psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A3	R:R:I6	3.25	No	No	0	4	4
2	L:L:E11	R:R:A3	4.53	No	No	0	0	4
3	R:R:L4	R:R:N5	8.24	No	No	4	4	7
4	L:L:Y15	R:R:L4	4.69	Yes	No	4	0	4
5	L:L:Y15	R:R:N5	6.98	Yes	No	4	0	7
6	R:R:I6	R:R:Q10	6.86	No	No	0	4	7
7	R:R:P8	R:R:T7	3.5	No	No	6	8	5
8	R:R:E9	R:R:T7	5.64	No	No	6	7	5
9	R:R:Q10	R:R:T7	11.34	No	No	0	7	5
10	R:R:E9	R:R:P8	3.14	No	No	6	7	8
11	R:R:F11	R:R:L15	12.18	No	No	2	7	7
12	R:R:F11	R:R:F25	8.57	No	Yes	2	7	7
13	R:R:D17	R:R:L14	5.43	No	No	0	8	7
14	R:R:F25	R:R:L15	3.65	Yes	No	2	7	7
15	R:R:D17	R:R:H18	5.04	No	Yes	0	8	8
16	L:L:G3	R:R:H18	3.18	No	Yes	2	0	8
17	L:L:P4	R:R:H18	9.15	No	Yes	2	0	8
18	L:L:L5	R:R:H18	23.14	Yes	Yes	2	0	8
19	R:R:L20	R:R:Q24	5.32	No	No	2	5	8
20	L:L:L5	R:R:L20	4.15	Yes	No	2	0	5
21	R:R:E23	R:R:T21	4.23	No	No	2	6	8
22	R:R:Q24	R:R:T21	9.92	No	No	2	8	8
23	R:R:E195	R:R:R22	11.63	No	No	0	4	7
24	R:R:E23	R:R:Q24	8.92	No	No	2	6	8
25	R:R:F25	R:R:Y29	17.54	Yes	Yes	2	7	8
26	L:L:L5	R:R:F25	3.65	Yes	Yes	2	0	7
27	R:R:I26	R:R:Y194	3.63	No	No	0	7	1
28	R:R:A27	R:R:R30	4.15	No	No	0	5	4
29	R:R:L31	R:R:Y29	8.21	No	Yes	0	6	8
30	L:L:L5	R:R:Y29	9.38	Yes	Yes	2	0	8
31	L:L:L8	R:R:Y29	10.55	No	Yes	0	0	8
32	L:L:A9	R:R:Y29	9.34	No	Yes	0	0	8
33	L:L:L12	R:R:L31	4.15	No	No	0	0	6
34	L:L:N13	R:R:L31	5.49	No	No	0	0	6
35	L:L:N13	R:R:R32	6.03	No	No	0	0	7
36	L:L:R17	R:R:R32	10.66	No	No	0	0	7
37	R:R:D191	R:R:L34	4.07	No	Yes	0	3	5
38	L:L:Y15	R:R:L34	3.52	Yes	Yes	4	0	5
39	L:L:S16	R:R:L34	3	No	Yes	4	0	5
40	R:R:H198	R:R:V35	11.07	No	No	0	1	5
41	L:L:K18	R:R:V35	3.04	No	No	0	0	5
42	R:R:P38	R:R:Y36	4.17	Yes	No	7	2	4
43	R:R:D307	R:R:Y36	4.6	No	No	7	2	4
44	R:R:D109	R:R:T37	10.12	No	No	0	4	5
45	R:R:D307	R:R:P38	3.22	No	Yes	7	2	2
46	L:L:K19	R:R:P38	5.02	No	Yes	0	0	2
47	R:R:E39	R:R:K45	10.8	No	No	0	3	5
48	R:R:L40	R:R:P41	3.28	No	Yes	0	3	3
49	R:R:K311	R:R:L40	15.51	No	No	0	2	3
50	R:R:A44	R:R:P41	5.61	No	Yes	0	1	3
51	R:R:A44	R:R:M312	3.22	No	No	0	1	1
52	R:R:I107	R:R:K45	10.18	No	No	0	4	5
53	R:R:A315	R:R:L48	4.73	No	No	0	4	4
54	R:R:I107	R:R:V49	3.07	No	No	0	4	4
55	R:R:L54	R:R:L58	5.54	No	No	0	5	5
56	R:R:I55	R:R:I99	2.94	No	Yes	0	8	7
57	R:R:I55	R:R:S323	3.1	No	No	0	8	5
58	R:R:I326	R:R:I55	4.42	Yes	No	0	7	8
59	R:R:F56	R:R:T95	5.19	Yes	No	1	6	7
60	R:R:F56	R:R:F96	4.29	Yes	No	1	6	5
61	R:R:F56	R:R:P100	4.33	Yes	No	0	6	8
62	R:R:I326	R:R:L58	2.85	Yes	No	0	7	5
63	R:R:A59	R:R:T95	5.03	No	No	1	8	7
64	R:R:A59	R:R:S325	3.42	No	Yes	1	8	9
65	R:R:A59	R:R:I326	3.25	No	Yes	1	8	7
66	R:R:F61	R:R:G62	3.01	No	No	0	5	8
67	R:R:A88	R:R:N63	3.13	No	Yes	0	9	9
68	R:R:D91	R:R:N63	13.46	Yes	Yes	1	9	9
69	R:R:L92	R:R:N63	4.12	No	Yes	0	8	9
70	R:R:N63	R:R:P329	6.52	Yes	No	1	9	9
71	R:R:L65	R:R:V69	2.98	No	Yes	0	7	7
72	R:R:A88	R:R:V66	3.39	No	No	0	9	9
73	R:R:C85	R:R:F67	4.19	No	Yes	0	6	7
74	R:R:A88	R:R:F67	4.16	No	Yes	0	9	7
75	R:R:F67	R:R:L89	6.09	Yes	No	0	7	6
76	R:R:F67	R:R:L92	4.87	Yes	No	0	7	8
77	R:R:R72	R:R:Y68	8.23	No	No	0	5	4
78	R:R:F339	R:R:V69	11.8	No	Yes	9	8	7
79	R:R:V343	R:R:V69	3.21	No	Yes	9	6	7
80	R:R:T71	R:R:V70	3.17	No	No	0	3	7
81	R:R:N81	R:R:V70	2.96	Yes	No	0	8	7
82	R:R:M76	R:R:S73	4.6	Yes	No	0	7	5
83	R:R:K74	R:R:R77	8.66	No	No	0	5	7
84	R:R:M76	R:R:N81	5.61	Yes	Yes	0	7	8
85	R:R:M76	R:R:N342	12.62	Yes	No	0	7	6
86	R:R:N81	R:R:T78	5.85	Yes	No	0	8	8
87	R:R:E142	R:R:V79	4.28	Yes	No	5	8	6
88	R:R:V79	R:R:Y157	16.4	No	Yes	5	6	6
89	R:R:A162	R:R:V79	5.09	No	No	0	7	6
90	R:R:E142	R:R:T80	12.7	Yes	No	5	8	8
91	R:R:T80	R:R:Y157	3.75	No	Yes	5	8	6
92	R:R:I82	R:R:N159	5.66	No	No	10	6	1
93	R:R:A162	R:R:I82	4.87	No	No	0	7	6
94	R:R:F163	R:R:I82	3.77	No	No	10	3	6
95	R:R:F83	R:R:I139	5.02	Yes	No	0	7	8
96	R:R:E142	R:R:F83	8.16	Yes	Yes	0	8	7
97	R:R:F83	R:R:M165	7.46	Yes	No	0	7	6
98	R:R:F83	R:R:L166	4.87	Yes	No	0	7	7
99	R:R:S86	R:R:T135	7.99	No	No	0	9	8
100	R:R:L166	R:R:S86	9.01	No	No	0	7	9
