psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V1	R:R:Y177	5.05	No	Yes	0	0	4
2	L:L:V1	R:R:S186	8.08	No	No	0	0	5
3	L:L:S3	R:R:W87	11.12	No	No	1	0	6
4	L:L:S3	R:R:N106	5.96	No	Yes	1	0	6
5	L:L:S3	R:R:F109	5.28	No	No	1	0	6
6	L:L:E4	R:R:D176	5.2	No	No	0	0	6
7	L:L:E4	R:R:Y177	6.73	No	Yes	1	0	4
8	L:L:E4	R:R:Y183	7.86	No	Yes	1	0	3
9	L:L:V5	R:R:Y91	6.31	No	Yes	0	0	5
10	L:L:S6	R:R:Y91	5.09	No	Yes	0	0	5
11	L:L:R9	R:R:P21	4.32	No	No	0	0	4
12	L:L:R9	R:R:E23	9.3	No	No	0	0	3
13	R:R:C22	R:R:C259	5.46	Yes	No	0	9	7
14	R:R:C22	R:R:K262	6.47	Yes	No	0	9	1
15	R:R:A26	R:R:N24	4.69	No	No	0	4	3
16	R:R:E266	R:R:N24	14.46	No	No	0	4	3
17	R:R:A26	R:R:Y267	9.34	No	No	0	4	1
18	R:R:T31	R:R:W27	7.28	No	No	0	5	3
19	R:R:F29	R:R:Y267	5.16	No	No	0	7	1
20	R:R:H92	R:R:T31	6.85	No	No	0	3	5
21	R:R:T34	R:R:Y38	7.49	No	Yes	0	5	7
22	R:R:T34	R:R:Y91	11.24	No	Yes	0	5	5
23	R:R:H92	R:R:T35	6.85	No	No	0	3	5
24	R:R:L37	R:R:V36	4.47	No	No	0	5	6
25	R:R:L37	R:R:N274	5.49	No	No	0	5	5
26	R:R:L84	R:R:Y38	10.55	No	Yes	0	7	7
27	R:R:I88	R:R:Y38	7.25	No	Yes	0	7	7
28	R:R:F277	R:R:Y38	7.22	Yes	Yes	0	7	7
29	R:R:L40	R:R:L44	6.92	No	No	0	5	5
30	R:R:F42	R:R:L43	4.87	No	No	0	6	5
31	R:R:N49	R:R:S45	4.47	Yes	Yes	0	9	8
32	R:R:A81	R:R:S45	3.42	No	Yes	0	6	8
33	R:R:C280	R:R:S45	5.16	Yes	Yes	0	9	8
34	R:R:D77	R:R:N49	4.04	Yes	Yes	0	9	9
35	R:R:L78	R:R:N49	8.24	No	Yes	0	7	9
36	R:R:N49	R:R:P284	4.89	Yes	No	0	9	9
37	R:R:F289	R:R:L51	7.31	Yes	No	2	7	5
38	R:R:L298	R:R:L51	5.54	Yes	No	2	6	5
39	R:R:C74	R:R:V52	3.42	No	No	0	9	8
40	R:R:V288	R:R:V52	11.22	Yes	No	2	7	8
41	R:R:F289	R:R:V52	3.93	Yes	No	2	7	8
42	R:R:K58	R:R:W54	9.28	No	No	0	4	4
43	R:R:V301	R:R:W54	4.9	No	No	0	6	4
44	R:R:K58	R:R:Y59	10.75	No	Yes	0	4	5
45	R:R:H297	R:R:Y59	15.24	Yes	Yes	0	4	5
46	R:R:V301	R:R:Y59	5.05	No	Yes	0	6	5
47	R:R:E60	R:R:N67	7.89	Yes	No	0	6	7
48	R:R:E60	R:R:K293	8.1	Yes	No	3	6	7
49	R:R:E60	R:R:F294	5.83	Yes	No	0	6	9
50	R:R:E60	R:R:H297	11.08	Yes	Yes	3	6	4
51	R:R:E63	R:R:S61	5.75	No	No	0	6	6
52	R:R:F69	R:R:L65	6.09	Yes	No	0	7	6
53	R:R:L65	R:R:R146	4.86	No	Yes	0	6	8
54	R:R:I68	R:R:R146	3.76	No	Yes	0	7	8
55	R:R:F119	R:R:F69	5.36	No	Yes	0	8	7
56	R:R:F69	R:R:I122	7.54	Yes	No	0	7	7
57	R:R:F69	R:R:M123	3.73	Yes	No	0	7	8
58	R:R:I70	R:R:V288	4.61	No	Yes	0	8	7
59	R:R:F119	R:R:N72	12.08	No	No	0	8	9
60	R:R:N72	R:R:W154	11.3	No	Yes	0	9	9
61	R:R:S115	R:R:S76	6.52	No	No	5	7	8
62	R:R:S76	R:R:W154	4.94	No	Yes	5	8	9
63	R:R:D77	R:R:H279	8.82	Yes	Yes	1	9	9
64	R:R:C280	R:R:D77	4.67	Yes	Yes	0	9	9
65	R:R:D77	R:R:N283	6.73	Yes	No	1	9	9
66	R:R:F80	R:R:L84	3.65	Yes	No	0	7	7
67	R:R:F109	R:R:F80	8.57	No	Yes	1	6	7
