psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F206	4.05	Yes	Yes	0	0	8
2	L:L:?1	R:R:Y262	18.71	Yes	Yes	1	0	7
3	L:L:?1	R:R:S286	3.99	Yes	No	1	0	6
4	L:L:?1	R:R:S289	7.99	Yes	No	1	0	8
5	L:L:?1	R:R:K290	7.5	Yes	Yes	1	0	7
6	R:R:L177	R:R:Q34	13.31	No	No	0	4	4
7	R:R:F287	R:R:Q34	8.2	No	No	0	4	4
8	R:R:F37	R:R:V41	3.93	No	Yes	0	5	7
9	R:R:F287	R:R:F37	24.65	No	No	0	4	5
10	R:R:F37	R:R:K290	4.96	No	Yes	0	5	7
11	R:R:M38	R:R:V88	6.09	No	No	0	7	5
12	R:R:K290	R:R:M38	8.64	Yes	No	0	7	7
13	R:R:F89	R:R:G39	4.52	No	No	0	6	4
14	R:R:V41	R:R:V85	6.41	Yes	No	0	7	7
15	R:R:I294	R:R:V41	4.61	No	Yes	0	6	7
16	R:R:F42	R:R:F46	12.86	No	Yes	0	6	5
17	R:R:F42	R:R:F86	17.15	No	No	0	6	8
18	R:R:I294	R:R:I44	5.89	No	No	0	6	5
19	R:R:F46	R:R:P47	4.33	Yes	No	0	5	4
20	R:R:F46	R:R:F78	5.36	Yes	Yes	0	5	7
21	R:R:N49	R:R:P297	14.66	No	No	0	9	9
22	R:R:S74	R:R:V52	6.46	No	No	0	9	9
23	R:R:C301	R:R:V52	8.54	No	No	0	7	9
24	R:R:L53	R:R:S74	7.51	No	No	0	7	9
25	R:R:F78	R:R:L53	4.87	Yes	No	0	7	7
26	R:R:R58	R:R:V54	5.23	No	No	0	5	4
27	R:R:T56	R:R:V71	4.76	No	No	0	7	5
28	R:R:R58	R:R:Y59	4.12	No	No	0	5	5
29	R:R:C310	R:R:Y59	13.44	No	No	0	6	5
30	R:R:K60	R:R:R63	8.66	No	No	0	6	7
31	R:R:F307	R:R:L62	14.61	Yes	No	0	8	8
32	R:R:C310	R:R:L62	9.52	No	No	0	6	8
33	R:R:P65	R:R:Q64	4.74	No	No	0	6	7
34	R:R:L66	R:R:V132	5.96	No	No	0	8	8
35	R:R:N67	R:R:Q306	7.92	No	No	0	8	7
36	R:R:F307	R:R:N67	7.25	Yes	No	0	8	8
37	R:R:A147	R:R:Y68	5.34	No	No	0	7	5
38	R:R:L148	R:R:Y68	4.69	No	No	0	2	5
39	R:R:I69	R:R:S121	6.19	No	No	0	7	8
40	R:R:I69	R:R:L125	4.28	No	No	0	7	8
41	R:R:E128	R:R:I69	8.2	No	No	0	9	7
42	R:R:L125	R:R:L70	8.3	No	No	0	8	8
43	R:R:L70	R:R:N304	4.12	No	No	0	8	8
44	R:R:N72	R:R:V117	4.43	Yes	No	4	9	7
45	R:R:N72	R:R:S121	7.45	Yes	No	4	9	8
46	R:R:N72	R:R:V151	10.35	Yes	No	0	9	7
47	R:R:N72	R:R:T154	7.31	Yes	No	4	9	7
48	R:R:N72	R:R:W155	11.3	Yes	Yes	4	9	9
49	R:R:L122	R:R:V73	5.96	No	No	0	8	9
50	R:R:F75	R:R:F78	4.29	No	Yes	0	6	7
51	R:R:F75	R:R:L79	13.4	No	No	0	6	7
52	R:R:F75	R:R:W155	6.01	No	Yes	0	6	9
53	R:R:A114	R:R:L80	4.73	No	No	0	7	7
54	R:R:C81	R:R:V85	5.12	No	No	0	6	7
55	R:R:C293	R:R:C81	5.46	No	No	0	8	6
56	R:R:F83	R:R:L110	8.53	No	No	0	5	4
57	R:R:Q107	R:R:S84	5.78	Yes	Yes	0	8	6
58	R:R:F86	R:R:F89	5.36	No	No	0	8	6
59	R:R:P87	R:R:Q107	6.32	No	Yes	0	5	8
60	R:R:F99	R:R:V90	6.55	No	No	0	7	4
61	R:R:F97	R:R:F99	10.72	No	No	7	8	7