101	R:R:S86	R:R:W170	3.71	No	No	0	9	9
102	R:R:L87	R:R:T135	7.37	Yes	No	0	9	8
103	R:R:L87	R:R:M136	4.24	Yes	Yes	0	9	8
104	R:R:I139	R:R:L87	2.85	No	Yes	0	8	9
105	R:R:L87	R:R:Y332	4.69	Yes	No	0	9	9
106	R:R:L89	R:R:W170	5.69	No	No	0	6	9
107	R:R:S90	R:R:T131	6.4	No	No	0	8	7
108	R:R:D91	R:R:E132	6.5	Yes	Yes	1	9	9
109	R:R:D91	R:R:S325	4.42	Yes	Yes	1	9	9
110	R:R:D91	R:R:P329	11.27	Yes	No	1	9	9
111	R:R:A128	R:R:L93	3.15	No	No	0	8	7
112	R:R:C98	R:R:I94	6.55	No	Yes	0	7	7
113	R:R:A128	R:R:I94	3.25	No	Yes	0	8	7
114	R:R:I94	R:R:V129	3.07	Yes	Yes	0	7	7
115	R:R:E132	R:R:I94	6.83	Yes	Yes	0	9	7
116	R:R:S325	R:R:T95	3.2	Yes	No	1	9	7
117	R:R:F97	R:R:M120	3.73	No	No	0	5	4
118	R:R:F97	R:R:V124	14.42	No	No	0	5	5
119	R:R:C98	R:R:Q125	6.1	No	Yes	0	7	7
120	R:R:C98	R:R:F322	4.19	No	Yes	0	7	7
121	R:R:I99	R:R:P100	5.08	Yes	No	0	7	8
122	R:R:F322	R:R:I99	5.02	Yes	Yes	0	7	7
123	R:R:V101	R:R:V121	6.41	No	Yes	1	5	5
124	R:R:Q125	R:R:V101	4.3	Yes	No	1	7	5
125	L:L:F24	R:R:V101	6.55	Yes	No	1	0	5
126	R:R:N106	R:R:T102	2.92	No	Yes	0	5	6
127	R:R:Q318	R:R:T102	7.09	Yes	Yes	1	6	6
128	R:R:F322	R:R:T102	6.49	Yes	Yes	1	7	6
129	L:L:?27	R:R:T102	3.65	Yes	Yes	1	0	6
130	L:L:F22	R:R:Q105	4.68	Yes	No	1	0	5
131	L:L:F24	R:R:Q105	11.71	Yes	No	1	0	5
132	R:R:K311	R:R:N106	4.2	No	No	0	2	5
133	R:R:A315	R:R:N106	6.25	No	No	0	4	5
134	R:R:N110	R:R:S108	2.98	No	No	0	5	5
135	L:L:F22	R:R:S108	3.96	Yes	No	0	0	5
136	L:L:G21	R:R:D109	3.35	No	No	0	0	4
137	R:R:G113	R:R:W111	5.63	No	Yes	1	7	8
138	R:R:I117	R:R:W111	3.52	No	Yes	1	6	8
139	R:R:C118	R:R:W111	3.92	No	Yes	1	9	8
140	R:R:C201	R:R:W111	13.06	No	Yes	1	9	8
141	L:L:F22	R:R:W111	15.03	Yes	Yes	1	0	8
142	L:L:F24	R:R:W111	5.01	Yes	Yes	1	0	8
143	R:R:G113	R:R:I117	3.53	No	No	1	7	6
144	R:R:A115	R:R:L186	3.15	No	No	0	3	5
145	R:R:F116	R:R:I117	3.77	No	No	0	3	6
146	R:R:C118	R:R:Q184	4.58	No	Yes	1	9	5
147	R:R:C118	R:R:C201	7.28	No	No	1	9	9
148	R:R:K119	R:R:W181	11.6	No	No	0	7	4
149	R:R:M120	R:R:V121	3.04	No	Yes	0	4	5
150	R:R:P122	R:R:V121	3.53	Yes	Yes	1	5	5
151	R:R:Q125	R:R:V121	4.3	Yes	Yes	1	7	5
152	R:R:M180	R:R:P122	3.35	Yes	Yes	0	5	5
153	R:R:P122	R:R:Q184	12.63	Yes	Yes	1	5	5
154	L:L:F24	R:R:P122	7.22	Yes	Yes	1	0	5
155	R:R:F123	R:R:T127	7.78	No	No	0	6	5
156	L:L:?27	R:R:Q125	6.59	Yes	Yes	1	0	7
157	R:R:M180	R:R:S126	4.6	Yes	No	0	5	3
158	L:L:F26	R:R:S126	6.61	Yes	No	0	0	3
159	R:R:I133	R:R:V129	3.07	Yes	Yes	1	7	7
160	R:R:L222	R:R:V129	2.98	Yes	Yes	1	6	7
161	R:R:V129	R:R:W286	4.9	Yes	Yes	1	7	8
162	L:L:F26	R:R:V129	6.55	Yes	Yes	0	0	7
163	R:R:L134	R:R:V130	2.98	No	Yes	0	6	6
164	R:R:A173	R:R:V130	3.39	No	Yes	0	8	6
165	R:R:V130	R:R:V176	4.81	Yes	No	0	6	5
166	R:R:L222	R:R:V130	7.45	Yes	Yes	0	6	6
167	R:R:T131	R:R:W170	13.34	No	No	0	7	9
168	R:R:A173	R:R:T131	3.36	No	No	0	8	7
169	R:R:E132	R:R:M136	4.06	Yes	Yes	0	9	8
170	R:R:E132	R:R:W286	3.27	Yes	Yes	1	9	8
171	R:R:E132	R:R:N324	6.57	Yes	Yes	1	9	9
172	R:R:I133	R:R:L222	8.56	Yes	Yes	1	7	6
173	R:R:I133	R:R:P226	3.39	Yes	No	0	7	9
174	R:R:F282	R:R:I133	5.02	No	Yes	0	9	7
175	R:R:L134	R:R:V169	5.96	No	No	0	6	7
176	R:R:L134	R:R:V172	2.98	No	No	0	6	5
177	R:R:M136	R:R:M230	2.89	Yes	No	0	8	8
178	R:R:F282	R:R:M136	3.73	No	Yes	0	9	8
179	R:R:M136	R:R:N328	9.82	Yes	Yes	0	8	9
180	R:R:P226	R:R:T137	3.5	No	No	0	9	7
181	R:R:T137	R:R:V229	3.17	No	Yes	0	7	6
182	R:R:C138	R:R:M165	3.24	No	No	0	7	6
183	R:R:I139	R:R:R143	6.26	No	No	0	8	9
184	R:R:A140	R:R:M230	3.22	No	No	3	9	8
185	R:R:A140	R:R:Y234	5.34	No	Yes	3	9	9
186	R:R:L233	R:R:V141	2.98	No	No	0	7	7
187	R:R:E142	R:R:Y157	12.35	Yes	Yes	5	8	6
188	R:R:R143	R:R:Y234	11.32	No	Yes	3	9	9
189	R:R:M275	R:R:R143	4.96	Yes	No	3	8	9
190	R:R:H144	R:R:V148	9.69	No	No	0	7	7
191	R:R:H144	R:R:L233	15.43	No	No	0	7	7
192	R:R:H144	R:R:K236	10.48	No	No	0	7	4
193	R:R:H149	R:R:Q145	4.95	Yes	No	11	6	5
194	R:R:K152	R:R:Q145	4.07	No	No	11	4	5
195	R:R:M153	R:R:Q145	4.08	Yes	No	0	6	5