68	R:R:F80	R:R:S112	5.28	Yes	No	0	7	8
69	R:R:F80	R:R:L113	6.09	Yes	No	1	7	8
70	R:R:F277	R:R:F80	8.57	Yes	Yes	1	7	7
71	R:R:C280	R:R:F80	4.19	Yes	Yes	0	9	7
72	R:R:L105	R:R:L83	5.54	No	No	0	6	7
73	R:R:L105	R:R:V86	4.47	No	No	0	6	6
74	R:R:W87	R:R:W95	7.5	No	Yes	1	6	9
75	R:R:N106	R:R:W87	3.39	Yes	No	1	6	6
76	R:R:P90	R:R:S89	5.34	No	No	0	5	4
77	R:R:S89	R:R:W93	4.94	No	No	0	4	4
78	R:R:P90	R:R:W95	5.4	No	Yes	0	5	9
79	R:R:R273	R:R:Y91	4.12	Yes	Yes	0	6	5
80	R:R:L97	R:R:W95	11.39	Yes	Yes	1	8	9
81	R:R:C102	R:R:W95	7.84	No	Yes	1	9	9
82	R:R:C175	R:R:W95	9.14	No	Yes	1	9	9
83	R:R:L101	R:R:L97	11.07	No	Yes	1	6	8
84	R:R:D99	R:R:K103	9.68	No	No	0	2	7
85	R:R:D99	R:R:V170	5.84	No	No	0	2	5
86	R:R:C102	R:R:V170	3.42	No	No	0	9	5
87	R:R:C102	R:R:C175	5.46	No	No	1	9	9
88	R:R:K103	R:R:K169	4.31	No	No	0	7	4
89	R:R:D164	R:R:N106	9.42	No	Yes	1	4	6
90	R:R:H168	R:R:N106	11.48	No	Yes	1	5	6
91	R:R:M107	R:R:T165	4.52	No	No	0	6	4
92	R:R:F109	R:R:F277	6.43	No	Yes	1	6	7
93	R:R:S110	R:R:Y114	5.09	No	Yes	0	4	7
94	R:R:S110	R:R:S161	4.89	No	No	0	4	7
95	R:R:I111	R:R:S157	7.74	Yes	No	0	6	7
96	R:R:I111	R:R:I158	5.89	Yes	No	0	6	4
97	R:R:I111	R:R:S161	7.74	Yes	No	0	6	7
98	R:R:H190	R:R:L113	5.14	Yes	No	1	6	8
99	R:R:L113	R:R:W238	4.56	No	Yes	1	8	9
100	R:R:S160	R:R:Y114	6.36	No	Yes	0	5	7
101	R:R:Q189	R:R:Y114	5.64	No	Yes	1	5	7
102	R:R:H190	R:R:Y114	4.36	Yes	Yes	1	6	7
103	R:R:F193	R:R:Y114	6.19	No	Yes	1	7	7
104	R:R:S115	R:R:W154	9.88	No	Yes	5	7	9
105	R:R:H279	R:R:S116	5.58	Yes	No	0	9	9
106	R:R:I117	R:R:W238	5.87	No	Yes	0	8	9
107	R:R:F118	R:R:F193	10.72	No	No	0	5	7
108	R:R:F119	R:R:V153	14.42	No	No	0	8	6
109	R:R:L120	R:R:Y234	4.69	No	Yes	0	8	9
110	R:R:L120	R:R:Y287	11.72	No	Yes	0	8	9
111	R:R:M123	R:R:Y287	4.79	No	Yes	0	8	9
112	R:R:I201	R:R:T124	6.08	No	No	0	8	9
113	R:R:C204	R:R:T124	3.38	No	No	0	8	9
114	R:R:T124	R:R:Y205	4.99	No	Yes	0	9	9
115	R:R:I125	R:R:I200	5.89	No	No	0	6	7
116	R:R:R127	R:R:Y205	7.2	No	Yes	0	9	9
117	R:R:R127	R:R:Y287	4.12	No	Yes	0	9	9
118	R:R:V132	R:R:Y128	7.57	No	Yes	0	8	8
119	R:R:F203	R:R:Y128	6.19	No	Yes	6	5	8
120	R:R:C204	R:R:Y128	9.41	No	Yes	0	8	8
121	R:R:E207	R:R:Y128	4.49	No	Yes	6	4	8
122	R:R:S130	R:R:T137	4.8	No	No	0	8	6
123	R:R:I208	R:R:V131	13.83	No	No	0	8	8
124	R:R:S133	R:R:S136	6.52	No	No	0	6	4
125	R:R:P141	R:R:V140	3.53	No	No	4	6	4
126	R:R:R146	R:R:V140	3.92	Yes	No	4	8	4
127	R:R:P141	R:R:R146	4.32	No	Yes	4	6	8
128	R:R:C145	R:R:T142	3.38	No	No	0	3	7
129	R:R:L143	R:R:R146	10.93	No	Yes	0	1	8
130	R:R:S157	R:R:W154	3.71	No	Yes	0	7	9
131	R:R:F167	R:R:L163	9.74	No	No	0	5	7
132	R:R:D164	R:R:H168	7.56	No	No	1	4	5
