psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:Y14	E:E:Y17	10.92	No	No	0	0	0
2	E:E:E15	L:L:R17	11.63	No	No	0	0	0
3	E:E:L18	E:E:Y16	16.41	No	No	0	0	0
4	E:E:Y16	L:L:K15	5.97	No	No	0	0	0
5	E:E:Y16	L:L:R17	4.12	No	No	0	0	0
6	E:E:D19	E:E:Y17	11.49	No	No	0	0	0
7	E:E:D19	L:L:K16	9.68	No	Yes	0	0	0
8	E:E:Y20	L:L:Y2	3.97	No	Yes	0	0	0
9	E:E:Y20	L:L:K11	3.58	No	No	0	0	0
10	E:E:Y20	R:R:H170	7.62	No	No	0	0	5
11	E:E:L21	L:L:G14	5.13	No	No	0	0	0
12	E:E:D22	L:L:K16	5.53	No	Yes	0	0	0
13	E:E:L23	R:R:M255	4.24	No	No	0	0	1
14	E:E:L31	E:E:V26	4.47	No	Yes	4	0	0
15	E:E:V26	R:R:S19	4.85	Yes	No	0	0	3
16	E:E:V26	R:R:C21	3.42	Yes	Yes	4	0	4
17	E:E:V26	R:R:P249	3.53	Yes	No	4	0	2
18	E:E:V26	R:R:C253	5.12	Yes	No	4	0	3
19	E:E:D27	R:R:D20	6.65	No	No	0	0	3
20	E:E:E28	E:E:K29	9.45	No	No	0	0	0
21	E:E:E28	E:E:K35	4.05	No	Yes	0	0	0
22	E:E:E28	R:R:D20	24.69	No	No	0	0	3
23	E:E:L31	R:R:P249	6.57	No	No	4	0	2
24	E:E:L31	R:R:Y250	12.89	No	Yes	0	0	4
25	E:E:A33	R:R:Y250	4	No	Yes	0	0	4
26	E:E:H34	E:E:K35	7.86	No	Yes	0	0	0
27	E:E:H36	E:E:K35	6.55	No	Yes	0	0	0
28	E:E:K35	R:R:C21	4.85	Yes	Yes	0	0	4
29	E:E:I38	R:R:Y254	8.46	No	Yes	0	0	3
30	E:E:V39	R:R:Y254	6.31	No	Yes	0	0	3
31	E:E:V39	R:R:L257	4.47	No	No	0	0	5
32	E:E:F42	E:E:S45	3.96	No	No	0	0	0
33	E:E:F42	E:E:L46	9.74	No	Yes	0	0	0
34	E:E:F42	R:R:L237	12.18	No	No	0	0	6
35	E:E:L46	E:E:W43	3.42	Yes	Yes	1	0	0
36	E:E:W43	R:R:F230	7.02	Yes	Yes	1	0	4
37	E:E:W43	R:R:P234	5.4	Yes	No	0	0	9
38	E:E:W43	R:R:L264	3.42	Yes	No	0	0	7
39	E:E:L46	R:R:I229	4.28	Yes	Yes	1	0	6
40	E:E:L46	R:R:F230	4.87	Yes	Yes	1	0	4
41	E:E:L46	R:R:A233	4.73	Yes	No	0	0	5
42	E:E:F49	E:E:L53	8.53	No	No	0	0	0
43	E:E:V50	R:R:F230	5.24	No	Yes	0	0	4
44	E:E:F54	E:E:L58	12.18	Yes	No	0	0	0
45	E:E:F54	R:R:T222	7.78	Yes	No	0	0	6
46	E:E:L57	R:R:F197	10.96	No	Yes	1	0	6
47	E:E:L57	R:R:L221	4.15	No	No	1	0	7
48	E:E:L58	R:R:M215	8.48	No	No	0	0	5
49	E:E:S63	E:E:Y59	15.26	No	No	0	0	0
50	E:E:S61	R:R:F197	3.96	No	Yes	1	0	6
51	E:E:S61	R:R:A213	3.42	No	No	0	0	5
52	E:E:S61	R:R:N214	7.45	No	Yes	1	0	6
53	E:E:W62	R:R:A213	3.89	No	No	0	0	5
54	I:I:?1	R:R:E80	7.31	No	Yes	1	0	5
55	I:I:?1	R:R:D103	7.49	No	Yes	1	0	9
56	I:I:?1	R:R:D107	9.98	No	Yes	1	0	4
57	L:L:S1	L:L:Y2	13.99	No	Yes	0	0	0
58	L:L:V13	L:L:Y2	3.79	No	Yes	0	0	0
59	L:L:E5	L:L:S3	4.31	No	No	0	0	0
60	L:L:S3	R:R:R87	3.95	No	No	0	0	3
61	L:L:M4	R:R:E80	6.77	Yes	Yes	1	0	5
62	L:L:M4	R:R:L83	5.65	Yes	No	0	0	3
63	L:L:M4	R:R:R87	3.72	Yes	No	0	0	3
64	L:L:M4	R:R:D103	6.93	Yes	Yes	1	0	9
65	L:L:E5	L:L:K11	9.45	No	No	0	0	0
66	L:L:H6	R:R:E28	8.62	Yes	No	1	0	4
67	L:L:H6	R:R:F31	5.66	Yes	Yes	1	0	5
68	L:L:H6	R:R:N81	6.38	Yes	Yes	1	0	5
69	L:L:H6	R:R:I84	6.63	Yes	Yes	0	0	4
70	L:L:H6	R:R:Q259	4.95	Yes	Yes	1	0	4
71	L:L:F7	R:R:F31	5.36	Yes	Yes	1	0	5
72	L:L:F7	R:R:Y76	5.16	Yes	Yes	1	0	5
73	L:L:F7	R:R:K77	8.69	Yes	Yes	1	0	6
74	L:L:F7	R:R:F110	9.65	Yes	Yes	1	0	5
75	L:L:F7	R:R:F258	6.43	Yes	Yes	0	0	4
76	L:L:F7	R:R:G262	6.02	Yes	No	0	0	4
77	L:L:R8	L:L:W9	12	Yes	Yes	1	0	0
78	L:L:R8	R:R:D103	8.34	Yes	Yes	1	0	9
79	L:L:R8	R:R:D104	3.57	Yes	No	0	0	4
80	L:L:R8	R:R:D107	17.87	Yes	Yes	1	0	4
81	L:L:R8	R:R:V166	5.23	Yes	No	0	0	4
82	L:L:R8	R:R:S169	3.95	Yes	No	1	0	6
83	L:L:W9	R:R:V111	3.68	Yes	No	0	0	4
84	L:L:W9	R:R:S169	7.41	Yes	No	1	0	6
85	L:L:W9	R:R:F178	14.03	Yes	No	0	0	4
86	L:L:W9	R:R:V239	11.03	Yes	No	0	0	5
87	L:L:W9	R:R:M242	4.65	Yes	Yes	0	0	4
88	L:L:G10	R:R:F258	9.03	No	Yes	0	0	4
89	L:L:K11	R:R:R23	6.19	No	No	0	0	3
90	L:L:P12	R:R:M242	5.03	No	Yes	0	0	4
91	L:L:P12	R:R:P246	7.79	No	No	0	0	1
92	L:L:V13	R:R:H170	11.07	No	No	0	0	5
93	L:L:K16	L:L:R18	7.43	Yes	No	0	0	0
94	R:R:C21	R:R:C253	7.28	Yes	No	4	4	3
95	R:R:C21	R:R:S256	3.44	Yes	No	0	4	1
96	R:R:Q259	R:R:R23	3.5	Yes	No	0	4	3
97	R:R:F31	R:R:L26	4.87	Yes	Yes	1	5	4
98	R:R:L26	R:R:Q259	6.65	Yes	Yes	1	4	4
99	R:R:L26	R:R:M263	4.24	Yes	No	0	4	4
