psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G10	R:R:T9	5.46	No	No	0	4	2
2	R:R:G10	R:R:L14	3.42	No	No	0	4	4
3	R:R:F13	R:R:Y12	16.5	No	No	0	3	8
4	R:R:A18	R:R:E19	6.03	No	Yes	0	5	3
5	R:R:E19	R:R:W22	3.27	Yes	Yes	6	3	9
6	R:R:E19	R:R:Q236	8.92	Yes	No	6	3	1
7	R:R:E19	R:R:W237	6.54	Yes	Yes	6	3	8
8	R:R:G20	R:R:P21	4.06	No	No	0	4	4
9	R:R:G20	R:R:W22	9.85	No	Yes	0	4	9
10	R:R:W22	R:R:W237	13.12	Yes	Yes	6	9	8
11	R:R:P240	R:R:W22	10.81	No	Yes	0	8	9
12	R:R:E27	R:R:I24	5.47	No	No	0	9	8
13	R:R:C243	R:R:L26	4.76	No	Yes	0	8	5
14	R:R:I244	R:R:L26	5.71	No	Yes	0	8	5
15	R:R:L29	R:R:W251	3.42	No	Yes	0	4	6
16	R:R:L32	R:R:W251	6.83	No	Yes	0	5	6
17	R:R:F74	R:R:G33	9.03	Yes	No	9	9	9
18	R:R:G33	R:R:W251	4.22	No	Yes	9	9	6
19	R:R:T37	R:R:V70	3.17	No	No	0	6	8
20	R:R:L71	R:R:T37	5.9	No	No	0	5	6
21	R:R:L254	R:R:T37	7.37	No	No	0	5	6
22	R:R:L40	R:R:L67	4.15	No	No	0	8	8
23	R:R:F46	R:R:L42	7.31	No	No	0	4	4
24	R:R:F44	R:R:L47	7.31	No	No	0	6	7
25	R:R:F44	R:R:Q63	5.86	No	No	0	6	6
26	R:R:F44	R:R:L262	4.87	No	No	0	6	4
27	R:R:K50	R:R:L47	5.64	No	No	0	6	7
28	R:R:I51	R:R:L47	4.28	No	No	0	5	7
29	R:R:M48	R:R:W57	8.14	No	Yes	5	3	6
30	R:R:L60	R:R:M48	4.24	No	No	5	4	3
31	R:R:K50	R:R:R49	3.71	No	No	0	6	6
32	R:R:K50	R:R:R267	7.43	No	No	0	6	5
33	R:R:I51	R:R:W57	4.7	No	Yes	0	5	6
34	R:R:D53	R:R:S55	8.83	No	No	7	4	4
35	R:R:D53	R:R:Q56	9.14	No	Yes	7	4	5
36	R:R:Q56	R:R:S55	7.22	Yes	No	7	5	4
37	R:R:S55	R:R:W199	6.18	No	Yes	7	4	5
38	R:R:Q56	R:R:W199	7.67	Yes	Yes	7	5	5
39	R:R:L265	R:R:Q56	3.99	No	Yes	0	5	5
40	R:R:L60	R:R:W57	4.56	No	Yes	5	4	6
41	R:R:N58	R:R:S123	7.45	No	No	0	6	5
42	R:R:H110	R:R:V59	5.54	Yes	No	0	8	5
43	R:R:L60	R:R:P61	3.28	No	No	5	4	5
44	R:R:P61	R:R:W126	8.11	No	No	5	5	5
45	R:R:L130	R:R:P61	3.28	No	No	5	4	5
46	R:R:C106	R:R:T62	3.38	No	No	0	8	5
47	R:R:A109	R:R:T62	3.36	No	No	10	7	5
48	R:R:I129	R:R:T62	4.56	No	No	10	5	5
49	R:R:Q63	R:R:Y257	6.76	No	Yes	1	6	8
50	R:R:E261	R:R:Q63	8.92	Yes	No	1	8	6
51	R:R:C103	R:R:F66	4.19	Yes	Yes	1	9	6
52	R:R:C106	R:R:F66	5.59	No	Yes	0	8	6
53	R:R:F66	R:R:L107	7.31	Yes	No	1	6	9
54	R:R:F253	R:R:F66	11.79	Yes	Yes	1	8	6
55	R:R:F66	R:R:I258	3.77	Yes	No	0	6	6
56	R:R:I258	R:R:L67	5.71	No	No	0	6	8
57	R:R:C103	R:R:S69	3.44	Yes	No	0	9	5
58	R:R:F253	R:R:V70	3.93	Yes	No	0	8	8
59	R:R:G72	R:R:L99	5.13	No	No	0	9	8
60	R:R:L73	R:R:L99	4.15	No	No	0	7	8
61	R:R:F100	R:R:L73	7.31	Yes	No	0	9	7
62	R:R:L246	R:R:L73	5.54	Yes	No	0	9	7
63	R:R:A250	R:R:F74	8.32	No	Yes	0	8	9
64	R:R:F74	R:R:W251	13.03	Yes	Yes	9	9	6
65	R:R:F80	R:R:L76	7.31	Yes	No	1	9	8
66	R:R:F96	R:R:L76	3.65	Yes	No	1	9	8
67	R:R:L246	R:R:L76	4.15	Yes	No	1	9	8
68	R:R:A77	R:R:L246	4.73	No	Yes	0	8	9
69	R:R:F80	R:R:R92	16.03	Yes	No	0	9	9
70	R:R:F80	R:R:F96	4.29	Yes	Yes	1	9	9
71	R:R:F170	R:R:F80	3.22	Yes	Yes	1	9	9
72	R:R:D239	R:R:F80	4.78	No	Yes	0	9	9
73	R:R:F80	R:R:V242	5.24	Yes	No	0	9	7
74	R:R:I81	R:R:I82	5.89	No	No	0	9	8
75	R:R:C243	R:R:I81	3.27	No	No	0	8	9
76	R:R:I82	R:R:Q86	5.49	No	No	0	8	4
77	R:R:L84	R:R:R92	6.07	No	No	0	4	9
78	R:R:L84	R:R:Y93	3.52	No	Yes	1	4	8
79	R:R:L166	R:R:L84	4.15	No	No	1	4	4
80	R:R:N85	R:R:Q86	14.52	No	No	0	6	4
81	R:R:Q86	R:R:Q87	3.84	No	No	0	4	4
82	R:R:T88	R:R:V91	3.17	No	No	0	9	7
83	R:R:R92	R:R:T88	7.76	No	No	0	9	9
84	R:R:A89	R:R:F158	4.16	No	Yes	0	8	3
85	R:R:L95	R:R:V91	5.96	No	No	0	9	7
86	R:R:F158	R:R:Y93	5.16	Yes	Yes	1	3	8
87	R:R:L166	R:R:Y93	3.52	No	Yes	1	4	8
88	R:R:D169	R:R:Y93	13.79	No	Yes	0	9	8
89	R:R:F170	R:R:Y93	9.28	Yes	Yes	1	9	8
90	R:R:F94	R:R:V98	3.93	Yes	No	0	8	9
91	R:R:A144	R:R:F94	5.55	No	Yes	0	8	8
92	R:R:L95	R:R:L99	4.15	No	No	0	9	8
93	R:R:F100	R:R:F96	16.08	Yes	Yes	0	9	9
94	R:R:F170	R:R:F96	13.93	Yes	Yes	1	9	9
95	R:R:F96	R:R:L174	7.31	Yes	Yes	1	9	8
96	R:R:F96	R:R:L246	9.74	Yes	Yes	1	9	9
97	R:R:G97	R:R:Q140	4.93	No	Yes	0	9	9
98	R:R:F100	R:R:F104	6.43	Yes	Yes	0	9	9
99	R:R:F100	R:R:W217	7.02	Yes	Yes	0	9	9