133	R:R:D164	R:R:Y177	10.34	No	Yes	1	4	4
134	R:R:F167	R:R:I166	8.79	No	No	0	5	4
135	R:R:F167	R:R:W182	31.07	No	No	0	5	3
136	R:R:H168	R:R:Y177	9.8	No	Yes	1	5	4
137	R:R:K169	R:R:S178	6.12	No	No	0	4	5
138	R:R:Y177	R:R:Y183	6.95	Yes	Yes	1	4	3
139	R:R:E179	R:R:S178	4.31	No	No	0	4	5
140	R:R:E179	R:R:W182	10.9	No	No	0	4	3
141	R:R:L180	R:R:Y183	3.52	No	Yes	1	1	3
142	R:R:L180	R:R:L184	5.54	No	No	1	1	3
143	R:R:L180	R:R:R252	3.64	No	No	1	1	3
144	R:R:T181	R:R:W182	7.28	No	No	0	1	3
145	R:R:V187	R:R:Y183	5.05	No	Yes	0	4	3
146	R:R:Q248	R:R:Y183	7.89	No	Yes	0	5	3
147	R:R:T249	R:R:Y183	3.75	No	Yes	1	4	3
148	R:R:R252	R:R:Y183	21.61	No	Yes	1	3	3
149	R:R:L184	R:R:Y188	5.86	No	No	1	3	4
150	R:R:L184	R:R:T249	4.42	No	No	1	3	4
151	R:R:T249	R:R:Y188	6.24	No	No	1	4	4
152	R:R:F193	R:R:Q189	9.37	No	No	1	7	5
153	R:R:H190	R:R:W238	5.29	Yes	Yes	1	6	9
154	R:R:H190	R:R:N242	8.93	Yes	Yes	0	6	8
155	R:R:N191	R:R:N242	8.17	No	Yes	0	4	8
156	R:R:F246	R:R:N191	4.83	No	No	0	6	4
157	R:R:F194	R:R:G239	4.52	Yes	No	0	8	6
158	R:R:F194	R:R:N242	6.04	Yes	Yes	0	8	8
159	R:R:S197	R:R:Y234	7.63	No	Yes	0	9	9
160	R:R:I201	R:R:Y234	7.25	No	Yes	0	8	9
161	R:R:E207	R:R:F203	5.83	No	No	6	4	5
162	R:R:I227	R:R:Y205	7.25	No	Yes	0	7	9
163	R:R:I230	R:R:Y205	6.04	No	Yes	0	8	9
164	R:R:V231	R:R:Y205	3.79	No	Yes	0	8	9
165	R:R:E207	R:R:R210	12.79	No	No	0	4	3
166	R:R:I227	R:R:L209	5.71	No	No	0	7	5
167	R:R:L212	R:R:R220	6.07	No	No	0	8	7
168	R:R:R220	R:R:S217	9.22	No	No	0	7	3
169	R:R:R219	R:R:R222	12.79	No	No	0	4	7
170	R:R:K225	R:R:R222	6.19	No	No	0	6	7
171	R:R:L226	R:R:V290	4.47	No	No	0	8	6
172	R:R:I230	R:R:Y287	3.63	No	Yes	0	8	9
173	R:R:W238	R:R:Y234	3.86	Yes	Yes	0	9	9
174	R:R:S237	R:R:W238	3.71	No	Yes	0	8	9
175	R:R:H279	R:R:W238	8.46	Yes	Yes	1	9	9
176	R:R:G239	R:R:P240	4.06	No	No	0	6	9
177	R:R:N242	R:R:Y241	3.49	Yes	No	0	8	6
178	R:R:L245	R:R:Y241	11.72	No	No	0	5	6
179	R:R:A276	R:R:Y241	6.67	No	No	0	8	6
180	R:R:F243	R:R:L247	3.65	No	No	0	6	4
181	R:R:L269	R:R:T244	5.9	No	No	0	4	5
182	R:R:C272	R:R:T244	5.07	No	No	0	6	5
183	R:R:F246	R:R:L250	4.87	No	No	0	6	4
184	R:R:I255	R:R:L250	7.14	No	No	0	3	4
185	R:R:F251	R:R:I256	10.05	Yes	No	0	2	1
186	R:R:F251	R:R:K262	6.2	Yes	No	0	2	1
187	R:R:F251	R:R:L265	4.87	Yes	No	0	2	5
188	R:R:I255	R:R:I256	7.36	No	No	0	3	1
189	R:R:A261	R:R:S258	3.42	No	No	0	2	7
190	R:R:E260	R:R:Q263	5.1	No	No	0	1	4
191	R:R:L269	R:R:R273	4.86	No	Yes	0	4	6
192	R:R:F277	R:R:R273	5.34	Yes	Yes	0	7	6
193	R:R:F282	R:R:S278	6.61	No	No	0	7	5
194	R:R:H279	R:R:N283	7.65	Yes	No	1	9	9
195	R:R:C281	R:R:F282	4.19	No	No	0	8	7
196	R:R:N283	R:R:Y287	3.49	No	Yes	0	9	9
