psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V133	3.96	Yes	No	0	0	6
2	L:L:?1	R:R:L223	6.44	Yes	No	0	0	5
3	L:L:?1	R:R:M224	5.64	Yes	No	0	0	5
4	L:L:?1	R:R:C228	7.39	Yes	No	0	0	7
5	L:L:?1	R:R:W281	6.06	Yes	Yes	2	0	8
6	L:L:?1	R:R:Y284	16.37	Yes	No	2	0	7
7	L:L:?1	R:R:A288	3.14	Yes	No	0	0	5
8	L:L:?1	R:R:A311	4.19	Yes	No	2	0	7
9	L:L:?1	R:R:K312	10.31	Yes	No	0	0	7
10	R:R:G38	R:R:P39	4.06	No	Yes	0	5	8
11	R:R:F40	R:R:P39	5.78	Yes	Yes	0	4	8
12	R:R:P196	R:R:P39	13.64	No	Yes	6	3	8
13	R:R:K200	R:R:P39	10.04	No	Yes	6	3	8
14	R:R:F119	R:R:F40	4.29	Yes	Yes	0	7	4
15	R:R:F40	R:R:G122	3.01	Yes	No	0	4	8
16	R:R:F40	R:R:H123	5.66	Yes	No	0	4	2
17	R:R:G42	R:R:P43	4.06	No	No	8	3	6
18	R:R:G42	R:R:Y118	8.69	No	No	8	3	5
19	R:R:P43	R:R:Y45	9.74	No	No	0	6	3
20	R:R:P43	R:R:Y118	6.95	No	No	8	6	5
21	R:R:R50	R:R:Y45	8.23	No	No	0	1	3
22	R:R:I47	R:R:P301	5.08	No	No	0	2	3
23	R:R:A48	R:R:Y53	4	No	Yes	0	3	4
24	R:R:P49	R:R:V52	5.3	No	No	0	4	3
25	R:R:R50	R:R:Y53	3.09	No	Yes	0	1	4
26	R:R:V52	R:R:W51	8.58	No	No	0	3	2
27	R:R:L55	R:R:W51	5.69	No	No	0	3	2
28	R:R:L199	R:R:Y53	5.86	No	Yes	0	4	4
29	R:R:H54	R:R:V58	4.15	No	No	0	4	5
30	R:R:T56	R:R:W59	4.85	No	No	0	4	4
31	R:R:L199	R:R:T56	4.42	No	No	0	4	4
32	R:R:Q114	R:R:S57	12.99	No	No	0	5	6
33	R:R:V63	R:R:W59	4.9	No	No	0	7	4
34	R:R:F309	R:R:W59	14.03	No	No	0	5	4
35	R:R:M60	R:R:S107	7.67	No	No	0	7	7
36	R:R:M60	R:R:S110	7.67	No	No	0	7	6
37	R:R:M60	R:R:V111	4.56	No	No	0	7	6
38	R:R:S107	R:R:V64	6.46	No	No	0	7	5
39	R:R:A66	R:R:I316	3.25	No	No	0	4	7
40	R:R:S67	R:R:T103	9.59	No	No	1	8	6
41	R:R:S67	R:R:T315	4.8	No	Yes	1	8	8
42	R:R:L100	R:R:V68	2.98	No	No	0	7	6
43	R:R:N71	R:R:T70	4.39	Yes	No	1	9	8
44	R:R:P319	R:R:T70	10.49	No	No	1	9	8
45	R:R:D99	R:R:N71	10.77	Yes	Yes	1	9	9
46	R:R:N71	R:R:P319	13.03	Yes	No	1	9	9
47	R:R:G72	R:R:L75	5.13	No	No	0	4	8
48	R:R:F324	R:R:L73	3.65	No	No	0	6	6
49	R:R:A96	R:R:V74	3.39	No	No	0	9	9
50	R:R:V323	R:R:V74	11.22	Yes	No	0	7	9
51	R:R:A96	R:R:L75	3.15	No	No	0	9	8
52	R:R:T78	R:R:V93	4.76	No	No	0	7	6
53	R:R:F81	R:R:K80	9.93	No	No	0	5	6
54	R:R:C332	R:R:F81	15.36	No	No	0	6	5
55	R:R:F81	R:R:Q335	14.05	No	No	0	5	5
56	R:R:K82	R:R:R85	3.71	No	No	0	6	8
57	R:R:F329	R:R:L84	10.96	Yes	No	0	8	7
58	R:R:C332	R:R:L84	6.35	No	No	0	6	7
59	R:R:H86	R:R:P87	12.2	No	No	0	8	6
60	R:R:H86	R:R:L88	7.71	No	No	0	8	8
61	R:R:P87	R:R:W90	6.76	No	No	0	6	5
62	R:R:L88	R:R:V154	5.96	No	No	0	8	8
63	R:R:F164	R:R:L88	6.09	Yes	No	0	6	8
64	R:R:L92	R:R:N89	5.49	No	No	0	8	9
65	R:R:F329	R:R:N89	8.46	Yes	No	0	8	9
66	R:R:I91	R:R:N94	4.25	Yes	Yes	1	7	9
67	R:R:I91	R:R:S143	6.19	Yes	Yes	1	7	8
68	R:R:I146	R:R:I91	5.89	Yes	Yes	1	7	7
69	R:R:I147	R:R:I91	7.36	No	Yes	1	9	7