196	R:R:G146	R:R:M153	3.49	No	Yes	0	8	6
197	R:R:I237	R:R:L147	4.28	Yes	No	3	9	8
198	R:R:L147	R:R:L241	4.15	No	No	3	8	8
199	R:R:H149	R:R:V148	8.3	Yes	No	0	6	7
200	R:R:H149	R:R:K152	10.48	Yes	No	11	6	4
201	R:R:F151	R:R:K154	4.96	No	No	0	5	4
202	R:R:M153	R:R:Y157	4.79	Yes	Yes	0	6	6
203	R:R:Q156	R:R:W155	7.67	No	No	0	4	4
204	R:R:Q156	R:R:R161	4.67	No	No	0	4	5
205	R:R:F163	R:R:N159	3.62	No	No	10	3	1
206	R:R:I175	R:R:L171	2.85	No	No	0	4	5
207	R:R:F217	R:R:V176	3.93	No	No	0	4	5
208	R:R:P179	R:R:S178	5.34	No	No	0	7	3
209	R:R:M180	R:R:V183	3.04	Yes	Yes	0	5	5
210	R:R:M180	R:R:Y214	11.97	Yes	Yes	0	5	6
211	R:R:E203	R:R:V183	5.7	Yes	Yes	1	5	5
212	R:R:V183	R:R:W205	20.84	Yes	Yes	1	5	5
213	R:R:C201	R:R:Q184	4.58	No	Yes	1	9	5
214	R:R:E203	R:R:Q184	3.82	Yes	Yes	1	5	5
215	L:L:F24	R:R:Q184	10.54	Yes	Yes	1	0	5
216	R:R:E204	R:R:Q185	19.11	No	No	0	3	4
217	R:R:I188	R:R:L186	2.85	No	No	0	3	5
218	R:R:E187	R:R:K189	5.4	No	No	0	1	1
219	R:R:C200	R:R:K189	6.47	No	No	0	4	1
220	L:L:K18	R:R:K189	2.87	No	No	0	0	1
221	R:R:F192	R:R:Y190	3.09	No	No	0	3	1
222	R:R:E195	R:R:Y190	6.73	No	No	0	4	1
223	R:R:H198	R:R:K196	18.34	No	No	0	1	3
224	L:L:G20	R:R:C200	3.92	No	No	0	0	4
225	L:L:S23	R:R:L202	4.5	No	No	0	0	4
226	R:R:E203	R:R:W205	10.9	Yes	Yes	1	5	5
227	L:L:S23	R:R:E203	10.06	No	Yes	0	0	5
228	L:L:R25	R:R:E203	5.82	Yes	Yes	1	0	5
229	R:R:Q211	R:R:W205	27.38	No	Yes	0	4	5
230	R:R:W205	R:R:Y214	5.79	Yes	Yes	0	5	6
231	R:R:H210	R:R:T206	4.11	No	No	0	4	5
232	R:R:P208	R:R:S207	5.34	No	No	0	1	6
233	R:R:S207	R:R:V209	6.46	No	No	0	6	1
234	R:R:E297	R:R:Q211	14.02	No	No	0	5	4
235	L:L:R25	R:R:Q211	3.5	Yes	No	0	0	4
236	R:R:K212	R:R:Y298	15.53	No	No	0	3	4
237	R:R:I218	R:R:Y214	13.3	No	Yes	0	5	6
238	L:L:R25	R:R:Y214	12.35	Yes	Yes	0	0	6
239	R:R:H293	R:R:T215	4.11	Yes	No	1	5	5
240	R:R:E297	R:R:T215	7.06	No	No	0	5	5
241	L:L:R25	R:R:T215	7.76	Yes	No	1	0	5
242	R:R:T216	R:R:Y298	6.24	No	No	0	5	4
243	R:R:F217	R:R:I221	11.3	No	No	0	4	4
244	R:R:I218	R:R:L222	5.71	No	Yes	0	5	6
245	L:L:F26	R:R:I218	8.79	Yes	No	0	0	5
246	R:R:L219	R:R:M294	4.24	No	Yes	0	5	5
247	R:R:I221	R:R:L222	4.28	No	Yes	0	4	6
248	R:R:F223	R:R:H290	10.18	No	Yes	0	8	7
249	R:R:L225	R:R:P226	4.93	No	No	0	5	9
250	R:R:L225	R:R:V229	2.98	No	Yes	0	5	6
251	R:R:F282	R:R:L227	4.87	No	No	0	9	6
252	R:R:M228	R:R:V229	3.04	No	Yes	0	4	6
253	R:R:L233	R:R:V229	2.98	No	Yes	0	7	6
254	R:R:M230	R:R:Y234	3.59	No	Yes	3	8	9
255	R:R:L231	R:R:S235	3	No	No	0	5	4
256	R:R:L231	R:R:V279	2.98	No	No	0	5	8
257	R:R:I232	R:R:K236	2.91	No	No	0	3	4
258	R:R:M275	R:R:Y234	15.57	Yes	Yes	3	8	9
259	R:R:V279	R:R:Y234	5.05	No	Yes	0	8	9
260	R:R:G238	R:R:I237	3.53	No	Yes	0	6	9
261	R:R:I237	R:R:L241	2.85	Yes	No	3	9	8
262	R:R:I237	R:R:M275	4.37	Yes	Yes	3	9	8
263	R:R:E240	R:R:Y239	3.37	No	No	0	5	3
264	R:R:I243	R:R:Y239	10.88	No	No	0	4	3
265	R:R:K268	R:R:W242	3.48	No	No	0	7	4
266	R:R:K269	R:R:W242	10.44	No	No	0	5	4
267	R:R:I264	R:R:K268	4.36	No	No	0	4	7
268	R:R:M274	R:R:M275	4.33	No	Yes	0	8	8
269	R:R:M274	R:R:M335	11.55	No	No	0	8	7
270	R:R:C285	R:R:L281	3.17	No	No	1	8	7
271	R:R:C327	R:R:L281	4.76	Yes	No	1	6	7
272	R:R:L281	R:R:N328	4.12	No	Yes	0	7	9
273	R:R:C285	R:R:N324	6.3	No	Yes	1	8	9
274	R:R:C285	R:R:C327	7.28	No	Yes	1	8	6
275	R:R:F289	R:R:W286	6.01	Yes	Yes	1	6	8
276	R:R:H290	R:R:W286	3.17	Yes	Yes	1	7	8
277	R:R:G321	R:R:W286	5.63	No	Yes	0	7	8
278	R:R:N324	R:R:W286	11.3	Yes	Yes	1	9	8
279	R:R:I320	R:R:P288	8.47	No	No	0	7	9
280	R:R:F289	R:R:H290	5.66	Yes	Yes	1	6	7
281	R:R:F289	R:R:H293	16.97	Yes	Yes	1	6	5
282	R:R:F289	R:R:Q318	3.51	Yes	Yes	1	6	6
283	L:L:F26	R:R:F289	5.36	Yes	Yes	0	0	6
284	R:R:I296	R:R:V292	3.07	No	No	0	4	5
285	R:R:I313	R:R:V292	4.61	No	No	0	5	5
286	R:R:V292	R:R:V317	6.41	No	No	0	5	7
287	R:R:F314	R:R:H293	6.79	No	Yes	0	5	5
288	L:L:R25	R:R:H293	4.51	Yes	Yes	1	0	5
289	R:R:M294	R:R:Y298	3.59	Yes	No	0	5	4