197	R:R:F289	R:R:V288	9.18	Yes	Yes	2	7	7
198	R:R:F294	R:R:V288	3.93	No	Yes	0	9	7
199	R:R:F289	R:R:L298	13.4	Yes	Yes	2	7	6
200	R:R:H297	R:R:K293	3.93	Yes	No	3	4	7
201	R:R:A268	R:R:T244	3.36	No	No	0	5	5
202	R:R:H300	R:R:Y59	3.27	No	Yes	0	4	5
203	R:R:S112	R:R:V79	3.23	No	No	0	8	6
204	R:R:S197	R:R:T121	3.2	No	No	0	9	7
205	R:R:R222	R:R:R295	3.2	No	No	0	7	8
206	R:R:C39	R:R:L43	3.17	No	No	0	5	5
207	R:R:H92	R:R:W93	3.17	No	No	0	3	4
208	R:R:A30	R:R:L270	3.15	No	No	0	4	4
209	R:R:A33	R:R:L270	3.15	No	No	0	5	4
210	R:R:C74	R:R:N49	3.15	No	Yes	0	9	9
211	R:R:C22	R:R:Q263	3.05	Yes	No	0	9	4
212	R:R:I200	R:R:T121	3.04	No	No	0	7	7
213	R:R:I227	R:R:T223	3.04	No	No	0	7	8
214	R:R:I255	R:R:T253	3.04	No	No	0	3	1
215	R:R:L46	R:R:S50	3	No	No	0	6	4
216	R:R:L73	R:R:S116	3	No	No	0	9	9
217	L:L:S6	R:R:N24	2.98	No	No	0	0	3
218	R:R:L298	R:R:V55	2.98	Yes	No	0	6	7
219	R:R:L202	R:R:V231	2.98	No	No	0	4	8
220	R:R:L209	R:R:V224	2.98	No	No	0	5	6
221	R:R:L212	R:R:T223	2.95	No	No	0	8	8
222	R:R:D176	R:R:S173	2.94	No	No	0	6	5
223	R:R:N72	R:R:T150	2.92	No	No	0	9	7
224	R:R:I111	R:R:M107	2.92	Yes	No	0	6	6
225	R:R:I70	R:R:L56	2.85	No	No	0	8	6
226	R:R:I68	R:R:L62	2.85	No	No	0	7	7
227	R:R:I108	R:R:L83	2.85	No	No	0	5	7
228	R:R:I125	R:R:L129	2.85	No	No	0	6	6
229	R:R:K225	R:R:L226	2.82	No	No	0	6	8
230	R:R:L56	R:R:L71	2.77	No	No	0	6	6
231	R:R:L62	R:R:L71	2.77	No	No	0	7	6
232	R:R:L105	R:R:L97	2.77	No	Yes	0	6	8
233	R:R:A261	R:R:F251	2.77	No	Yes	0	2	2
234	R:R:L270	R:R:N274	2.75	No	No	0	4	5
235	R:R:H126	R:R:T66	2.74	No	No	0	8	7
236	R:R:F69	R:R:V149	2.62	Yes	No	0	7	6
237	R:R:R295	R:R:V292	2.62	No	No	0	8	5
238	R:R:H126	R:R:L65	2.57	No	No	0	8	6
239	R:R:V96	R:R:W93	2.45	No	No	0	3	4
240	R:R:F194	R:R:L198	2.44	Yes	No	0	8	6
241	R:R:I208	R:R:Y128	2.42	No	Yes	0	8	8
242	R:R:L286	R:R:Y287	2.34	No	Yes	0	8	9
243	R:R:N274	R:R:Y38	2.33	No	Yes	0	5	7
244	R:R:G94	R:R:P90	2.03	No	No	0	4	5
245	L:L:C11	R:R:P21	1.88	No	No	0	0	4
246	R:R:G48	R:R:V47	1.84	No	No	0	8	5
247	R:R:G291	R:R:V290	1.84	No	No	0	8	6
248	R:R:P134	R:R:S133	1.78	No	No	0	8	6
249	R:R:C281	R:R:S45	1.72	No	Yes	0	8	8
250	R:R:C280	R:R:V41	1.71	Yes	No	0	9	7
251	R:R:G98	R:R:L97	1.71	No	Yes	1	8	8
252	R:R:G98	R:R:L101	1.71	No	No	1	8	6
253	R:R:G199	R:R:L198	1.71	No	No	0	4	6
254	L:L:T10	R:R:C22	1.69	No	Yes	0	0	9
255	R:R:I88	R:R:P85	1.69	No	No	0	7	8
256	R:R:S133	R:R:V132	1.62	No	No	0	6	8
257	R:R:S136	R:R:T137	1.6	No	No	0	4	6
258	R:R:C281	R:R:L44	1.59	No	No	0	8	5
259	R:R:C74	R:R:L53	1.59	No	No	0	9	6
260	R:R:T211	R:R:V131	1.59	No	No	0	5	8
261	R:R:T211	R:R:V132	1.59	No	No	0	5	8
262	R:R:T296	R:R:V292	1.59	No	No	0	4	5
