psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C24	R:R:C274	7.28	No	No	0	9	8
2	R:R:E27	R:R:T25	5.64	No	No	0	2	5
3	R:R:E27	R:R:N278	9.2	No	No	0	2	3
4	R:R:H281	R:R:N28	5.1	Yes	No	0	4	3
5	R:R:L31	R:R:Y35	4.69	No	No	0	3	5
6	R:R:K32	R:R:L36	4.23	Yes	Yes	2	3	6
7	R:R:K32	R:R:Y93	3.58	Yes	Yes	2	3	5
8	R:R:H281	R:R:K32	3.93	Yes	Yes	2	4	3
9	R:R:I285	R:R:K32	4.36	No	Yes	2	5	3
10	R:R:H34	R:R:Y35	10.89	No	No	0	2	5
11	R:R:L36	R:R:Y40	7.03	Yes	No	0	6	7
12	R:R:L36	R:R:Y93	4.69	Yes	Yes	2	6	5
13	R:R:I285	R:R:L36	4.28	No	Yes	2	5	6
14	R:R:F296	R:R:I43	6.28	Yes	No	0	8	7
15	R:R:F44	R:R:F48	7.5	No	Yes	0	7	6
16	R:R:F44	R:R:L86	3.65	No	No	0	7	8
17	R:R:F44	R:R:P87	7.22	No	No	0	7	9
18	R:R:F296	R:R:V46	5.24	Yes	No	0	8	6
19	R:R:F48	R:R:L80	9.74	Yes	No	0	6	7
20	R:R:D79	R:R:N51	6.73	No	No	0	9	9
21	R:R:L299	R:R:N51	4.12	No	No	0	9	9
22	R:R:V54	R:R:Y58	5.05	No	Yes	0	8	7
23	R:R:V303	R:R:V54	4.81	No	No	0	6	8
24	R:R:F309	R:R:T57	7.78	Yes	No	0	8	7
25	R:R:T69	R:R:Y58	3.75	No	Yes	0	7	7
26	R:R:M72	R:R:Y58	5.99	No	Yes	0	8	7
27	R:R:L73	R:R:Y58	3.52	No	Yes	0	5	7
28	R:R:K61	R:R:T316	6.01	No	No	0	5	5
29	R:R:L73	R:R:W65	4.56	No	No	0	5	6
30	R:R:A150	R:R:I70	4.87	No	No	0	7	7
31	R:R:F127	R:R:I71	6.28	Yes	No	0	9	7
32	R:R:F130	R:R:I71	6.28	Yes	No	0	8	7
33	R:R:F127	R:R:M72	6.22	Yes	No	3	9	8
34	R:R:M72	R:R:Y302	4.79	No	Yes	3	8	9
35	R:R:F123	R:R:N74	9.67	Yes	No	1	8	9
36	R:R:C154	R:R:N74	9.45	No	No	1	7	9
37	R:R:N74	R:R:W158	4.52	No	Yes	1	9	9
38	R:R:N116	R:R:T78	5.85	Yes	Yes	0	8	8
39	R:R:S119	R:R:T78	6.4	No	Yes	1	7	8
40	R:R:T78	R:R:W158	6.06	Yes	Yes	1	8	9
41	R:R:D79	R:R:T295	7.23	No	No	0	9	9
42	R:R:D79	R:R:N298	4.04	No	No	0	9	9
43	R:R:L81	R:R:N116	6.87	No	Yes	0	7	8
44	R:R:F113	R:R:Y82	12.38	No	No	0	6	7
45	R:R:N116	R:R:Y82	4.65	Yes	No	0	8	7
46	R:R:I109	R:R:S85	4.64	Yes	No	0	5	7
47	R:R:F101	R:R:F88	8.57	No	No	0	7	6
48	R:R:F88	R:R:I109	10.05	No	Yes	0	6	5
49	R:R:L89	R:R:Y93	3.52	No	Yes	0	6	5
50	R:R:L89	R:R:R110	6.07	No	No	0	6	5
51	R:R:H91	R:R:S95	8.37	No	No	0	5	3
52	R:R:H91	R:R:I100	5.3	No	No	0	5	1
53	R:R:F101	R:R:H91	10.18	No	No	0	7	5
54	R:R:Y92	R:R:Y93	9.93	No	Yes	0	5	5
55	R:R:E97	R:R:Y92	12.35	No	No	0	4	5
56	R:R:W99	R:R:Y92	5.79	Yes	No	0	9	5
57	R:R:E97	R:R:R177	4.65	No	No	5	4	3
58	R:R:E97	R:R:R180	10.47	No	Yes	5	4	2
59	R:R:N98	R:R:R180	6.03	No	Yes	0	4	2
60	R:R:F101	R:R:W99	13.03	No	Yes	0	7	9
61	R:R:C106	R:R:W99	6.53	No	Yes	6	9	9
62	R:R:I109	R:R:W99	4.7	Yes	Yes	0	5	9
63	R:R:C183	R:R:W99	6.53	No	Yes	6	9	9
64	R:R:D103	R:R:S174	4.42	No	No	0	3	5