100	R:R:F100	R:R:N249	8.46	Yes	Yes	0	9	9
101	R:R:C103	R:R:F104	9.78	Yes	Yes	1	9	9
102	R:R:C103	R:R:F253	5.59	Yes	Yes	1	9	8
103	R:R:F104	R:R:V177	5.24	Yes	No	1	9	9
104	R:R:F104	R:R:M181	13.68	Yes	No	0	9	7
105	R:R:F104	R:R:S213	5.28	Yes	No	0	9	9
106	R:R:F104	R:R:F253	8.57	Yes	Yes	1	9	8
107	R:R:C136	R:R:S105	3.44	No	No	0	6	8
108	R:R:I206	R:R:L107	5.71	Yes	No	1	7	9
109	R:R:L107	R:R:Y257	5.86	No	Yes	1	9	8
110	R:R:L108	R:R:T184	8.84	No	No	0	7	6
111	R:R:A109	R:R:I129	3.25	No	No	10	7	5
112	R:R:H110	R:R:L114	7.71	Yes	No	1	8	8
113	R:R:H110	R:R:H202	7.17	Yes	Yes	1	8	7
114	R:R:H110	R:R:I206	6.63	Yes	Yes	1	8	7
115	R:R:H110	R:R:Y257	9.8	Yes	Yes	1	8	8
116	R:R:E261	R:R:H110	7.39	Yes	Yes	1	8	8
117	R:R:A111	R:R:V187	3.39	No	No	0	5	5
118	R:R:N113	R:R:S123	4.47	No	No	0	6	5
119	R:R:I129	R:R:N113	5.66	No	No	0	5	6
120	R:R:H202	R:R:L114	5.14	Yes	No	1	7	8
121	R:R:K116	R:R:V115	6.07	No	No	0	5	6
122	R:R:R119	R:R:V115	6.54	No	No	0	7	6
123	R:R:F124	R:R:K116	11.17	No	No	0	6	5
124	R:R:L117	R:R:S123	7.51	No	No	0	8	5
125	R:R:L117	R:R:W199	11.39	No	Yes	0	8	5
126	R:R:V118	R:R:W199	3.68	No	Yes	0	5	5
127	R:R:F124	R:R:T128	10.38	No	No	0	6	4
128	R:R:S125	R:R:T127	4.8	No	No	0	6	4
129	R:R:T127	R:R:W126	6.06	No	No	0	4	5
130	R:R:L130	R:R:W126	4.56	No	No	5	4	5
131	R:R:I134	R:R:L130	4.28	Yes	No	0	4	4
132	R:R:C136	R:R:L180	6.35	No	No	0	6	9
133	R:R:L139	R:R:Y176	18.76	No	No	0	9	9
134	R:R:I143	R:R:Q140	5.49	No	Yes	0	9	9
135	R:R:Q140	R:R:Y176	9.02	Yes	No	0	9	9
136	R:R:I143	S:S:E146	8.2	No	No	0	9	8
137	R:R:E146	S:S:I143	6.83	No	No	0	8	9
138	R:R:E146	S:S:E146	27.91	No	No	0	8	8
139	R:R:I151	R:R:Y147	3.63	No	Yes	1	8	8
140	R:R:F158	R:R:Y147	4.13	Yes	Yes	1	3	8
141	R:R:D169	R:R:Y147	9.2	No	Yes	0	9	8
142	R:R:L173	R:R:Y147	3.52	No	Yes	0	8	8
143	R:R:Y147	S:S:L150	14.07	Yes	No	0	8	6
144	R:R:L150	S:S:Y147	11.72	No	Yes	2	6	8
145	R:R:L150	S:S:L150	11.07	No	No	0	6	6
146	R:R:L150	S:S:I151	7.14	No	No	2	6	8
147	R:R:F158	R:R:I151	11.3	Yes	No	1	3	8
148	R:R:R154	S:S:M161	3.72	Yes	No	0	8	3
149	R:R:R154	S:S:Q165	10.51	Yes	No	0	8	6
150	R:R:G155	S:S:M156	3.49	No	No	0	4	3
151	R:R:M156	R:R:N160	8.41	No	No	0	3	1
152	R:R:M156	S:S:M156	10.11	No	No	0	3	3
153	R:R:M157	R:R:V159	6.09	No	No	0	1	2
154	R:R:M161	S:S:R154	4.96	No	Yes	0	3	8
155	R:R:P163	R:R:T162	3.5	No	No	0	6	5
156	R:R:Q165	R:R:T162	9.92	No	No	0	6	5
157	R:R:P163	R:R:P235	5.84	No	No	0	6	4
158	R:R:Q165	S:S:R154	10.51	No	Yes	0	6	8
159	R:R:F170	R:R:N167	3.62	Yes	No	1	9	8
160	R:R:L224	R:R:N167	5.49	No	No	1	8	8
161	R:R:D238	R:R:N167	12.12	No	No	1	8	8
162	R:R:F170	R:R:L174	3.65	Yes	Yes	1	9	8
163	R:R:F170	R:R:W220	4.01	Yes	Yes	0	9	9
164	R:R:I221	R:R:V171	4.61	No	No	0	8	8
165	R:R:L174	R:R:V177	4.47	Yes	No	1	8	9
166	R:R:L174	R:R:W217	5.69	Yes	Yes	1	8	9
167	R:R:V177	R:R:W217	3.68	No	Yes	1	9	9
168	R:R:F179	R:R:L183	8.53	No	No	0	3	5
169	R:R:M181	R:R:W217	11.63	No	Yes	0	7	9
170	R:R:T184	R:R:V210	3.17	No	No	0	6	4
171	R:R:F185	R:R:F186	4.29	No	No	0	4	3
172	R:R:F185	R:R:F207	5.36	No	No	0	4	4
173	R:R:F186	R:R:K189	16.13	No	No	0	3	1
174	R:R:I206	R:R:S188	9.29	Yes	No	0	7	7
175	R:R:F192	R:R:K200	4.96	No	No	0	5	6
176	R:R:F192	R:R:F207	3.22	No	No	0	5	4
177	R:R:G194	R:R:P195	4.06	No	No	0	8	5
178	R:R:E197	R:R:K200	6.75	No	No	0	3	6
179	R:R:N198	R:R:W199	3.39	No	Yes	0	4	5
180	R:R:H202	R:R:Q201	8.65	Yes	No	1	7	4
181	R:R:Q201	R:R:R204	3.5	No	No	0	4	4
182	R:R:I264	R:R:Q201	8.23	No	No	1	3	4
183	R:R:E261	R:R:H202	16	Yes	Yes	1	8	7
184	R:R:H202	R:R:I264	10.61	Yes	No	1	7	3
185	R:R:H202	R:R:L265	6.43	Yes	No	0	7	5
186	R:R:L205	R:R:Y257	4.69	No	Yes	1	4	8
187	R:R:L205	R:R:P260	6.57	No	No	0	4	8
188	R:R:E261	R:R:L205	3.98	Yes	No	1	8	4
189	R:R:I206	R:R:Y257	8.46	Yes	Yes	1	7	8
190	R:R:T209	R:R:Y257	8.74	No	Yes	0	8	8
191	R:R:F212	R:R:V252	3.93	No	No	0	3	7
192	R:R:N249	R:R:S213	5.96	Yes	No	0	9	9