263	R:R:A233	R:R:L286	1.58	No	No	0	7	8
264	R:R:T181	R:R:T185	1.57	No	No	0	1	5
265	L:L:G2	R:R:R273	1.5	No	Yes	0	0	6
266	R:R:N67	R:R:S64	1.49	No	No	0	7	7
267	R:R:L143	R:R:V147	1.49	No	No	0	1	4
268	R:R:L159	R:R:V155	1.49	No	No	0	4	4
269	R:R:L236	R:R:V232	1.49	No	No	0	5	4
270	L:L:D7	R:R:S173	1.47	No	No	0	0	5
271	R:R:F42	R:R:P85	1.44	No	No	0	6	8
272	R:R:I108	R:R:L104	1.43	No	No	0	5	5
273	R:R:I158	R:R:L159	1.43	No	No	0	4	4
274	R:R:G174	R:R:W95	1.41	No	Yes	0	4	9
275	R:R:K169	R:R:L171	1.41	No	No	0	4	2
276	R:R:L46	R:R:L78	1.38	No	No	0	6	7
277	R:R:L53	R:R:L75	1.38	No	No	0	6	5
278	R:R:L247	R:R:L265	1.38	No	No	0	4	5
279	R:R:L298	R:R:L302	1.38	Yes	No	0	6	7
280	R:R:H297	R:R:T296	1.37	Yes	No	0	4	4
281	R:R:R210	R:R:V206	1.31	No	No	0	3	3
282	R:R:H221	R:R:K225	1.31	No	No	0	5	6
283	R:R:F228	R:R:V232	1.31	No	No	0	4	4
284	R:R:R144	R:R:T142	1.29	No	No	0	5	7
285	L:L:K8	L:L:R9	1.24	No	No	0	0	0
286	R:R:V28	R:R:W27	1.23	No	No	0	4	3
287	R:R:F194	R:R:L195	1.22	Yes	No	0	8	4
288	R:R:F235	R:R:L198	1.22	No	No	0	5	6
289	R:R:F235	R:R:L236	1.22	No	No	0	5	5
290	R:R:L148	R:R:R144	1.21	No	No	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C22	4.1675	4	0	9
2	R:R:Y38	6.968	5	0	7
3	R:R:S45	3.6925	4	0	8
4	R:R:N49	4.958	5	0	9
5	R:R:Y59	8.5775	4	0	5
6	R:R:E60	8.225	4	3	6
7	R:R:F69	5.068	5	0	7
8	R:R:D77	6.065	4	1	9
9	R:R:F80	6.05833	6	1	7
10	R:R:Y91	6.69	4	0	5
11	R:R:W95	7.11333	6	1	9
12	R:R:L97	6.735	4	1	8
13	R:R:N106	7.5625	4	1	6
14	R:R:I111	6.0725	4	0	6
15	R:R:Y114	5.528	5	1	7
16	R:R:Y128	6.016	5	6	8
17	R:R:R146	5.558	5	4	8
18	R:R:W154	7.4575	4	5	9
19	R:R:Y177	7.774	5	1	4
20	R:R:Y183	8.09	7	1	3
21	R:R:H190	5.93	4	1	6
22	R:R:F194	3.555	4	0	8
23	R:R:Y205	5.854	5	0	9
24	R:R:Y234	5.8575	4	0	9
25	R:R:W238	5.29167	6	1	9
26	R:R:N242	6.6575	4	0	8
27	R:R:F251	5.9725	4	0	2
28	R:R:R273	3.955	4	0	6
29	R:R:F277	6.89	4	1	7
30	R:R:H279	7.6275	4	1	9
31	R:R:C280	3.9325	4	0	9
32	R:R:Y287	5.015	6	0	9
33	R:R:V288	7.235	4	2	7
34	R:R:F289	8.455	4	2	7
35	R:R:H297	7.905	4	3	4
36	R:R:L298	5.825	4	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S3	R:R:N106	48.2239	5.96	No	Yes	1	0	6
2	R:R:D164	R:R:N106	26.7452	9.42	No	Yes	1	4	6
3	R:R:D164	R:R:Y177	25.2183	10.34	No	Yes	1	4	4
4	R:R:H168	R:R:N106	26.7452	11.48	No	Yes	1	5	6
5	R:R:H168	R:R:Y177	25.2183	9.8	No	Yes	1	5	4
6	L:L:S3	R:R:F109	100	5.28	No	No	1	0	6
7	L:L:E4	R:R:Y177	12.7029	6.73	No	Yes	1	0	4
8	R:R:Y177	R:R:Y183	28.2186	6.95	Yes	Yes	1	4	3
9	R:R:F109	R:R:F277	10.9081	6.43	No	Yes	1	6	7
10	R:R:F277	R:R:R273	23.2681	5.34	Yes	Yes	0	7	6
11	R:R:R273	R:R:Y91	13.2387	4.12	Yes	Yes	0	6	5