65	R:R:F104	R:R:F108	5.36	No	No	0	3	5
66	R:R:I109	R:R:M105	4.37	Yes	No	0	5	6
67	R:R:C106	R:R:C183	7.28	No	No	6	9	9
68	R:R:C183	R:R:R110	4.18	No	No	0	9	5
69	R:R:D185	R:R:R110	4.76	Yes	No	0	5	5
70	R:R:F111	R:R:F115	5.36	No	Yes	1	5	5
71	R:R:F111	R:R:V165	6.55	No	No	1	5	7
72	R:R:F111	R:R:T169	5.19	No	No	0	5	4
73	R:R:N116	R:R:S112	4.47	Yes	No	0	8	4
74	R:R:F113	R:R:H114	7.92	No	No	0	6	6
75	R:R:H114	R:R:M168	9.19	No	Yes	0	6	4
76	R:R:F115	R:R:N116	3.62	Yes	Yes	0	5	8
77	R:R:F115	R:R:W158	5.01	Yes	Yes	1	5	9
78	R:R:F115	R:R:S161	3.96	Yes	No	0	5	8
79	R:R:F115	R:R:L162	4.87	Yes	No	0	5	4
80	R:R:F115	R:R:V165	6.55	Yes	No	1	5	7
81	R:R:L117	R:R:Y118	4.69	No	Yes	0	8	7
82	R:R:F254	R:R:L117	3.65	Yes	No	0	8	8
83	R:R:L202	R:R:Y118	5.86	No	Yes	0	5	7
84	R:R:T206	R:R:Y118	7.49	No	Yes	0	5	7
85	R:R:H258	R:R:Y118	6.53	Yes	Yes	0	8	7
86	R:R:R261	R:R:Y118	5.14	Yes	Yes	0	5	7
87	R:R:S119	R:R:W158	4.94	No	Yes	1	7	9
88	R:R:F254	R:R:I121	13.82	Yes	No	0	8	8
89	R:R:L122	R:R:V157	4.47	No	No	0	6	7
90	R:R:L122	W:W:?1	5.26	No	Yes	0	6	0
91	R:R:C154	R:R:F123	5.59	No	Yes	1	7	8
92	R:R:F123	R:R:V157	10.49	Yes	No	0	8	7
93	R:R:F123	R:R:W158	10.02	Yes	Yes	1	8	9
94	R:R:F250	R:R:L124	3.65	No	Yes	0	9	8
95	R:R:L124	R:R:N298	8.24	Yes	No	0	8	9
96	R:R:L124	R:R:Y302	4.69	Yes	Yes	0	8	9
97	R:R:P210	R:R:T125	6.99	No	No	0	8	7
98	R:R:C126	R:R:F130	4.19	No	Yes	0	7	8
99	R:R:F127	R:R:R131	11.76	Yes	No	3	9	9
100	R:R:F127	R:R:Y302	4.13	Yes	Yes	3	9	9
101	R:R:S128	R:R:V214	4.85	No	No	0	9	8
102	R:R:S128	R:R:Y218	6.36	No	Yes	0	9	8
103	R:R:F130	R:R:I144	10.05	Yes	No	0	8	4
104	R:R:R131	R:R:Y218	6.17	No	Yes	0	9	8
105	R:R:R131	R:R:Y302	6.17	No	Yes	3	9	9
106	R:R:I136	R:R:Y132	14.51	Yes	No	0	8	8
107	R:R:C217	R:R:Y132	9.41	No	No	0	7	8
108	R:R:T220	R:R:Y132	6.24	No	No	0	3	8
109	R:R:C133	R:R:I144	4.91	No	No	0	5	4
110	R:R:H145	R:R:V134	4.15	No	No	0	7	8
111	R:R:H137	R:R:I136	7.95	No	Yes	0	7	8
112	R:R:I136	R:R:T224	4.56	Yes	No	0	8	5
113	R:R:H137	R:R:S140	4.18	No	No	0	7	5
114	R:R:C141	W:W:?1	6.03	No	Yes	0	6	0
115	R:R:I144	W:W:?1	5.43	No	Yes	0	4	0
116	R:R:R148	W:W:?1	6.16	No	Yes	0	4	0
117	R:R:C149	W:W:?1	16.09	No	Yes	0	3	0
118	R:R:V152	W:W:?1	16.99	No	Yes	0	2	0
119	R:R:I160	W:W:?1	3.62	No	Yes	0	4	0
120	R:R:P167	R:R:Y198	6.95	No	No	0	8	5
121	R:R:L186	R:R:M168	7.07	No	Yes	0	3	4
122	R:R:M168	R:R:Y198	4.79	Yes	No	0	4	5
123	R:R:F170	R:R:L171	4.87	No	No	0	4	5
124	R:R:E191	R:R:L171	5.3	Yes	No	0	3	5
125	R:R:S189	R:R:T173	6.4	No	Yes	4	4	4
126	R:R:D190	R:R:T173	7.23	No	Yes	4	3	4
