psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V1	R:R:Y177	5.05	No	Yes	0	0	4
2	L:L:V1	R:R:S186	8.08	No	No	0	0	5
3	L:L:S3	R:R:W87	11.12	No	No	1	0	6
4	L:L:S3	R:R:N106	5.96	No	Yes	1	0	6
5	L:L:S3	R:R:F109	5.28	No	No	1	0	6
6	L:L:E4	R:R:D176	5.2	No	No	0	0	6
7	L:L:E4	R:R:Y177	6.73	No	Yes	1	0	4
8	L:L:E4	R:R:Y183	7.86	No	Yes	1	0	3
9	L:L:V5	R:R:Y91	6.31	No	Yes	0	0	5
10	L:L:S6	R:R:Y91	5.09	No	Yes	0	0	5
11	L:L:R9	R:R:P21	4.32	No	No	0	0	4
12	L:L:R9	R:R:E23	9.3	No	No	0	0	3
13	R:R:C22	R:R:C259	5.46	Yes	No	0	9	7
14	R:R:C22	R:R:K262	6.47	Yes	No	0	9	1
15	R:R:A26	R:R:N24	4.69	No	No	0	4	3
16	R:R:E266	R:R:N24	14.46	No	No	0	4	3
17	R:R:A26	R:R:Y267	9.34	No	No	0	4	1
18	R:R:T31	R:R:W27	7.28	No	No	0	5	3
19	R:R:F29	R:R:Y267	5.16	No	No	0	7	1
20	R:R:H92	R:R:T31	6.85	No	No	0	3	5
21	R:R:T34	R:R:Y38	7.49	No	Yes	0	5	7
22	R:R:T34	R:R:Y91	11.24	No	Yes	0	5	5
23	R:R:H92	R:R:T35	6.85	No	No	0	3	5
24	R:R:L37	R:R:V36	4.47	No	No	0	5	6
25	R:R:L37	R:R:N274	5.49	No	No	0	5	5
26	R:R:L84	R:R:Y38	10.55	No	Yes	0	7	7
27	R:R:I88	R:R:Y38	7.25	No	Yes	0	7	7
28	R:R:F277	R:R:Y38	7.22	Yes	Yes	0	7	7
29	R:R:L40	R:R:L44	6.92	No	No	0	5	5
30	R:R:F42	R:R:L43	4.87	No	No	0	6	5
31	R:R:N49	R:R:S45	4.47	Yes	Yes	0	9	8
32	R:R:A81	R:R:S45	3.42	No	Yes	0	6	8
33	R:R:C280	R:R:S45	5.16	Yes	Yes	0	9	8
34	R:R:D77	R:R:N49	4.04	Yes	Yes	0	9	9
35	R:R:L78	R:R:N49	8.24	No	Yes	0	7	9
36	R:R:N49	R:R:P284	4.89	Yes	No	0	9	9
37	R:R:F289	R:R:L51	7.31	Yes	No	2	7	5
38	R:R:L298	R:R:L51	5.54	Yes	No	2	6	5
39	R:R:C74	R:R:V52	3.42	No	No	0	9	8
40	R:R:V288	R:R:V52	11.22	Yes	No	2	7	8
41	R:R:F289	R:R:V52	3.93	Yes	No	2	7	8
42	R:R:K58	R:R:W54	9.28	No	No	0	4	4
43	R:R:V301	R:R:W54	4.9	No	No	0	6	4
44	R:R:K58	R:R:Y59	10.75	No	Yes	0	4	5
45	R:R:H297	R:R:Y59	15.24	Yes	Yes	0	4	5
46	R:R:V301	R:R:Y59	5.05	No	Yes	0	6	5
47	R:R:E60	R:R:N67	7.89	Yes	No	0	6	7
48	R:R:E60	R:R:K293	8.1	Yes	No	3	6	7
49	R:R:E60	R:R:F294	5.83	Yes	No	0	6	9
50	R:R:E60	R:R:H297	11.08	Yes	Yes	3	6	4
51	R:R:E63	R:R:S61	5.75	No	No	0	6	6
52	R:R:F69	R:R:L65	6.09	Yes	No	0	7	6
53	R:R:L65	R:R:R146	4.86	No	Yes	0	6	8
54	R:R:I68	R:R:R146	3.76	No	Yes	0	7	8
55	R:R:F119	R:R:F69	5.36	No	Yes	0	8	7
56	R:R:F69	R:R:I122	7.54	Yes	No	0	7	7
57	R:R:F69	R:R:M123	3.73	Yes	No	0	7	8
58	R:R:I70	R:R:V288	4.61	No	Yes	0	8	7
59	R:R:F119	R:R:N72	12.08	No	No	0	8	9
60	R:R:N72	R:R:W154	11.3	No	Yes	0	9	9
61	R:R:S115	R:R:S76	6.52	No	No	5	7	8
62	R:R:S76	R:R:W154	4.94	No	Yes	5	8	9
63	R:R:D77	R:R:H279	8.82	Yes	Yes	1	9	9
64	R:R:C280	R:R:D77	4.67	Yes	Yes	0	9	9
65	R:R:D77	R:R:N283	6.73	Yes	No	1	9	9
66	R:R:F80	R:R:L84	3.65	Yes	No	0	7	7
67	R:R:F109	R:R:F80	8.57	No	Yes	1	6	7
68	R:R:F80	R:R:S112	5.28	Yes	No	0	7	8
69	R:R:F80	R:R:L113	6.09	Yes	No	1	7	8
70	R:R:F277	R:R:F80	8.57	Yes	Yes	1	7	7
71	R:R:C280	R:R:F80	4.19	Yes	Yes	0	9	7
72	R:R:L105	R:R:L83	5.54	No	No	0	6	7
73	R:R:L105	R:R:V86	4.47	No	No	0	6	6
74	R:R:W87	R:R:W95	7.5	No	Yes	1	6	9
75	R:R:N106	R:R:W87	3.39	Yes	No	1	6	6
76	R:R:P90	R:R:S89	5.34	No	No	0	5	4
77	R:R:S89	R:R:W93	4.94	No	No	0	4	4
78	R:R:P90	R:R:W95	5.4	No	Yes	0	5	9
79	R:R:R273	R:R:Y91	4.12	Yes	Yes	0	6	5
80	R:R:L97	R:R:W95	11.39	Yes	Yes	1	8	9
81	R:R:C102	R:R:W95	7.84	No	Yes	1	9	9
82	R:R:C175	R:R:W95	9.14	No	Yes	1	9	9
83	R:R:L101	R:R:L97	11.07	No	Yes	1	6	8
84	R:R:D99	R:R:K103	9.68	No	No	0	2	7
85	R:R:D99	R:R:V170	5.84	No	No	0	2	5
86	R:R:C102	R:R:V170	3.42	No	No	0	9	5
87	R:R:C102	R:R:C175	5.46	No	No	1	9	9
88	R:R:K103	R:R:K169	4.31	No	No	0	7	4
89	R:R:D164	R:R:N106	9.42	No	Yes	1	4	6
90	R:R:H168	R:R:N106	11.48	No	Yes	1	5	6
91	R:R:M107	R:R:T165	4.52	No	No	0	6	4
92	R:R:F109	R:R:F277	6.43	No	Yes	1	6	7
93	R:R:S110	R:R:Y114	5.09	No	Yes	0	4	7
94	R:R:S110	R:R:S161	4.89	No	No	0	4	7
95	R:R:I111	R:R:S157	7.74	Yes	No	0	6	7
96	R:R:I111	R:R:I158	5.89	Yes	No	0	6	4
97	R:R:I111	R:R:S161	7.74	Yes	No	0	6	7
98	R:R:H190	R:R:L113	5.14	Yes	No	1	6	8
99	R:R:L113	R:R:W238	4.56	No	Yes	1	8	9
100	R:R:S160	R:R:Y114	6.36	No	Yes	0	5	7
101	R:R:Q189	R:R:Y114	5.64	No	Yes	1	5	7
102	R:R:H190	R:R:Y114	4.36	Yes	Yes	1	6	7
103	R:R:F193	R:R:Y114	6.19	No	Yes	1	7	7
104	R:R:S115	R:R:W154	9.88	No	Yes	5	7	9
105	R:R:H279	R:R:S116	5.58	Yes	No	0	9	9
106	R:R:I117	R:R:W238	5.87	No	Yes	0	8	9
107	R:R:F118	R:R:F193	10.72	No	No	0	5	7
108	R:R:F119	R:R:V153	14.42	No	No	0	8	6
109	R:R:L120	R:R:Y234	4.69	No	Yes	0	8	9
110	R:R:L120	R:R:Y287	11.72	No	Yes	0	8	9