62	R:R:F97	R:R:V103	3.93	No	No	7	8	5
63	R:R:F99	R:R:V103	9.18	No	No	7	7	5
64	R:R:H102	R:R:R101	7.9	No	No	0	1	3
65	R:R:C104	R:R:C181	7.28	No	No	0	9	9
66	R:R:L106	R:R:L110	4.15	No	No	0	5	4
67	R:R:Q107	R:R:S180	4.33	Yes	No	0	8	5
68	R:R:F109	R:R:V113	7.87	Yes	No	2	6	5
69	R:R:F109	R:R:S162	5.28	Yes	No	2	6	6
70	R:R:F109	R:R:F166	8.57	Yes	No	2	6	5
71	R:R:F109	R:R:F172	4.29	Yes	Yes	2	6	5
72	R:R:S162	R:R:T112	4.8	No	No	2	6	4
73	R:R:F172	R:R:T112	6.49	Yes	No	2	5	4
74	R:R:P183	R:R:T112	5.25	Yes	No	2	4	4
75	R:R:S162	R:R:V113	4.85	No	No	2	6	5
76	R:R:C205	R:R:L116	6.35	No	No	0	6	5
77	R:R:V117	R:R:W155	14.71	No	Yes	4	7	9
78	R:R:G119	R:R:Y259	4.35	No	Yes	0	7	8
79	R:R:F124	R:R:W120	7.02	No	Yes	0	6	5
80	R:R:I157	R:R:W120	10.57	No	Yes	5	4	5
81	R:R:F204	R:R:W120	8.02	Yes	Yes	5	4	5
82	R:R:V208	R:R:W120	4.9	No	Yes	0	5	5
83	R:R:P209	R:R:W120	12.16	No	Yes	0	9	5
84	R:R:S121	R:R:T154	6.4	No	No	4	8	7
85	R:R:L122	R:R:Y300	17.58	No	Yes	0	8	9
86	R:R:F124	R:R:V150	3.93	No	No	0	6	5
87	R:R:L125	R:R:R129	15.79	No	No	0	8	9
88	R:R:A126	R:R:I213	4.87	No	No	0	9	8
89	R:R:A126	R:R:Y217	9.34	No	Yes	0	9	9
90	R:R:F127	R:R:L212	8.53	No	No	0	5	6
91	R:R:E128	R:R:F142	12.83	No	No	0	9	6
92	R:R:E128	R:R:V150	5.7	No	No	0	9	5
93	R:R:R129	R:R:Y217	10.29	No	Yes	0	9	9
94	R:R:C134	R:R:Y130	6.72	No	Yes	0	7	8
95	R:R:P136	R:R:Y130	12.52	No	Yes	3	8	8
96	R:R:F215	R:R:Y130	11.35	No	Yes	3	4	8
97	R:R:Q219	R:R:Y130	4.51	Yes	Yes	3	4	8
98	R:R:I131	R:R:P136	8.47	Yes	No	3	5	8
99	R:R:F137	R:R:I131	6.28	No	Yes	3	5	5
100	R:R:F142	R:R:I131	5.02	No	Yes	0	6	5
101	R:R:I133	R:R:L220	14.27	No	No	0	8	8
102	R:R:K135	R:R:N139	5.6	No	No	0	5	5
103	R:R:F140	R:R:K135	8.69	No	No	0	3	5
104	R:R:F137	R:R:P136	13	No	No	3	5	8
105	R:R:F142	R:R:R141	4.28	No	No	0	6	4
106	R:R:H146	R:R:R141	11.28	No	No	0	4	4
107	R:R:K145	R:R:S143	6.12	No	No	8	4	6
108	R:R:H146	R:R:S143	9.76	No	No	8	4	6
109	R:R:H146	R:R:K145	13.1	No	No	8	4	4
110	R:R:F204	R:R:I157	5.02	Yes	No	5	4	4
111	R:R:F200	R:R:V161	7.87	No	Yes	5	4	5
112	R:R:L201	R:R:V161	4.47	No	Yes	0	4	5
113	R:R:F204	R:R:V161	3.93	Yes	Yes	5	4	5
114	R:R:P164	R:R:P165	5.84	No	No	0	7	4
115	R:R:P164	R:R:W169	6.76	No	Yes	0	7	5
116	R:R:F172	R:R:P165	13	Yes	No	0	5	4
117	R:R:P165	R:R:Y197	9.74	No	Yes	0	4	6
118	R:R:F166	R:R:F172	8.57	No	Yes	2	5	5
119	R:R:S196	R:R:W169	7.41	No	Yes	0	5	5
120	R:R:W169	R:R:Y197	10.61	Yes	Yes	0	5	6
