Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:F118 6.9725420
2L:L:F120 7.02286720
3L:L:R121 9.09400
4L:L:F122 7.3400
5R:R:N63 6.7125419
6R:R:V69 5.0725407
7R:R:M76 5.7975447
8R:R:F83 6.79833637
9R:R:D91 5.5519
10R:R:T95 5.4675417
11R:R:T102 5.5675406
12R:R:Q105 7.1325425
13R:R:W111 7.2975428
14R:R:P122 5.19425
15R:R:Q125 5.2925427
16R:R:V130 3.9125406
17R:R:E132 5.72833619
18R:R:M136 4.3675418
19R:R:H144 11.2275407
20R:R:H149 7.605406
21R:R:M153 4.184576
22R:R:Q156 9.385474
23R:R:Y157 8.7406
24R:R:M180 5.04405
25R:R:Q184 5.525425
26R:R:L193 3.2975403
27R:R:Y194 5.285401
28R:R:H198 5.8575401
29R:R:W205 9.648505
30R:R:S207 5.235406
31R:R:Y214 7.796506
32R:R:L219 5.34415
33R:R:L222 4.2225406
34R:R:F223 6.26418
35R:R:Y234 5.834509
36R:R:I237 4.534509
37R:R:W242 2.6625404
38R:R:F282 6.99469
39R:R:W286 4.128518
40R:R:F289 6.365616
41R:R:H290 5.828517
42R:R:M294 5.4675415
43R:R:F301 10.4275401
44R:R:N324 7.148519
45R:R:N328 7.192519
46R:R:F334 7.3275406
47R:R:F339 9.4525408
48R:R:N342 6.2325446
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:T103 R:R:Y29 12.1174.99NoNo008
2L:L:E106 R:R:R30 14.75199.3NoNo004
3R:R:R30 R:R:Y29 13.437120.58NoNo048
4L:L:E106 L:L:S109 38.71014.31NoNo000
5L:L:S109 R:R:L193 39.8953NoYes003
6L:L:G116 R:R:C200 65.1153.92NoNo004
7R:R:C200 R:R:H198 62.92551.47NoYes041
8R:R:D191 R:R:H198 59.59072.52NoYes031
9R:R:D191 R:R:Y194 58.48533.45NoYes031
10R:R:L193 R:R:Y194 52.81521.17YesYes031
11L:L:G116 R:R:V35 71.55665.52NoNo005
12L:L:F118 L:L:F120 10.64315.36YesYes200
13L:L:F120 R:R:P122 13.9545.78YesYes205
14R:R:M180 R:R:P122 26.24596.71YesYes055
15L:L:R121 R:R:E203 14.87389.3YesNo005
16L:L:R121 R:R:H293 24.880710.16YesNo005
17R:R:F314 R:R:H293 1006.79NoNo055
18R:R:F314 R:R:V292 88.77113.93NoNo055
19R:R:I313 R:R:V292 87.80094.61NoNo055
20R:R:I313 R:R:T309 86.82543.04NoNo053
21R:R:T309 R:R:V308 85.84461.59NoNo033
22R:R:P38 R:R:V308 80.8611.77NoNo023
23R:R:P38 R:R:T37 74.70583.5NoNo025
24R:R:T37 R:R:V35 72.61164.76NoNo055
25R:R:M180 R:R:Y214 16.97864.79YesYes056
26L:L:R121 R:R:Y214 17.10855.14YesYes006
27R:R:I94 R:R:V129 10.20573.07NoNo077
28R:R:C98 R:R:I94 15.59486.55NoNo077
29R:R:C98 R:R:Q125 15.70357.63NoYes077
30R:R:F289 R:R:H293 80.015418.1YesNo065
31R:R:F289 R:R:W286 38.68894.01YesYes168
32R:R:F289 R:R:Q318 11.60273.51YesNo066
33R:R:Q318 R:R:T102 10.64577.09NoYes066
34L:L:E106 R:R:I26 23.79122.73NoNo007