111	R:R:M123	R:R:Y287	4.79	No	Yes	0	8	9
112	R:R:I201	R:R:T124	6.08	No	No	0	8	9
113	R:R:C204	R:R:T124	3.38	No	No	0	8	9
114	R:R:T124	R:R:Y205	4.99	No	Yes	0	9	9
115	R:R:I125	R:R:I200	5.89	No	No	0	6	7
116	R:R:R127	R:R:Y205	7.2	No	Yes	0	9	9
117	R:R:R127	R:R:Y287	4.12	No	Yes	0	9	9
118	R:R:V132	R:R:Y128	7.57	No	Yes	0	8	8
119	R:R:F203	R:R:Y128	6.19	No	Yes	6	5	8
120	R:R:C204	R:R:Y128	9.41	No	Yes	0	8	8
121	R:R:E207	R:R:Y128	4.49	No	Yes	6	4	8
122	R:R:S130	R:R:T137	4.8	No	No	0	8	6
123	R:R:I208	R:R:V131	13.83	No	No	0	8	8
124	R:R:S133	R:R:S136	6.52	No	No	0	6	4
125	R:R:P141	R:R:V140	3.53	No	No	4	6	4
126	R:R:R146	R:R:V140	3.92	Yes	No	4	8	4
127	R:R:P141	R:R:R146	4.32	No	Yes	4	6	8
128	R:R:C145	R:R:T142	3.38	No	No	0	3	7
129	R:R:L143	R:R:R146	10.93	No	Yes	0	1	8
130	R:R:S157	R:R:W154	3.71	No	Yes	0	7	9
131	R:R:F167	R:R:L163	9.74	No	No	0	5	7
132	R:R:D164	R:R:H168	7.56	No	No	1	4	5
133	R:R:D164	R:R:Y177	10.34	No	Yes	1	4	4
134	R:R:F167	R:R:I166	8.79	No	No	0	5	4
135	R:R:F167	R:R:W182	31.07	No	No	0	5	3
136	R:R:H168	R:R:Y177	9.8	No	Yes	1	5	4
137	R:R:K169	R:R:S178	6.12	No	No	0	4	5
138	R:R:Y177	R:R:Y183	6.95	Yes	Yes	1	4	3
139	R:R:E179	R:R:S178	4.31	No	No	0	4	5
140	R:R:E179	R:R:W182	10.9	No	No	0	4	3
141	R:R:L180	R:R:Y183	3.52	No	Yes	1	1	3
142	R:R:L180	R:R:L184	5.54	No	No	1	1	3
143	R:R:L180	R:R:R252	3.64	No	No	1	1	3
144	R:R:T181	R:R:W182	7.28	No	No	0	1	3
145	R:R:V187	R:R:Y183	5.05	No	Yes	0	4	3
146	R:R:Q248	R:R:Y183	7.89	No	Yes	0	5	3
147	R:R:T249	R:R:Y183	3.75	No	Yes	1	4	3
148	R:R:R252	R:R:Y183	21.61	No	Yes	1	3	3
149	R:R:L184	R:R:Y188	5.86	No	No	1	3	4
150	R:R:L184	R:R:T249	4.42	No	No	1	3	4
151	R:R:T249	R:R:Y188	6.24	No	No	1	4	4
152	R:R:F193	R:R:Q189	9.37	No	No	1	7	5
153	R:R:H190	R:R:W238	5.29	Yes	Yes	1	6	9
154	R:R:H190	R:R:N242	8.93	Yes	Yes	0	6	8
155	R:R:N191	R:R:N242	8.17	No	Yes	0	4	8
156	R:R:F246	R:R:N191	4.83	No	No	0	6	4
157	R:R:F194	R:R:G239	4.52	Yes	No	0	8	6
158	R:R:F194	R:R:N242	6.04	Yes	Yes	0	8	8
159	R:R:S197	R:R:Y234	7.63	No	Yes	0	9	9
160	R:R:I201	R:R:Y234	7.25	No	Yes	0	8	9
161	R:R:E207	R:R:F203	5.83	No	No	6	4	5
162	R:R:I227	R:R:Y205	7.25	No	Yes	0	7	9
163	R:R:I230	R:R:Y205	6.04	No	Yes	0	8	9
164	R:R:V231	R:R:Y205	3.79	No	Yes	0	8	9
165	R:R:E207	R:R:R210	12.79	No	No	0	4	3
166	R:R:I227	R:R:L209	5.71	No	No	0	7	5
167	R:R:L212	R:R:R220	6.07	No	No	0	8	7
168	R:R:R220	R:R:S217	9.22	No	No	0	7	3
169	R:R:R219	R:R:R222	12.79	No	No	0	4	7
170	R:R:K225	R:R:R222	6.19	No	No	0	6	7
171	R:R:L226	R:R:V290	4.47	No	No	0	8	6
172	R:R:I230	R:R:Y287	3.63	No	Yes	0	8	9
173	R:R:W238	R:R:Y234	3.86	Yes	Yes	0	9	9
174	R:R:S237	R:R:W238	3.71	No	Yes	0	8	9
175	R:R:H279	R:R:W238	8.46	Yes	Yes	1	9	9
176	R:R:G239	R:R:P240	4.06	No	No	0	6	9
177	R:R:N242	R:R:Y241	3.49	Yes	No	0	8	6
178	R:R:L245	R:R:Y241	11.72	No	No	0	5	6
179	R:R:A276	R:R:Y241	6.67	No	No	0	8	6
180	R:R:F243	R:R:L247	3.65	No	No	0	6	4
181	R:R:L269	R:R:T244	5.9	No	No	0	4	5
182	R:R:C272	R:R:T244	5.07	No	No	0	6	5
183	R:R:F246	R:R:L250	4.87	No	No	0	6	4
184	R:R:I255	R:R:L250	7.14	No	No	0	3	4
185	R:R:F251	R:R:I256	10.05	Yes	No	0	2	1
186	R:R:F251	R:R:K262	6.2	Yes	No	0	2	1
187	R:R:F251	R:R:L265	4.87	Yes	No	0	2	5
188	R:R:I255	R:R:I256	7.36	No	No	0	3	1
189	R:R:A261	R:R:S258	3.42	No	No	0	2	7
190	R:R:E260	R:R:Q263	5.1	No	No	0	1	4
191	R:R:L269	R:R:R273	4.86	No	Yes	0	4	6
192	R:R:F277	R:R:R273	5.34	Yes	Yes	0	7	6
193	R:R:F282	R:R:S278	6.61	No	No	0	7	5
194	R:R:H279	R:R:N283	7.65	Yes	No	1	9	9
195	R:R:C281	R:R:F282	4.19	No	No	0	8	7
196	R:R:N283	R:R:Y287	3.49	No	Yes	0	9	9
197	R:R:F289	R:R:V288	9.18	Yes	Yes	2	7	7
198	R:R:F294	R:R:V288	3.93	No	Yes	0	9	7
199	R:R:F289	R:R:L298	13.4	Yes	Yes	2	7	6
200	R:R:H297	R:R:K293	3.93	Yes	No	3	4	7
201	R:R:A268	R:R:T244	3.36	No	No	0	5	5
202	R:R:H300	R:R:Y59	3.27	No	Yes	0	4	5
203	R:R:S112	R:R:V79	3.23	No	No	0	8	6
204	R:R:S197	R:R:T121	3.2	No	No	0	9	7
205	R:R:R222	R:R:R295	3.2	No	No	0	7	8
206	R:R:C39	R:R:L43	3.17	No	No	0	5	5
207	R:R:H92	R:R:W93	3.17	No	No	0	3	4
208	R:R:A30	R:R:L270	3.15	No	No	0	4	4
209	R:R:A33	R:R:L270	3.15	No	No	0	5	4
210	R:R:C74	R:R:N49	3.15	No	Yes	0	9	9
211	R:R:C22	R:R:Q263	3.05	Yes	No	0	9	4
212	R:R:I200	R:R:T121	3.04	No	No	0	7	7
213	R:R:I227	R:R:T223	3.04	No	No	0	7	8
214	R:R:I255	R:R:T253	3.04	No	No	0	3	1
215	R:R:L46	R:R:S50	3	No	No	0	6	4
216	R:R:L73	R:R:S116	3	No	No	0	9	9
217	L:L:S6	R:R:N24	2.98	No	No	0	0	3