121	R:R:F200	R:R:W169	8.02	No	Yes	0	4	5
122	R:R:S170	R:R:Y197	11.45	No	Yes	0	5	6
123	R:R:K191	R:R:R171	4.95	No	No	0	2	4
124	R:R:F172	R:R:P183	5.78	Yes	Yes	2	5	4
125	R:R:D184	R:R:I173	7	Yes	No	6	4	2
126	R:R:I173	R:R:Y186	7.25	No	No	6	2	4
127	R:R:C181	R:R:P174	5.65	No	No	0	9	3
128	R:R:E175	R:R:W185	4.36	No	Yes	0	4	6
129	R:R:G182	R:R:P183	4.06	No	Yes	0	3	4
130	R:R:P183	R:R:Y197	4.17	Yes	Yes	0	4	6
131	R:R:D184	R:R:Y186	9.2	Yes	No	6	4	4
132	R:R:D184	R:R:T187	8.67	Yes	No	6	4	4
133	R:R:D184	R:R:K191	8.3	Yes	No	6	4	2
134	R:R:D184	R:R:S194	11.78	Yes	No	0	4	4
135	R:R:W185	R:R:Y262	11.58	Yes	Yes	1	6	7
136	R:R:F265	R:R:W185	4.01	No	Yes	1	5	6
137	R:R:M269	R:R:W185	4.65	No	Yes	0	5	6
138	R:R:P285	R:R:W185	4.05	Yes	Yes	1	5	6
139	R:R:T187	R:R:Y186	17.48	No	No	6	4	4
140	R:R:K191	R:R:T187	6.01	No	No	6	2	4
141	R:R:L201	R:R:Y197	10.55	No	Yes	0	4	6
142	R:R:T198	R:R:V270	4.76	No	No	0	5	4
143	R:R:M267	R:R:W199	9.31	No	No	0	5	4
144	R:R:V270	R:R:W199	4.9	No	No	0	4	4
145	R:R:F200	R:R:F204	7.5	No	Yes	5	4	4
146	R:R:F202	R:R:F206	4.29	Yes	Yes	0	5	8
147	R:R:F202	R:R:I207	7.54	Yes	No	0	5	4
148	R:R:F202	R:R:M267	14.93	Yes	No	0	5	5
149	R:R:F206	R:R:V260	3.93	Yes	No	0	8	6
150	R:R:A263	R:R:F206	8.32	No	Yes	0	7	8
151	R:R:F255	R:R:P209	4.33	Yes	No	0	9	9
152	R:R:F255	R:R:L210	8.53	Yes	No	0	9	6
153	R:R:C256	R:R:L210	4.76	Yes	No	0	5	6
154	R:R:F255	R:R:I213	6.28	Yes	No	0	9	8
155	R:R:F215	R:R:Q219	8.2	No	Yes	3	4	4
156	R:R:V248	R:R:Y217	6.31	No	Yes	0	8	9
157	R:R:M251	R:R:Y217	10.78	No	Yes	0	8	9
158	R:R:Q219	R:R:T218	5.67	Yes	No	0	4	4
159	R:R:Q219	R:R:R222	4.67	Yes	No	0	4	3
160	R:R:L221	R:R:V248	8.94	No	No	0	6	8
161	R:R:L224	R:R:V244	4.47	No	No	0	8	8
162	R:R:E241	R:R:K225	8.1	No	No	0	7	4
163	R:R:A228	R:R:Q238	4.55	No	No	0	4	4
164	R:R:A228	R:R:E241	4.53	No	No	0	4	7
165	R:R:Q231	R:R:T237	4.25	No	Yes	0	4	4
166	R:R:S234	R:R:T237	6.4	No	Yes	0	4	4
167	R:R:E243	R:R:K239	12.15	No	No	0	7	5
168	R:R:E243	R:R:K305	5.4	No	No	0	7	5
169	R:R:M247	R:R:M251	4.33	No	No	0	8	8
170	R:R:M247	R:R:M303	4.33	No	No	0	8	7
171	R:R:I299	R:R:V250	4.61	No	No	0	8	6
172	R:R:M251	R:R:Y300	11.97	No	Yes	0	8	9
173	R:R:S254	R:R:Y295	5.09	No	Yes	9	7	6
174	R:R:N296	R:R:S254	4.47	No	No	9	9	7
175	R:R:F255	R:R:Y259	14.44	Yes	Yes	0	9	8
176	R:R:C256	R:R:V260	5.12	Yes	No	0	5	6
177	R:R:V257	R:R:Y295	5.05	No	Yes	0	5	6
178	R:R:C258	R:R:Y259	12.1	No	Yes	0	8	8