70	R:R:E150	R:R:I91	6.83	No	Yes	1	8	7
71	R:R:L92	R:R:V323	5.96	No	Yes	0	8	7
72	R:R:N94	R:R:S143	5.96	Yes	Yes	1	9	8
73	R:R:I173	R:R:N94	8.5	No	Yes	0	7	9
74	R:R:N94	R:R:S176	4.47	Yes	Yes	1	9	7
75	R:R:N94	R:R:W177	10.17	Yes	Yes	1	9	9
76	R:R:D99	R:R:L95	8.14	Yes	No	1	9	9
77	R:R:L144	R:R:L95	4.15	No	No	1	8	9
78	R:R:L95	R:R:N318	5.49	No	Yes	1	9	9
79	R:R:D99	R:R:T315	10.12	Yes	Yes	1	9	8
80	R:R:D99	R:R:N318	5.39	Yes	Yes	1	9	9
81	R:R:E102	R:R:G137	3.27	No	No	0	7	7
82	R:R:E102	R:R:T315	5.64	No	Yes	0	7	8
83	R:R:T103	R:R:T315	9.42	No	Yes	1	6	8
84	R:R:I105	R:R:T132	9.12	No	No	0	5	4
85	R:R:A106	R:R:V133	5.09	No	No	0	6	6
86	R:R:I109	R:R:M125	5.83	No	No	0	5	6
87	R:R:I109	R:R:Q129	12.35	No	No	0	5	5
88	R:R:L121	R:R:V112	4.47	Yes	No	0	6	5
89	R:R:F119	R:R:N113	20.54	Yes	No	0	7	6
90	R:R:L121	R:R:N113	8.24	Yes	No	0	6	6
91	R:R:Q114	R:R:V115	7.16	No	No	0	5	5
92	R:R:V120	R:R:Y116	16.4	No	No	0	3	4
93	R:R:V120	R:R:Y118	8.83	No	No	0	3	5
94	R:R:C126	R:R:F119	5.59	No	Yes	7	9	7
95	R:R:F119	R:R:Q129	4.68	Yes	No	0	7	5
96	R:R:C203	R:R:F119	8.38	No	Yes	7	9	7
97	R:R:L121	R:R:V120	2.98	Yes	No	0	6	3
98	R:R:L121	R:R:M125	8.48	Yes	No	0	6	6
99	R:R:G122	R:R:P124	4.06	No	No	0	8	1
100	R:R:H123	R:R:R193	7.9	No	No	0	2	4
101	R:R:H123	R:R:W195	8.46	No	No	0	2	3
102	R:R:C126	R:R:C203	7.28	No	No	7	9	9
103	R:R:I188	R:R:V127	3.07	No	No	0	6	6
104	R:R:Q129	R:R:S202	4.33	No	No	0	5	5
105	R:R:G130	R:R:Y194	4.35	No	Yes	0	4	4
106	R:R:L135	R:R:Y131	3.52	No	Yes	0	5	6
107	R:R:T184	R:R:Y131	9.99	No	Yes	0	7	6
108	R:R:A185	R:R:Y131	4	No	Yes	0	3	6
109	R:R:I188	R:R:Y131	8.46	No	Yes	0	6	6
110	R:R:Y131	R:R:Y194	6.95	Yes	Yes	0	6	4
111	R:R:S134	R:R:T184	4.8	No	No	0	3	7
112	R:R:S134	R:R:Y194	3.82	No	Yes	0	3	4
113	R:R:I138	R:R:L141	4.28	No	Yes	0	6	7
114	R:R:A180	R:R:I138	3.25	No	No	0	8	6
115	R:R:C227	R:R:I138	8.18	Yes	No	0	6	6
116	R:R:G140	R:R:T139	3.64	No	No	0	9	7
117	R:R:T139	R:R:W177	16.98	No	Yes	0	7	9
118	R:R:G140	R:R:S143	3.71	No	Yes	0	9	8
119	R:R:L141	R:R:P231	3.28	Yes	No	0	7	9
120	R:R:F277	R:R:L141	3.65	Yes	Yes	2	9	7
121	R:R:L141	R:R:W281	4.56	Yes	Yes	2	7	8
122	R:R:F175	R:R:W142	7.02	No	Yes	3	3	5
123	R:R:W142	R:R:W179	14.99	Yes	Yes	3	5	4
124	R:R:C227	R:R:W142	5.22	Yes	Yes	3	6	5
125	R:R:P231	R:R:W142	13.51	No	Yes	0	9	5
126	R:R:S143	R:R:S176	3.26	Yes	Yes	1	8	7
127	R:R:L144	R:R:N318	5.49	No	Yes	1	8	9
128	R:R:L144	R:R:Y322	12.89	No	Yes	1	8	9
129	R:R:A145	R:R:I234	3.25	No	No	0	7	5
130	R:R:E150	R:R:I146	4.1	No	Yes	1	8	7
131	R:R:I146	R:R:S176	3.1	Yes	Yes	1	7	7
132	R:R:I147	R:R:R151	7.52	No	No	1	9	9
133	R:R:I147	R:R:Y322	6.04	No	Yes	1	9	9
134	R:R:I235	R:R:S148	6.19	No	No	0	8	8
135	R:R:C238	R:R:S148	5.16	No	No	0	7	8