218	R:R:L298	R:R:V55	2.98	Yes	No	0	6	7
219	R:R:L202	R:R:V231	2.98	No	No	0	4	8
220	R:R:L209	R:R:V224	2.98	No	No	0	5	6
221	R:R:L212	R:R:T223	2.95	No	No	0	8	8
222	R:R:D176	R:R:S173	2.94	No	No	0	6	5
223	R:R:N72	R:R:T150	2.92	No	No	0	9	7
224	R:R:I111	R:R:M107	2.92	Yes	No	0	6	6
225	R:R:I70	R:R:L56	2.85	No	No	0	8	6
226	R:R:I68	R:R:L62	2.85	No	No	0	7	7
227	R:R:I108	R:R:L83	2.85	No	No	0	5	7
228	R:R:I125	R:R:L129	2.85	No	No	0	6	6
229	R:R:K225	R:R:L226	2.82	No	No	0	6	8
230	R:R:L56	R:R:L71	2.77	No	No	0	6	6
231	R:R:L62	R:R:L71	2.77	No	No	0	7	6
232	R:R:L105	R:R:L97	2.77	No	Yes	0	6	8
233	R:R:A261	R:R:F251	2.77	No	Yes	0	2	2
234	R:R:L270	R:R:N274	2.75	No	No	0	4	5
235	R:R:H126	R:R:T66	2.74	No	No	0	8	7
236	R:R:F69	R:R:V149	2.62	Yes	No	0	7	6
237	R:R:R295	R:R:V292	2.62	No	No	0	8	5
238	R:R:H126	R:R:L65	2.57	No	No	0	8	6
239	R:R:V96	R:R:W93	2.45	No	No	0	3	4
240	R:R:F194	R:R:L198	2.44	Yes	No	0	8	6
241	R:R:I208	R:R:Y128	2.42	No	Yes	0	8	8
242	R:R:L286	R:R:Y287	2.34	No	Yes	0	8	9
243	R:R:N274	R:R:Y38	2.33	No	Yes	0	5	7
244	R:R:G94	R:R:P90	2.03	No	No	0	4	5
245	L:L:C11	R:R:P21	1.88	No	No	0	0	4
246	R:R:G48	R:R:V47	1.84	No	No	0	8	5
247	R:R:G291	R:R:V290	1.84	No	No	0	8	6
248	R:R:P134	R:R:S133	1.78	No	No	0	8	6
249	R:R:C281	R:R:S45	1.72	No	Yes	0	8	8
250	R:R:C280	R:R:V41	1.71	Yes	No	0	9	7
251	R:R:G98	R:R:L97	1.71	No	Yes	1	8	8
252	R:R:G98	R:R:L101	1.71	No	No	1	8	6
253	R:R:G199	R:R:L198	1.71	No	No	0	4	6
254	L:L:T10	R:R:C22	1.69	No	Yes	0	0	9
255	R:R:I88	R:R:P85	1.69	No	No	0	7	8
256	R:R:S133	R:R:V132	1.62	No	No	0	6	8
257	R:R:S136	R:R:T137	1.6	No	No	0	4	6
258	R:R:C281	R:R:L44	1.59	No	No	0	8	5
259	R:R:C74	R:R:L53	1.59	No	No	0	9	6
260	R:R:T211	R:R:V131	1.59	No	No	0	5	8
261	R:R:T211	R:R:V132	1.59	No	No	0	5	8
262	R:R:T296	R:R:V292	1.59	No	No	0	4	5
263	R:R:A233	R:R:L286	1.58	No	No	0	7	8
264	R:R:T181	R:R:T185	1.57	No	No	0	1	5
265	L:L:G2	R:R:R273	1.5	No	Yes	0	0	6
266	R:R:N67	R:R:S64	1.49	No	No	0	7	7
267	R:R:L143	R:R:V147	1.49	No	No	0	1	4
268	R:R:L159	R:R:V155	1.49	No	No	0	4	4
269	R:R:L236	R:R:V232	1.49	No	No	0	5	4
270	L:L:D7	R:R:S173	1.47	No	No	0	0	5
271	R:R:F42	R:R:P85	1.44	No	No	0	6	8
272	R:R:I108	R:R:L104	1.43	No	No	0	5	5
273	R:R:I158	R:R:L159	1.43	No	No	0	4	4
274	R:R:G174	R:R:W95	1.41	No	Yes	0	4	9
275	R:R:K169	R:R:L171	1.41	No	No	0	4	2
276	R:R:L46	R:R:L78	1.38	No	No	0	6	7
277	R:R:L53	R:R:L75	1.38	No	No	0	6	5
278	R:R:L247	R:R:L265	1.38	No	No	0	4	5
279	R:R:L298	R:R:L302	1.38	Yes	No	0	6	7
280	R:R:H297	R:R:T296	1.37	Yes	No	0	4	4
281	R:R:R210	R:R:V206	1.31	No	No	0	3	3
282	R:R:H221	R:R:K225	1.31	No	No	0	5	6
283	R:R:F228	R:R:V232	1.31	No	No	0	4	4
284	R:R:R144	R:R:T142	1.29	No	No	0	5	7
285	L:L:K8	L:L:R9	1.24	No	No	0	0	0
286	R:R:V28	R:R:W27	1.23	No	No	0	4	3
287	R:R:F194	R:R:L195	1.22	Yes	No	0	8	4
288	R:R:F235	R:R:L198	1.22	No	No	0	5	6
289	R:R:F235	R:R:L236	1.22	No	No	0	5	5
290	R:R:L148	R:R:R144	1.21	No	No	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C22	4.1675	4	0	9
2	R:R:Y38	6.968	5	0	7
3	R:R:S45	3.6925	4	0	8
4	R:R:N49	4.958	5	0	9
5	R:R:Y59	8.5775	4	0	5
6	R:R:E60	8.225	4	3	6
7	R:R:F69	5.068	5	0	7
8	R:R:D77	6.065	4	1	9
9	R:R:F80	6.05833	6	1	7
10	R:R:Y91	6.69	4	0	5
11	R:R:W95	7.11333	6	1	9
12	R:R:L97	6.735	4	1	8
13	R:R:N106	7.5625	4	1	6
14	R:R:I111	6.0725	4	0	6
15	R:R:Y114	5.528	5	1	7
16	R:R:Y128	6.016	5	6	8
17	R:R:R146	5.558	5	4	8
18	R:R:W154	7.4575	4	5	9
19	R:R:Y177	7.774	5	1	4
20	R:R:Y183	8.09	7	1	3
21	R:R:H190	5.93	4	1	6
22	R:R:F194	3.555	4	0	8
23	R:R:Y205	5.854	5	0	9
24	R:R:Y234	5.8575	4	0	9
25	R:R:W238	5.29167	6	1	9
26	R:R:N242	6.6575	4	0	8
27	R:R:F251	5.9725	4	0	2
28	R:R:R273	3.955	4	0	6
29	R:R:F277	6.89	4	1	7
30	R:R:H279	7.6275	4	1	9
31	R:R:C280	3.9325	4	0	9
32	R:R:Y287	5.015	6	0	9
33	R:R:V288	7.235	4	2	7
34	R:R:F289	8.455	4	2	7
35	R:R:H297	7.905	4	3	4
36	R:R:L298	5.825	4	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S3	R:R:N106	48.2239	5.96	No	Yes	1	0	6
2	R:R:D164	R:R:N106	26.7452	9.42	No	Yes	1	4	6
3	R:R:D164	R:R:Y177	25.2183	10.34	No	Yes	1	4	4
4	R:R:H168	R:R:N106	26.7452	11.48	No	Yes	1	5	6
5	R:R:H168	R:R:Y177	25.2183	9.8	No	Yes	1	5	4
6	L:L:S3	R:R:F109	100	5.28	No	No	1	0	6
7	L:L:E4	R:R:Y177	12.7029	6.73	No	Yes	1	0	4
8	R:R:Y177	R:R:Y183	28.2186	6.95	Yes	Yes	1	4	3
9	R:R:F109	R:R:F277	10.9081	6.43	No	Yes	1	6	7
10	R:R:F277	R:R:R273	23.2681	5.34	Yes	Yes	0	7	6