127	R:R:E191	R:R:T173	4.23	Yes	Yes	4	3	4
128	R:R:R177	R:R:R180	18.13	No	Yes	5	3	2
129	R:R:A182	R:R:R177	4.15	No	No	0	3	3
130	R:R:N179	R:R:T178	4.39	No	No	0	5	1
131	R:R:N179	R:R:R180	10.85	No	Yes	0	5	2
132	R:R:A182	R:R:L184	4.73	No	No	0	3	4
133	R:R:L184	R:R:S188	7.51	No	No	0	4	5
134	R:R:D185	R:R:T187	7.23	Yes	No	0	5	4
135	R:R:D185	R:R:S188	4.42	Yes	No	0	5	5
136	R:R:D185	R:R:R288	5.96	Yes	No	0	5	6
137	R:R:R264	R:R:T187	11.64	No	No	0	5	4
138	R:R:T187	R:R:Y284	11.24	No	Yes	0	4	5
139	R:R:E191	R:R:S189	4.31	Yes	No	4	3	4
140	R:R:D190	R:R:E191	12.99	No	Yes	4	3	3
141	R:R:L192	R:R:R268	9.72	No	No	0	2	4
142	R:R:L192	R:R:L269	11.07	No	No	0	2	2
143	R:R:N193	R:R:W197	5.65	No	No	0	1	3
144	R:R:K196	R:R:W197	5.8	Yes	No	0	3	3
145	R:R:E266	R:R:K196	8.1	No	Yes	0	4	3
146	R:R:L202	R:R:Y198	4.69	No	No	0	5	5
147	R:R:N199	R:R:R261	9.64	No	Yes	0	6	5
148	R:R:I265	R:R:N199	5.66	No	No	0	5	6
149	R:R:H258	R:R:T203	4.11	Yes	No	0	8	4
150	R:R:T205	R:R:T206	4.71	No	No	0	4	5
151	R:R:T205	W:W:?1	5.6	No	Yes	0	4	0
152	R:R:F207	R:R:L211	6.09	No	No	0	8	6
153	R:R:F207	R:R:L255	3.65	No	No	0	8	5
154	R:R:F207	R:R:H258	22.63	No	Yes	0	8	8
155	R:R:L209	W:W:?1	3.51	No	Yes	0	5	0
156	R:R:F250	R:R:L211	3.65	No	No	0	9	6
157	R:R:L211	R:R:Y251	10.55	No	No	0	6	6
158	R:R:T215	R:R:Y251	6.24	No	No	0	4	6
159	R:R:T243	R:R:Y218	4.99	No	Yes	0	8	8
160	R:R:L247	R:R:Y218	4.69	No	Yes	0	8	8
161	R:R:I222	R:R:R240	3.76	No	No	0	4	6
162	R:R:I222	R:R:T243	6.08	No	No	0	4	8
163	R:R:H223	R:R:H227	13.14	No	No	0	2	4
164	R:R:H227	R:R:T226	5.48	No	No	0	4	4
165	R:R:D232	R:R:Q230	3.92	No	No	0	5	3
166	R:R:Q230	R:R:S233	5.78	No	No	0	3	2
167	R:R:Q237	R:R:R241	5.84	No	No	0	5	5
168	R:R:L242	R:R:V305	4.47	No	No	0	8	6
169	R:R:L246	R:R:L301	4.15	No	Yes	0	8	7
170	R:R:L246	R:R:Y302	10.55	No	Yes	0	8	9
171	R:R:F250	R:R:F254	9.65	No	Yes	0	9	8
172	R:R:C253	R:R:N294	11.02	No	No	0	8	9
173	R:R:F254	R:R:N294	10.87	Yes	No	0	8	9
174	R:R:I259	R:R:L255	5.71	No	No	0	6	5
175	R:R:F257	R:R:H258	4.53	Yes	Yes	0	7	8
176	R:R:F257	R:R:R261	5.34	Yes	Yes	7	7	5
177	R:R:F257	R:R:Y284	7.22	Yes	Yes	7	7	5
178	R:R:F257	R:R:S287	3.96	Yes	No	0	7	7
179	R:R:A283	R:R:L260	4.73	No	No	0	5	5
180	R:R:L260	R:R:S287	4.5	No	No	0	5	7
181	R:R:R261	R:R:Y284	5.14	Yes	Yes	7	5	5
182	R:R:R264	R:R:R268	7.46	No	No	0	5	4
183	R:R:H281	R:R:R264	15.8	Yes	No	0	4	5
184	R:R:I280	R:R:S267	4.64	No	No	0	5	5
185	R:R:I272	R:R:L270	4.28	Yes	No	0	1	3
186	R:R:E277	R:R:I272	8.2	No	Yes	0	3	1
187	R:R:S273	R:R:S275	4.89	No	No	0	4	1
188	R:R:C274	R:R:E277	6.08	No	No	0	8	3