179	R:R:C258	R:R:Y295	5.38	No	Yes	0	8	6
180	R:R:F288	R:R:P261	17.34	No	No	0	7	9
181	R:R:P285	R:R:Y262	9.74	Yes	Yes	1	5	7
182	R:R:S286	R:R:Y262	5.09	No	Yes	1	6	7
183	R:R:S289	R:R:Y262	5.09	No	Yes	1	8	7
184	R:R:F265	R:R:Y268	4.13	No	No	0	5	4
185	R:R:F265	R:R:P285	10.11	No	Yes	1	5	5
186	R:R:K290	R:R:S286	6.12	Yes	No	1	7	6
187	R:R:S291	R:R:Y295	6.36	No	Yes	0	7	6
188	R:R:A292	R:R:Y295	5.34	No	Yes	0	9	6
189	R:R:N296	R:R:Y295	4.65	No	Yes	9	9	6
190	R:R:N296	R:R:Y300	6.98	No	Yes	0	9	9
191	R:R:I299	R:R:Y300	4.84	No	Yes	0	8	9
192	R:R:F302	R:R:I311	8.79	No	No	0	6	6
193	R:R:N304	R:R:Q306	6.6	No	No	0	8	7
194	R:R:F307	R:R:N304	7.25	Yes	No	0	8	8
195	R:R:C205	R:R:W120	3.92	No	Yes	0	6	5
196	R:R:F307	R:R:T56	3.89	Yes	No	0	8	7
197	R:R:Q230	R:R:Q231	3.84	No	No	0	3	4
198	R:R:F78	R:R:I82	3.77	Yes	No	0	7	4
199	R:R:F127	R:R:I131	3.77	No	Yes	0	5	5
200	R:R:T118	R:R:Y259	3.75	No	Yes	0	9	8
201	R:R:G111	R:R:S84	3.71	No	Yes	0	6	6
202	R:R:G100	R:R:V103	3.68	No	No	0	8	5
203	R:R:F302	R:R:L48	3.65	No	Yes	0	6	8
204	R:R:F109	R:R:L110	3.65	Yes	No	0	6	4
205	R:R:P261	R:R:V260	3.53	No	No	0	9	6
206	R:R:A126	R:R:S216	3.42	No	No	0	9	6
207	R:R:G77	R:R:N49	3.39	No	No	0	9	9
208	R:R:I163	R:R:P164	3.39	No	No	0	4	7
209	R:R:I173	R:R:P174	3.39	No	No	0	2	3
210	R:R:I284	R:R:P285	3.39	No	Yes	0	5	5
211	R:R:G108	R:R:Q107	3.29	No	Yes	0	5	8
212	R:R:L48	R:R:P297	3.28	Yes	No	0	8	9
213	R:R:C134	R:R:I133	3.27	No	No	0	7	8
214	R:R:A123	R:R:I213	3.25	No	No	0	7	8
215	R:R:S234	R:R:T236	3.2	No	No	0	4	3
216	R:R:C214	R:R:L210	3.17	No	No	0	5	6
217	R:R:I159	R:R:V113	3.07	No	No	0	4	5
218	R:R:I133	R:R:V132	3.07	No	No	0	8	8
219	R:R:K290	R:R:S84	3.06	Yes	Yes	0	7	6
220	R:R:C181	R:R:Q107	3.05	No	Yes	0	9	8
221	R:R:L80	R:R:S84	3	No	Yes	0	7	6
222	R:R:R193	R:R:W169	3	No	Yes	0	3	5
223	R:R:L221	R:R:S245	3	No	No	0	6	7
224	R:R:L221	R:R:V244	2.98	No	No	0	6	8
225	R:R:F97	R:R:P87	2.89	No	No	0	8	5
226	R:R:E195	R:R:S196	2.87	No	No	0	3	5
227	R:R:I44	R:R:L48	2.85	No	Yes	0	5	8
228	R:R:I298	R:R:L48	2.85	No	Yes	0	7	8
229	R:R:G76	R:R:W155	2.81	No	Yes	0	8	9
230	R:R:A105	R:R:F172	2.77	No	Yes	0	6	5
231	R:R:N67	R:R:Q64	2.64	No	No	0	8	7
232	R:R:A266	R:R:W185	2.59	No	Yes	0	5	6
233	R:R:Q232	R:R:Q238	2.56	No	No	0	4	4
234	R:R:S144	R:R:Y68	2.54	No	No	0	3	5
235	R:R:F167	R:R:I163	2.51	No	No	0	4	4
236	R:R:R193	R:R:Y192	2.06	No	No	0	3	3