12	L:L:S6	R:R:Y91	10.5706	5.09	No	Yes	0	0	5
13	R:R:F109	R:R:F80	90.1045	8.57	No	Yes	1	6	7
14	R:R:F80	R:R:L113	61.3448	6.09	Yes	No	1	7	8
15	R:R:H190	R:R:L113	34.1388	5.14	Yes	No	1	6	8
16	R:R:H190	R:R:N242	46.4934	8.93	Yes	Yes	0	6	8
17	R:R:N191	R:R:N242	27.4417	8.17	No	Yes	0	4	8
18	R:R:F246	R:R:N191	25.9952	4.83	No	No	0	6	4
19	R:R:F246	R:R:L250	24.5433	4.87	No	No	0	6	4
20	R:R:I255	R:R:L250	23.0806	7.14	No	No	0	3	4
21	R:R:I255	R:R:I256	20.1232	7.36	No	No	0	3	1
22	R:R:F251	R:R:I256	18.6284	10.05	Yes	No	0	2	1
23	R:R:W87	R:R:W95	56.2497	7.5	No	Yes	1	6	9
24	R:R:P90	R:R:W95	17.4069	5.4	No	Yes	0	5	9
25	R:R:P90	R:R:S89	14.0102	5.34	No	No	0	5	4
26	R:R:S89	R:R:W93	12.2957	4.94	No	No	0	4	4
27	R:R:F277	R:R:Y38	21.8002	7.22	Yes	Yes	0	7	7
28	R:R:N274	R:R:Y38	18.0605	2.33	No	Yes	0	5	7
29	R:R:F80	R:R:L84	17.8998	3.65	Yes	No	0	7	7
30	R:R:I88	R:R:Y38	15.0763	7.25	No	Yes	0	7	7
31	R:R:C280	R:R:F80	90.4795	4.19	Yes	Yes	0	9	7
32	R:R:C280	R:R:S45	37.6105	5.16	Yes	Yes	0	9	8
33	R:R:C281	R:R:S45	12.21	1.72	No	Yes	0	8	8
34	R:R:I88	R:R:P85	12.0814	1.69	No	No	0	7	8
35	R:R:N49	R:R:S45	31.91	4.47	Yes	Yes	0	9	8
36	R:R:C280	R:R:D77	61.1144	4.67	Yes	Yes	0	9	9
37	R:R:D77	R:R:N49	61.5698	4.04	Yes	Yes	0	9	9
38	R:R:C74	R:R:N49	75.3978	3.15	No	Yes	0	9	9
39	R:R:C74	R:R:V52	69.5901	3.42	No	No	0	9	8
40	R:R:F289	R:R:V52	10.5545	3.93	Yes	No	2	7	8
41	R:R:V288	R:R:V52	57.0265	11.22	Yes	No	2	7	8
42	R:R:F294	R:R:V288	51.0528	3.93	No	Yes	0	9	7
43	R:R:E60	R:R:F294	48.8133	5.83	Yes	No	0	6	9
44	R:R:E60	R:R:H297	39.9196	11.08	Yes	Yes	3	6	4
45	R:R:H297	R:R:Y59	14.5352	15.24	Yes	Yes	0	4	5
46	R:R:D77	R:R:N283	49.0972	6.73	Yes	No	1	9	9
47	R:R:N283	R:R:Y287	54.1227	3.49	No	Yes	0	9	9
48	R:R:M123	R:R:Y287	31.9314	4.79	No	Yes	0	8	9
49	R:R:F69	R:R:M123	30.4741	3.73	Yes	No	0	7	8
50	R:R:F69	R:R:L65	18.7142	6.09	Yes	No	0	7	6
51	R:R:L65	R:R:R146	14.3209	4.86	No	Yes	0	6	8
52	R:R:F119	R:R:F69	11.6046	5.36	No	Yes	0	8	7
53	R:R:I70	R:R:V288	10.5759	4.61	No	Yes	0	8	7
54	R:R:H190	R:R:Y114	22.0627	4.36	Yes	Yes	1	6	7
55	R:R:S110	R:R:Y114	14.9638	5.09	No	Yes	0	4	7
56	R:R:S110	R:R:S161	13.7262	4.89	No	No	0	4	7
57	R:R:I111	R:R:S161	12.5047	7.74	Yes	No	0	6	7
58	R:R:L113	R:R:W238	27.0506	4.56	No	Yes	1	8	9
59	R:R:H279	R:R:W238	26.3166	8.46	Yes	Yes	1	9	9
60	R:R:D77	R:R:H279	20.9858	8.82	Yes	Yes	1	9	9
61	R:R:L97	R:R:W95	14.0102	11.39	Yes	Yes	1	8	9
62	R:R:C102	R:R:W95	23.9968	7.84	No	Yes	1	9	9
63	R:R:C102	R:R:V170	22.4216	3.42	No	No	0	9	5
64	R:R:D99	R:R:V170	20.7608	5.84	No	No	0	2	5
65	R:R:D99	R:R:K103	19.0892	9.68	No	No	0	2	7
66	R:R:K103	R:R:K169	17.4069	4.31	No	No	0	7	4