189	R:R:I276	R:R:Q279	4.12	No	No	0	3	3
190	R:R:H281	R:R:I285	7.95	Yes	No	2	4	5
191	R:R:R288	R:R:Y284	12.35	No	Yes	0	6	5
192	R:R:F296	R:R:L293	4.87	Yes	No	0	8	5
193	R:R:N294	R:R:N298	6.81	No	No	0	9	9
194	R:R:F309	R:R:V303	9.18	Yes	No	0	8	6
195	R:R:D307	R:R:Q310	5.22	No	No	0	4	7
196	R:R:D307	R:R:Q311	5.22	No	No	0	4	5
197	R:R:F309	R:R:V313	5.24	Yes	No	0	8	6
198	R:R:C319	R:R:R318	5.57	No	No	0	9	4
199	R:R:C217	R:R:S128	3.44	No	No	0	7	9
200	R:R:I29	R:R:P30	3.39	No	No	0	3	1
201	R:R:I121	R:R:P210	3.39	No	No	0	8	8
202	R:R:I166	R:R:P167	3.39	No	No	0	4	8
203	R:R:A76	R:R:I55	3.25	No	No	0	9	7
204	R:R:C77	R:R:L73	3.17	No	No	0	5	5
205	R:R:I195	R:R:S189	3.1	No	No	0	4	4
206	R:R:I135	R:R:V134	3.07	No	No	0	8	8
207	R:R:I160	R:R:V156	3.07	No	No	0	4	4
208	R:R:K107	R:R:S174	3.06	No	No	0	7	5
209	R:R:K146	R:R:S143	3.06	No	No	0	6	4
210	R:R:K236	R:R:S233	3.06	No	No	0	5	2
211	R:R:I70	R:R:T147	3.04	No	No	0	7	2
212	R:R:I213	R:R:T125	3.04	No	No	0	7	7
213	R:R:K66	R:R:T69	3	No	No	0	7	7
214	R:R:N176	R:R:S181	2.98	No	No	0	1	5
215	R:R:L216	R:R:V212	2.98	No	No	0	4	3
216	R:R:L171	R:R:T194	2.95	No	No	0	5	3
217	R:R:I39	R:R:I43	2.94	No	No	0	5	7
218	R:R:I55	R:R:I59	2.94	No	No	0	7	4
219	R:R:I129	R:R:I213	2.94	No	No	0	6	7
220	R:R:I195	R:R:I265	2.94	No	No	0	4	5
221	R:R:I263	R:R:I280	2.94	No	No	0	5	5
222	R:R:I272	R:R:I276	2.94	Yes	No	0	1	3
223	R:R:I172	R:R:M168	2.92	No	Yes	0	4	4
224	R:R:I172	R:R:K107	2.91	No	No	0	4	7
225	R:R:F48	R:R:P49	2.89	Yes	No	0	6	4
226	R:R:P289	R:R:R288	2.88	No	No	0	6	6
227	R:R:I221	R:R:L225	2.85	No	No	0	8	8
228	R:R:K196	R:R:L269	2.82	Yes	No	0	3	2
229	R:R:K236	R:R:L225	2.82	No	No	0	5	8
230	R:R:L124	R:R:L75	2.77	Yes	No	0	8	9
231	R:R:L83	R:R:L86	2.77	No	No	0	6	8
232	R:R:A153	R:R:F130	2.77	No	Yes	0	6	8
233	R:R:L245	R:R:L301	2.77	No	Yes	0	5	7
234	R:R:A291	R:R:F257	2.77	No	Yes	0	8	7
235	R:R:L80	R:R:N51	2.75	No	No	0	7	9
236	R:R:F130	R:R:S67	2.64	Yes	No	0	8	6
237	R:R:F127	R:R:S68	2.64	Yes	No	0	9	8
238	R:R:R240	R:R:T226	2.59	No	No	0	6	4
239	R:R:F60	R:R:I59	2.51	No	No	0	4	4
240	R:R:F108	R:R:I109	2.51	No	Yes	0	5	5
241	R:R:I244	R:R:R240	2.51	No	No	0	5	6
242	R:R:I90	R:R:Y40	2.42	No	No	0	7	7
243	R:R:I221	R:R:Y218	2.42	No	Yes	0	8	8
244	R:R:M62	R:R:Y58	2.39	No	Yes	0	6	7
245	R:R:P37	R:R:V38	1.77	No	No	0	5	5
246	R:R:G41	R:R:I90	1.76	No	No	0	3	7
247	R:R:G96	R:R:M33	1.75	No	No	0	3	4
248	R:R:G47	R:R:L83	1.71	No	No	0	8	6
249	R:R:A150	R:R:S67	1.71	No	No	0	7	6
250	R:R:A76	R:R:V54	1.7	No	No	0	9	8
251	R:R:I90	R:R:P37	1.69	No	No	0	7	5