35R:R:I26 R:R:T21 22.52944.56NoNo078
36R:R:H18 R:R:T21 19.95815.48NoNo088
37R:R:H18 R:R:L15 17.36562.57NoNo087
38R:R:L15 R:R:R22 16.06147.29NoNo077
39R:R:N19 R:R:R22 14.75198.44NoNo087
40R:R:N19 R:R:R16 13.43714.82NoNo087
41R:R:R16 R:R:S12 12.1177.91NoNo077
42R:R:N324 R:R:W286 48.35654.52YesYes198
43R:R:E132 R:R:N324 27.58723.94YesYes199
44R:R:D91 R:R:E132 33.49599.09YesYes199
45R:R:D91 R:R:S325 10.25084.42YesNo199
46R:R:N324 R:R:N328 19.107213.62YesYes199
47R:R:D91 R:R:N328 18.39684.04YesYes199
48R:R:D91 R:R:N63 42.49816.73YesYes199
49R:R:L92 R:R:N63 21.869413.73NoYes089
50R:R:F289 R:R:H290 41.84075.66YesYes167
51R:R:H290 R:R:L222 33.16723.86YesYes076
52R:R:I133 R:R:L222 35.57154.28NoYes076
53R:R:F282 R:R:I133 26.346610.05YesNo697
54R:R:F282 R:R:M230 43.75738.71YesNo098
55R:R:M230 R:R:V278 30.09221.52NoNo088
56R:R:V278 R:R:V331 29.11941.6NoNo088
57R:R:M335 R:R:V331 27.04381.52NoNo878
58R:R:I330 R:R:M335 26.25652.92NoNo077
59R:R:F334 R:R:I330 25.45866.28YesNo067
60R:R:F334 R:R:L65 10.74657.31YesNo067
61R:R:F223 R:R:H290 17.678411.31YesYes187
62R:R:F223 R:R:L227 19.30077.31YesNo086
63R:R:F282 R:R:L227 18.68574.87YesNo096
64R:R:A88 R:R:N63 19.86273.13NoYes099
65R:R:A88 R:R:F67 18.77854.16NoNo097
66R:R:C85 R:R:F67 37.09844.19NoNo067
67R:R:C85 R:R:V70 34.87445.12NoNo067
68R:R:N81 R:R:V70 28.80662.96NoNo087
69R:R:M76 R:R:N81 25.31815.61YesNo078
70R:R:M76 R:R:V69 17.50613.04YesYes077
71R:R:F67 R:R:L92 20.56784.87NoNo078
72R:R:F334 R:R:F339 12.729311.79YesYes068
73R:R:A346 R:R:V69 12.82745.09NoYes067
74R:R:M76 R:R:N342 12.50938.41YesYes476
75R:R:E132 R:R:L87 23.03043.98YesNo099
76R:R:L87 R:R:T135 22.79984.42NoNo098
77R:R:I139 R:R:T135 21.07153.04NoNo088
78R:R:F83 R:R:I139 19.29015.02YesNo078
79R:R:E142 R:R:F83 15.528615.16NoYes387
80R:R:E142 R:R:Y157 14.834112.35NoYes086
81R:R:L222 R:R:V130 18.22984.47YesYes066
82R:R:A173 R:R:V130 10.78623.39NoYes086
83R:R:I139 R:R:R143 11.73266.26NoNo089
84R:R:M230 R:R:Y234 28.9025.99NoYes089
85R:R:R143 R:R:Y234 12.01369.26NoYes099
86R:R:M275 R:R:Y234 24.4384.79NoYes089
87R:R:I237 R:R:M275 22.30685.83YesNo098
88R:R:W205 R:R:Y214 11.849211.58YesYes056
89R:R:I218 R:R:Y214 14.2813.3NoYes056
90R:R:I237 R:R:L241 16.40072.85YesNo098
91R:R:K268 R:R:L241 15.17077.05NoNo078
92R:R:K268 R:R:W242 12.69482.32NoYes074
93R:R:F314 R:R:I310 14.75193.77NoNo054
94R:R:F301 R:R:I310 10.76775.02YesNo014
95R:R:E132 R:R:I94 18.38624.1YesNo097