237	R:R:C81	R:R:G45	1.96	No	No	0	6	8
238	R:R:C256	R:R:G253	1.96	Yes	No	0	5	4
239	R:R:A147	R:R:P65	1.87	No	No	0	7	6
240	R:R:G158	R:R:V117	1.84	No	No	0	8	7
241	R:R:G160	R:R:V161	1.84	No	Yes	0	3	5
242	R:R:G115	R:R:T118	1.82	No	No	0	7	9
243	R:R:A91	R:R:C179	1.81	No	No	0	5	5
244	R:R:A223	R:R:C134	1.81	No	No	0	6	7
245	R:R:C179	R:R:V88	1.71	No	No	0	5	5
246	R:R:C214	R:R:V252	1.71	No	No	0	5	7
247	R:R:C256	R:R:V252	1.71	Yes	No	0	5	7
248	R:R:A228	R:R:T237	1.68	No	Yes	0	4	4
249	R:R:E175	R:R:G176	1.64	No	No	0	4	3
250	R:R:T40	R:R:V41	1.59	No	Yes	0	4	7
251	R:R:T149	R:R:V150	1.59	No	No	0	3	5
252	R:R:T237	R:R:V227	1.59	Yes	No	0	4	5
253	R:R:A55	R:R:L62	1.58	No	No	0	8	8
254	R:R:A240	R:R:L224	1.58	No	No	0	5	8
255	R:R:I311	R:R:M51	1.46	No	No	0	6	5
256	R:R:A50	R:R:F46	1.39	No	Yes	0	4	5
257	R:R:A264	R:R:Y268	1.33	No	No	0	5	4
258	R:R:F140	R:R:V132	1.31	No	No	0	3	8
259	R:R:R63	R:R:T56	1.29	No	No	0	7	7
260	R:R:F202	R:R:I203	1.26	Yes	No	0	5	5
261	R:R:F42	R:R:L43	1.22	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.448	5	1	0
2	R:R:V41	4.135	4	0	7
3	R:R:F46	5.985	4	0	5
4	R:R:L48	3.1575	4	0	8
5	R:R:N72	8.168	5	4	9
6	R:R:F78	4.5725	4	0	7
7	R:R:S84	3.8875	4	0	6
8	R:R:Q107	4.554	5	0	8
9	R:R:F109	5.932	5	2	6
10	R:R:W120	7.765	6	5	5
11	R:R:Y130	8.775	4	3	8
12	R:R:I131	5.885	4	3	5
13	R:R:W155	8.7075	4	4	9
14	R:R:V161	4.5275	4	5	5
15	R:R:W169	7.16	5	0	5
16	R:R:F172	6.81667	6	2	5
17	R:R:P183	4.815	4	2	4
18	R:R:D184	8.99	5	6	4
19	R:R:W185	5.20667	6	1	6
20	R:R:Y197	9.304	5	0	6
21	R:R:F202	7.005	4	0	5
22	R:R:F204	6.1175	4	5	4
23	R:R:F206	5.1475	4	0	8
24	R:R:Y217	9.18	4	0	9
25	R:R:Q219	5.7625	4	3	4
26	R:R:T237	3.48	4	0	4
27	R:R:F255	8.395	4	0	9
28	R:R:C256	3.3875	4	0	5
29	R:R:Y259	8.66	4	0	8
30	R:R:Y262	10.042	5	1	7
31	R:R:P285	6.8225	4	1	5
32	R:R:K290	6.056	5	1	7
33	R:R:Y295	5.31167	6	9	6
34	R:R:Y300	10.3425	4	0	9
35	R:R:F307	8.25	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K290	66.9464	7.5	Yes	Yes	1	0	7
2	R:R:F37	R:R:K290	32.0234	4.96	No	Yes	0	5	7
3	R:R:F37	R:R:V41	26.0648	3.93	No	Yes	0	5	7
4	L:L:?1	R:R:F206	84.6097	4.05	Yes	Yes	0	0	8
5	R:R:F206	R:R:V260	92.735	3.93	Yes	No	0	8	6
6	R:R:C256	R:R:V260	95.2523	5.12	Yes	No	0	5	6
7	R:R:C256	R:R:L210	97.2384	4.76	Yes	No	0	5	6
8	R:R:F255	R:R:L210	100	8.53	Yes	No	0	9	6
9	R:R:F255	R:R:P209	78.7361	4.33	Yes	No	0	9	9
10	R:R:P209	R:R:W120	78.8104	12.16	No	Yes	0	9	5