252	R:R:I39	R:R:P289	1.69	No	No	0	5	6
253	R:R:A312	R:R:T57	1.68	No	No	0	5	7
254	R:R:M139	R:R:P138	1.68	No	No	0	5	8
255	R:R:A164	R:R:T206	1.68	No	No	0	4	5
256	R:R:L255	R:R:P256	1.64	No	No	0	5	9
257	R:R:A292	R:R:I43	1.62	No	No	0	7	7
258	R:R:S322	R:R:V321	1.62	No	No	0	4	3
259	R:R:A312	R:R:K61	1.61	No	No	0	5	5
260	R:R:S120	R:R:T78	1.6	No	Yes	0	9	8
261	R:R:T57	R:R:V53	1.59	No	No	0	7	6
262	R:R:G228	R:R:H227	1.59	No	No	0	6	4
263	R:R:A239	R:R:L225	1.58	No	No	0	7	8
264	R:R:A249	R:R:L301	1.58	No	Yes	0	6	7
265	R:R:T173	R:R:T175	1.57	Yes	No	0	4	3
266	R:R:T215	R:R:T219	1.57	No	No	0	4	4
267	R:R:I272	R:R:S267	1.55	Yes	No	0	1	5
268	R:R:I42	R:R:V38	1.54	No	No	0	5	5
269	R:R:I42	R:R:V46	1.54	No	No	0	5	6
270	R:R:I70	R:R:V151	1.54	No	No	0	7	4
271	R:R:I159	R:R:V163	1.54	No	No	0	4	4
272	R:R:H137	R:R:P138	1.53	No	No	0	7	8
273	R:R:I201	R:R:T205	1.52	No	No	0	4	4
274	R:R:F296	R:R:G297	1.51	Yes	No	0	8	7
275	R:R:N199	R:R:V262	1.48	No	No	0	6	5
276	R:R:I135	R:R:I136	1.47	No	Yes	0	8	8
277	R:R:I135	R:R:I221	1.47	No	No	0	8	8
278	R:R:I259	R:R:I263	1.47	No	No	0	6	5
279	R:R:N176	R:R:T178	1.46	No	No	0	1	1
280	R:R:P64	R:R:R63	1.44	No	No	0	6	6
281	R:R:K196	R:R:L200	1.41	Yes	No	0	3	4
282	R:R:M62	R:R:N308	1.4	No	No	0	6	6
283	R:R:L242	R:R:L301	1.38	No	Yes	0	8	7
284	R:R:L290	R:R:L293	1.38	No	No	0	8	5
285	R:R:D26	R:R:N28	1.35	No	No	0	4	3
286	R:R:E282	R:R:L31	1.33	No	No	0	2	3
287	R:R:N278	R:R:Q279	1.32	No	No	0	3	3
288	R:R:F309	R:R:S306	1.32	Yes	No	0	8	8
289	R:R:R318	R:R:S315	1.32	No	No	0	4	5
290	R:R:F48	R:R:T84	1.3	Yes	No	0	6	5
291	R:R:E282	R:R:Q279	1.27	No	No	0	2	3
292	R:R:F142	R:R:H145	1.13	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K32	4.025	4	2	3
2	R:R:L36	5.0575	4	2	6
3	R:R:F48	5.3575	4	0	6
4	R:R:Y58	4.14	5	0	7
5	R:R:T78	4.9775	4	1	8
6	R:R:Y93	5.43	4	2	5
7	R:R:W99	7.316	5	6	9
8	R:R:I109	5.254	5	0	5
9	R:R:F115	4.895	6	1	5
10	R:R:N116	5.092	5	0	8
11	R:R:Y118	5.942	5	0	7
12	R:R:F123	8.9425	4	1	8
13	R:R:L124	4.8375	4	0	8
14	R:R:F127	6.206	5	3	9
15	R:R:F130	5.186	5	0	8
16	R:R:I136	7.1225	4	0	8
17	R:R:W158	6.11	5	1	9
18	R:R:M168	5.9925	4	0	4
19	R:R:T173	4.8575	4	4	4
20	R:R:R180	11.37	4	5	2
21	R:R:D185	5.5925	4	0	5
22	R:R:E191	6.7075	4	4	3
23	R:R:K196	4.5325	4	0	3
24	R:R:Y218	4.926	5	0	8
25	R:R:F254	9.4975	4	0	8
26	R:R:F257	4.764	5	7	7
27	R:R:H258	9.45	4	0	8
28	R:R:R261	6.315	4	7	5
29	R:R:I272	4.2425	4	0	1
30	R:R:H281	8.195	4	2	4
31	R:R:Y284	8.9875	4	7	5
32	R:R:F296	4.475	4	0	8
33	R:R:L301	2.47	4	0	7