100	R:R:E29	R:R:P27	4.72	No	No	0	4	4
101	R:R:E28	R:R:N81	7.89	No	Yes	1	4	5
102	R:R:F31	R:R:I30	3.77	Yes	No	0	5	6
103	R:R:F31	R:R:K77	11.17	Yes	Yes	1	5	6
104	R:R:F31	R:R:N81	6.04	Yes	Yes	1	5	5
105	R:R:F31	R:R:Q259	4.68	Yes	Yes	1	5	4
106	R:R:F32	R:R:N81	10.87	No	Yes	0	4	5
107	R:R:K77	R:R:S35	6.12	Yes	Yes	0	6	6
108	R:R:I78	R:R:S35	6.19	No	Yes	0	5	6
109	R:R:G38	R:R:V37	3.68	No	No	0	7	4
110	R:R:V270	R:R:V37	4.81	No	No	0	6	4
111	R:R:E41	R:R:P273	12.58	No	No	0	7	9
112	R:R:E41	R:R:F274	17.49	No	No	6	7	6
113	R:R:E41	R:R:F278	4.66	No	Yes	6	7	6
114	R:R:A67	R:R:N42	4.69	No	No	0	9	9
115	R:R:D70	R:R:N42	10.77	Yes	No	0	9	9
116	R:R:N42	R:R:P273	4.89	No	No	0	9	9
117	R:R:F287	R:R:I44	6.28	No	No	0	7	7
118	R:R:P273	R:R:V45	3.53	No	No	0	9	9
119	R:R:F278	R:R:V45	3.93	Yes	No	0	6	9
120	R:R:I68	R:R:L46	5.71	No	No	0	6	8
121	R:R:F50	R:R:V49	11.8	No	No	0	3	8
122	R:R:N52	R:R:N54	5.45	Yes	No	3	6	6
123	R:R:L55	R:R:N52	5.49	Yes	Yes	3	9	6
124	R:R:A286	R:R:N52	6.25	No	Yes	0	8	6
125	R:R:K53	R:R:Q56	9.49	No	No	0	5	8
126	R:R:L55	R:R:N54	12.36	Yes	No	3	9	6
127	R:R:L55	R:R:Y60	8.21	Yes	Yes	3	9	8
128	R:R:E282	R:R:L55	5.3	No	Yes	3	6	9
129	R:R:F61	R:R:Q56	8.2	Yes	No	0	4	8
130	R:R:P58	R:R:Y138	4.17	Yes	Yes	2	6	8
131	R:R:P58	R:R:V142	3.53	Yes	Yes	2	6	7
132	R:R:P58	R:R:T147	6.99	Yes	No	2	6	7
133	R:R:M59	R:R:Y60	7.18	No	Yes	0	8	8
134	R:R:D127	R:R:M59	5.54	Yes	No	0	9	8
135	R:R:S280	R:R:Y60	7.63	No	Yes	3	8	8
136	R:R:E282	R:R:Y60	6.73	No	Yes	3	6	8
137	R:R:L283	R:R:Y60	4.69	No	Yes	3	8	8
138	R:R:F61	R:R:M144	7.46	Yes	No	2	4	2
139	R:R:F61	R:R:T147	3.89	Yes	No	2	4	7
140	R:R:F62	R:R:V123	7.87	Yes	No	0	8	6
141	R:R:D127	R:R:F62	7.17	Yes	Yes	0	9	8
142	R:R:F62	R:R:L151	4.87	Yes	No	0	8	6
143	R:R:S120	R:R:S65	4.89	No	No	0	7	9
144	R:R:S65	R:R:W155	6.18	No	Yes	0	9	9
145	R:R:D70	R:R:L66	5.43	Yes	Yes	1	9	9
146	R:R:L66	R:R:S120	6.01	Yes	No	0	9	7
147	R:R:L121	R:R:L66	5.54	No	Yes	1	8	9
148	R:R:I124	R:R:L66	4.28	No	Yes	1	8	9
149	R:R:D272	R:R:L66	5.43	No	Yes	1	9	9
150	R:R:L66	R:R:Y276	3.52	Yes	Yes	1	9	9
151	R:R:I68	R:R:W155	4.7	No	Yes	0	6	9
152	R:R:D70	R:R:S69	5.89	Yes	No	0	9	8
153	R:R:S117	R:R:S69	4.89	No	No	0	9	8
154	R:R:A269	R:R:D70	4.63	No	Yes	0	9	9
155	R:R:D272	R:R:D70	11.98	No	Yes	1	9	9
156	R:R:G73	R:R:S113	3.71	No	No	0	7	7
157	R:R:K77	R:R:Y76	4.78	Yes	Yes	1	6	5
158	R:R:E80	R:R:Y76	10.1	Yes	Yes	1	5	5
159	R:R:I106	R:R:Y76	6.04	Yes	Yes	1	5	5
160	R:R:D107	R:R:Y76	8.05	Yes	Yes	1	4	5
161	R:R:F110	R:R:Y76	20.63	Yes	Yes	1	5	5
162	R:R:K77	R:R:M266	5.76	Yes	No	0	6	6
163	R:R:I106	R:R:L79	4.28	Yes	No	0	5	6
164	R:R:E80	R:R:I84	8.2	Yes	Yes	0	5	4
165	R:R:D103	R:R:E80	3.9	Yes	Yes	1	9	5
166	R:R:E80	R:R:I106	5.47	Yes	Yes	1	5	5
167	R:R:I84	R:R:N88	4.25	Yes	No	0	4	4
168	R:R:L86	R:R:L92	9.69	No	No	0	3	4
169	R:R:N88	R:R:R87	6.03	No	No	0	4	3
170	R:R:M89	R:R:Y91	16.76	No	No	0	3	4
171	R:R:F98	R:R:L92	8.53	No	No	0	4	4
172	R:R:E99	R:R:R95	3.49	No	No	0	5	3
173	R:R:E99	R:R:T100	8.47	No	No	0	5	3
174	R:R:D103	R:R:D107	10.65	Yes	Yes	1	9	4
175	R:R:F110	R:R:L114	12.18	Yes	Yes	1	5	5
176	R:R:F110	R:R:F235	4.29	Yes	Yes	0	5	6
177	R:R:G162	R:R:V111	3.68	No	No	0	6	4
178	R:R:L112	R:R:W155	3.42	No	Yes	0	5	9
179	R:R:L114	R:R:S113	4.5	Yes	No	0	5	7
180	R:R:L114	R:R:W232	4.56	Yes	Yes	1	5	8
181	R:R:I265	R:R:L114	7.14	No	Yes	1	7	5
182	R:R:L115	R:R:T161	4.42	No	No	0	5	5
183	R:R:L115	R:R:L181	4.15	No	No	0	5	4
184	R:R:C158	R:R:G116	3.92	No	No	0	7	7
185	R:R:F119	R:R:I118	5.02	No	Yes	0	5	7
186	R:R:I118	R:R:M185	4.37	Yes	Yes	0	7	6
187	R:R:F228	R:R:I118	5.02	Yes	Yes	1	9	7
188	R:R:I118	R:R:W232	11.74	Yes	Yes	1	7	8
189	R:R:F228	R:R:L121	3.65	Yes	No	1	9	8
190	R:R:L121	R:R:Y276	4.69	No	Yes	1	8	9
191	R:R:I124	R:R:R128	5.01	No	No	1	8	9
192	R:R:I124	R:R:Y276	9.67	No	Yes	1	8	9
193	R:R:A125	R:R:Y193	4	No	Yes	0	8	9
194	R:R:D127	R:R:T131	4.34	Yes	No	2	9	8
195	R:R:D127	R:R:Y138	10.34	Yes	Yes	2	9	8