136	R:R:S148	R:R:Y239	8.9	No	Yes	0	8	9
137	R:R:W149	R:R:W152	3.75	No	Yes	0	6	8
138	R:R:M153	R:R:W149	6.98	Yes	No	0	5	6
139	R:R:E150	R:R:F164	16.32	No	Yes	0	8	6
140	R:R:R151	R:R:Y239	10.29	No	Yes	0	9	9
141	R:R:R151	R:R:Y322	5.14	No	Yes	1	9	9
142	R:R:C156	R:R:W152	5.22	No	Yes	0	7	8
143	R:R:P158	R:R:W152	14.86	No	Yes	4	7	8
144	R:R:F159	R:R:W152	4.01	Yes	Yes	4	5	8
145	R:R:C238	R:R:W152	7.84	No	Yes	0	7	8
146	R:R:Q241	R:R:W152	4.38	No	Yes	0	4	8
147	R:R:M153	R:R:P158	5.03	Yes	No	4	5	7
148	R:R:F159	R:R:M153	4.98	Yes	Yes	4	5	5
149	R:R:F164	R:R:M153	3.73	Yes	Yes	0	6	5
150	R:R:V155	R:R:V242	4.81	No	No	0	8	8
151	R:R:F159	R:R:P158	13	Yes	No	4	5	7
152	R:R:F159	R:R:V162	3.93	Yes	No	0	5	4
153	R:R:G160	R:R:R163	3	No	No	0	4	4
154	R:R:D165	R:R:K167	8.3	No	No	0	7	4
155	R:R:F175	R:R:W179	13.03	No	Yes	3	3	4
156	R:R:S176	R:R:W177	3.71	Yes	Yes	1	7	9
157	R:R:W179	R:R:W183	17.81	Yes	Yes	3	4	5
158	R:R:T226	R:R:W179	3.64	No	Yes	3	4	4
159	R:R:V222	R:R:W183	3.68	No	Yes	0	5	5
160	R:R:T226	R:R:W183	23.04	No	Yes	3	4	5
161	R:R:C227	R:R:W183	3.92	Yes	Yes	3	6	5
162	R:R:P186	R:R:P187	5.84	No	No	0	6	6
163	R:R:P186	R:R:W191	8.11	No	Yes	0	6	5
164	R:R:P187	R:R:Y194	6.95	No	Yes	0	6	4
165	R:R:P187	R:R:Y219	12.52	No	Yes	0	6	7
166	R:R:S218	R:R:W191	12.36	No	Yes	0	4	5
167	R:R:W191	R:R:Y219	5.79	Yes	Yes	0	5	7
168	R:R:V222	R:R:W191	8.58	No	Yes	0	5	5
169	R:R:S192	R:R:V216	4.85	No	No	0	5	5
170	R:R:S192	R:R:Y219	6.36	No	Yes	0	5	7
171	R:R:R193	R:R:Y213	15.43	No	Yes	0	4	2
172	R:R:P196	R:R:W195	16.21	No	No	0	3	3
173	R:R:W195	R:R:Y213	8.68	No	Yes	0	3	2
174	R:R:K200	R:R:P196	5.02	No	No	6	3	3
175	R:R:G198	R:R:H197	3.18	No	No	0	4	5
176	R:R:G204	R:R:H197	3.18	No	No	0	4	5
177	R:R:F208	R:R:H197	7.92	Yes	No	0	5	5
178	R:R:S202	R:R:T201	3.2	No	No	0	5	5
179	R:R:D206	R:R:S209	7.36	No	No	9	4	5
180	R:R:D206	R:R:S211	11.78	No	No	9	4	4
181	R:R:D206	R:R:V216	8.76	No	No	0	4	5
182	R:R:F208	R:R:V207	13.11	Yes	No	0	5	4
183	R:R:M220	R:R:V207	4.56	No	No	0	5	4
184	R:R:F208	R:R:Y284	8.25	Yes	No	2	5	7
185	R:R:A304	R:R:F208	9.71	No	Yes	0	4	5
186	R:R:F208	R:R:P307	8.67	Yes	No	2	5	6
187	R:R:S209	R:R:S211	4.89	No	No	9	5	4
188	R:R:S211	R:R:Y213	6.36	No	Yes	0	4	2
189	R:R:S212	R:R:Y213	3.82	No	Yes	0	1	2
190	R:R:G215	R:R:S218	3.71	No	No	0	3	4
191	R:R:P295	R:R:Q217	4.74	No	No	0	1	4
192	R:R:M220	R:R:Y219	3.59	No	Yes	0	5	7
193	R:R:L223	R:R:Y219	9.38	No	Yes	0	5	7
194	R:R:A288	R:R:M220	3.22	No	No	0	5	5
195	R:R:C227	R:R:L223	3.17	Yes	No	0	6	5
196	R:R:I229	R:R:M224	4.37	No	No	0	4	5
197	R:R:C289	R:R:M224	3.24	No	No	0	6	5
198	R:R:C227	R:R:T226	5.07	Yes	No	3	6	4
199	R:R:P231	R:R:T230	5.25	No	No	0	9	4
200	R:R:L232	R:R:V236	2.98	No	No	0	6	5