34	R:R:Y302	6.066	5	3	9
35	R:R:F309	5.88	4	0	8
36	W:W:?1	7.63222	9	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I272	R:R:I276	14.0862	2.94	Yes	No	0	1	3
2	R:R:I276	R:R:Q279	12.5463	4.12	No	No	0	3	3
3	R:R:I272	R:R:S267	21.6376	1.55	Yes	No	0	1	5
4	R:R:I280	R:R:S267	23.1183	4.64	No	No	0	5	5
5	R:R:I263	R:R:I280	24.5891	2.94	No	No	0	5	5
6	R:R:I259	R:R:I263	26.05	1.47	No	No	0	6	5
7	R:R:I259	R:R:L255	27.5011	5.71	No	No	0	6	5
8	R:R:F207	R:R:L255	30.3736	3.65	No	No	0	8	5
9	R:R:F207	R:R:H258	63.294	22.63	No	Yes	0	8	8
10	R:R:F257	R:R:H258	56.2953	4.53	Yes	Yes	0	7	8
11	R:R:F257	R:R:Y284	52.2334	7.22	Yes	Yes	7	7	5
12	R:R:T187	R:R:Y284	80.8499	11.24	No	Yes	0	4	5
13	R:R:R264	R:R:T187	37.8905	11.64	No	No	0	5	4
14	R:R:H281	R:R:R264	25.9415	15.8	Yes	No	0	4	5
15	R:R:H281	R:R:K32	13.8246	3.93	Yes	Yes	2	4	3
16	R:R:D185	R:R:T187	45.2692	7.23	Yes	No	0	5	4
17	R:R:D185	R:R:R110	57.2973	4.76	Yes	No	0	5	5
18	R:R:L89	R:R:R110	11.0508	6.07	No	No	0	6	5
19	R:R:R288	R:R:Y284	59.7897	12.35	No	Yes	0	6	5
20	R:R:D185	R:R:R288	45.6394	5.96	Yes	No	0	5	6
21	R:R:L36	R:R:Y40	12.719	7.03	Yes	No	0	6	7
22	R:R:P289	R:R:R288	17.2153	2.88	No	No	0	6	6
23	R:R:I39	R:R:P289	15.6113	1.69	No	No	0	5	6
24	R:R:I39	R:R:I43	14.18	2.94	No	No	0	5	7
25	R:R:F296	R:R:I43	10.9718	6.28	Yes	No	0	8	7
26	R:R:F207	R:R:L211	52.7565	6.09	No	No	0	8	6
27	R:R:F250	R:R:L211	50.4862	3.65	No	No	0	9	6
28	R:R:F250	R:R:L124	96.5944	3.65	No	Yes	0	9	8
29	R:R:L124	R:R:N298	10.0242	8.24	Yes	No	0	8	9
30	R:R:D79	R:R:N298	21.1046	4.04	No	No	0	9	9
31	R:R:D79	R:R:N51	17.9655	6.73	No	No	0	9	9
32	R:R:L80	R:R:N51	14.787	2.75	No	No	0	7	9
33	R:R:F48	R:R:L80	13.183	9.74	Yes	No	0	6	7
34	R:R:L124	R:R:Y302	100	4.69	Yes	Yes	0	8	9
35	R:R:M72	R:R:Y302	38.2064	4.79	No	Yes	3	8	9
36	R:R:M72	R:R:Y58	45.2199	5.99	No	Yes	0	8	7
37	R:R:V54	R:R:Y58	29.4408	5.05	No	Yes	0	8	7
38	R:R:V303	R:R:V54	19.002	4.81	No	No	0	6	8
39	R:R:F309	R:R:V303	16.8847	9.18	Yes	No	0	8	6
40	R:R:F309	R:R:T57	10.6658	7.78	Yes	No	0	8	7
41	R:R:F130	R:R:I71	18.9675	6.28	Yes	No	0	8	7
42	R:R:F127	R:R:I71	18.7207	6.28	Yes	No	0	9	7
43	R:R:F130	R:R:I144	22.4717	10.05	Yes	No	0	8	4
44	R:R:I144	W:W:?1	23.5625	5.43	No	Yes	0	4	0
45	R:R:T205	W:W:?1	32.0912	5.6	No	Yes	0	4	0
46	R:R:T205	R:R:T206	33.0882	4.71	No	No	0	4	5
47	R:R:T206	R:R:Y118	34.7071	7.49	No	Yes	0	5	7
48	R:R:H258	R:R:Y118	12.3933	6.53	Yes	Yes	0	8	7
49	R:R:L122	W:W:?1	24.9297	5.26	No	Yes	0	6	0
50	R:R:L122	R:R:V157	23.6267	4.47	No	No	0	6	7
51	R:R:F123	R:R:V157	22.3385	10.49	Yes	No	0	8	7
