Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 4.9125136
2A:A:R42 6.19754129
3A:A:N50 6.89254166
4A:A:S51 4.008509
5A:A:F219 7.0554138
6A:A:H220 9.3085127
7A:A:M221 5.2125118
8A:A:F222 12.0254127
9A:A:Q227 4.2275469
10A:A:R228 6.245469
11A:A:E230 9.6475469
12A:A:R231 4.6625409
13A:A:K233 5.19769
14A:A:W234 6.36669
15A:A:F238 7.428509
16A:A:I244 3.95754178
17A:A:I245 3.96254117
18A:A:D249 9.974168
19A:A:D252 6.86754168
20A:A:Y253 10.312508
21A:A:R265 5.694169
22A:A:L270 4.94436
23A:A:F273 5.625639
24A:A:W277 9.612536
25A:A:N279 6.5025408
26A:A:W281 10.25465
27A:A:I285 3.64254177
28A:A:L289 4.57539
29A:A:F290 6.4656119
30A:A:L291 3.74438
31A:A:Q294 5.1275436
32A:A:F315 7.135406
33A:A:Y318 5.79536
34A:A:T320 2.7401
35A:A:P321 3.57667635
36A:A:E330 8.605433
37A:A:T335 5.505434
38A:A:K338 6.92535
39A:A:Y339 5.53667633
40A:A:I341 3.9675408
41A:A:R342 6.2775434
42A:A:F345 6.44538
43A:A:Y358 4.6425494
44A:A:C359 4.2525435
45A:A:Y360 6.425698
46A:A:F363 6.6575435
47A:A:N371 7.84754119
48A:A:R374 10.84254114
49A:A:I375 3.844119
50A:A:F376 4.903336138
51A:A:I383 3.425138
52A:A:R385 7.69714795
53A:A:H387 4.4725408
54A:A:Y391 9.165404
55B:B:L7 3.515408
56B:B:L30 5.125405
57B:B:V40 3.394503
58B:B:M45 4.155104
59B:B:L51 8.39419
60B:B:H54 6.59429719
61B:B:M61 3.915416
62B:B:W63 6.21714717
63B:B:S72 5.1575419
64B:B:D76 6.432519
65B:B:L79 5.3145227
66B:B:I81 3.4465197
67B:B:W82 10.546519
68B:B:Y85 14.3925414
69B:B:N88 6.285407
70B:B:K89 6.25714719
71B:B:H91 5.28754195
72B:B:I93 5.416507
73B:B:L95 5.1045228
74B:B:W99 10.7965129
75B:B:Y105 5.06167606
76B:B:N110 6.145474
77B:B:Y111 4.84667674
78B:B:C121 3.962578
79B:B:I123 4.098576
80B:B:Y124 5.825406
81B:B:H142 6.59579
82B:B:Y145 5.8475868
83B:B:L146 3.49477
84B:B:R150 6.62446
85B:B:F151 5.90167679
86B:B:L152 3.2275443
87B:B:I157 5.97477
88B:B:V158 3.9175445
89B:B:T159 6.0875479
90B:B:S161 4.5675409
91B:B:W169 9.71333678
92B:B:I171 4.0625476
93B:B:Q176 6.64574
94B:B:F180 7.616547
95B:B:H183 5.70286749
96B:B:D186 5.5569
97B:B:V187 3.872549
98B:B:M188 4.716568
99B:B:L190 4.9375445
100B:B:L192 4.2825445
101B:B:F199 5.87833649
102B:B:V200 6.9125456
103B:B:S201 4.2975449
104B:B:C204 5.122567
105B:B:K209 9.32546
106B:B:L210 6.24455
107B:B:W211 6.40571748
108B:B:Q220 4.65667657
109B:B:F222 6.398558
110B:B:H225 6.87833659
111B:B:D228 8.1469
112B:B:I232 6.42458
113B:B:F235 6.35625886
114B:B:F241 6.84333656
115B:B:T243 3.652558
116B:B:D247 9.93459
117B:B:T249 5.99456
118B:B:R251 11.385458
119B:B:F253 6.6125456
120B:B:R256 9.6925409
121B:B:D258 9.5925457
122B:B:Q259 4.1675406
123B:B:E260 5.25456
124B:B:Y264 5.55685
125B:B:H266 4.6825484
126B:B:F278 5.336587
127B:B:R283 5.8345219
128B:B:L284 5.1405
129B:B:L285 5.1975486
130B:B:Y289 7.48167687
131B:B:N295 9.9075486
132B:B:W297 8.135488