11	R:R:R273	R:R:Y91	13.2387	4.12	Yes	Yes	0	6	5
12	L:L:S6	R:R:Y91	10.5706	5.09	No	Yes	0	0	5
13	R:R:F109	R:R:F80	90.1045	8.57	No	Yes	1	6	7
14	R:R:F80	R:R:L113	61.3448	6.09	Yes	No	1	7	8
15	R:R:H190	R:R:L113	34.1388	5.14	Yes	No	1	6	8
16	R:R:H190	R:R:N242	46.4934	8.93	Yes	Yes	0	6	8
17	R:R:N191	R:R:N242	27.4417	8.17	No	Yes	0	4	8
18	R:R:F246	R:R:N191	25.9952	4.83	No	No	0	6	4
19	R:R:F246	R:R:L250	24.5433	4.87	No	No	0	6	4
20	R:R:I255	R:R:L250	23.0806	7.14	No	No	0	3	4
21	R:R:I255	R:R:I256	20.1232	7.36	No	No	0	3	1
22	R:R:F251	R:R:I256	18.6284	10.05	Yes	No	0	2	1
23	R:R:W87	R:R:W95	56.2497	7.5	No	Yes	1	6	9
24	R:R:P90	R:R:W95	17.4069	5.4	No	Yes	0	5	9
25	R:R:P90	R:R:S89	14.0102	5.34	No	No	0	5	4
26	R:R:S89	R:R:W93	12.2957	4.94	No	No	0	4	4
27	R:R:F277	R:R:Y38	21.8002	7.22	Yes	Yes	0	7	7
28	R:R:N274	R:R:Y38	18.0605	2.33	No	Yes	0	5	7
29	R:R:F80	R:R:L84	17.8998	3.65	Yes	No	0	7	7
30	R:R:I88	R:R:Y38	15.0763	7.25	No	Yes	0	7	7
31	R:R:C280	R:R:F80	90.4795	4.19	Yes	Yes	0	9	7
32	R:R:C280	R:R:S45	37.6105	5.16	Yes	Yes	0	9	8
33	R:R:C281	R:R:S45	12.21	1.72	No	Yes	0	8	8
34	R:R:I88	R:R:P85	12.0814	1.69	No	No	0	7	8
35	R:R:N49	R:R:S45	31.91	4.47	Yes	Yes	0	9	8
36	R:R:C280	R:R:D77	61.1144	4.67	Yes	Yes	0	9	9
37	R:R:D77	R:R:N49	61.5698	4.04	Yes	Yes	0	9	9
38	R:R:C74	R:R:N49	75.3978	3.15	No	Yes	0	9	9
39	R:R:C74	R:R:V52	69.5901	3.42	No	No	0	9	8
40	R:R:F289	R:R:V52	10.5545	3.93	Yes	No	2	7	8
41	R:R:V288	R:R:V52	57.0265	11.22	Yes	No	2	7	8
42	R:R:F294	R:R:V288	51.0528	3.93	No	Yes	0	9	7
43	R:R:E60	R:R:F294	48.8133	5.83	Yes	No	0	6	9
44	R:R:E60	R:R:H297	39.9196	11.08	Yes	Yes	3	6	4
45	R:R:H297	R:R:Y59	14.5352	15.24	Yes	Yes	0	4	5
46	R:R:D77	R:R:N283	49.0972	6.73	Yes	No	1	9	9
47	R:R:N283	R:R:Y287	54.1227	3.49	No	Yes	0	9	9
48	R:R:M123	R:R:Y287	31.9314	4.79	No	Yes	0	8	9
49	R:R:F69	R:R:M123	30.4741	3.73	Yes	No	0	7	8
50	R:R:F69	R:R:L65	18.7142	6.09	Yes	No	0	7	6
51	R:R:L65	R:R:R146	14.3209	4.86	No	Yes	0	6	8
52	R:R:F119	R:R:F69	11.6046	5.36	No	Yes	0	8	7
53	R:R:I70	R:R:V288	10.5759	4.61	No	Yes	0	8	7
54	R:R:H190	R:R:Y114	22.0627	4.36	Yes	Yes	1	6	7
55	R:R:S110	R:R:Y114	14.9638	5.09	No	Yes	0	4	7
56	R:R:S110	R:R:S161	13.7262	4.89	No	No	0	4	7
57	R:R:I111	R:R:S161	12.5047	7.74	Yes	No	0	6	7
58	R:R:L113	R:R:W238	27.0506	4.56	No	Yes	1	8	9
59	R:R:H279	R:R:W238	26.3166	8.46	Yes	Yes	1	9	9
60	R:R:D77	R:R:H279	20.9858	8.82	Yes	Yes	1	9	9
61	R:R:L97	R:R:W95	14.0102	11.39	Yes	Yes	1	8	9
62	R:R:C102	R:R:W95	23.9968	7.84	No	Yes	1	9	9
63	R:R:C102	R:R:V170	22.4216	3.42	No	No	0	9	5
64	R:R:D99	R:R:V170	20.7608	5.84	No	No	0	2	5
65	R:R:D99	R:R:K103	19.0892	9.68	No	No	0	2	7
66	R:R:K103	R:R:K169	17.4069	4.31	No	No	0	7	4
67	R:R:W238	R:R:Y234	43.6378	3.86	Yes	Yes	0	9	9
68	R:R:I201	R:R:Y234	31.4117	7.25	No	Yes	0	8	9
69	R:R:I201	R:R:T124	30.1902	6.08	No	No	0	8	9
70	R:R:C204	R:R:T124	34.0209	3.38	No	No	0	8	9
71	R:R:T124	R:R:Y205	24.5808	4.99	No	Yes	0	9	9
72	R:R:R127	R:R:Y287	19.5446	4.12	No	Yes	0	9	9
73	R:R:R127	R:R:Y205	18.1623	7.2	No	Yes	0	9	9
74	R:R:I230	R:R:Y287	19.7911	3.63	No	Yes	0	8	9
75	R:R:I230	R:R:Y205	18.4034	6.04	No	Yes	0	8	9
76	R:R:C204	R:R:Y128	31.8136	9.41	No	Yes	0	8	8
77	R:R:V132	R:R:Y128	16.0139	7.57	No	Yes	0	8	8
78	R:R:S133	R:R:V132	11.6743	1.62	No	No	0	6	8
79	R:R:K169	R:R:S178	14.0102	6.12	No	No	0	4	5
80	R:R:E179	R:R:S178	12.2957	4.31	No	No	0	4	5
81	R:R:E179	R:R:W182	10.5706	10.9	No	No	0	4	3
82	R:R:F194	R:R:N242	15.746	6.04	Yes	Yes	0	8	8
83	R:R:I227	R:R:Y205	22.7485	7.25	No	Yes	0	7	9
84	R:R:I227	R:R:T223	13.0405	3.04	No	No	0	7	8
85	R:R:H297	R:R:T296	23.8146	1.37	Yes	No	0	4	4
86	R:R:T296	R:R:V292	21.4573	1.59	No	No	0	4	5
87	R:R:R295	R:R:V292	19.0892	2.62	No	No	0	8	5
88	R:R:R222	R:R:R295	16.7051	3.2	No	No	0	7	8
89	R:R:K225	R:R:R222	12.1511	6.19	No	No	0	6	7
90	L:L:S3	R:R:W87	50.9135	11.12	No	No	1	0	6
91	R:R:F277	R:R:F80	34.8192	8.57	Yes	Yes	1	7	7
92	R:R:L84	R:R:Y38	16.3729	10.55	No	Yes	0	7	7
93	R:R:H190	R:R:W238	28.9794	5.29	Yes	Yes	1	6	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V1	R:R:Y177	5.05	0	No	Yes	0	4	0	1
L:L:V1	R:R:S186	8.08	0	No	No	0	5	0	1
L:L:S3	R:R:W87	11.12	1	No	No	0	6	0	1
L:L:S3	R:R:N106	5.96	1	No	Yes	0	6	0	1
L:L:S3	R:R:F109	5.28	1	No	No	0	6	0	1
L:L:E4	R:R:D176	5.2	1	No	No	0	6	0	1
L:L:E4	R:R:Y177	6.73	1	No	Yes	0	4	0	1
L:L:E4	R:R:Y183	7.86	1	No	Yes	0	3	0	1
L:L:V5	R:R:Y91	6.31	0	No	Yes	0	5	0	1