193	R:R:I216	R:R:W217	4.7	No	Yes	0	9	9
194	R:R:I216	R:R:N249	9.91	No	Yes	0	9	9
195	R:R:W217	R:R:W220	14.99	Yes	Yes	0	9	9
196	R:R:V218	R:R:V219	3.21	No	No	0	7	7
197	R:R:I221	R:R:W220	14.09	No	Yes	0	8	9
198	R:R:V242	R:R:W220	6.13	No	Yes	0	7	9
199	R:R:A245	R:R:W220	6.48	No	Yes	0	9	9
200	R:R:M223	R:R:N228	4.21	No	Yes	0	7	8
201	R:R:M223	R:R:V241	4.56	No	No	0	7	8
202	R:R:L224	R:R:N228	4.12	No	Yes	0	8	8
203	R:R:D238	R:R:L224	5.43	No	No	1	8	8
204	R:R:Q230	R:R:R226	14.02	No	No	0	1	4
205	R:R:N228	R:R:R233	4.82	Yes	No	0	8	2
206	R:R:F231	R:R:R233	7.48	No	No	0	1	2
207	R:R:R233	R:R:W237	27.99	No	Yes	0	2	8
208	R:R:P235	R:R:Q234	4.74	No	No	0	4	3
209	R:R:D238	R:R:P235	4.83	No	No	0	8	4
210	R:R:Q236	R:R:W237	8.76	No	Yes	6	1	8
211	R:R:V241	R:R:W237	3.68	No	Yes	0	8	8
212	R:R:D239	R:R:P240	4.83	No	No	0	9	8
213	R:R:F253	R:R:N249	9.67	Yes	Yes	0	8	9
214	R:R:L256	R:R:V252	4.47	No	No	0	3	7
215	R:R:E261	R:R:Y257	8.98	Yes	Yes	1	8	8
216	R:R:P260	R:R:V259	3.53	No	No	0	8	5
217	S:S:G10	S:S:T9	5.46	No	No	0	4	2
218	S:S:G10	S:S:L14	3.42	No	No	0	4	4
219	S:S:F13	S:S:Y12	16.5	No	No	0	3	8
220	S:S:A18	S:S:E19	6.03	No	Yes	0	5	3
221	S:S:E19	S:S:W22	3.27	Yes	Yes	8	3	9
222	S:S:E19	S:S:Q236	8.92	Yes	No	8	3	1
223	S:S:E19	S:S:W237	6.54	Yes	Yes	8	3	8
224	S:S:G20	S:S:P21	4.06	No	No	0	4	4
225	S:S:G20	S:S:W22	9.85	No	Yes	0	4	9
226	S:S:W22	S:S:W237	13.12	Yes	Yes	8	9	8
227	S:S:P240	S:S:W22	10.81	No	Yes	0	8	9
228	S:S:E27	S:S:I24	5.47	No	No	0	9	8
229	S:S:C243	S:S:L26	6.35	No	Yes	0	8	5
230	S:S:I244	S:S:L26	5.71	No	Yes	0	8	5
231	S:S:L29	S:S:W251	3.42	No	Yes	0	4	6
232	S:S:F74	S:S:G33	9.03	Yes	No	11	9	9
233	S:S:G33	S:S:W251	4.22	No	Yes	11	9	6
234	S:S:T37	S:S:V70	3.17	No	No	0	6	8
235	S:S:L71	S:S:T37	5.9	No	No	0	5	6
236	S:S:L254	S:S:T37	7.37	No	No	0	5	6
237	S:S:I38	S:S:L42	4.28	No	No	0	3	4
238	S:S:L40	S:S:L67	4.15	No	No	3	8	8
239	S:S:I258	S:S:L40	4.28	No	No	3	6	8
240	S:S:L41	S:S:L67	4.15	No	No	0	5	8
241	S:S:F44	S:S:Q63	5.86	No	No	0	6	6
242	S:S:F44	S:S:L262	4.87	No	No	0	6	4
243	S:S:K50	S:S:L47	5.64	No	No	0	6	7
244	S:S:I51	S:S:L47	5.71	No	No	0	5	7
245	S:S:M48	S:S:W57	3.49	No	Yes	0	3	6
246	S:S:K50	S:S:R49	3.71	No	No	0	6	6
247	S:S:K50	S:S:R267	7.43	No	No	0	6	5
248	S:S:I51	S:S:W57	7.05	No	Yes	0	5	6
249	S:S:D53	S:S:S55	8.83	No	No	4	4	4
250	S:S:D53	S:S:Q56	9.14	No	Yes	4	4	5
251	S:S:Q56	S:S:S55	7.22	Yes	No	4	5	4
252	S:S:S55	S:S:W199	4.94	No	Yes	4	4	5
253	S:S:Q56	S:S:W199	6.57	Yes	Yes	4	5	5
254	S:S:L265	S:S:Q56	3.99	No	Yes	0	5	5
255	S:S:L60	S:S:W57	4.56	No	Yes	0	4	6
256	S:S:N58	S:S:S123	7.45	No	No	0	6	5
257	S:S:H110	S:S:V59	4.15	Yes	No	0	8	5
258	S:S:L60	S:S:P61	3.28	No	No	0	4	5
259	S:S:P61	S:S:W126	8.11	No	No	0	5	5
260	S:S:C106	S:S:T62	3.38	No	No	0	8	5
261	S:S:A109	S:S:T62	3.36	No	No	4	7	5
262	S:S:I129	S:S:T62	6.08	No	No	4	5	5
263	S:S:E261	S:S:Q63	7.65	Yes	No	0	8	6
264	S:S:C103	S:S:F66	4.19	Yes	Yes	2	9	6
265	S:S:C106	S:S:F66	5.59	No	Yes	0	8	6
266	S:S:F66	S:S:L107	7.31	Yes	No	0	6	9
267	S:S:F253	S:S:F66	11.79	Yes	Yes	2	8	6
268	S:S:I258	S:S:L67	5.71	No	No	3	6	8
269	S:S:C103	S:S:S69	3.44	Yes	No	0	9	5
270	S:S:F253	S:S:V70	3.93	Yes	No	0	8	8
271	S:S:G72	S:S:L99	5.13	No	No	0	9	8
272	S:S:L73	S:S:L99	4.15	No	No	0	7	8
273	S:S:F100	S:S:L73	7.31	Yes	No	0	9	7
274	S:S:L246	S:S:L73	5.54	Yes	No	0	9	7
275	S:S:A250	S:S:F74	8.32	No	Yes	0	8	9
276	S:S:F74	S:S:W251	14.03	Yes	Yes	11	9	6
277	S:S:F80	S:S:L76	7.31	Yes	No	2	9	8
278	S:S:F96	S:S:L76	3.65	Yes	No	2	9	8
279	S:S:L246	S:S:L76	4.15	Yes	No	2	9	8
280	S:S:A77	S:S:L246	4.73	No	Yes	0	8	9
281	S:S:F80	S:S:R92	17.1	Yes	No	0	9	9
282	S:S:F80	S:S:F96	4.29	Yes	Yes	2	9	9
283	S:S:F170	S:S:F80	3.22	Yes	Yes	2	9	9
284	S:S:D239	S:S:F80	4.78	No	Yes	0	9	9
285	S:S:F80	S:S:V242	5.24	Yes	No	0	9	7
286	S:S:I81	S:S:I82	4.42	No	No	0	9	8
287	S:S:C243	S:S:I81	3.27	No	No	0	8	9
288	S:S:I82	S:S:Q86	5.49	No	No	0	8	4
289	S:S:L84	S:S:R92	4.86	No	No	0	4	9