196	R:R:D127	R:R:V142	4.38	Yes	Yes	2	9	7
197	R:R:R128	R:R:Y193	8.23	No	Yes	1	9	9
198	R:R:R128	R:R:Y276	7.2	No	Yes	1	9	9
199	R:R:F133	R:R:Y129	18.57	Yes	No	2	6	8
200	R:R:L192	R:R:Y129	7.03	No	No	0	7	8
201	R:R:H195	R:R:Y129	7.62	No	No	2	5	8
202	R:R:I130	R:R:I141	5.89	No	No	0	6	5
203	R:R:I130	R:R:V142	4.61	No	Yes	0	6	7
204	R:R:T131	R:R:Y138	9.99	No	Yes	2	8	8
205	R:R:F133	R:R:I132	5.02	Yes	No	2	6	9
206	R:R:I132	R:R:L199	4.28	No	No	2	9	6
207	R:R:F133	R:R:H195	14.71	Yes	No	2	6	5
208	R:R:F133	R:R:M196	3.73	Yes	No	0	6	9
209	R:R:F133	R:R:L199	12.18	Yes	No	2	6	6
210	R:R:H134	R:R:I141	5.3	No	No	0	5	5
211	R:R:I141	R:R:R137	3.76	No	No	0	5	5
212	R:R:H139	R:R:Y138	10.89	No	Yes	0	5	8
213	R:R:V142	R:R:Y138	11.36	Yes	Yes	2	7	8
214	R:R:R146	R:R:T143	6.47	No	No	0	7	8
215	R:R:M144	R:R:T147	4.52	No	No	2	2	7
216	R:R:F157	R:R:T161	10.38	No	No	0	3	5
217	R:R:G160	R:R:T159	3.64	No	No	0	2	3
218	R:R:M165	R:R:T161	4.52	No	No	0	4	5
219	R:R:M165	R:R:T177	4.52	No	No	0	4	4
220	R:R:F168	R:R:I167	7.54	No	No	0	4	5
221	R:R:H170	R:R:M242	5.25	No	Yes	0	5	4
222	R:R:P173	R:R:V172	5.3	No	No	0	3	3
223	R:R:F244	R:R:V172	3.93	No	No	0	4	3
224	R:R:V175	R:R:V239	4.81	No	No	0	4	5
225	R:R:T243	R:R:V175	14.28	No	No	0	4	4
226	R:R:F244	R:R:I176	5.02	No	No	0	4	3
227	R:R:F178	R:R:W232	4.01	No	Yes	0	4	8
228	R:R:L240	R:R:T179	10.32	No	No	0	5	4
229	R:R:F182	R:R:P183	4.33	Yes	No	0	6	4
230	R:R:F182	R:R:L186	4.87	Yes	Yes	1	6	6
231	R:R:F182	R:R:F228	7.5	Yes	Yes	1	6	9
232	R:R:F182	R:R:I229	3.77	Yes	Yes	1	6	6
233	R:R:F182	R:R:W232	7.02	Yes	Yes	1	6	8
234	R:R:F182	R:R:V236	6.55	Yes	No	0	6	5
235	R:R:L184	R:R:M185	7.07	No	Yes	0	4	6
236	R:R:F188	R:R:M185	3.73	No	Yes	0	5	6
237	R:R:F228	R:R:L186	6.09	Yes	Yes	1	9	6
238	R:R:I229	R:R:L186	5.71	Yes	Yes	1	6	6
239	R:R:F188	R:R:L192	9.74	No	No	0	5	7
240	R:R:I189	R:R:Y193	3.63	No	Yes	0	8	9
241	R:R:L190	R:R:L225	6.92	No	No	1	5	7
242	R:R:L221	R:R:Y193	7.03	No	Yes	1	7	9
243	R:R:L224	R:R:Y193	4.69	No	Yes	1	8	9
244	R:R:Y193	R:R:Y276	4.96	Yes	Yes	1	9	9
245	R:R:F197	R:R:N214	8.46	Yes	Yes	1	6	6
246	R:R:F197	R:R:L221	3.65	Yes	No	1	6	7
247	R:R:L198	R:R:R201	4.86	No	No	0	3	6
248	R:R:H203	R:R:L199	5.14	No	No	0	8	6
249	R:R:R201	R:R:R205	13.86	No	No	0	6	4
250	R:R:I207	R:R:S208	4.64	No	No	0	7	5
251	R:R:L210	R:R:R212	6.07	No	No	0	5	4
252	R:R:G217	R:R:N214	5.09	No	Yes	0	7	6
253	R:R:G217	R:R:T220	3.64	No	No	0	7	9
254	R:R:I275	R:R:L224	4.28	No	No	1	8	8
255	R:R:L224	R:R:Y276	9.38	No	Yes	1	8	9
256	R:R:I271	R:R:V227	7.68	No	No	0	7	6
257	R:R:I275	R:R:V227	4.61	No	No	0	8	6
258	R:R:F228	R:R:W232	5.01	Yes	Yes	1	9	8
259	R:R:F230	R:R:I229	3.77	Yes	Yes	1	4	6
260	R:R:C231	R:R:N268	7.87	No	No	0	8	9
261	R:R:I265	R:R:W232	4.7	No	Yes	1	7	8
262	R:R:N261	R:R:P234	8.15	No	No	0	5	9
263	R:R:F235	R:R:V239	3.93	Yes	No	0	6	5
264	R:R:F235	R:R:F258	5.36	Yes	Yes	0	6	4
265	R:R:F235	R:R:I265	10.05	Yes	No	0	6	7
266	R:R:L237	R:R:L241	6.92	No	No	5	6	4
267	R:R:L237	R:R:Y254	16.41	No	Yes	5	6	3
268	R:R:H238	R:R:M255	5.25	No	No	0	5	1
269	R:R:F258	R:R:H238	24.89	Yes	No	0	4	5
270	R:R:C245	R:R:L241	4.76	No	No	0	4	4
271	R:R:L241	R:R:Y254	4.69	No	Yes	5	4	3
272	R:R:M242	R:R:M255	4.33	Yes	No	0	4	1
273	R:R:F244	R:R:T243	3.89	No	No	0	4	4
274	R:R:C245	R:R:C251	5.46	No	No	0	4	4
275	R:R:N248	R:R:P249	6.52	No	No	0	4	2
276	R:R:N248	R:R:Y250	11.63	No	Yes	0	4	4
277	R:R:C251	R:R:N248	9.45	No	No	0	4	4
278	R:R:N261	R:R:Y254	5.81	No	Yes	0	5	3
279	R:R:M263	R:R:V260	4.56	No	No	0	4	3
280	R:R:D272	R:R:N268	14.81	No	No	0	9	9
281	R:R:F274	R:R:F278	4.29	No	Yes	6	6	6
282	R:R:I275	R:R:Y276	6.04	No	Yes	1	8	9
283	R:R:P281	R:R:S280	3.56	No	No	0	5	8
284	R:R:L283	R:R:S280	4.5	No	No	3	8	8
285	R:R:F287	R:R:M290	6.22	No	No	0	7	6
286	E:E:I24	E:E:P25	3.39	No	No	0	0	0
287	R:R:A277	R:R:V45	3.39	No	No	0	8	9
288	R:R:C267	R:R:I271	3.27	No	No	0	4	7