L:L:S6	R:R:Y91	5.09	0	No	Yes	0	5	0	1
L:L:R9	R:R:P21	4.32	0	No	No	0	4	0	1
L:L:R9	R:R:E23	9.3	0	No	No	0	3	0	1
R:R:C22	R:R:C259	5.46	0	Yes	No	9	7	1	2
R:R:C22	R:R:K262	6.47	0	Yes	No	9	1	1	2
R:R:A26	R:R:N24	4.69	0	No	No	4	3	2	1
R:R:E266	R:R:N24	14.46	0	No	No	4	3	2	1
R:R:T34	R:R:Y91	11.24	0	No	Yes	5	5	2	1
R:R:F109	R:R:F80	8.57	1	No	Yes	6	7	1	2
R:R:F277	R:R:F80	8.57	1	Yes	Yes	7	7	2	2
R:R:W87	R:R:W95	7.5	1	No	Yes	6	9	1	2
R:R:N106	R:R:W87	3.39	1	Yes	No	6	6	1	1
R:R:R273	R:R:Y91	4.12	0	Yes	Yes	6	5	1	1
R:R:D164	R:R:N106	9.42	1	No	Yes	4	6	2	1
R:R:H168	R:R:N106	11.48	1	No	Yes	5	6	2	1
R:R:F109	R:R:F277	6.43	1	No	Yes	6	7	1	2
R:R:D164	R:R:H168	7.56	1	No	No	4	5	2	2
R:R:D164	R:R:Y177	10.34	1	No	Yes	4	4	2	1
R:R:H168	R:R:Y177	9.8	1	No	Yes	5	4	2	1
R:R:Y177	R:R:Y183	6.95	1	Yes	Yes	4	3	1	1
R:R:L180	R:R:Y183	3.52	1	No	Yes	1	3	2	1
R:R:L180	R:R:R252	3.64	1	No	No	1	3	2	2
R:R:V187	R:R:Y183	5.05	0	No	Yes	4	3	2	1
R:R:Q248	R:R:Y183	7.89	0	No	Yes	5	3	2	1
R:R:T249	R:R:Y183	3.75	1	No	Yes	4	3	2	1
R:R:R252	R:R:Y183	21.61	1	No	Yes	3	3	2	1
R:R:L269	R:R:R273	4.86	0	No	Yes	4	6	2	1
R:R:F277	R:R:R273	5.34	1	Yes	Yes	7	6	2	1
R:R:C22	R:R:Q263	3.05	0	Yes	No	9	4	1	2
L:L:S6	R:R:N24	2.98	0	No	No	0	3	0	1
R:R:D176	R:R:S173	2.94	0	No	No	6	5	1	1
L:L:C11	R:R:P21	1.88	0	No	No	0	4	0	1
L:L:T10	R:R:C22	1.69	0	No	Yes	0	9	0	1
L:L:G2	R:R:R273	1.5	0	No	Yes	0	6	0	1
L:L:D7	R:R:S173	1.47	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9AST_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.38
Number of Linked Nodes	265
Number of Links	290
Number of Hubs	36
Number of Links mediated by Hubs	141
Number of Communities	6
Number of Nodes involved in Communities	48
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	50279
Length Of Smallest Path	3
Average Path Length	13.3478
Length of Longest Path	32
Minimum Path Strength	1.22
Average Path Strength	5.86
Maximum Path Strength	20.985
Minimum Path Correlation	0.7
Average Path Correlation	0.923616
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	45.6075
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.6415
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • signaling receptor binding • cytokine receptor binding • G protein-coupled receptor binding • chemokine receptor binding • CCR chemokine receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • receptor ligand activity • identical protein binding • protein homodimerization activity • protein dimerization activity • regulation of transforming growth factor beta production • multicellular organismal process • regulation of cellular process • positive regulation of biological process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • transforming growth factor beta production • positive regulation of cellular process • regulation of biosynthetic process • regulation of biological process • biological regulation • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • macromolecule metabolic process • positive regulation of transforming growth factor beta production • positive regulation of cytokine production • regulation of metabolic process • cellular response to stimulus • positive regulation of locomotion • regulation of cell motility • response to stimulus • regulation of B cell chemotaxis • positive regulation of chemotaxis • positive regulation of cell migration • regulation of lymphocyte chemotaxis • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • positive regulation of lymphocyte migration • regulation of leukocyte migration • lymphocyte migration • response to external stimulus • positive regulation of leukocyte chemotaxis • leukocyte migration • regulation of response to stimulus • response to chemical • regulation of locomotion • B cell chemotaxis • regulation of response to external stimulus • lymphocyte chemotaxis • regulation of lymphocyte migration • positive regulation of lymphocyte chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of mononuclear cell migration • cell motility • positive regulation of B cell chemotaxis • locomotion • cell chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • cellular response to chemical stimulus • immune system process • mononuclear cell migration • leukocyte chemotaxis • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • regulation