:F282	R:R:M230	43.7573	8.71	Yes	No	0	9	8
55	R:R:M230	R:R:V278	30.0922	1.52	No	No	0	8	8
56	R:R:V278	R:R:V331	29.1194	1.6	No	No	0	8	8
57	R:R:M335	R:R:V331	27.0438	1.52	No	No	8	7	8
58	R:R:I330	R:R:M335	26.2565	2.92	No	No	0	7	7
59	R:R:F334	R:R:I330	25.4586	6.28	Yes	No	0	6	7
60	R:R:F334	R:R:L65	10.7465	7.31	Yes	No	0	6	7
61	R:R:F223	R:R:H290	17.6784	11.31	Yes	Yes	1	8	7
62	R:R:F223	R:R:L227	19.3007	7.31	Yes	No	0	8	6
63	R:R:F282	R:R:L227	18.6857	4.87	Yes	No	0	9	6
64	R:R:A88	R:R:N63	19.8627	3.13	No	Yes	0	9	9
65	R:R:A88	R:R:F67	18.7785	4.16	No	No	0	9	7
66	R:R:C85	R:R:F67	37.0984	4.19	No	No	0	6	7
67	R:R:C85	R:R:V70	34.8744	5.12	No	No	0	6	7
68	R:R:N81	R:R:V70	28.8066	2.96	No	No	0	8	7
69	R:R:M76	R:R:N81	25.3181	5.61	Yes	No	0	7	8
70	R:R:M76	R:R:V69	17.5061	3.04	Yes	Yes	0	7	7
71	R:R:F67	R:R:L92	20.5678	4.87	No	No	0	7	8
72	R:R:F334	R:R:F339	12.7293	11.79	Yes	Yes	0	6	8
73	R:R:A346	R:R:V69	12.8274	5.09	No	Yes	0	6	7
74	R:R:M76	R:R:N342	12.5093	8.41	Yes	Yes	4	7	6
75	R:R:E132	R:R:L87	23.0304	3.98	Yes	No	0	9	9
76	R:R:L87	R:R:T135	22.7998	4.42	No	No	0	9	8
77	R:R:I139	R:R:T135	21.0715	3.04	No	No	0	8	8
78	R:R:F83	R:R:I139	19.2901	5.02	Yes	No	0	7	8
79	R:R:E142	R:R:F83	15.5286	15.16	No	Yes	3	8	7
80	R:R:E142	R:R:Y157	14.8341	12.35	No	Yes	0	8	6
81	R:R:L222	R:R:V130	18.2298	4.47	Yes	Yes	0	6	6
82	R:R:A173	R:R:V130	10.7862	3.39	No	Yes	0	8	6
83	R:R:I139	R:R:R143	11.7326	6.26	No	No	0	8	9
84	R:R:M230	R:R:Y234	28.902	5.99	No	Yes	0	8	9
85	R:R:R143	R:R:Y234	12.0136	9.26	No	Yes	0	9	9
86	R:R:M275	R:R:Y234	24.438	4.79	No	Yes	0	8	9
87	R:R:I237	R:R:M275	22.3068	5.83	Yes	No	0	9	8
88	R:R:W205	R:R:Y214	11.8492	11.58	Yes	Yes	0	5	6
89	R:R:I218	R:R:Y214	14.28	13.3	No	Yes	0	5	6
90	R:R:I237	R:R:L241	16.4007	2.85	Yes	No	0	9	8
91	R:R:K268	R:R:L241	15.1707	7.05	No	No	0	7	8
92	R:R:K268	R:R:W242	12.6948	2.32	No	Yes	0	7	4
93	R:R:F314	R:R:I310	14.7519	3.77	No	No	0	5	4
94	R:R:F301	R:R:I310	10.7677	5.02	Yes	No	0	1	4
95	R:R:E132	R:R:I94	18.3862	4.1	Yes	No	0	9	7
96	R:R:I218	R:R:L222	14.5213	4.28	No	Yes	0	5	6
97	R:R:H290	R:R:W286	12.3423	3.17	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:T103	R:R:Y29	4.99	0	No	No	0	8	0	1
L:L:E106	R:R:R30	9.3	0	No	No	0	4	0	1
L:L:S109	R:R:L193	3	0	No	Yes	0	3	0	1
L:L:R113	R:R:R32	10.66	0	No	No	0	7	0	1
L:L:G116	R:R:V35	5.52	0	No	No	0	5	0	1
L:L:G116	R:R:C200	3.92	0	No	No	0	4	0	1
L:L:G117	R:R:C200	3.92	0	No	No	0	4	0	1
L:L:F118	R:R:Q105	5.86	2	Yes	Yes	0	5	0	1
L:L:F118	R:R:W111	14.03	2	Yes	Yes	0	8	0	1
L:L:F120	R:R:V101	5.24	2	Yes	No	0	5	0	1
L:L:F120	R:R:Q105	14.05	2	Yes	Yes	0	5	0	1
L:L:F120	R:R:W111	7.02	2	Yes	Yes	0	8	0	1