289	R:R:S35	R:R:S74	3.26	Yes	No	0	6	8
290	E:E:I24	R:R:A252	3.25	No	No	0	0	3
291	R:R:S108	R:R:V166	3.23	No	No	0	5	4
292	R:R:F50	R:R:F61	3.22	No	Yes	0	3	4
293	R:R:S97	R:R:T101	3.2	No	No	0	1	3
294	R:R:C64	R:R:L46	3.17	No	No	0	6	8
295	R:R:C158	R:R:L115	3.17	No	No	0	7	5
296	R:R:T152	R:R:V149	3.17	No	No	0	3	3
297	R:R:T179	R:R:V236	3.17	No	No	0	4	5
298	R:R:I163	R:R:S108	3.1	Yes	No	0	4	5
299	R:R:M185	R:R:S122	3.07	Yes	No	0	6	6
300	R:R:I154	R:R:V123	3.07	No	No	0	6	6
301	R:R:H171	R:R:P173	3.05	No	No	0	3	3
302	R:R:I132	R:R:T131	3.04	No	No	2	9	8
303	R:R:M165	R:R:T174	3.01	No	No	0	4	5
304	R:R:G96	R:R:R95	3	No	No	0	2	3
305	R:R:L210	R:R:S208	3	No	No	0	5	5
306	E:E:L18	L:L:V13	2.98	No	No	0	0	0
307	E:E:L55	E:E:V51	2.98	No	No	0	0	0
308	R:R:L26	R:R:V24	2.98	Yes	No	0	4	6
309	R:R:L198	R:R:V194	2.98	No	No	0	3	3
310	R:R:I84	R:R:I85	2.94	Yes	No	0	4	3
311	R:R:I105	R:R:I106	2.94	No	Yes	0	4	5
312	R:R:I163	R:R:I167	2.94	Yes	No	0	4	5
313	E:E:I56	E:E:M60	2.92	No	No	0	0	0
314	R:R:I34	R:R:M263	2.92	No	No	0	6	4
315	R:R:I36	R:R:L40	2.85	No	No	0	4	4
316	R:R:I68	R:R:L72	2.85	No	No	0	6	6
317	E:E:L57	E:E:M60	2.83	No	No	0	0	0
318	E:E:M60	R:R:L198	2.83	No	No	0	0	3
319	R:R:L43	R:R:M71	2.83	No	No	0	4	7
320	R:R:L46	R:R:M71	2.83	No	No	0	8	7
321	E:E:L21	L:L:K16	2.82	No	Yes	0	0	0
322	R:R:G116	R:R:W155	2.81	No	Yes	0	7	9
323	E:E:L53	R:R:L190	2.77	No	No	1	0	5
324	E:E:L53	R:R:L225	2.77	No	No	1	0	7
325	E:E:F54	R:R:A218	2.77	Yes	No	0	0	8
326	R:R:L186	R:R:L190	2.77	Yes	No	1	6	5
327	R:R:A218	R:R:F197	2.77	No	Yes	0	8	6
328	E:E:H34	E:E:I40	2.65	No	No	0	0	0
329	E:E:H36	E:E:I40	2.65	No	No	0	0	0
330	R:R:R137	R:R:S140	2.64	No	No	0	5	5
331	R:R:F62	R:R:V150	2.62	Yes	No	0	8	5
332	R:R:F278	R:R:I44	2.51	Yes	No	0	6	7
333	E:E:F54	E:E:L55	2.44	Yes	No	0	0	0
334	R:R:L109	R:R:Y76	2.34	No	Yes	0	5	5
335	R:R:L86	R:R:Y91	2.34	No	No	0	3	4
336	E:E:D19	L:L:Y2	2.3	No	Yes	0	0	0
337	E:E:Y17	R:R:R95	2.06	No	No	0	0	3
338	R:R:C21	R:R:P22	1.88	Yes	No	0	4	1
339	R:R:A57	R:R:P58	1.87	No	Yes	0	7	6
340	R:R:G38	R:R:S74	1.86	No	No	0	7	8
341	E:E:V50	R:R:G226	1.84	No	No	0	0	6
342	R:R:A286	R:R:A48	1.79	No	No	0	8	8
343	E:E:P25	R:R:S19	1.78	No	No	0	0	3
344	R:R:G217	R:R:K216	1.74	No	No	0	7	8
345	E:E:A33	E:E:S37	1.71	No	No	0	0	0
346	R:R:K93	R:R:P94	1.67	No	No	0	2	2
347	R:R:L26	R:R:P27	1.64	Yes	No	0	4	4
348	R:R:L210	R:R:P211	1.64	No	No	0	5	4
349	R:R:S74	R:R:V39	1.62	No	No	0	8	6
350	R:R:A277	R:R:I63	1.62	No	No	0	8	8
351	L:L:M4	R:R:A102	1.61	Yes	No	0	0	3
352	R:R:V149	R:R:V150	1.6	No	No	0	3	5
353	R:R:T152	R:R:V148	1.59	No	No	0	3	1
354	R:R:T152	R:R:V153	1.59	No	No	0	3	3
355	R:R:A126	R:R:L192	1.58	No	No	0	6	7
356	R:R:T100	R:R:T101	1.57	No	No	0	3	3
357	R:R:A200	R:R:N214	1.56	No	Yes	0	8	6
358	R:R:I36	R:R:S35	1.55	No	Yes	0	4	6
359	E:E:I40	E:E:V44	1.54	No	No	0	0	0
360	R:R:I223	R:R:V227	1.54	No	No	0	7	6
361	R:R:K206	R:R:S202	1.53	No	No	0	5	4
362	R:R:I30	R:R:T33	1.52	No	No	0	6	3
363	R:R:I34	R:R:T33	1.52	No	No	0	6	3
364	R:R:I163	R:R:T159	1.52	Yes	No	0	4	3
365	R:R:I163	R:R:T164	1.52	Yes	No	0	4	4
366	R:R:I219	R:R:T220	1.52	No	No	0	6	9
367	R:R:L184	R:R:S180	1.5	No	No	0	4	3
368	R:R:I78	R:R:I82	1.47	No	No	0	5	5
369	R:R:Q259	R:R:V25	1.43	Yes	No	0	4	5
370	R:R:I82	R:R:L86	1.43	No	No	0	5	3
371	R:R:L47	R:R:M290	1.41	No	No	0	4	6
372	R:R:K51	R:R:N52	1.4	No	Yes	0	5	6
373	R:R:L75	R:R:L79	1.38	No	No	0	4	6
374	R:R:L109	R:R:L75	1.38	No	No	0	5	4
375	R:R:H203	R:R:I207	1.33	No	No	0	8	7
376	E:E:S13	L:L:R18	1.32	No	No	0	0	0
377	R:R:R146	R:R:V149	1.31	No	No	0	7	3
378	R:R:R145	R:R:T143	1.29	No	No	0	4	8
379	E:E:S63	E:E:W62	1.24	No	No	0	0	0
380	E:E:K32	R:R:Y250	1.19	No	Yes	0	0	4
381	R:R:R279	R:R:R284	1.07	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:V26	4.278	5	4	0
2	E:E:K35	5.8275	4	0	0
3	E:E:W43	4.815	4	1	0
4	E:E:L46	5.408	5	1	0
5	E:E:F54	6.2925	4	0	0
6	L:L:Y2	6.0125	4	0	0
7	L:L:M4	4.936	5	1	0