290	S:S:L84	S:S:Y93	5.86	No	Yes	2	4	8
291	S:S:L166	S:S:L84	4.15	No	No	2	4	4
292	S:S:N85	S:S:Q86	14.52	No	No	0	6	4
293	S:S:T88	S:S:V91	3.17	No	No	0	9	7
294	S:S:R92	S:S:T88	7.76	No	No	0	9	9
295	S:S:A89	S:S:F158	4.16	No	Yes	0	8	3
296	S:S:L95	S:S:V91	4.47	No	No	0	9	7
297	S:S:F158	S:S:Y93	9.28	Yes	Yes	2	3	8
298	S:S:L166	S:S:Y93	4.69	No	Yes	2	4	8
299	S:S:D169	S:S:Y93	11.49	No	Yes	0	9	8
300	S:S:F170	S:S:Y93	5.16	Yes	Yes	2	9	8
301	S:S:F94	S:S:L95	6.09	Yes	No	0	8	9
302	S:S:F94	S:S:V98	3.93	Yes	No	0	8	9
303	S:S:A144	S:S:F94	5.55	No	Yes	0	8	8
304	S:S:L95	S:S:L99	6.92	No	No	0	9	8
305	S:S:F100	S:S:F96	15	Yes	Yes	0	9	9
306	S:S:F170	S:S:F96	10.72	Yes	Yes	2	9	9
307	S:S:F96	S:S:L174	7.31	Yes	Yes	2	9	8
308	S:S:F96	S:S:L246	9.74	Yes	Yes	2	9	9
309	S:S:G97	S:S:Q140	4.93	No	Yes	0	9	9
310	S:S:F100	S:S:F104	6.43	Yes	Yes	0	9	9
311	S:S:F100	S:S:W217	9.02	Yes	Yes	0	9	9
312	S:S:F100	S:S:N249	6.04	Yes	Yes	0	9	9
313	S:S:C103	S:S:F104	9.78	Yes	Yes	2	9	9
314	S:S:C103	S:S:F253	5.59	Yes	Yes	2	9	8
315	S:S:F104	S:S:V177	5.24	Yes	No	2	9	9
316	S:S:F104	S:S:M181	13.68	Yes	No	0	9	7
317	S:S:F104	S:S:S213	5.28	Yes	No	2	9	9
318	S:S:F104	S:S:F253	8.57	Yes	Yes	2	9	8
319	S:S:C136	S:S:S105	3.44	No	No	0	6	8
320	S:S:L107	S:S:Y257	5.86	No	Yes	0	9	8
321	S:S:L108	S:S:T184	8.84	No	No	0	7	6
322	S:S:A109	S:S:I129	3.25	No	No	4	7	5
323	S:S:H110	S:S:L114	10.29	Yes	No	3	8	8
324	S:S:H110	S:S:H202	7.17	Yes	Yes	3	8	7
325	S:S:H110	S:S:I206	10.61	Yes	Yes	3	8	7
326	S:S:H110	S:S:Y257	10.89	Yes	Yes	3	8	8
327	S:S:E261	S:S:H110	6.15	Yes	Yes	3	8	8
328	S:S:A111	S:S:V187	3.39	No	No	0	5	5
329	S:S:L117	S:S:N113	4.12	No	No	4	8	6
330	S:S:N113	S:S:S123	4.47	No	No	4	6	5
331	S:S:I129	S:S:N113	5.66	No	No	4	5	6
332	S:S:H202	S:S:L114	5.14	Yes	No	3	7	8
333	S:S:K116	S:S:V115	6.07	No	No	0	5	6
334	S:S:R119	S:S:V115	3.92	No	No	0	7	6
335	S:S:F124	S:S:K116	11.17	No	No	0	6	5
336	S:S:L117	S:S:S123	7.51	No	No	4	8	5
337	S:S:L117	S:S:W199	11.39	No	Yes	4	8	5
338	S:S:F124	S:S:T128	9.08	No	No	0	6	4
339	S:S:S125	S:S:T127	4.8	No	No	0	6	4
340	S:S:T127	S:S:W126	6.06	No	No	0	4	5
341	S:S:L130	S:S:W126	4.56	No	No	0	4	5
342	S:S:I134	S:S:L130	4.28	Yes	No	0	4	4
343	S:S:G135	S:S:L138	3.42	No	No	0	4	5
344	S:S:C136	S:S:L180	6.35	No	No	0	6	9
345	S:S:L139	S:S:Y176	18.76	No	No	0	9	9
346	S:S:I143	S:S:Q140	5.49	No	Yes	0	9	9
347	S:S:Q140	S:S:Y176	9.02	Yes	No	0	9	9
348	S:S:I151	S:S:Y147	3.63	No	Yes	2	8	8
349	S:S:F158	S:S:Y147	4.13	Yes	Yes	2	3	8
350	S:S:D169	S:S:Y147	10.34	No	Yes	0	9	8
351	S:S:L173	S:S:Y147	3.52	No	Yes	0	8	8
352	S:S:F158	S:S:I151	7.54	Yes	No	2	3	8
353	S:S:M156	S:S:N160	11.22	No	No	0	3	1
354	S:S:M157	S:S:V159	4.56	No	No	0	1	2
355	S:S:P163	S:S:T162	3.5	No	No	0	6	5
356	S:S:Q165	S:S:T162	15.59	No	No	0	6	5
357	S:S:P163	S:S:P235	5.84	No	No	0	6	4
358	S:S:F170	S:S:N167	3.62	Yes	No	2	9	8
359	S:S:L224	S:S:N167	5.49	No	No	2	8	8
360	S:S:D238	S:S:N167	10.77	Yes	No	2	8	8
361	S:S:F170	S:S:L174	3.65	Yes	Yes	2	9	8
362	S:S:F170	S:S:W220	4.01	Yes	Yes	0	9	9
363	S:S:I221	S:S:V171	6.14	No	No	0	8	8
364	S:S:L174	S:S:V177	4.47	Yes	No	2	8	9
365	S:S:L174	S:S:W217	5.69	Yes	Yes	2	8	9
366	S:S:V177	S:S:W217	3.68	No	Yes	2	9	9
367	S:S:L178	S:S:W217	3.42	No	Yes	0	7	9
368	S:S:F179	S:S:L183	6.09	No	No	0	3	5
369	S:S:M181	S:S:W217	11.63	No	Yes	0	7	9
370	S:S:T184	S:S:V210	3.17	No	No	0	6	4
371	S:S:F185	S:S:F186	5.36	Yes	No	12	4	3
372	S:S:F185	S:S:F207	5.36	Yes	No	0	4	4
373	S:S:S188	S:S:T191	3.2	No	No	0	7	4
374	S:S:I206	S:S:S188	9.29	Yes	No	0	7	7
375	S:S:G194	S:S:P195	4.06	No	No	0	8	5
376	S:S:E197	S:S:K200	8.1	No	No	0	3	6
377	S:S:N198	S:S:W199	4.52	No	Yes	0	4	5
378	S:S:H202	S:S:Q201	8.65	Yes	No	3	7	4
379	S:S:Q201	S:S:R204	3.5	No	No	0	4	4
380	S:S:I264	S:S:Q201	8.23	No	No	3	3	4
381	S:S:E261	S:S:H202	16	Yes	Yes	3	8	7
382	S:S:H202	S:S:I264	10.61	Yes	No	3	7	3
383	S:S:H202	S:S:L265	5.14	Yes	No	0	7	5