L:L:F120	R:R:P122	5.78	2	Yes	Yes	0	5	0	1
L:L:F120	R:R:Q125	3.51	2	Yes	Yes	0	7	0	1
L:L:F120	R:R:Q184	8.2	2	Yes	Yes	0	5	0	1
L:L:R121	R:R:E203	9.3	0	Yes	No	0	5	0	1
L:L:R121	R:R:Y214	5.14	0	Yes	Yes	0	6	0	1
L:L:R121	R:R:H293	10.16	0	Yes	No	0	5	0	1
L:L:F122	R:R:S126	5.28	0	Yes	No	0	3	0	1
L:L:F122	R:R:V129	7.87	0	Yes	No	0	7	0	1
L:L:F122	R:R:F289	4.29	0	Yes	Yes	0	6	0	1
R:R:L14	R:R:Q10	6.65	0	No	No	7	7	1	2
R:R:F11	R:R:L193	4.87	0	No	Yes	7	3	2	1
R:R:I26	R:R:T21	4.56	0	No	No	7	8	1	2
R:R:R30	R:R:Y29	20.58	0	No	No	4	8	1	1
R:R:L34	R:R:R32	4.86	0	No	No	5	7	1	1
R:R:L193	R:R:L34	4.15	0	Yes	No	3	5	1	1
R:R:T37	R:R:V35	4.76	0	No	No	5	5	2	1
R:R:C98	R:R:I94	6.55	0	No	No	7	7	2	2
R:R:I94	R:R:V129	3.07	0	No	No	7	7	2	1
R:R:C98	R:R:Q125	7.63	0	No	Yes	7	7	2	1
R:R:Q105	R:R:V101	5.73	2	Yes	No	5	5	1	1
R:R:Q125	R:R:V101	4.3	2	Yes	No	7	5	1	1
R:R:L104	R:R:S108	3	0	No	No	4	5	2	1
R:R:I107	R:R:S108	3.1	0	No	No	4	5	2	1
R:R:G113	R:R:W111	4.22	0	No	Yes	7	8	2	1
R:R:C118	R:R:W111	3.92	2	No	Yes	9	8	2	1
R:R:C118	R:R:Q184	4.58	2	No	Yes	9	5	2	1
R:R:C118	R:R:C201	7.28	2	No	No	9	9	2	2
R:R:P122	R:R:V121	3.53	2	Yes	No	5	5	1	2
R:R:Q125	R:R:V121	5.73	2	Yes	No	7	5	1	2
R:R:M180	R:R:P122	6.71	0	Yes	Yes	5	5	2	1
R:R:P122	R:R:Q184	4.74	2	Yes	Yes	5	5	1	1
R:R:M180	R:R:S126	4.6	0	Yes	No	5	3	2	1
R:R:V129	R:R:W286	6.13	0	No	Yes	7	8	1	2
R:R:P179	R:R:Y214	4.17	0	No	Yes	7	6	2	1
R:R:E203	R:R:M180	4.06	0	No	Yes	5	5	1	2
R:R:M180	R:R:Y214	4.79	0	Yes	Yes	5	6	2	1
R:R:C201	R:R:Q184	4.58	2	No	Yes	9	5	2	1
R:R:E187	R:R:L202	6.63	0	No	No	1	4	2	1
R:R:E203	R:R:W205	4.36	0	No	Yes	5	5	1	2
R:R:W205	R:R:Y214	11.58	0	Yes	Yes	5	6	2	1
R:R:I218	R:R:Y214	13.3	0	No	Yes	5	6	2	1
R:R:F289	R:R:W286	4.01	1	Yes	Yes	6	8	1	2
R:R:H290	R:R:W286	3.17	1	Yes	Yes	7	8	2	2
R:R:F289	R:R:H290	5.66	1	Yes	Yes	6	7	1	2
R:R:F289	R:R:H293	18.1	1	Yes	No	6	5	1	1
R:R:F289	R:R:Q318	3.51	1	Yes	No	6	6	1	2
R:R:F314	R:R:H293	6.79	0	No	No	5	5	2	1
L:L:S119	R:R:Q105	2.89	0	No	Yes	0	5	0	1
L:L:L101	R:R:L14	2.77	0	No	No	0	7	0	1
L:L:K115	R:R:D307	2.77	0	No	No	0	2	0	1
L:L:E106	R:R:I26	2.73	0	No	No	0	7	0	1
R:R:D306	R:R:D307	2.66	0	No	No	1	2	2	1
L:L:F118	R:R:S108	2.64	2	Yes	No	0	5	0	1
R:R:F289	R:R:V317	2.62	1	Yes	No	6	7	1	2
L:L:G116	R:R:L202	1.71	0	No	No	0	4	0	1
L:L:S112	R:R:L34	1.5	0	No	No	0	5	0	1
R:R:C200	R:R:H198	1.47	0	No	Yes	4	1	1	2
R:R:D17	R:R:L14	1.36	0	No	No	8	7	2	1
R:R:L193	R:R:Y194	1.17	0	Yes	Yes	3	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WZ2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.96
Number of Linked Nodes	324
Number of Links	367
Number of Hubs	48