67	R:R:W238	R:R:Y234	43.6378	3.86	Yes	Yes	0	9	9
68	R:R:I201	R:R:Y234	31.4117	7.25	No	Yes	0	8	9
69	R:R:I201	R:R:T124	30.1902	6.08	No	No	0	8	9
70	R:R:C204	R:R:T124	34.0209	3.38	No	No	0	8	9
71	R:R:T124	R:R:Y205	24.5808	4.99	No	Yes	0	9	9
72	R:R:R127	R:R:Y287	19.5446	4.12	No	Yes	0	9	9
73	R:R:R127	R:R:Y205	18.1623	7.2	No	Yes	0	9	9
74	R:R:I230	R:R:Y287	19.7911	3.63	No	Yes	0	8	9
75	R:R:I230	R:R:Y205	18.4034	6.04	No	Yes	0	8	9
76	R:R:C204	R:R:Y128	31.8136	9.41	No	Yes	0	8	8
77	R:R:V132	R:R:Y128	16.0139	7.57	No	Yes	0	8	8
78	R:R:S133	R:R:V132	11.6743	1.62	No	No	0	6	8
79	R:R:K169	R:R:S178	14.0102	6.12	No	No	0	4	5
80	R:R:E179	R:R:S178	12.2957	4.31	No	No	0	4	5
81	R:R:E179	R:R:W182	10.5706	10.9	No	No	0	4	3
82	R:R:F194	R:R:N242	15.746	6.04	Yes	Yes	0	8	8
83	R:R:I227	R:R:Y205	22.7485	7.25	No	Yes	0	7	9
84	R:R:I227	R:R:T223	13.0405	3.04	No	No	0	7	8
85	R:R:H297	R:R:T296	23.8146	1.37	Yes	No	0	4	4
86	R:R:T296	R:R:V292	21.4573	1.59	No	No	0	4	5
87	R:R:R295	R:R:V292	19.0892	2.62	No	No	0	8	5
88	R:R:R222	R:R:R295	16.7051	3.2	No	No	0	7	8
89	R:R:K225	R:R:R222	12.1511	6.19	No	No	0	6	7
90	L:L:S3	R:R:W87	50.9135	11.12	No	No	1	0	6
91	R:R:F277	R:R:F80	34.8192	8.57	Yes	Yes	1	7	7
92	R:R:L84	R:R:Y38	16.3729	10.55	No	Yes	0	7	7
93	R:R:H190	R:R:W238	28.9794	5.29	Yes	Yes	1	6	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V1	R:R:Y177	5.05	0	No	Yes	0	4	0	1
L:L:V1	R:R:S186	8.08	0	No	No	0	5	0	1
L:L:S3	R:R:W87	11.12	1	No	No	0	6	0	1
L:L:S3	R:R:N106	5.96	1	No	Yes	0	6	0	1
L:L:S3	R:R:F109	5.28	1	No	No	0	6	0	1
L:L:E4	R:R:D176	5.2	1	No	No	0	6	0	1
L:L:E4	R:R:Y177	6.73	1	No	Yes	0	4	0	1
L:L:E4	R:R:Y183	7.86	1	No	Yes	0	3	0	1
L:L:V5	R:R:Y91	6.31	0	No	Yes	0	5	0	1
L:L:S6	R:R:Y91	5.09	0	No	Yes	0	5	0	1
L:L:R9	R:R:P21	4.32	0	No	No	0	4	0	1
L:L:R9	R:R:E23	9.3	0	No	No	0	3	0	1
R:R:C22	R:R:C259	5.46	0	Yes	No	9	7	1	2
R:R:C22	R:R:K262	6.47	0	Yes	No	9	1	1	2
R:R:A26	R:R:N24	4.69	0	No	No	4	3	2	1
R:R:E266	R:R:N24	14.46	0	No	No	4	3	2	1
R:R:T34	R:R:Y91	11.24	0	No	Yes	5	5	2	1
R:R:F109	R:R:F80	8.57	1	No	Yes	6	7	1	2
R:R:F277	R:R:F80	8.57	1	Yes	Yes	7	7	2	2
R:R:W87	R:R:W95	7.5	1	No	Yes	6	9	1	2
R:R:N106	R:R:W87	3.39	1	Yes	No	6	6	1	1
R:R:R273	R:R:Y91	4.12	0	Yes	Yes	6	5	1	1
R:R:D164	R:R:N106	9.42	1	No	Yes	4	6	2	1
R:R:H168	R:R:N106	11.48	1	No	Yes	5	6	2	1
R:R:F109	R:R:F277	6.43	1	No	Yes	6	7	1	2
R:R:D164	R:R:H168	7.56	1	No	No	4	5	2	2
R:R:D164	R:R:Y177	10.34	1	No	Yes	4	4	2	1
R:R:H168	R:R:Y177	9.8	1	No	Yes	5	4	2	1
R:R:Y177	R:R:Y183	6.95	1	Yes	Yes	4	3	1	1
R:R:L180	R:R:Y183	3.52	1	No	Yes	1	3	2	1
R:R:L180	R:R:R252	3.64	1	No	No	1	3	2	2
R:R:V187	R:R:Y183	5.05	0	No	Yes	4	3	2	1