290	R:R:F301	R:R:I296	10.05	No	No	0	1	4
291	R:R:F314	R:R:I296	6.28	No	No	0	5	4
292	R:R:K303	R:R:N300	8.39	No	No	0	4	2
293	R:R:F301	R:R:Y305	8.25	No	No	0	1	2
294	R:R:F301	R:R:I310	3.77	No	No	0	1	4
295	R:R:E302	R:R:I310	4.1	No	No	0	2	4
296	R:R:E304	R:R:Y305	5.61	No	No	0	5	2
297	R:R:T309	R:R:Y305	6.24	No	No	0	3	2
298	R:R:D306	R:R:T309	8.67	No	No	0	1	3
299	R:R:I316	R:R:M312	2.92	No	No	0	5	1
300	R:R:F322	R:R:Q318	4.68	Yes	Yes	1	7	6
301	L:L:?27	R:R:Q318	9.88	Yes	Yes	1	0	6
302	L:L:?27	R:R:F322	3.01	Yes	Yes	1	0	7
303	R:R:C327	R:R:S323	3.44	Yes	No	0	6	5
304	R:R:C327	R:R:N324	4.72	Yes	Yes	1	6	9
305	R:R:N324	R:R:N328	12.26	Yes	Yes	0	9	9
306	R:R:I326	R:R:S325	3.1	Yes	Yes	1	7	9
307	R:R:N328	R:R:Y332	4.65	Yes	No	0	9	9
308	R:R:A333	R:R:F339	4.16	No	No	0	7	8
309	R:R:N336	R:R:N338	4.09	No	No	0	8	6
310	R:R:F339	R:R:V343	3.93	No	No	9	8	6
311	R:R:K341	R:R:N342	13.99	No	No	0	4	6
312	L:L:G3	L:L:P4	4.06	No	No	2	0	0
313	L:L:E10	L:L:N7	5.26	No	No	0	0	0
314	L:L:L12	L:L:L8	6.92	No	No	0	0	0
315	L:L:S16	L:L:Y15	6.36	No	Yes	4	0	0
316	L:L:F22	L:L:F24	4.29	Yes	Yes	1	0	0
317	L:L:?27	L:L:F24	3.01	Yes	Yes	1	0	0
318	L:L:F26	L:L:R25	12.83	Yes	Yes	0	0	0
319	L:L:?27	L:L:F26	3.01	Yes	Yes	0	0	0
320	R:R:I84	R:R:N81	2.83	No	Yes	0	8	8
321	L:L:K19	R:R:L202	2.82	No	No	0	0	4
322	R:R:G114	R:R:W111	2.81	No	Yes	0	8	8
323	R:R:L46	R:R:L50	2.77	No	No	0	4	5
324	R:R:L219	R:R:L224	2.77	No	No	0	5	4
325	R:R:A287	R:R:F223	2.77	No	No	0	6	8
326	R:R:E197	R:R:I188	2.73	No	No	0	6	3
327	R:R:H290	R:R:M294	2.63	Yes	Yes	0	7	5
328	R:R:F123	R:R:V174	2.62	No	No	0	6	4
329	R:R:E187	R:R:E204	2.54	No	No	0	1	3
330	R:R:D191	R:R:H198	2.52	No	No	0	3	1
331	R:R:V278	R:R:Y234	2.52	No	Yes	0	8	9
332	R:R:V278	R:R:Y332	2.52	No	No	0	8	9
333	R:R:F334	R:R:I330	2.51	No	No	0	6	7
334	R:R:F334	R:R:M335	2.49	No	No	0	6	7
335	R:R:M153	R:R:R161	2.48	Yes	No	0	6	5
336	R:R:F11	R:R:L193	2.44	No	No	0	7	3
337	R:R:F56	R:R:L60	2.44	Yes	No	1	6	6
338	R:R:F96	R:R:L60	2.44	No	No	1	5	6
339	R:R:M120	R:R:W181	2.33	No	No	0	4	4
340	R:R:L186	R:R:W111	2.28	No	Yes	0	5	8
341	R:R:H210	R:R:W205	2.12	No	Yes	0	4	5
342	L:L:G20	L:L:G21	2.11	No	No	0	0	0
343	R:R:G177	R:R:P179	2.03	No	No	0	7	7
344	L:L:A9	L:L:G6	1.95	No	No	0	0	0
345	R:R:A287	R:R:P288	1.87	No	No	0	6	9
346	R:R:G177	R:R:S126	1.86	No	No	0	7	3
347	R:R:G238	R:R:V272	1.84	No	No	0	6	7
348	R:R:G52	R:R:T51	1.82	Yes	No	0	6	4
349	R:R:G177	R:R:T127	1.82	No	No	0	7	5
350	R:R:P38	R:R:V308	1.77	Yes	No	0	2	3
351	R:R:P41	R:R:V308	1.77	Yes	No	0	3	3
352	R:R:G52	R:R:I99	1.76	Yes	Yes	0	6	7
353	R:R:G52	R:R:I319	1.76	Yes	No	0	6	4
354	R:R:P38	R:R:T37	1.75	Yes	No	0	2	5
355	R:R:G52	R:R:M103	1.75	Yes	Yes	0	6	7
356	R:R:G42	R:R:K45	1.74	No	No	0	3	5
357	R:R:G62	R:R:L65	1.71	No	No	0	8	7
358	R:R:A75	R:R:S73	1.71	No	No	0	6	5
359	R:R:G167	R:R:L166	1.71	No	No	0	4	7
360	L:L:G14	L:L:N13	1.7	No	No	0	0	0
361	R:R:D191	R:R:P33	1.61	No	No	0	3	6
362	R:R:V49	R:R:V53	1.6	No	No	8	4	4
363	R:R:V168	R:R:V172	1.6	No	No	0	4	5
364	R:R:V272	R:R:V276	1.6	No	No	0	7	5
365	R:R:V278	R:R:V331	1.6	No	No	0	8	8
366	R:R:T216	R:R:V220	1.59	No	No	0	5	5
367	R:R:T277	R:R:V331	1.59	No	No	0	6	8
368	R:R:A283	R:R:L227	1.58	No	No	0	6	6
369	R:R:A271	R:R:L241	1.58	No	No	0	7	8
370	R:R:I84	R:R:V66	1.54	No	No	0	8	9
371	R:R:H149	R:R:P150	1.53	Yes	No	0	6	8
372	R:R:M103	R:R:V49	1.52	Yes	No	8	7	4
373	R:R:M103	R:R:V53	1.52	Yes	No	8	7	4
374	R:R:M76	R:R:V69	1.52	Yes	Yes	0	7	7
375	R:R:I273	R:R:T277	1.52	No	No	0	6	6
376	R:R:M295	R:R:V291	1.52	No	No	0	4	6
377	R:R:I188	R:R:I199	1.47	No	No	0	3	4
378	R:R:I264	R:R:K263	1.45	No	No	0	4	3
379	R:R:I264	R:R:K267	1.45	No	No	0	4	6
380	R:R:I273	R:R:K269	1.45	No	No	0	6	5
381	R:R:P33	R:R:R32	1.44	No	No	0	6	7
382	R:R:P41	R:R:R43	1.44	Yes	No	0	3	3
383	R:R:M294	R:R:M295	1.44	Yes	No	0	5	4
384	L:L:L8	R:R:I6	1.43	No	No	0	0	4
385	R:R:E240	R:R:V148	1.43	No	No	0	5	7
386	R:R:L104	R:R:M103	1.41	No	Yes	0	4	7