of immune effector process • lymphocyte mediated immunity • T cell mediated immunity • positive regulation of leukocyte mediated immunity • T cell cytokine production • positive regulation of immune response • T-helper 1 cell cytokine production • leukocyte mediated immunity • positive regulation of adaptive immune response • positive regulation of T cell cytokine production • regulation of T cell mediated immunity • regulation of cytokine production involved in immune response • immune response • regulation of adaptive immune response • T-helper 1 type immune response • regulation of T-helper 1 type immune response • immune effector process • regulation of leukocyte mediated immunity • positive regulation of production of molecular mediator of immune response • regulation of immune response • regulation of production of molecular mediator of immune response • positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • positive regulation of lymphocyte mediated immunity • positive regulation of T-helper 1 cell cytokine production • regulation of T-helper 1 cell cytokine production • regulation of T cell cytokine production • CD4-positive, alpha-beta T cell cytokine production • regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • positive regulation of immune effector process • cytokine production involved in immune response • production of molecular mediator of immune response • positive regulation of T-helper 1 type immune response • adaptive immune response • regulation of lymphocyte mediated immunity • positive regulation of T cell mediated immunity • positive regulation of cytokine production involved in immune response • positive regulation of cell population proliferation • CD8-positive, alpha-beta T cell activation • regulation of alpha-beta T cell activation • regulation of leukocyte activation • CD8-positive, alpha-beta T cell proliferation • positive regulation of alpha-beta T cell proliferation • regulation of cell activation • positive regulation of CD8-positive, alpha-beta T cell activation • positive regulation of cell activation • T cell activation • alpha-beta T cell proliferation • lymphocyte proliferation • positive regulation of leukocyte activation • positive regulation of CD8-positive, alpha-beta T cell proliferation • alpha-beta T cell activation • regulation of leukocyte proliferation • positive regulation of T cell activation • cell population proliferation • regulation of CD8-positive, alpha-beta T cell proliferation • positive regulation of lymphocyte proliferation • positive regulation of T cell proliferation • positive regulation of alpha-beta T cell activation • mononuclear cell proliferation • regulation of cell population proliferation • regulation of leukocyte cell-cell adhesion • positive regulation of leukocyte proliferation • positive regulation of leukocyte cell-cell adhesion • lymphocyte activation • leukocyte cell-cell adhesion • leukocyte proliferation • leukocyte activation • positive regulation of cell-cell adhesion • positive regulation of lymphocyte activation • regulation of alpha-beta T cell proliferation • cell adhesion • cell-cell adhesion • positive regulation of mononuclear cell proliferation • regulation of cell-cell adhesion • T cell proliferation • regulation of lymphocyte proliferation • positive regulation of cell adhesion • regulation of cell adhesion • cell activation • regulation of T cell activation • regulation of T cell proliferation • regulation of mononuclear cell proliferation • regulation of CD8-positive, alpha-beta T cell activation • regulation of lymphocyte activation • negative regulation of biological process • negative regulation of interleukin-2 production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of interleukin-2 production • negative regulation of metabolic process • interleukin-2 production • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • natural killer cell chemotaxis • positive regulation of natural killer cell chemotaxis • regulation of natural killer cell chemotaxis • response to interleukin-4 • response to peptide • response to cytokine • cellular response to cytokine stimulus • cellular response to interleukin-4 • neutrophil