201	R:R:F277	R:R:L232	9.74	Yes	No	0	9	6
202	R:R:F277	R:R:I235	3.77	Yes	No	0	9	8
203	R:R:V270	R:R:Y239	5.05	No	Yes	0	8	9
204	R:R:M273	R:R:Y239	10.78	No	Yes	0	8	9
205	R:R:L240	R:R:L244	4.15	No	No	0	3	1
206	R:R:L244	R:R:W243	4.56	No	No	0	1	6
207	R:R:R247	R:R:W243	9	No	No	0	5	6
208	R:R:T267	R:R:W243	7.28	No	No	0	7	6
209	R:R:E263	R:R:I246	6.83	No	No	0	7	8
210	R:R:I246	R:R:V266	6.14	No	No	0	8	8
211	R:R:E263	R:R:R247	4.65	No	No	0	7	5
212	R:R:A250	R:R:Q260	4.55	No	No	0	4	4
213	R:R:A250	R:R:E263	3.02	No	No	0	4	7
214	R:R:Q252	R:R:Q253	5.12	No	No	0	4	5
215	R:R:Q253	R:R:T259	4.25	No	Yes	0	5	4
216	R:R:S256	R:R:S258	3.26	No	No	0	5	4
217	R:R:S256	R:R:T259	6.4	No	Yes	0	5	4
218	R:R:E265	R:R:R268	9.3	No	No	0	7	7
219	R:R:M269	R:R:M325	4.33	No	No	0	8	7
220	R:R:L275	R:R:V271	2.98	No	No	0	4	5
221	R:R:I321	R:R:V272	3.07	No	No	0	8	6
222	R:R:M273	R:R:Y322	13.17	No	Yes	0	8	9
223	R:R:F277	R:R:W281	3.01	Yes	Yes	2	9	8
224	R:R:F279	R:R:Y317	12.38	No	No	0	5	6
225	R:R:C280	R:R:W281	7.84	No	Yes	0	9	8
226	R:R:A314	R:R:C280	3.61	No	No	0	9	9
227	R:R:A311	R:R:W281	3.89	No	Yes	2	7	8
228	R:R:G282	R:R:P283	4.06	No	No	0	4	9
229	R:R:F286	R:R:G282	3.01	No	No	0	5	4
230	R:R:F310	R:R:P283	8.67	No	No	0	7	9
231	R:R:P307	R:R:Y284	6.95	No	No	2	6	7
232	R:R:F287	R:R:M303	3.73	No	No	0	5	4
233	R:R:F287	R:R:P307	10.11	No	No	0	5	6
234	R:R:F290	R:R:N294	9.67	No	Yes	5	3	3
235	R:R:F290	R:R:Y297	3.09	No	Yes	5	3	2
236	R:R:F290	R:R:F299	6.43	No	No	5	3	3
237	R:R:N294	R:R:Y297	12.79	Yes	Yes	5	3	2
238	R:R:P298	R:R:Y297	5.56	No	Yes	0	1	2
239	R:R:F299	R:R:Y297	7.22	No	Yes	5	3	2
240	R:R:H300	R:R:M303	3.94	No	No	0	4	4
241	R:R:L302	R:R:P301	4.93	No	No	0	1	3
242	R:R:F310	R:R:L306	7.31	No	No	0	7	4
243	R:R:F309	R:R:F310	7.5	No	No	0	5	7
244	R:R:S313	R:R:Y317	11.45	No	No	0	5	6
245	R:R:A314	R:R:N318	4.69	No	Yes	0	9	9
246	R:R:I321	R:R:Y322	6.04	No	Yes	0	8	9
247	R:R:F329	R:R:V323	5.24	Yes	Yes	0	8	7
248	R:R:F324	R:R:I333	5.02	No	No	0	6	6
249	R:R:F329	R:R:N326	9.67	Yes	No	0	8	8
250	R:R:L128	R:R:T132	2.95	No	No	0	4	4
251	R:R:I61	R:R:I65	2.94	No	No	0	4	4
252	R:R:G117	R:R:Y53	2.9	No	Yes	0	4	4
253	R:R:L168	R:R:M153	2.83	No	Yes	0	4	5
254	R:R:A77	R:R:F329	2.77	No	Yes	0	7	8
255	R:R:A169	R:R:F164	2.77	No	Yes	0	7	6
256	R:R:A185	R:R:F189	2.77	No	No	0	3	5
257	R:R:L100	R:R:N71	2.75	No	Yes	0	7	9
258	R:R:K83	R:R:Q328	2.71	No	No	0	6	6
259	R:R:E257	R:R:K261	2.7	No	No	0	1	5
260	R:R:L84	R:R:Q328	2.66	No	No	0	7	6
261	R:R:L240	R:R:Q241	2.66	No	No	0	3	4
262	R:R:F324	R:R:V323	2.62	No	Yes	0	6	7
263	R:R:C136	R:R:W177	2.61	No	Yes	0	7	9
264	R:R:F69	R:R:T70	2.59	No	No	0	3	8
265	R:R:R85	R:R:T78	2.59	No	No	0	8	7
266	R:R:F329	R:R:T78	2.59	Yes	No	0	8	7