11	R:R:F124	R:R:W120	62.2305	7.02	No	Yes	0	6	5
12	R:R:F124	R:R:V150	61.6675	3.93	No	No	0	6	5
13	R:R:E128	R:R:V150	60.7435	5.7	No	No	0	9	5
14	R:R:E128	R:R:I69	47.419	8.2	No	No	0	9	7
15	R:R:I69	R:R:S121	43.9352	6.19	No	No	0	7	8
16	R:R:N72	R:R:S121	40.3558	7.45	Yes	No	4	9	8
17	R:R:N72	R:R:W155	33.2289	11.3	Yes	Yes	4	9	9
18	R:R:F75	R:R:W155	29.8301	6.01	No	Yes	0	6	9
19	R:R:F75	R:R:F78	26.1976	4.29	No	Yes	0	6	7
20	R:R:F46	R:R:F78	15.4594	5.36	Yes	Yes	0	5	7
21	R:R:F255	R:R:I213	44.1423	6.28	Yes	No	0	9	8
22	R:R:A126	R:R:I213	42.9846	4.87	No	No	0	9	8
23	R:R:A126	R:R:Y217	42.1455	9.34	No	Yes	0	9	9
24	R:R:R129	R:R:Y217	37.7164	10.29	No	Yes	0	9	9
25	R:R:L125	R:R:R129	37.5518	15.79	No	No	0	8	9
26	R:R:I69	R:R:L125	40.2496	4.28	No	No	0	7	8
27	R:R:I294	R:R:V41	16.5374	4.61	No	Yes	0	6	7
28	R:R:I294	R:R:I44	14.9124	5.89	No	No	0	6	5
29	R:R:I44	R:R:L48	13.2767	2.85	No	Yes	0	5	8
30	R:R:L125	R:R:L70	37.5624	8.3	No	No	0	8	8
31	R:R:L70	R:R:N304	36.3303	4.12	No	No	0	8	8
32	R:R:F307	R:R:N304	24.4344	7.25	Yes	No	0	8	8
33	R:R:N304	R:R:Q306	10.9665	6.6	No	No	0	8	7
34	R:R:N67	R:R:Q64	16.787	2.64	No	No	0	8	7
35	R:R:P65	R:R:Q64	14.0149	4.74	No	No	0	6	7
36	R:R:E128	R:R:F142	32.958	12.83	No	No	0	9	6
37	R:R:F142	R:R:I131	26.6861	5.02	No	Yes	0	6	5
38	R:R:I131	R:R:P136	21.248	8.47	Yes	No	3	5	8
39	R:R:P136	R:R:Y130	19.9522	12.52	No	Yes	3	8	8
40	R:R:C134	R:R:Y130	13.0961	6.72	No	Yes	0	7	8
41	R:R:C134	R:R:I133	10.3877	3.27	No	No	0	7	8
42	R:R:A147	R:R:P65	11.2321	1.87	No	No	0	7	6
43	R:R:M251	R:R:Y217	14.0733	10.78	No	Yes	0	8	9
44	R:R:M251	R:R:Y300	10.2655	11.97	No	Yes	0	8	9
45	R:R:F255	R:R:Y259	18.1413	14.44	Yes	Yes	0	9	8
46	R:R:C258	R:R:Y259	12.2995	12.1	No	Yes	0	8	8
47	R:R:C258	R:R:Y295	11.1577	5.38	No	Yes	0	8	6
48	R:R:K290	R:R:S84	37.7164	3.06	Yes	Yes	0	7	6
49	R:R:F204	R:R:W120	84.0096	8.02	Yes	Yes	5	4	5
50	R:R:F204	R:R:V161	33.043	3.93	Yes	Yes	5	4	5
51	R:R:L201	R:R:V161	31.1843	4.47	No	Yes	0	4	5
52	R:R:L201	R:R:Y197	30.2602	10.55	No	Yes	0	4	6
53	R:R:P165	R:R:Y197	22.6075	9.74	No	Yes	0	4	6
54	R:R:F172	R:R:P165	30.786	13	Yes	No	0	5	4
55	R:R:F109	R:R:F172	33.8768	4.29	Yes	Yes	2	6	5
56	R:R:F109	R:R:L110	17.4881	3.65	Yes	No	0	6	4
57	R:R:F200	R:R:F204	50.6426	7.5	No	Yes	5	4	4
58	R:R:F200	R:R:W169	49.8301	8.02	No	Yes	0	4	5
59	R:R:W169	R:R:Y197	30.6585	10.61	Yes	Yes	0	5	6