384	S:S:L205	S:S:Y257	3.52	No	Yes	3	4	8
385	S:S:L205	S:S:P260	6.57	No	No	0	4	8
386	S:S:E261	S:S:L205	3.98	Yes	No	3	8	4
387	S:S:I206	S:S:Y257	7.25	Yes	Yes	3	7	8
388	S:S:I208	S:S:L256	8.56	No	No	0	3	3
389	S:S:T209	S:S:Y257	8.74	No	Yes	0	8	8
390	S:S:N249	S:S:S213	5.96	Yes	No	2	9	9
391	S:S:F253	S:S:S213	3.96	Yes	No	2	8	9
392	S:S:A245	S:S:I216	3.25	No	No	0	9	9
393	S:S:I216	S:S:N249	5.66	No	Yes	0	9	9
394	S:S:W217	S:S:W220	14.99	Yes	Yes	0	9	9
395	S:S:V218	S:S:V219	3.21	No	No	0	7	7
396	S:S:I221	S:S:W220	15.27	No	Yes	0	8	9
397	S:S:V242	S:S:W220	6.13	No	Yes	0	7	9
398	S:S:A245	S:S:W220	6.48	No	Yes	0	9	9
399	S:S:L224	S:S:N228	4.12	No	No	0	8	8
400	S:S:D238	S:S:L224	5.43	Yes	No	2	8	8
401	S:S:Q230	S:S:R226	14.02	No	No	0	1	4
402	S:S:N228	S:S:R233	4.82	No	No	0	8	2
403	S:S:F231	S:S:R233	7.48	No	No	0	1	2
404	S:S:R233	S:S:W237	25.99	No	Yes	0	2	8
405	S:S:P235	S:S:Q234	4.74	No	No	2	4	3
406	S:S:D238	S:S:Q234	3.92	Yes	No	2	8	3
407	S:S:D238	S:S:P235	6.44	Yes	No	2	8	4
408	S:S:Q236	S:S:W237	6.57	No	Yes	8	1	8
409	S:S:V241	S:S:W237	3.68	No	Yes	0	8	8
410	S:S:D239	S:S:P240	4.83	No	No	0	9	8
411	S:S:F253	S:S:N249	9.67	Yes	Yes	2	8	9
412	S:S:L254	S:S:W251	3.42	No	Yes	0	5	6
413	S:S:L255	S:S:W251	9.11	No	Yes	0	4	6
414	S:S:L256	S:S:V252	5.96	No	No	0	3	7
415	S:S:I258	S:S:Y257	3.63	No	Yes	3	6	8
416	S:S:E261	S:S:Y257	5.61	Yes	Yes	3	8	8
417	S:S:P260	S:S:V259	3.53	No	No	0	8	5
418	R:R:I81	R:R:S8	3.1	No	No	0	9	6
419	R:R:I31	R:R:S28	3.1	No	No	0	5	6
420	R:R:I134	R:R:S137	3.1	Yes	No	0	4	5
421	S:S:I24	S:S:S28	3.1	No	No	0	8	6
422	S:S:I132	S:S:S112	3.1	No	No	0	4	4
423	S:S:I134	S:S:S137	3.1	Yes	No	0	4	5
424	R:R:I31	R:R:V35	3.07	No	No	0	5	5
425	R:R:I141	R:R:V98	3.07	No	No	0	7	9
426	S:S:I141	S:S:V98	3.07	No	No	0	7	9
427	R:R:I216	R:R:T248	3.04	No	No	0	9	5
428	S:S:K200	S:S:V118	3.04	No	Yes	0	6	5
429	S:S:M223	S:S:V241	3.04	No	No	0	7	8
430	R:R:A101	R:R:Q140	3.03	No	Yes	0	6	9
431	S:S:A101	S:S:Q140	3.03	No	Yes	0	6	9
432	R:R:M152	R:R:T149	3.01	No	No	0	5	7
433	S:S:M152	S:S:T149	3.01	No	No	0	5	7
434	R:R:L102	R:R:S69	3	No	No	0	5	5
435	R:R:L102	R:R:S137	3	No	No	0	5	5
436	R:R:K200	R:R:T191	3	No	No	0	6	4
437	R:R:G227	R:R:R226	3	No	No	0	7	4
438	S:S:L102	S:S:S69	3	No	No	0	5	5
439	S:S:L102	S:S:S137	3	No	No	0	5	5
440	S:S:K200	S:S:T191	3	No	No	0	6	4
441	S:S:G227	S:S:R226	3	No	No	0	7	4
442	R:R:L26	R:R:V247	2.98	Yes	No	0	5	9
443	R:R:L254	R:R:V36	2.98	No	No	0	5	4
444	R:R:L108	R:R:V187	2.98	No	No	0	7	5
445	S:S:L26	S:S:V247	2.98	Yes	No	0	5	9
446	S:S:L254	S:S:V36	2.98	No	No	0	5	4
447	S:S:L108	S:S:V187	2.98	No	No	0	7	5
448	R:R:N249	R:R:V252	2.96	Yes	No	0	9	7
449	S:S:N249	S:S:V252	2.96	Yes	No	0	9	7
450	S:S:L107	S:S:T184	2.95	No	No	0	9	6
451	R:R:D17	R:R:S8	2.94	No	No	0	8	6
452	R:R:I34	R:R:I38	2.94	Yes	No	0	4	3
453	S:S:D17	S:S:S8	2.94	No	No	0	8	6
454	S:S:I34	S:S:I38	2.94	No	No	0	4	3
455	R:R:I34	R:R:L71	2.85	Yes	No	0	4	5
456	R:R:I134	R:R:L65	2.85	Yes	No	0	4	3
457	R:R:I208	R:R:L256	2.85	No	No	0	3	3
458	S:S:I31	S:S:L32	2.85	No	No	0	5	5
459	S:S:I38	S:S:L71	2.85	No	No	0	3	5
460	S:S:I134	S:S:L65	2.85	Yes	No	0	4	3
461	S:S:I134	S:S:L138	2.85	Yes	No	0	4	5
462	S:S:I215	S:S:L211	2.85	No	No	0	5	3
463	S:S:L45	S:S:M48	2.83	No	No	0	5	3
464	R:R:C243	R:R:F80	2.79	No	Yes	0	8	9
465	S:S:C243	S:S:F80	2.79	No	Yes	0	8	9
466	R:R:L65	R:R:L68	2.77	No	No	0	3	4
467	R:R:L108	R:R:L183	2.77	No	No	0	7	5
468	S:S:L41	S:S:L64	2.77	No	No	0	5	5
469	S:S:L65	S:S:L68	2.77	No	No	0	3	4
470	S:S:L108	S:S:L183	2.77	No	No	0	7	5
471	R:R:L173	R:R:Q140	2.66	No	Yes	0	8	9
472	S:S:L173	S:S:Q140	2.66	No	Yes	0	8	9
473	R:R:F124	R:R:S112	2.64	No	No	0	6	4
474	S:S:F124	S:S:S112	2.64	No	No	0	6	4
475	R:R:E83	R:R:N85	2.63	No	No	0	3	6
476	S:S:E83	S:S:N85	2.63	No	No	0	3	6
477	R:R:F74	R:R:V70	2.62	Yes	No	0	9	8
478	R:R:F74	R:R:V247	2.62	Yes	No	0	9	9
479	R:R:F94	R:R:V148	2.62	Yes	No	0	8	7
480	S:S:F94	S:S:V148	2.62	Yes	No	0	8	7