267	R:R:A166	R:R:W90	2.59	No	No	0	2	5
268	R:R:A98	R:R:W177	2.59	No	Yes	0	8	9
269	R:R:A145	R:R:W142	2.59	No	Yes	0	7	5
270	R:R:V115	R:R:Y116	2.52	No	No	0	5	4
271	R:R:V242	R:R:Y239	2.52	No	Yes	0	8	9
272	R:R:F62	R:R:I65	2.51	No	No	0	4	4
273	R:R:F299	R:R:M303	2.49	No	No	0	3	4
274	R:R:F69	R:R:L73	2.44	No	No	0	3	6
275	R:R:I170	R:R:W90	2.35	No	No	0	2	5
276	R:R:R327	R:R:R330	2.13	No	No	0	5	8
277	R:R:G210	R:R:G296	2.11	No	No	0	1	1
278	L:L:?1	R:R:A285	2.1	Yes	No	0	0	6
279	R:R:G198	R:R:P301	2.03	No	No	0	4	3
280	R:R:G204	R:R:P205	2.03	No	No	0	4	4
281	R:R:G215	R:R:P214	2.03	No	No	0	3	2
282	R:R:A48	R:R:P49	1.87	No	No	0	3	4
283	R:R:G172	R:R:V171	1.84	No	No	0	5	2
284	R:R:A101	R:R:C136	1.81	No	No	0	5	7
285	R:R:A245	R:R:C156	1.81	No	No	0	6	7
286	R:R:P319	R:R:V320	1.77	No	No	0	9	6
287	R:R:G172	R:R:I146	1.76	No	Yes	0	5	7
288	R:R:G160	R:R:N161	1.7	No	No	0	4	7
289	R:R:A250	R:R:T259	1.68	No	Yes	0	4	4
290	R:R:E41	R:R:G42	1.64	No	No	0	7	3
291	R:R:S110	R:R:S202	1.63	No	No	0	6	5
292	R:R:N294	R:R:P295	1.63	Yes	No	0	3	1
293	R:R:S57	R:R:V58	1.62	No	No	0	6	5
294	R:R:A101	R:R:I105	1.62	No	No	0	5	5
295	R:R:A262	R:R:I246	1.62	No	No	0	6	8
296	R:R:A276	R:R:I321	1.62	No	No	0	6	8
297	R:R:A308	R:R:K312	1.61	No	No	0	5	7
298	R:R:V93	R:R:V97	1.6	No	No	0	6	7
299	R:R:S107	R:R:T108	1.6	No	No	0	7	7
300	R:R:T108	R:R:V104	1.59	No	No	0	7	4
301	R:R:T259	R:R:V249	1.59	Yes	No	0	4	6
302	R:R:A181	R:R:L135	1.58	No	No	0	3	5
303	R:R:A293	R:R:N294	1.56	No	Yes	0	5	3
304	R:R:I234	R:R:S233	1.55	No	No	0	5	4
305	R:R:I61	R:R:V111	1.54	No	No	0	4	6
306	R:R:I316	R:R:V63	1.54	No	No	0	7	7
307	R:R:I229	R:R:V225	1.54	No	No	0	4	4
308	R:R:I235	R:R:V274	1.54	No	No	0	8	8
309	R:R:A292	R:R:Q217	1.52	No	No	0	4	4
310	R:R:G190	R:R:R193	1.5	No	No	0	5	4
311	R:R:I47	R:R:N44	1.42	No	No	0	2	5
312	R:R:K167	R:R:L168	1.41	No	No	0	4	4
313	R:R:C280	R:R:F279	1.4	No	No	0	9	5
314	R:R:K254	R:R:Q260	1.36	No	No	0	4	4
315	R:R:K251	R:R:R247	1.24	No	No	0	5	5
316	R:R:M325	R:R:R330	1.24	No	No	0	7	8
317	R:R:V182	R:R:W183	1.23	No	Yes	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.56	10	2	0
2	R:R:P39	8.38	4	6	8
3	R:R:F40	4.685	4	0	4
4	R:R:Y53	3.9625	4	0	4
5	R:R:N71	7.735	4	1	9
6	R:R:I91	6.104	5	1	7
7	R:R:N94	6.67	5	1	9
8	R:R:D99	8.605	4	1	9
9	R:R:F119	8.696	5	7	7
10	R:R:L121	6.0425	4	0	6
11	R:R:Y131	6.584	5	0	6
12	R:R:L141	3.9425	4	2	7
13	R:R:W142	8.666	5	3	5
14	R:R:S143	4.78	4	1	8
15	R:R:I146	3.7125	4	1	7
16	R:R:W152	6.67667	6	4	8
17	R:R:M153	4.71	5	4	5
18	R:R:F159	6.48	4	4	5
19	R:R:F164	7.2275	4	0	6
20	R:R:S176	3.635	4	1	7
21	R:R:W177	7.212	5	1	9
22	R:R:W179	12.3675	4	3	4
23	R:R:W183	9.936	5	3	5
24	R:R:W191	8.71	4	0	5
25	R:R:Y194	5.5175	4	0	4