8	L:L:H6	6.448	5	1	0
9	L:L:F7	6.885	6	1	0
10	L:L:R8	8.49333	6	1	0
11	L:L:W9	8.8	6	1	0
12	L:L:K16	6.365	4	0	0
13	R:R:C21	4.174	5	4	4
14	R:R:L26	4.076	5	1	4
15	R:R:F31	5.93571	7	1	5
16	R:R:S35	4.28	4	0	6
17	R:R:N52	4.6475	4	3	6
18	R:R:L55	7.84	4	3	9
19	R:R:P58	4.14	4	2	6
20	R:R:Y60	6.888	5	3	8
21	R:R:F61	5.6925	4	2	4
22	R:R:F62	5.6325	4	0	8
23	R:R:L66	5.035	6	1	9
24	R:R:D70	7.74	5	1	9
25	R:R:Y76	8.15714	7	1	5
26	R:R:K77	7.304	5	1	6
27	R:R:E80	6.95833	6	1	5
28	R:R:N81	7.795	4	1	5
29	R:R:I84	5.505	4	0	4
30	R:R:D103	7.462	5	1	9
31	R:R:I106	4.6825	4	1	5
32	R:R:D107	11.6375	4	1	4
33	R:R:F110	11.6875	4	1	5
34	R:R:L114	7.095	4	1	5
35	R:R:I118	6.5375	4	1	7
36	R:R:D127	6.354	5	2	9
37	R:R:F133	10.842	5	2	6
38	R:R:Y138	9.35	5	2	8
39	R:R:V142	5.97	4	2	7
40	R:R:W155	4.2775	4	0	9
41	R:R:I163	2.27	4	0	4
42	R:R:F182	5.67333	6	1	6
43	R:R:M185	4.56	4	0	6
44	R:R:L186	4.86	4	1	6
45	R:R:Y193	5.42333	6	1	9
46	R:R:F197	5.96	5	1	6
47	R:R:N214	5.64	4	1	6
48	R:R:F228	5.454	5	1	9
49	R:R:I229	4.3825	4	1	6
50	R:R:F230	5.225	4	1	4
51	R:R:W232	6.17333	6	1	8
52	R:R:F235	5.9075	4	0	6
53	R:R:M242	4.815	4	0	4
54	R:R:Y250	7.4275	4	0	4
55	R:R:Y254	8.336	5	5	3
56	R:R:F258	11.4275	4	0	4
57	R:R:Q259	4.242	5	1	4
58	R:R:Y276	6.49429	7	1	9
59	R:R:F278	3.8475	4	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V13	L:L:Y2	16.2234	3.79	No	Yes	0	0	0
2	E:E:D19	L:L:Y2	30.642	2.3	No	Yes	0	0	0
3	E:E:D19	E:E:Y17	16.8414	11.49	No	No	0	0	0
4	E:E:D19	L:L:K16	12.1437	9.68	No	Yes	0	0	0
5	E:E:Y20	L:L:Y2	19.9283	3.97	No	Yes	0	0	0
6	E:E:Y20	R:R:H170	18.8435	7.62	No	No	0	0	5
7	L:L:V13	R:R:H170	22.1243	11.07	No	No	0	0	5
8	R:R:H170	R:R:M242	40.0704	5.25	No	Yes	0	5	4
9	R:R:N248	R:R:P249	42.411	6.52	No	No	0	4	2
10	R:R:C251	R:R:N248	53.9235	9.45	No	No	0	4	4
11	R:R:C245	R:R:C251	55.7612	5.46	No	No	0	4	4
12	R:R:C245	R:R:L241	57.5923	4.76	No	No	0	4	4
13	R:R:L237	R:R:L241	58.6015	6.92	No	No	5	6	4
14	E:E:F42	R:R:L237	67.734	12.18	No	No	0	0	6
15	E:E:F42	E:E:L46	71.2778	9.74	No	Yes	0	0	0
16	E:E:L46	R:R:I229	81.6135	4.28	Yes	Yes	1	0	6
17	R:R:F182	R:R:I229	68.4835	3.77	Yes	Yes	1	6	6
18	R:R:F182	R:R:W232	47.7662	7.02	Yes	Yes	1	6	8
19	R:R:F178	R:R:W232	59.8376	4.01	No	Yes	0	4	8
20	L:L:W9	R:R:F178	59.2623	14.03	Yes	No	0	0	4
21	L:L:W9	R:R:M242	43.0093	4.65	Yes	Yes	0	0	4
22	E:E:V26	R:R:P249	38.591	3.53	Yes	No	4	0	2
23	E:E:V26	R:R:C21	27.4138	3.42	Yes	Yes	4	0	4
24	E:E:K35	R:R:C21	21.6411	4.85	Yes	Yes	0	0	4
25	R:R:F230	R:R:I229	12.6237	3.77	Yes	Yes	1	4	6
26	R:R:F228	R:R:L186	31.9011	6.09	Yes	Yes	1	9	6
27	R:R:F228	R:R:W232	51.4251	5.01	Yes	Yes	1	9	8
28	R:R:A218	R:R:F197	10.1318	2.77	No	Yes	0	8	6
29	R:R:F197	R:R:L221	26.0922	3.65	Yes	No	1	6	7
30	R:R:L221	R:R:Y193	36.6942	7.03	No	Yes	1	7	9
31	R:R:Y193	R:R:Y276	39.7022	4.96	Yes	Yes	1	9	9
32	R:R:L121	R:R:Y276	45.0442	4.69	No	Yes	1	8	9
33	R:R:F228	R:R:L121	100	3.65	Yes	No	1	9	8
34	L:L:R8	L:L:W9	20.3787	12	Yes	Yes	1	0	0
35	L:L:F7	R:R:F31	18.4063	5.36	Yes	Yes	1	0	5
36	R:R:K77	R:R:Y76	17.7784	4.78	Yes	Yes	1	6	5
37	L:L:F7	R:R:F110	30.1949	9.65	Yes	Yes	1	0	5
38	L:L:R8	R:R:V166	10.1483	5.23	Yes	No	0	0	4
39	R:R:K77	R:R:S35	30.1259	6.12	Yes	Yes	0	6	6
40	R:R:I78	R:R:S35	14.2411	6.19	No	Yes	0	5	6
41	R:R:S35	R:R:S74	10.2041	3.26	Yes	No	0	6	8
42	R:R:L121	R:R:L66	54.0254	5.54	No	Yes	1	8	9
43	R:R:D70	R:R:L66	30.2278	5.43	Yes	Yes	1	9	9
44	R:R:D70	R:R:N42	25.1455	10.77	Yes	No	0	9	9
45	R:R:N42	R:R:P273	22.4564	4.89	No	No	0	9	9
46	R:R:P273	R:R:V45	11.2627	3.53	No	No	0	9	9
47	R:R:F278	R:R:I44	11.3284	2.51	Yes	No	0	6	7
48	R:R:L66	R:R:S120	26.3421	6.01	Yes	No	0	9	7
49	R:R:S120	R:R:S65	25.0074	4.89	No	No	0	7	9
50	R:R:S65	R:R:W155	23.6661	6.18	No	Yes	0	9	9
51	R:R:I118	R:R:W232	52.0431	11.74	Yes	Yes	1	7	8
52	R:R:I118	R:R:M185	95.5028	4.37	Yes	Yes	0	7	6
53	R:R:F188	R:R:M185	90.6637	3.73	No	Yes	0	5	6