387	R:R:M274	R:R:N336	1.4	No	No	0	8	8
388	R:R:K341	R:R:N338	1.4	No	No	0	4	6
389	R:R:H210	R:R:S207	1.39	No	No	0	4	6
390	R:R:L20	R:R:L28	1.38	No	No	2	5	5
391	L:L:L5	R:R:L28	1.38	Yes	No	2	0	5
392	R:R:H182	R:R:V183	1.38	No	Yes	0	4	5
393	R:R:L112	R:R:N110	1.37	No	No	0	2	5
394	R:R:E337	R:R:K267	1.35	No	No	0	5	6
395	R:R:R160	R:R:T158	1.29	No	No	0	5	7
396	R:R:R160	R:R:T164	1.29	No	No	0	5	2
397	R:R:M335	R:R:R270	1.24	No	No	0	7	7
398	R:R:F192	R:R:L34	1.22	No	Yes	0	3	5
399	R:R:K196	R:R:Y194	1.19	No	No	0	3	1
400	R:R:E9	R:R:R13	1.16	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H18	10.1275	4	2	8
2	R:R:F25	8.3525	4	2	7
3	R:R:Y29	11.004	5	2	8
4	R:R:L34	2.9525	4	4	5
5	R:R:P38	3.186	5	7	2
6	R:R:P41	3.025	4	0	3
7	R:R:G52	1.7725	4	0	6
8	R:R:F56	4.0625	4	1	6
9	R:R:N63	6.8075	4	1	9
10	R:R:F67	4.8275	4	0	7
11	R:R:V69	4.8775	4	9	7
12	R:R:M76	6.0875	4	0	7
13	R:R:N81	4.3125	4	0	8
14	R:R:F83	6.3775	4	0	7
15	R:R:L87	4.7875	4	0	9
16	R:R:D91	8.9125	4	1	9
17	R:R:I94	4.925	4	0	7
18	R:R:I99	3.7	4	0	7
19	R:R:T102	5.0375	4	1	6
20	R:R:M103	1.55	4	8	7
21	R:R:W111	6.4075	8	1	8
22	R:R:V121	4.32	4	1	5
23	R:R:P122	6.6825	4	1	5
24	R:R:Q125	5.3225	4	1	7
25	R:R:V129	4.114	5	1	7
26	R:R:V130	4.6575	4	0	6
27	R:R:E132	5.446	5	1	9
28	R:R:I133	5.01	4	1	7
29	R:R:M136	4.948	5	0	8
30	R:R:E142	9.3725	4	5	8
31	R:R:H149	6.315	4	11	6
32	R:R:M153	3.71	4	0	6
33	R:R:Y157	9.3225	4	5	6
34	R:R:M180	5.74	4	0	5
35	R:R:V183	7.74	4	1	5
36	R:R:Q184	7.23	5	1	5
37	R:R:E203	7.26	5	1	5
38	R:R:W205	13.406	5	1	5
39	R:R:Y214	10.8525	4	0	6
40	R:R:L222	5.796	5	1	6
41	R:R:V229	3.0425	4	0	6
42	R:R:Y234	7.23167	6	3	9
43	R:R:I237	3.7575	4	3	9
44	R:R:M275	7.3075	4	3	8
45	R:R:W286	5.71333	6	1	8
46	R:R:F289	7.502	5	1	6
47	R:R:H290	5.41	4	1	7
48	R:R:H293	8.095	4	1	5
49	R:R:M294	2.975	4	0	5
50	R:R:Q318	6.29	4	1	6
51	R:R:F322	4.678	5	1	7
52	R:R:N324	8.23	5	1	9
53	R:R:S325	3.535	4	1	9
54	R:R:I326	3.405	4	1	7
55	R:R:C327	5.05	4	1	6
56	R:R:N328	7.7125	4	0	9
57	L:L:L5	8.34	5	2	0
58	L:L:Y15	5.3875	4	4	0
59	L:L:F22	6.99	4	1	0
60	L:L:F24	6.90429	7	1	0
61	L:L:R25	7.795	6	1	0
62	L:L:F26	7.19167	6	0	0
63	L:L:?27	4.85833	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L8	R:R:I6	24.1979	1.43	No	No	0	0	4
2	L:L:L8	R:R:Y29	13.7932	10.55	No	Yes	0	0	8
3	R:R:L31	R:R:Y29	40.4223	8.21	No	Yes	0	6	8
4	L:L:N13	R:R:L31	56.7478	5.49	No	No	0	0	6
5	L:L:N13	R:R:R32	59.5777	6.03	No	No	0	0	7
6	R:R:P33	R:R:R32	62.3955	1.44	No	No	0	6	7
7	R:R:D191	R:R:P33	63.7943	1.61	No	No	0	3	6
8	R:R:D191	R:R:L34	13.8378	4.07	No	Yes	0	3	5
9	L:L:L12	L:L:L8	13.4896	6.92	No	No	0	0	0
10	L:L:L12	R:R:L31	14.9653	4.15	No	No	0	0	6
11	R:R:I6	R:R:Q10	15.2102	6.86	No	No	0	4	7
12	R:R:Q10	R:R:T7	12.1759	11.34	No	No	0	7	5
13	L:L:L5	R:R:Y29	16.7871	9.38	Yes	Yes	2	0	8
14	R:R:D191	R:R:H198	77.4579	2.52	No	No	0	3	1
15	R:R:H198	R:R:V35	82.8182	11.07	No	No	0	1	5
16	L:L:K18	R:R:V35	84.1582	3.04	No	No	0	0	5
17	L:L:K18	R:R:K189	85.4942	2.87	No	No	0	0	1
18	R:R:C200	R:R:K189	90.7978	6.47	No	No	0	4	1
19	L:L:G20	R:R:C200	92.1135	3.92	No	No	0	0	4
20	L:L:G20	L:L:G21	93.4252	2.11	No	No	0	0	0
21	L:L:G21	R:R:D109	94.7329	3.35	No	No	0	0	4
22	R:R:D109	R:R:T37	96.0365	10.12	No	No	0	4	5
23	R:R:P38	R:R:T37	97.3361	1.75	Yes	No	0	2	5
24	L:L:K19	R:R:P38	96.0082	5.02	No	Yes	0	0	2
25	R:R:K311	R:R:L40	10.0545	15.51	No	No	0	2	3
26	R:R:K311	R:R:N106	10.7063	4.2	No	No	0	2	5
27	R:R:N106	R:R:T102	12.6556	2.92	No	Yes	0	5	6
28	R:R:F322	R:R:I99	15.5705	5.02	Yes	Yes	0	7	7
29	R:R:G52	R:R:I99	10.3743	1.76	Yes	Yes	0	6	7
30	L:L:K19	R:R:L202	97.33	2.82	No	No	0	0	4
31	L:L:S23	R:R:L202	98.662	4.5	No	No	0	0	4
32	L:L:S23	R:R:E203	100	10.06	No	Yes	0	0	5
33	L:L:R25	R:R:E203	97.664	5.82	Yes	Yes	1	0	5
34	L:L:R25	R:R:H293	28.2585	4.51	Yes	Yes	1	0	5
35	R:R:F289	R:R:H293	30.8374	16.97	Yes	Yes	1	6	5
36	R:R:F289	R:R:W286	56.0029	6.01	Yes	Yes	1	6	8