52	R:R:F123	R:R:W158	18.4098	10.02	Yes	Yes	1	8	9
53	R:R:L202	R:R:Y118	27.4962	5.86	No	Yes	0	5	7
54	R:R:L202	R:R:Y198	26.3018	4.69	No	No	0	5	5
55	R:R:M168	R:R:Y198	22.6445	4.79	Yes	No	0	4	5
56	R:R:H114	R:R:M168	15.1819	9.19	No	Yes	0	6	4
57	R:R:F113	R:R:H114	13.9233	7.92	No	No	0	6	6
58	R:R:F113	R:R:Y82	12.8424	12.38	No	No	0	6	7
59	R:R:N116	R:R:Y82	12.4476	4.65	Yes	No	0	8	7
60	R:R:C183	R:R:R110	44.1538	4.18	No	No	0	9	5
61	R:R:C183	R:R:W99	38.9764	6.53	No	Yes	6	9	9
62	R:R:I109	R:R:W99	17.8965	4.7	Yes	Yes	0	5	9
63	R:R:F101	R:R:W99	14.9499	13.03	No	Yes	0	7	9
64	R:R:Y92	R:R:Y93	10.9768	9.93	No	Yes	0	5	5
65	R:R:D185	R:R:S188	30.3539	4.42	Yes	No	0	5	5
66	R:R:L184	R:R:S188	27.4863	7.51	No	No	0	4	5
67	R:R:A182	R:R:L184	24.7174	4.73	No	No	0	3	4
68	R:R:A182	R:R:R177	22.1016	4.15	No	No	0	3	3
69	R:R:R177	R:R:R180	16.3714	18.13	No	Yes	5	3	2
70	R:R:F115	R:R:W158	11.0409	5.01	Yes	Yes	1	5	9
71	R:R:L117	R:R:Y118	66.8427	4.69	No	Yes	0	8	7
72	R:R:F250	R:R:F254	49.2473	9.65	No	Yes	0	9	8
73	R:R:R261	R:R:Y118	95.0397	5.14	Yes	Yes	0	5	7
74	R:R:R131	R:R:Y302	53.5808	6.17	No	Yes	3	9	9
75	R:R:R131	R:R:Y218	63.2792	6.17	No	Yes	0	9	8
76	R:R:S128	R:R:Y218	10.3549	6.36	No	Yes	0	9	8
77	R:R:I221	R:R:Y218	34.633	2.42	No	Yes	0	8	8
78	R:R:I135	R:R:I221	20.8627	1.47	No	No	0	8	8
79	R:R:I135	R:R:I136	12.7042	1.47	No	Yes	0	8	8
80	R:R:N199	R:R:R261	20.5913	9.64	No	Yes	0	6	5
81	R:R:I265	R:R:N199	17.5312	5.66	No	No	0	5	6
82	R:R:I195	R:R:I265	15.9864	2.94	No	No	0	4	5
83	R:R:I195	R:R:S189	14.4317	3.1	No	No	0	4	4
84	R:R:N179	R:R:R180	11.801	10.85	No	Yes	0	5	2
85	R:R:R264	R:R:R268	13.9727	7.46	No	No	0	5	4
86	R:R:L192	R:R:R268	12.26	9.72	No	No	0	2	4
87	R:R:L192	R:R:L269	10.5375	11.07	No	No	0	2	2
88	R:R:T243	R:R:Y218	16.8945	4.99	No	Yes	0	8	8
89	R:R:I222	R:R:T243	14.8166	6.08	No	No	0	4	8
90	R:R:I222	R:R:R240	12.7289	3.76	No	No	0	4	6
91	R:R:I221	R:R:L225	12.492	2.85	No	No	0	8	8
92	R:R:L246	R:R:Y302	11.8454	10.55	No	Yes	0	8	9
93	R:R:F254	R:R:N294	15.4336	10.87	Yes	No	0	8	9
94	R:R:N294	R:R:N298	14.1701	6.81	No	No	0	9	9
95	R:R:F254	R:R:L117	66.2455	3.65	Yes	No	0	8	8
96	R:R:R261	R:R:Y284	87.8881	5.14	Yes	Yes	7	5	5
97	R:R:F127	R:R:R131	11.3519	11.76	Yes	No	3	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L122	R:R:V157	4.47	No	No	6	7	1	2
R:R:L122	W:W:?1	5.26	No	Yes	6	0	1	0
R:R:F130	R:R:I144	10.05	Yes	No	8	4	2	1
R:R:C133	R:R:I144	4.91	No	No	5	4	2	1
R:R:C141	W:W:?1	6.03	No	Yes	6	0	1	0
R:R:I144	W:W:?1	5.43	No	Yes	4	0	1	0