96R:R:I218 R:R:L222 14.52134.28NoYes056
97R:R:H290 R:R:W286 12.34233.17YesYes178
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:T103 R:R:Y29 4.99 0 No No 0 8 0 1
L:L:E106 R:R:R30 9.3 0 No No 0 4 0 1
L:L:S109 R:R:L193 3 0 No Yes 0 3 0 1
L:L:R113 R:R:R32 10.66 0 No No 0 7 0 1
L:L:G116 R:R:V35 5.52 0 No No 0 5 0 1
L:L:G116 R:R:C200 3.92 0 No No 0 4 0 1
L:L:G117 R:R:C200 3.92 0 No No 0 4 0 1
L:L:F118 R:R:Q105 5.86 2 Yes Yes 0 5 0 1
L:L:F118 R:R:W111 14.03 2 Yes Yes 0 8 0 1
L:L:F120 R:R:V101 5.24 2 Yes No 0 5 0 1
L:L:F120 R:R:Q105 14.05 2 Yes Yes 0 5 0 1
L:L:F120 R:R:W111 7.02 2 Yes Yes 0 8 0 1
L:L:F120 R:R:P122 5.78 2 Yes Yes 0 5 0 1
L:L:F120 R:R:Q125 3.51 2 Yes Yes 0 7 0 1
L:L:F120 R:R:Q184 8.2 2 Yes Yes 0 5 0 1
L:L:R121 R:R:E203 9.3 0 Yes No 0 5 0 1
L:L:R121 R:R:Y214 5.14 0 Yes Yes 0 6 0 1
L:L:R121 R:R:H293 10.16 0 Yes No 0 5 0 1
L:L:F122 R:R:S126 5.28 0 Yes No 0 3 0 1
L:L:F122 R:R:V129 7.87 0 Yes No 0 7 0 1
L:L:F122 R:R:F289 4.29 0 Yes Yes 0 6 0 1
R:R:L14 R:R:Q10 6.65 0 No No 7 7 1 2
R:R:F11 R:R:L193 4.87 0 No Yes 7 3 2 1
R:R:I26 R:R:T21 4.56 0 No No 7 8 1 2
R:R:R30 R:R:Y29 20.58 0 No No 4 8 1 1
R:R:L34 R:R:R32 4.86 0 No No 5 7 1 1
R:R:L193 R:R:L34 4.15 0 Yes No 3 5 1 1
R:R:T37 R:R:V35 4.76 0 No No 5 5 2 1
R:R:C98 R:R:I94 6.55 0 No No 7 7 2 2
R:R:I94 R:R:V129 3.07 0 No No 7 7 2 1
R:R:C98 R:R:Q125 7.63 0 No Yes 7 7 2 1
R:R:Q105 R:R:V101 5.73 2 Yes No 5 5 1 1
R:R:Q125 R:R:V101 4.3 2 Yes No 7 5 1 1
R:R:L104 R:R:S108 3 0 No No 4 5 2 1
R:R:I107 R:R:S108 3.1 0 No No 4 5 2 1
R:R:G113 R:R:W111 4.22 0 No Yes 7 8 2 1
R:R:C118 R:R:W111 3.92 2 No Yes 9 8 2 1
R:R:C118 R:R:Q184 4.58 2 No Yes 9 5 2 1
R:R:C118 R:R:C201 7.28 2 No No 9 9 2 2
R:R:P122 R:R:V121 3.53 2 Yes No 5 5 1 2
R:R:Q125 R:R:V121 5.73 2 Yes No 7 5 1 2
R:R:M180 R:R:P122 6.71 0 Yes Yes 5 5 2 1
R:R:P122 R:R:Q184 4.74 2 Yes Yes 5 5 1 1
R:R:M180 R:R:S126 4.6 0 Yes No 5 3 2 1
R:R:V129 R:R:W286 6.13 0 No Yes 7 8 1 2
R:R:P179 R:R:Y214 4.17 0 No Yes 7 6 2 1
R:R:E203 R:R:M180 4.06 0 No Yes 5 5 1 2
R:R:M180 R:R:Y214 4.79 0 Yes Yes 5 6 2 1
R:R:C201 R:R:Q184 4.58 2 No Yes 9 5 2 1
R:R:E187 R:R:L202 6.63 0 No No 1 4 2 1
R:R:E203 R:R:W205 4.36 0 No Yes 5 5 1 2
R:R:W205 R:R:Y214 11.58 0 Yes Yes 5 6 2 1
R:R:I218 R:R:Y214 13.3 0 No Yes 5 6 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:H290 R:R:W286 3.17 1 Yes Yes 7 8 2 2
R:R:F289 R:R:H290 5.66 1 Yes Yes 6 7 1 2
R:R:F289 R:R:H293 18.1 1 Yes No 6 5 1 1