133B:B:K301 6.96754215
134B:B:R304 6.995485
135B:B:H311 7.76109
136B:B:R314 11.838568
137B:B:L318 4.7925406
138B:B:M325 4.156515
139B:B:V327 3.4254106
140B:B:W332 11.004509
141B:B:D333 8.264109
142B:B:L336 3.7025417
143B:B:K337 7.22754106
144B:B:W339 8.296109
145G:G:L15 2.125442
146G:G:Q18 3.9675449
147G:G:L19 4.072549
148G:G:M38 2.9725404
149G:G:D48 7.255409
150G:G:P49 3.1407
151G:G:L51 5.64406
152G:G:N59 5.68519
153G:G:P60 8.0975419
154G:G:F61 5.54625818
155R:R:F31 8.1275405
156R:R:F32 7.0725184
157R:R:S35 3.784186
158R:R:N42 7.2925429
159R:R:L55 7.05754149
160R:R:Y60 6.837147148
161R:R:F62 4.785158
162R:R:L66 4.11167629
163R:R:D70 6.788529
164R:R:Y76 9.16405
165R:R:K77 9.0185186
166R:R:L109 2.985405
167R:R:F110 12.785405
168R:R:L114 5.245425
169R:R:I118 6.7825427
170R:R:I132 6.4725409
171R:R:F133 9.285496
172R:R:Y138 6.492508
173R:R:W155 5.414159
174R:R:F168 7.28254254
175R:R:P173 3.1654253
176R:R:F182 6.26667606
177R:R:M185 5.62426
178R:R:F188 5.7475425
179R:R:Y193 5.72286729
180R:R:F197 3.5225426
181R:R:H203 8.145498
182R:R:L221 3.815427
183R:R:F228 5.81429
184R:R:W232 7.51714728
185R:R:F235 6.824246
186R:R:V239 3.5654245
187R:R:I265 4.6575427
188R:R:D272 5.3775429
189R:R:I275 4.625408
190R:R:Y276 9.0575429
191R:R:S280 6.14754148
192R:R:E282 7.12754146
193R:R:L283 3.081676148
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 40.79663.57NoNo085
2B:B:D66 B:B:L69 40.64835.43NoNo085
3R:R:T131 R:R:Y138 75.32798.74NoYes088
4R:R:D127 R:R:Y138 77.38775.75NoYes098
5R:R:D127 R:R:F62 77.40357.17NoYes098
6R:R:F62 R:R:T147 99.54512.59YesNo087
7R:R:M144 R:R:T147 99.4816.02NoNo027
8R:R:F61 R:R:M144 1009.95NoNo042
9R:R:F61 R:R:Q56 99.89813.51NoNo048
10R:R:K53 R:R:Q56 99.86362.71NoNo058
11B:B:F335 R:R:K53 64.27253.72NoNo045
12B:B:D333 B:B:F335 64.280913.14YesNo094
13B:B:D333 B:B:H311 63.868711.35YesYes1099
14B:B:H311 B:B:T329 63.01286.85YesNo098
15B:B:L318 B:B:T329 62.45752.95YesNo068
16B:B:L318 B:B:S277 61.87947.51YesNo065
17B:B:G319 B:B:S277 62.02643.71NoNo055
18B:B:G319 B:B:W63 61.93522.81NoYes057
19B:B:S84 B:B:W63 36.77744.94NoYes157
20B:B:S84 B:B:Y85 34.8993.82NoYes154
21B:B:R68 B:B:Y85 41.702530.87NoYes054
22A:A:Y391 R:R:T131 73.83596.24YesNo048
23A:A:Y391 R:R:I132 70.00734.84YesYes049
24R:R:F133 R:R:I132 69.77433.77YesYes069
25R:R:F133 R:R:L199 76.25637.31YesNo966
26R:R:H203 R:R:L199 75.98895.14YesNo986
27A:A:D381 R:R:H203 38.49810.08NoYes988
28A:A:D381 A:A:Y360 38.40869.2NoYes988
29A:A:D378 A:A:Y360 22.518210.34NoYes078
30A:A:D378 A:A:I288 10.39788.4NoNo079
31A:A:F290 A:A:I375 11.00523.77YesYes1199
32A:A:R385 R:R:H203 39.304612.41YesYes958
33A:A:R385 A:A:Y360 44.8226.17YesYes958
34A:A:D378 A:A:H362 11.84186.3NoNo079
35B:B:S316 B:B:W332 17.05514.94NoYes099
36B:B:C317 B:B:S316 17.22933.44NoNo079
37B:B:C317 B:B:M61 17.40714.86NoYes076