26	R:R:F208	9.532	5	2	5
27	R:R:Y213	8.5725	4	0	2
28	R:R:Y219	7.528	5	0	7
29	R:R:C227	5.112	5	3	6
30	R:R:Y239	7.508	5	0	9
31	R:R:T259	3.48	4	0	4
32	R:R:F277	5.0425	4	2	9
33	R:R:W281	5.072	5	2	8
34	R:R:N294	6.4125	4	5	3
35	R:R:Y297	7.165	4	5	2
36	R:R:T315	7.495	4	1	8
37	R:R:N318	5.265	4	1	9
38	R:R:Y322	8.656	5	1	9
39	R:R:V323	6.26	4	0	7
40	R:R:F329	6.615	6	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L223	88.5399	6.44	Yes	No	0	0	5
2	R:R:L223	R:R:Y219	92.9432	9.38	No	Yes	0	5	7
3	R:R:S192	R:R:Y219	100	6.36	No	Yes	0	5	7
4	R:R:S192	R:R:V216	99.5839	4.85	No	No	0	5	5
5	R:R:D206	R:R:V216	99.1623	8.76	No	No	0	4	5
6	R:R:D206	R:R:S211	97.9554	11.78	No	No	9	4	4
7	R:R:S211	R:R:Y213	97.8645	6.36	No	Yes	0	4	2
8	R:R:W195	R:R:Y213	49.679	8.68	No	Yes	0	3	2
9	R:R:R193	R:R:Y213	47.3148	15.43	No	Yes	0	4	2
10	R:R:H123	R:R:R193	46.061	7.9	No	No	0	2	4
11	R:R:F40	R:R:H123	90.59	5.66	Yes	No	0	4	2
12	R:R:H123	R:R:W195	45.9398	8.46	No	No	0	2	3
13	R:R:F119	R:R:F40	86.8287	4.29	Yes	Yes	0	7	4
14	R:R:F119	R:R:N113	59.5768	20.54	Yes	No	0	7	6
15	R:R:L121	R:R:N113	58.0171	8.24	Yes	No	0	6	6
16	R:R:L121	R:R:V120	54.5728	2.98	Yes	No	0	6	3
17	R:R:V120	R:R:Y118	43.1154	8.83	No	No	0	3	5
18	R:R:P43	R:R:Y118	38.0012	6.95	No	No	8	6	5
19	R:R:P43	R:R:Y45	36.4471	9.74	No	No	0	6	3
20	R:R:R50	R:R:Y45	34.7662	8.23	No	No	0	1	3
21	L:L:?1	R:R:Y284	24.9235	16.37	Yes	No	2	0	7
22	R:R:R50	R:R:Y53	33.0798	3.09	No	Yes	0	1	4
23	R:R:L199	R:R:Y53	21.1209	5.86	No	Yes	0	4	4
24	R:R:V120	R:R:Y116	10.661	16.4	No	No	0	3	4
25	R:R:L199	R:R:T56	19.3877	4.42	No	No	0	4	4
26	R:R:T56	R:R:W59	17.6518	4.85	No	No	0	4	4
27	R:R:F309	R:R:W59	10.6528	14.03	No	No	0	5	4
28	R:R:F119	R:R:Q129	25.3451	4.68	Yes	No	0	7	5
29	R:R:Q129	R:R:S202	21.7106	4.33	No	No	0	5	5
30	R:R:S110	R:R:S202	18.1312	1.63	No	No	0	6	5
31	R:R:M60	R:R:S110	16.3319	7.67	No	No	0	7	6
32	L:L:?1	R:R:W281	95.481	6.06	Yes	Yes	2	0	8
33	R:R:C280	R:R:W281	43.8235	7.84	No	Yes	0	9	8
34	R:R:A314	R:R:C280	41.7404	3.61	No	No	0	9	9
35	R:R:A314	R:R:N318	41.283	4.69	No	Yes	0	9	9
36	R:R:D99	R:R:N318	36.6069	5.39	Yes	Yes	1	9	9
37	R:R:D99	R:R:N71	41.7128	10.77	Yes	Yes	1	9	9
38	R:R:N71	R:R:T70	35.5928	4.39	Yes	No	1	9	8
39	R:R:F69	R:R:T70	34.5375	2.59	No	No	0	3	8
40	R:R:F69	R:R:L73	33.3223	2.44	No	No	0	3	6
41	R:R:F324	R:R:L73	32.0934	3.65	No	No	0	6	6
42	R:R:F324	R:R:V323	29.663	2.62	No	Yes	0	6	7
43	R:R:F329	R:R:V323	20.8399	5.24	Yes	Yes	0	8	7
44	R:R:F277	R:R:W281	55.7383	3.01	Yes	Yes	2	9	8
45	R:R:F277	R:R:I235	59.2709	3.77	Yes	No	0	9	8
46	R:R:I235	R:R:S148	58.4222	6.19	No	No	0	8	8
47	R:R:C238	R:R:S148	54.3689	5.16	No	No	0	7	8
48	R:R:C238	R:R:W152	53.432	7.84	No	Yes	0	7	8