chemotaxis • neutrophil migration • granulocyte migration • granulocyte chemotaxis • myeloid leukocyte migration • signaling • cell-cell signaling • cell communication • positive regulation of granzyme B production • granzyme B production • regulation of granzyme B production • negative regulation of lymphocyte activation • negative regulation of cell adhesion • regulation of T-helper 1 cell activation • CD4-positive, alpha-beta T cell activation • T-helper 1 cell activation • negative regulation of cell activation • regulation of CD4-positive, alpha-beta T cell activation • negative regulation of CD4-positive, alpha-beta T cell activation • negative regulation of T cell activation • negative regulation of immune system process • negative regulation of leukocyte cell-cell adhesion • negative regulation of cell-cell adhesion • negative regulation of alpha-beta T cell activation • negative regulation of T-helper 1 cell activation • negative regulation of leukocyte activation • positive regulation of CD4-positive, alpha-beta T cell proliferation • regulation of CD4-positive, alpha-beta T cell proliferation • positive regulation of CD4-positive, alpha-beta T cell activation • CD4-positive, alpha-beta T cell proliferation • interleukin-10 production • regulation of interleukin-10 production • positive regulation of interleukin-10 production • regulation of type II interferon production • type II interferon production • negative regulation of type II interferon production • regulation of granzyme A production • granzyme A production • positive regulation of granzyme A production • positive regulation of leukocyte mediated cytotoxicity • T cell mediated cytotoxicity • positive regulation of T cell mediated cytotoxicity • regulation of leukocyte mediated cytotoxicity • leukocyte mediated cytotoxicity • regulation of T cell mediated cytotoxicity • regulation of cell killing • positive regulation of cell killing • cell killing • RNA metabolic process • regulation of primary metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • negative regulation of DNA-templated transcription • primary metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • T-helper 2 cell cytokine production • type 2 immune response • regulation of T-helper 2 cell cytokine production • regulation of type 2 immune response • positive regulation of T-helper 2 cell cytokine production • positive regulation of type 2 immune response • negative regulation of DNA-binding transcription factor activity • negative regulation of molecular function • regulation of molecular function • regulation of DNA-binding transcription factor activity • cellular response to endogenous stimulus • cellular response to growth factor stimulus • response to transforming growth factor beta • cellular response to transforming growth factor beta stimulus • response to endogenous stimulus • response to growth factor • positive regulation of thymocyte migration • thymocyte migration • regulation of thymocyte migration • positive regulation of T cell migration • regulation of T cell migration • T cell migration • cell surface receptor signaling pathway • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • negative regulation of T-helper 1 type immune response • negative regulation of response to stimulus • negative regulation of immune response • negative regulation of adaptive immune response • negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • positive regulation of neutrophil chemotaxis • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of granulocyte chemotaxis • positive regulation of neutrophil migration • mature natural killer cell chemotaxis • regulation of immunoglobulin production in mucosal tissue • positive regulation of immunoglobulin mediated immune response • regulation of B cell mediated immunity • positive regulation of immunoglobulin production in mucosal tissue • B cell mediated immunity • mucosal immune response • organ or tissue specific immune response • immunoglobulin production • immunoglobulin production involved in immunoglobulin-mediated immune response • positive regulation of B cell mediated immunity • regulation of immunoglobulin mediated immune response • immunoglobulin production in mucosal tissue • positive regulation of immunoglobulin production • immunoglobulin mediated immune response • regulation of immunoglobulin production • regulation of defense response • defense response • regulation of inflammatory response • response to stress • regulation of response to stress • inflammatory response • humoral immune response • biological process involved in interspecies interaction between organisms • response to other organism • defense response to symbiont • antimicrobial humoral response • response to biotic stimulus • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to external biotic stimulus • regulation of localization • cellular localization • inorganic ion homeostasis • intracellular calcium ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • negative regulation of sequestering of calcium ion • calcium ion transport • metal ion transport • maintenance of location in cell • monoatomic cation transmembrane transport • localization • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • monoatomic ion transport • intracellular chemical homeostasis • monoatomic cation homeostasis • monoatomic cation transport • regulation of sequestering of calcium ion • intracellular monoatomic ion homeostasis • calcium ion transmembrane import into cytosol • sequestering of calcium ion • inorganic ion transmembrane transport • establishment of localization • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • cellular homeostasis • chemical homeostasis • calcium ion transmembrane transport • negative regulation of lymphocyte mediated immunity • negative regulation of cytokine production involved in immune response • negative regulation of immune effector process • negative regulation of production of molecular mediator of immune response • negative regulation of T cell mediated immunity • negative regulation of T cell cytokine production • negative regulation of leukocyte mediated immunity • response to virus • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • regulation of transmembrane transport • regulation of monoatomic ion transmembrane transport • regulation of calcium ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of transport • positive regulation of transport • regulation of monoatomic cation transmembrane transport • positive regulation of T cell chemotaxis • regulation of T cell chemotaxis • T cell chemotaxis • negative regulation of lymphocyte proliferation • negative regulation of T cell proliferation • negative regulation of leukocyte proliferation • negative regulation of mononuclear cell proliferation • negative regulation of cell population proliferation • negative regulation of alpha-beta T cell proliferation • negative regulation of CD4-positive, alpha-beta T cell proliferation • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • chemokine binding • cytokine binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell surface • external side of plasma membrane • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46094
Sequence	>9AST_nogp_Chain_R P C E N Q A W V F A T L A T T V L Y C L V F L L S L V G N S L V L W V L V K Y E S L E S L T N I F I L N L C L S D L V F A C L L P V W I S P Y H W G W V L G D F L C K L L N M I F S I S L Y S S I F F L T I M T I H R Y L S V V S P L S T L R V P T L R C R V L V T M A V W V A S I L S S I L D T I F H K V L S S G C D Y S E L T W Y L T S V Y Q H N L F F L L S L G I I L F C Y V E I L R T L F R S R S K R R H R T V K L I F A I V V A Y F L S W G P Y N F T L F L Q T L F R T Q I I R S C E A K Q Q L E Y A L L I C R N L A F S H C C F N P V L Y V F V G V K F R T H L K H V L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9AST	A	Protein	Chemokine	XCR1	Homo sapiens	Lymphotactin	-	Gi1/β1/γ2	3.07	2024-12-11	10.1073/pnas.2405732121
	9AST (No Gprot)	A	Protein	Chemokine	XCR1	Homo sapiens	Lymphotactin	-		3.07	2024-12-11	10.1073/pnas.2405732121
	8IC0	A	Protein	Chemokine	CXCR1	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.41	2023-07-19	10.1038/s41467-023-39799-2
	8IC0 (No Gprot)	A	Protein	Chemokine	CXCR1	Homo sapiens	Interleukin-8	-		3.41	2023-07-19	10.1038/s41467-023-39799-2

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