38B:B:M61 B:B:S72 10.17213.07YesYes169
39A:A:N264 A:A:R265 18.4394.82NoYes099
40A:A:N264 A:A:Y311 19.52142.33NoNo096
41A:A:Y253 A:A:Y311 20.60355.96YesNo086
42A:A:L297 A:A:Y253 30.33093.52NoYes088
43A:A:L297 A:A:Q294 23.52936.65NoYes086
44A:A:L291 A:A:Q294 27.42452.66YesYes386
45A:A:L289 A:A:L291 33.09314.15YesYes398
46A:A:F273 A:A:L289 11.30576.09YesYes399
47A:A:F273 A:A:W277 26.56068.02YesYes396
48A:A:H357 A:A:W277 64.08320.1NoYes076
49A:A:H357 A:A:S286 65.03142.79NoNo078
50A:A:S286 A:A:Y360 65.23673.82NoYes988
51A:A:E344 A:A:I341 11.36054.1NoYes058
52A:A:E344 A:A:F345 11.57618.16NoYes358
53A:A:F273 A:A:F345 12.89536.43YesYes398
54A:A:L289 A:A:V287 11.28292.98YesNo096
55A:A:V287 A:A:W277 11.53634.9NoYes066
56A:A:C359 A:A:L289 11.29034.76YesYes359
57A:A:C359 A:A:W277 25.48753.92YesYes356
58B:B:L69 B:B:Y105 34.51727.03NoYes056
59B:B:H62 B:B:Y105 31.61294.36NoYes066
60B:B:H62 B:B:R150 31.291714.67NoYes466
61B:B:C148 B:B:T102 11.94143.38NoNo068
62B:B:R314 B:B:W332 12.038118.99YesYes089
63A:A:D249 A:A:K293 10.850916.59YesNo089
64A:A:L346 A:A:R342 13.44773.64NoYes344
65A:A:C359 A:A:L346 13.97643.17YesNo354
66A:A:R342 A:A:Y339 11.84478.23YesYes343
67B:B:L192 B:B:R150 21.74464.86YesYes456
68B:B:F199 B:B:L192 20.81993.65YesYes495
69B:B:F199 B:B:W211 21.95448.02YesYes498
70B:B:K209 B:B:W211 20.04234.64YesYes468
71B:B:K209 G:G:Q18 19.5894.07YesYes469
72G:G:L19 G:G:Q18 15.47265.32YesYes499
73B:B:L14 G:G:L19 15.12414.15NoYes089
74B:B:L14 G:G:K20 15.08362.82NoNo086
75G:G:A23 G:G:K20 14.88323.21NoNo086
76B:B:I18 G:G:A23 14.68253.25NoNo078
77B:B:I18 B:B:R22 14.48166.26NoNo076
78B:B:D258 B:B:R22 13.270617.87YesNo076
79B:B:M325 G:G:P49 12.1673.35YesYes057
80G:G:D48 G:G:P49 14.47183.22YesYes097
81B:B:L300 B:B:R283 39.38912.43NoYes069
82B:B:L300 G:G:M38 10.17582.83NoYes064
83B:B:R283 G:G:L51 25.74387.29YesYes096
84B:B:L300 G:G:C41 28.74926.35NoNo067
85B:B:F235 G:G:C41 28.19212.79YesNo067
86B:B:I43 B:B:L284 13.38524.28NoYes035
87B:B:L284 G:G:L51 12.20774.15YesYes056
88B:B:V40 G:G:L51 11.97072.98YesYes036
89B:B:I43 B:B:V40 22.96744.61NoYes033
90B:B:D298 B:B:R283 10.271513.1NoYes2199
91B:B:D298 B:B:V40 10.91845.84NoYes093
92B:B:K337 B:B:W339 36.20916.96YesYes1069
93B:B:K337 B:B:T50 35.60469.01YesNo063
94B:B:R52 B:B:T50 35.580910.35NoNo073
95B:B:F235 B:B:F278 18.67788.57YesYes867
96B:B:F278 B:B:L285 15.86028.53YesYes876
97B:B:L285 B:B:W297 11.89783.42YesYes868
98R:R:F62 R:R:L151 24.37133.65YesNo1586
99R:R:L151 R:R:S65 12.10566.01NoNo1569
100R:R:S65 R:R:W155 11.93576.18NoYes1599
101R:R:S69 R:R:W155 23.4043.71NoYes089
102R:R:S117 R:R:S69 23.34244.89NoNo098
103R:R:S117 R:R:W232 23.29576.18NoYes098
104R:R:I154 R:R:L151 12.10562.85NoNo1566
105R:R:I154 R:R:W155 11.93574.7NoYes1569
106R:R:L114 R:R:W232 12.0049.11YesYes258