49	R:R:W149	R:R:W152	11.6145	3.75	No	Yes	0	6	8
50	R:R:M153	R:R:W149	10.7933	6.98	Yes	No	0	5	6
51	R:R:F164	R:R:M153	25.8328	3.73	Yes	Yes	0	6	5
52	R:R:F164	R:R:L88	16.522	6.09	Yes	No	0	6	8
53	R:R:H86	R:R:L88	11.9148	7.71	No	No	0	8	8
54	R:R:P158	R:R:W152	11.6089	14.86	No	Yes	4	7	8
55	R:R:M153	R:R:P158	10.7878	5.03	Yes	No	4	5	7
56	R:R:F159	R:R:W152	12.7084	4.01	Yes	Yes	4	5	8
57	R:R:F159	R:R:M153	11.1377	4.98	Yes	Yes	4	5	5
58	R:R:S148	R:R:Y239	31.6167	8.9	No	Yes	0	8	9
59	R:R:R151	R:R:Y239	22.3471	10.29	No	Yes	0	9	9
60	R:R:I147	R:R:R151	13.8326	7.52	No	No	1	9	9
61	R:R:I147	R:R:I91	34.0718	7.36	No	Yes	1	9	7
62	R:R:L144	R:R:N318	27.7782	5.49	No	Yes	1	8	9
63	R:R:L144	R:R:Y322	39.5442	12.89	No	Yes	1	8	9
64	R:R:I147	R:R:Y322	21.6032	6.04	No	Yes	1	9	9
65	R:R:I91	R:R:N94	18.021	4.25	Yes	Yes	1	7	9
66	R:R:N94	R:R:W177	13.3311	10.17	Yes	Yes	1	9	9
67	R:R:P187	R:R:Y219	15.1746	12.52	No	Yes	0	6	7
68	R:R:P187	R:R:Y194	13.3697	6.95	No	Yes	0	6	4
69	R:R:Q241	R:R:W152	28.9686	4.38	No	Yes	0	4	8
70	R:R:F208	R:R:V207	12.3309	13.11	Yes	No	0	5	4
71	R:R:M220	R:R:V207	12.7277	4.56	No	No	0	5	4
72	R:R:P307	R:R:Y284	17.8474	6.95	No	No	2	6	7
73	R:R:F287	R:R:P307	24.535	10.11	No	No	0	5	6
74	R:R:F287	R:R:M303	23.1325	3.73	No	No	0	5	4
75	R:R:F299	R:R:M303	20.3659	2.49	No	No	0	3	4
76	R:R:F299	R:R:Y297	10.2009	7.22	No	Yes	5	3	2
77	R:R:L240	R:R:Q241	27.5633	2.66	No	No	0	3	4
78	R:R:L240	R:R:L244	26.1525	4.15	No	No	0	3	1
79	R:R:L244	R:R:W243	24.7362	4.56	No	No	0	1	6
80	R:R:R247	R:R:W243	21.9751	9	No	No	0	5	6
81	R:R:E263	R:R:R247	19.0984	4.65	No	No	0	7	5
82	R:R:A250	R:R:E263	13.3835	3.02	No	No	0	4	7
83	R:R:M220	R:R:Y219	12.9784	3.59	No	Yes	0	5	7
84	R:R:E150	R:R:F164	10.7437	16.32	No	Yes	0	8	6
85	R:R:L144	R:R:L95	12.2923	4.15	No	No	1	8	9
86	R:R:D99	R:R:L95	12.0801	8.14	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:V133	3.96	2	Yes	No	0	6	0	1
L:L:?1	R:R:L223	6.44	2	Yes	No	0	5	0	1
L:L:?1	R:R:M224	5.64	2	Yes	No	0	5	0	1
L:L:?1	R:R:C228	7.39	2	Yes	No	0	7	0	1
L:L:?1	R:R:W281	6.06	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y284	16.37	2	Yes	No	0	7	0	1
L:L:?1	R:R:A288	3.14	2	Yes	No	0	5	0	1
L:L:?1	R:R:A311	4.19	2	Yes	No	0	7	0	1
L:L:?1	R:R:K312	10.31	2	Yes	No	0	7	0	1
R:R:A106	R:R:V133	5.09	0	No	No	6	6	2	1
R:R:F277	R:R:L141	3.65	2	Yes	Yes	9	7	2	2
R:R:L141	R:R:W281	4.56	2	Yes	Yes	7	8	2	1
R:R:F208	R:R:Y284	8.25	2	Yes	No	5	7	2	1
R:R:F208	R:R:P307	8.67	2	Yes	No	5	6	2	2
R:R:M220	R:R:Y219	3.59	0	No	Yes	5	7	2	2
R:R:L223	R:R:Y219	9.38	0	No	Yes	5	7	1	2
R:R:A288	R:R:M220	3.22	0	No	No	5	5	1	2
R:R:C227	R:R:L223	3.17	3	Yes	No	6	5	2	1
R:R:I229	R:R:M224	4.37	0	No	No	4	5	2	1
R:R:C289	R:R:M224	3.24	0	No	No	6	5	2	1