54	R:R:F188	R:R:L192	89.4375	9.74	No	No	0	5	7
55	R:R:L192	R:R:Y129	86.9654	7.03	No	No	0	7	8
56	R:R:F133	R:R:Y129	84.273	18.57	Yes	No	2	6	8
57	R:R:F133	R:R:I132	71.8071	5.02	Yes	No	2	6	9
58	R:R:I132	R:R:T131	71.6098	3.04	No	No	2	9	8
59	R:R:T131	R:R:Y138	24.991	9.99	No	Yes	2	8	8
60	R:R:P58	R:R:Y138	13.8795	4.17	Yes	Yes	2	6	8
61	R:R:P58	R:R:T147	11.6145	6.99	Yes	No	2	6	7
62	R:R:D127	R:R:T131	45.2908	4.34	Yes	No	2	9	8
63	R:R:D127	R:R:M59	18.7909	5.54	Yes	No	0	9	8
64	R:R:M59	R:R:Y60	17.3576	7.18	No	Yes	0	8	8
65	R:R:D127	R:R:V142	10.1253	4.38	Yes	Yes	2	9	7
66	R:R:D127	R:R:F62	19.0736	7.17	Yes	Yes	0	9	8
67	R:R:L114	R:R:W232	57.5331	4.56	Yes	Yes	1	5	8
68	R:R:I78	R:R:I82	12.2259	1.47	No	No	0	5	5
69	R:R:I82	R:R:L86	10.2041	1.43	No	No	0	5	3
70	E:E:Y17	R:R:R95	12.6664	2.06	No	No	0	0	3
71	R:R:G116	R:R:W155	12.8374	2.81	No	Yes	0	7	9
72	R:R:C158	R:R:G116	11.4369	3.92	No	No	0	7	7
73	R:R:C158	R:R:L115	10.0299	3.17	No	No	0	7	5
74	R:R:I130	R:R:V142	15.464	4.61	No	Yes	0	6	7
75	R:R:I130	R:R:I141	12.3837	5.89	No	No	0	6	5
76	R:R:F133	R:R:L199	10.0661	12.18	Yes	No	2	6	6
77	R:R:F62	R:R:V150	12.867	2.62	Yes	No	0	8	5
78	R:R:V149	R:R:V150	11.4106	1.6	No	No	0	3	5
79	R:R:V175	R:R:V239	14.8394	4.81	No	No	0	4	5
80	R:R:T243	R:R:V175	12.7387	14.28	No	No	0	4	4
81	R:R:F244	R:R:T243	10.6315	3.89	No	No	0	4	4
82	L:L:F7	R:R:K77	14.9742	8.69	Yes	Yes	1	0	6
83	R:R:F110	R:R:L114	56.0275	12.18	Yes	Yes	1	5	5
84	R:R:I229	R:R:L186	27.4467	5.71	Yes	Yes	1	6	6
85	R:R:F182	R:R:F228	29.1857	7.5	Yes	Yes	1	6	9
86	R:R:F110	R:R:Y76	27.6801	20.63	Yes	Yes	1	5	5
87	R:R:F228	R:R:I118	45.8365	5.02	Yes	Yes	1	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:E15	L:L:R17	11.63	0	No	No	0	0	1	0
E:E:L18	E:E:Y16	16.41	0	No	No	0	0	1	1
E:E:Y16	L:L:K15	5.97	0	No	No	0	0	1	0
E:E:Y16	L:L:R17	4.12	0	No	No	0	0	1	0
E:E:D19	E:E:Y17	11.49	0	No	No	0	0	1	2
E:E:D19	L:L:K16	9.68	0	No	Yes	0	0	1	0
E:E:Y20	L:L:Y2	3.97	0	No	Yes	0	0	1	0
E:E:Y20	L:L:K11	3.58	0	No	No	0	0	1	0
E:E:Y20	R:R:H170	7.62	0	No	No	0	5	1	1
E:E:L21	L:L:G14	5.13	0	No	No	0	0	1	0
E:E:D22	L:L:K16	5.53	0	No	Yes	0	0	1	0
I:I:?1	R:R:E80	7.31	1	No	Yes	0	5	2	1
I:I:?1	R:R:D103	7.49	1	No	Yes	0	9	2	1
I:I:?1	R:R:D107	9.98	1	No	Yes	0	4	2	1
L:L:S3	R:R:R87	3.95	0	No	No	0	3	0	1
L:L:M4	R:R:E80	6.77	1	Yes	Yes	0	5	0	1
L:L:M4	R:R:L83	5.65	1	Yes	No	0	3	0	1
L:L:M4	R:R:R87	3.72	1	Yes	No	0	3	0	1
L:L:M4	R:R:D103	6.93	1	Yes	Yes	0	9	0	1
L:L:H6	R:R:E28	8.62	1	Yes	No	0	4	0	1
L:L:H6	R:R:F31	5.66	1	Yes	Yes	0	5	0	1
L:L:H6	R:R:N81	6.38	1	Yes	Yes	0	5	0	1
L:L:H6	R:R:I84	6.63	1	Yes	Yes	0	4	0	1
L:L:H6	R:R:Q259	4.95	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:F31	5.36	1	Yes	Yes	0	5	0	1
L:L:F7	R:R:Y76	5.16	1	Yes	Yes	0	5	0	1
L:L:F7	R:R:K77	8.69	1	Yes	Yes	0	6	0	1
L:L:F7	R:R:F110	9.65	1	Yes	Yes	0	5	0	1
L:L:F7	R:R:F258	6.43	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:G262	6.02	1	Yes	No	0	4	0	1
L:L:R8	R:R:D103	8.34	1	Yes	Yes	0	9	0	1
L:L:R8	R:R:D104	3.57	1	Yes	No	0	4	0	1
L:L:R8	R:R:D107	17.87	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:V166	5.23	1	Yes	No	0	4	0	1
L:L:R8	R:R:S169	3.95	1	Yes	No	0	6	0	1
L:L:W9	R:R:V111	3.68	1	Yes	No	0	4	0	1
L:L:W9	R:R:S169	7.41	1	Yes	No	0	6	0	1
L:L:W9	R:R:F178	14.03	1	Yes	No	0	4	0	1
L:L:W9	R:R:V239	11.03	1	Yes	No	0	5	0	1
L:L:W9	R:R:M242	4.65	1	Yes	Yes	0	4	0	1
L:L:G10	R:R:F258	9.03	0	No	Yes	0	4	0	1
L:L:K11	R:R:R23	6.19	0	No	No	0	3	0	1
L:L:P12	R:R:M242	5.03	0	No	Yes	0	4	0	1
L:L:P12	R:R:P246	7.79	0	No	No	0	1	0	1
L:L:V13	R:R:H170	11.07	0	No	No	0	5	0	1
R:R:Q259	R:R:R23	3.5	1	Yes	No	4	3	1	1
R:R:F31	R:R:L26	4.87	1	Yes	Yes	5	4	1	2
R:R:L26	R:R:Q259	6.65	1	Yes	Yes	4	4	2	1
R:R:E28	R:R:N81	7.89	1	No	Yes	4	5	1	1
R:R:F31	R:R:I30	3.77	1	Yes	No	5	6	1	2
R:R:F31	R:R:K77	11.17	1	Yes	Yes	5	6	1	1
R:R:F31	R:R:N81	6.04	1	Yes	Yes	5	5	1	1
R:R:F31	R:R:Q259	4.68	1	Yes	Yes	5	4	1	1
R:R:F32	R:R:N81	10.87	0	No	Yes	4	5	2	1