R:R:Q248	R:R:Y183	7.89	0	No	Yes	5	3	2	1
R:R:T249	R:R:Y183	3.75	1	No	Yes	4	3	2	1
R:R:R252	R:R:Y183	21.61	1	No	Yes	3	3	2	1
R:R:L269	R:R:R273	4.86	0	No	Yes	4	6	2	1
R:R:F277	R:R:R273	5.34	1	Yes	Yes	7	6	2	1
R:R:C22	R:R:Q263	3.05	0	Yes	No	9	4	1	2
L:L:S6	R:R:N24	2.98	0	No	No	0	3	0	1
R:R:D176	R:R:S173	2.94	0	No	No	6	5	1	1
L:L:C11	R:R:P21	1.88	0	No	No	0	4	0	1
L:L:T10	R:R:C22	1.69	0	No	Yes	0	9	0	1
L:L:G2	R:R:R273	1.5	0	No	Yes	0	6	0	1
L:L:D7	R:R:S173	1.47	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9AST_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.38
Number of Linked Nodes	265
Number of Links	290
Number of Hubs	36
Number of Links mediated by Hubs	141
Number of Communities	6
Number of Nodes involved in Communities	48
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	50279
Length Of Smallest Path	3
Average Path Length	13.3478
Length of Longest Path	32
Minimum Path Strength	1.22
Average Path Strength	5.86
Maximum Path Strength	20.985
Minimum Path Correlation	0.7
Average Path Correlation	0.923552
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	45.6442
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.6415
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Lymphotactin
UniProt	P47992
Sequence	>9AST_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P46094
Sequence	>9AST_nogp_Chain_R P C E N Q A W V F A T L A T T V L Y C L V F L L S L V G N S L V L W V L V K Y E S L E S L T N I F I L N L C L S D L V F A C L L P V W I S P Y H W G W V L G D F L C K L L N M I F S I S L Y S S I F F L T I M T I H R Y L S V V S P L S T L R V P T L R C R V L V T M A V W V A S I L S S I L D T I F H K V L S S G C D Y S E L T W Y L T S V Y Q H N L F F L L S L G I I L F C Y V E I L R T L F R S R S K R R H R T V K L I F A I V V A Y F L S W G P Y N F T L F L Q T L F R T Q I I R S C E A K Q Q L E Y A L L I C R N L A F S H C C F N P V L Y V F V G V K F R T H L K H V L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IC0	A	Protein	Chemokine	CXCR1	Homo sapiens	CXCL8	-	Gi1/β1/γ2	3.41	2023-07-19	doi.org/10.1038/s41467-023-39799-2
	8IC0 (No Gprot)	A	Protein	Chemokine	CXCR1	Homo sapiens	CXCL8	-		3.41	2023-07-19	doi.org/10.1038/s41467-023-39799-2
	9AST	A	Protein	Chemokine	XCR1	Homo sapiens	Lymphotactin	-	Gi1/β1/γ2	3.07	2024-12-11	doi.org/10.1073/pnas.2405732121
	9AST (No Gprot)	A	Protein	Chemokine	XCR1	Homo sapiens	Lymphotactin	-		3.07	2024-12-11	doi.org/10.1073/pnas.2405732121

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Download 9AST_nogp.zip

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