37	R:R:E132	R:R:W286	66.5371	3.27	Yes	Yes	1	9	8
38	R:R:D91	R:R:E132	48.4747	6.5	Yes	Yes	1	9	9
39	L:L:F26	L:L:R25	81.0085	12.83	Yes	Yes	0	0	0
40	L:L:F26	R:R:F289	33.1491	5.36	Yes	Yes	0	0	6
41	L:L:F26	R:R:V129	77.2515	6.55	Yes	Yes	0	0	7
42	R:R:V129	R:R:W286	32.556	4.9	Yes	Yes	1	7	8
43	R:R:I94	R:R:V129	26.2059	3.07	Yes	Yes	0	7	7
44	R:R:E132	R:R:I94	40.0296	6.83	Yes	Yes	0	9	7
45	R:R:D91	R:R:N63	40.0883	13.46	Yes	Yes	1	9	9
46	R:R:A88	R:R:N63	33.3941	3.13	No	Yes	0	9	9
47	R:R:A88	R:R:V66	29.3921	3.39	No	No	0	9	9
48	R:R:I84	R:R:V66	27.5339	1.54	No	No	0	8	9
49	R:R:I84	R:R:N81	25.706	2.83	No	Yes	0	8	8
50	R:R:M76	R:R:N81	18.8964	5.61	Yes	Yes	0	7	8
51	R:R:M76	R:R:V69	12.7649	1.52	Yes	Yes	0	7	7
52	R:R:W205	R:R:Y214	11.7184	5.79	Yes	Yes	0	5	6
53	R:R:I218	R:R:Y214	13.3661	13.3	No	Yes	0	5	6
54	R:R:I218	R:R:L222	16.5321	5.71	No	Yes	0	5	6
55	R:R:L222	R:R:V130	18.2527	7.45	Yes	Yes	0	6	6
56	R:R:E132	R:R:M136	67.0412	4.06	Yes	Yes	0	9	8
57	R:R:L87	R:R:M136	41.5457	4.24	Yes	Yes	0	9	8
58	R:R:I139	R:R:L87	33.5641	2.85	No	Yes	0	8	9
59	R:R:F83	R:R:I139	32.6633	5.02	Yes	No	0	7	8
60	R:R:E142	R:R:F83	25.1574	8.16	Yes	Yes	0	8	7
61	R:R:I133	R:R:V129	33.1592	3.07	Yes	Yes	1	7	7
62	R:R:F282	R:R:I133	20.6271	5.02	No	Yes	0	9	7
63	R:R:F282	R:R:M136	19.9955	3.73	No	Yes	0	9	8
64	R:R:E142	R:R:Y157	12.8034	12.35	Yes	Yes	5	8	6
65	R:R:N324	R:R:W286	18.9976	11.3	Yes	Yes	1	9	8
66	R:R:N324	R:R:N328	16.0361	12.26	Yes	Yes	0	9	9
67	R:R:N328	R:R:Y332	16.1677	4.65	Yes	No	0	9	9
68	R:R:E203	R:R:Q184	14.7791	3.82	Yes	Yes	1	5	5
69	L:L:?27	L:L:F24	34.5033	3.01	Yes	Yes	1	0	0
70	L:L:?27	L:L:F26	29.6229	3.01	Yes	Yes	0	0	0
71	L:L:F24	R:R:W111	23.289	5.01	Yes	Yes	1	0	8
72	R:R:L186	R:R:W111	12.2548	2.28	No	Yes	0	5	8
73	L:L:F26	R:R:S126	10.9917	6.61	Yes	No	0	0	3
74	R:R:I133	R:R:P226	25.708	3.39	Yes	No	0	7	9
75	R:R:M136	R:R:M230	38.983	2.89	Yes	No	0	8	8
76	R:R:P226	R:R:T137	12.4147	3.5	No	No	0	9	7
77	R:R:T137	R:R:V229	11.5038	3.17	No	Yes	0	7	6
78	R:R:L225	R:R:P226	12.4147	4.93	No	No	0	5	9
79	R:R:L225	R:R:V229	11.5038	2.98	No	Yes	0	5	6
80	R:R:M230	R:R:Y234	35.7361	3.59	No	Yes	3	8	9
81	R:R:L233	R:R:V229	19.2972	2.98	No	Yes	0	7	6
82	R:R:M275	R:R:Y234	27.3496	15.57	Yes	Yes	3	8	9
83	R:R:H144	R:R:L233	15.6495	15.43	No	No	0	7	7
84	R:R:H144	R:R:V148	10.3419	9.69	No	No	0	7	7
85	R:R:M153	R:R:Y157	11.3459	4.79	Yes	Yes	0	6	6
86	R:R:I237	R:R:M275	12.8216	4.37	Yes	Yes	3	9	8
87	R:R:H210	R:R:W205	13.9653	2.12	No	Yes	0	4	5
88	R:R:V278	R:R:Y332	16.7851	2.52	No	No	0	8	9
89	R:R:V278	R:R:V331	17.5179	1.6	No	No	0	8	8
90	R:R:T277	R:R:V331	15.7932	1.59	No	No	0	6	8
91	R:R:I273	R:R:T277	14.0544	1.52	No	No	0	6	6
92	R:R:I273	R:R:K269	12.3115	1.45	No	No	0	6	5
93	R:R:K269	R:R:W242	10.5646	10.44	No	No	0	5	4
94	R:R:M274	R:R:M275	15.6535	4.33	No	Yes	0	8	8
95	R:R:F314	R:R:H293	14.8884	6.79	No	Yes	0	5	5
96	R:R:F314	R:R:I296	13.6698	6.28	No	No	0	5	4
97	L:L:?27	R:R:F322	10.605	3.01	Yes	Yes	1	0	7
98	R:R:C98	R:R:Q125	11.5362	6.1	No	Yes	0	7	7
99	R:R:C98	R:R:I94	20.4854	6.55	No	Yes	0	7	7
100	R:R:F289	R:R:Q318	11.1658	3.51	Yes	Yes	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:A3	R:R:I6	3.25	0	No	No	4	4	1	1
L:L:E11	R:R:A3	4.53	0	No	No	0	4	0	1
R:R:L4	R:R:N5	8.24	4	No	No	4	7	1	1
L:L:Y15	R:R:L4	4.69	4	Yes	No	0	4	0	1
L:L:Y15	R:R:N5	6.98	4	Yes	No	0	7	0	1
R:R:I6	R:R:Q10	6.86	0	No	No	4	7	1	2
R:R:F11	R:R:L15	12.18	2	No	No	7	7	2	2
R:R:F11	R:R:F25	8.57	2	No	Yes	7	7	2	1
R:R:F25	R:R:L15	3.65	2	Yes	No	7	7	1	2
R:R:D17	R:R:H18	5.04	0	No	Yes	8	8	2	1
L:L:G3	R:R:H18	3.18	2	No	Yes	0	8	0	1
L:L:P4	R:R:H18	9.15	2	No	Yes	0	8	0	1
L:L:L5	R:R:H18	23.14	2	Yes	Yes	0	8	0	1
R:R:L20	R:R:Q24	5.32	2	No	No	5	8	1	2
L:L:L5	R:R:L20	4.15	2	Yes	No	0	5	0	1
R:R:F25	R:R:Y29	17.54	2	Yes	Yes	7	8	1	1
L:L:L5	R:R:F25	3.65	2	Yes	Yes	0	7	0	1
R:R:L31	R:R:Y29	8.21	0	No	Yes	6	8	1	1
L:L:L5	R:R:Y29	9.38	2	Yes	Yes	0	8	0	1