481	S:S:R119	S:S:V118	2.62	No	Yes	0	7	5
482	S:S:F185	S:S:V210	2.62	Yes	No	0	4	4
483	S:S:F212	S:S:V252	2.62	No	No	0	3	7
484	R:R:C54	R:R:W57	2.61	No	Yes	0	4	6
485	S:S:C54	S:S:W57	2.61	No	Yes	0	4	6
486	R:R:F94	R:R:T145	2.59	Yes	No	0	8	6
487	R:R:R154	R:R:T153	2.59	Yes	No	0	8	6
488	S:S:R154	S:S:T153	2.59	Yes	No	0	8	6
489	S:S:Q86	S:S:Q87	2.56	No	No	0	4	4
490	R:R:F158	R:R:M157	2.49	Yes	No	0	3	1
491	R:R:F94	R:R:L95	2.44	Yes	No	0	8	9
492	R:R:F104	R:R:L180	2.44	Yes	No	0	9	9
493	S:S:F104	S:S:L180	2.44	Yes	No	0	9	9
494	S:S:L32	S:S:W251	2.28	No	Yes	0	5	6
495	S:S:F192	S:S:F207	2.14	No	No	0	5	4
496	R:R:G155	S:S:G155	2.11	No	No	0	4	4
497	R:R:G227	R:R:P229	2.03	No	No	0	7	1
498	S:S:G227	S:S:P229	2.03	No	No	0	7	1
499	R:R:A89	R:R:P90	1.87	No	No	0	8	6
500	S:S:A89	S:S:P90	1.87	No	No	0	8	6
501	R:R:G194	R:R:V118	1.84	No	No	0	8	5
502	S:S:G194	S:S:V118	1.84	No	Yes	0	8	5
503	R:R:A133	R:R:C106	1.81	No	No	0	8	8
504	S:S:A133	S:S:C106	1.81	No	No	0	8	8
505	R:R:G75	R:R:I34	1.76	No	Yes	0	5	4
506	S:S:G203	S:S:I206	1.76	No	Yes	0	7	7
507	R:R:A111	R:R:S188	1.71	No	No	0	5	7
508	R:R:G203	R:R:L114	1.71	No	No	0	7	8
509	R:R:C196	R:R:V118	1.71	No	No	0	4	5
510	R:R:G135	R:R:L138	1.71	No	No	0	4	5
511	S:S:C196	S:S:V118	1.71	No	Yes	0	4	5
512	R:R:C164	R:R:T162	1.69	No	No	0	1	5
513	S:S:C164	S:S:T162	1.69	No	No	0	1	5
514	R:R:D17	R:R:G23	1.68	No	No	0	8	9
515	S:S:D11	S:S:G10	1.68	No	No	0	6	4
516	R:R:N228	R:R:P229	1.63	Yes	No	0	8	1
517	S:S:N228	S:S:P229	1.63	No	No	0	8	1
518	R:R:A109	R:R:I132	1.62	No	No	0	7	4
519	R:R:C121	R:R:K116	1.62	No	No	0	5	5
520	R:R:S222	R:R:V219	1.62	No	No	0	4	7
521	R:R:A190	R:R:K189	1.61	No	No	0	4	1
522	R:R:V115	R:R:V187	1.6	No	No	0	6	5
523	R:R:S125	R:R:T128	1.6	No	No	0	6	4
524	R:R:V168	R:R:V172	1.6	No	No	0	2	7
525	R:R:S188	R:R:T191	1.6	No	No	0	7	4
526	S:S:V168	S:S:V172	1.6	No	No	0	2	7
527	R:R:T149	R:R:V148	1.59	No	No	0	7	7
528	S:S:T145	S:S:V148	1.59	No	No	0	6	7
529	S:S:T149	S:S:V148	1.59	No	No	0	7	7
530	R:R:I24	R:R:S28	1.55	No	No	0	8	6
531	S:S:I81	S:S:S8	1.55	No	No	0	9	6
532	R:R:I215	R:R:V218	1.54	No	No	0	5	7
533	S:S:I31	S:S:V35	1.54	No	No	0	5	5
534	S:S:I215	S:S:V218	1.54	No	No	0	5	7
535	S:S:I216	S:S:T248	1.52	No	No	0	9	5
536	R:R:F78	R:R:G75	1.51	No	No	0	9	5
537	S:S:F74	S:S:G75	1.51	Yes	No	0	9	5
538	S:S:F78	S:S:G75	1.51	No	No	0	9	5
539	R:R:G155	R:R:R154	1.5	No	Yes	0	4	8
540	S:S:G155	S:S:R154	1.5	No	Yes	0	4	8
541	R:R:I31	R:R:I34	1.47	No	Yes	0	5	4
542	S:S:M152	S:S:M157	1.44	No	No	0	5	1
543	R:R:I25	R:R:L26	1.43	No	Yes	0	8	5
544	R:R:I134	R:R:L138	1.43	Yes	No	0	4	5
545	R:R:L139	S:S:I142	1.43	No	No	0	9	7
546	R:R:I142	S:S:L139	1.43	No	No	0	7	9
547	R:R:I215	R:R:L211	1.43	No	No	0	5	3
548	S:S:I25	S:S:L26	1.43	No	Yes	0	8	5
549	R:R:L178	R:R:M181	1.41	No	No	0	7	7
550	R:R:A79	R:R:F78	1.39	No	No	0	8	9
551	S:S:A30	S:S:F74	1.39	No	Yes	0	9	9
552	S:S:A79	S:S:F78	1.39	No	No	0	8	9
553	R:R:L14	R:R:L15	1.38	No	No	0	4	8
554	R:R:L39	R:R:L42	1.38	No	No	0	4	4
555	R:R:L41	R:R:L64	1.38	No	No	0	5	5
556	S:S:L14	S:S:L15	1.38	No	No	0	4	8
557	R:R:D11	R:R:L14	1.36	No	No	0	6	4
558	S:S:F185	S:S:K189	1.24	Yes	No	12	4	1
559	S:S:F186	S:S:K189	1.24	No	No	12	3	1
560	S:S:F192	S:S:K189	1.24	No	No	0	5	1
561	R:R:F207	R:R:L211	1.22	No	No	0	4	3
562	S:S:F207	S:S:L211	1.22	No	No	0	4	3
563	R:R:L225	R:R:R226	1.21	No	No	0	5	4
564	S:S:L225	S:S:R226	1.21	No	No	0	5	4
565	R:R:D11	R:R:Y12	1.15	No	No	0	6	8
566	S:S:D11	S:S:Y12	1.15	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:E19	6.19	4	6	3
2	R:R:W22	9.2625	4	6	9
3	R:R:L26	3.72	4	0	5
4	R:R:I34	2.255	4	0	4
5	R:R:Q56	7.005	4	7	5
6	R:R:W57	5.0025	4	5	6
7	R:R:F66	6.53	5	1	6
8	R:R:F74	7.124	5	9	9
9	R:R:F80	6.23714	7	1	9
10	R:R:Y93	7.054	5	1	8
11	R:R:F94	3.426	5	0	8
12	R:R:F96	9.16667	6	1	9
13	R:R:F100	9.06	5	0	9
14	R:R:C103	5.75	4	1	9
15	R:R:F104	7.34571	7	1	9
16	R:R:H110	7.37333	6	1	8