R:R:R148	W:W:?1	6.16	No	Yes	4	0	1	0
R:R:C149	W:W:?1	16.09	No	Yes	3	0	1	0
R:R:V152	W:W:?1	16.99	No	Yes	2	0	1	0
R:R:I160	W:W:?1	3.62	No	Yes	4	0	1	0
R:R:T205	R:R:T206	4.71	No	No	4	5	1	2
R:R:T205	W:W:?1	5.6	No	Yes	4	0	1	0
R:R:L209	W:W:?1	3.51	No	Yes	5	0	1	0
R:R:I160	R:R:V156	3.07	No	No	4	4	1	2
R:R:I201	R:R:T205	1.52	No	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YYX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.51
Number of Linked Nodes	277
Number of Links	292
Number of Hubs	36
Number of Links mediated by Hubs	143
Number of Communities	7
Number of Nodes involved in Communities	31
Number of Links involved in Communities	38

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	52184
Length Of Smallest Path	3
Average Path Length	14.3267
Length of Longest Path	28
Minimum Path Strength	1.295
Average Path Strength	6.15492
Maximum Path Strength	16.54
Minimum Path Correlation	0.7
Average Path Correlation	0.926763
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	45.2459
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.755
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96P68
Sequence	>8YYX_nogp_Chain_R N C T D E N I P L K M H Y L P V I Y G I I F L V G F P G N A V V I S T Y I F K M R P W K S S T I I M L N L A C T D L L Y L T S L P F L I H Y Y A S G E N W I F G D F M C K F I R F S F H F N L Y S S I L F L T C F S I F R Y C V I I H P M S C F S I H K T R C A V V A C A V V W I I S L V A V I P M T F L I T S T N R T N R S A C L D L T S S D E L N T I K W Y N L I L T A T T F C L P L V I V T L C Y T T I I H T L T H G L Q T D S C L K Q K A R R L T I L L L L A F Y V C F L P F H I L R V I R I E S R L L S I S C S I E N Q I H E A Y I V S R P L A A L N T F G N L L L Y V V V S D N F Q Q A V C S T V R C K V S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YYX	A	Alicarboxylic acid	Oxoglutarate	Oxoglutarate	Homo sapiens	-	Leukotriene e4	chim(Gi1-CtGq)/β1/γ2	2.84	2025-04-09	To be published
	8YYX (No Gprot)	A	Alicarboxylic acid	Oxoglutarate	Oxoglutarate	Homo sapiens	-	Leukotriene e4		2.84	2025-04-09	To be published
	8YYW	A	Alicarboxylic acid	Oxoglutarate	Oxoglutarate	Homo sapiens	α-ketoglutarate	α-ketoglutarate	chim(Gi1-CtGq)/β1/γ2	3.19	2025-04-09	To be published
	8YYW (No Gprot)	A	Alicarboxylic acid	Oxoglutarate	Oxoglutarate	Homo sapiens	α-ketoglutarate	α-ketoglutarate		3.19	2025-04-09	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8YYX_nogp.zip

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