R:R:K77	R:R:S35	6.12	1	Yes	Yes	6	6	1	2
R:R:K77	R:R:Y76	4.78	1	Yes	Yes	6	5	1	1
R:R:E80	R:R:Y76	10.1	1	Yes	Yes	5	5	1	1
R:R:I106	R:R:Y76	6.04	1	Yes	Yes	5	5	2	1
R:R:D107	R:R:Y76	8.05	1	Yes	Yes	4	5	1	1
R:R:F110	R:R:Y76	20.63	1	Yes	Yes	5	5	1	1
R:R:K77	R:R:M266	5.76	1	Yes	No	6	6	1	2
R:R:E80	R:R:I84	8.2	1	Yes	Yes	5	4	1	1
R:R:D103	R:R:E80	3.9	1	Yes	Yes	9	5	1	1
R:R:E80	R:R:I106	5.47	1	Yes	Yes	5	5	1	2
R:R:I84	R:R:N88	4.25	0	Yes	No	4	4	1	2
R:R:N88	R:R:R87	6.03	0	No	No	4	3	2	1
R:R:D103	R:R:D107	10.65	1	Yes	Yes	9	4	1	1
R:R:F110	R:R:L114	12.18	1	Yes	Yes	5	5	1	2
R:R:F110	R:R:F235	4.29	1	Yes	Yes	5	6	1	2
R:R:G162	R:R:V111	3.68	0	No	No	6	4	2	1
R:R:L114	R:R:W232	4.56	1	Yes	Yes	5	8	2	2
R:R:H170	R:R:M242	5.25	0	No	Yes	5	4	1	1
R:R:V175	R:R:V239	4.81	0	No	No	4	5	2	1
R:R:F178	R:R:W232	4.01	0	No	Yes	4	8	1	2
R:R:F235	R:R:V239	3.93	0	Yes	No	6	5	2	1
R:R:F235	R:R:F258	5.36	0	Yes	Yes	6	4	2	1
R:R:H238	R:R:M255	5.25	0	No	No	5	1	2	2
R:R:F258	R:R:H238	24.89	0	Yes	No	4	5	1	2
R:R:M242	R:R:M255	4.33	0	Yes	No	4	1	1	2
R:R:S108	R:R:V166	3.23	0	No	No	5	4	2	1
E:E:L18	L:L:V13	2.98	0	No	No	0	0	1	0
R:R:I84	R:R:I85	2.94	0	Yes	No	4	3	1	2
E:E:L21	L:L:K16	2.82	0	No	Yes	0	0	1	0
R:R:L109	R:R:Y76	2.34	0	No	Yes	5	5	2	1
E:E:D19	L:L:Y2	2.3	0	No	Yes	0	0	1	0
L:L:M4	R:R:A102	1.61	1	Yes	No	0	3	0	1
R:R:Q259	R:R:V25	1.43	1	Yes	No	4	5	1	2
E:E:S13	L:L:R18	1.32	0	No	No	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GY7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	325
Number of Links	381
Number of Hubs	59
Number of Links mediated by Hubs	215
Number of Communities	6
Number of Nodes involved in Communities	79
Number of Links involved in Communities	117

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	84448
Length Of Smallest Path	3
Average Path Length	15.1156
Length of Longest Path	32
Minimum Path Strength	1.38
Average Path Strength	6.42035
Maximum Path Strength	17.07
Minimum Path Correlation	0.7
Average Path Correlation	0.930308
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.2742
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.8348
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • corticotropin receptor activity • neuropeptide receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • periplasmic space • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • type 5 melanocortin receptor binding • signaling receptor binding • melanocortin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • molecular function regulator activity • signaling receptor regulator activity • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • corticotropin hormone receptor binding • identical protein binding • regulation of localization • cellular localization • regulation of protein localization • negative regulation of biological process • negative regulation of protein localization to plasma membrane • localization • negative regulation of cellular process • intracellular protein localization • regulation of protein localization to membrane • negative regulation of protein localization • protein localization to cell periphery • protein localization to plasma membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • negative regulation of protein localization to membrane • regulation of cellular localization • macromolecule localization • negative regulation of protein localization to cell periphery • regulation of protein localization to plasma membrane • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • negative regulation of signaling • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of signaling • membrane-bounded organelle • intracellular organelle • organelle • intracellular membrane-bounded organelle • endoplasmic reticulum • endomembrane system • organelle subcompartment • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • organelle membrane • endoplasmic reticulum membrane • hormone activity • molecular function activator activity • receptor ligand activity • signaling receptor activator activity • multicellular organismal process • system process • corticosterone secretion • regulation of system process • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • regulation of biological quality • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • transport • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • regulation of multicellular organismal process • secretion • regulation of transport • lipid localization • export from cell • cell-cell signaling • endocrine process • regulation of lipid localization • hormone transport • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • extracellular region • extracellular space • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • GDP binding • G-protein beta/gamma-subunit complex binding • cation binding • metal ion binding • enzyme regulator activity • cyclase regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • ionotropic glutamate receptor binding • glutamate receptor binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • insulin-like growth factor receptor binding • cell division • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • positive regulation of autophagy • catabolic process • macroautophagy • autophagy • regulation of catabolic process • regulation of autophagy • positive regulation of catabolic process • positive regulation of metabolic process • regulation of macroautophagy • positive regulation of macroautophagy • process utilizing autophagic mechanism • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • nucleoside phosphate metabolic process • ribose phosphate metabolic process • purine nucleoside triphosphate metabolic process • GTP metabolic process • carbohydrate derivative metabolic process • primary metabolic process • nucleotide metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • phosphate-containing compound metabolic process • small molecule metabolic process • nucleoside triphosphate metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • developmental growth • growth • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • ciliary basal body • apical part of cell • plasma membrane region • apical plasma membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q01718
Sequence	>8GY7_nogp_Chain_R N S D C P R V V L P E E I F F T I S I V G V L E N L I V L L A V F K N K N L Q A P M Y F F I C S L A I S D M L G S L Y K I L E N I L I I L R N M G Y L K P R G S F E T T A D D I I D S L F V L S L L G S I F S L S V I A A D R Y I T I F H A L R Y H S I V T M R R T V V V L T V I W T F C T G T G I T M V I F S H H V P T V I T F T S L F P L M L V F I L C L Y V H M F L L A R S H T R K I S T L P R A N M K G A I T L T I L L G V F I F C W A P F V L H V L L M T F C P S N P Y C A C Y M S L F Q V N G M L I M C N A V I D P F I Y A F R S P E L R D A F K K M I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GY7	A	Peptide	Melanocortin	MC₂	Homo sapiens	Corticotropin	Ca	chim(NtGi1-Gs)/β1/γ2; MRAP1	3.3	2023-01-11	doi.org/10.1038/s41422-022-00751-6
	8GY7 (No Gprot)	A	Peptide	Melanocortin	MC₂	Homo sapiens	Corticotropin	Ca		3.3	2023-01-11	doi.org/10.1038/s41422-022-00751-6
	9K3L	A	Peptide	Melanocortin	MC₂	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.01	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3L (No Gprot)	A	Peptide	Melanocortin	MC₂	Homo sapiens	-	-		3.01	2025-08-06	doi.org/10.1016/j.str.2025.03.004

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Download 8GY7_nogp.zip

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