17	R:R:I134	2.915	4	0	4
18	R:R:Q140	5.026	5	0	9
19	R:R:Y147	6.91	5	1	8
20	R:R:R154	4.58	4	0	8
21	R:R:F158	5.448	5	1	3
22	R:R:F170	6.285	6	1	9
23	R:R:L174	5.28	4	1	8
24	R:R:W199	6.462	5	7	5
25	R:R:H202	9	6	1	7
26	R:R:I206	7.5225	4	1	7
27	R:R:W217	7.95167	6	1	9
28	R:R:W220	9.14	5	0	9
29	R:R:N228	3.695	4	0	8
30	R:R:W237	12.018	5	6	8
31	R:R:L246	6.04	4	1	9
32	R:R:N249	7.392	5	0	9
33	R:R:W251	6.875	4	9	6
34	R:R:F253	7.91	5	1	8
35	R:R:Y257	7.61286	7	1	8
36	R:R:E261	9.054	5	1	8
37	S:S:E19	6.19	4	8	3
38	S:S:W22	9.2625	4	8	9
39	S:S:L26	4.1175	4	0	5
40	S:S:Q56	6.73	4	4	5
41	S:S:W57	4.4275	4	0	6
42	S:S:F66	7.22	4	2	6
43	S:S:F74	6.856	5	11	9
44	S:S:F80	6.39	7	2	9
45	S:S:Y93	7.296	5	2	8
46	S:S:F94	4.5475	4	0	8
47	S:S:F96	8.45167	6	2	9
48	S:S:F100	8.76	5	0	9
49	S:S:C103	5.75	4	2	9
50	S:S:F104	7.34571	7	2	9
51	S:S:H110	8.21	6	3	8
52	S:S:V118	2.3025	4	0	5
53	S:S:I134	3.27	4	0	4
54	S:S:Q140	5.026	5	0	9
55	S:S:Y147	6.668	5	2	8
56	S:S:R154	4.89	4	0	8
57	S:S:F158	6.2775	4	2	3
58	S:S:F170	5.06333	6	2	9
59	S:S:L174	5.28	4	2	8
60	S:S:F185	3.645	4	12	4
61	S:S:W199	6.855	4	4	5
62	S:S:H202	8.785	6	3	7
63	S:S:I206	7.2275	4	3	7
64	S:S:W217	8.07167	6	2	9
65	S:S:W220	9.376	5	0	9
66	S:S:W237	11.18	5	8	8
67	S:S:D238	6.64	4	2	8
68	S:S:L246	6.04	4	2	9
69	S:S:N249	6.058	5	2	9
70	S:S:W251	6.08	6	11	6
71	S:S:F253	7.25167	6	2	8
72	S:S:Y257	6.5	7	3	8
73	S:S:E261	7.878	5	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F100	R:R:F96	54.1502	16.08	Yes	Yes	0	9	9
2	R:R:F100	R:R:F104	35.7809	6.43	Yes	Yes	0	9	9
3	R:R:F104	R:R:F253	34.5884	8.57	Yes	Yes	1	9	8
4	R:R:F100	R:R:N249	18.1521	8.46	Yes	Yes	0	9	9
5	R:R:F253	R:R:N249	17.433	9.67	Yes	Yes	0	8	9
6	R:R:C103	R:R:F104	35.3808	9.78	Yes	Yes	1	9	9
7	R:R:C103	R:R:F66	30.4352	4.19	Yes	Yes	1	9	6
8	R:R:F253	R:R:F66	45.8587	11.79	Yes	Yes	1	8	6
9	R:R:F66	R:R:L107	63.1743	7.31	Yes	No	1	6	9
10	R:R:L107	R:R:Y257	31.5847	5.86	No	Yes	1	9	8
11	R:R:I206	R:R:L107	30.9346	5.71	Yes	No	1	7	9
12	R:R:H110	R:R:I206	11.8683	6.63	Yes	Yes	1	8	7
13	R:R:H110	R:R:H202	18.445	7.17	Yes	Yes	1	8	7
14	R:R:H202	R:R:L265	19.7672	6.43	Yes	No	0	7	5
15	R:R:L265	R:R:Q56	17.7914	3.99	No	Yes	0	5	5
16	R:R:H110	R:R:Y257	11.8492	9.8	Yes	Yes	1	8	8
17	R:R:C106	R:R:F66	10.5473	5.59	No	Yes	0	8	6
18	R:R:Q56	R:R:W199	11.864	7.67	Yes	Yes	7	5	5
19	R:R:F170	R:R:Y93	97.9366	9.28	Yes	Yes	1	9	8
20	R:R:F158	R:R:Y93	49.9609	5.16	Yes	Yes	1	3	8
21	R:R:D169	R:R:Y93	49.8276	13.79	No	Yes	0	9	8
22	R:R:F170	R:R:L174	36.2119	3.65	Yes	Yes	1	9	8
23	R:R:F158	R:R:Y147	50.1231	4.13	Yes	Yes	1	3	8
24	R:R:D169	R:R:Y147	49.8653	9.2	No	Yes	0	9	8
25	R:R:L174	R:R:V177	35.4417	4.47	Yes	No	1	8	9
26	R:R:I206	R:R:S188	18.4708	9.29	Yes	No	0	7	7
27	R:R:V118	R:R:W199	10.5379	3.68	No	Yes	0	5	5
28	R:R:Y147	S:S:L150	99.9889	14.07	Yes	No	0	8	6
29	R:R:L150	S:S:L150	100	11.07	No	No	0	6	6
30	R:R:L150	S:S:Y147	66.7628	11.72	No	Yes	2	6	8
31	R:R:L150	S:S:I151	33.2487	7.14	No	No	2	6	8
32	S:S:F158	S:S:Y147	33.4546	4.13	Yes	Yes	2	3	8
33	S:S:F158	S:S:Y93	66.4165	9.28	Yes	Yes	2	3	8
34	S:S:F170	S:S:Y93	97.0783	5.16	Yes	Yes	2	9	8
35	S:S:F158	S:S:I151	33.2171	7.54	Yes	No	2	3	8
36	S:S:D169	S:S:Y147	33.3477	10.34	No	Yes	0	9	8
37	S:S:D169	S:S:Y93	33.3157	11.49	No	Yes	0	9	8
38	S:S:F170	S:S:F96	53.571	10.72	Yes	Yes	2	9	9
39	S:S:F100	S:S:F96	52.8236	15	Yes	Yes	0	9	9
40	S:S:F100	S:S:F104	34.6821	6.43	Yes	Yes	0	9	9
41	S:S:F104	S:S:F253	33.4027	8.57	Yes	Yes	2	9	8
42	S:S:F253	S:S:V70	10.3061	3.93	Yes	No	0	8	8
43	S:S:F170	S:S:L174	35.0696	3.65	Yes	Yes	2	9	8
44	S:S:L174	S:S:V177	34.4339	4.47	Yes	No	2	8	9
45	S:S:F104	S:S:V177	34.3222	5.24	Yes	No	2	9	9
46	S:S:F100	S:S:N249	17.7483	6.04	Yes	Yes	0	9	9
47	S:S:F253	S:S:N249	16.8187	9.67	Yes	Yes	2	8	9
48	S:S:C103	S:S:F104	34.0621	9.78	Yes	Yes	2	9	9
49	S:S:C103	S:S:F66	26.3403	4.19	Yes	Yes	2	9	6
50	S:S:F66	S:S:L107	55.3453	7.31	Yes	No	0	6	9