107R:R:F110 R:R:L114 10.64466.09YesYes055
108B:B:M61 B:B:W63 27.12933.49YesYes167
109B:B:I43 B:B:M45 36.36572.92NoYes034
110B:B:R52 R:R:K53 35.56267.43NoNo075
111B:B:M45 B:B:W339 36.65453.49YesYes1049
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9K3L
Class A
SubFamily Peptide
Type Melanocortin
SubType MC2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.01
Date 2025-08-06
D.O.I. doi.org/10.1016/j.str.2025.03.004
Net Summary
Imin 2.59
Number of Linked Nodes 816
Number of Links 1045
Number of Hubs 193
Number of Links mediated by Hubs 693
Number of Communities 27
Number of Nodes involved in Communities 290
Number of Links involved in Communities 425
Path Summary
Number Of Nodes in MetaPath 112
Number Of Links MetaPath 111
Number of Shortest Paths 1247725
Length Of Smallest Path 3
Average Path Length 31.39
Length of Longest Path 70
Minimum Path Strength 1.27
Average Path Strength 6.26607
Maximum Path Strength 23.78
Minimum Path Correlation 0.7
Average Path Correlation 0.978146
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.17391
Average % Of Corr. Nodes 40.8731
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.7839
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • peptide receptor activity   • G protein-coupled peptide receptor activity   • melanocortin receptor activity   • corticotropin receptor activity   • neuropeptide receptor activity   • metabolic process   • regulation of metabolic process   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • G-protein beta-subunit binding
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9K3L_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMTSGIFET 
KFQVDKVNF HMFDVGQRD ERRKWIQCF NDVTAIIFV VSSYNRLQE 
ALNFKSIWN NRWLRTISV ILFLNKQDL LAEKVLAGK SKIEDYFPE 
FARYTTPED ATPEPGEDP RVTRAKYFI RDEFLRIST ASGDGRHYC 
YPHFTCVDT ENRRFNDCR DIIQRMHLR QYELLLSAD AVRSMDNAD 
DDSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9K3L_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>9K3L_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ01718
Sequence
>9K3L_Chain_R
PEEIFFTIS IVGVLENLI VLLAVFKNK NLQAPMYFF ICSLAISDM 
LGSLYKILE NADDIIDSL FVLSLLGSI FSLSVIAAD RYITIFHAL 
RYHSIVTMR RTVVVLTVI WTFCTGTGI TMVIFSHHV PTVITFTSL 
FPLMLVFIL CLYVHMFLL ARSHTRKIA NMKGAITLT ILLGVFIFC 
WAPFVLHVL LMTFCPSNP YCACYMSLF QVNGMLIMC NAVIDPFIY 
AFRSPELRD A


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GY7APeptideMelanocortinMC2Homo sapiensCorticotropinCachim(NtGi1-Gs)/β1/γ2; MRAP13.32023-01-11doi.org/10.1038/s41422-022-00751-6
8GY7 (No Gprot) APeptideMelanocortinMC2Homo sapiensCorticotropinCa3.32023-01-11doi.org/10.1038/s41422-022-00751-6
9K3L (No Gprot) APeptideMelanocortinMC2Homo sapiens--3.012025-08-06doi.org/10.1016/j.str.2025.03.004




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