60	R:R:P164	R:R:W169	14.8593	6.76	No	Yes	0	7	5
61	R:R:P164	R:R:P165	11.6091	5.84	No	No	0	7	4
62	R:R:P183	R:R:Y197	33.9618	4.17	Yes	Yes	0	4	6
63	R:R:F172	R:R:P183	20.4833	5.78	Yes	Yes	2	5	4
64	R:R:Q107	R:R:S84	31.8906	5.78	Yes	Yes	0	8	6
65	R:R:P87	R:R:Q107	10.1593	6.32	No	Yes	0	5	8
66	R:R:C181	R:R:Q107	18.1413	3.05	No	Yes	0	9	8
67	R:R:F109	R:R:V113	11.2852	7.87	Yes	No	2	6	5
68	R:R:C181	R:R:P174	14.9602	5.65	No	No	0	9	3
69	R:R:I173	R:R:P174	13.3245	3.39	No	No	0	2	3
70	L:L:?1	R:R:Y262	21.572	18.71	Yes	Yes	1	0	7
71	R:R:W185	R:R:Y262	14.291	11.58	Yes	Yes	1	6	7
72	R:R:F202	R:R:F206	11.2958	4.29	Yes	Yes	0	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F206	4.05	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y262	18.71	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S286	3.99	1	Yes	No	0	6	0	1
L:L:?1	R:R:S289	7.99	1	Yes	No	0	8	0	1
L:L:?1	R:R:K290	7.5	1	Yes	Yes	0	7	0	1
R:R:F37	R:R:K290	4.96	0	No	Yes	5	7	2	1
R:R:K290	R:R:M38	8.64	1	Yes	No	7	7	1	2
R:R:W185	R:R:Y262	11.58	1	Yes	Yes	6	7	2	1
R:R:P285	R:R:W185	4.05	1	Yes	Yes	5	6	2	2
R:R:F202	R:R:F206	4.29	0	Yes	Yes	5	8	2	1
R:R:F206	R:R:V260	3.93	0	Yes	No	8	6	1	2
R:R:A263	R:R:F206	8.32	0	No	Yes	7	8	2	1
R:R:P285	R:R:Y262	9.74	1	Yes	Yes	5	7	2	1
R:R:S286	R:R:Y262	5.09	1	No	Yes	6	7	1	1
R:R:S289	R:R:Y262	5.09	1	No	Yes	8	7	1	1
R:R:K290	R:R:S286	6.12	1	Yes	No	7	6	1	1
R:R:K290	R:R:S84	3.06	1	Yes	Yes	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Y02_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.93
Number of Linked Nodes	237
Number of Links	261
Number of Hubs	35
Number of Links mediated by Hubs	138
Number of Communities	9
Number of Nodes involved in Communities	45
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	40266
Length Of Smallest Path	3
Average Path Length	15.1604
Length of Longest Path	31
Minimum Path Strength	1.635
Average Path Strength	6.8697
Maximum Path Strength	16.425
Minimum Path Correlation	0.7
Average Path Correlation	0.914153
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	40.5884
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.2115