R:R:F289 R:R:Q318 3.51 1 Yes No 6 6 1 2
R:R:F314 R:R:H293 6.79 0 No No 5 5 2 1
L:L:S119 R:R:Q105 2.89 0 No Yes 0 5 0 1
L:L:L101 R:R:L14 2.77 0 No No 0 7 0 1
L:L:K115 R:R:D307 2.77 0 No No 0 2 0 1
L:L:E106 R:R:I26 2.73 0 No No 0 7 0 1
R:R:D306 R:R:D307 2.66 0 No No 1 2 2 1
L:L:F118 R:R:S108 2.64 2 Yes No 0 5 0 1
R:R:F289 R:R:V317 2.62 1 Yes No 6 7 1 2
L:L:G116 R:R:L202 1.71 0 No No 0 4 0 1
L:L:S112 R:R:L34 1.5 0 No No 0 5 0 1
R:R:C200 R:R:H198 1.47 0 No Yes 4 1 1 2
R:R:D17 R:R:L14 1.36 0 No No 8 7 2 1
R:R:L193 R:R:Y194 1.17 0 Yes Yes 3 1 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8WZ2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.96
Number of Linked Nodes 324
Number of Links 367
Number of Hubs 48
Number of Links mediated by Hubs 169
Number of Communities 8
Number of Nodes involved in Communities 48
Number of Links involved in Communities 64
Path Summary
Number Of Nodes in MetaPath 98
Number Of Links MetaPath 97
Number of Shortest Paths 84408
Length Of Smallest Path 3
Average Path Length 17.4173
Length of Longest Path 48
Minimum Path Strength 1.275
Average Path Strength 5.58735
Maximum Path Strength 15.09
Minimum Path Correlation 0.7
Average Path Correlation 0.962953
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 65.0277
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.9727
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ96P65
Sequence
>8WZ2_nogp_Chain_R
EQFSRLLRD HNLTREQFI ALYRLRPLV YTPELPGRA KLALVLTGV 
LIFALALFG NALVFYVVT RSKAMRTVT NIFICSLAL SDLLITFFC 
IPVTMLQNI SDNWLGGAF ICKMVPFVQ STAVVTEIL TMTCIAVER 
HQGLVHPFK MKWQYTNRR AFTMLGVVW LVAVIVGSP MWHVQQLEI 
KYDFLYEKE HICCLEEWT SPVHQKIYT TFILVILFL LPLMVMLIL 
YSKIGYELW IKMSKIARK KKRAVIMMV TVVALFAVC WAPFHVVHM 
MIEYSNFEK EYDDVTIKM IFAIVQIIG FSNSICNPI VYAFMNENF 
KKNVLSA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZH8APeptideP518QRFPHomo sapiensQRF-Amide-Gq/β1/γ13.192024-07-0310.1038/s41467-024-49030-5
8ZH8 (No Gprot) APeptideP518QRFPHomo sapiensQRF-Amide-3.192024-07-0310.1038/s41467-024-49030-5
8WZ2APeptideP518QRFPHomo sapiensOrexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ22.732024-06-1910.1038/s41421-024-00670-3
8WZ2 (No Gprot) APeptideP518QRFPHomo sapiensOrexigenic Neuropeptide QRFP-2.732024-06-1910.1038/s41421-024-00670-3




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Download 8WZ2_nogp.zip



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