L:L:L8	R:R:Y29	10.55	0	No	Yes	0	8	0	1
L:L:A9	R:R:Y29	9.34	0	No	Yes	0	8	0	1
L:L:L12	R:R:L31	4.15	0	No	No	0	6	0	1
L:L:N13	R:R:L31	5.49	0	No	No	0	6	0	1
L:L:N13	R:R:R32	6.03	0	No	No	0	7	0	1
L:L:R17	R:R:R32	10.66	0	No	No	0	7	0	1
R:R:D191	R:R:L34	4.07	0	No	Yes	3	5	2	1
L:L:Y15	R:R:L34	3.52	4	Yes	Yes	0	5	0	1
L:L:S16	R:R:L34	3	4	No	Yes	0	5	0	1
R:R:H198	R:R:V35	11.07	0	No	No	1	5	2	1
L:L:K18	R:R:V35	3.04	0	No	No	0	5	0	1
R:R:P38	R:R:Y36	4.17	7	Yes	No	2	4	1	2
R:R:D307	R:R:Y36	4.6	7	No	No	2	4	2	2
R:R:D109	R:R:T37	10.12	0	No	No	4	5	1	2
R:R:D307	R:R:P38	3.22	7	No	Yes	2	2	2	1
L:L:K19	R:R:P38	5.02	0	No	Yes	0	2	0	1
R:R:C98	R:R:I94	6.55	0	No	Yes	7	7	2	2
R:R:I94	R:R:V129	3.07	0	Yes	Yes	7	7	2	1
R:R:C98	R:R:Q125	6.1	0	No	Yes	7	7	2	1
R:R:C98	R:R:F322	4.19	0	No	Yes	7	7	2	1
R:R:F322	R:R:I99	5.02	1	Yes	Yes	7	7	1	2
R:R:V101	R:R:V121	6.41	1	No	Yes	5	5	1	2
R:R:Q125	R:R:V101	4.3	1	Yes	No	7	5	1	1
L:L:F24	R:R:V101	6.55	1	Yes	No	0	5	0	1
R:R:N106	R:R:T102	2.92	0	No	Yes	5	6	2	1
R:R:Q318	R:R:T102	7.09	1	Yes	Yes	6	6	1	1
R:R:F322	R:R:T102	6.49	1	Yes	Yes	7	6	1	1
L:L:?27	R:R:T102	3.65	1	Yes	Yes	0	6	0	1
L:L:F22	R:R:Q105	4.68	1	Yes	No	0	5	0	1
L:L:F24	R:R:Q105	11.71	1	Yes	No	0	5	0	1
R:R:N110	R:R:S108	2.98	0	No	No	5	5	2	1
L:L:F22	R:R:S108	3.96	1	Yes	No	0	5	0	1
L:L:G21	R:R:D109	3.35	0	No	No	0	4	0	1
R:R:G113	R:R:W111	5.63	1	No	Yes	7	8	2	1
R:R:I117	R:R:W111	3.52	1	No	Yes	6	8	2	1
R:R:C118	R:R:W111	3.92	1	No	Yes	9	8	2	1
R:R:C201	R:R:W111	13.06	1	No	Yes	9	8	2	1
L:L:F22	R:R:W111	15.03	1	Yes	Yes	0	8	0	1
L:L:F24	R:R:W111	5.01	1	Yes	Yes	0	8	0	1
R:R:G113	R:R:I117	3.53	1	No	No	7	6	2	2
R:R:C118	R:R:Q184	4.58	1	No	Yes	9	5	2	1
R:R:C118	R:R:C201	7.28	1	No	No	9	9	2	2
R:R:P122	R:R:V121	3.53	1	Yes	Yes	5	5	1	2
R:R:Q125	R:R:V121	4.3	1	Yes	Yes	7	5	1	2
R:R:M180	R:R:P122	3.35	0	Yes	Yes	5	5	2	1
R:R:P122	R:R:Q184	12.63	1	Yes	Yes	5	5	1	1
L:L:F24	R:R:P122	7.22	1	Yes	Yes	0	5	0	1
L:L:?27	R:R:Q125	6.59	1	Yes	Yes	0	7	0	1
R:R:M180	R:R:S126	4.6	0	Yes	No	5	3	2	1
L:L:F26	R:R:S126	6.61	0	Yes	No	0	3	0	1
R:R:I133	R:R:V129	3.07	1	Yes	Yes	7	7	2	1
R:R:L222	R:R:V129	2.98	1	Yes	Yes	6	7	2	1
R:R:V129	R:R:W286	4.9	1	Yes	Yes	7	8	1	2
L:L:F26	R:R:V129	6.55	0	Yes	Yes	0	7	0	1
R:R:I133	R:R:L222	8.56	1	Yes	Yes	7	6	2	2
R:R:M180	R:R:V183	3.04	0	Yes	Yes	5	5	2	2
R:R:M180	R:R:Y214	11.97	0	Yes	Yes	5	6	2	1
R:R:E203	R:R:V183	5.7	1	Yes	Yes	5	5	1	2
R:R:V183	R:R:W205	20.84	1	Yes	Yes	5	5	2	2
R:R:C201	R:R:Q184	4.58	1	No	Yes	9	5	2	1
R:R:E203	R:R:Q184	3.82	1	Yes	Yes	5	5	1	1
L:L:F24	R:R:Q184	10.54	1	Yes	Yes	0	5	0	1
R:R:E187	R:R:K189	5.4	0	No	No	1	1	2	1
R:R:C200	R:R:K189	6.47	0	No	No	4	1	1	1
L:L:K18	R:R:K189	2.87	0	No	No	0	1	0	1
L:L:G20	R:R:C200	3.92	0	No	No	0	4	0	1
L:L:S23	R:R:L202	4.5	0	No	No	0	4	0	1
R:R:E203	R:R:W205	10.9	1	Yes	Yes	5	5	1	2
L:L:S23	R:R:E203	10.06	0	No	Yes	0	5	0	1
L:L:R25	R:R:E203	5.82	1	Yes	Yes	0	5	0	1
R:R:Q211	R:R:W205	27.38	0	No	Yes	4	5	1	2
R:R:W205	R:R:Y214	5.79	1	Yes	Yes	5	6	2	1
R:R:E297	R:R:Q211	14.02	0	No	No	5	4	2	1
L:L:R25	R:R:Q211	3.5	1	Yes	No	0	4	0	1
R:R:I218	R:R:Y214	13.3	0	No	Yes	5	6	1	1
L:L:R25	R:R:Y214	12.35	1	Yes	Yes	0	6	0	1
R:R:H293	R:R:T215	4.11	1	Yes	No	5	5	1	1
R:R:E297	R:R:T215	7.06	0	No	No	5	5	2	1
L:L:R25	R:R:T215	7.76	1	Yes	No	0	5	0	1
R:R:I218	R:R:L222	5.71	0	No	Yes	5	6	1	2
L:L:F26	R:R:I218	8.79	0	Yes	No	0	5	0	1
R:R:F289	R:R:W286	6.01	1	Yes	Yes	6	8	1	2
R:R:H290	R:R:W286	3.17	1	Yes	Yes	7	8	2	2
R:R:F289	R:R:H290	5.66	1	Yes	Yes	6	7	1	2
R:R:F289	R:R:H293	16.97	1	Yes	Yes	6	5	1	1
R:R:F289	R:R:Q318	3.51	1	Yes	Yes	6	6	1	1
L:L:F26	R:R:F289	5.36	0	Yes	Yes	0	6	0	1
R:R:F314	R:R:H293	6.79	0	No	Yes	5	5	2	1
L:L:R25	R:R:H293	4.51	1	Yes	Yes	0	5	0	1
R:R:F322	R:R:Q318	4.68	1	Yes	Yes	7	6	1	1
L:L:?27	R:R:Q318	9.88	1	Yes	Yes	0	6	0	1
L:L:?27	R:R:F322	3.01	1	Yes	Yes	0	7	0	1
L:L:K19	R:R:L202	2.82	0	No	No	0	4	0	1
R:R:G114	R:R:W111	2.81	0	No	Yes	8	8	2	1
R:R:D191	R:R:H198	2.52	0	No	No	3	1	2	2