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • response to light stimulus • response to stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular process • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • multicellular organismal process • sensory perception of light stimulus • system process • sensory perception • nervous system process • visual perception • phototransduction • detection of light stimulus • detection of external stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • response to external stimulus • detection of abiotic stimulus • cell communication • detection of stimulus • signal transduction • G protein-coupled receptor signaling pathway • response to UV • cellular response to UV-A • cellular response to UV • response to UV-A • cellular anatomical structure • photoreceptor inner segment • membrane-bounded organelle • non-motile cilium • membrane • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle
Gene Ontology	Cellular Component	• cellular anatomical structure • photoreceptor inner segment • membrane-bounded organelle • non-motile cilium • membrane • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • cone photoreceptor outer segment • intracellular anatomical structure • perinuclear region of cytoplasm • cytoplasm • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • synapse • cell junction • G-protein beta-subunit binding
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	RET
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	RET
Name	RETINAL
Synonyms
Identifier
Formula	C20 H28 O
Molecular Weight	284.436
SMILES
PubChem	638015
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P03999
Sequence	>8Y02_nogp_Chain_R Q A A F M G T V F L I G F P L N A M V L V A T L R Y K K L R Q P L N Y I L V N V S F G G F L L C I F S V F P V F V A F V F G R H V C A L G F L G T V A G L V T G W S L A F L A F E R Y I V I C K P F G N F R F S S K H A L T V V L A T W T I G I G V S I P P F F G W S R F I P E G L Q C S C G P D W Y T K Y R S E S Y T W F L F I F C F I V P L S L I C F S Y T Q L L R A L K A V A A Q Q Q E S A T T Q K A E R E V S R M V V V M V G S F C V C Y V P Y A A F A M Y M V I P S F F S K S A C I Y N P I I Y C F M N K Q F Q A C I M Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Y02	A	Sensory	Opsins	OPN1SW	Homo sapiens	Retinal	-	Gi1/β1/γ2	2.61	2025-06-11	To be published
	8Y02 (No Gprot)	A	Sensory	Opsins	OPN1SW	Homo sapiens	Retinal	-		2.61	2025-06-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Y02_nogp.zip

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