R:R:F277	R:R:W281	3.01	2	Yes	Yes	9	8	2	1
R:R:C280	R:R:W281	7.84	0	No	Yes	9	8	2	1
R:R:A311	R:R:W281	3.89	2	No	Yes	7	8	1	1
R:R:P307	R:R:Y284	6.95	2	No	No	6	7	2	1
L:L:?1	R:R:A285	2.1	2	Yes	No	0	6	0	1
R:R:A308	R:R:K312	1.61	0	No	No	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Y01_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	283
Number of Links	317
Number of Hubs	40
Number of Links mediated by Hubs	155
Number of Communities	9
Number of Nodes involved in Communities	54
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	74159
Length Of Smallest Path	3
Average Path Length	19.2074
Length of Longest Path	44
Minimum Path Strength	1.595
Average Path Strength	6.72204
Maximum Path Strength	16.4
Minimum Path Correlation	0.7
Average Path Correlation	0.930689
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	41.7422
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.4994
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • identical protein binding • regulation of cytokinesis • positive regulation of cell division • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • response to light stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • multicellular organismal process • sensory perception of light stimulus • system process • sensory perception • nervous system process • visual perception • phototransduction • detection of light stimulus • detection of external stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	RET
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	RET
Name	RETINAL
Synonyms
Identifier
Formula	C20 H28 O
Molecular Weight	284.436
SMILES
PubChem	638015
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P04001
Sequence	>8Y01_nogp_Chain_R G P F E G P N Y H I A P R W V Y H L T S V W M I F V V I A S V F T N G L V L A A T M K F K K L R H P L N W I L V N L A V A D L A E T V I A S T I S V V N Q V Y G Y F V L G H P M C V L G Y T V S L C G I T G L W S L A I I S W E R W M V V C K P F G N V R F D A K L A I V G I A F S W I W A A V W T A P P I F G W S R Y W P H G L K T S C G P D V F S G S S Y P G V Q S Y M I V L M V T C C I T P L S I I V L C Y L Q V W L A I R A V A K Q Q K E S E S T Q K A E K E V T R M V V V M V L A F C F C W G P Y A F F A C F A A A N P G Y P F H P L M A A L P A F F A K S A T I Y N P V I Y V F M N R Q F R N C I L Q Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Y01	A	Sensory	Opsins	Opsin1MW	Homo sapiens	Retinal	-	Gi1/β1/γ2	2.48	2025-02-12	To be published
	8Y01 (No Gprot)	A	Sensory	Opsins	Opsin1MW	Homo sapiens	Retinal	-		2.48	2025-02-12	To be published

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