R:R:L186	R:R:W111	2.28	0	No	Yes	5	8	2	1
R:R:G177	R:R:S126	1.86	0	No	No	7	3	2	1
R:R:P38	R:R:V308	1.77	7	Yes	No	2	3	1	2
R:R:P38	R:R:T37	1.75	7	Yes	No	2	5	1	2
R:R:D191	R:R:P33	1.61	0	No	No	3	6	2	2
R:R:P33	R:R:R32	1.44	0	No	No	6	7	2	1
L:L:L8	R:R:I6	1.43	0	No	No	0	4	0	1
R:R:L20	R:R:L28	1.38	2	No	No	5	5	1	1
L:L:L5	R:R:L28	1.38	2	Yes	No	0	5	0	1
R:R:F192	R:R:L34	1.22	0	No	Yes	3	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZH8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	334
Number of Links	400
Number of Hubs	63
Number of Links mediated by Hubs	211
Number of Communities	11
Number of Nodes involved in Communities	92
Number of Links involved in Communities	124

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	132322
Length Of Smallest Path	3
Average Path Length	17.5277
Length of Longest Path	43
Minimum Path Strength	1.29
Average Path Strength	5.44196
Maximum Path Strength	24.11
Minimum Path Correlation	0.7
Average Path Correlation	0.956846
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	62.3612
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.8014
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • ionotropic glutamate receptor binding • glutamate receptor binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • insulin-like growth factor receptor binding • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • apoptotic signaling pathway • negative regulation of apoptotic process • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • response to nutrient levels • response to nutrient • skeletal system development • bone development • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • developmental growth • growth • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • fibroblast proliferation • midbody • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • neuronal dense core vesicle • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • ciliary basal body • apical part of cell • apical plasma membrane • molecular transducer activity • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • orexigenic neuropeptide QRFP receptor binding • neuropeptide signaling pathway • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • blood circulation • behavior • locomotory behavior • regulation of behavior • feeding behavior • regulation of feeding behavior • grooming behavior
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?27
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96P65
Sequence	>8ZH8_nogp_Chain_R A L N I T P E Q F S R L L R D H N L T R E Q F I A L Y R L R P L V Y T P E L P G R A K L A L V L T G V L I F A L A L F G N A L V F Y V V T R S K A M R T V T N I F I C S L A L S D L L I T F F C I P V T M L Q N I S D N W L G G A F I C K M V P F V Q S T A V V T E I L T M T C I A V E R H Q G L V H P F K M K W Q Y T N R R A F T M L G V V W L V A V I V G S P M W H V Q Q L E I K Y D F L Y E K E H I C C L E E W T S P V H Q K I Y T T F I L V I L F L L P L M V M L I L Y S K I G Y E L W I K I A R K K K R A V I M M V T V V A L F A V C W A P F H V V H M M I E Y S N F E K E Y D D V T I K M I F A I V Q I I G F S N S I C N P I V Y A F M N E N F K K N V L S A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZH8	A	Peptide	P518	QRFP	Homo sapiens	QRF-Amide	-	Gq/β1/γ1	3.19	2024-07-03	10.1038/s41467-024-49030-5
	8ZH8 (No Gprot)	A	Peptide	P518	QRFP	Homo sapiens	QRF-Amide	-		3.19	2024-07-03	10.1038/s41467-024-49030-5
	8WZ2	A	Peptide	P518	QRFP	Homo sapiens	Orexigenic Neuropeptide QRFP	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.73	2024-06-19	10.1038/s41421-024-00670-3
	8WZ2 (No Gprot)	A	Peptide	P518	QRFP	Homo sapiens	Orexigenic Neuropeptide QRFP	-		2.73	2024-06-19	10.1038/s41421-024-00670-3

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