51	S:S:L107	S:S:Y257	40.7248	5.86	No	Yes	0	9	8
52	S:S:F253	S:S:F66	39.5605	11.79	Yes	Yes	2	8	6
53	S:S:L107	S:S:T184	13.8706	2.95	No	No	0	9	6
54	S:S:I206	S:S:Y257	13.8557	7.25	Yes	Yes	3	7	8
55	S:S:I206	S:S:S188	12.2372	9.29	Yes	No	0	7	7
56	S:S:S188	S:S:T191	11.4219	3.2	No	No	0	7	4
57	S:S:K200	S:S:T191	10.6065	3	No	No	0	6	4
58	R:R:F170	R:R:F96	54.6378	13.93	Yes	Yes	1	9	9
59	R:R:F104	R:R:V177	35.3763	5.24	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8YZK

PDB Summary
PDB	8YZK
Class	C
SubFamily	Orphan
Type	Orphan
SubType	GPRC5D
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.4
Date	2024-07-03
D.O.I.	10.1038/s41467-024-49625-y

Net Summary
I_min	3.17
Number of Linked Nodes	485
Number of Links	566
Number of Hubs	73
Number of Links mediated by Hubs	289
Number of Communities	12
Number of Nodes involved in Communities	110
Number of Links involved in Communities	153

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	3150853
Length Of Smallest Path	3
Average Path Length	27.9772
Length of Longest Path	45
Minimum Path Strength	1.24
Average Path Strength	7.71017
Maximum Path Strength	20.555
Minimum Path Correlation	0.7
Average Path Correlation	0.987194
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	39.221
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	60.391
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • catalytic activity, acting on a protein • molecular function activator activity • kinase activity • protein kinase activity • transferase activity • protein kinase regulator activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • kinase activator activity • enzyme activator activity • molecular function regulator activity • protein kinase activator activity • catalytic activity • kinase regulator activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • protein-containing complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • extracellular exosome • extracellular vesicle • extracellular organelle
Gene Ontology	Biological Process
Gene Ontology	Cellular Component	• protein-containing complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • periplasmic space
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NZD1
Sequence	>8YZK_Chain_R C I E S T G D Y F L L C D A E G P W G I I L E S L A I L G I V V T I L L L L A F L F L M R K I Q D C S Q W N V L P T Q L L F L L S V L G L F G L A F A F I I E L N Q Q T A P V R Y F L F G V L F A L C F S C L L A H A S N L V K L V R G C V S F S W T T I L C I A I G C S L L Q I I I A T E Y V T L I M T R G M M F V N M T P C Q L N V D F V V L L V Y V L F L M A L T F F V S K A T F C G P C E N W K Q H G R L I F I T V L F S I I I W V V W I S M L L R G N P Q F Q R Q P Q W D D P V V C I A L V T N A W V F L L L Y I V P E L C I L Y R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	Q9NZD1
Sequence	>8YZK_Chain_S C I E S T G D Y F L L C D A E G P W G I I L E S L A I L G I V V T I L L L L A F L F L M R K I Q D C S Q W N V L P T Q L L F L L S V L G L F G L A F A F I I E L N Q Q T A P V R Y F L F G V L F A L C F S C L L A H A S N L V K L V R G C V S F S W T T I L C I A I G C S L L Q I I I A T E Y V T L I M T R G M M F V N M T P C Q L N V D F V V L L V Y V L F L M A L T F F V S K A T F C G P C E N W K Q H G R L I F I T V L F S I I I W V V W I S M L L R G N P Q F Q R Q P Q W D D P V V C I A L V T N A W V F L L L Y I V P E L C I L Y R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IMA	C	Orphan	Orphan	GPRC5D	Homo sapiens	Talquetamab	-	-	2.65	2024-09-11	doi.org/10.1016/j.jmb.2024.168748
	8YZK	C	Orphan	Orphan	GPRC5D	Homo sapiens	-	-	-	3.4	2024-07-03	10.1038/s41467-024-49625-y

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8YZK.zip

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