Number of Links mediated by Hubs	169
Number of Communities	8
Number of Nodes involved in Communities	48
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	84408
Length Of Smallest Path	3
Average Path Length	17.4173
Length of Longest Path	48
Minimum Path Strength	1.275
Average Path Strength	5.58735
Maximum Path Strength	15.09
Minimum Path Correlation	0.7
Average Path Correlation	0.963049
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	65.1639
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.9727
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • binding • molecular function activator activity • signaling receptor binding • neuropeptide activity • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • orexigenic neuropeptide QRFP receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • neuropeptide signaling pathway • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • regulation of biological quality • blood circulation • behavior • locomotory behavior • regulation of behavior • feeding behavior • regulation of feeding behavior • regulation of multicellular organismal process • grooming behavior • extracellular region • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96P65
Sequence	>8WZ2_nogp_Chain_R E Q F S R L L R D H N L T R E Q F I A L Y R L R P L V Y T P E L P G R A K L A L V L T G V L I F A L A L F G N A L V F Y V V T R S K A M R T V T N I F I C S L A L S D L L I T F F C I P V T M L Q N I S D N W L G G A F I C K M V P F V Q S T A V V T E I L T M T C I A V E R H Q G L V H P F K M K W Q Y T N R R A F T M L G V V W L V A V I V G S P M W H V Q Q L E I K Y D F L Y E K E H I C C L E E W T S P V H Q K I Y T T F I L V I L F L L P L M V M L I L Y S K I G Y E L W I K M S K I A R K K K R A V I M M V T V V A L F A V C W A P F H V V H M M I E Y S N F E K E Y D D V T I K M I F A I V Q I I G F S N S I C N P I V Y A F M N E N F K K N V L S A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WZ2	A	Peptide	P518	QRFP	Homo sapiens	Orexigenic Neuropeptide QRFP	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.73	2024-06-19	doi.org/10.1038/s41421-024-00670-3
	8WZ2 (No Gprot)	A	Peptide	P518	QRFP	Homo sapiens	Orexigenic Neuropeptide QRFP	-		2.73	2024-06-19	doi.org/10.1038/s41421-024-00670-3
	8ZH8	A	Peptide	P518	QRFP	Homo sapiens	QRF-Amide	-	Gq/β1/γ1	3.19	2024-07-03	doi.org/10.1038/s41467-024-49030-5
	8ZH8 (No Gprot)	A	Peptide	P518	QRFP	Homo sapiens	QRF-Amide	-		3.19	2024-07-03	doi.org/10.1038/s41467-024-49030-5

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